Chaitan Khosla

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Living Beings

Concepts & Ideas

Sign-in to see full Profile

Sign-in to see all Coauthors

Publications

TOP 3
Khosla Chaitan
Structures and mechanisms of polyketide synthases.
Bethune Michael T; Crespo-Bosque Mónica; Bergseng Elin; Mazumdar Kaushiki; Doyle Lara; Sestak Karol; Sollid Ludvig M; Khosla Chaitan
Noninflammatory gluten peptide analogs as biomarkers for celiac sprue.
Das Abhirup; Khosla Chaitan
Biosynthesis of aromatic polyketides in bacteria.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Chaitan Khosla (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Khosla Chaitan
Structures and mechanisms of polyketide synthases.
The Journal of organic chemistry 2009;74(17):6416-20.
2009: Bethune Michael T; Crespo-Bosque Mónica; Bergseng Elin; Mazumdar Kaushiki; Doyle Lara; Sestak Karol; Sollid Ludvig M; Khosla Chaitan
Noninflammatory gluten peptide analogs as biomarkers for celiac sprue.
Chemistry & biology 2009;16(8):868-81.
2009: Das Abhirup; Khosla Chaitan
Biosynthesis of aromatic polyketides in bacteria.
Accounts of chemical research 2009;42(5):631-9.
2009: Bethune Michael T; Siegel Matthew; Howles-Banerji Samuel; Khosla Chaitan
Interferon-gamma released by gluten-stimulated celiac disease-specific intestinal T cells enhances the transepithelial flux of gluten peptides.
The Journal of pharmacology and experimental therapeutics 2009;329(2):657-68.
2009: Khosla Chaitan; Kapur Shiven; Cane David E
Revisiting the modularity of modular polyketide synthases.
Current opinion in chemical biology 2009;13(2):135-43.
2009: Lord-Dufour Simon; Copland Ian B; Levros Louis-Charles; Post Martin; Das Abhirup; Khosla Chaitan; Galipeau Jacques; Rassart Eric; Annabi Borhane
Evidence for transcriptional regulation of the glucose-6-phosphate transporter by HIF-1alpha: Targeting G6PT with mumbaistatin analogs in hypoxic mesenchymal stromal cells.
Stem cells (Dayton, Ohio) 2009;27(3):489-97.
2009: Ehren Jennifer; Morón Belen; Martin Edith; Bethune Michael T; Gray Gary M; Khosla Chaitan
A food-grade enzyme preparation with modest gluten detoxification properties.
PloS one 2009;4(7):e6313.
2008: Ehren Jennifer; Govindarajan Sridhar; Morón Belén; Minshull Jeremy; Khosla Chaitan
Protein engineering of improved prolyl endopeptidases for celiac sprue therapy.
Protein engineering, design & selection : PEDS 2008;21(12):699-707.
2008: Lu Xuefeng; Vora Harmit; Khosla Chaitan
Overproduction of free fatty acids in E. coli: implications for biodiesel production.
Metabolic engineering 2008;10(6):333-9.
2008: Yuan Liya; Behdad Amir; Siegel Matthew; Khosla Chaitan; Higashikubo Ryuji; Rich Keith M
Tissue transgluaminase 2 expression in meningiomas.
Journal of neuro-oncology 2008;90(2):125-32.
2008: Castonguay Roselyne; Valenzano Chiara R; Chen Alice Y; Keatinge-Clay Adrian; Khosla Chaitan; Cane David E
Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase.
Journal of the American Chemical Society 2008;130(35):11598-9.
2008: Kapur Shiven; Khosla Chaitan
Biochemistry: Fit for an enzyme.
Nature 2008;454(7206):832-3.
2008: Kapur Shiven; Worthington Andrew; Tang Yinyan; Cane David E; Burkart Michael D; Khosla Chaitan
Mechanism based protein crosslinking of domains from the 6-deoxyerythronolide B synthase.
Bioorganic & medicinal chemistry letters 2008;18(10):3034-8.
2008: Ridley Christian P; Lee Ho Young; Khosla Chaitan
Evolution of polyketide synthases in bacteria.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(12):4595-600.
2008: Bethune Michael T; Khosla Chaitan
Parallels between pathogens and gluten peptides in celiac sprue.
PLoS pathogens 2008;4(2):e34.
2008: Morón Belén; Bethune Michael T; Comino Isabel; Manyani Hamid; Ferragud Marina; López Manuel Carlos; Cebolla Angel; Khosla Chaitan; Sousa Carolina
Toward the assessment of food toxicity for celiac patients: characterization of monoclonal antibodies to a main immunogenic gluten peptide.
PloS one 2008;3(5):e2294.
2008: Siegel Matthew; Strnad Pavel; Watts R Edward; Choi Kihang; Jabri Bana; Omary M Bishr; Khosla Chaitan
Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury.
PloS one 2008;3(3):e1861.
2008: Bethune Michael T; Ribka Erin; Khosla Chaitan; Sestak Karol
Transepithelial transport and enzymatic detoxification of gluten in gluten-sensitive rhesus macaques.
PloS one 2008;3(3):e1857.
2008: Bethune Michael T; Borda Juan T; Ribka Erin; Liu Michael-Xun; Phillippi-Falkenstein Kathrine; Jandacek Ronald J; Doxiadis Gaby G M; Gray Gary M; Khosla Chaitan; Sestak Karol
A non-human primate model for gluten sensitivity.
PloS one 2008;3(2):e1614.
2007: Pinkas Daniel M; Strop Pavel; Brunger Axel T; Khosla Chaitan
Transglutaminase 2 undergoes a large conformational change upon activation.
PLoS biology 2007;5(12):e327.
2007: Castonguay Roselyne; He Weiguo; Chen Alice Y; Khosla Chaitan; Cane David E
Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase.
Journal of the American Chemical Society 2007;129(44):13758-69.
2007: Alekseyev Viktor Y; Liu Corey W; Cane David E; Puglisi Joseph D; Khosla Chaitan
Solution structure and proposed domain domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase.
Protein science : a publication of the Protein Society 2007;16(10):2093-107.
2007: Xia Jiang; Bergseng Elin; Fleckenstein Burkhard; Siegel Matthew; Kim Chu-Young; Khosla Chaitan; Sollid Ludvig M
Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease.
Bioorganic & medicinal chemistry 2007;15(20):6565-73.
2007: Siegel Matthew; Xia Jiang; Khosla Chaitan
Structure-based design of alpha-amido aldehyde containing gluten peptide analogues as modulators of HLA-DQ2 and transglutaminase 2.
Bioorganic & medicinal chemistry 2007;15(18):6253-61.
2007: Vora Harmit; McIntire James; Kumar Pawan; Deshpande Milind; Khosla Chaitan
A scaleable manufacturing process for pro-EP-B2, a cysteine protease from barley indicated for celiac sprue.
Biotechnology and bioengineering 2007;98(1):177-85.
2007: Tang Yinyan; Chen Alice Y; Kim Chu-Young; Cane David E; Khosla Chaitan
Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase.
Chemistry & biology 2007;14(8):931-43.
2007: Gass Jonathan; Bethune Michael T; Siegel Matthew; Spencer Andrew; Khosla Chaitan
Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue.
Gastroenterology 2007;133(2):472-80.
2007: Siegel Matthew; Khosla Chaitan
Transglutaminase 2 inhibitors and their therapeutic role in disease states.
Pharmacology & therapeutics 2007;115(2):232-45.
2007: Lee Taek Soon; Das Abhirup; Khosla Chaitan
Structure-activity relationships of semisynthetic mumbaistatin analogs.
Bioorganic & medicinal chemistry 2007;15(15):5207-18.
2007: Chen Alice Y; Cane David E; Khosla Chaitan
Structure-based dissociation of a type I polyketide synthase module.
Chemistry & biology 2007;14(7):784-92.
2007: Gass Jonathan; Vora Harmit; Hofmann Alan F; Gray Gary M; Khosla Chaitan
Enhancement of dietary protein digestion by conjugated bile acids.
Gastroenterology 2007;133(1):16-23.
2007: Katz Leonard; Khosla Chaitan
Antibiotic production from the ground up.
Nature biotechnology 2007;25(4):428-9.
2007: Strnad Pavel; Harada Masaru; Siegel Matthew; Terkeltaub Robert A; Graham Robert M; Khosla Chaitan; Omary M Bishr
Transglutaminase 2 regulates mallory body inclusion formation and injury-associated liver enlargement.
Gastroenterology 2007;132(4):1515-26.
2007: Yuan L; Siegel M; Choi K; Khosla C; Miller C R; Jackson E N; Piwnica-Worms D; Rich K M
Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy.
Oncogene 2007;26(18):2563-73.
2007: Tse Martha Lovato; Watts R Edward; Khosla Chaitan
Substrate tolerance of module 6 of the epothilone synthetase.
Biochemistry 2007;46(11):3385-93.
2007: Lee Ho Young; Khosla Chaitan
Bioassay-guided evolution of glycosylated macrolide antibiotics in Escherichia coli.
PLoS biology 2007;5(2):e45.
2007: Ridley Christian P; Khosla Chaitan
Synthesis and biological activity of novel pyranopyrones derived from engineered aromatic polyketides.
ACS chemical biology 2007;2(2):104-8.
2007: Gass J; Khosla C
Prolyl endopeptidases.
Cellular and molecular life sciences : CMLS 2007;64(3):345-55.
2007: Khosla Chaitan; Tang Yinyan; Chen Alice Y; Schnarr Nathan A; Cane David E
Structure and mechanism of the 6-deoxyerythronolide B synthase.
Annual review of biochemistry 2007;76():195-221.
2006: Schnarr Nathan A; Khosla Chaitan
Trapping transient protein-protein interactions in polyketide biosynthesis.
ACS chemical biology 2006;1(11):679-80.
2006: Watts R Edward; Siegel Mathew; Khosla Chaitan
Structure-activity relationship analysis of the selective inhibition of transglutaminase 2 by dihydroisoxazoles.
Journal of medicinal chemistry 2006;49(25):7493-501.
2006: Tang Yinyan; Lee Ho Young; Tang Yi; Kim Chu-Young; Mathews Irimpan; Khosla Chaitan
Structural and functional studies on SCO1815: a beta-ketoacyl-acyl carrier protein reductase from Streptomyces coelicolor A3(2).
Biochemistry 2006;45(47):14085-93.
2006: Gass Jonathan; Vora Harmit; Bethune Michael T; Gray Gary M; Khosla Chaitan
Effect of barley endoprotease EP-B2 on gluten digestion in the intact rat.
The Journal of pharmacology and experimental therapeutics 2006;318(3):1178-86.
2006: Rude M A; Khosla C
Production of ansamycin polyketide precursors in Escherichia coli.
The Journal of antibiotics 2006;59(8):464-70.
2006: Tang Yinyan; Kim Chu-Young; Mathews Irimpan I; Cane David E; Khosla Chaitan
The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(30):11124-9.
2006: Siegel Matthew; Bethune Michael T; Gass Jonathan; Ehren Jennifer; Xia Jiang; Johannsen Alexandre; Stuge Tor B; Gray Gary M; Lee Peter P; Khosla Chaitan
Rational design of combination enzyme therapy for celiac sprue.
Chemistry & biology 2006;13(6):649-58.
