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Christian Bailly
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Research Profile (preview)
Chemicals & Drugs
Phenomena
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Anatomy
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55
Colson, Pierre
48
Houssier, Claude
37
Lansiaux, Amélie
31
Hénichart, Jean-Pierre
30
Waring, Michael
26
Wilson, David W.
24
Baldeyrou, Brigitte
23
Laine, William
19
Pierré, Alain
19
Prudhomme, Michelle
17
Routier, Sylvain
17
Houssin, Raymond
17
Goossens, Jean-François
16
Léonce, Stéphane
16
Boykin, David
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All Publications
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2009: Vekhoff Pierre; Halby Ludovic; Oussedik Kahina; Dallavalle Sabrina; Merlini Lucio; Mahieu Christine; Lansiaux Amélie; Bailly Christian; Boutorine Alexandre; Pisano Claudio; Giannini Giuseppe; Alloatti Domenico; Arimondo Paola B
Optimized synthesis and enhanced efficacy of novel triplex-forming camptothecin derivatives based on gimatecan.
Bioconjugate chemistry 2009;20(4):666-72.
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2008: Bourderioux Aurélie; Bénéteau Valérie; Mérour Jean-Yves; Baldeyrou Brigitte; Ballot Caroline; Lansiaux Amélie; Bailly Christian; Le Guével Rémy; Guillouzo Christiane; Routier Sylvain
Synthesis and biological evaluation of novel oxophenylarcyriaflavins as potential anticancer agents.
Organic & biomolecular chemistry 2008;6(12):2108-17.
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2008: Jacquemard Ulrich; Dias Nathalie; Lansiaux Amélie; Bailly Christian; Logé Cédric; Robert Jean-Michel; Lozach Olivier; Meijer Laurent; Mérour Jean-Yves; Routier Sylvain
Synthesis of 3,5-bis(2-indolyl)pyridine and 3-[(2-indolyl)-5-phenyl]pyridine derivatives as CDK inhibitors and cytotoxic agents.
Bioorganic & medicinal chemistry 2008;16(9):4932-53.
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2007: Munde Manoj; Ismail Mohamed A; Arafa Reem; Peixoto Paul; Collar Catharine J; Liu Yang; Hu Laixing; David-Cordonnier Marie-Hélène; Lansiaux Amélie; Bailly Christian; Boykin David W; Wilson W David
Design of DNA minor groove binding diamidines that recognize GC base pair sequences: a dimeric-hinge interaction motif.
Journal of the American Chemical Society 2007;129(44):13732-43.
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2007: Hugon Bernadette; Anizon Fabrice; Bailly Christian; Golsteyn Roy M; Pierré Alain; Léonce Stéphane; Hickman John; Pfeiffer Bruno; Prudhomme Michelle
Synthesis and biological activities of isogranulatimide analogues.
Bioorganic & medicinal chemistry 2007;15(17):5965-80.
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2007: Lansiaux Amélie; Léonce Stéphane; Kraus-Berthier Laurence; Bal-Mahieu Christine; Mazinghien Romain; Didier Sébastien; David-Cordonnier Marie-Hélène; Hautefaye Patrick; Lavielle Gilbert; Bailly Christian; Hickman John A; Pierré Alain
Novel stable camptothecin derivatives replacing the E-ring lactone by a ketone function are potent inhibitors of topoisomerase I and promising antitumor drugs.
Molecular pharmacology 2007;72(2):311-9.
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2007: Negri Ana; Marco Esther; García-Hernández Verónica; Domingo Alberto; Llamas-Saiz Antonio L; Porto-Sandá Silvia; Riguera Ricardo; Laine William; David-Cordonnier Marie-Hélène; Bailly Christian; García-Fernández Luis F; Vaquero Juan José; Gago Federico
Antitumor activity, X-ray crystal structure, and DNA binding properties of thiocoraline A, a natural bisintercalating thiodepsipeptide.
Journal of medicinal chemistry 2007;50(14):3322-33.
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2007: Tanious Farial A; Laine William; Peixoto Paul; Bailly Christian; Goodwin Kristie D; Lewis Mark A; Long Eric C; Georgiadis Millie M; Tidwell Richard R; Wilson W David
Unusually strong binding to the DNA minor groove by a highly twisted benzimidazole diphenylether: induced fit and bound water.
Biochemistry 2007;46(23):6944-56.
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2007: Munde Manoj; Lee Michael; Neidle Stephen; Arafa Reem; Boykin David W; Liu Yang; Bailly Christian; Wilson W David
Induced fit conformational changes of a "reversed amidine" heterocycle: optimized interactions in a DNA minor groove complex.
Journal of the American Chemical Society 2007;129(17):5688-98.
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2006: Goossens Jean-François; Mahieu Christine; Dias Nathalie; Bailly Christian; Principe Paola; Bonte Jean-Paul; Lansiaux Amélie; Vaccher Claude; Foulon Catherine
Chiral capillary electrophoretic determination of the enantiomeric purity of homocamptothecin derivatives, promising antitumor topoisomerase I inhibitors, using highly sulfated CDs and fluorescence detection.
Electrophoresis 2006;27(23):4717-29.
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2006: Marco Esther; David-Cordonnier Marie-Hélène; Bailly Christian; Cuevas Carmen; Gago Federico
Further insight into the DNA recognition mechanism of trabectedin from the differential affinity of its demethylated analogue ecteinascidin ET729 for the triplet DNA binding site CGA.
Journal of medicinal chemistry 2006;49(23):6925-9.
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2006: David-Cordonnier Marie-Hélène; Casely-Hayford Maxwell; Kouach Mostafa; Briand Gilbert; Patterson Laurence H; Bailly Christian; Searcey Mark
Stereoselectivity, sequence specificity and mechanism of action of the azinomycin epoxide.
Chembiochem : a European journal of chemical biology 2006;7(11):1658-61.
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2006: Kluza Jérôme; Gallego Miguel-Angel; Loyens Anne; Beauvillain Jean-Claude; Sousa-Faro José-Maria Fernandez; Cuevas Carmen; Marchetti Philippe; Bailly Christian
Cancer cell mitochondria are direct proapoptotic targets for the marine antitumor drug lamellarin D.
Cancer research 2006;66(6):3177-87.
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2006: Kluza Jérôme; Mazinghien Romain; Irwin Helen; Hartley John A; Bailly Christian
Relationships between DNA strand breakage and apoptotic progression upon treatment of HL-60 leukemia cells with tafluposide or etoposide.
Anti-cancer drugs 2006;17(2):155-64.
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2006: Routier Sylvain; Mérour Jean-Yves; Dias Nathalie; Lansiaux Amélie; Bailly Christian; Lozach Olivier; Meijer Laurent
Synthesis and biological evaluation of novel phenylcarbazoles as potential anticancer agents.
Journal of medicinal chemistry 2006;49(2):789-99.
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2006: Arimondo Paola B; Thomas Craig J; Oussedik Kahina; Baldeyrou Brigitte; Mahieu Christine; Halby Ludovic; Guianvarc'h Dominique; Lansiaux Amélie; Hecht Sidney M; Bailly Christian; Giovannangeli Carine
Exploring the cellular activity of camptothecin-triple-helix-forming oligonucleotide conjugates.
Molecular and cellular biology 2006;26(1):324-33.
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2005: Dias Nathalie; Jacquemard Ulrich; Baldeyrou Brigitte; Lansiaux Amélie; Goossens Jean-François; Bailly Christian; Routier Sylvain; Mérour Jean-Yves
Synthesis of 2,6-diphenylpyrazine derivatives and their DNA binding and cytotoxic properties.
European journal of medicinal chemistry 2005;40(12):1206-13.
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2005: David-Cordonnier Marie-Hélène; Gajate Consuelo; Olmea Osvaldo; Laine William; de la Iglesia-Vicente Janis; Perez Carlos; Cuevas Carmen; Otero Gabriel; Manzanares Ignacio; Bailly Christian; Mollinedo Faustino
DNA and non-DNA targets in the mechanism of action of the antitumor drug trabectedin.
Chemistry & biology 2005;12(11):1201-10.
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2005: Kluza Jérôme; Mazinghien Romain; Degardin Klara; Lansiaux Amélie; Bailly Christian
Induction of apoptosis by the plant alkaloid sampangine in human HL-60 leukemia cells is mediated by reactive oxygen species.
European journal of pharmacology 2005;525(1-3):32-40.
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2005: Jacquemard Ulrich; Routier Sylvain; Dias Nathalie; Lansiaux Amélie; Goossens Jean-François; Bailly Christian; Mérour Jean-Yves
Synthesis of 2,5- and 3,5-diphenylpyridine derivatives for DNA recognition and cytotoxicity.
