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Hea Ok Kim

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Won Jun Choi; Hwa-Jin Chung; Chang H Ahn; Varughese Alexander; Girish Chandra; Hea Ok Kim; Jin-Hee Kim; Hyuk Woo Lee; Sang Kook Lee; Young B Lee; Mahesh S Majik; Akshata Nayak; Long Xuan Zhao; Lak Shin Jeong
Fluorocyclopentenyl-cytosine with broad spectrum and potent antitumor activity.
Hyuk Woo Lee; Soo Kyung Nam; Won Jun Choi; Hea Ok Kim; Lak Shin Jeong
Stereoselective synthesis of MLN4924, an inhibitor of NEDD8-activating enzyme.
Kang Man Lee; Won Jun Choi; Yoonji Lee; Hyun Joo Lee; Long Xuan Zhao; Hyuk Woo Lee; Jae Gyu Park; Hea Ok Kim; Kwang Yeon Hwang; Yong-Seok Heo; Sun Choi; Lak Shin Jeong
X-ray crystal structure and binding mode analysis of human S-adenosylhomocysteine hydrolase complexed with novel mechanism-based inhibitors, haloneplanocin A analogues.

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All Publications

2012: Won Jun Choi; Hwa-Jin Chung; Chang H Ahn; Varughese Alexander; Girish Chandra; Hea Ok Kim; Jin-Hee Kim; Hyuk Woo Lee; Sang Kook Lee; Young B Lee; Mahesh S Majik; Akshata Nayak; Long Xuan Zhao; Lak Shin Jeong
Fluorocyclopentenyl-cytosine with broad spectrum and potent antitumor activity.
Journal of medicinal chemistry 2012;55(9):4521-5.
2011: Hyuk Woo Lee; Soo Kyung Nam; Won Jun Choi; Hea Ok Kim; Lak Shin Jeong
Stereoselective synthesis of MLN4924, an inhibitor of NEDD8-activating enzyme.
The Journal of organic chemistry 2011;76(9):3557-61.
2011: Kang Man Lee; Won Jun Choi; Yoonji Lee; Hyun Joo Lee; Long Xuan Zhao; Hyuk Woo Lee; Jae Gyu Park; Hea Ok Kim; Kwang Yeon Hwang; Yong-Seok Heo; Sun Choi; Lak Shin Jeong
X-ray crystal structure and binding mode analysis of human S-adenosylhomocysteine hydrolase complexed with novel mechanism-based inhibitors, haloneplanocin A analogues.
Journal of medicinal chemistry 2011;54(4):930-8.
2010: Hyuk Woo Lee; Hea Ok Kim; Won Jun Choi; Sun Choi; Jin Hee Lee; Seul-gi Park; Lena Yoo; Kenneth Alan Jacobson; Lak Shin Jeong
Design, synthesis, and binding of homologated truncated 4'-thioadenosine derivatives at the human A3 adenosine receptors.
Bioorganic & medicinal chemistry 2010;18(19):7015-21.
2010: Won Jun Choi; Yu Min Kim; Hea Ok Kim; Hyuk Woo Lee; Dong-Eun Kim; Kwang-su Park; Youhoon Chong; Lak Shin Jeong
Synthesis and anti-hepatitis C virus (HCV) activity of 3'-C-substituted-methyl pyrimidine and purine nucleosides.
Bioorganic & medicinal chemistry 2010;18(13):4812-20.
2010: Varughese Alexander; Won Jun Choi; Jeongha Chun; Hea Ok Kim; Ji Hye Jeon; Dilip K Tosh; Hyuk Woo Lee; Girish Chandra; Jungwon Choi; Lak Shin Jeong
A new DNA building block, 4'-selenothymidine: synthesis and modification to 4'-seleno-AZT as a potential anti-HIV agent.
Organic letters 2010;12(10):2242-5.
2009: Won Jun Choi; Hyuk Woo Lee; Hea Ok Kim; Moshe Chinn; Zhan-Guo Gao; Amit Patel; Kenneth Alan Jacobson; Hyung Ryong Moon; Young Hoon Jung; Lak Shin Jeong
Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists.
