Preview
Sign-in for full Details 
Sign-in free and Explore the Exciting World of BiomedExperts:
- Over 1.500.000 Profiles
- More than 1.800 Organizations worldwide
- State of the Art Network Visualizations
- Manage your own Profile
- Locate Experts in your Country/Region
- Locate Experts in your 1. and 2. Level Network
- Connect to Experts Worldwide
NetworkView
Abdul Khokhar
This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers
together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles
free of charge to researchers worldwide.
Research Profile (preview)
Chemicals & Drugs
Disorders
Living Beings
Anatomy
Concepts & Ideas
Physiology
Phenomena
Sign-in to see full Profile
Network (preview)
41
Siddik, Zahid
26
Perez-Soler, Roman
5
Lopez-Berestein, Gabriel
5
Whitmire, Kenton
4
Newman, Robert
3
Shamsuddin, S
3
Maclean, DS
3
Huang, Zaifeng
3
Kuang, Jian
3
Ali, Mohammad
3
He, Guangan
3
Zhang, Yanping
2
Rosenblum, Michael
2
Hong, Waun Ki
2
Kobayashi, Ryuji
Sign-in to see all Coauthors
Publications
Sign-in to see all Publications
Sign in free and see...
Visualized networks:
See your personal network in
sophisticated graphical views
GeoTargeted Searches:
Locate experts around the world
and connect with global collaborators
Research Profiles:
See the visualized research activity
of experts around the globe
Sign-in to see more
Geonetwork of Abdul Khokhar (preview)
Cities where this author has publications
Cities where co-authors of this author have publications
Sign-in to see more
All Publications
-
2006: He G; Kuang J; Huang Z; Koomen J; Kobayashi R; Khokhar A R; Siddik Z H
Upregulation of p27 and its inhibition of CDK2/cyclin E activity following DNA damage by a novel platinum agent are dependent on the expression of p21.
British journal of cancer 2006;95(11):1514-24.
-
2005: Lu Charles; Perez-Soler Roman; Piperdi Bilal; Walsh Garrett L; Swisher Stephen G; Smythe W Roy; Shin Hyung J; Ro Jae Y; Feng Lei; Truong Mylene; Yalamanchili Adiseshu; Lopez-Berestein Gabriel; Hong Waun K; Khokhar Abdul R; Shin Dong M
Phase II study of a liposome-entrapped cisplatin analog (L-NDDP) administered intrapleurally and pathologic response rates in patients with malignant pleural mesothelioma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(15):3495-501.
-
2005: He Guangan; Siddik Zahid H; Huang Zaifeng; Wang Ruoning; Koomen John; Kobayashi Ryuji; Khokhar Abdul R; Kuang Jian
Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities.
Oncogene 2005;24(18):2929-43.
-
2005: Ali Mohammad S; Khan S Rounaq Ali; Ojima H; Guzman Ilse Y; Whitmire Kenton H; Siddik Zahid H; Khokhar Abdul R
Model platinum nucleobase and nucleoside complexes and antitumor activity: X-ray crystal structure of [PtIV(trans-1R,2R-diaminocyclohexane)trans-(acetate)2(9-ethylguanine)Cl]NO3.H2O.
Journal of inorganic biochemistry 2005;99(3):795-804.
-
2005: Mujoo Kalpana; Watanabe Masayuki; Khokhar Abdul R; Siddik Zahid H
Increased sensitivity of a metastatic model of prostate cancer to a novel tetravalent platinum analog.
The Prostate 2005;62(1):91-100.
-
2003: Mujoo Kalpana; Watanabe Masayuki; Nakamura Junichi; Khokhar Abdul R; Siddik Zahid H
Status of p53 phosphorylation and function in sensitive and resistant human cancer models exposed to platinum-based DNA damaging agents.
Journal of cancer research and clinical oncology 2003;129(12):709-18.
