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Cay Kielty

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Chemicals & Drugs

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Marfan's Syndrome

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TOP 3
Stephen G Ball; Adrian Shuttleworth; Cay M Kielty
Inhibition of platelet-derived growth factor receptor signaling regulates Oct4 and Nanog expression, cell shape, and mesenchymal stem cell potency.
Stuart A Cain; Clair Baldock; Andrew K Baldwin; Amanda McGovern; Cay M Kielty
Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.
Nicola Beecher; Richard Berry; Thomas A Jowitt; Richard A Kammerer; Cay M Kielty; Alan M Roseman; C Adrian Shuttleworth; Helen Troilo; Clair Baldock
Collagen VI, conformation of A-domain arrays and microfibril architecture.

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2012: Stephen G Ball; Adrian Shuttleworth; Cay M Kielty
Inhibition of platelet-derived growth factor receptor signaling regulates Oct4 and Nanog expression, cell shape, and mesenchymal stem cell potency.
Stem cells (Dayton, Ohio) 2012;30(3):548-60.
2012: Stuart A Cain; Clair Baldock; Andrew K Baldwin; Amanda McGovern; Cay M Kielty
Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.
PloS one 2012;7(11):e48634.
2011: Nicola Beecher; Richard Berry; Thomas A Jowitt; Richard A Kammerer; Cay M Kielty; Alan M Roseman; C Adrian Shuttleworth; Helen Troilo; Clair Baldock
Collagen VI, conformation of A-domain arrays and microfibril architecture.
The Journal of biological chemistry 2011;286(46):40266-75.
2011: Jemima L Whyte; Stephen G Ball; C Adrian Shuttleworth; Keith Brennan; Cay M Kielty
Density of human bone marrow stromal cells regulates commitment to vascular lineages.
Stem cell research 2011;6(3):238-50.
2011: Jennifer Veevers-Lowe; Stephen G Ball; Adrian Shuttleworth; Cay M Kielty
Mesenchymal stem cell migration is regulated by fibronectin through α5β1-integrin-mediated activation of PDGFR-β and potentiation of growth factor signals.
Journal of cell science 2011;124(Pt 8):1288-300.
2010: Teresa Massam-Wu; Maybo Chiu; Rawshan Choudhury; Shazia S Chaudhry; Andrew K Baldwin; Amanda McGovern; Clair Baldock; C Adrian Shuttleworth; Cay M Kielty
Assembly of fibrillin microfibrils governs extracellular deposition of latent TGF beta.
Journal of cell science 2010;123(Pt 17):3006-18.
2010: Richard P O Jones; Caroline Ridley; Thomas A Jowitt; Ming-Chuan Wang; Marjorie Howard; Nicoletta Bobola; Tao Wang; Paul N Bishop; Cay M Kielty; Clair Baldock; Andrew J Lotery; Dorothy Trump
Structural effects of fibulin 5 missense mutations associated with age-related macular degeneration and cutis laxa.
Investigative ophthalmology & visual science 2010;51(5):2356-62.
2010: Stephen G Ball; Christopher Bayley; C Adrian Shuttleworth; Cay M Kielty
Neuropilin-1 regulates platelet-derived growth factor receptor signalling in mesenchymal stem cells.
The Biochemical journal 2010;427(1):29-40.
2010: Stephen G Ball; C Adrian Shuttleworth; Cay M Kielty
Platelet-derived growth factor receptors regulate mesenchymal stem cell fate: implications for neovascularization.
Expert opinion on biological therapy 2010;10(1):57-71.
2009: Stuart A Cain; Amanda McGovern; Elaine Small; Lyle J Ward; Clair Baldock; Adrian Shuttleworth; Cay M Kielty
Defining elastic fiber interactions by molecular fishing: an affinity purification and mass spectrometry approach.
Molecular & cellular proteomics : MCP 2009;8(12):2715-32.
2009: Richard P O Jones; Ming-Chuan Wang; Thomas A Jowitt; Caroline Ridley; Kieran T Mellody; Marjorie Howard; Tao Wang; Paul N Bishop; Andrew J Lotery; Cay M Kielty; Clair Baldock; Dorothy Trump
Fibulin 5 forms a compact dimer in physiological solutions.
The Journal of biological chemistry 2009;284(38):25938-43.