European journal of medicinal chemistry 2005;40(11):1087-95.
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2005: Doan Thi Mai Huong; Gaslonde Thomas; Michel Sylvie; Koch Michel; Tillequin François; Bailly Christian; David-Cordonnier Marie-Hélène; Pfeiffer Bruno; Léonce Stéphane; Pierré Alain
Design, synthesis, and cytotoxic activity of Michael acceptors and enol esters in the benzo[b]acronycine series.
Chemical & pharmaceutical bulletin 2005;53(8):919-22.
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2005: Dias Nathalie; Goossens Jean-François; Baldeyrou Brigitte; Lansiaux Amélie; Colson Pierre; Di Salvo Alberto; Bernal Jeanne; Turnbull Agnes; Mincher David J; Bailly Christian
Oxoazabenzo[de]anthracenes conjugated to amino acids: synthesis and evaluation as DNA-binding antitumor agents.
Bioconjugate chemistry 2005;16(4):949-58.
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2005: Dias Nathalie; Bailly Christian
Drugs targeting mitochondrial functions to control tumor cell growth.
Biochemical pharmacology 2005;70(1):1-12.
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2005: Marco Esther; Laine William; Tardy Christelle; Lansiaux Amélie; Iwao Masatomo; Ishibashi Fumito; Bailly Christian; Gago Federico
Molecular determinants of topoisomerase I poisoning by lamellarins: comparison with camptothecin and structure-activity relationships.
Journal of medicinal chemistry 2005;48(11):3796-807.
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2005: Vanhuyse Marie; Kluza Jérôme; Tardy Christèle; Otero Gabriel; Cuevas Carmen; Bailly Christian; Lansiaux Amélie
Lamellarin D: a novel pro-apoptotic agent from marine origin insensitive to P-glycoprotein-mediated drug efflux.
Cancer letters 2005;221(2):165-75.
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2005: Tazi Jamal; Bakkour Nadia; Soret Johann; Zekri Latifa; Hazra Banasri; Laine William; Baldeyrou Brigitte; Lansiaux Amélie; Bailly Christian
Selective inhibition of topoisomerase I and various steps of spliceosome assembly by diospyrin derivatives.
Molecular pharmacology 2005;67(4):1186-94.
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2005: Arimondo Paola B; Laco Gary S; Thomas Craig J; Halby Ludovic; Pez Didier; Schmitt Philippe; Boutorine Alexandre; Garestier Thérèse; Pommier Yves; Hecht Sidney M; Sun Jian-Sheng; Bailly Christian
Activation of camptothecin derivatives by conjugation to triple helix-forming oligonucleotides.
Biochemistry 2005;44(11):4171-80.
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2005: Routier Sylvain; Peixoto Paul; Mérour Jean-Yves; Coudert Gérard; Dias Nathalie; Bailly Christian; Pierré Alain; Léonce Stéphane; Caignard Daniel-Henry
Synthesis and biological evaluation of novel naphthocarbazoles as potential anticancer agents.
Journal of medicinal chemistry 2005;48(5):1401-13.
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2005: Bailly Christian; Arafa Reem K; Tanious Farial A; Laine William; Tardy Christèle; Lansiaux Amélie; Colson Pierre; Boykin David W; Wilson W David
Molecular determinants for DNA minor groove recognition: design of a bis-guanidinium derivative of ethidium that is highly selective for AT-rich DNA sequences.
Biochemistry 2005;44(6):1941-52.
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2005: David-Cordonnier Marie-Hélène; Laine William; Lansiaux Amélie; Rosu Frédéric; Colson Pierre; de Pauw Edwin; Michel Sylvie; Tillequin Francois; Koch Michel; Hickman John A; Pierré Alain; Bailly Christian
Covalent binding of antitumor benzoacronycines to double-stranded DNA induces helix opening and the formation of single-stranded DNA: unique consequences of a novel DNA-bonding mechanism.
Molecular cancer therapeutics 2005;4(1):71-80.
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2005: Bailly Christian; Kluza Jérôme; Martin Christopher; Ellis Thomas; Waring Michael J
DNase I footprinting of small molecule binding sites on DNA.
Methods in molecular biology (Clifton, N.J.) 2005;288():319-42.
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2004: Dias Nathalie; Jacquemard Ulrich; Baldeyrou Brigitte; Tardy Christelle; Lansiaux Amélie; Colson Pierre; Tanious Farial; Wilson W David; Routier Sylvain; Mérour Jean-Yves; Bailly Christian
Targeting DNA with novel diphenylcarbazoles.
Biochemistry 2004;43(48):15169-78.
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2004: Bal Christine; Baldeyrou Brigitte; Moz Florence; Lansiaux Amélie; Colson Pierre; Kraus-Berthier Laurence; Léonce Stéphane; Pierré Alain; Boussard Marie-Françoise; Rousseau Anne; Wierzbicki Michel; Bailly Christian
Novel antitumor indenoindole derivatives targeting DNA and topoisomerase II.
Biochemical pharmacology 2004;68(10):1911-22.
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2004: Mallena Sirish; Lee Michael P H; Bailly Christian; Neidle Stephen; Kumar Arvind; Boykin David W; Wilson W David
Thiophene-based diamidine forms a "super" at binding minor groove agent.
Journal of the American Chemical Society 2004;126(42):13659-69.
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2004: Kluza Jérôme; Marchetti Philippe; Gallego Miguel-Angel; Lancel Steve; Fournier Charles; Loyens Anne; Beauvillain Jean-Claude; Bailly Christian
Mitochondrial proliferation during apoptosis induced by anticancer agents: effects of doxorubicin and mitoxantrone on cancer and cardiac cells.
Oncogene 2004;23(42):7018-30.
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2004: Catoen-Chackal Sarah; Facompré Michael; Houssin Raymond; Pommery Nicole; Goossens Jean-François; Colson Pierre; Bailly Christian; Hénichart Jean-Pierre
DNA binding to guide the development of tetrahydroindeno[1,2-b]pyrido[4,3,2-de]quinoline derivatives as cytotoxic agents.
Journal of medicinal chemistry 2004;47(14):3665-73.
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2004: Prado Soizic; Michel Sylvie; Tillequin François; Koch Michel; Pfeiffer Bruno; Pierré Alain; Léonce Stéphane; Colson Pierre; Baldeyrou Brigitte; Lansiaux Amélie; Bailly Christian
Synthesis and cytotoxic activity of benzo[c][1,7] and [1,8]phenanthrolines analogues of nitidine and fagaronine.
Bioorganic & medicinal chemistry 2004;12(14):3943-53.
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2004: Jacquemard Ulrich; Routier Sylvain; Tatibouët Arnaud; Kluza Jérôme; Laine William; Bal Christine; Bailly Christian; Mérour Jean-Yves
Synthesis of diphenylcarbazoles as cytotoxic DNA binding agents.
Organic & biomolecular chemistry 2004;2(10):1476-83.
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2004: Voldoire Aline; Moreau Pascale; Sancelme Martine; Matulova Maria; Léonce Stéphane; Pierré Alain; Hickman John; Pfeiffer Bruno; Renard Pierre; Dias Nathalie; Bailly Christian; Prudhomme Michelle
Analogues of antifungal tjipanazoles from rebeccamycin.
Bioorganic & medicinal chemistry 2004;12(8):1955-62.
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2004: Tardy Christelle; Facompré Michaël; Laine William; Baldeyrou Brigitte; García-Gravalos Dolores; Francesch Andrés; Mateo Cristina; Pastor Alfredo; Jiménez José A; Manzanares Ignacio; Cuevas Carmen; Bailly Christian
Topoisomerase I-mediated DNA cleavage as a guide to the development of antitumor agents derived from the marine alkaloid lamellarin D: triester derivatives incorporating amino acid residues.
Bioorganic & medicinal chemistry 2004;12(7):1697-712.
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2004: Verquin Géraldine; Fontaine Gaëlle; Bria Marc; Zhilinskaya Elena; Abi-Aad Edmond; Aboukaïs Antoine; Baldeyrou Brigitte; Bailly Christian; Bernier Jean-Luc
DNA modification by oxovanadium(IV) complexes of salen derivatives.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(3):345-53.
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2004: David-Cordonnier Marie-Hélène; Laine William; Gaslonde Thomas; Michel Sylvie; Tillequin Francois; Koch Michel; Léonce Stéphane; Pierré Alain; Bailly Christian
Design of novel antitumor DNA alkylating agents: the benzacronycine series.
Current medicinal chemistry. Anti-cancer agents 2004;4(2):83-92.
