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Margaret Kielian

Research Profile

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TOP 3
Frederic Vigant; Markus R Wenk; Mike C Wolf; Tatyana Yun; Dong Zhang; Hector C Aguilar; Zeynep Akyol Ataman; Ashley Banyard; Hubert Buczkowski; Miguel A R B Castanho; Sunwen Chou; Alexander Freiberg; Axel Hollmann; Terry L Juelich; Michael E Jung; Margaret Kielian; Jihye Lee; David Meriwether; Srinivasa Reddy; Lindsey R Robinson; Gleyder Roman-Sosa; Nuno C Santos; Matthias Selke; Guanghou Shui; Jennifer K Smith; Lukas B Tanner; Benhur Lee
A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion.
Whitney Fields; Margaret Kielian
A key interaction between the alphavirus envelope proteins responsible for initial dimer dissociation during fusion.
Catherine Y Liu; Margaret Kielian
Identification of a specific region in the e1 fusion protein involved in zinc inhibition of semliki forest virus fusion.

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All Publications

2013: Frederic Vigant; Markus R Wenk; Mike C Wolf; Tatyana Yun; Dong Zhang; Hector C Aguilar; Zeynep Akyol Ataman; Ashley Banyard; Hubert Buczkowski; Miguel A R B Castanho; Sunwen Chou; Alexander Freiberg; Axel Hollmann; Terry L Juelich; Michael E Jung; Margaret Kielian; Jihye Lee; David Meriwether; Srinivasa Reddy; Lindsey R Robinson; Gleyder Roman-Sosa; Nuno C Santos; Matthias Selke; Guanghou Shui; Jennifer K Smith; Lukas B Tanner; Benhur Lee
A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion.
PLoS pathogens 2013;9(4):e1003297.
2013: Whitney Fields; Margaret Kielian
A key interaction between the alphavirus envelope proteins responsible for initial dimer dissociation during fusion.
Journal of virology 2013;87(7):3774-81.
2012: Catherine Y Liu; Margaret Kielian
Identification of a specific region in the e1 fusion protein involved in zinc inhibition of semliki forest virus fusion.
Journal of virology 2012;86(7):3588-94.
2011: Gleyder Roman-Sosa; Margaret Kielian
The interaction of alphavirus E1 protein with exogenous domain III defines stages in virus-membrane fusion.
Journal of virology 2011;85(23):12271-9.
2011: Katie M Stiles; Margaret Kielian
Alphavirus entry: NRAMP leads the way.
Cell host & microbe 2011;10(2):92-3.
2011: Yan Zheng; Zhao-ling Qin; Claudia Sánchez-San Martín; Margaret Kielian
The domain I-domain III linker plays an important role in the fusogenic conformational change of the alphavirus membrane fusion protein.
Journal of virology 2011;85(13):6334-42.
2010: Margaret Kielian
Structural biology: An alphavirus puzzle solved.
Nature 2010;468(7324):645-6.
2010: Catherine Y Liu; Christen Besanceney; Yifan Song; Margaret Kielian
Pseudorevertants of a Semliki forest virus fusion-blocking mutation reveal a critical interchain interaction in the core trimer.
Journal of virology 2010;84(22):11624-33.
2010: Maofu Liao; Claudia Sánchez-San Martín; Aihua Zheng; Margaret Kielian
In vitro reconstitution reveals key intermediate states of trimer formation by the dengue virus membrane fusion protein.
Journal of virology 2010;84(11):5730-40.
2010: Aihua Zheng; Mahadevaiah Umashankar; Margaret Kielian
In vitro and in vivo studies identify important features of dengue virus pr-E protein interactions.
PLoS pathogens 2010;6(10):e1001157.
2009: Claudia Sánchez-San Martín; Catherine Y Liu; Margaret Kielian
Dealing with low pH: entry and exit of alphaviruses and flaviviruses.
Trends in microbiology 2009;17(11):514-21.
2009: Catherine Y Liu; Margaret Kielian
E1 mutants identify a critical region in the trimer interface of the Semliki forest virus fusion protein.
Journal of virology 2009;83(21):11298-306.
2009: Zhao-Ling Qin; Yan Zheng; Margaret Kielian
Role of conserved histidine residues in the low-pH dependence of the Semliki Forest virus fusion protein.
Journal of virology 2009;83(9):4670-7.
2008: Claudia Sánchez-San Martín; Hernando Sosa; Margaret Kielian
A stable prefusion intermediate of the alphavirus fusion protein reveals critical features of class II membrane fusion.
Cell host & microbe 2008;4(6):600-8.