2009: Rawshan Choudhury; Amanda McGovern; Caroline Ridley; Stuart A Cain; Andrew Baldwin; Ming-Chuan Wang; Chun Guo; Aleksandr Mironov; Zoe Drymoussi; Dorothy Trump; Adrian Shuttleworth; Clair Baldock; Cay M Kielty
Differential regulation of elastic fiber formation by fibulin-4 and -5.
The Journal of biological chemistry 2009;284(36):24553-67.
2009: Michael J Sherratt; Roger S Meadows; HK Graham; Cay M Kielty; David F Holmes
ECM macromolecules: rotary shadowing and transmission electron microscopy.
Methods in molecular biology (Clifton, N.J.) 2009;522():175-81.
2009: Nigel W Hodson; Cay M Kielty; Michael J Sherratt
ECM macromolecules: height-mapping and nano-mechanics using atomic force microscopy.
Methods in molecular biology (Clifton, N.J.) 2009;522():123-41.
2009: Michael J Sherratt; HK Graham; Cay M Kielty; David F Holmes
Mass-mapping of ECM macromolecules by scanning transmission electron microscopy.
Methods in molecular biology (Clifton, N.J.) 2009;522():151-61.
2008: Stuart A Cain; Andrew K Baldwin; Yashithra Mahalingam; Bertrand Raynal; Thomas A Jowitt; C Adrian Shuttleworth; John R Couchman; Cay M Kielty
Heparan sulfate regulates fibrillin-1 N- and C-terminal interactions.
The Journal of biological chemistry 2008;283(40):27017-27.
2008: Rachel Kinsey; Matthew R Williamson; Shazia Chaudhry; Kieran T Mellody; Amanda McGovern; Seiichiro Takahashi; C Adrian Shuttleworth; Cay M Kielty
Fibrillin-1 microfibril deposition is dependent on fibronectin assembly.
Journal of cell science 2008;121(Pt 16):2696-704.
2008: Stuart A Cain; Bertrand Raynal; Nigel Hodson; Adrian Shuttleworth; Cay M Kielty
Biomolecular analysis of elastic fibre molecules.
Methods (San Diego, Calif.) 2008;45(1):42-52.
2008: Anastassi T Halka; Neill J Turner; Andrew Carter; Jonathan Ghosh; Michael O Murphy; John P Kirton; Cay M Kielty; Michael G Walker
The effects of stretch on vascular smooth muscle cell phenotype in vitro.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2008;17(2):98-102.
2007: Matthew R Williamson; Adrian Shuttleworth; Ann E Canfield; Richard Black; Cay M Kielty
The role of endothelial cell attachment to elastic fibre molecules in the enhancement of monolayer formation and retention, and the inhibition of smooth muscle cell recruitment.
Biomaterials 2007;28(35):5307-18.
2007: Stephen G Ball; C Adrian Shuttleworth; Cay M Kielty
Mesenchymal stem cells and neovascularization: role of platelet-derived growth factor receptors.
Journal of cellular and molecular medicine 2007;11(5):1012-30.
2007: Cay M Kielty; Simon Stephan; Michael J Sherratt; Matthew Williamson; C Adrian Shuttleworth
Applying elastic fibre biology in vascular tissue engineering.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2007;362(1484):1293-312.
2007: Amanda Lomas; Kieran T Mellody; Lyle J Freeman; Daniel V Bax; C Adrian Shuttleworth; Cay M Kielty
Fibulin-5 binds human smooth-muscle cells through alpha5beta1 and alpha4beta1 integrins, but does not support receptor activation.
The Biochemical journal 2007;405(3):417-28.
2007: Stephen G Ball; C Adrian Shuttleworth; Cay M Kielty
Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.
The Journal of cell biology 2007;177(3):489-500.
2007: Daniel V Bax; Yashithra Mahalingam; Stuart A Cain; Kieran T Mellody; Lyle Freeman; Kerri Younger; C Adrian Shuttleworth; Martin J Humphries; John R Couchman; Cay M Kielty
Cell adhesion to fibrillin-1: identification of an Arg-Gly-Asp-dependent synergy region and a heparin-binding site that regulates focal adhesion formation.
Journal of cell science 2007;120(Pt 8):1383-92.
2007: Michael J Sherratt; Clair Baldock; Amanda Morgan; Cay M Kielty
The morphology of adsorbed extracellular matrix assemblies is critically dependent on solution calcium concentration.
