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Akira Kikuchi

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Chemicals & Drugs

Physiology

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Co-Publications
Name
47
Takai, Yoshimi
28
Kishida, Shosei
27
Yamamoto, Hideki
18
Koyama, Shinya
16
Asashima, Makoto
14
Michiue, Tatsuo
12
Sasaki, Takuya
11
Fukui, Akimasa
10
Kishida, M
9
Kuroda, Shun'ichi
9
Hinoi, T
8
Asahara, Toshimasa
8
Ikeda, Satoshi
7
Juji, Takeo
7
Nieda, Mie

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Publications

TOP 3
Kikuchi Akira
[Wnt signaling; its abnormalities and diseases]
Yamamoto Hideki; Kitadai Yasuhiko; Yamamoto Hideki; Oue Naohide; Ohdan Hideki; Yasui Wataru; Kikuchi Akira
Laminin gamma2 mediates Wnt5a-induced invasion of gastric cancer cells.
Fumoto Katsumi; Kadono Moe; Izumi Nanae; Kikuchi Akira
Axin localizes to the centrosome and is involved in microtubule nucleation.

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All Publications

2009: Kikuchi Akira
[Wnt signaling; its abnormalities and diseases]
Seikagaku. The Journal of Japanese Biochemical Society 2009;81(9):780-92.
2009: Yamamoto Hideki; Kitadai Yasuhiko; Yamamoto Hideki; Oue Naohide; Ohdan Hideki; Yasui Wataru; Kikuchi Akira
Laminin gamma2 mediates Wnt5a-induced invasion of gastric cancer cells.
Gastroenterology 2009;137(1):242-52, 252.e1-6.
2009: Fumoto Katsumi; Kadono Moe; Izumi Nanae; Kikuchi Akira
Axin localizes to the centrosome and is involved in microtubule nucleation.
EMBO reports 2009;10(6):606-13.
2009: Noguchi Tsuyoshi; Oue Naohide; Wada Shinsuke; Sentani Kazuhiro; Sakamoto Naoya; Kikuchi Akira; Yasui Wataru
h-Prune is an independent prognostic marker for survival in esophageal squamous cell carcinoma.
Annals of surgical oncology 2009;16(5):1390-6.
2009: Kikuchi Akira; Yamamoto Hideki; Sato Akira
Selective activation mechanisms of Wnt signaling pathways.
Trends in cell biology 2009;19(3):119-29.
2008: Okutsu Rie; Rai Tatemitsu; Kikuchi Akira; Ohno Mayuko; Uchida Keiko; Sasaki Sei; Uchida Shinichi
AKAP220 colocalizes with AQP2 in the inner medullary collecting ducts.
Kidney international 2008;74(11):1429-33.
2008: Chen Yuyan; Takita Junko; Choi Young Lim; Kato Motohiro; Ohira Miki; Sanada Masashi; Wang Lili; Soda Manabu; Kikuchi Akira; Igarashi Takashi; Nakagawara Akira; Hayashi Yasuhide; Mano Hiroyuki; Ogawa Seishi
Oncogenic mutations of ALK kinase in neuroblastoma.
Nature 2008;455(7215):971-4.
2008: Hatano Hiroko; Kudo Yasusei; Ogawa Ikuko; Tsunematsu Takaaki; Kikuchi Akira; Abiko Yoshimitsu; Takata Takashi
IFN-induced transmembrane protein 1 promotes invasion at early stage of head and neck cancer progression.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(19):6097-105.
2008: Ohtsubo Motoaki; Yasunaga Shin'ichiro; Ohno Yoshinori; Tsumura Miyuki; Okada Satoshi; Ishikawa Nobutsune; Shirao Kenichiro; Kikuchi Akira; Nishitani Hideo; Kobayashi Masao; Takihara Yoshihiro
Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(30):10396-401.
2008: Yamamoto Hideki; Sakane Hiroshi; Yamamoto Hideki; Michiue Tatsuo; Kikuchi Akira
Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling.
Developmental cell 2008;15(1):37-48.
2008: Fumoto K; Lee P-C; Saya H; Kikuchi A
AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-3beta.
Oncogene 2008;27(32):4478-87.
2008: Izumi Nanae; Fumoto Katsumi; Izumi Shunsuke; Kikuchi Akira
GSK-3beta regulates proper mitotic spindle formation in cooperation with a component of the gamma-tubulin ring complex, GCP5.
The Journal of biological chemistry 2008;283(19):12981-91.
2008: Kikuchi Akira; Yamamoto Hideki
Tumor formation due to abnormalities in the beta-catenin-independent pathway of Wnt signaling.
Cancer science 2008;99(2):202-8.
2007: Oue Naohide; Yoshida Kazuhiro; Noguchi Tsuyoshi; Sentani Kazuhiro; Kikuchi Akira; Yasui Wataru
Increased expression of h-prune is associated with tumor progression and poor survival in gastric cancer.
Cancer science 2007;98(8):1198-205.
2007: Ihara Motomasa; Koyama Hirofumi; Uchimura Yasuhiro; Saitoh Hisato; Kikuchi Akira
Noncovalent binding of small ubiquitin-related modifier (SUMO) protease to SUMO is necessary for enzymatic activities and cell growth.
The Journal of biological chemistry 2007;282(22):16465-75.
2007: Komekado Hideyuki; Yamamoto Hideki; Chiba Tsutomu; Kikuchi Akira
Glycosylation and palmitoylation of Wnt-3a are coupled to produce an active form of Wnt-3a.
Genes to cells : devoted to molecular & cellular mechanisms 2007;12(4):521-34.
2007: Kikuchi Akira; Yamamoto Hideki
Regulation of Wnt signalling by receptor-mediated endocytosis.
Journal of biochemistry 2007;141(4):443-51.
