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Christian Bailly

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Caroline Ballot; Pierre Formstecher; Manel Jendoubi; Aurélie Jonneaux; jerome kluza; William Laine; Christian Bailly; Philippe MARCHETTI
Regulation by survivin of cancer cell death induced by F14512, a polyamine-containing inhibitor of DNA topoisomerase II.
Youssef Hajbi; Cléopatra Neagoie; Bérenger Biannic; Aurélie Chilloux; Emeline Vedrenne; Brigitte Baldeyrou; Christian Bailly; Jean-Yves Mérour; Sorin Rosca; Sylvain Routier; Amélie Lansiaux
Synthesis and biological activities of new furo[3,4-b]carbazoles: potential topoisomerase II inhibitors.
Caroline Ballot; jerome kluza; Steve Lancel; Alain Martoriati; Sidi Mohamed Hassoun; Laurent Mortier; Jean-Claude Vienne; Gilbert Briand; Pierre Formstecher; Christian Bailly; Remi Nevière; Philippe MARCHETTI
Inhibition of mitochondrial respiration mediates apoptosis induced by the anti-tumoral alkaloid lamellarin D.

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All Publications

2012: Caroline Ballot; Pierre Formstecher; Manel Jendoubi; Aurélie Jonneaux; jerome kluza; William Laine; Christian Bailly; Philippe MARCHETTI
Regulation by survivin of cancer cell death induced by F14512, a polyamine-containing inhibitor of DNA topoisomerase II.
Apoptosis : an international journal on programmed cell death 2012;17(4):364-76.
2010: Youssef Hajbi; Cléopatra Neagoie; Bérenger Biannic; Aurélie Chilloux; Emeline Vedrenne; Brigitte Baldeyrou; Christian Bailly; Jean-Yves Mérour; Sorin Rosca; Sylvain Routier; Amélie Lansiaux
Synthesis and biological activities of new furo[3,4-b]carbazoles: potential topoisomerase II inhibitors.
European journal of medicinal chemistry 2010;45(11):5428-37.
2010: Caroline Ballot; jerome kluza; Steve Lancel; Alain Martoriati; Sidi Mohamed Hassoun; Laurent Mortier; Jean-Claude Vienne; Gilbert Briand; Pierre Formstecher; Christian Bailly; Remi Nevière; Philippe MARCHETTI
Inhibition of mitochondrial respiration mediates apoptosis induced by the anti-tumoral alkaloid lamellarin D.
Apoptosis : an international journal on programmed cell death 2010;15(7):769-81.
2009: Sabine Depauw; Thomas Gaslonde; Stéphane Léonce; Laurence Kraus-Berthier; William Laine; Gaëlle Lenglet; Angèle Chiaroni; Bruno Pfeiffer; Christian Bailly; Sylvie Michel; François Tillequin; Alain Pierré; Marie-Hélène David-Cordonnier
Influence of the stereoisomeric position of the reactive acetate groups of the benzo[b]acronycine derivative S23906-1 on its DNA alkylation, helix-opening, cytotoxic, and antitumor activities.
Molecular pharmacology 2009;76(6):1172-85.
2009: Pierre Vekhoff; Ludovic Halby; Kahina Oussedik; Sabrina Dallavalle; Lucio Merlini; Christine Mahieu; Amélie Lansiaux; Christian Bailly; Alexandre Boutorine; Claudio Pisano; Giuseppe Giannini; Domenico Alloatti; Paola B Arimondo
Optimized synthesis and enhanced efficacy of novel triplex-forming camptothecin derivatives based on gimatecan.
Bioconjugate chemistry 2009;20(4):666-72.
2008: Aurélie Bourderioux; Valérie Bénéteau; Jean-Yves Mérour; Brigitte Baldeyrou; Caroline Ballot; Amélie Lansiaux; Christian Bailly; Rémy Le Guével; Christiane Guillouzo; Sylvain Routier
Synthesis and biological evaluation of novel oxophenylarcyriaflavins as potential anticancer agents.
