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George Baillie

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Apostolos Zarros; Ryan T Cameron; Stylianos Tsakiris; George S Baillie
Evaluating the suitability of postnuclear supernatants as in vitro models for assessing cadmium- and other xenobiotic-induced neurotoxicity on crucial enzymatic parameters.
Ryan T Cameron; Ryan G Coleman; Jon P Day; Miles D Houslay; Brian K Shoichet; Krishna C Yalla; David R Adams; George S Baillie
Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4).
Kim M Brown; Frank Christian; Shireen A Davies; Jon P Day; Kornelia Hampel; Miles D Houslay; Elaine Huston; Walter Kolch; Louisa C Y Lee; David B Morton; David Romano; Masami Shimizu-Albergine; Selim Terhzaz; Miranda J Willis; Bastian Zimmermann; Joseph A Beavo; George S Baillie
Phosphodiesterase-8A binds to and regulates Raf-1 kinase.

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2013: Apostolos Zarros; Ryan T Cameron; Stylianos Tsakiris; George S Baillie
Evaluating the suitability of postnuclear supernatants as in vitro models for assessing cadmium- and other xenobiotic-induced neurotoxicity on crucial enzymatic parameters.
Biological trace element research 2013;152(3):297-9.
2013: Ryan T Cameron; Ryan G Coleman; Jon P Day; Miles D Houslay; Brian K Shoichet; Krishna C Yalla; David R Adams; George S Baillie
Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4).
Biochemical pharmacology 2013;85(9):1297-305.
2013: Kim M Brown; Frank Christian; Shireen A Davies; Jon P Day; Kornelia Hampel; Miles D Houslay; Elaine Huston; Walter Kolch; Louisa C Y Lee; David B Morton; David Romano; Masami Shimizu-Albergine; Selim Terhzaz; Miranda J Willis; Bastian Zimmermann; Joseph A Beavo; George S Baillie
Phosphodiesterase-8A binds to and regulates Raf-1 kinase.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(16):E1533-42.
2013: Louisa C Y Lee; Donald H Maurice; George S Baillie
Targeting protein-protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease.
Future medicinal chemistry 2013;5(4):451-64.
2012: Helen V Edwards; John D Scott; George S Baillie
The A-kinase-anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser(16).
The Biochemical journal 2012;446(3):437-43.
2012: Kim M Brown; Jonathan P Day; Jane E Findlay; Louisa C Y Lee; George S Baillie
Cyclic AMP-specific phosphodiesterase, PDE8A1, is activated by protein kinase A-mediated phosphorylation.
FEBS letters 2012;586(11):1631-7.
2012: Helen V Edwards; Frank Christian; George S Baillie
cAMP: novel concepts in compartmentalised signalling.
Seminars in cell & developmental biology 2012;23(2):181-90.
2012: Yuan Yan Sin; George S Baillie
Protein kinase D in the hypertrophy pathway.
Biochemical Society transactions 2012;40(1):287-9.
2012: Helen V Edwards; John D Scott; George S Baillie
PKA phosphorylation of the small heat-shock protein Hsp20 enhances its cardioprotective effects.
Biochemical Society transactions 2012;40(1):210-4.
2011: Evelyne Lima-Fernandes; Stefano Marullo; Julie A Pitcher; Lamia Achour; George S Baillie; Alexandre Benmerah; Cedric Boularan; Emeline Camand; Eric Chastre; hervé enslen; Sandrine Etienne-Manneville; Lucien C D Gibson; Larissa Kotelevets; Mark G H Scott
Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestins.
The EMBO journal 2011;30(13):2557-68.
2011: Jonathan P Day; Barbara Lindsay; Tracy Riddell; Zhong Jiang; Robert W Allcock; Achamma Abraham; Sebastian Sookup; Frank Christian; Jana Bogum; Elisabeth K Martin; Robert L Rae; Diana Anthony; Georgina M Rosair; Daniel M Houslay; Elaine Huston; George S Baillie; Enno Klussmann; Miles D Houslay; David R Adams
Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4).
Journal of medicinal chemistry 2011;54(9):3331-47.
2011: Y Y Sin; H V Edwards; Xiang Li; Jonathan P Day; F Christian; Allan J Dunlop; David R Adams; Manuela Zaccolo; Miles D Houslay; George S Baillie
Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes.
Journal of molecular and cellular cardiology 2011;50(5):872-83.
