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Hee-Doo Kim

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Nam-Jung Kim; Sun-Young Kim; Jin Hee Lee; Fu-Nan Li; Changjin Lim; Hyeung-geun Park; Seul-gi Park; Yanghui Park; Young-Ho Park; Song Seok Shin; Jin Kyu Choi; Sun Choi; Young Taek Han; Yeon-Su Jeong; Jong-Wha Jung; Dae-Duk Kim; Hee-Doo Kim; Kyeojin Kim; Byoung Young Woo; Hwayoung Yun; Young-Ger Suh
Heterocycle-linked phenylbenzyl amides as novel TRPV1 antagonists and their TRPV1 binding modes: constraint-induced enhancement of in vitro and in vivo activities.
Mijung Jang; Young-Ho Park; Chong Hyun Ryu; Hee-Doo Kim
Chain branching approach in structure modification of TRPV1 receptor antagonist MK056 and its analogs.
Myung-Hee Choi; Chong-Kyo Lee; Hee-Doo Kim
Design and synthesis of 3'-fluoropenciclovir analogues as antiviral agents.

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All Publications

2013: Nam-Jung Kim; Sun-Young Kim; Jin Hee Lee; Fu-Nan Li; Changjin Lim; Hyeung-geun Park; Seul-gi Park; Yanghui Park; Young-Ho Park; Song Seok Shin; Jin Kyu Choi; Sun Choi; Young Taek Han; Yeon-Su Jeong; Jong-Wha Jung; Dae-Duk Kim; Hee-Doo Kim; Kyeojin Kim; Byoung Young Woo; Hwayoung Yun; Young-Ger Suh
Heterocycle-linked phenylbenzyl amides as novel TRPV1 antagonists and their TRPV1 binding modes: constraint-induced enhancement of in vitro and in vivo activities.
Chemistry, an Asian journal 2013;8(2):400-9.
2012: Mijung Jang; Young-Ho Park; Chong Hyun Ryu; Hee-Doo Kim
Chain branching approach in structure modification of TRPV1 receptor antagonist MK056 and its analogs.
Archives of pharmacal research 2012;35(2):321-6.
2010: Myung-Hee Choi; Chong-Kyo Lee; Hee-Doo Kim
Design and synthesis of 3'-fluoropenciclovir analogues as antiviral agents.
Archives of pharmacal research 2010;33(2):197-202.
2010: Minsun Chang; Seol-Rin Park; Juhyun Kim; Mijung Jang; Jeong Hyun Park; Ji Eun Park; Hyeung-geun Park; Young-Ger Suh; Yeon Su Jeong; Young-Ho Park; Hee-Doo Kim
Silicon switch approach in TRPV1 antagonist MK-056 and its analogues.
Bioorganic & medicinal chemistry 2010;18(1):111-6.
2009: Fu-Nan Li; Nam-Jung Kim; Dong-Jo Chang; Jaebong Jang; Hannah Jang; Jong-Wha Jung; Kyung-Hoon Min; Yeon-Su Jeong; Sun-Young Kim; Young-Ho Park; Hee-Doo Kim; Hyeung-geun Park; Young-Ger Suh
Synthesis and structural optimization of multiple H-bonding region of diarylalkyl (thio)amides as novel TRPV1 antagonists.
Bioorganic & medicinal chemistry 2009;17(24):8149-60.
2009: Guo Hua Jin; Da Yeon Lee; Ye-Jin Cheon; Hyo Jin Gim; Do Hee Kim; Hee-Doo Kim; Jae-Ha Ryu; Raok Jeon
Synthesis of phenylisothiourea derivatives as inhibitors of NO production in LPS activated macrophages.
Bioorganic & medicinal chemistry letters 2009;19(11):3088-92.
2009: Fu-Nan Li; Nam-Jung Kim; Seung-Mann Paek; Do-Yeon Kwon; Kyung Hoon Min; Yeon-Su Jeong; Sun-Young Kim; Young-Ho Park; Hee-Doo Kim; Hyeung-geun Park; Young-Ger Suh
Design, synthesis, and biological evaluation of novel diarylalkyl amides as TRPV1 antagonists.