2006: Bethune Michael T; Strop Pavel; Tang Yinyan; Sollid Ludvig M; Khosla Chaitan
Heterologous expression, purification, refolding, and structural-functional characterization of EP-B2, a self-activating barley cysteine endoprotease.
Chemistry & biology 2006;13(6):637-47.
2006: Hicks Leslie M; Mazur Matthew T; Miller Leah M; Dorrestein Pieter C; Schnarr Nathan A; Khosla Chaitan; Kelleher Neil L
Investigating nonribosomal peptide and polyketide biosynthesis by direct detection of intermediates on >70 kDa polypeptides by using Fourier-transform mass spectrometry.
Chembiochem : a European journal of chemical biology 2006;7(6):904-7.
2006: Strnad Pavel; Siegel Matthew; Toivola Diana M; Choi Kihang; Kosek Jon C; Khosla Chaitan; Omary M Bishr
Pharmacologic transglutaminase inhibition attenuates drug-primed liver hypertrophy but not Mallory body formation.
FEBS letters 2006;580(9):2351--2357.
2006: Chen Alice Y; Schnarr Nathan A; Kim Chu-Young; Cane David E; Khosla Chaitan
Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase.
Journal of the American Chemical Society 2006;128(9):3067-74.
2006: Xia Jiang; Siegel Matthew; Bergseng Elin; Sollid Ludvig M; Khosla Chaitan
Inhibition of HLA-DQ2-mediated antigen presentation by analogues of a high affinity 33-residue peptide from alpha2-gliadin.
Journal of the American Chemical Society 2006;128(6):1859-67.
2006: He Weiguo; Wu Jiaquan; Khosla Chaitan; Cane David E
Macrolactonization to 10-deoxymethynolide catalyzed by the recombinant thioesterase of the picromycin/methymycin polyketide synthase.
Bioorganic & medicinal chemistry letters 2006;16(2):391-4.
2006: Moffet David A; Khosla Chaitan; Cane David E
Modular polyketide synthases: Investigating intermodular communication using 6 deoxyerythronolide B synthase module 2.
Bioorganic & medicinal chemistry letters 2006;16(1):213-6.
2005: Wu Jiaquan; Zaleski Toby J; Valenzano Chiara; Khosla Chaitan; Cane David E
Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase.
Journal of the American Chemical Society 2005;127(49):17393-404.
2005: Gass Jonathan; Ehren Jennifer; Strohmeier Gregg; Isaacs Indu; Khosla Chaitan
Fermentation, purification, formulation, and pharmacological evaluation of a prolyl endopeptidase from Myxococcus xanthus: implications for Celiac Sprue therapy.
Biotechnology and bioengineering 2005;92(6):674-84.
2005: Wu Jiaquan; He Weiguo; Khosla Chaitan; Cane David E
Chain elongation, macrolactonization, and hydrolysis of natural and reduced hexaketide substrates by the picromycin/methymycin polyketide synthase.
Angewandte Chemie (International ed. in English) 2005;44(46):7557-60.
2005: Lee Taek Soon; Khosla Chaitan; Tang Yi
Orthogonal protein interactions in spore pigment producing and antibiotic producing polyketide synthases.
The Journal of antibiotics 2005;58(10):663-6.
2005: Khosla Chaitan; Gray Gary M; Sollid Ludvig M
Putative efficacy and dosage of prolyl endopeptidase for digesting and detoxifying gliadin peptides.
Gastroenterology 2005;129(4):1362-3; author reply 1363.
2005: Shan Lu; Qiao Shuo-Wang; Arentz-Hansen Helene; Molberg Øyvind; Gray Gary M; Sollid Ludvig M; Khosla Chaitan
Identification and analysis of multivalent proteolytically resistant peptides from gluten: implications for celiac sprue.
Journal of proteome research 2005;4(5):1732-41.
2005: Yuan Liya; Choi Kihang; Khosla Chaitan; Zheng Xiao; Higashikubo Ryuji; Chicoine Michael R; Rich Keith M
Tissue transglutaminase 2 inhibition promotes cell death and chemosensitivity in glioblastomas.
Molecular cancer therapeutics 2005;4(9):1293-302.
2005: Lee Taek Soon; Khosla Chaitan; Tang Yi
Engineered biosynthesis of aklanonic acid analogues.
Journal of the American Chemical Society 2005;127(35):12254-62.
2005: Schnarr Nathan A; Chen Alice Y; Cane David E; Khosla Chaitan
Analysis of covalently bound polyketide intermediates on 6-deoxyerythronolide B synthase by tandem proteolysis-mass spectrometry.
Biochemistry 2005;44(35):11836-42.
2005: Schnarr Nathan A; Khosla Chaitan
Biological chemistry: just add chlorine.
Nature 2005;436(7054):1094-5.
2005: Hartung Ingo V; Rude Mathew A; Schnarr Nathan A; Hunziker Daniel; Khosla Chaitan
Stereochemical assignment of intermediates in the rifamycin biosynthetic pathway by precursor-directed biosynthesis.
Journal of the American Chemical Society 2005;127(32):11202-3.
2005: Pyle Gail G; Paaso Brian; Anderson Barbara E; Allen Diane D; Marti Thomas; Li Qing; Siegel Matthew; Khosla Chaitan; Gray Gary M
Effect of pretreatment of food gluten with prolyl endopeptidase on gluten-induced malabsorption in celiac sprue.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2005;3(7):687-94.
2005: Pyle Gail G; Paaso Brian; Anderson Barbara E; Allen Diane; Marti Thomas; Khosla Chaitan; Gray Gary M
Low-dose gluten challenge in celiac sprue: malabsorptive and antibody responses.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2005;3(7):679-86.
