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Valerie Kickhoefer

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Leonard H Rome; Valerie A Kickhoefer
Development of the vault particle as a platform technology.
Jian Yang; Valerie A Kickhoefer; Jan Mrazek; Zhanyong Shu; Aswin Srinivasan; Yang Sun; Leonard H Rome
Vault nanoparticles engineered with the protein transduction domain, TAT48, enhances cellular uptake.
Upendra K Kar; Cheryl I Champion; Janina Jiang; Valerie A Kickhoefer; Kayvan R Niazi; Shahrooz Rabizadeh; Leonard H Rome; Sahar Salehi; Sherven Sharma; Minu Srivastava; Kathleen A Kelly
Vault nanocapsules as adjuvants favor cell-mediated over antibody-mediated immune responses following immunization of mice.

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All Publications

2013: Leonard H Rome; Valerie A Kickhoefer
Development of the vault particle as a platform technology.
ACS nano 2013;7(2):889-902.
2013: Jian Yang; Valerie A Kickhoefer; Jan Mrazek; Zhanyong Shu; Aswin Srinivasan; Yang Sun; Leonard H Rome
Vault nanoparticles engineered with the protein transduction domain, TAT48, enhances cellular uptake.
Integrative biology : quantitative biosciences from nano to macro 2013;5(1):151-8.
2012: Upendra K Kar; Cheryl I Champion; Janina Jiang; Valerie A Kickhoefer; Kayvan R Niazi; Shahrooz Rabizadeh; Leonard H Rome; Sahar Salehi; Sherven Sharma; Minu Srivastava; Kathleen A Kelly
Vault nanocapsules as adjuvants favor cell-mediated over antibody-mediated immune responses following immunization of mice.
PloS one 2012;7(7):e38553.
2011: Muri Han; Valerie A Kickhoefer; Glen R Nemerow; Leonard H Rome
Targeted vault nanoparticles engineered with an endosomolytic peptide deliver biomolecules to the cytoplasm.
ACS nano 2011;5(8):6128-37.
2011: Daniel C Buehler; Daniel B Toso; Valerie A Kickhoefer; Z Hong Zhou; Leonard H Rome
Vaults engineered for hydrophobic drug delivery.
Small (Weinheim an der Bergstrasse, Germany) 2011;7(10):1432-9.
2011: Upendra K Kar; Minu K Srivastava; Asa Andersson; Felicita Baratelli; Min Huang; Valerie A Kickhoefer; Steven M Dubinett; Leonard H Rome; Sherven Sharma
Novel CCL21-vault nanocapsule intratumoral delivery inhibits lung cancer growth.
PloS one 2011;6(5):e18758.
2010: Jian Yang; Valerie A Kickhoefer; Benny C Ng; Ajaykumar Gopal; Laurent A Bentolila; Scott John; Sarah H Tolbert; Leonard H Rome
Vaults are dynamically unconstrained cytoplasmic nanoparticles capable of half vault exchange.
ACS nano 2010;4(12):7229-40.
2010: Yun Xia; Yamini Ramgopal; Hai Li; Lei Shang; Parisa Srinivas; Valerie A Kickhoefer; Leonard H Rome; Peter R Preiser; Freddy Boey; Hua Zhang; Subbu S Venkatraman
Immobilization of recombinant vault nanoparticles on solid substrates.
ACS nano 2010;4(3):1417-24.
2009: Lisa E Goldsmith; Melody Pupols; Valerie A Kickhoefer; Leonard H Rome; Harold G Monbouquette
Utilization of a protein "shuttle" to load vault nanocapsules with gold probes and proteins.
ACS nano 2009;3(10):3175-83.
2009: Reza Esfandiary; Valerie A Kickhoefer; Leonard H Rome; Sangeeta B Joshi; C Russell Middaugh
Structural stability of vault particles.
Journal of pharmaceutical sciences 2009;98(4):1376-86.
2009: Cheng-Yu Lai; Chris M Wiethoff; Valerie A Kickhoefer; Leonard H Rome; Glen R Nemerow
Vault nanoparticles containing an adenovirus-derived membrane lytic protein facilitate toxin and gene transfer.
ACS nano 2009;3(3):691-9.