Bioorganic & medicinal chemistry 2009;17(23):8003-11.
2009: Lak Shin Jeong; Dilip K Tosh; Won Jun Choi; Sang Kook Lee; You-Jin Kang; Sun Choi; Jin Hee Lee; Hankil Lee; Hyuk Woo Lee; Hea Ok Kim
Discovery of a new template for anticancer agents: 2'-deoxy-2'-fluoro-4'-selenoarabinofuranosyl-cytosine (2'-F-4'-seleno-ara-C).
Journal of medicinal chemistry 2009;52(17):5303-6.
2009: Shantanu Pal; Won Jun Choi; Seung Ah Choe; Cara L Heller; Zhan-Guo Gao; Moshe Chinn; Kenneth Alan Jacobson; Xiyan Hou; Sang Kook Lee; Hea Ok Kim; Lak Shin Jeong
Structure-activity relationships of truncated adenosine derivatives as highly potent and selective human A3 adenosine receptor antagonists.
Bioorganic & medicinal chemistry 2009;17(10):3733-8.
2008: Lak Shin Jeong; Yoo Na Choi; Dilip K Tosh; Won Jun Choi; Hea Ok Kim; Jungwon Choi
Design and synthesis of novel 2',3'-dideoxy-4'-selenonucleosides as potential antiviral agents.
Bioorganic & medicinal chemistry 2008;16(23):9891-7.
2008: Lak Shin Jeong; Shantanu Pal; Seung Ah Choe; Won Jun Choi; Kenneth Alan Jacobson; Zhan-Guo Gao; Athena M Klutz; Xiyan Hou; Hea Ok Kim; Hyuk Woo Lee; Sang Kook Lee; Dilip K Tosh; Hyung Ryong Moon
Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists.
Journal of medicinal chemistry 2008;51(20):6609-13.
2008: Dilip K Tosh; Won Jun Choi; Hea Ok Kim; Yoonji Lee; Shantanu Pal; Xiyan Hou; Jungwon Choi; Sun Choi; Lak Shin Jeong
Stereoselective synthesis and conformational study of novel 2',3'-Didehydro-2',3'-dideoxy-4'-selenonucleosides.
The Journal of organic chemistry 2008;73(11):4259-62.
2008: Moon Woo Chun; Sung Wook Choi; Tae Kyung Kang; Won Jun Choi; Hea Ok Kim; Zhan-Guo Gao; Kenneth Alan Jacobson; Lak Shin Jeong
Synthesis of 3'-acetamidoadenosine derivatives as potential A3 adenosine receptor agonists.
Nucleosides, nucleotides & nucleic acids 2008;27(4):408-20.
2008: Lak Shin Jeong; Hyuk Woo Lee; Hea Ok Kim; Dilip K Tosh; Shantanu Pal; Won Jun Choi; Zhan-Guo Gao; Amit R Patel; Wanda Williams; Kenneth Alan Jacobson; Hee-Doo Kim
Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-N,N-dialkyluronamides as human A3 adenosine receptor antagonists.
Bioorganic & medicinal chemistry letters 2008;18(5):1612-6.
2008: Lak Shin Jeong; Dilip K Tosh; Hea Ok Kim; Ting Wang; Xiyan Hou; Ho Seop Yun; Youngjoo Kwon; Sang Kook Lee; Jungwon Choi; Long Xuan Zhao
First synthesis of 4'-selenonucleosides showing unusual Southern conformation.
Organic letters 2008;10(2):209-12.
2008: Won Jun Choi; Hyuk Woo Lee; Xiyan Hou; Hea Ok Kim; Kenneth Alan Jacobson; Lak Shin Jeong
Synthesis of 2-chloro-N6-substituted-4'-thioadenosine-5'-N, N-dialkyluronamides as potent and selective A3 adenosine receptor antagonists.
Nucleic acids symposium series (2004) 2008;(52):645-6.