2008: M Umashankar; Claudia Sánchez-San Martín; Maofu Liao; Brigid Reilly; Alice Guo; Gwen Taylor; Margaret Kielian
Differential cholesterol binding by class II fusion proteins determines membrane fusion properties.
Journal of virology 2008;82(18):9245-53.
2007: Gwen M Taylor; Phyllis I Hanson; Margaret Kielian
Ubiquitin depletion and dominant-negative VPS4 inhibit rhabdovirus budding without affecting alphavirus budding.
Journal of virology 2007;81(24):13631-9.
2007: Ruben M Markosyan; Margaret Kielian; Fredric S Cohen
Fusion induced by a class II viral fusion protein, semliki forest virus E1, is dependent on the voltage of the target cell.
Journal of virology 2007;81(20):11218-25.
2006: Maofu Liao; Margaret Kielian
Functions of the stem region of the Semliki Forest virus fusion protein during virus fusion and assembly.
Journal of virology 2006;80(22):11362-9.
2006: Maofu Liao; Margaret Kielian
Site-directed antibodies against the stem region reveal low pH-induced conformational changes of the Semliki Forest virus fusion protein.
Journal of virology 2006;80(19):9599-607.
2006: Chantal Chanel-Vos; Margaret Kielian
Second-site revertants of a Semliki Forest virus fusion-block mutation reveal the dynamics of a class II membrane fusion protein.
Journal of virology 2006;80(12):6115-22.
2006: Margaret Kielian
Class II virus membrane fusion proteins.
Virology 2006;344(1):38-47.
2006: Margaret Kielian; Félix A Rey
Virus membrane-fusion proteins: more than one way to make a hairpin.
Nature reviews. Microbiology 2006;4(1):67-76.
2005: Maofu Liao; Margaret Kielian
Domain III from class II fusion proteins functions as a dominant-negative inhibitor of virus membrane fusion.
The Journal of cell biology 2005;171(1):111-20.
2005: Xinyong Zhang; Margaret Kielian
An interaction site of the envelope proteins of Semliki Forest virus that is preserved after proteolytic activation.
Virology 2005;337(2):344-52.
2005: Maofu Liao; Margaret Kielian
The conserved glycine residues in the transmembrane domain of the Semliki Forest virus fusion protein are not required for assembly and fusion.
Virology 2005;332(1):430-7.
2004: Chantal Chanel-Vos; Margaret Kielian
A conserved histidine in the ij loop of the Semliki Forest virus E1 protein plays an important role in membrane fusion.
Journal of virology 2004;78(24):13543-52.
2004: Xinyong Zhang; Margaret Kielian
Mutations that promote furin-independent growth of Semliki Forest virus affect p62-E1 interactions and membrane fusion.
Virology 2004;327(2):287-96.
2004: Don L Gibbons; Brigid Reilly; Anna Ahn; Marie-Christine Vaney; Armelle Vigouroux; Félix A Rey; Margaret Kielian
Purification and crystallization reveal two types of interactions of the fusion protein homotrimer of Semliki Forest virus.
Journal of virology 2004;78(7):3514-23.
2004: Don L Gibbons; Anna Ahn; Maofu Liao; Lena Hammar; R Holland Cheng; Margaret Kielian
Multistep regulation of membrane insertion of the fusion peptide of Semliki Forest virus.
Journal of virology 2004;78(7):3312-8.
2004: Don L Gibbons; Marie-Christine Vaney; Alain Roussel; Armelle Vigouroux; Brigid Reilly; Jean Lepault; Margaret Kielian; Félix A Rey
Conformational change and protein-protein interactions of the fusion protein of Semliki Forest virus.
Nature 2004;427(6972):320-5.
2003: Don L Gibbons; Inge Erk; Brigid Reilly; Jorge Navaza; Margaret Kielian; Félix A Rey; Jean Lepault
Visualization of the target-membrane-inserted fusion protein of Semliki Forest virus by combined electron microscopy and crystallography.
Cell 2003;114(5):573-83.
2003: Xinyong Zhang; Martin Fugere; Robert Day; Margaret Kielian
Furin processing and proteolytic activation of Semliki Forest virus.
Journal of virology 2003;77(5):2981-9.
2002: Prodyot Chatterjee; Christina H Eng; Margaret Kielian
Novel mutations that control the sphingolipid and cholesterol dependence of the Semliki Forest virus fusion protein.
Journal of virology 2002;76(24):12712-22.
2002: Andrey Samsonov; Prodyot Chatterjee; Vladimir Razinkov; Christina H Eng; Margaret Kielian; Fredric S Cohen
Effects of membrane potential and sphingolipid structures on fusion of Semliki Forest virus.
Journal of virology 2002;76(24):12691-702.
2002: Anna Ahn; Don L Gibbons; Margaret Kielian
The fusion peptide of Semliki Forest virus associates with sterol-rich membrane domains.