Organic & biomolecular chemistry 2008;6(12):2108-17.
2008: Ulrich Jacquemard; Nathalie Dias; Amélie Lansiaux; Christian Bailly; Cédric Logé; Jean-Michel Robert; Olivier Lozach; Laurent Meijer; Jean-Yves Mérour; Sylvain Routier
Synthesis of 3,5-bis(2-indolyl)pyridine and 3-[(2-indolyl)-5-phenyl]pyridine derivatives as CDK inhibitors and cytotoxic agents.
Bioorganic & medicinal chemistry 2008;16(9):4932-53.
2007: Manoj Munde; Mohamed A Ismail; Reem K Arafa; Paul Peixoto; Catharine J Collar; Yang Liu; Laixing Hu; Marie-Hélène David-Cordonnier; Amélie Lansiaux; Christian Bailly; David W Boykin; David W. Wilson
Design of DNA minor groove binding diamidines that recognize GC base pair sequences: a dimeric-hinge interaction motif.
Journal of the American Chemical Society 2007;129(44):13732-43.
2007: Bernadette Hugon; Fabrice Anizon; Christian Bailly; Roy M Golsteyn; Alain Pierré; Stéphane Léonce; John Hickman; Bruno Pfeiffer; Michelle Prudhomme
Synthesis and biological activities of isogranulatimide analogues.
Bioorganic & medicinal chemistry 2007;15(17):5965-80.
2007: Amélie Lansiaux; Stéphane Léonce; Laurence Kraus-Berthier; Christine Bal-Mahieu; Romain Mazinghien; Sébastien Didier; Marie-Hélène David-Cordonnier; Patrick Hautefaye; Gilbert Lavielle; Christian Bailly; John A Hickman; Alain Pierré
Novel stable camptothecin derivatives replacing the E-ring lactone by a ketone function are potent inhibitors of topoisomerase I and promising antitumor drugs.
Molecular pharmacology 2007;72(2):311-9.
2007: Ana Negri; Esther Marco; Verónica García-Hernández; Alberto Domingo; Antonio Luis Llamas-Saiz; Silvia Porto-Sandá; Ricardo Riguera; William Laine; Marie-Hélène David-Cordonnier; Christian Bailly; Luis F García-Fernández; Juan J Vaquero; Federico Gago
Antitumor activity, X-ray crystal structure, and DNA binding properties of thiocoraline A, a natural bisintercalating thiodepsipeptide.
Journal of medicinal chemistry 2007;50(14):3322-33.
2007: Farial A Tanious; William Laine; Paul Peixoto; Christian Bailly; Kristie D. Goodwin; Mark A Lewis; Eric C Long; Millie M Georgiadis; Richard R Tidwell; David W. Wilson
Unusually strong binding to the DNA minor groove by a highly twisted benzimidazole diphenylether: induced fit and bound water.
Biochemistry 2007;46(23):6944-56.
2007: Manoj Munde; Michael Lee; Stephen Neidle; Reem K Arafa; David W Boykin; Yang Liu; Christian Bailly; David W. Wilson
Induced fit conformational changes of a "reversed amidine" heterocycle: optimized interactions in a DNA minor groove complex.
Journal of the American Chemical Society 2007;129(17):5688-98.
2006: Jean-François Goossens; Christine Mahieu; Nathalie Dias; Christian Bailly; Paola Principe; Jean-Paul Bonte; Amélie Lansiaux; Claude Vaccher; Catherine Foulon
Chiral capillary electrophoretic determination of the enantiomeric purity of homocamptothecin derivatives, promising antitumor topoisomerase I inhibitors, using highly sulfated CDs and fluorescence detection.
Electrophoresis 2006;27(23):4717-29.