2008: Xiyan Hou; Shantanu Pal; Won Jun Choi; Hea Ok Kim; Amol Tipnis; Kenneth Alan Jacobson; Lak Shin Jeong
Design and synthesis of truncated 4'-thioadenosine derivatives as potent and selective A3 adenosine receptor antagonists.
Nucleic acids symposium series (2004) 2008;(52):641-2.
2007: Ting Wang; Hyun Joo Lee; Dilip K Tosh; Hea Ok Kim; Shantanu Pal; Sun Choi; Yoonji Lee; Hyung Ryong Moon; Long Xuan Zhao; Kang Man Lee; Lak Shin Jeong
Design, synthesis, and molecular modeling studies of 5'-deoxy-5'-ureidoadenosine: 5'-ureido group as multiple hydrogen bonding donor in the active site of S-adenosylhomocysteine hydrolase.
Bioorganic & medicinal chemistry letters 2007;17(16):4456-9.
2007: Lak Shin Jeong; Seung Ah Choe; Prashantha Gunaga; Hea Ok Kim; Hyuk Woo Lee; Sang Kook Lee; Dilip K Tosh; Amit Patel; Krishnan K Palaniappan; Zhan-Guo Gao; Kenneth Alan Jacobson; Hyung Ryong Moon
Discovery of a new nucleoside template for human A3 adenosine receptor ligands: D-4'-thioadenosine derivatives without 4'-hydroxymethyl group as highly potent and selective antagonists.
Journal of medicinal chemistry 2007;50(14):3159-62.
2007: Krishnan K Palaniappan; Zhan-Guo Gao; Andrei A Ivanov; Rebecca Greaves; Hayamitsu Adachi; Pedro Besada; Hea Ok Kim; Ae Yil Kim; Seung Ah Choe; Lak Shin Jeong; Kenneth Alan Jacobson
Probing the binding site of the A1 adenosine receptor reengineered for orthogonal recognition by tailored nucleosides.
Biochemistry 2007;46(25):7437-48.
2007: Moon Woo Chun; Hyuk Woo Lee; Jin-Hee Kim; Hea Ok Kim; Kang Man Lee; Shantanu Pal; Hyung Ryong Moon; Lak Shin Jeong
Stereoselective synthesis of homo-apioneplanocin A as potential inhibitor of S-adenosylhomocysteine hydrolase.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):729-32.
2007: Lak Shin Jeong; Byul Nae Yoo; Hea Ok Kim; Kang Man Lee; Hyung Ryong Moon
Synthesis and anti-HCV activity Of 2''-beta-hydroxymethylated nucleosides.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):725-8.
2007: Lak Shin Jeong; Jeong A Lee; Hyung Ryong Moon; Hea Ok Kim; Kang Man Lee; Hyun Joo Lee; Moon Woo Chun
Asymmetric synthesis of novel apio carbocyclic nucleoside analogues as potential antiviral and antitumor agent.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):721-4.
2007: Lak Shin Jeong; Seung Ah Choe; Ae Yil Kim; Hea Ok Kim; Zhan-Guo Gao; Kenneth Alan Jacobson; Moon Woo Chun; Hyung Ryong Moon
Synthesis of N6-substituted 3'-ureidoadenosine derivatives as highly potent agonists at the mutant A3 adenosine receptor.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):717-9.
2007: Lak Shin Jeong; Hyuk Woo Lee; Hea Ok Kim; Ji Young Jung; Prashantha Gunaga; Sang Kook Lee; Eun-Jin Lee; Moon Woo Chun; Zhan-Guo Gao; Kenneth Alan Jacobson; Hyung Ryong Moon
Design, synthesis, and anti-tumor activity of 4'-thionucleosides as potent and selective agonists at the human A3 adenosine receptor.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1565-8.
