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Antoine Kichler

Research Profile

Chemicals & Drugs

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Gene Transfer Techniques

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Publications

TOP 3
David Fenard; Anne Galy; Sandrine Genries; Samia Martin; Daniel Scherman; Antoine Kichler
Infectivity enhancement of different HIV-1-based lentiviral pseudotypes in presence of the cationic amphipathic peptide LAH4-L1.
David Fenard; Julien Buisset; Sandrine Genries; Dina Ingrao; Antoine Kichler; Samia Martin; Ababacar Seye; Anne Galy
Vectofusin-1, a new viral entry enhancer, strongly promotes lentiviral transduction of human hematopoietic stem cells.
Antoine Kichler; Arnaud Marquette; A James Mason; Burkhard Bechinger
Histidine-rich cationic amphipathic peptides for plasmid DNA and siRNA delivery.

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All Publications

2013: David Fenard; Anne Galy; Sandrine Genries; Samia Martin; Daniel Scherman; Antoine Kichler
Infectivity enhancement of different HIV-1-based lentiviral pseudotypes in presence of the cationic amphipathic peptide LAH4-L1.
Journal of virological methods 2013;189(2):375-8.
2013: David Fenard; Julien Buisset; Sandrine Genries; Dina Ingrao; Antoine Kichler; Samia Martin; Ababacar Seye; Anne Galy
Vectofusin-1, a new viral entry enhancer, strongly promotes lentiviral transduction of human hematopoietic stem cells.
Molecular therapy. Nucleic acids 2013;2():e90.
2013: Antoine Kichler; Arnaud Marquette; A James Mason; Burkhard Bechinger
Histidine-rich cationic amphipathic peptides for plasmid DNA and siRNA delivery.
Methods in molecular biology (Clifton, N.J.) 2013;948():85-103.
2012: Simon Guiraud; Daniel Scherman; Laetitia van Wittenberghe; Christophe Georger; Antoine Kichler
Identification of decorin derived peptides with a zinc dependent anti-myostatin activity.
Neuromuscular disorders : NMD 2012;22(12):1057-68.
2012: Valentina Iacobucci; Antoine Kichler; Tam T. T. Bui; Francesca Di Giuseppe; Alex F Drake; Jayneil Patel; Daniel Scherman; Louic S Vermeer; A James Mason
Control of pH responsive peptide self-association during endocytosis is required for effective gene transfer.
Biochimica et biophysica acta 2012;1818(5):1332-41.
2012: Véronique Wintgens; Sonia Baconnais; Virginie Burckbuchler; Antoine Kichler; Eric Le Cam; Christian Leborgne; Daniel Scherman; Catherine Amiel
Smart DNA vectors based on cyclodextrin polymers: compaction and endosomal release.
Pharmaceutical research 2012;29(2):384-96.
2012: Xavier GERARD; Sylvain Hanein; Josseline Kaplan; Antoine Kichler; Arnold Munnich; Isabelle Perrault; Marlène Rio; Karine Bigot; Sabine Defoort-Delhemmes; Daniel Scherman; Eduardo Silva; Jean-Michel Rozet
AON-mediated Exon Skipping Restores Ciliation in Fibroblasts Harboring the Common Leber Congenital Amaurosis CEP290 Mutation.
Molecular therapy. Nucleic acids 2012;1():e29.
2011: Simon Guiraud; Debborah Alimi-Guez; Laetitia van Wittenberghe; Daniel Scherman; Antoine Kichler
The reverse block copolymer Pluronic 25R2 promotes DNA transfection of skeletal muscle.
Macromolecular bioscience 2011;11(5):590-4.
2011: Blandine Brissault; Christian Leborgne; Daniel Scherman; Christine Guis; Antoine Kichler
Synthesis of poly(propylene glycol)-block-polyethylenimine triblock copolymers for the delivery of nucleic acids.
Macromolecular bioscience 2011;11(5):652-61.
2011: Burkhard Bechinger; Verica Vidovic; Philippe Bertani; Antoine Kichler
A new family of peptide-nucleic acid nanostructures with potent transfection activities.
Journal of peptide science : an official publication of the European Peptide Society 2011;17(2):88-93.
2010: Gilles Moulay; Daniel Scherman; Antoine Kichler
Fasting increases the in vivo gene delivery of AAV vectors.
Clinical and translational science 2010;3(6):333-6.
2010: Nathalie Lidgi-Guigui; Christine Guis; Blandine Brissault; Antoine Kichler; Christian Leborgne; Daniel Scherman; Sid Labdi; Patrick A Curmi
Investigation of DNA condensing properties of amphiphilic triblock cationic polymers by atomic force microscopy.
Langmuir : the ACS journal of surfaces and colloids 2010;26(22):17552-7.
2010: Bérangère Langlet-Bertin; Christian Leborgne; Daniel Scherman; Burkhard Bechinger; A James Mason; Antoine Kichler