2011: Kirsty F MacKenzie; Derek A Wallace; Elaine V Hill; Diana F Anthony; David J P Henderson; Daniel M Houslay; J Simon C Arthur; George S Baillie; Miles D Houslay
Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation.
The Biochemical journal 2011;435(3):755-69.
2011: Martin A M Reijns; Doryen Bubeck; Lucien C D Gibson; Stephen C Graham; George S Baillie; E Yvonne Jones; Andrew P Jackson
The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease.
The Journal of biological chemistry 2011;286(12):10530-9.
2011: D F Anthony; Y Y Sin; S Vadrevu; N Advant; J P Day; A M Byrne; M J Lynch; Graeme Milligan; Miles D Houslay; George S Baillie
β-Arrestin 1 inhibits the GTPase-activating protein function of ARHGAP21, promoting activation of RhoA following angiotensin II type 1A receptor stimulation.
Molecular and cellular biology 2011;31(5):1066-75.
2010: Peter Burton; David R Adams; Achamma Abraham; Robert W Allcock; Zhong Jiang; Angela McCahill; Jane Gilmour; John McAbney; Alexandra Kaupisch; Nicole Kane; George S Baillie; Andrew H Baker; Graeme Milligan; Miles D Houslay; joanne mountford
Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells.
The Biochemical journal 2010;432(3):575-84.
2010: Rebecca J Bird; George S Baillie; Stephen J Yarwood
Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C.
The Biochemical journal 2010;432(1):207-16.
2010: Frank Christian; Diana F Anthony; Surakiran Vadrevu; Tracy Riddell; Jonathan P Day; Ruth McLeod; David R Adams; George S Baillie; Miles D Houslay
p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways.
Cellular signalling 2010;22(10):1576-96.
2010: Peter Burton; David R Adams; Achamma Abraham; Robert W Allcock; Zhong Jiang; Angela McCahill; Jane Gilmour; John McAbney; Nicole Kane; George S Baillie; Fergus R McKenzie; Andrew H Baker; Miles D Houslay; joanne mountford; Graeme Milligan
Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells.
Biochemical Society transactions 2010;38(4):1058-61.
2010: Xiang Li; Suryakiran Vadrevu; Allan J Dunlop; Jon Day; Noopur Advant; Jessica Troeger; Enno Klussmann; Ellis Jaffrey; Ron Thomas Hay; David R Adams; Miles D Houslay; George S Baillie
Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK.
The Biochemical journal 2010;428(1):55-65.
2010: Elisa Bjørgo; Silje A Solheim; Hilde Abrahamsen; George S Baillie; Kim M Brown; Torunn Berge; Klaus Okkenhaug; Miles D Houslay; Kjetil Taskén
Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex.
Molecular and cellular biology 2010;30(7):1660-72.
2010: Tian-Rui Xu; Vladislav Vyshemirsky; Amélie Gormand; Alex von Kriegsheim; Mark Girolami; George S Baillie; Dominic Ketley; Allan J Dunlop; Graeme Milligan; Miles D Houslay; Walter Kolch
Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species.
Science signaling 2010;3(113):ra20.
2009: Xiang Li; Ruth MacLeod; Allan J Dunlop; Helen V Edwards; Noopur Advant; Lucien C D Gibson; Nicola M Devine; Kim M Brown; David R Adams; Miles D Houslay; George S Baillie
A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex.
FEBS letters 2009;583(20):3310-6.
2009: Xiang Li; George S Baillie; Miles D Houslay
Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5.
The Journal of biological chemistry 2009;284(24):16170-82.
2009: Dong Meng; Martin J Lynch; Elaine Huston; Michael Beyermann; Jenny Eichhorst; David R Adams; Enno Klussmann; Enno Klusmann; Miles D Houslay; George S Baillie
MEK1 binds directly to betaarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization.
The Journal of biological chemistry 2009;284(17):11425-35.
2009: George S Baillie
Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases.
The FEBS journal 2009;276(7):1790-9.
2008: Daniel M Collins; Hannah Murdoch; Allan J Dunlop; Erik Charych; George S Baillie; Qi Wang; Friedrich W Herberg; Nicholas Brandon; Anke Prinz; Miles D Houslay
Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA).
Cellular signalling 2008;20(12):2356-69.
2008: Angela McCahill; Lachlan Campbell; Theresa McSorley; Arvind Sood; Martin J Lynch; Xiang Li; Chen Yan; George S Baillie; Miles D Houslay
In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10).
Cellular signalling 2008;20(11):2071-83.