2007: Kikuchi Akira; Yamamoto Hideki; Kishida Shosei
Multiplicity of the interactions of Wnt proteins and their receptors.
Cellular signalling 2007;19(4):659-71.
2007: Kurayoshi Manabu; Yamamoto Hideki; Izumi Shunsuke; Kikuchi Akira
Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling.
The Biochemical journal 2007;402(3):515-23.
2007: Kishida Shosei; Hamao Kozue; Inoue Makoto; Hasegawa Mamoru; Matsuura Yoshiharu; Mikoshiba Katsuhiko; Fukuda Mitsunori; Kikuchi Akira
Dvl regulates endo- and exocytotic processes through binding to synaptotagmin.
Genes to cells : devoted to molecular & cellular mechanisms 2007;12(1):49-61.
2006: Fumoto Katsumi; Hoogenraad Casper C; Kikuchi Akira
GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome.
The EMBO journal 2006;25(24):5670-82.
2006: Kurayoshi Manabu; Oue Naohide; Yamamoto Hideki; Kishida Michiko; Inoue Atsuko; Asahara Toshimasa; Yasui Wataru; Kikuchi Akira
Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion.
Cancer research 2006;66(21):10439-48.
2006: Yamamoto Hideki; Komekado Hideyuki; Kikuchi Akira
Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin.
Developmental cell 2006;11(2):213-23.
2006: Chen Yuyan; Takita Junko; Hiwatari Mitsuteru; Igarashi Takashi; Hanada Ryoji; Kikuchi Akira; Hongo Teruaki; Taki Tomohiko; Ogasawara Mizuho; Shimada Akira; Hayashi Yasuhide
Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignancies.
Genes, chromosomes & cancer 2006;45(6):583-91.
2006: Nakajima-Adachi Haruyo; Ebihara Ayumi; Kikuchi Akira; Ishida Tsuyoshi; Sasaki Kiyomi; Hirano Kiyomi; Watanabe Hiroko; Asai Kazumi; Takahashi Yoshimasa; Kanamori Yutaka; Shimojo Naoki; Matsuda Hiroshi; Kohno Yoichi; Hachimura Satoshi; Kaminogawa Shuichi
Food antigen causes TH2-dependent enteropathy followed by tissue repair in T-cell receptor transgenic mice.
The Journal of allergy and clinical immunology 2006;117(5):1125-32.
2006: Kikuchi Akira; Kishida Shosei; Yamamoto Hideki
Regulation of Wnt signaling by protein-protein interaction and post-translational modifications.
Experimental & molecular medicine 2006;38(1):1-10.
2006: Yamashina Keitaro; Yamamoto Hideki; Chayama Kazuaki; Nakajima Koichi; Kikuchi Akira
Suppression of STAT3 activity by Duplin, which is a negative regulator of the Wnt signal.
Journal of biochemistry 2006;139(2):305-14.
2006: Kobayashi Tsuyoshi; Hino Shin-ichiro; Oue Naohide; Asahara Toshimasa; Zollo Massimo; Yasui Wataru; Kikuchi Akira
Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions.
Molecular and cellular biology 2006;26(3):898-911.
2005: Hino Shin-ichiro; Tanji Chie; Nakayama Keiichi I; Kikuchi Akira
Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination.
Molecular and cellular biology 2005;25(20):9063-72.
2005: Kobayashi Hiroki; Michiue Tatsuo; Yukita Akira; Danno Hiroki; Sakurai Kenji; Fukui Akimasa; Kikuchi Akira; Asashima Makoto
Novel Daple-like protein positively regulates both the Wnt/beta-catenin pathway and the Wnt/JNK pathway in Xenopus.
Mechanisms of development 2005;122(10):1138-53.
2005: Chen Yu Yan; Takita Junko; Tanaka Kiyoshi; Ida Kohmei; Koh Katsuyoshi; Igarashi Takashi; Hanada Ryoji; Kikuchi Akira; Tanaka Yukichi; Toyoda Yasunori; Hayashi Yasuhide
Aberrations of the CHK2 gene are rare in pediatric solid tumors.
International journal of molecular medicine 2005;16(1):85-91.
2005: Ihara Motomasa; Yamamoto Hideki; Kikuchi Akira
SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4.
Molecular and cellular biology 2005;25(9):3506-18.
2005: Sugiyama Shinichiro; Kishida Shosei; Chayama Kazuaki; Koyama Shinya; Kikuchi Akira
Ubiquitin-interacting motifs of Epsin are involved in the regulation of insulin-dependent endocytosis.
Journal of biochemistry 2005;137(3):355-64.
2004: Yukita Akira; Michiue Tatsuo; Fukui Akimasa; Sakurai Kenji; Yamamoto Hideki; Ihara Motomasa; Kikuchi Akira; Asashima Makoto
XSENP1, a novel sumo-specific protease in Xenopus, inhibits normal head formation by down-regulation of Wnt/beta-catenin signalling.
Genes to cells : devoted to molecular & cellular mechanisms 2004;9(8):723-36.
2004: Hirabayashi Susumu; Nishimura Wataru; Iida Junko; Kansaku Ai; Kishida Shosei; Kikuchi Akira; Tanaka Noriaki; Hata Yutaka
Synaptic scaffolding molecule interacts with axin.
Journal of neurochemistry 2004;90(2):332-9.
2004: Sato Akira; Kishida Shosei; Tanaka Toshiya; Kikuchi Akira; Kodama Tatsuhiko; Asashima Makoto; Nishinakamura Ryuichi
Sall1, a causative gene for Townes-Brocks syndrome, enhances the canonical Wnt signaling by localizing to heterochromatin.
Biochemical and biophysical research communications 2004;319(1):103-13.