2005: Bergseng Elin; Xia Jiang; Kim Chu-Young; Khosla Chaitan; Sollid Ludvig M
Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the celiac disease-associated HLA-DQ2 molecule.
The Journal of biological chemistry 2005;280(23):21791-6.
2005: Choi Kihang; Siegel Matthew; Piper Justin L; Yuan Liya; Cho Eun; Strnad Pavel; Omary Bishr; Rich Keith M; Khosla Chaitan
Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2.
Chemistry & biology 2005;12(4):469-75.
2005: Khosla Chaitan; Tang Yi
Chemistry. A new route to designer antibiotics.
Science (New York, N.Y.) 2005;308(5720):367-8.
2005: Sollid Ludvig M; Khosla Chaitan
Future therapeutic options for celiac disease.
Nature clinical practice. Gastroenterology & hepatology 2005;2(3):140-7.
2005: Xia Jiang; Sollid Ludvig M; Khosla Chaitan
Equilibrium and kinetic analysis of the unusual binding behavior of a highly immunogenic gluten peptide to HLA-DQ2.
Biochemistry 2005;44(11):4442-9.
2005: Shan Lu; Mathews Irimpan I; Khosla Chaitan
Structural and mechanistic analysis of two prolyl endopeptidases: role of interdomain dynamics in catalysis and specificity.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(10):3599-604.
2005: Qiao Shuo-Wang; Piper Justin; Haraldsen Guttorm; Oynebråten Inger; Fleckenstein Burkhard; Molberg Oyvind; Khosla Chaitan; Sollid Ludvig M
Tissue transglutaminase-mediated formation and cleavage of histamine-gliadin complexes: biological effects and implications for celiac disease.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1657-63.
2005: Marti Thomas; Molberg Oyvind; Li Qing; Gray Gary M; Khosla Chaitan; Sollid Ludvig M
Prolyl endopeptidase-mediated destruction of T cell epitopes in whole gluten: chemical and immunological characterization.
The Journal of pharmacology and experimental therapeutics 2005;312(1):19-26.
2004: Wu Jiaquan; Kinoshita Kenji; Khosla Chaitan; Cane David E
Biochemical analysis of the substrate specificity of the beta-ketoacyl-acyl carrier protein synthase domain of module 2 of the erythromycin polyketide synthase.
Biochemistry 2004;43(51):16301-10.
2004: Diacovich Lautaro; Mitchell Deborah Lynn; Pham Huy; Gago Gabriela; Melgar Melrose Mendoza; Khosla Chaitan; Gramajo Hugo; Tsai Shiou-Chuan
Crystal structure of the beta-subunit of acyl-CoA carboxylase: structure-based engineering of substrate specificity.
Biochemistry 2004;43(44):14027-36.
2004: Kim Chu-Young; Alekseyev Viktor Y; Chen Alice Y; Tang Yinyan; Cane David E; Khosla Chaitan
Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase.
Biochemistry 2004;43(44):13892-8.
2004: Shan Lu; Marti Thomas; Sollid Ludvig M; Gray Gary M; Khosla Chaitan
Comparative biochemical analysis of three bacterial prolyl endopeptidases: implications for coeliac sprue.
The Biochemical journal 2004;383(Pt 2):311-8.
2004: Piper Justin L; Gray Gary M; Khosla Chaitan
Effect of prolyl endopeptidase on digestive-resistant gliadin peptides in vivo.
The Journal of pharmacology and experimental therapeutics 2004;311(1):213-9.
2004: Keatinge-Clay Adrian T; Maltby David A; Medzihradszky Katalin F; Khosla Chaitan; Stroud Robert M
An antibiotic factory caught in action.
Nature structural & molecular biology 2004;11(9):888-93.
2004: Lee Ho Young; Chung Hak Suk; Hang Chao; Khosla Chaitan; Walsh Christopher T; Kahne Daniel; Walker Suzanne
Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway.
Journal of the American Chemical Society 2004;126(32):9924-5.
2004: Qiao Shuo-Wang; Bergseng Elin; Molberg Øyvind; Xia Jiang; Fleckenstein Burkhard; Khosla Chaitan; Sollid Ludvig M
Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1757-62.
2004: Tang Yi; Koppisch Andrew T; Khosla Chaitan
The acyltransferase homologue from the initiation module of the R1128 polyketide synthase is an acyl-ACP thioesterase that edits acetyl primer units.
Biochemistry 2004;43(29):9546-55.
2004: Boddy Christopher N; Hotta Kinya; Tse Martha Lovato; Watts R Edward; Khosla Chaitan
Precursor-directed biosynthesis of epothilone in Escherichia coli.
Journal of the American Chemical Society 2004;126(24):7436-7.
2004: Kim Chu-Young; Quarsten Hanne; Bergseng Elin; Khosla Chaitan; Sollid Ludvig M
Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(12):4175-9.
2004: Tang Yi; Lee Taek Soon; Khosla Chaitan
Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthases.
PLoS biology 2004;2(2):E31.
2004: Kumar Pawan; Khosla Chaitan; Tang Yi
Manipulation and analysis of polyketide synthases.
Methods in enzymology 2004;388():269-93.
2003: Khosla Chaitan; Keasling Jay D
Metabolic engineering for drug discovery and development.
Nature reviews. Drug discovery 2003;2(12):1019-25.
2003: Kumar Pawan; Koppisch Andrew T; Cane David E; Khosla Chaitan
Enhancing the modularity of the modular polyketide synthases: transacylation in modular polyketide synthases catalyzed by malonyl-CoA:ACP transacylase.