2008: Giulietta Di Benedetto; Anna Zoccarato; Valentina Lissandron; Anna Terrin; Xiang Li; Miles D Houslay; George S Baillie; Manuela Zaccolo
Protein kinase A type I and type II define distinct intracellular signaling compartments.
Circulation research 2008;103(8):836-44.
2008: Elaine Huston; Martin J Lynch; Ahmed Mohamed; Daniel M Collins; Elaine V Hill; Ruth MacLeod; Eberhard Krause; George S Baillie; Miles D Houslay
EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):12791-6.
2008: Tian-Rui Xu; George S Baillie; Narinder Bhari; Thomas M Houslay; Andrew M Pitt; David R Adams; Walter Kolch; Miles D Houslay; Graeme Milligan
Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAPKs: implications for beta2-adrenoceptor signalling via the ERK1/2 MAPKs.
The Biochemical journal 2008;413(1):51-60.
2008: Kirsty F Mackenzie; Emma C Topping; Bozena Bugaj-Gaweda; Chengjun Deng; York-Fong Cheung; Aileen E Olsen; Cecil R Stockard; Lisa High Mitchell; George S Baillie; William E Grizzle; Michael De Vivo; Miles D Houslay; Daguang Wang; Graeme B Bolger
Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change.
The Biochemical journal 2008;411(2):361-9.
2007: K John Smith; George S Baillie; Eva I Hyde; Xiang Li; Thomas M Houslay; Angela McCahill; Allan J Dunlop; Graeme B Bolger; Enno Klussmann; David R Adams; Miles D Houslay
1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1.
Cellular signalling 2007;19(12):2612-24.
2007: Debbie Willoughby; George S Baillie; Martin J Lynch; Antonio Ciruela; Miles D Houslay; dermot cooper
Dynamic regulation, desensitization, and cross-talk in discrete subcellular microdomains during beta2-adrenoceptor and prostanoid receptor cAMP signaling.
The Journal of biological chemistry 2007;282(47):34235-49.
2007: Martin J Lynch; George S Baillie; Miles D Houslay
cAMP-specific phosphodiesterase-4D5 (PDE4D5) provides a paradigm for understanding the unique non-redundant roles that PDE4 isoforms play in shaping compartmentalized cAMP cell signalling.
Biochemical Society transactions 2007;35(Pt 5):938-41.
2007: York-Fong Cheung; Zhengyan Kan; Philip Garrett-Engele; Irene Gall; Hannah Murdoch; George S Baillie; L Miguel Camargo; Jason Johnson; Miles D Houslay; John Castle
PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6).
The Journal of pharmacology and experimental therapeutics 2007;322(2):600-9.
2007: Benjamin D Sachs; George S Baillie; Julianne R McCall; Melissa A Passino; Christian Schachtrup; Derek A Wallace; Allan J Dunlop; Kirsty F MacKenzie; Enno Klussmann; Martin J Lynch; Shoana L Sikorski; Tal Nuriel; Igor Tsigelny; Jin Zhang; Miles D Houslay; Moses V Chao; Katerina Akassoglou
p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway.
The Journal of cell biology 2007;177(6):1119-32.
2007: David G McEwan; Valerie G Brunton; George S Baillie; Nicholas R Leslie; Miles D Houslay; Margaret C Frame
Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase.
Cancer research 2007;67(11):5248-57.
2007: George S Baillie; David R Adams; Narinder Bhari; Thomas M Houslay; Suryakiran Vadrevu; Dong Meng; Xiang Li; Allan J Dunlop; Graeme Milligan; Graeme B Bolger; Enno Klussmann; Miles D Houslay
Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays.
The Biochemical journal 2007;404(1):71-80.
2007: Miles D Houslay; George S Baillie; Donald H Maurice
cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling.
Circulation research 2007;100(7):950-66.
2007: Eduard Stefan; Burkhard Wiesner; George S Baillie; Rustam Mollajew; Volker Henn; Dorothea Lorenz; Jens Furkert; Katja Santamaria; Pavel I Nedvetsky; Christian Hundsrucker; Michael Beyermann; Eberhard Krause; Peter Pohl; Irene Gall; Andrew N MacIntyre; Sebastian Bachmann; Miles D Houslay; Walter Rosenthal; Enno Klussmann
Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells.
Journal of the American Society of Nephrology : JASN 2007;18(1):199-212.
2006: Anna Terrin; Giulietta Di Benedetto; Vanessa Pertegato; York-Fong Cheung; George S Baillie; Martin J Lynch; Nicola Elvassore; Anke Prinz; Friedrich W Herberg; Miles D Houslay; Manuela Zaccolo
PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.