-
2003: Verschraegen C F; Kumagai S; Davidson R; Feig B; Mansfield P; Lee S J; Maclean D S; Hu W; Khokhar A R; Siddik Z H
Phase I clinical and pharmacological study of intraperitoneal cis-bis-neodecanoato( trans- R, R-1, 2-diaminocyclohexane)-platinum II entrapped in multilamellar liposome vesicles.
Journal of cancer research and clinical oncology 2003;129(10):549-55.
-
2003: Ali Mohammad S; Khokhar Abdul R
cis-1,4-diaminocyclohexane-Pt(II) and -(IV) adducts with DNA bases and nucleosides.
Journal of inorganic biochemistry 2003;96(4):452-6.
-
2003: Mukhopadhyay Uday; Thurston John; Whitmire Kenton H; Siddik Zahid H; Khokhar Abdul R
Preparation, characterization, and antitumor activity of new cisplatin analogues with 1-methyl-4-(methylamino)piperidine: crystal structure of [PtII(1-methyl-4-(methylamino) piperidine)(oxalate)].
Journal of inorganic biochemistry 2003;94(1-2):179-85.
-
2001: Kuang J; He G; Huang Z; Khokhar A R; Siddik Z H
Bimodal effects of 1R,2R-diaminocyclohexane(trans-diacetato)(dichloro)platinum(IV) on cell cycle checkpoints.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(11):3629-39.
-
2000: MacLean D S; Khokhar A R; Perez-Soler R
Neutron activation of NDDP, a liposomal platinum antitumor agent.
Cancer biotherapy & radiopharmaceuticals 2000;15(3):253-9.
-
2000: Maclean D S; Khokhar A R; Tyle P; Perez-Soler R
Intraliposomal chemical activation patterns of liposomal cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum (II) (L-NDDP)-a potential antitumour agent.
Journal of microencapsulation 2000;17(3):307-22.
-
2000: Ali Khan S R; Huang S; Shamsuddin S; Inutsuka S; Whitmire K H; Siddik Z H; Khokhar A R
Synthesis, characterization and cytotoxicity of new platinum(IV) axial carboxylate complexes: crystal structure of potential antitumor agent [PtIV(trans-1R,2R-diaminocyclohexane)trans(acetate)2Cl2].
Bioorganic & medicinal chemistry 2000;8(3):515-21.
-
1999: Ali M S; Whitmire K H; Toyomasu T; Siddik Z H; Khokhar A R
Preparation, characterization, and antitumor activity of new cisplatin analogs with homopiperazines: crystal structure of [PtII(1-methylhomopiperazine)(methylmalonato)].2H2O.
Journal of inorganic biochemistry 1999;77(3-4):231-8.
-
1999: Siddik Z H; Hagopian G S; Thai G; Tomisaki S; Toyomasu T; Khokhar A R
Role of p53 in the ability of 1,2-diaminocyclohexane-diacetato-dichloro-Pt(IV) to circumvent cisplatin resistance.
Journal of inorganic biochemistry 1999;77(1-2):65-70.
-
1999: Hagopian G S; Mills G B; Khokhar A R; Bast R C; Siddik Z H
Expression of p53 in cisplatin-resistant ovarian cancer cell lines: modulation with the novel platinum analogue (1R, 2R-diaminocyclohexane)(trans-diacetato)(dichloro)-platinum(IV).
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(3):655-63.
-
1999: Fox L E; Toshach K; Calderwood-Mays M; Khokhar A R; Kubilis P; Perez-Soler R; MacEwen E G
Evaluation of toxicosis of liposome-encapsulated cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum (II) in clinically normal cats.
American journal of veterinary research 1999;60(2):257-63.
-
1998: Yoshida M; Khokhar A R; Siddik Z H
Cytotoxicity and tolerance to DNA adducts of alicyclic mixed amine platinum(II) homologs in tumor models sensitive and resistant to cisplatin or tetraplatin.
Oncology reports 1998;5(5):1281-7.
