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Thomas Baillie

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Zhican Wang; Xi Emily Zheng; Thomas A Baillie; David Blough; Connie L Davis; Leslie J Dickmann; Takanori Hashizume; Mary F Hebert; Yvonne S Lin; Sidney D Nelson; Michele Scian; T Senn; Kenneth E Thummel
An inducible cytochrome P450 3A4-dependent vitamin D catabolic pathway.
Thomas A Baillie; Allan E Rettie
Role of biotransformation in drug-induced toxicity: influence of intra- and inter-species differences in drug metabolism.
Sanjeev Kumar; Kaushik Mitra; Kelem Kassahun; Thomas A Baillie
Approaches for minimizing metabolic activation of new drug candidates in drug discovery.

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2012: Zhican Wang; Xi Emily Zheng; Thomas A Baillie; David Blough; Connie L Davis; Leslie J Dickmann; Takanori Hashizume; Mary F Hebert; Yvonne S Lin; Sidney D Nelson; Michele Scian; T Senn; Kenneth E Thummel
An inducible cytochrome P450 3A4-dependent vitamin D catabolic pathway.
Molecular pharmacology 2012;81(4):498-509.
2011: Thomas A Baillie; Allan E Rettie
Role of biotransformation in drug-induced toxicity: influence of intra- and inter-species differences in drug metabolism.
Drug metabolism and pharmacokinetics 2011;26(1):15-29.
2010: Sanjeev Kumar; Kaushik Mitra; Kelem Kassahun; Thomas A Baillie
Approaches for minimizing metabolic activation of new drug candidates in drug discovery.
Handbook of experimental pharmacology 2010;(196):511-44.
2008: Philip R Tiller; Sean Yu; Kevin P Bateman; Jose Castro-Perez; Ian S McIntosh; Yushin Kuo; Thomas A Baillie
Fractional mass filtering as a means to assess circulating metabolites in early human clinical studies.
Rapid communications in mass spectrometry : RCM 2008;22(22):3510-6.
2008: Wei Tang; Ralph A Stearns; Regina W Wang; Randall R Miller; Qing Chen; Jason S Ngui; Raman K Bakshi; Ravi P Nargund; Dennis C Dean; Thomas A Baillie
Assessing and minimizing time-dependent inhibition of cytochrome P450 3A in drug discovery: a case study with melanocortin-4 receptor agonists.
Xenobiotica; the fate of foreign compounds in biological systems 2008;38(11):1437-51.
2008: Philip R Tiller; Sean Yu; Jose Castro-Perez; Kerry L Fillgrove; Thomas A Baillie
High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-of-flight system as a 'first-line' approach for metabolite identification studies.
Rapid communications in mass spectrometry : RCM 2008;22(7):1053-61.
2008: Wei Tang; Ralph A Stearns; Qing Chen; K Bleasby; Yohannes Teffera; Adria Colletti; M Hafey; Raymond Evers; Dennis C Dean; Plato A Magriotis; Thomas J Lanza; Linus S Lin; William K Hagmann; Thomas A Baillie
Importance of mechanistic drug metabolism studies in support of drug discovery: A case study with an N -sulfonylated dipeptide VLA-4 antagonist in rats.
Xenobiotica; the fate of foreign compounds in biological systems 2008;38(2):223-37.
2008: Ying Li; J Greg Slatter; Zhoupeng Zhang; Yan Li; George A Doss; Matthew P Braun; Ralph A Stearns; Dennis C Dean; Thomas A Baillie; Wei Tang
In vitro metabolic activation of lumiracoxib in rat and human liver preparations.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(2):469-73.
2008: Sanjeev Kumar; Kelem Kassahun; Richard A Tschirret-Guth; Kaushik Mitra; Thomas A Baillie
Minimizing metabolic activation during pharmaceutical lead optimization: progress, knowledge gaps and future directions.
Current opinion in drug discovery & development 2008;11(1):43-52.
2008: Thomas A Baillie
Metabolism and toxicity of drugs. Two decades of progress in industrial drug metabolism.
Chemical research in toxicology 2008;21(1):129-37.
2007: Punam Sandhu; Paul A Andrews; Maribeth P Baker; Kenneth A Koeplinger; Eric D Soli; Thomas Miller; Thomas A Baillie
Disposition of vorinostat, a novel histone deacetylase inhibitor and anticancer agent, in preclinical species.
Drug metabolism letters 2007;1(2):153-61.
2006: Thomayant Prueksaritanont; Jiunn H Lin; Thomas A Baillie
Complicating factors in safety testing of drug metabolites: kinetic differences between generated and preformed metabolites.
Toxicology and applied pharmacology 2006;217(2):143-52.
2006: Thomas A Baillie
Future of toxicology-metabolic activation and drug design: challenges and opportunities in chemical toxicology.
Chemical research in toxicology 2006;19(7):889-93.
2006: George A Doss; Thomas A Baillie
Addressing metabolic activation as an integral component of drug design.
Drug metabolism reviews 2006;38(4):641-9.
2006: Qing Chen; George A Doss; Elaine C Tung; Wensheng Liu; Yui S Tang; Matthew P Braun; Varsha Didolkar; John R Strauss; Regina W Wang; Ralph A Stearns; David C Evans; Thomas A Baillie; Wei Tang
Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(1):145-51.