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2004: Blanchard Stéphanie; Rodriguez Ivan; Tardy Christelle; Baldeyrou Brigitte; Bailly Christian; Colson Pierre; Houssier Claude; Léonce Stéphane; Kraus-Berthier Laurence; Pfeiffer Bruno; Renard Pierre; Pierré Alain; Caubère Paul; Guillaumet Gérald
Synthesis of mono- and bisdihydrodipyridopyrazines and assessment of their DNA binding and cytotoxic properties.
Journal of medicinal chemistry 2004;47(4):978-87.
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2004: Nguyen Binh; Hamelberg Donald; Bailly Christian; Colson Pierre; Stanek Jaroslav; Brun Reto; Neidle Stephen; Wilson W David
Characterization of a novel DNA minor-groove complex.
Biophysical journal 2004;86(2):1028-41.
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2004: Malecki Natacha; Carato Pascal; Rigo Benoît; Goossens Jean-François; Houssin Raymond; Bailly Christian; Hénichart Jean-Pierre
Synthesis of condensed quinolines and quinazolines as DNA ligands.
Bioorganic & medicinal chemistry 2004;12(3):641-7.
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2004: Solier Stéphanie; Lansiaux Amélie; Logette Emmanuelle; Wu Jane; Soret Johann; Tazi Jamal; Bailly Christian; Desoche Lydie; Solary Eric; Corcos Laurent
Topoisomerase I and II inhibitors control caspase-2 pre-messenger RNA splicing in human cells.
Molecular cancer research : MCR 2004;2(1):53-61.
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2004: Tanious Farial A; Hamelberg Donald; Bailly Christian; Czarny Agnieska; Boykin David W; Wilson W David
DNA sequence dependent monomer-dimer binding modulation of asymmetric benzimidazole derivatives.
Journal of the American Chemical Society 2004;126(1):143-53.
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2004: David-Cordonnier Marie Hélène; Laine William; Kouach Mostafa; Briand Gilbert; Vezin Hervé; Gaslonde Thomas; Michel Sylvie; Doan Thi Mai Huong; Tillequin Francois; Koch Michel; Léonce Stéphane; Pierré Alain; Bailly Christian
A transesterification reaction is implicated in the covalent binding of benzo[b]acronycine anticancer agents with DNA and glutathion.
Bioorganic & medicinal chemistry 2004;12(1):23-9.
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2004: Huyghe Pauline; Dassonneville Laurent; Fenaux Pierre; Bailly Christian
Hydroxyurea-induced apoptosis in an EBV-immortalized lymphoblastoid cell line.
Oncology research 2004;14(4-5):235-45.
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2003: Kluza Jérôme; Clark Alice M; Bailly Christian
Apoptosis induced by the alkaloid sampangine in HL-60 leukemia cells: correlation between the effects on the cell cycle progression and changes of mitochondrial potential.
Annals of the New York Academy of Sciences 2003;1010():331-4.
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2003: Kluza Jérôme; Baldeyrou Brigitte; Colson Pierre; Rasoanaivo Philippe; Mambu Lengo; Frappier François; Bailly Christian
Cytotoxicity and DNA binding properties of the plant alkaloid burasaine.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2003;20(4-5):383-91.
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2003: Bailly Christian; Bal Christine; Barbier Pascale; Combes Sébastien; Finet Jean-Pierre; Hildebrand Marie-Paule; Peyrot Vincent; Wattez Nicole
Synthesis and biological evaluation of 4-arylcoumarin analogues of combretastatins.
Journal of medicinal chemistry 2003;46(25):5437-44.
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2003: Tanious Farial; Wilson W David; Wang Lei; Kumar Arvind; Boykin David W; Marty Carine; Baldeyrou Brigitte; Bailly Christian
Cooperative dimerization of a heterocyclic diamidine determines sequence-specific DNA recognition.
Biochemistry 2003;42(46):13576-86.
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2003: Facompré Michaël; Tardy Christelle; Bal-Mahieu Christine; Colson Pierre; Perez Carlos; Manzanares Ignacio; Cuevas Carmen; Bailly Christian
Lamellarin D: a novel potent inhibitor of topoisomerase I.
Cancer research 2003;63(21):7392-9.
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2003: Moreau Pascale; Gaillard Nathalie; Marminon Christelle; Anizon Fabrice; Dias Nathalie; Baldeyrou Brigitte; Bailly Christian; Pierré Alain; Hickman John; Pfeiffer Bruno; Renard Pierre; Prudhomme Michelle
Semi-synthesis, topoisomerase I and kinases inhibitory properties, and antiproliferative activities of new rebeccamycin derivatives.
Bioorganic & medicinal chemistry 2003;11(23):4871-9.
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2003: Carrasco Carolina; Joubert Alexandra; Tardy Christelle; Maestre Nicolas; Cacho Monica; Braña Miguel F; Bailly Christian
DNA sequence recognition by bispyrazinonaphthalimides antitumor agents.
Biochemistry 2003;42(40):11751-61.
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2003: Anizon Fabrice; Moreau Pascale; Sancelme Martine; Laine William; Bailly Christian; Prudhomme Michelle
Rebeccamycin analogues bearing amine substituents or other groups on the sugar moiety.
Bioorganic & medicinal chemistry 2003;11(17):3709-22.
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2003: Hautefaye Patrick; Cimetière Bernard; Pierré Alain; Léonce Stéphane; Hickman John; Laine William; Bailly Christian; Lavielle Gilbert
Synthesis and pharmacological evaluation of novel non-lactone analogues of camptothecin.
Bioorganic & medicinal chemistry letters 2003;13(16):2731-5.
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2003: Arimondo Paola B; Angenault Stéphane; Halby Ludovic; Boutorine Alexandre; Schmidt Frédéric; Monneret Claude; Garestier Thérèse; Sun Jian-Sheng; Bailly Christian; Hélène Claude
Spatial organization of topoisomerase I-mediated DNA cleavage induced by camptothecin-oligonucleotide conjugates.
Nucleic acids research 2003;31(14):4031-40.
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2003: Thi Mai Huong Doan; Gaslonde Thomas; Michel Sylvie; Tillequin François; Koch Michel; Bongui Jean-Bernard; Elomri Abdelhakim; Seguin Elisabeth; Pfeiffer Bruno; Renard Pierre; David-Cordonnier Marie-Hélène; Laine William; Bailly Christian; Kraus-Berthier Laurence; Léonce Stéphane; Hickman John A; Pierré Alain
Structure-activity relationships and mechanism of action of antitumor benzo[b]pyrano[3,2-h]acridin-7-one acronycine analogues.
Journal of medicinal chemistry 2003;46(14):3072-82.
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2003: David-Cordonnier Marie-Hélène; Laine William; Joubert Alexandra; Tardy Christelle; Goossens Jean-François; Kouach Mostafa; Briand Gilbert; Thi Mai Huong Doan; Michel Sylvie; Tillequin Francois; Koch Michel; Leonce Stéphane; Pierre Alain; Bailly Christian
Covalent binding to glutathione of the DNA-alkylating antitumor agent, S23906-1.
European journal of biochemistry / FEBS 2003;270(13):2848-59.
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2003: Mimeault Murielle; Pommery Nicole; Wattez Nicole; Bailly Christian; Hénichart Jean-Pierre
Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production.
The Prostate 2003;56(1):1-12.
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2003: Joubert Alexandra; Sun Xiao-Wen; Johansson Eric; Bailly Christian; Mann John; Neidle Stephen
Sequence-selective targeting of long stretches of the DNA minor groove by a novel dimeric bis-benzimidazole.
Biochemistry 2003;42(20):5984-92.
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2003: Facompré Michaël; Carrasco Carolina; Vezin Hervé; Chisholm John D; Yoburn Joshua C; Van Vranken David L; Bailly Christian
Indolocarbazole glycosides in inactive conformations.
Chembiochem : a European journal of chemical biology 2003;4(5):386-95.
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2003: Perzyna Aurore; Houssin Raymond; Goossens Jean-François; Pommery Nicole; Marty Carine; Facompré Michael; Colson Pierre; Houssier Claude; Bailly Christian; Hénichart Jean-Pierre
Indolizino[1,2-b]quinolines derived from A-D rings of camptothecin: synthesis and DNA interaction.
Journal of enzyme inhibition and medicinal chemistry 2003;18(2):101-9.
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2003: Bailly Christian; Carrasco Carolina; Joubert Alexandra; Bal Christine; Wattez Nicole; Hildebrand Marie-Paule; Lansiaux Amélie; Colson Pierre; Houssier Claude; Cacho Monica; Ramos Ana; Braña Miguel F
Chromophore-modified bisnaphthalimides: DNA recognition, topoisomerase inhibition, and cytotoxic properties of two mono- and bisfuronaphthalimides.