2007: Lak Shin Jeong; Jeong A Lee; Hea Ok Kim; Dilip K Tosh; Hyung Ryong Moon; Seung-Jin Lee; Kang Man Lee; Yhun Y Sheen; Moon Woo Chun
Asymmetric synthesis of cyclopropyl-fused 2'-C-methylcarbanucleosides as potential anti-HCV agents.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):1021-4.
2007: Lak Shin Jeong; Prashantha Gunaga; Hea Ok Kim; Dilip K Tosh; Hyuk Woo Lee; Seung Ah Choe; Hyung Ryong Moon; Zhan-Guo Gao; Kenneth Alan Jacobson; Moon Woo Chun
Stereoselective synthesis of 1'-functionalized-4'-thionucleosides.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):1011-4.
2006: Jeong A Lee; Hea Ok Kim; Dilip K Tosh; Hyung Ryong Moon; Sanghee Kim; Lak Shin Jeong
Stereoselective synthesis of 2'-C-methyl-cyclopropyl-fused carbanucleosides as potential anti-HCV agents.
Organic letters 2006;8(22):5081-3.
2006: Prashantha Gunaga; Hea Ok Kim; Hyuk Woo Lee; Dilip K Tosh; Jae-Sang Ryu; Sun Choi; Lak Shin Jeong
Stereoselective functionalization of the 1'-position of 4'-thionucleosides.
Organic letters 2006;8(19):4267-70.
2006: Byul Nae Yoo; Hea Ok Kim; Hyung Ryong Moon; Su Kyung Seol; Sung Key Jang; Kang Man Lee; Lak Shin Jeong
Synthesis of 2-C-hydroxymethylribofuranosylpurines as potent anti-hepatitis C virus (HCV) agents.
Bioorganic & medicinal chemistry letters 2006;16(16):4190-4.
2006: Lak Shin Jeong; Hyuk Woo Lee; Hea Ok Kim; Ji Young Jung; Zhan-Guo Gao; Heng T Duong; Srikar Rao; Kenneth Alan Jacobson; Dae Hong Shin; Jeong A Lee; Prashantha Gunaga; Sang Kook Lee; Dong Zhe Jin; Moon Woo Chun; Hyung Ryong Moon
Design, synthesis, and biological activity of N6-substituted-4'-thioadenosines at the human A3 adenosine receptor.
Bioorganic & medicinal chemistry 2006;14(14):4718-30.
2006: Zhan-Guo Gao; Heng T Duong; Lak Shin Jeong; Ae Yil Kim; Hea Ok Kim; Myong Jung Kim; Soo-Kyung Kim; Bruce T Liang; Liaman Mamedova; Tatiana Sonina; Serge Van Calenbergh; Philippe Van Rompaey; Kenneth Alan Jacobson
Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists.
Journal of medicinal chemistry 2006;49(9):2689-702.
2006: Heekyoung Chung; Ji-Youn Jung; Sung-Dae Cho; Kyung-A Hong; Hyun-Jun Kim; Dong-Hui Shin; Hwan Kim; Hea Ok Kim; Dae Hong Shin; Hyuk Woo Lee; Lak Shin Jeong; Gu Kong
The antitumor effect of LJ-529, a novel agonist to A3 adenosine receptor, in both estrogen receptor-positive and estrogen receptor-negative human breast cancers.
Molecular cancer therapeutics 2006;5(3):685-92.
2006: Zhan-Guo Gao; Bhalchandra V Joshi; Athena M Klutz; Soo-Kyung Kim; Hyuk Woo Lee; Hea Ok Kim; Lak Shin Jeong; Kenneth Alan Jacobson
Conversion of A3 adenosine receptor agonists into selective antagonists by modification of the 5'-ribofuran-uronamide moiety.
Bioorganic & medicinal chemistry letters 2006;16(3):596-601.
2006: Lak Shin Jeong; Hyuk Woo Lee; Kenneth Alan Jacobson; Hea Ok Kim; Dae Hong Shin; Jeong A Lee; Zhan-Guo Gao; Changrui Lu; Heng T Duong; Prashantha Gunaga; Sang Kook Lee; Dong Zhe Jin; Moon Woo Chun; Hyung Ryong Moon
Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-uronamides as highly potent and selective agonists at the human A3 adenosine receptor.