Bioorganic & medicinal chemistry 2009;17(10):3557-67.
2009: Jae Yeon Kim; Hyo Jin Lim; Da Yeon Lee; Ji Sun Kim; Do Hee Kim; Hwa Jin Lee; Hee-Doo Kim; Raok Jeon; Jae-Ha Ryu
In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii.
Bioorganic & medicinal chemistry letters 2009;19(3):937-40.
2009: Yoon-Jung Choi; Hwan Mook Kim; Hee-Doo Kim
Synthesis and cytotoxic activities of C-benzylated flavonoids.
Archives of pharmacal research 2009;32(1):59-63.
2008: Jeong Hoon Yoon; Hyo Jin Lim; Hwa Jin Lee; Hee-Doo Kim; Raok Jeon; Jae-Ha Ryu
Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium.
Bioorganic & medicinal chemistry letters 2008;18(6):2179-82.
2008: Lak Shin Jeong; Hyuk Woo Lee; Hea Ok Kim; Dilip K Tosh; Shantanu Pal; Won Jun Choi; Zhan-Guo Gao; Amit R Patel; Wanda Williams; Kenneth Alan Jacobson; Hee-Doo Kim
Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-N,N-dialkyluronamides as human A3 adenosine receptor antagonists.
Bioorganic & medicinal chemistry letters 2008;18(5):1612-6.
2007: Jung Wha Jung; Hee-Doo Kim
Stereoselective synthesis of (-)-hydroxyclemastine as a versatile intermediate for the H1 receptor antagonist clemastine.
Archives of pharmacal research 2007;30(12):1521-5.
2007: Hoo-Kyun Choi; Myung-Kwan Chun; Se Hee Lee; Mee Hee Jang; Hee-Doo Kim; Chun Sik Jung; Seaung Youl Oh
In vitro and in vivo study of poly(ethylene glycol) conjugated ketoprofen to extend the duration of action.
International journal of pharmaceutics 2007;341(1-2):50-7.
2006: Hwa Jin Lee; Ji Sun Kim; Joung Wha Yoon; Hee-Doo Kim; Jae-Ha Ryu
Suppression of inducible nitric oxide synthase expression by yakuchinones and their analogues.
Chemical & pharmaceutical bulletin 2006;54(3):377-9.
2006: Sung Hee Lee; Geom Seog Seo; Ji Yeong Kim; Xing Yu Jin; Hee-Doo Kim; Dong Hwan Sohn
Heme oxygenase 1 mediates anti-inflammatory effects of 2',4',6'-tris(methoxymethoxy) chalcone.
European journal of pharmacology 2006;532(1-2):178-86.
2005: Hyunjoo Lee; Hyoungsu Kim; Taehyun Yoon; Byungsook Kim; Sanghee Kim; Hee-Doo Kim; Deukjoon Kim
Novel "protecting group-dependent" alkylation-RCM strategy to medium-sized oxacycles: first total synthesis of --isoprelaurefucin.
The Journal of organic chemistry 2005;70(22):8723-9.
2005: Young-Ger Suh; Yong-Sil Lee; Kyung-Hoon Min; Ok-Hui Park; Jin-Kwan Kim; Ho-Sun Seung; Seung-Yong Seo; Bo-Young Lee; Yeon-Hee Nam; Kwang-Ok Lee; Hee-Doo Kim; Hyeung-geun Park; Jeewoo Lee; Uhtaek Oh; Ju-Ok Lim; Sang-Uk Kang; Min-Jung Kil; Jae-Yeon Koo; Song Seok Shin; Yung Hyup Joo; Jin Kwan Kim; Yeon Su Jeong; Sun-Young Kim; Young-Ho Park
Novel potent antagonists of transient receptor potential channel, vanilloid subfamily member 1: structure-activity relationship of 1,3-diarylalkyl thioureas possessing new vanilloid equivalents.
Journal of medicinal chemistry 2005;48(18):5823-36.