2005: Kelem Kassahun; Konstantine Skordos; Ian McIntosh; Donald E Slaughter; George A Doss; Thomas A Baillie; Garold S Yost
Zafirlukast metabolism by cytochrome P450 3A4 produces an electrophilic alpha,beta-unsaturated iminium species that results in the selective mechanism-based inactivation of the enzyme.
Chemical research in toxicology 2005;18(9):1427-37.
2005: Christopher R Gibson; Charles Lin; Rominder Singh; Cheri M Brown; Karen Richards; Janice Brunner; Kimberly Michel; Jennifer K Adelsberger; Edward J Carlini; Catherine Boothe-Genthe; Conrad E Raab; Minh Luu; Aimee Michael; Mona Parikh; Patrice A Ciecko; Raju Subramanian; Paul Krolikowski; A David Rodrigues; Thomas A Baillie; Thomas H Rushmore
Induction of CYP1A in the beagle dog by an inhibitor of kinase insert domain-containing receptor: differential effects in vitro and in vivo on mRNA and functional activity.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(7):1044-51.
2005: Cuyue Tang; Raju Subramanian; Yuhsin Kuo; Sergey Krymgold; Ping Lu; Scott D Kuduk; Christina Ng; Dong-Mei Feng; Chad Elmore; Eric Soli; Jonathan Ho; Mark G Bock; Thomas A Baillie; Thomayant Prueksaritanont
Bioactivation of 2,3-diaminopyridine-containing bradykinin B1 receptor antagonists: irreversible binding to liver microsomal proteins and formation of glutathione conjugates.
Chemical research in toxicology 2005;18(6):934-45.
2005: M Reza Anari; Thomas A Baillie
Bridging cheminformatic metabolite prediction and tandem mass spectrometry.
Drug discovery today 2005;10(10):711-7.
2005: Vijay Bhasker G Reddy; Bindhu V Karanam; Wendy L Gruber; Michael A Wallace; Stella H Vincent; Ronald B Franklin; Thomas A Baillie
Mechanistic studies on the metabolic scission of thiazolidinedione derivatives to acyclic thiols.
Chemical research in toxicology 2005;18(5):880-8.
2005: Zhoupeng Zhang; Qing Chen; Ying Li; George A Doss; Brian J Dean; Jason S Ngui; Maria V Silva Elipe; Seongkon Kim; Jane Y Wu; Frank DiNinno; Milton L Hammond; Ralph A Stearns; David C Evans; Thomas A Baillie; Wei Tang
In vitro bioactivation of dihydrobenzoxathiin selective estrogen receptor modulators by cytochrome P450 3A4 in human liver microsomes: formation of reactive iminium and quinone type metabolites.
Chemical research in toxicology 2005;18(4):675-85.
2005: Christine M Dieckhaus; Carmen L Fernández-Metzler; Richard King; Paul Krolikowski; Thomas A Baillie
Negative ion tandem mass spectrometry for the detection of glutathione conjugates.
Chemical research in toxicology 2005;18(4):630-8.
2005: George A Doss; Randall R Miller; Zhoupeng Zhang; Yohannes Teffera; Ravi P Nargund; Brenda L Palucki; Min K Park; Yui S Tang; David C Evans; Thomas A Baillie; Ralph A Stearns
Metabolic activation of a 1,3-disubstituted piperazine derivative: evidence for a novel ring contraction to an imidazoline.
Chemical research in toxicology 2005;18(2):271-6.
2004: Punam Sandhu; John S Vogel; Mark J Rose; Esther A Ubick; Janice E Brunner; Michael A Wallace; Jennifer K Adelsberger; Maribeth P Baker; Paul Henderson; Paul G Pearson; Thomas A Baillie
Evaluation of microdosing strategies for studies in preclinical drug development: demonstration of linear pharmacokinetics in dogs of a nucleoside analog over a 50-fold dose range.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(11):1254-9.
2004: Qing Chen; Eugene Tan; John R Strauss; Zhoupeng Zhang; Judy Fenyk-Melody; Catherine Booth-Genthe; Thomas H Rushmore; Ralph A Stearns; David C Evans; Thomas A Baillie; Wei Tang
Effect of quinidine on the 10-hydroxylation of R-warfarin: species differences and clearance projection.
The Journal of pharmacology and experimental therapeutics 2004;311(1):307-14.
2004: Xiaoxin Cai; Regina W Wang; Richard W Edom; David C Evans; Magang Shou; A David Rodrigues; Wensheng Liu; Dennis C Dean; Thomas A Baillie
Validation of (-)-N-3-benzyl-phenobarbital as a selective inhibitor of CYP2C19 in human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(6):584-6.
2004: Wenji Yin; Kaushik Mitra; Ralph A Stearns; Thomas A Baillie; Sanjeev Kumar
Conversion of the 2,2,6,6-tetramethylpiperidine moiety to a 2,2-dimethylpyrrolidine by cytochrome P450: evidence for a mechanism involving nitroxide radicals and heme iron.
Biochemistry 2004;43(18):5455-66.
2004: Zhoupeng Zhang; Ying Li; Magang Shou; Y Zhang; Jason S Ngui; Ralph A Stearns; David C Evans; Thomas A Baillie; Wei Tang
Influence of different recombinant systems on the cooperativity exhibited by cytochrome P4503A4.