Journal of medicinal chemistry 2006;49(1):273-81.
2005: Jeong A Lee; Hyung Ryong Moon; Hea Ok Kim; Kyung Ran Kim; Kang Man Lee; Bum Tae Kim; Ki Jun Hwang; Moon Woo Chun; Kenneth Alan Jacobson; Lak Shin Jeong
Synthesis of novel apio carbocyclic nucleoside analogues as selective a(3) adenosine receptor agonists.
The Journal of organic chemistry 2005;70(13):5006-13.
2005: Long Xuan Zhao; Mikyung Yun; Hea Ok Kim; Jeong A Lee; Won Jun Choi; Kang Man Lee; Sang Kook Lee; Young B Lee; Chang Ho Ahn; Lak Shin Jeong
Design, synthesis, and anticancer activity of fluorocyclopentenyl-pyrimidines.
Nucleic acids symposium series (2004) 2005;(49):107-8.
2005: Ae Yil Kim; Hea Ok Kim; Myoung Jung Kim; Moon Woo Chun; Kang Man Lee; Kenneth Alan Jacobson; Lak Shin Jeong
Synthesis of 3'-ureidoadenosines and their high binding affinity at the mutant A3 adenosine receptor.
Nucleic acids symposium series (2004) 2005;(49):105-6.
2005: Moon Woo Chun; Hyouk Woo Lee; Ae Yil Kim; Myong Jung Kim; Hea Ok Kim; Zhan-Guo Gao; Kenneth Alan Jacobson; Lak Shin Jeong
Synthesis of 3'-ureidoadenosine analogues and their binding affinity to the A3 adenosine receptor.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):1119-21.
2005: Prashantha Gunaga; Hea Ok Kim; Hyun Ji Kim; Moon Woo Chun; Lak Shin Jeong
Stereoselective synthesis of novel thioiso dideoxy nucleosides with exocyclic methylene as potential antiviral agents.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):1115-7.
2005: Won Jun Choi; Hyung Ryong Moon; Hea Ok Kim; Young Mi Ko; Hye Jin Kim; Jeong A Lee; Kang Man Lee; Mi Kyung Yun; Dae Hong Shin; Moon Woo Chun; Yhun Y Sheen; Kilhyoun Kim; Lak Shin Jeong
Stereoselective synthesis of 3-hydroxymethyl-D-cyclopentenone, the versatile intermediate for the synthesis of carbocyclic nucleosides.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):611-3.
2005: Hyouk Woo Lee; Dae Hong Shin; Ji Young Jeong; Hea Ok Kim; Moon Woo Chun; Neli Melman; Zhan-Guo Gao; Kenneth Alan Jacobson; Lak Shin Jeong
D-4'-thioadenosine derivatives as highly potent and selective agonists at the human A3 adenosine receptor.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):607-9.
2004: Hyung Ryong Moon; Hyun Joo Lee; Kyung Ran Kim; Kang Man Lee; Sang Kook Lee; Hea Ok Kim; Moon Woo Chun; Lak Shin Jeong
Synthesis of 5'-substituted fluoro-neplanocin A analogues: importance of a hydrogen bonding donor at 5'-position for the inhibitory activity of S-adenosylhomocysteine hydrolase.
Bioorganic & medicinal chemistry letters 2004;14(22):5641-4.
2004: Lak Shin Jeong; Myong Jung Kim; Hea Ok Kim; Zhan-Guo Gao; Soo-Kyung Kim; Kenneth Alan Jacobson; Moon Woo Chun
Design and synthesis of 3'-ureidoadenosine-5'-uronamides: effects of the 3'-ureido group on binding to the A3 adenosine receptor.
Bioorganic & medicinal chemistry letters 2004;14(19):4851-4.