The Journal of cell biology 2006;175(3):441-51.
2006: Graeme B Bolger; George S Baillie; Xiang Li; Martin J Lynch; Pawel Herzyk; Ahmed Mohamed; Lisa High Mitchell; Angela McCahill; Christian Hundsrucker; Enno Klussmann; David R Adams; Miles D Houslay
Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5.
The Biochemical journal 2006;398(1):23-36.
2006: Elaine Huston; Thomas M Houslay; George S Baillie; Miles D Houslay
cAMP phosphodiesterase-4A1 (PDE4A1) has provided the paradigm for the intracellular targeting of phosphodiesterases, a process that underpins compartmentalized cAMP signalling.
Biochemical Society transactions 2006;34(Pt 4):504-9.
2006: Miles D Houslay; George S Baillie
Phosphodiesterase-4 gates the ability of protein kinase A to phosphorylate G-protein receptor kinase-2 and influence its translocation.
Biochemical Society transactions 2006;34(Pt 4):474-5.
2006: Line M Grønning; George S Baillie; Anna Cederberg; Martin J Lynch; Miles D Houslay; Sven Enerbäck; Kjetil Taskén
Reduced PDE4 expression and activity contributes to enhanced catecholamine-induced cAMP accumulation in adipocytes from FOXC2 transgenic mice.
FEBS letters 2006;580(17):4126-30.
2006: Theresa McSorley; Eduard Stefan; Volker Henn; Burkhard Wiesner; George S Baillie; Miles D Houslay; Walter Rosenthal; Enno Klussmann
Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells.
European journal of cell biology 2006;85(7):673-8.
2006: Xiang Li; Elaine Huston; Martin J Lynch; Miles D Houslay; George S Baillie
Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes.
The Biochemical journal 2006;394(Pt 2):427-35.
2005: Miles D Houslay; George S Baillie
Beta-arrestin-recruited phosphodiesterase-4 desensitizes the AKAP79/PKA-mediated switching of beta2-adrenoceptor signalling to activation of ERK.
Biochemical Society transactions 2005;33(Pt 6):1333-6.
2005: Volker Henn; Eduard Stefan; George S Baillie; Miles D Houslay; Walter Rosenthal; Enno Klussmann
Compartmentalized cAMP signalling regulates vasopressin-mediated water reabsorption by controlling aquaporin-2.
Biochemical Society transactions 2005;33(Pt 6):1316-8.
2005: J Kirsty Millar; Ben S Pickard; Shaun Mackie; Rachel James; Sheila Christie; Sebastienne R Buchanan; M Pat Malloy; Jennifer E Chubb; Elaine Huston; George S Baillie; Pippa A Thomson; Elaine V Hill; Nicholas J Brandon; Jean-Christophe Rain; L Miguel Camargo; Paul J Whiting; Miles D Houslay; D H R Blackwood; Walter J Muir; David J Porteous
DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.
Science (New York, N.Y.) 2005;310(5751):1187-91.
2005: Martin J Lynch; George S Baillie; Ahmed Mohamed; Xiang Li; Charlotte Maisonneuve; Enno Klussmann; Gino van Heeke; Miles D Houslay
RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.
The Journal of biological chemistry 2005;280(39):33178-89.
2005: George S Baillie; John D Scott; Miles D Houslay
Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract.
FEBS letters 2005;579(15):3264-70.
2005: George S Baillie; Miles D Houslay
Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes.
Current opinion in cell biology 2005;17(2):129-34.
2005: Elaine V Hill; Miles D Houslay; George S Baillie
Investigation of extracellular signal-regulated kinase 2 mitogen-activated protein kinase phosphorylation and regulation of activity of PDE4 cyclic adenosine monophosphate-specific phosphodiesterases.
Methods in molecular biology (Clifton, N.J.) 2005;307():225-37.
2004: Hilde Abrahamsen; George S Baillie; Jacob Ngai; Torkel Vang; Konstantina Nika; Anja Ruppelt; Tomas Mustelin; Manuela Zaccolo; Miles D Houslay; Kjetil Taskén
TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):4847-58.
2004: Rachael Barber; George S Baillie; Reinhard Bergmann; Malcolm C Shepherd; Ruth Sepper; Miles D Houslay; Gino Van Heeke
Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers.
American journal of physiology. Lung cellular and molecular physiology 2004;287(2):L332-43.