2009: Valerie A Kickhoefer; Muri Han; Sujna Raval-Fernandes; Michael J Poderycki; Raymond J Moniz; Dana Vaccari; Mariena Silvestry; Phoebe L Stewart; Kathleen A Kelly; Leonard H Rome
Targeting vault nanoparticles to specific cell surface receptors.
ACS nano 2009;3(1):27-36.
2009: Cheryl I Champion; Valerie A Kickhoefer; Guangchao Liu; Raymond J Moniz; Amanda S Freed; Liisa L Bergmann; Dana Vaccari; Sujna Raval-Fernandes; Ann M Chan; Leonard H Rome; Kathleen A Kelly
A vault nanoparticle vaccine induces protective mucosal immunity.
PloS one 2009;4(4):e5409.
2007: Daniel H Anderson; Valerie A Kickhoefer; Stuart A Sievers; Leonard H Rome; David Eisenberg
Draft crystal structure of the vault shell at 9-A resolution.
PLoS biology 2007;5(11):e318.
2007: Catherine S Kaddis; Shirley H Lomeli; Sheng Yin; Beniam Berhane; Marcin I Apostol; Valerie A Kickhoefer; Leonard H Rome; Joseph A Loo
Sizing large proteins and protein complexes by electrospray ionization mass spectrometry and ion mobility.
Journal of the American Society for Mass Spectrometry 2007;18(7):1206-16.
2006: Michael J Poderycki; Valerie A Kickhoefer; Catherine S Kaddis; Sujna Raval-Fernandes; Erik Johansson; Jeffrey I Zink; Joseph A Loo; Leonard H Rome
The vault exterior shell is a dynamic structure that allows incorporation of vault-associated proteins into its interior.
Biochemistry 2006;45(39):12184-93.
2005: Sujna Raval-Fernandes; Valerie A Kickhoefer; Christina Kitchen; Leonard H Rome
Increased susceptibility of vault poly(ADP-ribose) polymerase-deficient mice to carcinogen-induced tumorigenesis.
Cancer research 2005;65(19):8846-52.
2005: Valerie A Kickhoefer; Yvette Garcia; Yeshi Mikyas; Erik Johansson; Jing C Zhou; Sujna Raval-Fernandes; Payam N Minoofar; Jeffrey I Zink; Bruce Dunn; Phoebe L Stewart; Leonard H Rome
Engineering of vault nanocapsules with enzymatic and fluorescent properties.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(12):4348-52.
2005: Michael J Poderycki; Leonard H Rome; Lea Harrington; Valerie A Kickhoefer
The p80 homology region of TEP1 is sufficient for its association with the telomerase and vault RNAs, and the vault particle.
Nucleic acids research 2005;33(3):893-902.
2004: Yeshi Mikyas; Miriam Makabi; Sujna Raval-Fernandes; Lea Harrington; Valerie A Kickhoefer; Leonard H Rome; Phoebe L Stewart
Cryoelectron microscopy imaging of recombinant and tissue derived vaults: localization of the MVP N termini and VPARP.
Journal of molecular biology 2004;344(1):91-105.
2004: Yie Liu; Bryan E Snow; Valerie A Kickhoefer; Natalie Erdmann; Wen Zhou; Andrew Wakeham; Marla Gomez; Leonard H Rome; Lea Harrington
Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo.
Molecular and cellular biology 2004;24(12):5314-23.
2004: Nil Emre; Sujna Raval-Fernandes; Valerie A Kickhoefer; Leonard H Rome
Analysis of MVP and VPARP promoters indicates a role for chromatin remodeling in the regulation of MVP.
Biochimica et biophysica acta 2004;1678(1):33-46.
2003: Valerie A Kickhoefer; Nil Emre; Andrew G Stephen; Michael J Poderycki; Leonard H Rome
Identification of conserved vault RNA expression elements and a non-expressed mouse vault RNA gene.
Gene 2003;309(2):65-70.
2002: Marieke H Mossink; Arend van Zon; Erna Fränzel-Luiten; Martijn Schoester; Valerie A Kickhoefer; George L Scheffer; Rik J Scheper; Pieter Sonneveld; Erik A C Wiemer
Disruption of the murine major vault protein (MVP/LRP) gene does not induce hypersensitivity to cytostatics.