Journal of virology 2002;76(7):3267-75.
2002: Margaret Kielian
Structural surprises from the flaviviruses and alphaviruses.
Molecular cell 2002;9(3):454-6.
2002: Don L Gibbons; Margaret Kielian
Molecular dissection of the Semliki Forest virus homotrimer reveals two functionally distinct regions of the fusion protein.
Journal of virology 2002;76(3):1194-205.
2001: YE Lu; Christina H Eng; S G Shome; Margaret Kielian
In vivo generation and characterization of a soluble form of the Semliki forest virus fusion protein.
Journal of virology 2001;75(17):8329-39.
2001: S G Shome; Margaret Kielian
Differential roles of two conserved glycine residues in the fusion peptide of Semliki Forest virus.
Virology 2001;279(1):146-60.
2000: Don L Gibbons; Anna Ahn; Prodyot Chatterjee; Margaret Kielian
Formation and characterization of the trimeric form of the fusion protein of Semliki Forest Virus.
Journal of virology 2000;74(17):7772-80.
2000: YE Lu; Margaret Kielian
Semliki forest virus budding: assay, mechanisms, and cholesterol requirement.
Journal of virology 2000;74(17):7708-19.
2000: Prodyot Chatterjee; M Vashishtha; Margaret Kielian
Biochemical consequences of a mutation that controls the cholesterol dependence of Semliki Forest virus fusion.
Journal of virology 2000;74(4):1623-31.
2000: Margaret Kielian; Prodyot Chatterjee; Don L Gibbons; YE Lu
Specific roles for lipids in virus fusion and exit. Examples from the alphaviruses.
Sub-cellular biochemistry 2000;34():409-55.
1999: Anna Ahn; M R Klimjack; Prodyot Chatterjee; Margaret Kielian
An epitope of the Semliki Forest virus fusion protein exposed during virus-membrane fusion.
Journal of virology 1999;73(12):10029-39.
1999: Anna Ahn; R J Schoepp; D Sternberg; Margaret Kielian
Growth and stability of a cholesterol-independent Semliki Forest virus mutant in mosquitoes.
Virology 1999;262(2):452-6.
1999: YE Lu; T Cassese; Margaret Kielian
The cholesterol requirement for sindbis virus entry and exit and characterization of a spike protein region involved in cholesterol dependence.
Journal of virology 1999;73(5):4272-8.
1998: S Glomb-Reinmund; Margaret Kielian
The role of low pH and disulfide shuffling in the entry and fusion of Semliki Forest virus and Sindbis virus.
Virology 1998;248(2):372-81.
1998: S Glomb-Reinmund; Margaret Kielian
fus-1, a pH shift mutant of Semliki Forest virus, acts by altering spike subunit interactions via a mutation in the E2 subunit.
Journal of virology 1998;72(5):4281-7.
1998: M Vashishtha; T Phalen; M T Marquardt; J S Ryu; A C Ng; Margaret Kielian
A single point mutation controls the cholesterol dependence of Semliki Forest virus entry and exit.
The Journal of cell biology 1998;140(1):91-9.
1997: M M Rolls; M T Marquardt; Margaret Kielian; Carolyn E Machamer
Cholesterol-independent targeting of Golgi membrane proteins in insect cells.
Molecular biology of the cell 1997;8(11):2111-8.
1997: N L Jacobs; B Andemariam; K W Underwood; K Panchalingam; D Sternberg; Margaret Kielian; Laura Liscum
Analysis of a Chinese hamster ovary cell mutant with defective mobilization of cholesterol from the plasma membrane to the endoplasmic reticulum.
Journal of lipid research 1997;38(10):1973-87.
1996: M T Marquardt; Margaret Kielian
Cholesterol-depleted cells that are relatively permissive for Semliki Forest virus infection.
Virology 1996;224(1):198-205.
1996: Margaret Kielian; M R Klimjack; S Ghosh; Wayne Duffus
Mechanisms of mutations inhibiting fusion and infection by Semliki Forest virus.
The Journal of cell biology 1996;134(4):863-72.
1996: J L Martys; C Wjasow; D M Gangi; Margaret Kielian; Timothy E McGraw; Jonathan M Backer
Wortmannin-sensitive trafficking pathways in Chinese hamster ovary cells. Differential effects on endocytosis and lysosomal sorting.
The Journal of biological chemistry 1996;271(18):10953-62.
1995: Wayne Duffus; P Levy-Mintz; M R Klimjack; Margaret Kielian
Mutations in the putative fusion peptide of Semliki Forest virus affect spike protein oligomerization and virus assembly.
Journal of virology 1995;69(4):2471-9.