Matrix biology : journal of the International Society for Matrix Biology 2007;26(3):156-66.
2007: Shazia S Chaudhry; Stuart A Cain; Amanda Morgan; Sarah L Dallas; C Adrian Shuttleworth; Cay M Kielty
Fibrillin-1 regulates the bioavailability of TGFbeta1.
The Journal of cell biology 2007;176(3):355-67.
2007: Stephen G Ball; C Adrian Shuttleworth; Cay M Kielty
Platelet-derived growth factor receptor-alpha is a key determinant of smooth muscle alpha-actin filaments in bone marrow-derived mesenchymal stem cells.
The international journal of biochemistry & cell biology 2007;39(2):379-91.
2006: Kieran T Mellody; Lyle J Freeman; Clair Baldock; Thomas A Jowitt; Veronique Siegler; Bertrand D E Raynal; Stuart A Cain; Tim J Wess; C Adrian Shuttleworth; Cay M Kielty
Marfan syndrome-causing mutations in fibrillin-1 result in gross morphological alterations and highlight the structural importance of the second hybrid domain.
The Journal of biological chemistry 2006;281(42):31854-62.
2006: Simon Stephan; Stephen G Ball; Matthew Williamson; Daniel V Bax; Amanda Lomas; C Adrian Shuttleworth; Cay M Kielty
Cell-matrix biology in vascular tissue engineering.
Journal of anatomy 2006;209(4):495-502.
2006: Neill J Turner; Michael O Murphy; Cay M Kielty; C Adrian Shuttleworth; Richard Black; Martin J Humphries; Michael G Walker; Ann E Canfield
Alpha2(VIII) collagen substrata enhance endothelial cell retention under acute shear stress flow via an alpha2beta1 integrin-dependent mechanism: an in vitro and in vivo study.
Circulation 2006;114(8):820-9.
2006: Clair Baldock; Veronique Siegler; Daniel V Bax; Stuart A Cain; Kieran T Mellody; Andrew Marson; J Louise Haston; Richard Berry; Ming-Chuan Wang; J Günter Grossmann; Manfred Roessle; Cay M Kielty; Tim J Wess
Nanostructure of fibrillin-1 reveals compact conformation of EGF arrays and mechanism for extensibility.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(32):11922-7.
2006: Matthew R Williamson; Richard Black; Cay M Kielty
PCL-PU composite vascular scaffold production for vascular tissue engineering: attachment, proliferation and bioactivity of human vascular endothelial cells.
Biomaterials 2006;27(19):3608-16.
2006: Michael O Murphy; Jonathan Ghosh; Anastassi T Halka; Andrew Carter; Neill J Turner; Mark W J Ferguson; Cay M Kielty; Michael G Walker
In vivo attenuation of myointimal hyperplasia using transforming growth factor-beta3 in an interposition graft model.
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists 2006;13(3):389-99.
2006: Cay M Kielty
Elastic fibres in health and disease.
Expert reviews in molecular medicine 2006;8(19):1-23.
2006: Jonathan Ghosh; Mohamed S Baguneid; Nadeem Khwaja; Michael O Murphy; Neill Turner; Anastassi T Halka; Mark W J Ferguson; Cay M Kielty; Michael G Walker
Reduction of myointimal hyperplasia after arterial anastomosis by local injection of transforming growth factor beta3.
Journal of vascular surgery 2006;43(1):142-9.
2006: Stuart A Cain; Amanda Morgan; Michael J Sherratt; Stephen G Ball; C Adrian Shuttleworth; Cay M Kielty
Proteomic analysis of fibrillin-rich microfibrils.
Proteomics 2006;6(1):111-22.
2005: Michael J Sherratt; Daniel V Bax; Shazia S Chaudhry; Nigel Hodson; Jian R Lu; Priya Saravanapavan; Cay M Kielty
Substrate chemistry influences the morphology and biological function of adsorbed extracellular matrix assemblies.
Biomaterials 2005;26(34):7192-206.
2005: Stuart A Cain; Clair Baldock; John Gallagher; Amanda Morgan; Daniel V Bax; Anthony S Weiss; C Adrian Shuttleworth; Cay M Kielty
Fibrillin-1 interactions with heparin. Implications for microfibril and elastic fiber assembly.
The Journal of biological chemistry 2005;280(34):30526-37.