Xenobiotica; the fate of foreign compounds in biological systems 2004;34(5):473-86.
2004: M Reza Anari; Rosa I Sanchez; Ray Bakhtiar; Ronald B Franklin; Thomas A Baillie
Integration of knowledge-based metabolic predictions with liquid chromatography data-dependent tandem mass spectrometry for drug metabolism studies: application to studies on the biotransformation of indinavir.
Analytical chemistry 2004;76(3):823-32.
2004: Su-Er W Huskey; Brian J Dean; George A Doss; Zhen Wang; Cornelis E C A Hop; Reza Anari; Paul E Finke; Albert J Robichaud; Minghua Zhang; Bonnie Wang; John R Strauss; Paul K Cunningham; William P Feeney; Ronald B Franklin; Thomas A Baillie; Shuet-Hing Lee Chiu
The metabolic disposition of aprepitant, a substance P receptor antagonist, in rats and dogs.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(2):246-58.
2003: Donald E Slaughter; Norihiro Takenaga; Ping Lu; Carol Assang; Deborah J Walsh; Byron H Arison; Donghui Cui; Rita A Halpin; Leslie A Geer; Kamlesh P Vyas; Thomas A Baillie
Metabolism of rofecoxib in vitro using human liver subcellular fractions.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(11):1398-408.
2003: Sanjeev Kumar; Gloria Y Kwei; Grace K Poon; Susan A Iliff; Yanfeng Wang; Qing Chen; Ronald B Franklin; Varsha Didolkar; Regina W Wang; Masayo Yamazaki; Shuet-Hing Lee Chiu; Jiunn H Lin; Paul G Pearson; Thomas A Baillie
Pharmacokinetics and interactions of a novel antagonist of chemokine receptor 5 (CCR5) with ritonavir in rats and monkeys: role of CYP3A and P-glycoprotein.
The Journal of pharmacology and experimental therapeutics 2003;304(3):1161-71.
2003: Rominder Singh; Maria V Silva Elipe; Paul G Pearson; Byron H Arison; Bradley K Wong; Rebecca White; Xiao Yu; Christopher S Burgey; Jiunn H Lin; Thomas A Baillie
Metabolic activation of a pyrazinone-containing thrombin inhibitor. Evidence for novel biotransformation involving pyrazinone ring oxidation, rearrangement, and covalent binding to proteins.
Chemical research in toxicology 2003;16(2):198-207.
2003: M Reza Anari; Ray Bakhtiar; Ronald B Franklin; Paul G Pearson; Thomas A Baillie
Study of the fragmentation mechanism of protonated 6-hydroxychlorzoxazone: application in simultaneous analysis of CYP2E1 activity with major human cytochrome P450s.
Analytical chemistry 2003;75(3):469-78.
2003: Zhen Wang; Cornelis E C A Hop; Mi-Sook Kim; Su-Er W Huskey; Thomas A Baillie; Ziqiang Guan
The unanticipated loss of SO2 from sulfonamides in collision-induced dissociation.
Rapid communications in mass spectrometry : RCM 2003;17(1):81-6.
2002: Sanjeev Kumar; Koppara Samuel; Raju Subramanian; Matthew P Braun; Ralph A Stearns; Shuet-Hing Lee Chiu; David C Evans; Thomas A Baillie
Extrapolation of diclofenac clearance from in vitro microsomal metabolism data: role of acyl glucuronidation and sequential oxidative metabolism of the acyl glucuronide.
The Journal of pharmacology and experimental therapeutics 2002;303(3):969-78.
2002: Thomas A Baillie; Mitchell N Cayen; Hassan Fouda; Ronald J Gerson; James D Green; Scott J Grossman; Lewis J Klunk; Bernard LeBlanc; Darcy G Perkins; Lisa A Shipley
Drug metabolites in safety testing.
Toxicology and applied pharmacology 2002;182(3):188-96.
2002: Qing Chen; Jason S Ngui; George A Doss; Regina W Wang; Xiaoxin Cai; Frank DiNinno; Timothy A Blizzard; Milton L Hammond; Ralph A Stearns; David C Evans; Thomas A Baillie; Wei Tang
Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation.
Chemical research in toxicology 2002;15(7):907-14.
2002: Wei Tang; Ralph A Stearns; Randall R Miller; Jason S Ngui; Robert J Mathvink; Ann E Weber; Gloria Y Kwei; John R Strauss; Carol Ann Keohane; George A Doss; Shuet-Hing Lee Chiu; Thomas A Baillie
Metabolism of a thiazole benzenesulfonamide derivative, a potent and elective agonist of the human beta3-adrenergic receptor, in rats: identification of a novel isethionic acid conjugate.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(7):778-87.
2002: Thomayant Prueksaritanont; Jamie J Zhao; Bennett Ma; Brad A Roadcap; Cuyue Tang; Yue Qiu; Lida Liu; Jiunn H Lin; Paul G Pearson; Thomas A Baillie
Mechanistic studies on metabolic interactions between gemfibrozil and statins.
The Journal of pharmacology and experimental therapeutics 2002;301(3):1042-51.