-
1998: Shamsuddin S; Santillan C C; Stark J L; Whitmire K H; Siddik Z H; Khokhar A R
Synthesis, characterization, and antitumor activity of new platinum(IV) trans-carboxylate complexes: crystal structure of [Pt(cis-1,4-DACH)trans-(acetate)2Cl2]
Journal of inorganic biochemistry 1998;71(1-2):29-35.
-
1997: Perez-Soler R; Shin D M; Siddik Z H; Murphy W K; Huber M; Lee S J; Khokhar A R; Hong W K
Phase I clinical and pharmacological study of liposome-entrapped NDDP administered intrapleurally in patients with malignant pleural effusions.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(3):373-9.
-
1997: Khokhar A R; al-Baker S; Shamsuddin S; Siddik Z H
Chemical and biological studies on a series of novel (trans-(1R,2R)-, trans-(1S,2S)-, and cis-1,2-diaminocyclohexane)platinum(IV) carboxylate complexes.
Journal of medicinal chemistry 1997;40(1):112-6.
-
1996: Shamsuddin S; Takahashi I; Siddik Z H; Khokhar A R
Synthesis, characterization, and antitumor activity of a series of novel cisplatin analogs with cis-1,4-diaminocyclohexane as nonleaving amine group.
Journal of inorganic biochemistry 1996;61(4):291-301.
-
1996: Han I; Khokhar A R; Perez-Soler R
Intraliposomal conversion of lipophilic cis-bis-carboxylato-trans-R,R-1,2-diaminocyclohexane-platinum (II) complexes into cis-bis-dichloro-trans-R,R-1,2-diaminocyclohexane-platinum (II).
Cancer chemotherapy and pharmacology 1996;39(1-2):17-24.
-
1994: Siddik Z H; Thai G; Yoshida M; Zhang Y P; Khokhar A R
Tetravalent platinum complexes with ammine/amine carrier ligand configuration: circumvention of platinum resistance in vivo.
Anti-cancer drug design 1994;9(6):495-509.
-
1994: Yoshida M; Khokhar A R; Siddik Z H
Circumvention of platinum resistance: structure-activity relationship for homologous series of ammine/amine platinum(II) complexes in L1210 cell lines.
Anti-cancer drug design 1994;9(5):425-34.
-
1994: Yoshida M; Khokhar A R; Siddik Z H
Axial ligands and alicyclic ring size modulate the activity and biochemical pharmacology of ammine/cycloalkylamine-platinum(IV) complexes in tumor cells resistant to cis-diamminedichloroplatinum(II) or trans-1R,2R-1S,2S-diaminocyclohexanetetrachloroplatinum(IV).
Cancer research 1994;54(17):4691-7.
-
1994: Yoshida M; Khokhar A R; Kido Y; Ali-Osman F; Siddik Z H
Correlation of total and interstrand DNA adducts in tumor and kidney with antitumor efficacies and differential nephrotoxicities of cis-ammine/cyclohexylamine-dichloroplatinum(II) and cisplatin.
Biochemical pharmacology 1994;48(4):793-9.
-
1994: Yoshida M; Khokhar A R; Siddik Z H
Biochemical pharmacology of homologous alicyclic mixed amine platinum(II) complexes in sensitive and resistant tumor cell lines.
Cancer research 1994;54(13):3468-73.
-
1994: Kido Y; Khokhar A R; Siddik Z H
Glutathione-mediated modulation of tetraplatin activity against sensitive and resistant tumor cells.
Biochemical pharmacology 1994;47(9):1635-42.
-
1994: Siddik Z H; al-Baker S; Thai G; Khokhar A R
Modulatory effect of axial and equatorial ligands on antitumor activities of trans-1R,2R-diaminocyclohexane platinum(IV) complexes.
Anti-cancer drug design 1994;9(2):139-51.
-
1994: Khokhar A R; al-Baker S; Siddik Z H
Synthesis and antitumor activity of 1,2-diaminocyclohexane platinum(IV) complexes.