2005: Adam W Clarke; Steven G Wise; Stuart A Cain; Cay M Kielty; Anthony S Weiss
Coacervation is promoted by molecular interactions between the PF2 segment of fibrillin-1 and the domain 4 region of tropoelastin.
Biochemistry 2005;44(30):10271-81.
2005: Lyle J Freeman; Amanda Lomas; Nigel Hodson; Michael J Sherratt; Kieran T Mellody; Anthony S Weiss; Adrian Shuttleworth; Cay M Kielty
Fibulin-5 interacts with fibrillin-1 molecules and microfibrils.
The Biochemical journal 2005;388(Pt 1):1-5.
2005: Sarah L Dallas; Pitchumani Sivakumar; C J P Jones; Qian Chen; Donna M Peters; Deane F Mosher; Martin J Humphries; Cay M Kielty
Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1.
The Journal of biological chemistry 2005;280(19):18871-80.
2005: Andrew Marson; Matthew J Rock; Stuart A Cain; Lyle J Freeman; Amanda Morgan; Kieran T Mellody; C Adrian Shuttleworth; Clair Baldock; Cay M Kielty
Homotypic fibrillin-1 interactions in microfibril assembly.
The Journal of biological chemistry 2005;280(6):5013-21.
2005: Cay M Kielty; Michael J Sherratt; Andrew Marson; Clair Baldock
Fibrillin microfibrils.
Advances in protein chemistry 2005;70():405-36.
2005: Jonathan Ghosh; Michael O Murphy; Neill Turner; Nadeem Khwaja; Anastassi T Halka; Cay M Kielty; Michael G Walker
The role of transforming growth factor beta1 in the vascular system.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2005;14(1):28-36.
2004: Neill J Turner; Cay M Kielty; Michael G Walker; Ann E Canfield
A novel hyaluronan-based biomaterial (Hyaff-11) as a scaffold for endothelial cells in tissue engineered vascular grafts.
Biomaterials 2004;25(28):5955-64.
2004: Matthew J Rock; Stuart A Cain; Lyle J Freeman; Amanda Morgan; Kieran T Mellody; Andrew Marson; C Adrian Shuttleworth; Anthony S Weiss; Cay M Kielty
Molecular basis of elastic fiber formation. Critical interactions and a tropoelastin-fibrillin-1 cross-link.
The Journal of biological chemistry 2004;279(22):23748-58.
2004: Simon Stephan; Michael J Sherratt; Nigel Hodson; C Adrian Shuttleworth; Cay M Kielty
Expression and supramolecular assembly of recombinant alpha1(viii) and alpha2(viii) collagen homotrimers.
The Journal of biological chemistry 2004;279(20):21469-77.
2004: Michael J Sherratt; David F Holmes; C Adrian Shuttleworth; Cay M Kielty
Substrate-dependent morphology of supramolecular assemblies: fibrillin and type-VI collagen microfibrils.
Biophysical journal 2004;86(5):3211-22.
2004: Stephen G Ball; Adrian Shuttleworth; Cay M Kielty
Direct cell contact influences bone marrow mesenchymal stem cell fate.
The international journal of biochemistry & cell biology 2004;36(4):714-27.
2003: J Louise Haston; Soren B Engelsen; Manfred Roessle; John Clarkson; Ewan W Blanch; Clair Baldock; Cay M Kielty; Tim J Wess
Raman microscopy and X-ray diffraction, a combined study of fibrillin-rich microfibrillar elasticity.
The Journal of biological chemistry 2003;278(42):41189-97.
2003: Michael J Sherratt; Clair Baldock; J Louise Haston; David F Holmes; C J P Jones; C Adrian Shuttleworth; Tim J Wess; Cay M Kielty
Fibrillin microfibrils are stiff reinforcing fibres in compliant tissues.
Journal of molecular biology 2003;332(1):183-93.
2003: Daniel V Bax; Sarah E Bernard; Amanda Lomas; Amanda Morgan; Jon Humphries; C Adrian Shuttleworth; Martin J Humphries; Cay M Kielty
Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins.
The Journal of biological chemistry 2003;278(36):34605-16.
2003: Julia Buján; María J Gimeno; Jose A Jiménez; Cay M Kielty; Robert P Mecham; Juan M Bellón
Expression of elastic components in healthy and varicose veins.