2002: Rita A Halpin; Arturo G Porras; Leslie A Geer; Margaret R Davis; Donghui Cui; George A Doss; Eric J Woolf; Donald G Musson; Catherine Matthews; Ralph S Mazenko; Jules I Schwartz; Kenneth C Lasseter; Kamlesh P Vyas; Thomas A Baillie
The disposition and metabolism of rofecoxib, a potent and selective cyclooxygenase-2 inhibitor, in human subjects.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(6):684-93.
2002: Thomayant Prueksaritanont; Raju Subramanian; Xiaojun Fang; Bennett Ma; Yue Qiu; Jiunn H Lin; Paul G Pearson; Thomas A Baillie
Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(5):505-12.
2002: Zhoupeng Zhang; Ying Li; Ralph A Stearns; Paul R. Ortiz de Montellano; Thomas A Baillie; Wei Tang
Cytochrome P450 3A4-mediated oxidative conversion of a cyano to an amide group in the metabolism of pinacidil.
Biochemistry 2002;41(8):2712-8.
2002: Claudia M Jochheim; Margaret R Davis; Kathleen M Baillie; William J Ehlhardt; Thomas A Baillie
Glutathione-dependent metabolism of the antitumor agent sulofenur. Evidence for the formation of p-chlorophenyl isocyanate as a reactive intermediate.
Chemical research in toxicology 2002;15(2):240-8.
2001: Thomas A Baillie; Rita A Halpin; Bogdan K Matuszewski; Leslie A Geer; Cynthia M Chavez-Eng; Dennis Dean; Matt Braun; George A Doss; A Jones; T Marks; David G Melillo; Kamlesh P Vyas
Mechanistic studies on the reversible metabolism of rofecoxib to 5-hydroxyrofecoxib in the rat: evidence for transient ring opening of a substituted 2-furanone derivative using stable isotope-labeling techniques.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(12):1614-28.
2001: Grace K Poon; Qing Chen; Yohannes Teffera; Jason S Ngui; Patrick R Griffin; Matthew P Braun; George A Doss; C Freeden; Ralph A Stearns; David C Evans; Thomas A Baillie; Wei Tang
Bioactivation of diclofenac via benzoquinone imine intermediates-identification of urinary mercapturic acid derivatives in rats and humans.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(12):1608-13.
2001: Ping Lu; Yuh Lin; A David Rodrigues; Thomas H Rushmore; Thomas A Baillie; Magang Shou
Testosterone, 7-benzyloxyquinoline, and 7-benzyloxy-4-trifluoromethyl-coumarin bind to different domains within the active site of cytochrome P450 3A4.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(11):1473-9.
2001: Jason S Ngui; Qing Chen; Magang Shou; Regina W Wang; Ralph A Stearns; Thomas A Baillie; Wei Tang
In vitro stimulation of warfarin metabolism by quinidine: increases in the formation of 4'- and 10-hydroxywarfarin.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(6):877-86.
2001: Magang Shou; Y Lin; P Lu; Cuyue Tang; Qin Mei; Donghui Cui; Wei Tang; Jason S Ngui; C C Lin; Rominder Singh; Bradley K Wong; J A Yergey; Jiunn H Lin; Paul G Pearson; Thomas A Baillie; A David Rodrigues; Thomas H Rushmore
Enzyme kinetics of cytochrome P450-mediated reactions.
Current drug metabolism 2001;2(1):17-36.
2001: Magang Shou; R Dai; D Cui; Kenneth R Korzekwa; Thomas A Baillie; Thomas H Rushmore
A kinetic model for the metabolic interaction of two substrates at the active site of cytochrome P450 3A4.
The Journal of biological chemistry 2001;276(3):2256-62.
2001: Thomas A Baillie; Kelem Kassahun
Biological reactive intermediates in drug discovery and development: a perspective from the pharmaceutical industry.
Advances in experimental medicine and biology 2001;500():45-51.
2001: Kelem Kassahun; Paul G Pearson; Wei Tang; Ian McIntosh; K Leung; C Elmore; Dennis Dean; R Wang; George A Doss; Thomas A Baillie
Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.
Chemical research in toxicology 2001;14(1):62-70.
2000: Suresh K Balani; Xin Xu; Byron H Arison; M V Silva; A Gries; Florencia deLuna; Donghui Cui; Prasad H Kari; T Ly; Cornelis E C A Hop; Rominder Singh; Michael A Wallace; Dennis C Dean; Jiunn H Lin; Paul G Pearson; Thomas A Baillie
Metabolites of caspofungin acetate, a potent antifungal agent, in human plasma and urine.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(11):1274-8.
2000: Jason S Ngui; Wei Tang; Ralph A Stearns; Magang Shou; Randall R Miller; Y Zhang; Jiunn H Lin; Thomas A Baillie
Cytochrome P450 3A4-mediated interaction of diclofenac and quinidine.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(9):1043-50.
2000: KE Zhang; Prasad H Kari; Margaret R Davis; George A Doss; Thomas A Baillie; Kamlesh P Vyas
Metabolism of A dopamine D(4)-selective antagonist in rat, monkey, and humans: formation of A novel mercapturic acid adduct.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(6):633-42.
1999: Xiangming Guan; Margaret R Davis; C Tang; C M Jochheim; L Jin; Thomas A Baillie
Identification of S-(n-butylcarbamoyl)glutathione, a reactive carbamoylating metabolite of tolbutamide in the rat, and evaluation of its inhibitory effects on glutathione reductase in vitro.