Biochemistry 2003;42(14):4136-50.
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2003: Charmantray Franck; Demeunynck Martine; Carrez Danièle; Croisy Alain; Lansiaux Amélie; Bailly Christian; Colson Pierre
4-Hydroxymethyl-3-aminoacridine derivatives as a new family of anticancer agents.
Journal of medicinal chemistry 2003;46(6):967-77.
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2003: Chackal Sarah; Facompré Michael; Houssin Raymond; Goossens Jean-François; Pommery Nicole; Hénichart Jean-Pierre; Bailly Christian
Highly cytotoxic benzo[c]pyrido[2,3,4-kl]acridines.
Bioorganic & medicinal chemistry letters 2003;13(5):943-6.
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2003: Bailly Christian; Chessari Gianni; Carrasco Carolina; Joubert Alexandra; Mann John; Wilson W David; Neidle Stephen
Sequence-specific minor groove binding by bis-benzimidazoles: water molecules in ligand recognition.
Nucleic acids research 2003;31(5):1514-24.
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2003: Braña Miguel F; Cacho Mónica; Ramos Ana; Domínguez M Teresa; Pozuelo Jose M; Abradelo Cristina; Rey-Stolle M Fernanda; Yuste Mercedes; Carrasco Carolina; Bailly Christian
Synthesis, biological evaluation and DNA binding properties of novel mono and bisnaphthalimides.
Organic & biomolecular chemistry 2003;1(4):648-54.
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2003: Marminon Christelle; Pierré Alain; Pfeiffer Bruno; Pérez Valérie; Léonce Stéphane; Joubert Alexandra; Bailly Christian; Renard Pierre; Hickman John; Prudhomme Michelle
Syntheses and antiproliferative activities of 7-azarebeccamycin analogues bearing one 7-azaindole moiety.
Journal of medicinal chemistry 2003;46(4):609-22.
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2003: Bailly Christian; Guerniou Valérie; Lamour Eric; Bernier Jean-Luc; Villain Françoise; Vezin Hervé
Site-specific cleavage of the HIV-1 TAR RNA by a hydroxysalen-copper(III) complex.
Chembiochem : a European journal of chemical biology 2003;4(1):112-4.
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2003: Carrasco Carolina; Helissey Philippe; Haroun Michelyne; Baldeyrou Brigitte; Lansiaux Amélie; Colson Pierre; Houssier Claude; Giorgi-Renault Sylviane; Bailly Christian
Design of a composite ethidium-netropsin-anilinoacridine molecule for DNA recognition.
Chembiochem : a European journal of chemical biology 2003;4(1):50-61.
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2003: Goossens Jean-François; Kluza Jérôme; Vezin Hervé; Kouach Mustapha; Briand Gilbert; Baldeyrou Brigitte; Wattez Nicole; Bailly Christian
Plasma stability of two glycosyl indolocarbazole antitumor agents.
Biochemical pharmacology 2003;65(1):25-34.
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2002: Facompré Michaël; Baldeyrou Brigitte; Bailly Christian; Anizon Fabrice; Marminon Christelle; Prudhomme Michelle; Colson Pierre; Houssier Claude
DNA targeting of two new antitumour rebeccamycin derivatives.
European journal of medicinal chemistry 2002;37(12):925-32.
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2002: Lansiaux Amélie; Tanious Farial; Mishal Zohar; Dassonneville Laurent; Kumar Arvind; Stephens Chad E; Hu Qiyue; Wilson W David; Boykin David W; Bailly Christian
Distribution of furamidine analogues in tumor cells: targeting of the nucleus or mitochondria depending on the amidine substitution.
Cancer research 2002;62(24):7219-29.
-
2002: Perzyna Aurore; Marty Carine; Facompré Michael; Goossens Jean-François; Pommery Nicole; Colson Pierre; Houssier Claude; Houssin Raymond; Hénichart Jean-Pierre; Bailly Christian
Formaldehyde-induced DNA cross-link of indolizino[1,2-b]quinolines derived from the A-D rings of camptothecin.
Journal of medicinal chemistry 2002;45(26):5809-12.
-
2002: Carrasco Carolina; Rosu Frédéric; Gabelica Valérie; Houssier Claude; De Pauw Edwin; Garbay-Jaureguiberry Christiane; Roques Bernard; Wilson W David; Chaires Jonathan B; Waring Michael J; Bailly Christian
Tight binding of the antitumor drug ditercalinium to quadruplex DNA.
Chembiochem : a European journal of chemical biology 2002;3(12):1235-41.
-
2002: Vezin Hervé; Lamour Eric; Routier Sylvain; Villain Françoise; Bailly Christian; Bernier Jean Luc; Catteau Jean Pierre
Free radical production by hydroxy-salen manganese complexes studied by ESR and XANES.
Journal of inorganic biochemistry 2002;92(3-4):177-82.
-
2002: Nguyen Binh; Lee Michael P H; Hamelberg Donald; Joubert Alexandra; Bailly Christian; Brun Reto; Neidle Stephen; Wilson W David
Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove.
Journal of the American Chemical Society 2002;124(46):13680-1.
-
2002: Facompre Michaël; Carrasco Carolina; Colson Pierre; Houssier Claude; Chisholm John D; Van Vranken David L; Bailly Christian
DNA binding and topoisomerase I poisoning activities of novel disaccharide indolocarbazoles.
Molecular pharmacology 2002;62(5):1215-27.
-
2002: David-Cordonnier Marie-Hélène; Laine William; Lansiaux Amélie; Kouach Mostafa; Briand Gilbert; Pierré Alain; Hickman John A; Bailly Christian
Alkylation of guanine in DNA by S23906-1, a novel potent antitumor compound derived from the plant alkaloid acronycine.
Biochemistry 2002;41(31):9911-20.
-
2002: Jonckers Tim H M; van Miert Sabine; Cimanga Kanyanga; Bailly Christian; Colson Pierre; De Pauw-Gillet Marie-Claire; van den Heuvel Hilde; Claeys Magda; Lemière Filip; Esmans Eddy L; Rozenski Jef; Quirijnen Ludo; Maes Louis; Dommisse Roger; Lemière Guy L F; Vlietinck Arnold; Pieters Luc
Synthesis, cytotoxicity, and antiplasmodial and antitrypanosomal activity of new neocryptolepine derivatives.
Journal of medicinal chemistry 2002;45(16):3497-508.
-
2002: Lansiaux Amélie; Bailly Christian; Houssier Claude; Colson Pierre; De Pauw-Gillet Marie-Claire; Frédérich Michel; Tits Monique; Angenot Luc
Apoptosis of HL-60 leukemia cells induced by the bisindole alkaloids sungucine and isosungucine from Strychnos icaja.
Planta medica 2002;68(7):591-5.
-
2002: Crow Stephen D G; Bailly Christian; Garbay-Jaureguiberry Christiane; Roques Bernard; Shaw Barbara Ramsay; Waring Michael J
DNA sequence recognition by the antitumor drug ditercalinium.
Biochemistry 2002;41(27):8672-82.
-
2002: Marminon Christelle; Facompré Michaël; Bailly Christian; Hickman John; Pierré Alain; Pfeiffer Bruno; Renard Pierre; Prudhomme Michelle
Dimers from dechlorinated rebeccamycin: synthesis, interaction with DNA, and antiproliferative activities.
European journal of medicinal chemistry 2002;37(5):435-40.
-
2002: Lansiaux Amélie; Dassonneville Laurent; Facompré Michaël; Kumar Arvind; Stephens Chad E; Bajic Miroslav; Tanious Farial; Wilson W David; Boykin David W; Bailly Christian
Distribution of furamidine analogues in tumor cells: influence of the number of positive charges.
Journal of medicinal chemistry 2002;45(10):1994-2002.
-
2002: Kluza Jérôme; Lansiaux Amélie; Wattez Nicole; Hildebrand Marie-Paule; Léonce Stéphane; Pierré Alain; Hickman John A; Bailly Christian
Induction of apoptosis in HL-60 leukemia and B16 melanoma cells by the acronycine derivative S23906-1.
Biochemical pharmacology 2002;63(8):1443-52.
-
2002: Baldeyrou Brigitte; Tardy Christelle; Bailly Christian; Colson Pierre; Houssier Claude; Charmantray Franck; Demeunynck Martine
Synthesis and DNA interaction of a mixed proflavine-phenanthroline Tröger base.
European journal of medicinal chemistry 2002;37(4):315-22.
-
2002: Carrasco Carolina; Facompré Michaël; Chisholm John D; Van Vranken David L; Wilson W David; Bailly Christian
DNA sequence recognition by the indolocarbazole antitumor antibiotic AT2433-B1 and its diastereoisomer.