World journal of surgery 2003;27(8):901-5.
2003: Clair Baldock; Michael J Sherratt; C Adrian Shuttleworth; Cay M Kielty
The supramolecular organization of collagen VI microfibrils.
Journal of molecular biology 2003;330(2):297-307.
2003: Stephen Ball; Jordi Bella; Cay M Kielty; Adrian Shuttleworth
Structural basis of type VI collagen dimer formation.
The Journal of biological chemistry 2003;278(17):15326-32.
2003: Ibrahima Diagne; Susan M Hall; Shigetoyo Kogaki; Cay M Kielty; Sheila G Haworth
Paxillin-associated focal adhesion involvement in perinatal pulmonary arterial remodelling.
Matrix biology : journal of the International Society for Matrix Biology 2003;22(2):193-205.
2002: M Helen Rajpar; Martin J Koch; Robin M Davies; Kieran T Mellody; Cay M Kielty; Michael J Dixon
Mutation of the signal peptide region of the bicistronic gene DSPP affects translocation to the endoplasmic reticulum and results in defective dentine biomineralization.
Human molecular genetics 2002;11(21):2559-65.
2002: Akiyo S Penner; Matthew J Rock; Cay M Kielty; J Michael Shipley
Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.
The Journal of biological chemistry 2002;277(38):35044-9.
2002: Cay M Kielty; Michael J Sherratt; C Adrian Shuttleworth
Elastic fibres.
Journal of cell science 2002;115(Pt 14):2817-28.
2002: Jonathan Hill; Martyn Lewis; Pauline Mills; Cay M Kielty
Pulsed short-wave diathermy effects on human fibroblast proliferation.
Archives of physical medicine and rehabilitation 2002;83(6):832-6.
2002: Clair Baldock; CJ Gilpin; Abraham Koster; Ulrike Ziese; Karl Kadler; Cay M Kielty; David F Holmes
Three-dimensional reconstructions of extracellular matrix polymers using automated electron tomography.
Journal of structural biology 2002;138(1-2):130-6.
2002: Sanjay Sinha; Anthony M Heagerty; C Adrian Shuttleworth; Cay M Kielty
Expression of latent TGF-beta binding proteins and association with TGF-beta 1 and fibrillin-1 following arterial injury.
Cardiovascular research 2002;53(4):971-83.
2002: Cay M Kielty; Clair Baldock; David Lee; Matthew J Rock; Jane L Ashworth; C Adrian Shuttleworth
Fibrillin: from microfibril assembly to biomechanical function.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2002;357(1418):207-17.
2002: Cay M Kielty; Tim J Wess; L Haston; Jane L Ashworth; Michael J Sherratt; C Adrian Shuttleworth
Fibrillin-rich microfibrils: elastic biopolymers of the extracellular matrix.
Journal of muscle research and cell motility 2002;23(5-6):581-96.
2001: S Sinha; Cay M Kielty; Anthony M Heagerty; Ann E Canfield; C Adrian Shuttleworth
Upregulation of collagen VIII following porcine coronary artery angioplasty is related to smooth muscle cell migration not angiogenesis.
International journal of experimental pathology 2001;82(5):295-302.
2001: Rachel E B Watson; Nicholas M Craven; Sewon Kang; CJ Jones; Cay M Kielty; Christopher E M Griffiths
A short-term screening protocol, using fibrillin-1 as a reporter molecule, for photoaging repair agents.
The Journal of investigative dermatology 2001;116(5):672-8.
2001: Chris Illidge; Cay M Kielty; Adrian Shuttleworth
Type VIII collagen: heterotrimeric chain association.
The international journal of biochemistry & cell biology 2001;33(5):521-9.
2001: Rachel E B Watson; S G Ball; Nicholas M Craven; J Boorsma; C L East; C Adrian Shuttleworth; Cay M Kielty; Christopher E M Griffiths
Distribution and expression of type VI collagen in photoaged skin.
The British journal of dermatology 2001;144(4):751-9.
2001: S S Chaudhry; J Gazzard; Clair Baldock; Jill Dixon; Matthew J Rock; G C Skinner; K P Steel; Cay M Kielty; Michael J Dixon
Mutation of the gene encoding fibrillin-2 results in syndactyly in mice.
Human molecular genetics 2001;10(8):835-43.