Chemical research in toxicology 1999;12(12):1138-43.
1999: Wei Tang; Ralph A Stearns; Gloria Y Kwei; Susan A Iliff; Randall R Miller; Marjorie A Egan; Nathan X Yu; Dennis C Dean; Sanjeev Kumar; Magang Shou; Jiunn H Lin; Thomas A Baillie
Interaction of diclofenac and quinidine in monkeys: stimulation of diclofenac metabolism.
The Journal of pharmacology and experimental therapeutics 1999;291(3):1068-74.
1999: Qin Mei; Cuyue Tang; Carol Assang; Y Lin; Donald E Slaughter; A David Rodrigues; Thomas A Baillie; Thomas H Rushmore; Magang Shou
Role of a potent inhibitory monoclonal antibody to cytochrome P-450 3A4 in assessment of human drug metabolism.
The Journal of pharmacology and experimental therapeutics 1999;291(2):749-59.
1999: Magang Shou; Qin Mei; M W Ettore; R Dai; Thomas A Baillie; Thomas H Rushmore
Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives.
The Biochemical journal 1999;340 ( Pt 3)():845-53.
1999: Thomayant Prueksaritanont; Bennett Ma; Cuyue Tang; Y Meng; Carol Assang; Ping Lu; P J Reider; Jiunn H Lin; Thomas A Baillie
Metabolic interactions between mibefradil and HMG-CoA reductase inhibitors: an in vitro investigation with human liver preparations.
British journal of clinical pharmacology 1999;47(3):291-8.
1999: Wei Tang; Ralph A Stearns; S M Bandiera; Y Zhang; Conrad E Raab; Matthew P Braun; Dennis C Dean; Jianmei Pang; Kwan H Leung; George A Doss; John R Strauss; Gloria Y Kwei; Thomas H Rushmore; Shuet-Hing Lee Chiu; Thomas A Baillie
Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(3):365-72.
1999: Wei Tang; Ralph A Stearns; Regina W Wang; Shuet-Hing Lee Chiu; Thomas A Baillie
Roles of human hepatic cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac.
Chemical research in toxicology 1999;12(2):192-9.
1999: Carmen L Fernández-Metzler; K G Owens; Thomas A Baillie; Richard C King
Rapid liquid chromatography with tandem mass spectrometry-based screening procedures for studies on the biotransformation of drug candidates.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(1):32-40.
1997: K Kassahun; M Davis; P Hu; B Martin; Thomas A Baillie
Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat: identification of phase I metabolites and glutathione conjugates.
Chemical research in toxicology 1997;10(11):1228-33.
1997: Suresh K Balani; Xin Xu; Vijaya S Pratha; M A Koss; RD Amin; C Dufresne; Randall R Miller; Byron H Arison; George A Doss; M Chiba; A Freeman; Sherry D Holland; Jules I Schwartz; Kenneth C Lasseter; Barry J Gertz; Jon I Isenberg; John D Rogers; Jiunn H Lin; Thomas A Baillie
Metabolic profiles of montelukast sodium (Singulair), a potent cysteinyl leukotriene1 receptor antagonist, in human plasma and bile.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(11):1282-7.
1997: Thomayant Prueksaritanont; LM Gorham; Michael J Breslin; John H Hutchinson; George D Hartman; Kamlesh P Vyas; Thomas A Baillie
In vitro and in vivo evaluations of the metabolism, pharmacokinetics, and bioavailability of ester prodrugs of L-767,679, a potent fibrinogen receptor antagonist: an approach for the selection of a prodrug candidate.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(8):978-84.
1997: P Hu; L Jin; Thomas A Baillie
Studies on the metabolic activation of disulfiram in rat. Evidence for electrophilic S-oxygenated metabolites as inhibitors of aldehyde dehydrogenase and precursors of urinary N-acetylcysteine conjugates.
The Journal of pharmacology and experimental therapeutics 1997;281(2):611-7.
1997: L Jin; Thomas A Baillie
Metabolism of the chemoprotective agent diallyl sulfide to glutathione conjugates in rats.
Chemical research in toxicology 1997;10(3):318-27.
1997: S W Martin; FE Bishop; B M Kerr; M Moor; M Moore; Pamela Sheffels; M Rashed; J Greg Slatter; L Berthon-Cédille; F Lepage; J J Descombe; M Picard; Thomas A Baillie; René H Levy
Pharmacokinetics and metabolism of the novel anticonvulsant agent N-(2,6-dimethylphenyl)-5-methyl-3-isoxazolecarboxamide (D2624) in rats and humans.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(1):40-6.
1996: Y Sahali-Sahly; Suresh K Balani; Jiunn H Lin; Thomas A Baillie
In vitro studies on the metabolic activation of the furanopyridine L-754,394, a highly potent and selective mechanism-based inhibitor of cytochrome P450 3A4.
Chemical research in toxicology 1996;9(6):1007-12.
1996: L Jin; Margaret R Davis; Evan D Kharasch; George A Doss; Thomas A Baillie
Identification in rat bile of glutathione conjugates of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether, a nephrotoxic degradate of the anesthetic agent sevoflurane.