Cancer research 2002;62(24):7298-304.
2002: Valerie A Kickhoefer; Michael J Poderycki; Edward Chan; Leonard H Rome
The La RNA-binding protein interacts with the vault RNA and is a vault-associated protein.
The Journal of biological chemistry 2002;277(43):41282-6.
2001: Andrew G Stephen; Sujna Raval-Fernandes; T Huynh; M Torres; Valerie A Kickhoefer; Leonard H Rome
Assembly of vault-like particles in insect cells expressing only the major vault protein.
The Journal of biological chemistry 2001;276(26):23217-20.
2001: AC Siva; Sujna Raval-Fernandes; Andrew G Stephen; M J LaFemina; Rik J Scheper; Valerie A Kickhoefer; Leonard H Rome
Up-regulation of vaults may be necessary but not sufficient for multidrug resistance.
International journal of cancer. Journal international du cancer 2001;92(2):195-202.
2001: Valerie A Kickhoefer; Y Liu; LB Kong; Bryan E Snow; Phoebe L Stewart; Lea Harrington; Leonard H Rome
The Telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle.
The Journal of cell biology 2001;152(1):157-64.
2000: Yie Liu; Bryan E Snow; M Prakash Hande; G Baerlocher; Valerie A Kickhoefer; D Yeung; Andrew Wakeham; Annick Itie; David Siderovski; PM Lansdorp; Murray O Robinson; Lea Harrington
Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo.
Molecular and cellular biology 2000;20(21):8178-84.
2000: LB Kong; AC Siva; Valerie A Kickhoefer; Leonard H Rome; Phoebe L Stewart
RNA location and modeling of a WD40 repeat domain within the vault.
RNA (New York, N.Y.) 2000;6(6):890-900.
2000: Anouk B Schroeijers; AC Siva; George L Scheffer; Mariska C de Jong; S C Bolick; Danny F Dukers; Jerry W Slootstra; Rob H Meloen; Erik A C Wiemer; Valerie A Kickhoefer; Leonard H Rome; Rik J Scheper
The Mr 193,000 vault protein is up-regulated in multidrug-resistant cancer cell lines.
Cancer research 2000;60(4):1104-10.
1999: Valerie A Kickhoefer; Andrew G Stephen; Lea Harrington; Murray O Robinson; Leonard H Rome
Vaults and telomerase share a common subunit, TEP1.
The Journal of biological chemistry 1999;274(46):32712-7.
1999: Valerie A Kickhoefer; AC Siva; Nancy Kedersha; Elisabeth M Inman; C Ruland; Michel Streuli; Leonard H Rome
The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase.
The Journal of cell biology 1999;146(5):917-28.
1999: Sujna Raval-Fernandes; Valerie A Kickhoefer; Leonard H Rome
Cloning of a cDNA encoding a sequence-specific single-stranded-DNA-binding protein from Rattus norvegicus.
Gene 1999;237(1):201-7.
1998: Valerie A Kickhoefer; K S Rajavel; George L Scheffer; W S Dalton; R J Scheper; Leonard H Rome
Vaults are up-regulated in multidrug-resistant cancer cell lines.
The Journal of biological chemistry 1998;273(15):8971-4.
1996: Valerie A Kickhoefer; Sanjay Vasu; Leonard H Rome
Vaults are the answer, what is the question?
Trends in cell biology 1996;6(5):174-8.
1994: Valerie A Kickhoefer; Leonard H Rome
The sequence of a cDNA encoding the major vault protein from Rattus norvegicus.
Gene 1994;151(1-2):257-60.
1994: Adrian Vilalta; Valerie A Kickhoefer; Leonard H Rome; Deborah L Johnson
The rat vault RNA gene contains a unique RNA polymerase III promoter composed of both external and internal elements that function synergistically.
The Journal of biological chemistry 1994;269(47):29752-9.
1993: Valerie A Kickhoefer; Robert Searles; Nancy Kedersha; M E Garber; Deborah L Johnson; Leonard H Rome
Vault ribonucleoprotein particles from rat and bullfrog contain a related small RNA that is transcribed by RNA polymerase III.
The Journal of biological chemistry 1993;268(11):7868-73.