2004: Kishida Shosei; Yamamoto Hideki; Kikuchi Akira
Wnt-3a and Dvl induce neurite retraction by activating Rho-associated kinase.
Molecular and cellular biology 2004;24(10):4487-501.
2004: Michiue Tatsuo; Fukui Akimasa; Yukita Akira; Sakurai Kenji; Danno Hiroki; Kikuchi Akira; Asashima Makoto
XIdax, an inhibitor of the canonical Wnt pathway, is required for anterior neural structure formation in Xenopus.
Developmental dynamics : an official publication of the American Association of Anatomists 2004;230(1):79-90.
2004: Ishizaki Yasuyo; Ikeda Satoshi; Fujimori Masahiko; Shimizu Yosuke; Kurihara Takeshi; Itamoto Toshiyuki; Kikuchi Akira; Okajima Masazumi; Asahara Toshimasa
Immunohistochemical analysis and mutational analyses of beta-catenin, Axin family and APC genes in hepatocellular carcinomas.
International journal of oncology 2004;24(5):1077-83.
2004: Sakurai Kenji; Michiue Tatsuo; Kikuchi Akira; Asashima Makoto
Inhibition of the canonical Wnt signaling pathway in cytoplasm: a novel property of the carboxyl terminal domains of two Xenopus ELL genes.
Zoological science 2004;21(4):407-16.
2004: Kikuchi Akira; Nakajima-Adachi Haruyo; Ebihara Ayumi; Takahashi Yoshimasa; Hosono Akira; Itoh Kikuji; Hachimura Satoshi; Kaminogawa Shuichi
Oral administration of food antigen induces T cell mediated intestinal inflammation: a model using TCR-transgenic mice.
BioFactors (Oxford, England) 2004;21(1-4):159-62.
2003: Oshita Akihiko; Kishida Shosei; Kobayashi Hiroki; Michiue Tatsuo; Asahara Toshimasa; Asashima Makoto; Kikuchi Akira
Identification and characterization of a novel Dvl-binding protein that suppresses Wnt signalling pathway.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(12):1005-17.
2003: Nagano Yoshito; Yamashita Hiroshi; Takahashi Tetsuya; Kishida Shosei; Nakamura Takeshi; Iseki Eizo; Hattori Nobutaka; Mizuno Yoshikuni; Kikuchi Akira; Matsumoto Masayasu
Siah-1 facilitates ubiquitination and degradation of synphilin-1.
The Journal of biological chemistry 2003;278(51):51504-14.
2003: Yamamoto Hideki; Ihara Motomasa; Matsuura Yoshiharu; Kikuchi Akira
Sumoylation is involved in beta-catenin-dependent activation of Tcf-4.
The EMBO journal 2003;22(9):2047-59.
2003: Hino Shin-ichiro; Michiue Tatsuo; Asashima Makoto; Kikuchi Akira
Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin.
The Journal of biological chemistry 2003;278(16):14066-73.
2003: Kikuchi Akira
Tumor formation by genetic mutations in the components of the Wnt signaling pathway.
Cancer science 2003;94(3):225-9.
2003: Hirata Yuzoh; Andoh Tomoko; Asahara Toshimasa; Kikuchi Akira
Yeast glycogen synthase kinase-3 activates Msn2p-dependent transcription of stress responsive genes.
Molecular biology of the cell 2003;14(1):302-12.
2002: Okai M; Nieda M; Tazbirkova A; Horley D; Kikuchi A; Durrant S; Takahashi T; Boyd A; Abraham R; Yagita H; Juji T; Nicol A
Human peripheral blood Valpha24+ Vbeta11+ NKT cells expand following administration of alpha-galactosylceramide-pulsed dendritic cells.
Vox sanguinis 2002;83(3):250-3.
2002: Oshiro Takafumi; Koyama Shinya; Sugiyama Shinichiro; Kondo Akiko; Onodera Yasuhito; Asahara Toshimasa; Sabe Hisataka; Kikuchi Akira
Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration.
The Journal of biological chemistry 2002;277(41):38618-26.
2002: Tanji Chie; Yamamoto Hideki; Yorioka Noriaki; Kohno Nobuoki; Kikuchi Kunimi; Kikuchi Akira
A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta.
The Journal of biological chemistry 2002;277(40):36955-61.
2002: Taketani Takeshi; Taki Tomohiko; Shibuya Noriko; Kikuchi Akira; Hanada Ryoji; Hayashi Yasuhide
Novel NUP98-HOXC11 fusion gene resulted from a chromosomal break within exon 1 of HOXC11 in acute myeloid leukemia with t(11;12)(p15;q13).
Cancer research 2002;62(16):4571-4.
2002: Andoh Tomoko; Hirata Yuzoh; Kikuchi Akira
PY motifs of Rod1 are required for binding to Rsp5 and for drug resistance.
FEBS letters 2002;525(1-3):131-4.
2002: Ma F; Manabe A; Wang D; Ito M; Kikuchi A; Wada M; Ito M; Ohara A; Hosoya R; Asano S; Tsuji K
Growth of human T cell acute lymphoblastic leukemia lymphoblasts in NOD/SCID mouse fetal thymus organ culture.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2002;16(8):1541-8.
2002: Kadoya Takayuki; Yamamoto Hideki; Suzuki Toshiaki; Yukita Akira; Fukui Akimasa; Michiue Tatsuo; Asahara Toshimasa; Tanaka Keiji; Asashima Makoto; Kikuchi Akira
Desumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of beta-catenin.
Molecular and cellular biology 2002;22(11):3803-19.
2002: Kobayashi Masashi; Kishida Shosei; Fukui Akimasa; Michiue Tatsuo; Miyamoto Yoichi; Okamoto Tetsuji; Yoneda Yoshihiro; Asashima Makoto; Kikuchi Akira
Nuclear localization of Duplin, a beta-catenin-binding protein, is essential for its inhibitory activity on the Wnt signaling pathway.