Chemical research in toxicology 1996;9(2):555-61.
1995: Allan E Rettie; P R Sheffels; Kenneth R Korzekwa; F J Gonzalez; RM Philpot; Thomas A Baillie
CYP4 isozyme specificity and the relationship between omega-hydroxylation and terminal desaturation of valproic acid.
Biochemistry 1995;34(24):7889-95.
1995: L Jin; Thomas A Baillie; Margaret R Davis; Evan D Kharasch
Nephrotoxicity of sevoflurane compound A [fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether] in rats: evidence for glutathione and cysteine conjugate formation and the role of renal cysteine conjugate beta-lyase.
Biochemical and biophysical research communications 1995;210(2):498-506.
1994: K Kassahun; C M Jochheim; Thomas A Baillie
Effect of carbamate thioester derivatives of methyl- and 2-chloroethyl isocyanate on glutathione levels and glutathione reductase activity in isolated rat hepatocytes.
Biochemical pharmacology 1994;48(3):587-94.
1994: L Jin; Margaret R Davis; P Hu; Thomas A Baillie
Identification of novel glutathione conjugates of disulfiram and diethyldithiocarbamate in rat bile by liquid chromatography-tandem mass spectrometry. Evidence for metabolic activation of disulfiram in vivo.
Chemical research in toxicology 1994;7(4):526-33.
1994: C Tang; K Zhang; F Lepage; René H Levy; Thomas A Baillie
Metabolic chiral inversion of stiripentol in the rat. II. Influence of route of administration.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(4):554-60.
1994: K Zhang; C Tang; M Rashed; D Cui; F Tombret; H Botte; F Lepage; René H Levy; Thomas A Baillie
Metabolic chiral inversion of stiripentol in the rat. I. Mechanistic studies.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(4):544-53.
1994: M A Shirley; X Guan; D G Kaiser; G W Halstead; Thomas A Baillie
Taurine conjugation of ibuprofen in humans and in rat liver in vitro. Relationship to metabolic chiral inversion.
The Journal of pharmacology and experimental therapeutics 1994;269(3):1166-75.
1994: R H Arends; K Zhang; René H Levy; Thomas A Baillie; Danny D Shen
Stereoselective pharmacokinetics of stiripentol: an explanation for the development of tolerance to anticonvulsant effect.
Epilepsy research 1994;18(2):91-6.
1994: C M Jochheim; Thomas A Baillie
Selective and irreversible inhibition of glutathione reductase in vitro by carbamate thioester conjugates of methyl isocyanate.
Biochemical pharmacology 1994;47(7):1197-206.
1994: K Kassahun; P Hu; M P Grillo; Margaret R Davis; L Jin; Thomas A Baillie
Metabolic activation of unsaturated derivatives of valproic acid. Identification of novel glutathione adducts formed through coenzyme A-dependent and -independent processes.
Chemico-biological interactions 1994;90(3):253-75.
1994: Thomas A Baillie; K Kassahun
Reversibility in glutathione-conjugate formation.
Advances in pharmacology (San Diego, Calif.) 1994;27():163-81.
1993: M A Shirley; P Hu; Thomas A Baillie
Stereochemical studies on the beta-oxidation of valproic acid in isolated rat hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(4):580-6.
1993: Thomas A Baillie; M R Davis
Mass spectrometry in the analysis of glutathione conjugates.
Biological mass spectrometry 1993;22(6):319-25.
1993: Margaret R Davis; K Kassahun; C M Jochheim; K M Brandt; Thomas A Baillie
Glutathione and N-acetylcysteine conjugates of 2-chloroethyl isocyanate. Identification as metabolites of N,N'-bis(2-chloroethyl)-N-nitrosourea in the rat and inhibitory properties toward glutathione reductase in vitro.
Chemical research in toxicology 1993;6(3):376-83.
1993: J Greg Slatter; Margaret R Davis; D H Han; P G Pearson; Thomas A Baillie
Studies on the metabolic fate of caracemide, an experimental antitumor agent, in the rat. Evidence for the release of methyl isocyanate in vivo.
Chemical research in toxicology 1993;6(3):335-40.
1993: K Kassahun; Thomas A Baillie
Cytochrome P-450-mediated dehydrogenation of 2-n-propyl-2(E)-pentenoic acid, a pharmacologically-active metabolite of valproic acid, in rat liver microsomal preparations.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(2):242-8.
1992: Thomas A Baillie
Metabolism of valproate to hepatotoxic intermediates.
Pharmaceutisch weekblad. Scientific edition 1992;14(3A):122-5.
1991: P G Pearson; J Greg Slatter; M S Rashed; D H Han; Thomas A Baillie
Carbamoylation of peptides and proteins in vitro by S-(N-methylcarbamoyl)glutathione and S-(N-methylcarbamoyl)cysteine, two electrophilic S-linked conjugates of methyl isocyanate.
Chemical research in toxicology 1991;4(4):436-44.
1991: S M Bjorge; Thomas A Baillie
Studies on the beta-oxidation of valproic acid in rat liver mitochondrial preparations.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(4):823-9.
1991: D J Porubek; S M Sanins; J R Stephens; M P Grillo; D G Kaiser; G W Halstead; Wade J Adams; Thomas A Baillie
Metabolic chiral inversion of flurbiprofen-CoA in vitro.