2004: Hea Ok Kim; Su Jeong Yoo; Hee Sung Ahn; Won Jun Choi; Hyung Ryong Moon; Kang Man Lee; Moon Woo Chun; Lak Shin Jeong
Synthesis of fluorinated cyclopentenyladenine as potent inhibitor of S-adenosylhomocysteine hydrolase.
Bioorganic & medicinal chemistry letters 2004;14(9):2091-3.
2004: Hea Ok Kim; Hye Won Baek; Hyung Ryong Moon; Dae-Kee Kim; Moon Woo Chun; Lak Shin Jeong
Synthesis and biological evaluation of novel tert-azido or tert-amino substituted penciclovir analogs.
Organic & biomolecular chemistry 2004;2(8):1164-8.
2004: Won Jun Choi; Hyung Ryong Moon; Hea Ok Kim; Byul Nae Yoo; Jeong A Lee; Dae Hong Shin; Lak Shin Jeong
Preparative and stereoselective synthesis of the versatile intermediate for carbocyclic nucleosides: effects of the bulky protecting groups to enforce facial selectivity.
The Journal of organic chemistry 2004;69(7):2634-6.
2004: Zhan-Guo Gao; Lak Shin Jeong; Hyung Ryong Moon; Hea Ok Kim; Won Jun Choi; Dae Hong Shin; Eleonora Elhalem; Maria J Comin; Neli Melman; Liaman Mamedova; Ariel S Gross; Juan B Rodriguez; Kenneth Alan Jacobson
Structural determinants of efficacy at A3 adenosine receptors: modification of the ribose moiety.
Biochemical pharmacology 2004;67(5):893-901.
2004: Dong Zhe Jin; Sung Hee Kwon; Hyung Ryong Moon; Prashantha Gunaga; Hea Ok Kim; Dae-Kee Kim; Moon Woo Chun; Lak Shin Jeong
Synthesis of D- and L-apio nucleoside analogues with 2'-hydroxyl group as potential anti-HIV agents.
Bioorganic & medicinal chemistry 2004;12(5):1101-9.
2003: Hak-Sung Kim; Michihiro Ohno; Bin Xu; Hea Ok Kim; Yongseok Choi; Xiao-Duo Ji; Savitri Maddileti; Victor E Marquez; T Kendall Harden; Kenneth Alan Jacobson
2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists.
Journal of medicinal chemistry 2003;46(23):4974-87.
2003: Myong Jung Kim; Hea Ok Kim; Hee-Doo Kim; Joong Hyup Kim; Lak Shin Jeong; Moon Woo Chun
Synthesis and biological evaluation of thymine nucleosides fused with 3',4'-tetrahydrofuran ring.
Bioorganic & medicinal chemistry letters 2003;13(20):3499-501.
2003: Lak Shin Jeong; Dong Zhe Jin; Hea Ok Kim; Dae Hong Shin; Hyung Ryong Moon; Prashantha Gunaga; Moon Woo Chun; Yong-Chul Kim; Neli Melman; Zhan-Guo Gao; Kenneth Alan Jacobson
N6-substituted D-4'-thioadenosine-5'-methyluronamides: potent and selective agonists at the human A3 adenosine receptor.
Journal of medicinal chemistry 2003;46(18):3775-7.
2003: Hyung Ryong Moon; Sung Hee Kwon; Jeong Ah Lee; Byul Nae Yoo; Hea Ok Kim; Moon Woo Chun; Hee-Doo Kim; Joong Hyup Kim; Lak Shin Jeong
Design, synthesis, and in vitro evaluation of APIO analogue of neplanocin A.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1475-7.
2003: Hea Ok Kim; Jae Gyu Park; Hyung Ryong Moon; Prashantha Gunaga; Moo Hong Lim; Moon Woo Chun; Kenneth Alan Jacobson; Hee-Doo Kim; Lak Shin Jeong
Design and synthesis of A3 adenosine receptor ligands, 2'-fluoro analogues of Cl-IB-MECA.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):927-30.