1995: Margaret Kielian
Membrane fusion and the alphavirus life cycle.
Advances in virus research 1995;45():113-51.
1994: M R Klimjack; S Jeffrey; Margaret Kielian
Membrane and protein interactions of a soluble form of the Semliki Forest virus fusion protein.
Journal of virology 1994;68(11):6940-6.
1993: Jessica Justman; M R Klimjack; Margaret Kielian
Role of spike protein conformational changes in fusion of Semliki Forest virus.
Journal of virology 1993;67(12):7597-607.
1993: M T Marquardt; T Phalen; Margaret Kielian
Cholesterol is required in the exit pathway of Semliki Forest virus.
The Journal of cell biology 1993;123(1):57-65.
1991: P Levy-Mintz; Margaret Kielian
Mutagenesis of the putative fusion domain of the Semliki Forest virus spike protein.
Journal of virology 1991;65(8):4292-300.
1991: S K Jain; S DeCandido; Margaret Kielian
Processing of the p62 envelope precursor protein of Semliki Forest virus.
The Journal of biological chemistry 1991;266(9):5756-61.
1991: T Phalen; Margaret Kielian
Cholesterol is required for infection by Semliki Forest virus.
The Journal of cell biology 1991;112(4):615-23.
1990: Margaret Kielian; S Jungerwirth; K U Sayad; S DeCandido
Biosynthesis, maturation, and acid activation of the Semliki Forest virus fusion protein.
Journal of virology 1990;64(10):4614-24.
1990: Margaret Kielian; S Jungerwirth
Mechanisms of enveloped virus entry into cells.
Molecular biology & medicine 1990;7(1):17-31.
1989: S Schmid; R Fuchs; Margaret Kielian; Ari Helenius; Ira Mellman
Acidification of endosome subpopulations in wild-type Chinese hamster ovary cells and temperature-sensitive acidification-defective mutants.
The Journal of cell biology 1989;108(4):1291-300.
1986: Margaret Kielian; M Marsh; ari Helenius
Kinetics of endosome acidification detected by mutant and wild-type Semliki Forest virus.
The EMBO journal 1986;5(12):3103-9.
1986: Margaret Kielian
Assay of phagosome-lysosome fusion.
Methods in enzymology 1986;132():257-67.
1985: Margaret Kielian; ari Helenius
pH-induced alterations in the fusogenic spike protein of Semliki Forest virus.
The Journal of cell biology 1985;101(6):2284-91.
1985: ari Helenius; Margaret Kielian; J Wellsteed; I Mellman; G Rudnick
Effects of monovalent cations on Semliki Forest virus entry into BHK-21 cells.
The Journal of biological chemistry 1985;260(9):5691-7.
1984: M Marsh; Margaret Kielian; ari Helenius
Semliki forest virus entry and the endocytic pathway.
Biochemical Society transactions 1984;12(6):981-3.
1984: Margaret Kielian; ari Helenius
Role of cholesterol in fusion of Semliki Forest virus with membranes.
Journal of virology 1984;52(1):281-3.
1984: Margaret Kielian; S Keränen; L Kääriäinen; ari Helenius
Membrane fusion mutants of Semliki Forest virus.
The Journal of cell biology 1984;98(1):139-45.
1983: J White; Margaret Kielian; ari Helenius
Membrane fusion proteins of enveloped animal viruses.
Quarterly reviews of biophysics 1983;16(2):151-95.
1982: Margaret Kielian; Z A Cohn
Intralysosomal accumulation of polyanions. II. Polyanion internalization and its influence on lysosomal pH and membrane fluidity.
The Journal of cell biology 1982;93(3):875-82.
1982: Margaret Kielian; R M Steinman; Z A Cohn
Intralysosomal accumulation of polyanions. I. Fusion of pinocytic and phagocytic vacuoles with secondary lysosomes.
The Journal of cell biology 1982;93(3):866-74.
1981: Margaret Kielian; Z A Cohn
Phorbol myristate acetate stimulates phagosome-lysosome fusion in mouse macrophages.
The Journal of experimental medicine 1981;154(1):101-11.
1981: Margaret Kielian; Z A Cohn
Modulation of phagosome-lysosome fusion in mouse macrophages.
The Journal of experimental medicine 1981;153(4):1015-20.
1980: Margaret Kielian; Z A Cohn
Phagosome-lysosome fusion. Characterization of intracellular membrane fusion in mouse macrophages.
The Journal of cell biology 1980;85(3):754-65.
1977: Margaret Kielian; C F Beyer; W E Bowers
Cell-cell interactions in blast transformation of rat lymphocytes by neuraminidase and galactose oxidase.
Experimental cell research 1977;109(1):211-21.