Biochemical pharmacology 1991;42(1):R1-4.
1991: A V Boddy; K Zhang; F Lepage; F Tombret; J Greg Slatter; Thomas A Baillie; René H Levy
In vitro and in vivo investigations of dihydropyridine-based chemical delivery systems for anticonvulsants.
Pharmaceutical research 1991;8(6):690-7.
1991: J Greg Slatter; M S Rashed; P G Pearson; D H Han; Thomas A Baillie
Biotransformation of methyl isocyanate in the rat. Evidence for glutathione conjugation as a major pathway of metabolism and implications for isocyanate-mediated toxicities.
Chemical research in toxicology 1991;4(2):157-61.
1991: S M Sanins; Wade J Adams; D G Kaiser; G W Halstead; J Hosley; H Barnes; Thomas A Baillie
Mechanistic studies on the metabolic chiral inversion of R-ibuprofen in the rat.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(2):405-10.
1990: René H Levy; A W Rettenmeier; Gail D Anderson; Alan J Wilensky; P N Friel; Thomas A Baillie; A Acheampong; J Tor; M Guyot; P Loiseau
Effects of polytherapy with phenytoin, carbamazepine, and stiripentol on formation of 4-ene-valproate, a hepatotoxic metabolite of valproic acid.
Clinical pharmacology and therapeutics 1990;48(3):225-35.
1990: S M Sanins; Wade J Adams; D G Kaiser; G W Halstead; Thomas A Baillie
Studies on the metabolism and chiral inversion of ibuprofen in isolated rat hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(4):527-33.
1990: K J Hoffmann; Axworthy Don; Thomas A Baillie
Mechanistic studies on the metabolic activation of acetaminophen in vivo.
Chemical research in toxicology 1990;3(3):204-11.
1990: D H Han; P G Pearson; Thomas A Baillie; R Dayal; L H Tsang; A Gescher
Chemical synthesis and cytotoxic properties of N-alkylcarbamic acid thioesters, metabolites of hepatotoxic formamides.
Chemical research in toxicology 1990;3(2):118-24.
1990: P G Pearson; J Greg Slatter; M S Rashed; D H Han; M P Grillo; Thomas A Baillie
S-(N-methylcarbamoyl)glutathione: a reactive S-linked metabolite of methyl isocyanate.
Biochemical and biophysical research communications 1990;166(1):245-50.
1989: K M Koch; K S Prickett; A W Rettenmeier; Thomas A Baillie; René H Levy
Beta-oxidation of valproate. II. Effects of fasting, glucose, and clofibrate in rats.
Epilepsia 1989;30(6):790-6.
1989: M S Rashed; P G Pearson; D H Han; Thomas A Baillie
Application of liquid chromatography/thermospray mass spectrometry to studies on the formation of glutathione and cysteine conjugates from monomethylcarbamate metabolites of bambuterol.
Rapid communications in mass spectrometry : RCM 1989;3(10):360-3.
1989: L Y Leung; Thomas A Baillie
Studies on the biotransformation of ketamine. II--Quantitative significance of the N-demethylation pathway in rats in vivo determined by a novel stable isotope technique.
Biomedical & environmental mass spectrometry 1989;18(6):401-4.
1989: Thomas A Baillie; Wade J Adams; D G Kaiser; L S Olanoff; G W Halstead; H Harpootlian; G J Van Giessen
Mechanistic studies of the metabolic chiral inversion of (R)-ibuprofen in humans.
The Journal of pharmacology and experimental therapeutics 1989;249(2):517-23.
1989: D J Porubek; M P Grillo; Thomas A Baillie
The covalent binding to protein of valproic acid and its hepatotoxic metabolite, 2-n-propyl-4-pentenoic acid, in rats and in isolated rat hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(2):123-30.
1989: A W Rettenmeier; William N Howald; René H Levy; D J Witek; W P Gordon; D J Porubek; Thomas A Baillie
Quantitative metabolic profiling of valproic acid in humans using automated gas chromatographic/mass spectrometric techniques.
Biomedical & environmental mass spectrometry 1989;18(3):192-9.
1989: D J Porubek; H Barnes; G P Meier; L J Theodore; Thomas A Baillie
Enantiotopic differentiation during the biotransformation of valproic acid to the hepatotoxic olefin 2-n-propyl-4-pentenoic acid.
Chemical research in toxicology 1989;2(1):35-40.
1989: Thomas A Baillie; P G Pearson; M S Rashed; William N Howald
The use of mass spectrometry in the study of chemically-reactive drug metabolites. Application of MS/MS and LC/MS to the analysis of glutathione- and related S-linked conjugates of N-methylformamide.
Journal of pharmaceutical and biomedical analysis 1989;7(12):1351-60.
1988: D J Porubek; H Barnes; L J Theodore; Thomas A Baillie
Enantioselective synthesis and preliminary metabolic studies of the optical isomers of 2-n-propyl-4-pentenoic acid, a hepatotoxic metabolite of valproic acid.
Chemical research in toxicology 1988;1(6):343-8.
1988: P G Pearson; Michael Threadgill; William N Howald; Thomas A Baillie
Applications of tandem mass spectrometry to the characterization of derivatized glutathione conjugates. Studies with S-(N-methylcarbamoyl)glutathione, a metabolite of the antineoplastic agent N-methylformamide.