The Journal of biological chemistry 2002;277(8):5816-22.
2001: Kikuchi A; Nieda M; Schmidt C; Koezuka Y; Ishihara S; Ishikawa Y; Tadokoro K; Durrant S; Boyd A; Juji T; Nicol A
In vitro anti-tumour activity of alpha-galactosylceramide-stimulated human invariant Valpha24+NKT cells against melanoma.
British journal of cancer 2001;85(5):741-6.
2001: Kishida M; Hino Si; Michiue T; Yamamoto H; Kishida S; Fukui A; Asashima M; Kikuchi A
Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon.
The Journal of biological chemistry 2001;276(35):33147-55.
2001: Lapteva N; Ando Y; Nieda M; Hohjoh H; Okai M; Kikuchi A; Dymshits G; Ishikawa Y; Juji T; Tokunaga K
Profiling of genes expressed in human monocytes and monocyte-derived dendritic cells using cDNA expression array.
British journal of haematology 2001;114(1):191-7.
2001: Yamamoto H; Hinoi T; Michiue T; Fukui A; Usui H; Janssens V; Van Hoof C; Goris J; Asashima M; Kikuchi A
Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A.
The Journal of biological chemistry 2001;276(29):26875-82.
2001: Kawamura Y; Kikuchi A; Takada R; Takada S; Sudoh S; Shibamoto S; Yanagisawa K; Komano H
Inhibitory effect of a presenilin 1 mutation on the Wnt signalling pathway by enhancement of beta-catenin phosphorylation.
European journal of biochemistry / FEBS 2001;268(10):3036-41.
2001: Nieda M; Nicol A; Koezuka Y; Kikuchi A; Lapteva N; Tanaka Y; Tokunaga K; Suzuki K; Kayagaki N; Yagita H; Hirai H; Juji T
TRAIL expression by activated human CD4(+)V alpha 24NKT cells induces in vitro and in vivo apoptosis of human acute myeloid leukemia cells.
Blood 2001;97(7):2067-74.
2001: Nieda M; Kikuchi A; nicol A; Koezuka Y; Ando Y; Ishihara S; Lapteva N; Yabe T; Tokunaga K; Tadokoro K; Juji T
Dendritic cells rapidly undergo apoptosis in vitro following culture with activated CD4+ Valpha24 natural killer T cells expressing CD40L.
Immunology 2001;102(2):137-45.
2001: Itoh T; Koshiba S; Kigawa T; Kikuchi A; Yokoyama S; Takenawa T
Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis.
Science (New York, N.Y.) 2001;291(5506):1047-51.
2001: Hino S; Kishida S; Michiue T; Fukui A; Sakamoto I; Takada S; Asashima M; Kikuchi A
Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein.
Molecular and cellular biology 2001;21(1):330-42.
2001: Koyano Y; Kawamoto T; Kikuchi A; Shen M; Kuruta Y; Tsutsumi S; Fujimoto K; Noshiro M; Fujii K; Kato Y
Chondrocyte-derived ezrin-like domain containing protein (CDEP), a rho guanine nucleotide exchange factor, is inducible in chondrocytes by parathyroid hormone and cyclic AMP and has transforming activity in NIH3T3 cells.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9 Suppl A():S64-8.
2001: Koyama S; Kikuchi A
Ras interaction with RalGDS effector targets.
Methods in enzymology 2001;332():127-38.
2000: Murata-Hori M; Fumoto K; Fukuta Y; Iwasaki T; Kikuchi A; Tatsuka M; Hosoya H
Myosin II regulatory light chain as a novel substrate for AIM-1, an aurora/Ipl1p-related kinase from rat.
Journal of biochemistry 2000;128(6):903-7.
2000: Kadoya T; Kishida S; Fukui A; Hinoi T; Michiue T; Asashima M; Kikuchi A
Inhibition of Wnt signaling pathway by a novel axin-binding protein.
The Journal of biological chemistry 2000;275(47):37030-7.
2000: Hinoi T; Yamamoto H; Kishida M; Takada S; Kishida S; Kikuchi A
Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3 beta-dependent phosphorylation of beta-catenin and down-regulates beta-catenin.
The Journal of biological chemistry 2000;275(44):34399-406.
2000: Fukui A; Kishida S; Kikuchi A; Asashima M
Effects of rat Axin domains on axis formation in Xenopus embryos.
Development, growth & differentiation 2000;42(5):489-98.
2000: Sakamoto I; Kishida S; Fukui A; Kishida M; Yamamoto H; Hino S; Michiue T; Takada S; Asashima M; Kikuchi A
A novel beta-catenin-binding protein inhibits beta-catenin-dependent Tcf activation and axis formation.
The Journal of biological chemistry 2000;275(42):32871-8.
2000: Andoh T; Hirata Y; Kikuchi A
Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5.
Molecular and cellular biology 2000;20(18):6712-20.
2000: Kariya K; Koyama S; Nakashima S; Oshiro T; Morinaka K; Kikuchi A
Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation.
The Journal of biological chemistry 2000;275(24):18399-406.
2000: Ebihara Y; Xu M J; Manabe A; Kikuchi A; Tanaka R; Kato S; Nakahata T; Tsuji K
Exclusive expression of G-CSF receptor on myeloid progenitors in bone marrow CD34+ cells.
British journal of haematology 2000;109(1):153-61.
2000: Kikuchi A
Regulation of beta-catenin signaling in the Wnt pathway.
Biochemical and biophysical research communications 2000;268(2):243-8.
2000: Ikeda S; Kishida M; Matsuura Y; Usui H; Kikuchi A
GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin.
Oncogene 2000;19(4):537-45.