Journal of inorganic biochemistry 1994;54(1):39-47.
-
1994: Khokhar A R; Xu Q; Siddik Z H
Synthesis, characterization, and antitumor activity of amine platinum(II) and (IV) tellurate complexes.
Journal of inorganic biochemistry 1994;53(4):295-301.
-
1994: Han I; Ling Y H; Khokhar A R; Perez-Soler R
Cell death and DNA fragmentation induced by liposomal platinum(II) complex, L-NDDP in A2780 and A2780/PDD cells.
Anticancer research 1994;14(2A):421-6.
-
1994: Kido Y; Khokhar A R; Yoshida M; Thai G W; Siddik Z H
Pharmacokinetics of tetraplatin administered intraperitoneally with reduced glutathione in mice.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(2):312-7.
-
1994: Han I; Nguyen T; Yang L Y; Khokhar A R; Perez-Soler R
Cellular accumulation and DNA damage induced by liposomal cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum+ ++(II) in LoVo and LoVo/PDD cells.
Anti-cancer drugs 1994;5(1):64-8.
-
1994: Perez-Soler R; Francis K; al-Baker S; Pilkiewicz F; Khokhar A R
Preparation and characterization of liposomes containing a lipophilic cisplatin derivative for clinical use.
Journal of microencapsulation 1994;11(1):41-54.
-
1994: Perez-Soler R; Han I; al-Baker S; Khokhar A R
Lipophilic platinum complexes entrapped in liposomes: improved stability and preserved antitumor activity with complexes containing linear alkyl carboxylato leaving groups.
Cancer chemotherapy and pharmacology 1994;33(5):378-84.
-
1994: Siddik Z H; al-Baker S; Thai G; Khokhar A R
Antitumor activity of isomeric 1,2-diaminocyclohexane platinum(IV) complexes.
Journal of cancer research and clinical oncology 1994;120(7):409-14.
-
1994: Yoshida M; Khokhar A R; Zhang Y P; Thai G; Siddik Z H
Kinetics of tissue disposition of cis-ammine/cyclohexylamine-dichloroplatinum(II) and cisplatin in mice bearing FSaIIC tumors.
Cancer chemotherapy and pharmacology 1994;35(1):38-44.
-
1994: Siddik Z H; Thai G; Yoshida M; Zhang Y P; Khokhar A R
Ammine/amine platinum (II) complexes effective in vivo against murine tumors sensitive or resistant to cisplatin and tetraplatin.
Journal of cancer research and clinical oncology 1994;120(10):571-7.
-
1993: Han I; Ling Y H; al-Baker S; Khokhar A R; Perez-Soler R
Cellular pharmacology of liposomal cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum(II) in A2780/S and A2780/PDD cells.
Cancer research 1993;53(20):4913-9.
-
1993: Kido Y; Khokhar A R; al-Baker S; Siddik Z H
Modulation of cytotoxicity and cellular pharmacology of 1,2-diaminocyclohexane platinum (IV) complexes mediated by axial and equatorial ligands.
Cancer research 1993;53(19):4567-72.
-
1993: Khokhar A R; Xu Q; al-Baker S
X-ray crystal structure of tetrachloro(trans-d,l-1,2-diaminocyclohexane) platinum(IV) complex: a potential anticancer agent.
Journal of inorganic biochemistry 1993;52(1):51-8.
-
1993: Khokhar A R; Deng Y; al-Baker S; Yoshida M; Siddik Z H
Synthesis and antitumor activity of ammine/amine platinum(II) and (IV) complexes.
Journal of inorganic biochemistry 1993;51(3):677-87.
-
1993: Khokhar A R; Deng Y; Kido Y; Siddik Z H
Preparation, characterization, and antitumor activity of new ethylenediamine platinum(IV) complexes containing mixed carboxylate ligands.
Journal of inorganic biochemistry 1993;50(2):79-87.