2005: Hyeung-geun Park; Ji-Yeon Choi; Mi-Hyun Kim; Sea-Hoon Choi; Mi-kyung Park; Jihye Lee; Young-Ger Suh; Hawon Cho; Uhtaek Oh; Hee-Doo Kim; Yung Hyup Joo; Song Seok Shin; Jin Kwan Kim; Yeon Su Jeong; Hyun-Ju Koh; Young-Ho Park; Sang-sup Jew
Biarylcarboxybenzamide derivatives as potent vanilloid receptor (VR1) antagonistic ligands.
Bioorganic & medicinal chemistry letters 2005;15(3):631-4.
2005: Hye-Young Choi; Hee-Doo Kim
Synthesis and conformational study of 2-trityloxymethyltetrahydrofurans as key intermediates for antiviral nucleosides.
Archives of pharmacal research 2005;28(1):16-21.
2004: Chong Hyun Ryu; Mi Jung Jang; Jeong Wha Jung; Ju-Hyun Park; Hye Young Choi; Young-Ger Suh; Uhtaek Oh; Hyeung-geun Park; Jeewoo Lee; Hyun-Ju Koh; Joo-Hyun Mo; Yung Hyup Joo; Young-Ho Park; Hee-Doo Kim
Chain-branched 1,3-dibenzylthioureas as vanilloid receptor 1 antagonists.
Bioorganic & medicinal chemistry letters 2004;14(7):1751-5.
2004: Hyeung-geun Park; Ji-Yeon Choi; Sea-Hoon Choi; Mi-kyung Park; Jihye Lee; Young-Ger Suh; Hawon Cho; Uhtaek Oh; Hee-Doo Kim; Yung Hyup Joo; Sun-Young Kim; Young-Ho Park; Yeon Su Jeong; Jin Kyu Choi; Jin Kwan Kim; Sang-sup Jew
N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands.
Bioorganic & medicinal chemistry letters 2004;14(7):1693-6.
2004: Hyeung-geun Park; Ji-yeon Choi; Sea-Hoon Choi; Mi-kyung Park; Jihye Lee; Young-Ger Suh; Hawon Cho; Uhtaek Oh; Jiyoun Lee; Sang-Uk Kang; Jeewoo Lee; Hee-Doo Kim; Young-Ho Park; Yeon Su Jeong; Jin Kyu Choi; Sang-sup Jew
N-4-Substituted-benzyl-N'-tert-butylbenzyl thioureas as vanilloid receptor ligands: investigation on the role of methanesulfonamido group in antagonistic activity.
Bioorganic & medicinal chemistry letters 2004;14(3):787-91.
2003: Young-Ger Suh; Yong-Sil Lee; Kyung-Hoon Min; Ok-Hui Park; Ho-Sun Seung; Hee-Doo Kim; Hyeung-geun Park; J- Yeon Choi; Jeewoo Lee; Sang-Wook Kang; Uhtaek Oh; Jae-yeon Koo; Yung Hyup Joo; Sun-Young Kim; Jin Kwan Kim; Young Ho Park
Novel non-vanilloid VR1 antagonist of high analgesic effects and its structural requirement for VR1 antagonistic effects.
Bioorganic & medicinal chemistry letters 2003;13(24):4389-93.
2003: Myung-Hee Choi; Hee-Doo Kim
Synthesis of novel carboacyclic nucleosides with vinyl bromide moiety as open-chain analogues of neplanocin A.
Archives of pharmacal research 2003;26(12):990-6.
2003: Myong Jung Kim; Hea Ok Kim; Hee-Doo Kim; Joong Hyup Kim; Lak Shin Jeong; Moon Woo Chun
Synthesis and biological evaluation of thymine nucleosides fused with 3',4'-tetrahydrofuran ring.
Bioorganic & medicinal chemistry letters 2003;13(20):3499-501.
2003: Eunjung Jeon; Hee-Doo Kim; Jin-Seok Kim
Pluronic-grafted poly-(L)-lysine as a new synthetic gene carrier.
Journal of biomedical materials research. Part A 2003;66(4):854-9.
2003: Jeewoo Lee; Jiyoun Lee; Myungshim Kang; Myoungyoup Shin; Ji-Min Kim; Sang-Uk Kang; Ju-Ok Lim; Hyun-Kyung Choi; Young-Ger Suh; Hyeung-geun Park; Uhtaek Oh; Hee-Doo Kim; Young-Ho Park; Hee-Jin Ha; Young-Ho Kim; Attila Toth; Yun Wang; Richard Tran; Larry V Pearce; Daniel J Lundberg; Peter M Blumberg
N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues: novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor.