1999: Kikuchi A
Roles of Axin in the Wnt signalling pathway.
Cellular signalling 1999;11(11):777-88.
1999: Morinaka K; Koyama S; Nakashima S; Hinoi T; Okawa K; Iwamatsu A; Kikuchi A
Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis.
Oncogene 1999;18(43):5915-22.
1999: Kikuchi A
Modulation of Wnt signaling by Axin and Axil.
Cytokine & growth factor reviews 1999;10(3-4):255-65.
1999: Kodama S; Ikeda S; Asahara T; Kishida M; Kikuchi A
Axin directly interacts with plakoglobin and regulates its stability.
The Journal of biological chemistry 1999;274(39):27682-8.
1999: Yang F C; Tsuji K; Oda A; Ebihara Y; Xu M J; Kaneko A; Hanada S; Mitsui T; Kikuchi A; Manabe A; Watanabe S; Ikeda Y; Nakahata T
Differential effects of human granulocyte colony-stimulating factor (hG-CSF) and thrombopoietin on megakaryopoiesis and platelet function in hG-CSF receptor-transgenic mice.
Blood 1999;94(3):950-8.
1999: Nakashima S; Morinaka K; Koyama S; Ikeda M; Kishida M; Okawa K; Iwamatsu A; Kishida S; Kikuchi A
Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors.
The EMBO journal 1999;18(13):3629-42.
1999: Kishida S; Yamamoto H; Hino S; Ikeda S; Kishida M; Kikuchi A
DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability.
Molecular and cellular biology 1999;19(6):4414-22.
1999: Murata-Hori M; Suizu F; Iwasaki T; Kikuchi A; Hosoya H
ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells.
FEBS letters 1999;451(1):81-4.
1999: Shirouzu M; Hashimoto K; Kikuchi A; Yokoyama S
Double-mutant analysis of the interaction of Ras with the Ras-binding domain of RGL.
Biochemistry 1999;38(16):5103-10.
1999: Yamamoto H; Kishida S; Kishida M; Ikeda S; Takada S; Kikuchi A
Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability.
The Journal of biological chemistry 1999;274(16):10681-4.
1999: Matsubara K; Kishida S; Matsuura Y; Kitayama H; Noda M; Kikuchi A
Plasma membrane recruitment of RalGDS is critical for Ras-dependent Ral activation.
Oncogene 1999;18(6):1303-12.
1999: Kishida M; Koyama S; Kishida S; Matsubara K; Nakashima S; Higano K; Takada R; Takada S; Kikuchi A
Axin prevents Wnt-3a-induced accumulation of beta-catenin.
Oncogene 1999;18(4):979-85.
1999: Nieda M; Nicol A; Koezuka Y; Kikuchi A; Takahashi T; Nakamura H; Furukawa H; Yabe T; Ishikawa Y; Tadokoro K; Juji T
Activation of human Valpha24NKT cells by alpha-glycosylceramide in a CD1d-restricted and Valpha24TCR-mediated manner.
Human immunology 1999;60(1):10-9.
1998: Xu M J; Tsuji K; Ueda T; Mukouyama Y S; Hara T; Yang F C; Ebihara Y; Matsuoka S; Manabe A; Kikuchi A; Ito M; Miyajima A; Nakahata T
Stimulation of mouse and human primitive hematopoiesis by murine embryonic aorta-gonad-mesonephros-derived stromal cell lines.
Blood 1998;92(6):2032-40.
1998: Yamamoto H; Kishida S; Uochi T; Ikeda S; Koyama S; Asashima M; Kikuchi A
Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos.
Molecular and cellular biology 1998;18(5):2867-75.
1998: Kishida S; Yamamoto H; Ikeda S; Kishida M; Sakamoto I; Koyama S; Kikuchi A
Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin.
The Journal of biological chemistry 1998;273(18):10823-6.
1998: Shirouzu M; Morinaka K; Koyama S; Hu C D; Hori-Tamura N; Okada T; Kariya K; Kataoka T; Kikuchi A; Yokoyama S
Interactions of the amino acid residue at position 31 of the c-Ha-Ras protein with Raf-1 and RalGDS.
The Journal of biological chemistry 1998;273(13):7737-42.
1998: Ikeda S; Kishida S; Yamamoto H; Murai H; Koyama S; Kikuchi A
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.
The EMBO journal 1998;17(5):1371-84.
1998: Nieda M; Nicol A; Kikuchi A; Kashiwase K; Taylor K; Suzuki K; Tadokoro K; Juji T
Dendritic cells stimulate the expansion of bcr-abl specific CD8+ T cells with cytotoxic activity against leukemic cells from patients with chronic myeloid leukemia.
Blood 1998;91(3):977-83.
1998: Ikeda M; Ishida O; Hinoi T; Kishida S; Kikuchi A
Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral.
The Journal of biological chemistry 1998;273(2):814-21.
1997: Kishida S; Koyama S; Matsubara K; Kishida M; Matsuura Y; Kikuchi A
Colocalization of Ras and Ral on the membrane is required for Ras-dependent Ral activation through Ral GDP dissociation stimulator.
Oncogene 1997;15(24):2899-907.
1997: Nakajima T; Kimura M; Kuroda K; Tanaka M; Kikuchi A; Seino H; Yamao F; Oda K
Induction of ubiquitin conjugating enzyme activity for degradation of topoisomerase II alpha during adenovirus E1A-induced apoptosis.
Biochemical and biophysical research communications 1997;239(3):823-9.
1997: Matsubara K; Hinoi T; Koyama S; Kikuchi A
The post-translational modifications of Ral and Rac1 are important for the action of Ral-binding protein 1, a putative effector protein of Ral.
FEBS letters 1997;410(2-3):169-74.