Nucleic acids research 2002;30(8):1774-81.
-
2002: Nguyen Binh; Tardy Christelle; Bailly Christian; Colson Pierre; Houssier Claude; Kumar Arvind; Boykin David W; Wilson W David
Influence of compound structure on affinity, sequence selectivity, and mode of binding to DNA for unfused aromatic dications related to furamidine.
Biopolymers 2002;63(5):281-97.
-
2002: Wang Lei; Kumar Arvind; Boykin David W; Bailly Christian; Wilson W David
Comparative thermodynamics for monomer and dimer sequence-dependent binding of a heterocyclic dication in the DNA minor groove.
Journal of molecular biology 2002;317(3):361-74.
-
2001: Moreau P; Sancelme M; Bailly C; Léonce S; Pierré A; Hickman J; Pfeiffer B; Prudhomme M
Synthesis and biological activities of indolocarbazoles bearing amino acid residues.
European journal of medicinal chemistry 2001;36(11-12):887-97.
-
2001: Arimondo P B; Baldeyrou B; Laine W; Bal C; Alphonse F A; Routier S; Coudert G; Mérour J Y; Colson P; Houssier C; Bailly C
DNA interaction and cytotoxicity of a new series of indolo[2,3-b]quinoxaline and pyridopyrazino[2,3-b]indole derivatives.
Chemico-biological interactions 2001;138(1):59-75.
-
2001: Pilch B; Allemand E; Facompré M; Bailly C; Riou J F; Soret J; Tazi J
Specific inhibition of serine- and arginine-rich splicing factors phosphorylation, spliceosome assembly, and splicing by the antitumor drug NB-506.
Cancer research 2001;61(18):6876-84.
-
2001: Lansiaux A; Facompré M; Wattez N; Hildebrand M P; Bal C; Demarquay D; Lavergne O; Bigg D C; Bailly C
Apoptosis induced by the homocamptothecin anticancer drug BN80915 in HL-60 cells.
Molecular pharmacology 2001;60(3):450-61.
-
2001: Bilik P; Tanious F; Kumar A; Wilson W D; Boykin D W; Colson P; Houssier C; Facompré M; Tardy C; Bailly C
Novel dications with unfused aromatic systems: trithiophene and trifuran derivatives of furimidazoline.
Chembiochem : a European journal of chemical biology 2001;2(7-8):559-69.
-
2001: Bailly C; Tardy C; Wang L; Armitage B; Hopkins K; Kumar A; Schuster G B; Boykin D W; Wilson W D
Recognition of ATGA sequences by the unfused aromatic dication DB293 forming stacked dimers in the DNA minor groove.
Biochemistry 2001;40(33):9770-9.
-
2001: Tanious F A; Wilson W D; Patrick D A; Tidwell R R; Colson P; Houssier C; Tardy C; Bailly C
Sequence-dependent binding of bis-amidine carbazole dications to DNA.
European journal of biochemistry / FEBS 2001;268(12):3455-64.
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2001: Joseph B; Facompré M; Da Costa H; Routier S; Mérour J Y; Colson P; Houssier C; Bailly C
Synthesis, cytotoxicity, DNA interaction and topoisomerase II inhibition properties of tetrahydropyrrolo[3,4-a]carbazole-1,3-dione and tetrahydropyrido-[3,2-b]pyrrolo[3,4-g]indole-1,3-dione derivatives.
Bioorganic & medicinal chemistry 2001;9(6):1533-41.
-
2001: Carrasco C; Vezin H; Wilson W D; Ren J; Chaires J B; Bailly C
DNA binding properties of the indolocarbazole antitumor drug NB-506.
Anti-cancer drug design 2001;16(2-3):99-107.
-
2001: Goossens J F; Bouey-Bencteux E; Houssin R; Hénichart J P; Colson P; Houssier C; Laine W; Baldeyrou B; Bailly C
DNA interaction of the tyrosine protein kinase inhibitor PD153035 and its N-methyl analogue.
Biochemistry 2001;40(15):4663-71.
-
2001: Bailly C; Laine W; Baldeyrou B; Demarquay D; Huchet M; Coulomb H; Lanco C; Lavergne O; Bigg D C
A novel B-ring modified homocamptothecin, 12-Cl-hCPT, showing antiproliferative and topoisomerase I inhibitory activities superior to SN-38.
Anti-cancer drug design 2001;16(1):27-36.
-
2001: Wang L; Carrasco C; Kumar A; Stephens C E; Bailly C; Boykin D W; Wilson W D
Evaluation of the influence of compound structure on stacked-dimer formation in the DNA minor groove.
Biochemistry 2001;40(8):2511-21.
-
2001: Voldoire A; Sancelme M; Prudhomme M; Colson P; Houssier C; Bailly C; Léonce S; Lambel S
Rebeccamycin analogues from indolo[2,3-c]carbazole.
Bioorganic & medicinal chemistry 2001;9(2):357-65.
-
2001: Facompre M; Goossens J F; Bailly C
Apoptotic response of HL-60 human leukemia cells to the antitumor drug NB-506, a glycosylated indolocarbazole inhibitor of topoisomerase 1.
Biochemical pharmacology 2001;61(3):299-310.
-
2001: Li K; Davis T M; Bailly C; Kumar A; Boykin D W; Wilson W D
A heterocyclic inhibitor of the REV-RRE complex binds to RRE as a dimer.
Biochemistry 2001;40(5):1150-8.
-
2001: Lansiaux A; Bras-Goncalves R A; Rosty C; Laurent-Puig P; Poupon M F; Bailly C
Topoisomerase I-DNA covalent complexes in human colorectal cancer xenografts with different p53 and microsatellite instability status: relation with their sensitivity to CTP-11.
Anticancer research 2001;21(1A):471-6.
-
2001: Demarquay D; Huchet M; Coulomb H; Lesueur-Ginot L; Lavergne O; Kasprzyk P G; Bailly C; Camara J; Bigg D C
The homocamptothecin BN 80915 is a highly potent orally active topoisomerase I poison.
Anti-cancer drugs 2001;12(1):9-19.
-
2001: Urasaki Y; Laco G; Takebayashi Y; Bailly C; Kohlhagen G; Pommier Y
Use of camptothecin-resistant mammalian cell lines to evaluate the role of topoisomerase I in the antiproliferative activity of the indolocarbazole, NB-506, and its topoisomerase I binding site.
Cancer research 2001;61(2):504-8.
-
2001: Lansiaux A; Laine W; Baldeyrou B; Mahieu C; Wattez N; Vezin H; Martinez F J; Piñeyro A; Bailly C
DNA topoisomerase II inhibition by peroxisomicine A(1) and its radical metabolite induces apoptotic cell death of HL-60 and HL-60/MX2 human leukemia cells.
Chemical research in toxicology 2001;14(1):16-24.
-
2000: Arimondo P; Boukarim C; Bailly C; Dauzonne D; Monneret C
Design of two etoposide-amsacrine conjugates: topoisomerase II and tubuline polymerization inhibition and relation to cytotoxicity.
Anti-cancer drug design 2000;15(6):413-21.
-
2000: Dassonneville L; Lansiaux A; Wattelet A; Wattez N; Mahieu C; Van Miert S; Pieters L; Bailly C
Cytotoxicity and cell cycle effects of the plant alkaloids cryptolepine and neocryptolepine: relation to drug-induced apoptosis.
European journal of pharmacology 2000;409(1):9-18.
-
2000: Bailly C; Goossens J F; Laine W; Anizon F; Prudhomme M; Ren J; Chaires J B
Formaldehyde-induced alkylation of a 2'-aminoglucose rebeccamycin derivative to both A.T and G.C base pairs in DNA.
Journal of medicinal chemistry 2000;43(24):4711-20.
-
2000: Tanious F A; Ding D; Patrick D A; Bailly C; Tidwell R R; Wilson W D
Effects of compound structure on carbazole dication-DNA complexes: tests of the minor-groove complex models.
Biochemistry 2000;39(39):12091-101.
-
2000: Benoit J; Routier S; Mérour J Y; Colson P; Houssier C; Bailly C
DNA but not topoisomerases is a target for a cytotoxic benzo[5,6]cyclohepta[b]indol-6-one derivative.
Anticancer research 2000;20(5A):3307-14.
-
2000: Bailly C; Crow S; Minnock A; Waring M J
DNA recognition by quinoline antibiotics: use of base-modified DNA molecules to investigate determinants of sequence-specific binding of luzopeptin.
Nucleosides, nucleotides & nucleic acids 2000;19(8):1337-53.
-
2000: Kluza J; Lansiaux A; Wattez N; Mahieu C; Osheroff N; Bailly C
Apoptotic response of HL-60 human leukemia cells to the antitumor drug TAS-103.