Journal of the American Chemical Society 2003;125(47):14307-12.
2003: Watanabe Kenji; Khosla Chaitan; Stroud Robert M; Tsai Shiou Chuan
Crystal structure of an Acyl-ACP dehydrogenase from the FK520 polyketide biosynthetic pathway: insights into extender unit biosynthesis.
Journal of molecular biology 2003;334(3):435-44.
2003: Pfeifer Blaine A; Wang Clay C C; Walsh Christopher T; Khosla Chaitan
Biosynthesis of Yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host.
Applied and environmental microbiology 2003;69(11):6698-702.
2003: Admiraal Suzanne J; Khosla Chaitan; Walsh Christopher T
A Switch for the transfer of substrate between nonribosomal peptide and polyketide modules of the rifamycin synthetase assembly line.
Journal of the American Chemical Society 2003;125(45):13664-5.
2003: Kinoshita Kenji; Pfeifer Blaine A; Khosla Chaitan; Cane David E
Precursor-Directed polyketide biosynthesis in Escherichia coli.
Bioorganic & medicinal chemistry letters 2003;13(21):3701-4.
2003: Tang Yi; Tsai Shiou-Chuan; Khosla Chaitan
Polyketide chain length control by chain length factor.
Journal of the American Chemical Society 2003;125(42):12708-9.
2003: Watanabe Kenji; Wang Clay C C; Boddy Christopher N; Cane David E; Khosla Chaitan
Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases.
The Journal of biological chemistry 2003;278(43):42020-6.
2003: Koppisch Andrew T; Khosla Chaitan
Structure-based mutagenesis of the malonyl-CoA:acyl carrier protein transacylase from Streptomyces coelicolor.
Biochemistry 2003;42(37):11057-64.
2003: Hu Zhihao; Pfeifer Blaine A; Chao Elizabeth; Murli Sumati; Kealey Jim; Carney John R; Ashley Gary; Khosla Chaitan; Hutchinson C Richard
A specific role of the Saccharopolyspora erythraea thioesterase II gene in the function of modular polyketide synthases.
Microbiology (Reading, England) 2003;149(Pt 8):2213-25.
2003: Watanabe Kenji; Rude Mathew A; Walsh Christopher T; Khosla Chaitan
Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(17):9774-8.
2003: Tang Yi; Lee Taek Soon; Kobayashi Seiji; Khosla Chaitan
Ketosynthases in the initiation and elongation modules of aromatic polyketide synthases have orthogonal acyl carrier protein specificity.
Biochemistry 2003;42(21):6588-95.
2003: Yin Yifeng; Lu Hongxiang; Khosla Chaitan; Cane David E
Expression and kinetic analysis of the substrate specificity of modules 5 and 6 of the picromycin/methymycin polyketide synthase.
Journal of the American Chemical Society 2003;125(19):5671-6.
2003: Hans Marcus; Hornung Andreas; Dziarnowski Agnieszka; Cane David E; Khosla Chaitan
Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules.
Journal of the American Chemical Society 2003;125(18):5366-74.
2003: Liou Grace F; Khosla Chaitan
Building-block selectivity of polyketide synthases.
Current opinion in chemical biology 2003;7(2):279-84.
2003: Li Qing; Khosla Chaitan; Puglisi Joseph D; Liu Corey W
Solution structure and backbone dynamics of the holo form of the frenolicin acyl carrier protein.
Biochemistry 2003;42(16):4648-57.
2003: Kumar Pawan; Li Qing; Cane David E; Khosla Chaitan
Intermodular communication in modular polyketide synthases: structural and mutational analysis of linker mediated protein-protein recognition.
Journal of the American Chemical Society 2003;125(14):4097-102.
2003: Hausch Felix; Halttunen Tuula; Mäki Markku; Khosla Chaitan
Design, synthesis, and evaluation of gluten peptide analogs as selective inhibitors of human tissue transglutaminase.
Chemistry & biology 2003;10(3):225-31.
2003: Boddy Christopher N; Schneider Tanya L; Hotta Kinya; Walsh Christopher T; Khosla Chaitan
Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase.
Journal of the American Chemical Society 2003;125(12):3428-9.
2003: Keatinge-Clay Adrian T; Shelat Anang A; Savage David F; Tsai Shiou Chuan; Miercke Larry J W; O'Connell Joseph D; Khosla Chaitan; Stroud Robert M
Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase.
Structure (London, England : 1993) 2003;11(2):147-54.
2003: Liou Grace F; Lau Janice; Cane David E; Khosla Chaitan
Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases.
Biochemistry 2003;42(1):200-7.
2002: Pan Hu; Tsai Shiou chuan; Meadows Eric S; Miercke Larry J W; Keatinge-Clay Adrian T; O'Connell Joe; Khosla Chaitan; Stroud Robert M
Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway.
Structure (London, England : 1993) 2002;10(11):1559-68.
2002: Parrot Isabelle; Huang Philip C; Khosla Chaitan
Circular dichroism and nuclear magnetic resonance spectroscopic analysis of immunogenic gluten peptides and their analogs.
The Journal of biological chemistry 2002;277(47):45572-8.
2002: Tsai Shiou-Chuan; Lu Hongxiang; Cane David E; Khosla Chaitan; Stroud Robert M
Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases.
Biochemistry 2002;41(42):12598-606.
2002: Lu Hongxiang; Tsai Shiou-Chuan; Khosla Chaitan; Cane David E
Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase.
Biochemistry 2002;41(42):12590-7.
2002: Hausch Felix; Shan Lu; Santiago Nilda A; Gray Gary M; Khosla Chaitan
Intestinal digestive resistance of immunodominant gliadin peptides.
American journal of physiology. Gastrointestinal and liver physiology 2002;283(4):G996-G1003.
2002: Shan Lu; Molberg Øyvind; Parrot Isabelle; Hausch Felix; Filiz Ferda; Gray Gary M; Sollid Ludvig M; Khosla Chaitan
Structural basis for gluten intolerance in celiac sprue.
Science (New York, N.Y.) 2002;297(5590):2275-9.
2002: Dordick Jonathan S; Khosla Chaitan
Engineering of molecular and cellular biocatalysts: selected contributions by James E. Bailey.
Biotechnology and bioengineering 2002;79(5):490-5.
2002: Diacovich Lautaro; Peirú Salvador; Kurth Daniel; Rodríguez Eduardo; Podestá Florencio; Khosla Chaitan; Gramajo Hugo
Kinetic and structural analysis of a new group of Acyl-CoA carboxylases found in Streptomyces coelicolor A3(2).
The Journal of biological chemistry 2002;277(34):31228-36.
2002: Pfeifer Blaine; Hu Zhihao; Licari Peter; Khosla Chaitan
Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B.
Applied and environmental microbiology 2002;68(7):3287-92.
2002: Admiraal Suzanne J; Khosla Chaitan; Walsh Christopher T
The loading and initial elongation modules of rifamycin synthetase collaborate to produce mixed aryl ketide products.
Biochemistry 2002;41(16):5313-24.
2002: Dayem Linda C; Carney John R; Santi Daniel V; Pfeifer Blaine A; Khosla Chaitan; Kealey James T
Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli.
Biochemistry 2002;41(16):5193-201.
2002: Wu Nicholas; Cane David E; Khosla Chaitan
Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases.
Biochemistry 2002;41(15):5056-66.
2002: Cane David E; Kudo Fumitaka; Kinoshita Kenji; Khosla Chaitan
Precursor-directed biosynthesis: biochemical basis of the remarkable selectivity of the erythromycin polyketide synthase toward unsaturated triketides.
Chemistry & biology 2002;9(1):131-42.
2002: Piper Justin L; Gray Gary M; Khosla Chaitan
High selectivity of human tissue transglutaminase for immunoactive gliadin peptides: implications for celiac sprue.
Biochemistry 2002;41(1):386-93.
2001: Tsai S C; Miercke L J; Krucinski J; Gokhale R; Chen J C; Foster P G; Cane D E; Khosla C; Stroud R M
Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):14808-13.
2001: Meadows E S; Khosla C
In vitro reconstitution and analysis of the chain initiating enzymes of the R1128 polyketide synthase.
Biochemistry 2001;40(49):14855-61.
2001: Dreier J; Li Q; Khosla C
Malonyl-CoA:ACP transacylase from Streptomyces coelicolor has two alternative catalytically active nucleophiles.
Biochemistry 2001;40(41):12407-11.
2001: Lombó F; Pfeifer B; Leaf T; Ou S; Kim Y S; Cane D E; Licari P; Khosla C
Enhancing the atom economy of polyketide biosynthetic processes through metabolic engineering.
Biotechnology progress 2001;17(4):612-7.
2001: Chiu H T; Hubbard B K; Shah A N; Eide J; Fredenburg R A; Walsh C T; Khosla C
Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8548-53.
2001: Wu N; Tsuji S Y; Cane D E; Khosla C
Assessing the balance between protein-protein interactions and enzyme-substrate interactions in the channeling of intermediates between polyketide synthase modules.
Journal of the American Chemical Society 2001;123(27):6465-74.
2001: Yin Y; Gokhale R; Khosla C; Cane D E
Erythromycin biosynthesis. The 4-pro-S hydride of NADPH is utilized for ketoreduction by both module 5 and module 6 of the 6-deoxyerythronolide B synthase.
Bioorganic & medicinal chemistry letters 2001;11(12):1477-9.
2001: Pohl N L; Hans M; Lee H Y; Kim Y S; Cane D E; Khosla C
Remarkably broad substrate tolerance of malonyl-CoA synthetase, an enzyme capable of intracellular synthesis of polyketide precursors.
Journal of the American Chemical Society 2001;123(24):5822-3.
2001: Admiraal S J; Walsh C T; Khosla C
The loading module of rifamycin synthetase is an adenylation-thiolation didomain with substrate tolerance for substituted benzoates.
Biochemistry 2001;40(20):6116-23.
2001: Kinoshita K; Williard P G; Khosla C; Cane D E
Precursor-directed biosynthesis of 16-membered macrolides by the erythromycin polyketide synthase.
Journal of the American Chemical Society 2001;123(11):2495-502.
2001: Pfeifer B A; Khosla C
Biosynthesis of polyketides in heterologous hosts.
Microbiology and molecular biology reviews : MMBR 2001;65(1):106-18.
2001: Pfeifer B A; Admiraal S J; Gramajo H; Cane D E; Khosla C
Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli.
Science (New York, N.Y.) 2001;291(5509):1790-2.
2001: Tsuji S Y; Cane D E; Khosla C
Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules.
Biochemistry 2001;40(8):2326-31.
2001: Tsuji S Y; Wu N; Khosla C
Intermodular communication in polyketide synthases: comparing the role of protein-protein interactions to those in other multidomain proteins.