2003: Hea Ok Kim; Moo Hong Lim; Jae Gyu Park; Hyung Ryong Moon; Kenneth Alan Jacobson; Hee-Doo Kim; Moon Woo Chun; Lak Shin Jeong
Design and synthesis of A3 adenosine receptor ligands, 3'-fluoro analogues of Cl-IB-MECA.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):923-5.
2003: Lak Shin Jeong; Jae Gyu Park; Won Jun Choi; Hyung Ryong Moon; Kang Man Lee; Hea Ok Kim; Hee-Doo Kim; Moon Woo Chun; Hea-Young Park; Kilhyoun Kim; Yhun Y Sheen
Synthesis of halogenated 9-(dihydroxycyclopent-4'-enyl) adenines and their inhibitory activities against S-adenosylhomocysteine hydrolase.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):919-21.
2003: Moon Woo Chun; Myong Jung Kim; Hea Ok Kim; Hee-Doo Kim; Joong Hyup Kim; Hyung Ryong Moon; Lak Shin Jeong
Synthesis of 5-azacytidine nucleosides with rigid sugar moiety as potential antitumor agents.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):915-7.
2003: Moon Woo Chun; Myong Jung Kim; Hea Ok Kim; Hyung Ryong Moon; Hee-Doo Kim; Joong Hyup Kim; Lak Shin Jeong
Synthesis and biological evaluation of pyrimidine nucleosides fused with 3',4'-tetrahydrofuran ring.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):719-21.
2003: Lak Shin Jeong; Hyung Ryong Moon; Jae Gyu Park; Dae Hong Shin; Won Jun Choi; Kang Man Lee; Hea Ok Kim; Moon Woo Chun; Hee-Doo Kim; Joong Hyup Kim
Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-adenosylhomocysteine hydrolase.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):589-92.
2003: Jeewoo Lee; Sung Eun Kim; Ji Young Lee; Su Yeon Kim; Sang Uk Kang; Seung Hwan Seo; Moon Woo Chun; Taehee Kang; Soo Young Choi; Hea Ok Kim
N-Alkoxysulfamide, N-hydroxysulfamide, and sulfamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases.
Bioorganic & medicinal chemistry letters 2003;13(6):1087-92.
2003: Moo Hong Lim; Hea Ok Kim; Hyung Ryong Moon; Seung Jin Lee; Moon Woo Chun; Zhan-Guo Gao; Neli Melman; Kenneth Alan Jacobson; Joong Hyup Kim; Lak Shin Jeong
Design, synthesis and binding affinity of 3'-fluoro analogues of Cl-IB-MECA as adenosine A3 receptor ligands.
Bioorganic & medicinal chemistry letters 2003;13(5):817-20.
2003: Lak Shin Jeong; Su Jeong Yoo; Kang Man Lee; Mi Jeong Koo; Won Jun Choi; Hea Ok Kim; Hyung Ryong Moon; Min Young Lee; Jae Gyu Park; Sang Kook Lee; Moon Woo Chun
Design, synthesis, and biological evaluation of fluoroneplanocin A as the novel mechanism-based inhibitor of S-adenosylhomocysteine hydrolase.
Journal of medicinal chemistry 2003;46(2):201-3.
2003: Moon Woo Chun; Moo Hong Lim; Hyung Ryong Moon; Hea Ok Kim; Kenneth Alan Jacobson; Lak Shin Jeong
Synthesis of 3'-fluoro analogue of Cl-IB-MECA as adenosine A3 receptor ligand.
Nucleic acids research. Supplement (2001) 2003;(3):19-20.
2002: Hyung Ryong Moon; Hea Ok Kim; Kang Man Lee; Moon Woo Chun; Joong Hyup Kim; Lak Shin Jeong
Stereoselective synthesis of a novel apio analogue of neplanocin A as potential S-adenosylhomocysteine hydrolase inhibitor.
Organic letters 2002;4(20):3501-3.
2002: Hea Ok Kim; Yong Hee Park; Hyung Ryong Moon; Lak Shin Jeong
Synthesis and biological evaluation of novel D-2'-azido-2',3'-dideoxyarabinofuranosyl-4'-thiopyrimidines and purines.