2004: Lee Ann Johnston; Suat Erdogan; York-Fong Cheung; Michael Sullivan; Rachael Barber; Martin J Lynch; George S Baillie; Gino van Heeke; David R Adams; Elaine Huston; Miles D Houslay
Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene.
The Biochemical journal 2004;380(Pt 2):371-84.
2004: Malcolm C Shepherd; George S Baillie; David I Stirling; Miles D Houslay
Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells.
British journal of pharmacology 2004;142(2):339-51.
2003: Graeme B Bolger; Angela McCahill; Elaine Huston; York-Fong Cheung; Theresa McSorley; George S Baillie; Miles D Houslay
The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins.
The Journal of biological chemistry 2003;278(49):49230-8.
2003: Miles D Houslay; George S Baillie
The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways.
Biochemical Society transactions 2003;31(Pt 6):1186-90.
2003: Robert Terry; York-Fong Cheung; Morten Praestegaard; George S Baillie; Elaine Huston; Irene Gall; David R Adams; Miles D Houslay
Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process.
Cellular signalling 2003;15(10):955-71.
2003: Graeme B Bolger; Alexander H Peden; Michael R Steele; Carolynn MacKenzie; David G McEwan; Derek A Wallace; Elaine Huston; George S Baillie; Miles D Houslay
Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2.
The Journal of biological chemistry 2003;278(35):33351-63.
2003: Malcolm Shepherd; Theresa McSorley; Aileen E Olsen; Lee Ann Johnston; Neil C Thomson; George S Baillie; Miles D Houslay; Graeme B Bolger
Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform.
The Biochemical journal 2003;370(Pt 2):429-38.
2003: George S Baillie; Arvind Sood; Ian McPhee; Irene Gall; Stephen J Perry; Robert J Lefkowitz; Miles D Houslay
beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):940-5.
2002: Stephen J Perry; George S Baillie; Trudy A Kohout; Ian McPhee; Maria M Magiera; Kok Long Ang; William E Miller; Alison J McLean; Marco Conti; Miles D Houslay; Robert J Lefkowitz
Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins.
Science (New York, N.Y.) 2002;298(5594):834-6.
2002: George S Baillie; Elaine Huston; Grant Scotland; Matthew N Hodgkin; Irene Gall; Alexander H Peden; Carolynn MacKenzie; Emma S Houslay; Richard Currie; Trevor R Pettitt; Adrian R Walmsley; Michael J O Wakelam; Jim Warwicker; Miles D Houslay
TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid.
The Journal of biological chemistry 2002;277(31):28298-309.
2002: Simon MacKenzie; George S Baillie; Ian McPhee; Carolynn MacKenzie; Rachael Seamons; Theresa McSorley; Jennifer Millen; Matthew B Beard; Gino van Heeke; Miles D Houslay
Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1).
British journal of pharmacology 2002;136(3):421-33.
2002: Berit Adam; George S Baillie; L Julia Douglas
Mixed species biofilms of Candida albicans and Staphylococcus epidermidis.
Journal of medical microbiology 2002;51(4):344-9.
2001: George S Baillie; Simon MacKenzie; Miles D Houslay
Phorbol 12-myristate 13-acetate triggers the protein kinase A-mediated phosphorylation and activation of the PDE4D5 cAMP phosphodiesterase in human aortic smooth muscle cells through a route involving extracellular signal regulated kinase (ERK).
Molecular pharmacology 2001;60(5):1100-11.
2000: George S Baillie; Simon MacKenzie; Ian McPhee; Miles D Houslay
Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases.
British journal of pharmacology 2000;131(4):811-9.
2000: Simon MacKenzie; George S Baillie; Ian McPhee; Graeme B Bolger; Miles D Houslay
ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions.
The Journal of biological chemistry 2000;275(22):16609-17.
1999: George S Baillie; L Julia Douglas
Role of dimorphism in the development of Candida albicans biofilms.
Journal of medical microbiology 1999;48(7):671-9.
1999: R Hoffmann; George S Baillie; Simon MacKenzie; Stephen J Yarwood; Miles D Houslay
The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579.
The EMBO journal 1999;18(4):893-903.
1999: George S Baillie; L Julia Douglas
Candida biofilms and their susceptibility to antifungal agents.
Methods in enzymology 1999;310():644-56.
1998: S P Hawser; George S Baillie; L Julia Douglas
Production of extracellular matrix by Candida albicans biofilms.
Journal of medical microbiology 1998;47(3):253-6.