Cancer research 2000;60(15):4077-84.
-
2000: Dassonneville L; Wattez N; Baldeyrou B; Mahieu C; Lansiaux A; Banaigs B; Bonnard I; Bailly C
Inhibition of topoisomerase II by the marine alkaloid ascididemin and induction of apoptosis in leukemia cells.
Biochemical pharmacology 2000;60(4):527-37.
-
2000: Facompré M; Wattez N; Kluza J; Lansiaux A; Bailly C
Relationship between cell cycle changes and variations of the mitochondrial membrane potential induced by etoposide.
Molecular cell biology research communications : MCBRC 2000;4(1):37-42.
-
2000: Bailly C; Laine W; Demeunynck M; Lhomme J
Enantiospecific recognition of DNA sequences by a proflavine Tröger base.
Biochemical and biophysical research communications 2000;273(2):681-5.
-
2000: Bailly C; Laine W; Baldeyrou B; De Pauw-Gillet M C; Colson P; Houssier C; Cimanga K; Van Miert S; Vlietinck A J; Pieters L
DNA intercalation, topoisomerase II inhibition and cytotoxic activity of the plant alkaloid neocryptolepine.
Anti-cancer drug design 2000;15(3):191-201.
-
2000: Lavergne O; Demarquay D; Bailly C; Lanco C; Rolland A; Huchet M; Coulomb H; Muller N; Baroggi N; Camara J; Le Breton C; Manginot E; Cazaux J B; Bigg D C
Topoisomerase I-mediated antiproliferative activity of enantiomerically pure fluorinated homocamptothecins.
Journal of medicinal chemistry 2000;43(11):2285-9.
-
2000: Goossens J F; Hénichart J P; Dassonneville L; Facompré M; Bailly C
Relation between intracellular acidification and camptothecin-induced apoptosis in leukemia cells.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;10(2):125-31.
-
2000: Ren J; Bailly C; Chaires J B
NB-506, an indolocarbazole topoisomerase I inhibitor, binds preferentially to triplex DNA.
FEBS letters 2000;470(3):355-9.
-
2000: Dudouit F; Goossens J F; Houssin R; Hénichart J P; Colson P; Houssier C; Gelus N; Bailly C
Synthesis, DNA binding, topoisomerases inhibition and cytotoxic properties of 4-arylcarboxamidopyrrolo-2-carboxyanilides.
Bioorganic & medicinal chemistry letters 2000;10(6):553-7.
-
2000: Helissey P; Giorgi-Renault S; Colson P; Houssier C; Bailly C
Sequence-recognition and cleavage of DNA by a netropsin-phenazine-di-N-oxide conjugate.
Bioconjugate chemistry 2000;11(2):219-27.
-
2000: Goossens J F; Hénichart J P; Anizon F; Prudhomme M; Dugave C; Riou J; Bailly C
Cellular uptake and interaction with purified membranes of rebeccamycin derivatives.
European journal of pharmacology 2000;389(2-3):141-6.
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2000: Wang L; Bailly C; Kumar A; Ding D; Bajic M; Boykin D W; Wilson W D
Specific molecular recognition of mixed nucleic acid sequences: an aromatic dication that binds in the DNA minor groove as a dimer.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(1):12-6.
-
1999: Minnock A; Crow S; Bailly C; Waring M J
The influence of the exocyclic pyrimidine 5-methyl group on DNAse I cleavage and sequence recognition by drugs.
Biochimica et biophysica acta 1999;1489(2-3):233-48.
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1999: Dassonneville L; Wattez N; Mahieu C; Colson P; Houssier C; Frederich M; Tits M; Angenot L; Bailly C
The plant alkaloid usambarensine intercalates into DNA and induces apoptosis in human HL60 leukemia cells.
Anticancer research 1999;19(6B):5245-50.
-
1999: Bailly C; Lansiaux A; Dassonneville L; Demarquay D; Coulomb H; Huchet M; Lavergne O; Bigg D C
Homocamptothecin, an E-ring-modified camptothecin analogue, generates new topoisomerase I-mediated DNA breaks.
Biochemistry 1999;38(47):15556-63.
-
1999: Routier S; Vezin H; Lamour E; Bernier J L; Catteau J P; Bailly C
DNA cleavage by hydroxy-salicylidene-ethylendiamine-iron complexes.
Nucleic acids research 1999;27(21):4160-6.
-
1999: Qu X; Chaires J B; Ohkubo M; Yoshinari T; Nishimura S; Bailly C
A DNA binding indolocarbazole disaccharide derivative remains highly cytotoxic without inhibiting topoisomerase I.
Anti-cancer drug design 1999;14(5):433-42.
-
1999: Dassonneville L; Bailly C
Stimulation of topoisomerase II-mediated DNA cleavage by an indazole analogue of lucanthone.
Biochemical pharmacology 1999;58(8):1307-12.
-
1999: Bailly C; Crow S; Minnock A; Waring M J
Demethylation of thymine residues affects DNA cleavage by endonucleases but not sequence recognition by drugs.
Journal of molecular biology 1999;291(3):561-73.
-
1999: Catrycke M O; Houssin R; Hénichart J P; Pfeiffer B; Renard P; Dassonneville L; Bailly C
Synthesis and cytotoxicity of analogues of the antibiotic BE 10988 inhibitors of DNA topoisomerase II.
Bioorganic & medicinal chemistry letters 1999;9(14):2025-30.
-
1999: Bailly C; Qu X; Chaires J B; Colson P; Houssier C; Ohkubo M; Nishimura S; Yoshinari T
Substitution at the F-ring N-imide of the indolocarbazole antitumor drug NB-506 increases the cytotoxicity, DNA binding, and topoisomerase I inhibition activities.
Journal of medicinal chemistry 1999;42(15):2927-35.
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1999: Bailly C; Carrasco C; Hamy F; Vezin H; Prudhomme M; Saleem A; Rubin E
The camptothecin-resistant topoisomerase I mutant F361S is cross-resistant to antitumor rebeccamycin derivatives. A model for topoisomerase I inhibition by indolocarbazoles.
Biochemistry 1999;38(27):8605-11.
-
1999: Dassonneville L; Bonjean K; De Pauw-Gillet M C; Colson P; Houssier C; Quetin-Leclercq J; Angenot L; Bailly C
Stimulation of topoisomerase II-mediated DNA cleavage by three DNA-intercalating plant alkaloids: cryptolepine, matadine, and serpentine.
Biochemistry 1999;38(24):7719-26.
-
1999: Lesueur-Ginot L; Demarquay D; Kiss R; Kasprzyk P G; Dassonneville L; Bailly C; Camara J; Lavergne O; Bigg D C
Homocamptothecin, an E-ring modified camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and antitumor properties.
Cancer research 1999;59(12):2939-43.
-
1999: Bailly C; Dassonneville L; Colson P; Houssier C; Fukasawa K; Nishimura S; Yoshinari T
Intercalation into DNA is not required for inhibition of topoisomerase I by indolocarbazole antitumor agents.
Cancer research 1999;59(12):2853-60.
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1999: Moreau P; Anizon F; Sancelme M; Prudhomme M; Sevère D; Riou J F; Goossens J F; Hénichart J P; Bailly C; Labourier E; Tazzi J; Fabbro D; Meyer T; Aubertin A M
Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives.
Journal of medicinal chemistry 1999;42(10):1816-22.
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1999: Bailly C; Dassonneville L; Carrasco C; Lucas D; Kumar A; Boykin D W; Wilson W D
Relationships between topoisomerase II inhibition, sequence-specificity and DNA binding mode of dicationic diphenylfuran derivatives.
Anti-cancer drug design 1999;14(1):47-60.
-
1999: Moreau P; Anizon F; Sancelme M; Prudhomme M; Bailly C; Sevère D; Riou J F; Fabbro D; Meyer T; Aubertin A M
Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent.
Journal of medicinal chemistry 1999;42(4):584-92.
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1999: Bailly C; Qu X; Anizon F; Prudhomme M; Riou J F; Chaires J B
Enhanced binding to DNA and topoisomerase I inhibition by an analog of the antitumor antibiotic rebeccamycin containing an amino sugar residue.
Molecular pharmacology 1999;55(2):377-85.
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1999: Labourier E; Riou J F; Prudhomme M; Carrasco C; Bailly C; Tazi J
Poisoning of topoisomerase I by an antitumor indolocarbazole drug: stabilization of topoisomerase I-DNA covalent complexes and specific inhibition of the protein kinase activity.
Cancer research 1999;59(1):52-5.