Biomedical & environmental mass spectrometry 1988;16(1-12):51-6.
1988: Allan E Rettie; M Boberg; A W Rettenmeier; Thomas A Baillie
Cytochrome P-450-catalyzed desaturation of valproic acid in vitro. Species differences, induction effects, and mechanistic studies.
The Journal of biological chemistry 1988;263(27):13733-8.
1988: Thomas A Baillie
Metabolic activation of valproic acid and drug-mediated hepatotoxicity. Role of the terminal olefin, 2-n-propyl-4-pentenoic acid.
Chemical research in toxicology 1988;1(4):195-9.
1988: K J Hoffmann; Thomas A Baillie
The use of alkoxycarbonyl derivatives for the mass spectral analysis of drug-thioether metabolites. Studies with the cysteine, mercapturic acid and glutathione conjugates of acetaminophen.
Biomedical & environmental mass spectrometry 1988;15(12):637-47.
1988: Axworthy Don; K J Hoffmann; A J Streeter; C J Calleman; G A Pascoe; Thomas A Baillie
Covalent binding of acetaminophen to mouse hemoglobin. Identification of major and minor adducts formed in vivo and implications for the nature of the arylating metabolites.
Chemico-biological interactions 1988;68(1-2):99-116.
1987: A W Rettenmeier; W P Gordon; H Barnes; Thomas A Baillie
Studies on the metabolic fate of valproic acid in the rat using stable isotope techniques.
Xenobiotica; the fate of foreign compounds in biological systems 1987;17(10):1147-57.
1987: Michael Threadgill; Axworthy Don; Thomas A Baillie; P B Farmer; K C Farrow; A Gescher; P Kestell; P G Pearson; A J Shaw
Metabolism of N-methylformamide in mice: primary kinetic deuterium isotope effect and identification of S-(N-methylcarbamoyl)glutathione as a metabolite.
The Journal of pharmacology and experimental therapeutics 1987;242(1):312-9.
1987: Larry K Keefer; A J Streeter; L Y Leung; W C Perry; H S Hu; Thomas A Baillie
Pharmacokinetic and deuterium isotope effect studies on the metabolism of formaldehyde and formate to carbon dioxide in rats in vivo.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(3):300-4.
1987: Allan E Rettie; A W Rettenmeier; William N Howald; Thomas A Baillie
Cytochrome P-450--catalyzed formation of delta 4-VPA, a toxic metabolite of valproic acid.
Science (New York, N.Y.) 1987;235(4791):890-3.
1986: L Y Leung; Thomas A Baillie
Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine.
Journal of medicinal chemistry 1986;29(11):2396-9.
1986: T A Moreland; J Astoin; F Lepage; F Tombret; René H Levy; Thomas A Baillie
The metabolic fate of stiripentol in man.
Drug metabolism and disposition: the biological fate of chemicals 1986;14(6):654-62.
1986: Allan E Rettie; A W Rettenmeier; B K Beyer; Thomas A Baillie; M R Juchau
Valproate hydroxylation by human fetal tissues and embryotoxicity of metabolites.
Clinical pharmacology and therapeutics 1986;40(2):172-7.
1986: A W Rettenmeier; W P Gordon; K S Prickett; René H Levy; Thomas A Baillie
Biotransformation and pharmacokinetics in the rhesus monkey of 2-n-propyl-4-pentenoic acid, a toxic metabolite of valproic acid.
Drug metabolism and disposition: the biological fate of chemicals 1986;14(4):454-64.
1986: A W Rettenmeier; W P Gordon; K S Prickett; René H Levy; J S Lockard; K E Thummel; Thomas A Baillie
Metabolic fate of valproic acid in the rhesus monkey. Formation of a toxic metabolite, 2-n-propyl-4-pentenoic acid.
Drug metabolism and disposition: the biological fate of chemicals 1986;14(4):443-53.
1985: S M Bjorge; Thomas A Baillie
Inhibition of medium-chain fatty acid beta-oxidation in vitro by valproic acid and its unsaturated metabolite, 2-n-propyl-4-pentenoic acid.
Biochemical and biophysical research communications 1985;132(1):245-52.
1985: K J Hoffmann; A J Streeter; Axworthy Don; Thomas A Baillie
Structural characterization of the major covalent adduct formed in vitro between acetaminophen and bovine serum albumin.
Chemico-biological interactions 1985;53(1-2):155-72.
1985: A W Rettenmeier; K S Prickett; W P Gordon; S M Bjorge; S L Chang; René H Levy; Thomas A Baillie
Studies on the biotransformation in the perfused rat liver of 2-n-propyl-4-pentenoic acid, a metabolite of the antiepileptic drug valproic acid. Evidence for the formation of chemically reactive intermediates.
Drug metabolism and disposition: the biological fate of chemicals 1985;13(1):81-96.
1984: A J Streeter; S M Bjorge; Axworthy Don; Sidney D Nelson; Thomas A Baillie
The microsomal metabolism and site of covalent binding to protein of 3'-hydroxyacetanilide, a nonhepatotoxic positional isomer of acetaminophen.
Drug metabolism and disposition: the biological fate of chemicals 1984;12(5):565-76.