Bioorganic & medicinal chemistry letters 2002;12(17):2403-6.
2002: Hyung Ryong Moon; Hea Ok Kim; Sang Kook Lee; Won Jun Choi; Moon Woo Chun; Lak Shin Jeong
Synthesis and biological evaluation of novel thioapio dideoxynucleosides.
Bioorganic & medicinal chemistry 2002;10(5):1499-507.
2002: Moo Hong Lim; Hea Ok Kim; Hyung Ryong Moon; Moon Woo Chun; Lak Shin Jeong
Synthesis of novel D-2'-deoxy-2'-C-difluoromethylene-4'-thiocytidine as a potential antitumor agent.
Organic letters 2002;4(4):529-31.
2002: Si-Nae Park; Jong-Chul Park; Hea Ok Kim; Min Jung Song; Hwal Suh
Characterization of porous collagen/hyaluronic acid scaffold modified by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide cross-linking.
Biomaterials 2002;23(4):1205-12.
2002: Su Jeong Yoo; Hea Ok Kim; Yoongho Lim; Jeongmin Kim; Lak Shin Jeong
Synthesis of novel (2R,4R)- and (2S,4S)-iso dideoxynucleosides with exocyclic methylene as potential antiviral agents.
Bioorganic & medicinal chemistry 2002;10(1):215-26.
2001: Hea Ok Kim
Synthesis of 2-alkyl-substituted-N6-methyladenine derivatives as potential adenosine receptor ligand.
Archives of pharmacal research 2001;24(6):508-13.
2001: Won Jun Choi; Jae Gyu Park; Su Jeong Yoo; Hea Ok Kim; Hyung Ryong Moon; Moon Woo Chun; Y H Jung; Lak Shin Jeong
Syntheses of D- and L-cyclopentenone derivatives using ring-closing metathesis: versatile intermediates for the synthesis of D- and L-carbocyclic nucleosides.
The Journal of organic chemistry 2001;66(19):6490-4.
2001: Lak Shin Jeong; Y H Kim; Hea Ok Kim; Su Jeong Yoo; Y H Park; S H Yeon; Moon Woo Chun; Hee-Doo Kim
Synthesis and antiviral activity of D- and L-2'-azido-2',3'-dideoxy-4'-thiopyrimidine and purine nucleosides.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):665-8.
2001: Lak Shin Jeong; Hyung Ryong Moon; JH Hong; Su Jeong Yoo; Won Jun Choi; Hea Ok Kim; H S Ahn; H W Baek; Moon Woo Chun; Hee-Doo Kim; Jeongmin Kim; J R Choi
Structure-activity relationships of apio nucleosides as potential antiviral agents.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):657-60.
2001: JH Hong; Hea Ok Kim; Hyung Ryong Moon; Lak Shin Jeong
Synthesis and antiviral activity of fluoro-substituted apio dideoxynucleosides.
Archives of pharmacal research 2001;24(2):95-9.
2001: Lak Shin Jeong; Hea Ok Kim; Hyung Ryong Moon; JH Hong; Su Jeong Yoo; Won Jun Choi; Moon Woo Chun; C K Lee
Syntheses and structure--activity relationships of novel apio and thioapio dideoxydidehydronucleosides as anti-HCMV agents.
Journal of medicinal chemistry 2001;44(5):806-13.
2000: Nandanan Erathodiyil; SY Jang; Stefano Moro; Hea Ok Kim; M A Siddiqui; P Russ; Victor E Marquez; R Busson; Piet Herdewijn; T Kendall Harden; José L Boyer; Kenneth Alan Jacobson
Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands.
Journal of medicinal chemistry 2000;43(5):829-42.
1998: Lak Shin Jeong; J E Lee; Hea Ok Kim; Moon Woo Chun
Synthesis and antiviral activity of 2'-fluorohexopyranosyl nucleosides.
Archives of pharmacal research 1998;21(3):338-43.