2001: Clair Baldock; Abraham Koster; Ulrike Ziese; Matthew J Rock; Michael J Sherratt; Karl Kadler; C Adrian Shuttleworth; Cay M Kielty
The supramolecular organization of fibrillin-rich microfibrils.
The Journal of cell biology 2001;152(5):1045-56.
2001: Michael J Sherratt; Tim J Wess; Clair Baldock; Jane L Ashworth; Peter P Purslow; C Adrian Shuttleworth; Cay M Kielty
Fibrillin-rich microfibrils of the extracellular matrix: ultrastructure and assembly.
Micron (Oxford, England : 1993) 2001;32(2):185-200.
2000: Michael J Sherratt; HK Graham; Cay M Kielty; David F Holmes
ECM macromolecules: rotary shadowing and scanning transmission electron microscopy.
Methods in molecular biology (Clifton, N.J.) 2000;139():119-32.
1999: A Shuttleworth; S Ball; C Baldock; Hana Fakhoury; Cay M Kielty
Functional role of A-domains in type VI collagen.
Biochemical Society transactions 1999;27(6):821-3.
1999: Jane L Ashworth; V Kelly; Matthew J Rock; C Adrian Shuttleworth; Cay M Kielty
Regulation of fibrillin carboxy-terminal furin processing by N-glycosylation, and association of amino- and carboxy-terminal sequences.
Journal of cell science 1999;112 ( Pt 22)():4163-71.
1999: D M Wright; Victor C Duance; Tim J Wess; Cay M Kielty; Peter P Purslow
The supramolecular organisation of fibrillin-rich microfibrils determines the mechanical properties of bovine zonular filaments.
The Journal of experimental biology 1999;202(Pt 21):3011-20.
1999: Jane L Ashworth; V Kelly; R Wilson; C Adrian Shuttleworth; Cay M Kielty
Fibrillin assembly: dimer formation mediated by amino-terminal sequences.
Journal of cell science 1999;112 ( Pt 20)():3549-58.
1999: Vincent J Hindson; Jane L Ashworth; Matthew J Rock; S Cunliffe; C Adrian Shuttleworth; Cay M Kielty
Fibrillin degradation by matrix metalloproteinases: identification of amino- and carboxy-terminal cleavage sites.
FEBS letters 1999;452(3):195-8.
1999: Jane L Ashworth; G Murphy; Matthew J Rock; Michael J Sherratt; S D Shapiro; C Adrian Shuttleworth; Cay M Kielty
Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling.
The Biochemical journal 1999;340 ( Pt 1)():171-81.
1999: Rachel E B Watson; Christopher E M Griffiths; Nicholas M Craven; C Adrian Shuttleworth; Cay M Kielty
Fibrillin-rich microfibrils are reduced in photoaged skin. Distribution at the dermal-epidermal junction.
The Journal of investigative dermatology 1999;112(5):782-7.
1998: S Sinha; C Nevett; C Adrian Shuttleworth; Cay M Kielty
Cellular and extracellular biology of the latent transforming growth factor-beta binding proteins.
Matrix biology : journal of the International Society for Matrix Biology 1998;17(8-9):529-45.
1998: Chris Illidge; Cay M Kielty; Adrian Shuttleworth
The alpha1(VIII) and alpha2(VIII) chains of type VIII collagen can form stable homotrimeric molecules.
The Journal of biological chemistry 1998;273(34):22091-5.
1998: Rachel E B Watson; EJ Parry; JD Humphries; CJ Jones; D W Polson; Cay M Kielty; Christopher E M Griffiths
Fibrillin microfibrils are reduced in skin exhibiting striae distensae.
The British journal of dermatology 1998;138(6):931-7.
1998: Tim J Wess; Peter P Purslow; Michael J Sherratt; Jane L Ashworth; C Adrian Shuttleworth; Cay M Kielty
Calcium determines the supramolecular organization of fibrillin-rich microfibrils.
The Journal of cell biology 1998;141(3):829-37.
1998: Cay M Kielty; M Raghunath; Linda D Siracusa; Michael J Sherratt; R Peters; C Adrian Shuttleworth; S A Jimenez
The Tight skin mouse: demonstration of mutant fibrillin-1 production and assembly into abnormal microfibrils.
The Journal of cell biology 1998;140(5):1159-66.