Design and evaluation of histidine-rich amphipathic peptides for siRNA delivery.
Pharmaceutical research 2010;27(7):1426-36.
2010: Yun Lan; Bérangère Langlet-Bertin; Vincenzo Abbate; Louic S Vermeer; Xiaole Kong; Kelly E Sullivan; Christian Leborgne; Daniel Scherman; Robert C Hider; Alex F Drake; Sukhvinder S Bansal; Antoine Kichler; A James Mason
Incorporation of 2,3-diaminopropionic acid into linear cationic amphipathic peptides produces pH-sensitive vectors.
Chembiochem : a European journal of chemical biology 2010;11(9):1266-72.
2010: Kristl G Claeys; Magdalena Sozanska; Jean-Jacques Martin; Emmanuelle Lacene; Ludivine Vignaud; Daniel Stockholm; Pascal Laforêt; Bruno Eymard; Antoine Kichler; Daniel Scherman; Thomas Voit; David Israeli
DNAJB2 expression in normal and diseased human and mouse skeletal muscle.
The American journal of pathology 2010;176(6):2901-10.
2010: Emmanuel Klein; Christian Leborgne; Miahala Ciobanu; Jérôme Klein; Benoît Frisch; Françoise Pons; Guy Zuber; Daniel Scherman; Antoine Kichler; Luc Lebeau
Nucleic acid transfer with hemifluorinated polycationic lipids.
Biomaterials 2010;31(17):4781-8.
2010: Emmanuel Klein; Miahala Ciobanu; Jérôme Klein; Valérie Machi; Christian Leborgne; Thierry Vandamme; Benoît Frisch; Françoise Pons; Antoine Kichler; Guy Zuber; Luc Lebeau
"HFP" fluorinated cationic lipids for enhanced lipoplex stability and gene delivery.
Bioconjugate chemistry 2010;21(2):360-71.
2010: Gilles Moulay; Sylvie Boutin; Carole Masurier; Daniel Scherman; Antoine Kichler
Polymers for improving the in vivo transduction efficiency of AAV2 vectors.
PloS one 2010;5(12):e15576.
2009: Debborah Alimi-Guez; Christian Leborgne; Gaelle Pembouong; Laetitia Van Wittenberghe; Nathalie MIGNET; Daniel Scherman; Antoine Kichler
Evaluation of the muscle gene transfer activity of a series of amphiphilic triblock copolymers.
The journal of gene medicine 2009;11(12):1114-24.
2009: A James Mason; Wardi Moussaoui; Tamer Abdelrahman; Alyae Boukhari; Philippe Bertani; Arnaud Marquette; Peiman Shooshtarizaheh; Gilles Moulay; Nelly Boehm; Bernard Guerold; Ruairidh J H Sawers; Antoine Kichler; Marie-Hélène Metz-Boutigue; Ermanno Candolfi; Gilles Prévost; Burkhard Bechinger
Structural determinants of antimicrobial and antiplasmodial activity and selectivity in histidine-rich amphipathic cationic peptides.
The Journal of biological chemistry 2009;284(1):119-33.
2009: Xavier Leclerc; Olivier Danos; Daniel Scherman; Antoine Kichler
A comparison of synthetic oligodeoxynucleotides, DNA fragments and AAV-1 for targeted episomal and chromosomal gene repair.
BMC biotechnology 2009;9():35.
2008: Catherine Pomel; Christian Leborgne; Hervé Cheradame; Daniel Scherman; Antoine Kichler; Philippe Guegan
Synthesis and evaluation of amphiphilic poly(tetrahydrofuran-b-ethylene oxide) copolymers for DNA delivery into skeletal muscle.
Pharmaceutical research 2008;25(12):2963-71.
2007: A James Mason; Philippe Bertani; Gilles Moulay; Arnaud Marquette; Barbara Perrone; Alex F Drake; Antoine Kichler; Burkhard Bechinger
Membrane interaction of chrysophsin-1, a histidine-rich antimicrobial peptide from red sea bream.
Biochemistry 2007;46(51):15175-87.
2007: Lydia Prongidi-Fix; Masae Sugawara; Philippe Bertani; Jésus Raya; Christian Leborgne; Antoine Kichler; Burkhard Bechinger
Self-promoted cellular uptake of peptide/DNA transfection complexes.
Biochemistry 2007;46(40):11253-62.
2007: Blandine Brissault; Antoine Kichler; Christian Leborgne; Nathalie Jarroux; Hervé Cheradame; Christine Guis
Amphiphilic poly[(propylene glycol)-block-(2-methyl-2-oxazoline)] copolymers for gene transfer in skeletal muscle.
ChemMedChem 2007;2(8):1202-7.
2007: A James Mason; Burkhard Bechinger; Antoine Kichler
Rational design of vector and antibiotic peptides using solid-state NMR.
Mini reviews in medicinal chemistry 2007;7(5):491-7.
2007: A James Mason; Christian Leborgne; Gilles Moulay; Amélie Martinez; Olivier Danos; Burkhard Bechinger; Antoine Kichler
Optimising histidine rich peptides for efficient DNA delivery in the presence of serum.
Journal of controlled release : official journal of the Controlled Release Society 2007;118(1):95-104.
2007: Antoine Kichler; Christian Leborgne; Olivier Danos; Burkhard Bechinger
Characterization of the gene transfer process mediated by histidine-rich peptides.