-
1998: Sissi C; Bolgan L; Moro S; Zagotto G; Bailly C; Menta E; Capranico G; Palumbo M
DNA-binding preferences of bisantrene analogues: relevance to the sequence specificity of drug-mediated topoisomerase II poisoning.
Molecular pharmacology 1998;54(6):1036-45.
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1998: Anizon F; Moreau P; Sancelme M; Voldoire A; Prudhomme M; Ollier M; Sevère D; Riou J F; Bailly C; Fabbro D; Meyer T; Aubertin A M
Syntheses, biochemical and biological evaluation of staurosporine analogues from the microbial metabolite rebeccamycin.
Bioorganic & medicinal chemistry 1998;6(9):1597-604.
-
1998: Routier S; Bernier J L; Catteau J P; Riou J F; Bailly C
Synthesis, DNA binding, topoisomerase II inhibition and cytotoxicity of two guanidine-containing anthracene-9,10-diones.
Anti-cancer drug design 1998;13(5):407-15.
-
1998: Moreau P; Anizon F; Sancelme M; Prudhomme M; Bailly C; Carrasco C; Ollier M; Sevère D; Riou J F; Fabbro D; Meyer T; Aubertin A M
Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle.
Journal of medicinal chemistry 1998;41(10):1631-40.
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1998: Bonjean K; De Pauw-Gillet M C; Defresne M P; Colson P; Houssier C; Dassonneville L; Bailly C; Greimers R; Wright C; Quetin-Leclercq J; Tits M; Angenot L
The DNA intercalating alkaloid cryptolepine interferes with topoisomerase II and inhibits primarily DNA synthesis in B16 melanoma cells.
Biochemistry 1998;37(15):5136-46.
-
1998: Carrasco C; Waring M J; Bailly C
Substitution of 5-methylcytosines for cytosines enhances the stability of topoisomerase I-DNA complexes and modulates the sequence selectivity of camptothecin-induced DNA cleavage.
FEBS letters 1998;425(2):337-40.
-
1998: Bailly C; Waring M J
DNA recognition by quinoxaline antibiotics: use of base-modified DNA molecules to investigate determinants of sequence-specific binding of triostin A and TANDEM.
The Biochemical journal 1998;330 ( Pt 1)():81-7.
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1998: Bailly C; Colson P; Houssier C; Rodrigues-Pereira E; Prudhomme M; Waring M J
Recognition of specific sequences in DNA by a topoisomerase I inhibitor derived from the antitumor drug rebeccamycin.
Molecular pharmacology 1998;53(1):77-87.
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1998: Bailly C; Viossat B; Labouze X; Morgant G; Saturnino C; Lancelot J C; Robba M; Dung N H
Synthesis, Crystal Structure and Interaction With DNA of N,N'-(Butane-1,4-Diyl)Bis(Guanidinium) Tetrachloroplatinate (II).
Metal-based drugs 1998;5(5):279-85.
-
1997: Routier S; Bernier J L; Catteau J P; Colson P; Houssier C; Rivalle C; Bisagni E; Bailly C
Synthesis, DNA binding, and cleaving properties of an ellipticine-salen.copper conjugate.
Bioconjugate chemistry 1997;8(6):789-92.
-
1997: Dassonneville L; Hamy F; Colson P; Houssier C; Bailly C
Binding of Hoechst 33258 to the TAR RNA of HIV-1. Recognition of a pyrimidine bulge-dependent structure.
Nucleic acids research 1997;25(22):4487-92.
-
1997: Anizon F; Belin L; Moreau P; Sancelme M; Voldoire A; Prudhomme M; Ollier M; Sevère D; Riou J F; Bailly C; Fabbro D; Meyer T
Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.
Journal of medicinal chemistry 1997;40(21):3456-65.
-
1997: Waring M J; Bailly C
The influence of the exocyclic amino group characteristic of GC base pairs on molecular recognition of specific nucleotide sequences in DNA by berenil and DAPI.
Journal of molecular recognition : JMR 1997;10(3):121-7.
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1997: Henichart J P; Waring M J; Riou J F; Denny W A; Bailly C
Copper-dependent oxidative and topoisomerase II-mediated DNA cleavage by a netropsin/4'-(9-acridinylamino)methanesulfon-m-anisidide combilexin.
Molecular pharmacology 1997;51(3):448-61.
-
1996: Bailly C; Denny W A; Waring M J
Molecular origins of selectivity in the interaction of amsacrine-4-carboxamide with GC-rich sequences in DNA.
Anti-cancer drug design 1996;11(8):611-24.
-
1996: Bailly C; Payet D; Travers A A; Waring M J
PCR-based development of DNA substrates containing modified bases: an efficient system for investigating the role of the exocyclic groups in chemical and structural recognition by minor groove binding drugs and proteins.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):13623-8.
-
1996: Bailly C; Minnock A; Waring M J
A simple ligation assay to detect effects of drugs on the curvature/flexibility of DNA.
FEBS letters 1996;396(2-3):253-6.
-
1996: Bourdouxhe-Housiaux C; Colson P; Houssier C; Bailly C
Interaction of DNA-threading peptide-amsacrine conjugates with DNA and chromatin.
Anti-cancer drug design 1996;11(7):509-25.
-
1996: Routier S; Cotelle N; Catteau J P; Bernier J L; Waring M J; Riou J F; Bailly C
Salen-anthraquinone conjugates. Synthesis, DNA-binding and cleaving properties, effects on topoisomerases and cytotoxicity.
Bioorganic & medicinal chemistry 1996;4(8):1185-96.
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1996: Bailly C; Braña M; Waring M J
Sequence-selective intercalation of antitumour bis-naphthalimides into DNA. Evidence for an approach via the major groove.
European journal of biochemistry / FEBS 1996;240(1):195-208.
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1996: Marchand C; Bailly C; Nguyen C H; Bisagni E; Garestier T; Hélène C; Waring M J
Stabilization of triple helical DNA by a benzopyridoquinoxaline intercalator.
Biochemistry 1996;35(15):5022-32.
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1996: Bailly C; Colson P; Houssier C; Hamy F
The binding mode of drugs to the TAR RNA of HIV-1 studied by electric linear dichroism.
Nucleic acids research 1996;24(8):1460-4.
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1996: Bourdouxhe-Housiaux C; Colson P; Houssier C; Waring M J; Bailly C
Interaction of a DNA-threading netropsin-amsacrine combilexin with DNA and chromatin.
Biochemistry 1996;35(14):4251-64.
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1996: Bailly C; Routier S; Bernier J L; Waring M J
DNA recognition by two mitoxantrone analogues: influence of the hydroxyl groups.
FEBS letters 1996;379(3):269-72.
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1996: Colson P; Bailly C; Houssier C
Electric linear dichroism as a new tool to study sequence preference in drug binding to DNA.
Biophysical chemistry 1996;58(1-2):125-40.
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1996: Bailly C; Hamy F; Waring M J
Cooperativity in the binding of echinomycin to DNA fragments containing closely spaced CpG sites.
Biochemistry 1996;35(4):1150-61.
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1995: Colson P; Houssier C; Bailly C
Use of electric linear dichroism and competition experiments with intercalating drugs to investigate the mode of binding of Hoechst 33258, berenil and DAPI to GC sequences.
Journal of biomolecular structure & dynamics 1995;13(2):351-66.
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1995: Bailly C; Waring M J; Travers A A
Effects of base substitutions on the binding of a DNA-bending protein.
Journal of molecular biology 1995;253(1):1-7.
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1995: Bailly C; Kénani A; Waring M J
Analogue versus digital recognition of DNA by bleomycin: an effect of the carbohydrate moiety.
FEBS letters 1995;372(2-3):144-7.
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1995: Bailly C; Marchand C; Hung Nguyen C; Bisagni E; Garestier T; Hélène C; Waring M J
Localized chemical reactivity in double-stranded DNA associated with the intercalative binding of benzo[e]pyridoindole and benzo[g]pyridoindole triple-helix-stabilizing ligands.
European journal of biochemistry / FEBS 1995;232(1):66-76.
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1995: Bailly C; Møllegaard N E; Nielsen P E; Waring M J
The influence of the 2-amino group of guanine on DNA conformation. Uranyl and DNase I probing of inosine/diaminopurine substituted DNA.
The EMBO journal 1995;14(9):2121-31.
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1995: Bailly C; Waring M J
Transferring the purine 2-amino group from guanines to adenines in DNA changes the sequence-specific binding of antibiotics.
Nucleic acids research 1995;23(6):885-92.
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1995: Plouvier B; Houssin R; Helbecque N; Colson P; Houssier C; Hénichart J P; Bailly C
Influence of the methyl substituents of a thiazole-containing lexitropsin on the mode of binding to DNA.