-
1993: Kido Y; Khokhar A R; Siddik Z H
Differential cytotoxicity, uptake and DNA binding of tetraplatin and analogous isomers in sensitive and resistant cancer cell lines.
Anti-cancer drugs 1993;4(2):251-8.
-
1993: Siddik Z H; al-Baker S; Burditt T L; Khokhar A R
Differential antitumor activity and toxicity of isomeric 1,2-diaminocyclohexane platinum (II) complexes.
Journal of cancer research and clinical oncology 1993;120(1-2):12-6.
-
1992: Xu Q; Khokhar A R
Synthesis and characterization of N-methyliminodiacetato trans-R,R-, trans-S,S-, and cis-1,2-diaminocyclohexane platinum (IV) complexes: crystal structure of chloro(trans-R,R-1,2-diaminocyclohexane) (N-methyliminodiacetato) platinum(IV) chloride.
Journal of inorganic biochemistry 1992;48(3):217-26.
-
1992: Perez-Soler R; Khokhar A R
Lipophilic cisplatin analogues entrapped in liposomes: role of intraliposomal drug activation in biological activity.
Cancer research 1992;52(22):6341-7.
-
1992: Kido Y; Khokhar A R; Siddik Z H
Pharmacokinetics of intravenously injected [3H]tetrachloro(D,L-trans)1,2-diaminocyclohexane platinum (IV) (tetraplatin) in mice.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(5):673-8.
-
1992: al-Baker S; Perez-Soler R; Khokhar A R
Synthesis and biological studies of new lipid-soluble cisplatin analogues entrapped in liposomes.
Journal of inorganic biochemistry 1992;47(2):99-108.
-
1992: Khokhar A R; al-Baker S; Perez-Soler R
Toxicity and efficacy studies on a series of lipid-soluble dineodecanoato(trans-R,R- and trans-S,S-1,2-diaminocyclohexane) platinum (II) complexes entrapped in liposomes.
Anti-cancer drugs 1992;3(2):95-100.
-
1992: Khokhar A R; Xu Q; Newman R A; Kido Y; Siddik Z H
Synthesis, characterization, and antitumor activity of new chloroethylamine platinum complexes.
Journal of inorganic biochemistry 1992;45(3):211-9.
-
1992: Vadiei K; Siddik Z H; Khokhar A R; al-Baker S; Sampedro F; Perez-Soler R
Pharmacokinetics of liposome-entrapped cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum(II) and cisplatin given i.v. and i.p. in the rat.
Cancer chemotherapy and pharmacology 1992;30(5):365-9.
-
1991: Khokhar A R; Xu Q Y; Newman R A; Siddik Z H
Preparation, characterization, and antitumor activity of water-soluble aminoalkanol platinum(II) complexes.
Journal of inorganic biochemistry 1991;43(1):57-63.
-
1991: Khokhar A R; al-Baker S; Brown T; Perez-Soler R
Chemical and biological studies on a series of lipid-soluble (trans-(R,R)- and -(S,S)-1,2-diaminocyclohexane)platinum(II) complexes incorporated in liposomes.
Journal of medicinal chemistry 1991;34(1):325-9.
-
1990: Nishikawa K; Newman R A; Murray L; Khokhar A R; Rosenblum M G
Detection of cellular platinum using the monoclonal antibody 1C1.
Molecular biotherapy 1990;2(4):235-41.
-
1990: Perez-Soler R; Lopez-Berestein G; Lautersztain J; al-Baker S; Francis K; Macias-Kiger D; Raber M N; Khokhar A R
Phase I clinical and pharmacological study of liposome-entrapped cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum(II).
Cancer research 1990;50(14):4254-9.
-
1990: Khokhar A R; Xu Q Y; Siddik Z H
Synthesis, characterization, and antitumor activity of 1,2-bis(diphenylphosphino) ethane platinum(II) and palladium(II) complexes.
Journal of inorganic biochemistry 1990;39(2):117-23.