Biochemistry 2001;40(8):2317-25.
2001: Salomon A R; Zhang Y; Seto H; Khosla C
Structure-activity relationships within a family of selectively cytotoxic macrolide natural products.
Organic letters 2001;3(1):57-9.
2001: Khosla C; Harbury P B
Modular enzymes.
Nature 2001;409(6817):247-52.
2001: Salomon A R; Voehringer D W; Herzenberg L A; Khosla C
Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase.
Chemistry & biology 2001;8(1):71-80.
2000: Salomon A R; Voehringer D W; Herzenberg L A; Khosla C
Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14766-71.
2000: Khosla C
Natural product biosynthesis: a new interface between enzymology and medicine.
The Journal of organic chemistry 2000;65(24):8127-33.
2000: Marti T; Hu Z; Pohl N L; Shah A N; Khosla C
Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism.
The Journal of biological chemistry 2000;275(43):33443-8.
2000: Lau J; Cane D E; Khosla C
Substrate specificity of the loading didomain of the erythromycin polyketide synthase.
Biochemistry 2000;39(34):10514-20.
2000: Hu Z; Hopwood D A; Khosla C
Directed transfer of large DNA fragments between Streptomyces species.
Applied and environmental microbiology 2000;66(5):2274-7.
2000: Dreier J; Khosla C
Mechanistic analysis of a type II polyketide synthase. Role of conserved residues in the beta-ketoacyl synthase-chain length factor heterodimer.
Biochemistry 2000;39(8):2088-95.
2000: Gokhale R S; Khosla C
Role of linkers in communication between protein modules.
Current opinion in chemical biology 2000;4(1):22-7.
1999: Hu Z; Hunziker D; Hutchinson C R; Khosla C
A host-vector system for analysis and manipulation of rifamycin polyketide biosynthesis in Amycolatopsis mediterranei.
Microbiology (Reading, England) 1999;145 ( Pt 9)():2335-41.
1999: Zawada R J; Khosla C
Heterologous expression, purification, reconstitution and kinetic analysis of an extended type II polyketide synthase.
Chemistry & biology 1999;6(9):607-15.
1999: Dreier J; Shah A N; Khosla C
Kinetic analysis of the actinorhodin aromatic polyketide synthase.
The Journal of biological chemistry 1999;274(35):25108-12.
1999: Richardson M T; Pohl N L; Kealey J T; Khosla C
Tolerance and specificity of recombinant 6-methylsalicyclic acid synthase.
Metabolic engineering 1999;1(2):180-7.
1999: Gokhale R S; Tsuji S Y; Cane D E; Khosla C
Dissecting and exploiting intermodular communication in polyketide synthases.
Science (New York, N.Y.) 1999;284(5413):482-5.
1999: Gokhale R S; Hunziker D; Cane D E; Khosla C
Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase.
Chemistry & biology 1999;6(2):117-25.
1999: Lau J; Fu H; Cane D E; Khosla C
Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units.
Biochemistry 1999;38(5):1643-51.
1999: Khosla C; Gokhale R S; Jacobsen J R; Cane D E
Tolerance and specificity of polyketide synthases.
Annual review of biochemistry 1999;68():219-53.
1998: Cane D E; Walsh C T; Khosla C
Harnessing the biosynthetic code: combinations, permutations, and mutations.
Science (New York, N.Y.) 1998;282(5386):63-8.
1998: Jacobsen J R; Keatinge-Clay A T; Cane D E; Khosla C
Precursor-directed biosynthesis of 12-ethyl erythromycin.
Bioorganic & medicinal chemistry 1998;6(8):1171-7.
1998: Jacobsen J R; Cane D E; Khosla C
Spontaneous priming of a downstream module in 6-deoxyerythronolide B synthase leads to polyketide biosynthesis.
Biochemistry 1998;37(14):4928-34.
1998: Jacobsen J R; Khosla C
New directions in metabolic engineering.
Current opinion in chemical biology 1998;2(1):133-7.
1998: Carreras C W; Khosla C
Purification and in vitro reconstitution of the essential protein components of an aromatic polyketide synthase.
Biochemistry 1998;37(8):2084-8.
1998: Gokhale R S; Lau J; Cane D E; Khosla C
Functional orientation of the acyltransferase domain in a module of the erythromycin polyketide synthase.
Biochemistry 1998;37(8):2524-8.
1997: Chuck J A; McPherson M; Huang H; Jacobsen J R; Khosla C; Cane D E
Molecular recognition of diketide substrates by a beta-ketoacyl-acyl carrier protein synthase domain within a bimodular polyketide synthase.
Chemistry & biology 1997;4(10):757-66.
1997: McDaniel R; Kao C M; Hwang S J; Khosla C
Engineered intermodular and intramodular polyketide synthase fusions.
Chemistry & biology 1997;4(9):667-74.
1997: Carreras C W; Gehring A M; Walsh C T; Khosla C
Utilization of enzymatically phosphopantetheinylated acyl carrier proteins and acetyl-acyl carrier proteins by the actinorhodin polyketide synthase.
Biochemistry 1997;36(39):11757-61.
1997: Jacobsen J R; Hutchinson C R; Cane D E; Khosla C
Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase.
Science (New York, N.Y.) 1997;277(5324):367-9.
1997: Zawada R J; Khosla C
Domain analysis of the molecular recognition features of aromatic polyketide synthase subunits.