Journal of medicinal chemistry 2003;46(14):3116-26.
2003: JungWha Yoon; HyeYoung Choi; Hyun Joo Lee; Chong Hyun Ryu; Hyeung-geun Park; Young-Ger Suh; Uhtaek Oh; Yeon Su Jeong; Jin Kyu Choi; Young-Ho Park; Hee-Doo Kim
Chain-branched acyclic phenethylthiocarbamates as vanilloid receptor antagonists.
Bioorganic & medicinal chemistry letters 2003;13(9):1549-52.
2003: Hyung Ryong Moon; Sung Hee Kwon; Jeong Ah Lee; Byul Nae Yoo; Hea Ok Kim; Moon Woo Chun; Hee-Doo Kim; Joong Hyup Kim; Lak Shin Jeong
Design, synthesis, and in vitro evaluation of APIO analogue of neplanocin A.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1475-7.
2003: Ju-Hyun Park; Myung-Hee Choi; Lak Shin Jeong; Moon Woo Chun; Hee-Doo Kim
Synthesis of [1'-fluoro-2',2'-bis-(hydroxymethyl)cyclopropylmethyl]purines as antiviral agents.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):955-7.
2003: Hea Ok Kim; Jae Gyu Park; Hyung Ryong Moon; Prashantha Gunaga; Moo Hong Lim; Moon Woo Chun; Kenneth Alan Jacobson; Hee-Doo Kim; Lak Shin Jeong
Design and synthesis of A3 adenosine receptor ligands, 2'-fluoro analogues of Cl-IB-MECA.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):927-30.
2003: Hea Ok Kim; Moo Hong Lim; Jae Gyu Park; Hyung Ryong Moon; Kenneth Alan Jacobson; Hee-Doo Kim; Moon Woo Chun; Lak Shin Jeong
Design and synthesis of A3 adenosine receptor ligands, 3'-fluoro analogues of Cl-IB-MECA.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):923-5.
2003: Lak Shin Jeong; Jae Gyu Park; Won Jun Choi; Hyung Ryong Moon; Kang Man Lee; Hea Ok Kim; Hee-Doo Kim; Moon Woo Chun; Hea-Young Park; Kilhyoun Kim; Yhun Y Sheen
Synthesis of halogenated 9-(dihydroxycyclopent-4'-enyl) adenines and their inhibitory activities against S-adenosylhomocysteine hydrolase.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):919-21.
2003: Moon Woo Chun; Myong Jung Kim; Hea Ok Kim; Hee-Doo Kim; Joong Hyup Kim; Hyung Ryong Moon; Lak Shin Jeong
Synthesis of 5-azacytidine nucleosides with rigid sugar moiety as potential antitumor agents.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):915-7.
2003: Moon Woo Chun; Myong Jung Kim; Hea Ok Kim; Hyung Ryong Moon; Hee-Doo Kim; Joong Hyup Kim; Lak Shin Jeong
Synthesis and biological evaluation of pyrimidine nucleosides fused with 3',4'-tetrahydrofuran ring.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):719-21.
2003: Ju-Hyun Park; Young Rang Lee; Moon Woo Chun; Lak Shin Jeong; Chong-Kyo Lee; Hee-Doo Kim
Synthesis of (Z)-(1-fluoro-2-hydroxymethylcyclopropylmethyl)purines.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):659-61.
2003: Lak Shin Jeong; Hyung Ryong Moon; Jae Gyu Park; Dae Hong Shin; Won Jun Choi; Kang Man Lee; Hea Ok Kim; Moon Woo Chun; Hee-Doo Kim; Joong Hyup Kim
Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-adenosylhomocysteine hydrolase.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):589-92.
2003: Hyeung-geun Park; Mi-kyung Park; Ji-yeon Choi; Sea-Hoon Choi; Jihye Lee; Boon-saeng Park; Myoung Goo Kim; Young-Ger Suh; Hawon Cho; Uhtaek Oh; Jeewoo Lee; Hee-Doo Kim; Young-Ho Park; Hyun-Ju Koh; Kyung Min Lim; Joo Hyun Moh; Sang-sup Jew
Synthesis of N,N',N"-trisubstituted thiourea derivatives and their antagonist effect on the vanilloid receptor.