1997: Murai H; Ikeda M; Kishida S; Ishida O; Okazaki-Kishida M; Matsuura Y; Kikuchi A
Characterization of Ral GDP dissociation stimulator-like (RGL) activities to regulate c-fos promoter and the GDP/GTP exchange of Ral.
The Journal of biological chemistry 1997;272(16):10483-90.
1997: Okazaki M; Kishida S; Hinoi T; Hasegawa T; Tamada M; Kataoka T; Kikuchi A
Synergistic activation of c-fos promoter activity by Raf and Ral GDP dissociation stimulator.
Oncogene 1997;14(5):515-21.
1996: Koyama S; Kishida S; Kikuchi A
[RalGDS mediates an intracellular signal-transduction system from a proto-oncogene product Ras]
Seikagaku. The Journal of Japanese Biochemical Society 1996;68(10):1646-50.
1996: Murai H; Okazaki M; Kikuchi A
Tyrosine dephosphorylation of glycogen synthase kinase-3 is involved in its extracellular signal-dependent inactivation.
FEBS letters 1996;392(2):153-60.
1996: Taki T; Ida K; Bessho F; Hanada R; Kikuchi A; Yamamoto K; Sako M; Tsuchida M; Seto M; Ueda R; Hayashi Y
Frequency and clinical significance of the MLL gene rearrangements in infant acute leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1996;10(8):1303-7.
1996: Hinoi T; Kishida S; Koyama S; Ikeda M; Matsuura Y; Kikuchi A
Post-translational modifications of Ras and Ral are important for the action of Ral GDP dissociation stimulator.
The Journal of biological chemistry 1996;271(33):19710-6.
1996: Okazaki M; Kishida S; Murai H; Hinoi T; Kikuchi A
Ras-interacting domain of Ral GDP dissociation stimulator like (RGL) reverses v-Ras-induced transformation and Raf-1 activation in NIH3T3 cells.
Cancer research 1996;56(10):2387-92.
1996: Akasaka K; Tamada M; Wang F; Kariya K; Shima F; Kikuchi A; Yamamoto M; Shirouzu M; Yokoyama S; Kataoka T
Differential structural requirements for interaction of Ras protein with its distinct downstream effectors.
The Journal of biological chemistry 1996;271(10):5353-60.
1996: Koyama S; Chen Y W; Ikeda M; Muslin A J; Williams L T; Kikuchi A
Ras-interacting domain of RGL blocks Ras-dependent signal transduction in Xenopus oocytes.
FEBS letters 1996;380(1-2):113-7.
1995: Ikeda M; Koyama S; Okazaki M; Dohi K; Kikuchi A
rap1 p21 regulates the interaction of ras p21 with RGL, a new effector protein of ras p21.
FEBS letters 1995;375(1-2):37-40.
1995: Koyama S; Williams L T; Kikuchi A
Characterization of the interaction of Raf-1 with ras p21 or 14-3-3 protein in intact cells.
FEBS letters 1995;368(2):321-5.
1995: Kawamura M; Kikuchi A; Kobayashi S; Hanada R; Yamamoto K; Horibe K; Shikano T; Ueda K; Hayashi K; Sekiya T
Mutations of the p53 and ras genes in childhood t(1;19)-acute lymphoblastic leukemia.
Blood 1995;85(9):2546-52.
1995: Kikuchi A; Nakanishi H; Takai Y
Purification and properties of Rab3A.
Methods in enzymology 1995;257():57-70.
1994: Hayashi Y; Kikuchi A; Kobayashi S; Shikano T; Hanada R; Yamamoto K; Sotomatsu M; Ishimoto K; Sako M; Yamamori S
[A study of E2A gene in childhood acute lymphoblastic leukemia]
[Rinsho ketsueki] The Japanese journal of clinical hematology 1994;35(1):9-13.
1994: Takai Y; Kaibuchi K; Kikuchi A; Sasaki T; Shirataki H; Tanaka K
Function and mode of action of small G protein.
Progress in clinical and biological research 1994;390():99-113.
1993: Takaishi K; Kikuchi A; Kuroda S; Kotani K; Sasaki T; Takai Y
Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility.
Molecular and cellular biology 1993;13(1):72-9.
1993: Miura Y; Kikuchi A; Musha T; Kuroda S; Yaku H; Sasaki T; Takai Y
Regulation of morphology by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in Swiss 3T3 cells.
The Journal of biological chemistry 1993;268(1):510-5.
1993: Takai Y; Kaibuchi K; Kikuchi A; Sasaki T; Shirataki H
Regulators of small GTPases.
Ciba Foundation symposium 1993;176():128-38; discussion 138-46.
1992: Kotani K; Kikuchi A; Doi K; Kishida S; Sakoda T; Kishi K; Takai Y
The functional domain of the stimulatory GDP/GTP exchange protein (smg GDS) which interacts with the C-terminal geranylgeranylated region of rap1/Krev-1/smg p21.
Oncogene 1992;7(9):1699-704.
1992: Kikuchi A
[Small GTP-binding proteins--mode of activation and function]
Seikagaku. The Journal of Japanese Biochemical Society 1992;64(9):1079-102.
1992: Yoshida Y; Kawata M; Miura Y; Musha T; Sasaki T; Kikuchi A; Takai Y
Microinjection of smg/rap1/Krev-1 p21 into Swiss 3T3 cells induces DNA synthesis and morphological changes.
Molecular and cellular biology 1992;12(8):3407-14.
1992: Kikuchi A; Kuroda S; Sasaki T; Kotani K; Hirata K; Katayama M; Takai Y
Functional interactions of stimulatory and inhibitory GDP/GTP exchange proteins and their common substrate small GTP-binding protein.
The Journal of biological chemistry 1992;267(21):14611-5.