2006: Esther Marco; Marie-Hélène David-Cordonnier; Christian Bailly; Carmen Cuevas; Federico Gago
Further insight into the DNA recognition mechanism of trabectedin from the differential affinity of its demethylated analogue ecteinascidin ET729 for the triplet DNA binding site CGA.
Journal of medicinal chemistry 2006;49(23):6925-9.
2006: Marie-Hélène David-Cordonnier; Maxwell A Casely-Hayford; Mostafa Kouach; Gilbert Briand; Laurence H Patterson; Christian Bailly; Mark Searcey
Stereoselectivity, sequence specificity and mechanism of action of the azinomycin epoxide.
Chembiochem : a European journal of chemical biology 2006;7(11):1658-61.
2006: jerome kluza; Miguel-Angel Gallego; Anne Loyens; Jean-Claude Beauvillain; José-Maria Fernandez Sousa-Faro; Carmen Cuevas; Philippe MARCHETTI; Christian Bailly
Cancer cell mitochondria are direct proapoptotic targets for the marine antitumor drug lamellarin D.
Cancer research 2006;66(6):3177-87.
2006: jerome kluza; Romain Mazinghien; Helen Irwin; John A Hartley; Christian Bailly
Relationships between DNA strand breakage and apoptotic progression upon treatment of HL-60 leukemia cells with tafluposide or etoposide.
Anti-cancer drugs 2006;17(2):155-64.
2006: Sylvain Routier; Jean-Yves Mérour; Nathalie Dias; Amélie Lansiaux; Christian Bailly; Olivier Lozach; Laurent Meijer
Synthesis and biological evaluation of novel phenylcarbazoles as potential anticancer agents.
Journal of medicinal chemistry 2006;49(2):789-99.
2006: Paola B Arimondo; Craig J Thomas; Kahina Oussedik; Brigitte Baldeyrou; Christine Mahieu; Ludovic Halby; Dominique Guianvarc'h; Amélie Lansiaux; Sidney Hecht; Christian Bailly; Carine Giovannangeli
Exploring the cellular activity of camptothecin-triple-helix-forming oligonucleotide conjugates.
Molecular and cellular biology 2006;26(1):324-33.
2005: Nathalie Dias; Ulrich Jacquemard; Brigitte Baldeyrou; Amélie Lansiaux; Jean-François Goossens; Christian Bailly; Sylvain Routier; Jean-Yves Mérour
Synthesis of 2,6-diphenylpyrazine derivatives and their DNA binding and cytotoxic properties.
European journal of medicinal chemistry 2005;40(12):1206-13.
2005: jerome kluza; Romain Mazinghien; Klara Degardin; Amélie Lansiaux; Christian Bailly
Induction of apoptosis by the plant alkaloid sampangine in human HL-60 leukemia cells is mediated by reactive oxygen species.
European journal of pharmacology 2005;525(1-3):32-40.
2005: Marie-Hélène David-Cordonnier; Consuelo Gajate; Osvaldo Olmea; William Laine; Janis de la Iglesia-Vicente; Carlos Perez; Carmen Cuevas; Gabriel Otero; Ignacio Manzanares; Christian Bailly; Faustino Mollinedo
DNA and non-DNA targets in the mechanism of action of the antitumor drug trabectedin.
Chemistry & biology 2005;12(11):1201-10.
2005: Ulrich Jacquemard; Sylvain Routier; Nathalie Dias; Amélie Lansiaux; Jean-François Goossens; Christian Bailly; Jean-Yves Mérour
Synthesis of 2,5- and 3,5-diphenylpyridine derivatives for DNA recognition and cytotoxicity.
European journal of medicinal chemistry 2005;40(11):1087-95.
2005: Huong Doan Thi Mai; Thomas Gaslonde; Sylvie Michel; Michel Koch; François Tillequin; Christian Bailly; Marie-Hélène David-Cordonnier; Bruno Pfeiffer; Stéphane Léonce; Alain Pierré
Design, synthesis, and cytotoxic activity of Michael acceptors and enol esters in the benzo[b]acronycine series.