-
1990: Rosenblum M G; Murray J L; Stuckey S; Newman R A; Chaney S; Khokhar A R
Modification of methyliminodiacetato-trans-R,R-1,2-diamminocyclohexane platinum(II) pharmacology using a platinum-specific monoclonal antibody.
Cancer chemotherapy and pharmacology 1990;25(6):405-10.
-
1989: Perez-Soler R; Lautersztain J; Stephens L C; Wright K; Khokhar A R
Preclinical toxicity and pharmacology of liposome-entrapped cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum(II).
Cancer chemotherapy and pharmacology 1989;24(1):1-8.
-
1989: Khokhar A R; al-Baker S; Krakoff I H; Perez-Soler R
Toxicity and antitumor activity of cis-bis-carboxylato(trans-R,R-1,2-diaminocyclohexane) platinum(II) complexes entrapped in liposomes.
Cancer chemotherapy and pharmacology 1989;23(4):219-24.
-
1988: Khokhar A R; Al-Baker S; Perez-Soler R
Toxicity and anti-tumor activity of hydrophobic diammine and diaminocyclohexane platinum complexes entrapped in multilamellar vesicles.
Anti-cancer drug design 1988;3(3):177-84.
-
1988: Perez-Soler R; Yang L Y; Drewinko B; Lauterzstain J; Khokhar A R
Increased cytotoxicity and reversal of resistance to cis-diamminedichloro-platinum(II) with entrapment of cis-Bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum (II) in multilamellar lipid vesicles.
Cancer research 1988;48(16):4509-12.
-
1988: Khokhar A R; Lumetta G J; Bear J L
The synthesis and characterization of N-substituted iminodiacetato cis-, trans-R, R- and trans-S, S-1, 2-diaminocyclohexane platinum(II) complexes: steric effects on the diastereomeric ratios.
Journal of inorganic biochemistry 1988;33(4):247-55.
-
1988: Lautersztain J; Perez-Soler R; Turpin J; Khokhar A R; Siddik Z H; Schmidt K; Lopez-Berestein G
Cellular pharmacology of liposomal cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum (II) in mouse resident peritoneal macrophages, Kupffer cells, and hepatocytes.
Cancer research 1988;48(5):1300-6.
-
1988: Khokhar A R; Wright K; Siddik Z H; Perez-Soler R
Organ distribution and tumor uptake of liposome entrapped cis-bis-neodecanoato trans-R, R-1,2 diaminocyclohexane platinum (II) administered intravenously and into the proper hepatic artery.
Cancer chemotherapy and pharmacology 1988;22(3):223-7.
-
1987: Engineer M S; Ho D H; Khokhar A R; Newman R A; Bulger R E
A comparison of the effects of cisplatin and N-methyliminodiacetato-(1,2-diaminocyclohexane)-platinum(II) on renal function and gentamicin excretion in rats.
Toxicology 1987;47(3):307-15.
-
1987: Perez-Soler R; Khokhar A R; Lopez-Berestein G
Treatment and prophylaxis of experimental liver metastases of M5076 reticulosarcoma with cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum (II) encapsulated in multilamellar vesicles.
Cancer research 1987;47(24 Pt 1):6462-6.
-
1987: Perez-Soler R; Khokhar A R; Lautersztain J; Mitchell P A; Schmidt K L
Ultrastructural and freeze fracture localization of multilamellar liposomes containing a lipophilic cisplatin analogue in normal tissues and liver metastases of M5076 reticulosarcoma.
Cancer drug delivery 1987;4(2):75-88.
-
1986: Lautersztain J; Perez-Soler R; Khokhar A R; Newman R A; Lopez-Berestein G
Pharmacokinetics and tissue distribution of liposome-encapsulated cis-bis-N-decyl-iminodiacetato-1,2-diaminocyclohexane-platinum (II).
Cancer chemotherapy and pharmacology 1986;18(2):93-7.
Sign-in to see more