The Journal of biological chemistry 1997;272(26):16184-8.
1997: Pieper R; Gokhale R S; Luo G; Cane D E; Khosla C
Purification and characterization of bimodular and trimodular derivatives of the erythromycin polyketide synthase.
Biochemistry 1997;36(7):1846-51.
1996: Tsukamoto N; Chuck J A; Luo G; Kao C M; Khosla C; Cane D E
6-deoxyerythronolide B synthase 1 is specifically acylated by a diketide intermediate at the beta-ketoacyl-acyl carrier protein synthase domain of module 2.
Biochemistry 1996;35(48):15244-8.
1996: Lambalot R H; Gehring A M; Flugel R S; Zuber P; LaCelle M; Marahiel M A; Reid R; Khosla C; Walsh C T
A new enzyme superfamily - the phosphopantetheinyl transferases.
Chemistry & biology 1996;3(11):923-36.
1996: Khosla C; Caren R; Kao C M; McDaniel R; Wang S W
Evolutionally guided enzyme design.
Biotechnology and bioengineering 1996;52(1):122-8.
1996: Kramer P J; Khosla C
Engineering of novel polyketides. Progress and Prospects.
Annals of the New York Academy of Sciences 1996;799():32-45.
1996: Bedford D; Jacobsen J R; Luo G; Cane D E; Khosla C
A functional chimeric modular polyketide synthase generated via domain replacement.
Chemistry & biology 1996;3(10):827-31.
1996: Kao C M; Pieper R; Cane D E; Khosla C
Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase.
Biochemistry 1996;35(38):12363-8.
1996: Khosla C; Zawada R J
Generation of polyketide libraries via combinatorial biosynthesis.
Trends in biotechnology 1996;14(9):335-41.
1996: Luo G; Pieper R; Rosa A; Khosla C; Cane D E
Erythromycin biosynthesis: exploiting the catalytic versatility of the modular polyketide synthase.
Bioorganic & medicinal chemistry 1996;4(7):995-9.
1996: Fu H; Alvarez M A; Khosla C; Bailey J E
Engineered biosynthesis of novel polyketides: regiospecific methylation of an unnatural substrate by the tcmO O-methyltransferase.
Biochemistry 1996;35(21):6527-32.
1996: Pieper R; Ebert-Khosla S; Cane D; Khosla C
Erythromycin biosynthesis: kinetic studies on a fully active modular polyketide synthase using natural and unnatural substrates.
Biochemistry 1996;35(7):2054-60.
1995: Pieper R; Luo G; Cane D E; Khosla C
Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases.
Nature 1995;378(6554):263-6.
1995: Bedford D J; Schweizer E; Hopwood D A; Khosla C
Expression of a functional fungal polyketide synthase in the bacterium Streptomyces coelicolor A3(2).
Journal of bacteriology 1995;177(15):4544-8.
1995: Cane D E; Luo G; Khosla C; Kao C M; Katz L
Erythromycin biosynthesis. Highly efficient incorporation of polyketide chain elongation intermediates into 6-deoxyerythronolide B in an engineered Streptomyces host.
The Journal of antibiotics 1995;48(7):647-51.
1995: Tsoi C J; Khosla C
Combinatorial biosynthesis of 'unnatural' natural products: the polyketide example.
Chemistry & biology 1995;2(6):355-62.
1995: McDaniel R; Ebert-Khosla S; Hopwood D A; Khosla C
Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits.
Nature 1995;375(6532):549-54.
1994: Fu H; Hopwood D A; Khosla C
Engineered biosynthesis of novel polyketides: evidence for temporal, but not regiospecific, control of cyclization of an aromatic polyketide precursor.
Chemistry & biology 1994;1(4):205-10.
1994: McDaniel R; Ebert-Khosla S; Fu H; Hopwood D A; Khosla C
Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(24):11542-6.
1994: Fu H; McDaniel R; Hopwood D A; Khosla C
Engineered biosynthesis of novel polyketides: stereochemical course of two reactions catalyzed by a polyketide synthase.
Biochemistry 1994;33(31):9321-6.
1994: Kao C M; Katz L; Khosla C
Engineered biosynthesis of a complete macrolactone in a heterologous host.
Science (New York, N.Y.) 1994;265(5171):509-12.
1993: McDaniel R; Ebert-Khosla S; Hopwood D A; Khosla C
Engineered biosynthesis of novel polyketides.
Science (New York, N.Y.) 1993;262(5139):1546-50.
1993: Khosla C; McDaniel R; Ebert-Khosla S; Torres R; Sherman D H; Bibb M J; Hopwood D A
Genetic construction and functional analysis of hybrid polyketide synthases containing heterologous acyl carrier proteins.
Journal of bacteriology 1993;175(8):2197-204.
1992: Khosla C; Ebert-Khosla S; Hopwood D A
Targeted gene replacements in a Streptomyces polyketide synthase gene cluster: role for the acyl carrier protein.
Molecular microbiology 1992;6(21):3237-49.
1992: Hopwood D A; Khosla C
Genes for polyketide secondary metabolic pathways in microorganisms and plants.
Ciba Foundation symposium 1992;171():88-106; discussion 106-12.

Sign-in to see more

Sign-in free and Explore the Exciting World of BiomedExperts:

NetworkView

Chaitan Khosla

Research Profile (preview)

Chemicals & Drugs

Living Beings

Concepts & Ideas

Genes & Molecular Sequences

Disorders

Procedures

Network (preview)

Publications

Sign in free and see...

Visualized networks:

GeoTargeted Searches:

Research Profiles:

Geonetwork of Chaitan Khosla (preview)

All Publications