1992: Kuroda S; Kikuchi A; Hirata K; Masuda T; Kishi K; Sasaki T; Takai Y
Cooperative function of rho GDS and rho GDI to regulate rho p21 activation in smooth muscle.
Biochemical and biophysical research communications 1992;185(1):473-80.
1992: Hirata K; Kikuchi A; Sasaki T; Kuroda S; Kaibuchi K; Matsuura Y; Seki H; Saida K; Takai Y
Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction.
The Journal of biological chemistry 1992;267(13):8719-22.
1992: Sugai M; Hashimoto K; Kikuchi A; Inoue S; Okumura H; Matsumoto K; Goto Y; Ohgai H; Moriishi K; Syuto B
Epidermal cell differentiation inhibitor ADP-ribosylates small GTP-binding proteins and induces hyperplasia of epidermis.
The Journal of biological chemistry 1992;267(4):2600-4.
1992: Kikuchi A; Kaibuchi K; Hori Y; Nonaka H; Sakoda T; Kawamura M; Mizuno T; Takai Y
Molecular cloning of the human cDNA for a stimulatory GDP/GTP exchange protein for c-Ki-ras p21 and smg p21.
Oncogene 1992;7(2):289-93.
1992: Kim Y S; Kikuchi A; Takai Y
Effect of chlorpromazine on the smg GDS action.
Biochemical and biophysical research communications 1992;182(3):1446-53.
1992: Matsuda K; Sakamoto C; Nakano O; Konda Y; Matozaki T; Wada K; Kasuga M; Mizoguchi A; Kikuchi A; Takai Y
Distribution of smg p25A and smg p21s, ras p21-like guanine nucleotide-binding proteins, in the rat stomach.
The American journal of physiology 1992;262(1 Pt 1):G69-73.
1992: Kaibuchi K; Kikuchi A; Kawata M; Takai Y
The small G protein superfamily--possible functions and modes of action.
Journal of nutritional science and vitaminology 1992;Spec No():275-8.
1991: Hori Y; Kikuchi A; Isomura M; Katayama M; Miura Y; Fujioka H; Kaibuchi K; Takai Y
Post-translational modifications of the C-terminal region of the rho protein are important for its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins.
Oncogene 1991;6(4):515-22.
1991: Isomura M; Kikuchi A; Ohga N; Takai Y
Regulation of binding of rhoB p20 to membranes by its specific regulatory protein, GDP dissociation inhibitor.
Oncogene 1991;6(1):119-24.
1991: Takai Y; Kaibuchi K; Kikuchi A; Kawata M; Sasaki T; Yamamoto T
Transforming and c-fos promoter/enhancer-stimulating activities of a GDP/GTP exchange protein for small GTP-binding proteins.
Princess Takamatsu symposia 1991;22():197-204.
1990: Fukumoto Y; Kaibuchi K; Hori Y; Fujioka H; Araki S; Ueda T; Kikuchi A; Takai Y
Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins.
Oncogene 1990;5(9):1321-8.
1990: Takai Y; Kikuchi A; Kawata M; Yamamoto K; Hoshijima M
Purification, characterization, and possible functions of small molecular weight GTP-binding proteins.
American journal of hypertension 1990;3(8 Pt 2):220S-223S.
1990: Araki S; Kikuchi A; Hata Y; Isomura M; Takai Y
Regulation of reversible binding of smg p25A, a ras p21-like GTP-binding protein, to synaptic plasma membranes and vesicles by its specific regulatory protein, GDP dissociation inhibitor.
The Journal of biological chemistry 1990;265(22):13007-15.
1990: Yamamoto J; Kikuchi A; Ueda T; Ohga N; Takai Y
A GTPase-activating protein for rhoB p20, a ras p21-like GTP-binding protein--partial purification, characterization and subcellular distribution in rat brain.
Brain research. Molecular brain research 1990;8(2):105-11.
1990: Mizoguchi A; Kim S; Ueda T; Kikuchi A; Yorifuji H; Hirokawa N; Takai Y
Localization and subcellular distribution of smg p25A, a ras p21-like GTP-binding protein, in rat brain.
The Journal of biological chemistry 1990;265(20):11872-9.
1990: Ueda T; Kikuchi A; Ohga N; Yamamoto J; Takai Y
Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein.
The Journal of biological chemistry 1990;265(16):9373-80.
1990: Kim S; Mizoguchi A; Kikuchi A; Takai Y
Tissue and subcellular distributions of the smg-21/rap1/Krev-1 proteins which are partly distinct from those of c-ras p21s.
Molecular and cellular biology 1990;10(6):2645-52.
1990: Hata Y; Kikuchi A; Sasaki T; Schaber M D; Gibbs J B; Takai Y
Inhibition of the ras p21 GTPase-activating protein-stimulated GTPase activity of c-Ha-ras p21 by smg p21 having the same putative effector domain as ras p21s.
The Journal of biological chemistry 1990;265(13):7104-7.
1990: Fujioka H; Kikuchi A; Yoshida Y; Kuroda S; Takai Y
A small GTP-binding protein (G protein) recognized by smg p25A GDP dissociation inhibitor (GDI) in human platelet membranes and GDI for this small G protein in human platelet cytosol.
Biochemical and biophysical research communications 1990;168(3):1244-52.
1990: Sasaki T; Kikuchi A; Araki S; Hata Y; Isomura M; Kuroda S; Takai Y
Purification and characterization from bovine brain cytosol of a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to smg p25A, a ras p21-like GTP-binding protein.
The Journal of biological chemistry 1990;265(4):2333-7.
1990: Hoshijima M; Kondo J; Kikuchi A; Yamamoto K; Takai Y
Purification and characterization from bovine brain membranes of a GTP-binding protein with a Mr of 21,000, ADP-ribosylated by an ADP-ribosyltransferase contaminated in botulinum toxin type C1--identification as the rhoA gene product.