Chemical & pharmaceutical bulletin 2005;53(8):919-22.
2005: Nathalie Dias; Jean-François Goossens; Brigitte Baldeyrou; Amélie Lansiaux; Pierre Colson; Alberto Di Salvo; Jeanne Bernal; Agnes Turnbull; David J Mincher; Christian Bailly
Oxoazabenzo[de]anthracenes conjugated to amino acids: synthesis and evaluation as DNA-binding antitumor agents.
Bioconjugate chemistry 2005;16(4):949-58.
2005: Nathalie Dias; Christian Bailly
Drugs targeting mitochondrial functions to control tumor cell growth.
Biochemical pharmacology 2005;70(1):1-12.
2005: Esther Marco; William Laine; Christelle Tardy; Amélie Lansiaux; Masatomo Iwao; Fumito Ishibashi; Christian Bailly; Federico Gago
Molecular determinants of topoisomerase I poisoning by lamellarins: comparison with camptothecin and structure-activity relationships.
Journal of medicinal chemistry 2005;48(11):3796-807.
2005: Marie Vanhuyse; jerome kluza; Christelle Tardy; Gabriel Otero; Carmen Cuevas; Christian Bailly; Amélie Lansiaux
Lamellarin D: a novel pro-apoptotic agent from marine origin insensitive to P-glycoprotein-mediated drug efflux.
Cancer letters 2005;221(2):165-75.
2005: Jamal Tazi; Nadia Bakkour; Johann Soret; Latifa Zekri; Banasri Hazra; William Laine; Brigitte Baldeyrou; Amélie Lansiaux; Christian Bailly
Selective inhibition of topoisomerase I and various steps of spliceosome assembly by diospyrin derivatives.
Molecular pharmacology 2005;67(4):1186-94.
2005: Paola B Arimondo; Gary S Laco; Craig J Thomas; Ludovic Halby; Didier Pez; Philippe Schmitt; Alexandre S Boutorine; Thérèse Garestier; Yves Pommier; Sidney Hecht; Jian-Sheng Sun; Christian Bailly
Activation of camptothecin derivatives by conjugation to triple helix-forming oligonucleotides.
Biochemistry 2005;44(11):4171-80.
2005: Sylvain Routier; Paul Peixoto; Jean-Yves Mérour; Gérard Coudert; Nathalie Dias; Christian Bailly; Alain Pierré; Stéphane Léonce; Daniel-Henri Caignard
Synthesis and biological evaluation of novel naphthocarbazoles as potential anticancer agents.
Journal of medicinal chemistry 2005;48(5):1401-13.
2005: Christian Bailly; Reem K Arafa; Farial A Tanious; William Laine; Christelle Tardy; Amélie Lansiaux; Pierre Colson; David W Boykin; David W. Wilson
Molecular determinants for DNA minor groove recognition: design of a bis-guanidinium derivative of ethidium that is highly selective for AT-rich DNA sequences.
Biochemistry 2005;44(6):1941-52.
2005: Marie-Hélène David-Cordonnier; William Laine; Amélie Lansiaux; Frédéric Rosu; Pierre Colson; Edwin De Pauw; Sylvie Michel; François Tillequin; Michel Koch; John A Hickman; Alain Pierré; Christian Bailly
Covalent binding of antitumor benzoacronycines to double-stranded DNA induces helix opening and the formation of single-stranded DNA: unique consequences of a novel DNA-bonding mechanism.
Molecular cancer therapeutics 2005;4(1):71-80.
2005: Christian Bailly; jerome kluza; Christopher Martin; Thomas Ellis; Michael J Waring
DNase I footprinting of small molecule binding sites on DNA.
Methods in molecular biology (Clifton, N.J.) 2005;288():319-42.
2004: Nathalie Dias; Ulrich Jacquemard; Brigitte Baldeyrou; Christelle Tardy; Amélie Lansiaux; Pierre Colson; Farial A Tanious; David W. Wilson; Sylvain Routier; Jean-Yves Mérour; Christian Bailly
Targeting DNA with novel diphenylcarbazoles.