Anti-cancer drug design 1995;10(2):155-66.
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1995: Bourdouxhe C; Colson P; Houssier C; Hénichart J P; Waring M J; Denny W A; Bailly C
Design of composite drug molecules: mutual effects on binding to DNA of an intercalator, amsacrine, and a minor groove binder, netropsin.
Anti-cancer drug design 1995;10(2):131-54.
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1995: Bailly C; Waring M J
Comparison of different footprinting methodologies for detecting binding sites for a small ligand on DNA.
Journal of biomolecular structure & dynamics 1995;12(4):869-98.
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1994: Ridge G S; Bailly C; Graves D E; Waring M J
Daunomycin modifies the sequence-selective recognition of DNA by actinomycin.
Nucleic acids research 1994;22(24):5241-6.
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1994: Bailly C; Michaux C; Colson P; Houssier C; Sun J S; Garestier T; Hélène C; Hénichart J P; Rivalle C; Bisagni E
Reaction of a biscationic distamycin-ellipticine hybrid ligand with DNA. Mode and sequence specificity of binding.
Biochemistry 1994;33(51):15348-64.
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1994: Waring M J; Bailly C
The purine 2-amino group as a critical recognition element for binding of small molecules to DNA.
Gene 1994;149(1):69-79.
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1994: Plouvier B; Houssin R; Hecquet B; Colson P; Houssier C; Waring M J; Hénichart J P; Bailly C
Antitumor combilexin. A thiazole-containing analogue of netropsin linked to an acridine chromophore.
Bioconjugate chemistry 1994;5(5):475-81.
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1994: Bailly C; Donkor I O; Gentle D; Thornalley M; Waring M J
Sequence-selective binding to DNA of cis- and trans- butamidine analogues of the anti-Pneumocystis carinii pneumonia drug pentamidine.
Molecular pharmacology 1994;46(2):313-22.
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1994: Bailly C; Graves D E; Ridge G; Waring M J
Use of a photoactive derivative of actinomycin to investigate shuffling between binding sites on DNA.
Biochemistry 1994;33(29):8736-45.
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1994: Rao K E; Gosselin G; Mrani D; Périgaud C; Imbach J L; Bailly C; Hénichart J P; Colson P; Houssier C; Lown J W
Psoralen--lexitropsin hybrids: DNA sequence selectivity of photoinduced cross-linking from MPE footprinting and exonuclease III stop assay, and mode of binding from electric linear dichroism.
Anti-cancer drug design 1994;9(3):221-37.
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1994: Waring M J; Bailly C
DNA recognition by intercalators and hybrid molecules.
Journal of molecular recognition : JMR 1994;7(2):109-22.
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1994: Bailly C; Gentle D; Hamy F; Purcell M; Waring M J
Localized chemical reactivity in DNA associated with the sequence-specific bisintercalation of echinomycin.
The Biochemical journal 1994;300 ( Pt 1)():165-73.
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1994: Flock S; Bailly F; Bailly C; Waring M J; Hénichart J P; Colson P; Houssier C
Interaction of two peptide-acridine conjugates containing the SPKK peptide motif with DNA and chromatin.
Journal of biomolecular structure & dynamics 1994;11(4):881-900.
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1993: Bailly F; Bailly C; Colson P; Houssier C; Hénichart J P
A tandem repeat of the SPKK peptide motif induces psi-type DNA structures at alternating AT sequences.
FEBS letters 1993;324(2):181-4.
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1993: Bailly C; Waring M J
Preferential intercalation at AT sequences in DNA by lucanthone, hycanthone, and indazole analogs. A footprinting study.
Biochemistry 1993;32(23):5985-93.
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1993: Bailly C; Leclere V; Pommery N; Colson P; Houssier C; Rivalle C; Bisagni E; Hénichart J P
Binding to DNA, cellular uptake and biological activity of a distamycin-ellipticine hybrid molecule.
Anti-cancer drug design 1993;8(2):145-64.
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1993: Bailly C; Cuthbert A W; Gentle D; Knowles M R; Waring M J
Sequence-selective binding of amiloride to DNA.
Biochemistry 1993;32(10):2514-24.
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1992: Bailly C; Hénichart J P; Colson P; Houssier C
Drug-DNA sequence-dependent interactions analysed by electric linear dichroism.
Journal of molecular recognition : JMR 1992;5(4):155-71.
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1992: Marchand C; Bailly C; McLean M J; Moroney S E; Waring M J
The 2-amino group of guanine is absolutely required for specific binding of the anti-cancer antibiotic echinomycin to DNA.
Nucleic acids research 1992;20(21):5601-6.
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1992: Bailly C; Colson P; Houssier C; Houssin R; Mrani D; Gosselin G; Imbach J L; Waring M J; Lown J W; Hénichart J P
Binding properties and DNA sequence-specific recognition of two bithiazole-linked netropsin hybrid molecules.
Biochemistry 1992;31(35):8349-62.
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1992: Bailly C; O'Huigin C; Houssin R; Colson P; Houssier C; Rivalle C; Bisagni E; Henichart J P; Waring M J
DNA-binding properties of a distamycin-ellipticine hybrid molecule.
Molecular pharmacology 1992;41(5):845-55.
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1992: Bailly C; Denny W A; Mellor L E; Wakelin L P; Waring M J
Sequence specificity of the binding of 9-aminoacridine- and amsacrine-4-carboxamides to DNA studied by DNase I footprinting.
Biochemistry 1992;31(13):3514-24.
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1992: Bailly F; Bailly C; Waring M J; Hénichart J P
Selective binding to AT sequences in DNA by an acridine-linked peptide containing the SPKK motif.
Biochemical and biophysical research communications 1992;184(2):930-7.
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1992: Bailly F; Bailly C; Helbecque N; Pommery N; Colson P; Houssier C; Hénichart J P
Relationship between DNA-binding and biological activity of anilinoacridine derivatives containing the nucleic acid-binding unit SPKK.
Anti-cancer drug design 1992;7(1):83-100.
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1991: Plouvier B; Bailly C; Houssin R; Rao K E; Lown W J; Hénichart J P; Waring M J
DNA-sequence specific recognition by a thiazole analogue of netropsin: a comparative footprinting study.
Nucleic acids research 1991;19(21):5821-9.
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1990: Bailly C; OhUigin C; Rivalle C; Bisagni E; Hénichart J P; Waring M J
Sequence-selective binding of an ellipticine derivative to DNA.
Nucleic acids research 1990;18(21):6283-91.
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1990: Bailly C; Helbecque N; Hénichart J P; Colson P; Houssier C; Rao K E; Shea R G; Lown J W
Molecular recognition between oligopeptides and nucleic acids. DNA sequence specificity and binding properties of an acridine-linked netropsin hybrid ligand.
Journal of molecular recognition : JMR 1990;3(1):26-35.
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1990: Bailly C; Beauvillain J C; Bernier J L; Hénichart J P
Plasma membrane perturbations of KB3 cells induced by the bleomycin-iron complex.
Cancer research 1990;50(2):385-92.
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1989: Bailly C; Pommery N; Houssin R; Henichart J P
Design, synthesis, DNA binding, and biological activity of a series of DNA minor-groove-binding intercalating drugs.
Journal of pharmaceutical sciences 1989;78(11):910-7.
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1989: Morier-Teissier E; Bailly C; Bernier J L; Houssin R; Helbecque N; Catteau J P; Colson P; Houssier C; Hénichart J P
Synthesis, biological activity and DNA interaction of anilinoacridine and bithiazole peptide derivatives related to the anti-tumor drugs m-AMSA and bleomycin.
Anti-cancer drug design 1989;4(1):37-52.
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1989: Bailly C; Catteau J P; Hénichart J P; Reszka K; Shea R G; Krowicki K; Lown J W
Subcellular distribution of a nitroxide spin-labeled netropsin in living KB cells. Electron paramagnetic resonance and sequence specificity studies.
Biochemical pharmacology 1989;38(10):1625-30.
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1989: Bailly C; Houssin R; Bernier J L; Henichart J P
[Interaction of bleomycin with the plasmid membrane: changes in the fluidity and peroxidation of lipids]
Bulletin du cancer 1989;76(8):835-7.
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1988: Bailly C; Kenani A; Helbecque N; Bernier J L; Houssin R; Hénichart J P
DNA-binding and DNA-cleaving properties of a synthetic model AGAGLU related to the antitumour drugs AMSA and bleomycin.
Biochemical and biophysical research communications 1988;152(2):695-702.
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1988: Bailly C; Pommery N; Henichart J P
DNA-synthesis and tumor growth inhibitions by AGGA, a bleomycin-amsacrine hybrid derivative.
Cancer letters 1988;38(3):321-8.
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