Brain research. Molecular brain research 1990;7(1):9-16.
1989: Yamamoto K; Tanimoto T; Kim S; Kikuchi A; Takai Y
Small molecular weight GTP-binding proteins and signal transduction.
Clinica chimica acta; international journal of clinical chemistry 1989;185(3):347-55.
1989: Kim S; Kikuchi A; Mizoguchi A; Takai Y
Intrasynaptosomal distribution of the ras, rho and smg-25A GTP-binding proteins in bovine brain.
Brain research. Molecular brain research 1989;6(2-3):167-76.
1989: Ohga N; Kikuchi A; Ueda T; Yamamoto J; Takai Y
Rabbit intestine contains a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein.
Biochemical and biophysical research communications 1989;163(3):1523-33.
1989: Kuroda S; Kikuchi A; Takai Y
Kinetic analysis of the binding of guanine nucleotides to bovine brain rhoB p20, a ras p21-like GTP-binding protein.
Biochemical and biophysical research communications 1989;163(2):674-81.
1989: Kawata M; Kikuchi A; Hoshijima M; Yamamoto K; Hashimoto E; Yamamura H; Takai Y
Phosphorylation of smg p21, a ras p21-like GTP-binding protein, by cyclic AMP-dependent protein kinase in a cell-free system and in response to prostaglandin E1 in intact human platelets.
The Journal of biological chemistry 1989;264(26):15688-95.
1989: Shoji I; Kikuchi A; Kuroda S; Takai Y
Kinetic analysis of the binding of guanine nucleotide to bovine brain smg p25A.
Biochemical and biophysical research communications 1989;162(1):273-81.
1989: Kikuchi A; Sasaki T; Araki S; Hata Y; Takai Y
Purification and characterization from bovine brain cytosol of two GTPase-activating proteins specific for smg p21, a GTP-binding protein having the same effector domain as c-ras p21s.
The Journal of biological chemistry 1989;264(16):9133-6.
1989: Ueda T; Kikuchi A; Ohga N; Yamamoto J; Takai Y
GTPase activating proteins for the smg-21 GTP-binding protein having the same effector domain as the ras proteins in human platelets.
Biochemical and biophysical research communications 1989;159(3):1411-9.
1989: Takai Y; Kikuchi A
[ras p21-like small MW GTP-binding proteins in transmembrane signaling]
Gan to kagaku ryoho. Cancer & chemotherapy 1989;16(3 Pt 2):499-508.
1989: Sano K; Kikuchi A; Matsui Y; Teranishi Y; Takai Y
Tissue-specific expression of a novel GTP-binding protein (smg p25A) mRNA and its increase by nerve growth factor and cyclic AMP in rat pheochromocytoma PC-12 cells.
Biochemical and biophysical research communications 1989;158(2):377-85.
1989: Ohmori T; Kikuchi A; Yamamoto K; Kim S; Takai Y
Small molecular weight GTP-binding proteins in human platelet membranes. Purification and characterization of a novel GTP-binding protein with a molecular weight of 22,000.
The Journal of biological chemistry 1989;264(3):1877-81.
1988: Ohmori T; Kikuchi A; Yamamoto K; Kawata M; Kondo J; Takai Y
Identification of a platelet Mr 22,000 GTP-binding protein as the novel smg-21 gene product having the same putative effector domain as the ras gene products.
Biochemical and biophysical research communications 1988;157(2):670-6.
1988: Hoshijima M; Kikuchi A; Kawata M; Ohmori T; Hashimoto E; Yamamura H; Takai Y
Phosphorylation by cyclic AMP-dependent protein kinase of a human platelet Mr 22,000 GTP-binding protein (smg p21) having the same putative effector domain as the ras gene products.
Biochemical and biophysical research communications 1988;157(3):851-60.
1988: Yamashita T; Yamamoto K; Kikuchi A; Kawata M; Kondo J; Hishida T; Teranishi Y; Shiku H; Takai Y
Purification and characterization of c-Ki-ras p21 from bovine brain crude membranes.
The Journal of biological chemistry 1988;263(32):17181-8.
1988: Kikuchi A; Yamamoto K; Fujita T; Takai Y
ADP-ribosylation of the bovine brain rho protein by botulinum toxin type C1.
The Journal of biological chemistry 1988;263(31):16303-8.
1988: Ikeda K; Kikuchi A; Takai Y
Small molecular weight GTP-binding proteins in human erythrocyte ghosts.
Biochemical and biophysical research communications 1988;156(2):889-97.
1988: Yamamoto K; Kim S; Kikuchi A; Takai Y
Multiple small molecular weight GTP-binding proteins in bovine brain cytosol. Purification and characterization of a 24KDa protein.
Biochemical and biophysical research communications 1988;155(3):1284-92.
1988: Matsui Y; Kikuchi A; Kondo J; Hishida T; Teranishi Y; Takai Y
Nucleotide and deduced amino acid sequences of a GTP-binding protein family with molecular weights of 25,000 from bovine brain.
The Journal of biological chemistry 1988;263(23):11071-4.
1988: Nakanishi H; Ohyanagi H; Takeyama Y; Onoyama H; Saitoh Y; Kikuchi A; Takai Y
Mode of inhibitory action of cholecystokinin in amylase release from isolated rat pancreatic acini--inhibition of secretory process post to protein kinase C-calcium ion systems.
Biochemical and biophysical research communications 1988;154(3):1314-22.
1988: Kikuchi A; Yamashita T; Kawata M; Yamamoto K; Ikeda K; Tanimoto T; Takai Y
Purification and characterization of a novel GTP-binding protein with a molecular weight of 24,000 from bovine brain membranes.
The Journal of biological chemistry 1988;263(6):2897-904.

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