Bioorganic & medicinal chemistry letters 2003;13(4):601-4.
2003: Hyeung geun Park; Mi kyung Park; Ji yeon Choi; Sea hoon Choi; Jeewoo Lee; Young ger Suh; Uhtaek Oh; Jihye Lee; Hee-Doo Kim; Young Ho Park; Yeon Su Jeong; Jin Kyu Choi; Sang-sup Jew
Synthesis of 2-substituted-pyrrolidinethiourea derivatives and their antagonist effect on vanilloid receptor.
Bioorganic & medicinal chemistry letters 2003;13(2):197-200.
2001: Moon Woo Chun; Mi-Jeong Kim; U H Jo; Joong Hyup Kim; Hee-Doo Kim; Lak Shin Jeong
Synthesis of novel D- and L-3'-deoxy-3'-C-hydroxymethyl nucleoside with exocyclic methylene as potential ribonucleotide reductase inhibitor.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):703-6.
2001: Moon Woo Chun; Mi-Jeong Kim; U H Jo; Joong Hyup Kim; Hee-Doo Kim; Lak Shin Jeong
Synthesis of novel 3'-deoxy-3'-C-hydroxymethyl nucleosides with conformationally rigid sugar moiety as potential antiviral agents.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):699-702.
2001: Myung-Hee Choi; Chong-Kyo Lee; Lak Shin Jeong; Moon Woo Chun; Hee-Doo Kim
Novel nucleosides with vinyl fluoride or vinyl bromide moiety as open-chain analogs of neplanocin A.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):681-4.
2001: Young Rang Lee; Ju-Hyun Park; Raok Jeon; Lak Shin Jeong; Moon Woo Chun; Hee-Doo Kim
Design and synthesis of novel fluorocyclopropanoid nucleosides.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):677-9.
2001: Lak Shin Jeong; Y H Kim; Hea Ok Kim; Su Jeong Yoo; Y H Park; S H Yeon; Moon Woo Chun; Hee-Doo Kim
Synthesis and antiviral activity of D- and L-2'-azido-2',3'-dideoxy-4'-thiopyrimidine and purine nucleosides.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):665-8.
2001: Lak Shin Jeong; Hyung Ryong Moon; JH Hong; Su Jeong Yoo; Won Jun Choi; Hea Ok Kim; H S Ahn; H W Baek; Moon Woo Chun; Hee-Doo Kim; Jeongmin Kim; J R Choi
Structure-activity relationships of apio nucleosides as potential antiviral agents.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):657-60.
1999: Moon Woo Chun; S P Choi; Mi-Jeong Kim; C J Bae; Hyung Ryong Moon; Hee-Doo Kim; Lak Shin Jeong
Synthesis and antiviral activities of 1,3-oxathiolanyl nucleosides with 5-hydroxymethyl substituent.
Nucleosides & nucleotides 1999;18(4-5):615-6.
1999: Lak Shin Jeong; Hyung Ryong Moon; Su Jeong Yoo; S N Lee; Hee-Doo Kim; Moon Woo Chun
Synthesis and antiviral activity of L-2'-deoxy-2'-up-fluoro-4'-thionucleosides.
Nucleosides & nucleotides 1999;18(4-5):571-2.
1998: Sang-sup Jew; D Lim; S K Seo; T G Nam; H Park; Hee-Doo Kim; C M Kim; M H Lee; H G Paik; M J Lee; Y H Jung
Regioselective ring opening of steroidal epoxide with hydrides: formation of C(2)- and C(3)-deoxyasiatic acid derivatives.
Archives of pharmacal research 1998;21(6):793-5.
1997: Myung-Hee Choi; Hee-Doo Kim
Synthesis and biological evaluation of 9-[2-fluoro-4-hydroxy-3-hydroxymethyl-2-butenyl]adenine and its related compounds as open-chain analogues of neplanocin A.
Archives of pharmacal research 1997;20(5):501-6.