Journal of molecular medicine (Berlin, Germany) 2007;85(2):191-201.
2006: Blandine Brissault; Antoine Kichler; Christian Leborgne; Olivier Danos; Hervé Cheradame; J Gau; Loïc Auvray; Christine Guis
Synthesis, characterization, and gene transfer application of poly(ethylene glycol-b-ethylenimine) with high molar mass polyamine block.
Biomacromolecules 2006;7(10):2863-70.
2006: A James Mason; Claire Gasnier; Antoine Kichler; Gilles Prévost; Dominique Aunis; Marie-Hélène Metz-Boutigue; Burkhard Bechinger
Enhanced membrane disruption and antibiotic action against pathogenic bacteria by designed histidine-rich peptides at acidic pH.
Antimicrobial agents and chemotherapy 2006;50(10):3305-11.
2006: Blandine Brissault; Christian Leborgne; Christine Guis; Olivier Danos; Hervé Cheradame; Antoine Kichler
Linear topology confers in vivo gene transfer activity to polyethylenimines.
Bioconjugate chemistry 2006;17(3):759-65.
2006: Virginie Burckbuchler; Véronique Wintgens; Sophie LECOMTE; A Percot; Christian Leborgne; O Danos; Antoine Kichler; Catherine Amiel
DNA compaction into new DNA vectors based on cyclodextrin polymer: surface enhanced Raman spectroscopy characterization.
Biopolymers 2006;81(5):360-70.
2006: Antoine Kichler; A James Mason; Burkhard Bechinger
Cationic amphipathic histidine-rich peptides for gene delivery.
Biochimica et biophysica acta 2006;1758(3):301-7.
2006: A James Mason; Amélie Martinez; Clemens Glaubitz; Olivier Danos; Antoine Kichler; Burkhard Bechinger
The antibiotic and DNA-transfecting peptide LAH4 selectively associates with, and disorders, anionic lipids in mixed membranes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(2):320-2.
2005: Antoine Kichler; Christian Leborgne; Olivier Danos
Dilution of reporter gene with stuffer DNA does not alter the transfection efficiency of polyethylenimines.
The journal of gene medicine 2005;7(11):1459-67.
2005: Antoine Kichler; Christian Leborgne; Paul B Savage; Olivier Danos
Cationic steroid antibiotics demonstrate DNA delivery properties.
Journal of controlled release : official journal of the Controlled Release Society 2005;107(1):174-82.
2004: Antoine Kichler
Gene transfer with modified polyethylenimines.
The journal of gene medicine 2004;6 Suppl 1():S3-10.
2003: Antoine Kichler; Nicolas Sabourault; Rachel Décor; Christian Leborgne; Marc Schmutz; Alain Valleix; Olivier Danos; Alain Wagner; Charles Mioskowski
Preparation and evaluation of a new class of gene transfer reagents: poly(-alkylaminosiloxanes).
Journal of controlled release : official journal of the Controlled Release Society 2003;93(3):403-14.
2003: Antoine Kichler; Burkhard Bechinger; Olivier Danos
[Antimicrobial peptides as efficient DNA vectors].
Médecine sciences : M/S 2003;19(11):1046-7.
2003: Emmanuel Coeytaux; Dominique Coulaud; Eric Le Cam; Olivier Danos; Antoine Kichler
The cationic amphipathic alpha-helix of HIV-1 viral protein R (Vpr) binds to nucleic acids, permeabilizes membranes, and efficiently transfects cells.
The Journal of biological chemistry 2003;278(20):18110-6.
2003: Blandine Brissault; Antoine Kichler; Christine Guis; Christian Leborgne; Olivier Danos; Hervé Cheradame
Synthesis of linear polyethylenimine derivatives for DNA transfection.
Bioconjugate chemistry 2003;14(3):581-7.
2003: Antoine Kichler; Christian Leborgne; Josefine März; Olivier Danos; Burkhard Bechinger
Histidine-rich amphipathic peptide antibiotics promote efficient delivery of DNA into mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1564-8.
2002: Antoine Kichler; Miguel Chillon; Christian Leborgne; Olivier Danos; Benoît Frisch
Intranasal gene delivery with a polyethylenimine-PEG conjugate.
Journal of controlled release : official journal of the Controlled Release Society 2002;81(3):379-88.
2001: Antoine Kichler; Christian Leborgne; E Coeytaux; Olivier Danos
Polyethylenimine-mediated gene delivery: a mechanistic study.
The journal of gene medicine 2001;3(2):135-44.
2000: Antoine Kichler; J C Pages; Christian Leborgne; Sabine Druillennec; Christine Lenoir; Dominique Coulaud; Etienne Delain; Eric Le Cam; Bernard P Roques; Olivier Danos
Efficient DNA transfection mediated by the C-terminal domain of human immunodeficiency virus type 1 viral protein R.
Journal of virology 2000;74(12):5424-31.