1998: Tim J Wess; Peter P Purslow; Cay M Kielty
X-Ray diffraction studies of fibrillin-rich microfibrils: effects of tissue extension on axial and lateral packing.
Journal of structural biology 1998;122(1-2):123-7.
1998: Cay M Kielty; E Hanssen; C Adrian Shuttleworth
Purification of fibrillin-containing microfibrils and collagen VI microfibrils by density gradient centrifugation.
Analytical biochemistry 1998;255(1):108-12.
1997: Gillian S Ashcroft; Cay M Kielty; Michael A Horan; Mark W J Ferguson
Age-related changes in the temporal and spatial distributions of fibrillin and elastin mRNAs and proteins in acute cutaneous wounds of healthy humans.
The Journal of pathology 1997;183(1):80-9.
1997: Nicholas M Craven; Rachel E B Watson; CJ Jones; C Adrian Shuttleworth; Cay M Kielty; Christopher E M Griffiths
Clinical features of photodamaged human skin are associated with a reduction in collagen VII.
The British journal of dermatology 1997;137(3):344-50.
1997: Tim J Wess; Peter P Purslow; Cay M Kielty
Fibrillin-rich microfibrils: an X-ray diffraction study of the fundamental axial periodicity.
FEBS letters 1997;413(3):424-8.
1997: Cay M Kielty; C Adrian Shuttleworth
Microfibrillar elements of the dermal matrix.
Microscopy research and technique 1997;38(4):413-27.
1997: Michael J Sherratt; David F Holmes; C Adrian Shuttleworth; Cay M Kielty
Scanning transmission electron microscopy mass analysis of fibrillin-containing microfibrils from foetal elastic tissues.
The international journal of biochemistry & cell biology 1997;29(8-9):1063-70.
1997: S L Haynes; C Adrian Shuttleworth; Cay M Kielty
Keratinocytes express fibrillin and assemble microfibrils: implications for dermal matrix organization.
The British journal of dermatology 1997;137(1):17-23.
1996: P Bishop; S Ayad; AJ Reardon; david mcleod; J Sheehan; Cay M Kielty
Type VI collagen is present in human and bovine vitreous.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 1996;234(11):710-3.
1996: J R MacBeath; Cay M Kielty; C Adrian Shuttleworth
Type VIII collagen is a product of vascular smooth-muscle cells in development and disease.
The Biochemical journal 1996;319 ( Pt 3)():993-8.
1996: L Lönnqvist; L Karttunen; T Rantamäki; Cay M Kielty; Michael Raghunath; Leena Peltonen
A point mutation creating an extra N-glycosylation site in fibrillin-1 results in neonatal Marfan syndrome.
Genomics 1996;36(3):468-75.
1996: Cay M Kielty; S P Whittaker; C Adrian Shuttleworth
Fibrillin: evidence that chondroitin sulphate proteoglycans are components of microfibrils and associate with newly synthesised monomers.
FEBS letters 1996;386(2-3):169-73.
1995: J R Macbeath; Cay M Kielty; C Adrian Shuttleworth
Structure and organisation of type VIII collagen.
Biochemical Society transactions 1995;23(4):513S.
1995: C E Dyer; C Adrian Shuttleworth; Cay M Kielty
Conformation and function of fibrillin 8-cysteine motifs.
Biochemical Society transactions 1995;23(4):506S.
1995: Cay M Kielty; C Adrian Shuttleworth
Fibrillin-containing microfibrils: structure and function in health and disease.
The international journal of biochemistry & cell biology 1995;27(8):747-60.
1995: Michael Raghunath; Cay M Kielty; Beat Steinmann
Truncated profibrillin of a Marfan patient is of apparent similar size as fibrillin: intracellular retention leads to over-N-glycosylation.
Journal of molecular biology 1995;248(5):901-9.
1995: Cay M Kielty; T Rantamäki; A H Child; C Adrian Shuttleworth; Leena Peltonen
Cysteine-to-arginine point mutation in a 'hybrid' eight-cysteine domain of FBN1: consequences for fibrillin aggregation and microfibril assembly.
Journal of cell science 1995;108 ( Pt 3)():1317-23.
1995: Cay M Kielty; S J Davies; J E Phillips; CJ Jones; C Adrian Shuttleworth; S J Charles
Marfan syndrome: fibrillin expression and microfibrillar abnormalities in a family with predominant ocular defects.
Journal of medical genetics 1995;32(1):1-6.
1994: Michael Raghunath; Cay M Kielty; K Kainulainen; A Child; Leena Peltonen; Beat Steinmann
Analyses of truncated fibrillin caused by a 366 bp deletion in the FBN1 gene resulting in Marfan syndrome.
The Biochemical journal 1994;302 ( Pt 3)():889-96.
1994: Cay M Kielty; D E Woolley; S P Whittaker; C Adrian Shuttleworth
Catabolism of intact fibrillin microfibrils by neutrophil elastase, chymotrypsin and trypsin.
FEBS letters 1994;351(1):85-9.
1994: Cay M Kielty; C Adrian Shuttleworth
Abnormal fibrillin assembly by dermal fibroblasts from two patients with Marfan syndrome.
The Journal of cell biology 1994;124(6):997-1004.
1994: Cay M Kielty; J E Phillips; A H Child; F Michael Pope; C Adrian Shuttleworth
Fibrillin secretion and microfibril assembly by Marfan dermal fibroblasts.
Matrix biology : journal of the International Society for Matrix Biology 1994;14(2):191-9.
1993: Cay M Kielty; C Adrian Shuttleworth
The role of calcium in the organization of fibrillin microfibrils.
FEBS letters 1993;336(2):323-6.
1993: Cay M Kielty; C Adrian Shuttleworth
Synthesis and assembly of fibrillin by fibroblasts and smooth muscle cells.
Journal of cell science 1993;106 ( Pt 1)():167-73.
1993: A D Waggett; Cay M Kielty; C Adrian Shuttleworth
Microfibrillar elements in the synovial joint: presence of type VI collagen and fibrillin-containing microfibrils.
Annals of the rheumatic diseases 1993;52(6):449-53.
1993: Cay M Kielty; L Berry; S P Whittaker; Michael E Grant; C Adrian Shuttleworth
Microfibrillar assemblies of foetal bovine skin. Developmental expression and relative abundance of type VI collagen and fibrillin.
Matrix (Stuttgart, Germany) 1993;13(2):103-12.
1992: C Adrian Shuttleworth; L Berry; Cay M Kielty
Microfibrillar components in dental pulp: presence of both type VI collagen- and fibrillin-containing microfibrils.
Archives of oral biology 1992;37(12):1079-84.
1992: Cay M Kielty; S P Whittaker; Michael E Grant; C Adrian Shuttleworth
Attachment of human vascular smooth muscles cells to intact microfibrillar assemblies of collagen VI and fibrillin.
Journal of cell science 1992;103 ( Pt 2)():445-51.
1992: Cay M Kielty; S P Whittaker; Michael E Grant; C Adrian Shuttleworth
Type VI collagen microfibrils: evidence for a structural association with hyaluronan.
The Journal of cell biology 1992;118(4):979-90.
1991: Cay M Kielty; S P Whittaker; Michael E Grant; C Adrian Shuttleworth
Type VI collagen forms a structural association with hyaluronan in vivo.
Biochemical Society transactions 1991;19(4):384S.
1991: Cay M Kielty; C Adrian Shuttleworth; Michael E Grant
Studies on microfibrils of developing bovine elastic tissues.
Biochemical Society transactions 1991;19(4):383S.
1991: Cay M Kielty; C Adrian Shuttleworth; Michael E Grant
A collagenase-sensitive glycoprotein identified in foetal bovine cell cultures.
Biochemical Society transactions 1991;19(4):385S.
1991: Cay M Kielty; C Cummings; S P Whittaker; C Adrian Shuttleworth; Michael E Grant
Isolation and ultrastructural analysis of microfibrillar structures from foetal bovine elastic tissues. Relative abundance and supramolecular architecture of type VI collagen assemblies and fibrillin.
Journal of cell science 1991;99 ( Pt 4)():797-807.
1990: Cay M Kielty; Raymond P Boot-Handford; S Ayad; C Adrian Shuttleworth; Michael E Grant
Molecular composition of type VI collagen. Evidence for chain heterogeneity in mammalian tissues and cultured cells.
The Biochemical journal 1990;272(3):787-95.
1985: Cay M Kielty; A P Kwan; David F Holmes; S L Schor; Michael E Grant
Type X collagen, a product of hypertrophic chondrocytes.
The Biochemical journal 1985;227(2):545-54.