Biochemistry 2004;43(48):15169-78.
2004: Christine Bal; Brigitte Baldeyrou; Florence Moz; Amélie Lansiaux; Pierre Colson; Laurence Kraus-Berthier; Stéphane Léonce; Alain Pierré; Marie-Françoise Boussard; Anne Rousseau; Michel Wierzbicki; Christian Bailly
Novel antitumor indenoindole derivatives targeting DNA and topoisomerase II.
Biochemical pharmacology 2004;68(10):1911-22.
2004: Sirish Mallena; Michael P H Lee; Christian Bailly; Stephen Neidle; Arvind Kumar; David W Boykin; David W. Wilson
Thiophene-based diamidine forms a "super" at binding minor groove agent.
Journal of the American Chemical Society 2004;126(42):13659-69.
2004: jerome kluza; Philippe MARCHETTI; Miguel-Angel Gallego; Steve Lancel; Charles Fournier; Anne Loyens; Jean-Claude Beauvillain; Christian Bailly
Mitochondrial proliferation during apoptosis induced by anticancer agents: effects of doxorubicin and mitoxantrone on cancer and cardiac cells.
Oncogene 2004;23(42):7018-30.
2004: Soizic Prado; Sylvie Michel; François Tillequin; Michel Koch; Bruno Pfeiffer; Alain Pierré; Stéphane Léonce; Pierre Colson; Brigitte Baldeyrou; Amélie Lansiaux; Christian Bailly
Synthesis and cytotoxic activity of benzo[c][1,7] and [1,8]phenanthrolines analogues of nitidine and fagaronine.
Bioorganic & medicinal chemistry 2004;12(14):3943-53.
2004: Sarah Catoen-Chackal; Michaël Facompré; Raymond Houssin; Nicole Pommery; Jean-François Goossens; Pierre Colson; Christian Bailly; Jean-Pierre Hénichart
DNA binding to guide the development of tetrahydroindeno[1,2-b]pyrido[4,3,2-de]quinoline derivatives as cytotoxic agents.
Journal of medicinal chemistry 2004;47(14):3665-73.
2004: Ulrich Jacquemard; Sylvain Routier; Arnaud Tatibouët; jerome kluza; William Laine; Christine Bal; Christian Bailly; Jean-Yves Mérour
Synthesis of diphenylcarbazoles as cytotoxic DNA binding agents.
Organic & biomolecular chemistry 2004;2(10):1476-83.
2004: Aline Voldoire; Pascale Moreau; Martine Sancelme; Mária Matulová; Stéphane Léonce; Alain Pierré; John Hickman; Bruno Pfeiffer; Pierre Renard; Nathalie Dias; Christian Bailly; Michelle Prudhomme
Analogues of antifungal tjipanazoles from rebeccamycin.
Bioorganic & medicinal chemistry 2004;12(8):1955-62.
2004: Christelle Tardy; Michaël Facompré; William Laine; Brigitte Baldeyrou; Dolores García-Gravalos; Andrés Francesch; Cristina Mateo; Alfredo Pastor; José A Jiménez; Ignacio Manzanares; Carmen Cuevas; Christian Bailly
Topoisomerase I-mediated DNA cleavage as a guide to the development of antitumor agents derived from the marine alkaloid lamellarin D: triester derivatives incorporating amino acid residues.
Bioorganic & medicinal chemistry 2004;12(7):1697-712.
2004: Géraldine Verquin; Gaëlle Fontaine; Marc Bria; Elena Zhilinskaya; Edmond Abi-Aad; Antoine Aboukaïs; Brigitte Baldeyrou; Christian Bailly; Jean-Luc Bernier
DNA modification by oxovanadium(IV) complexes of salen derivatives.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(3):345-53.
2004: Marie-Hélène David-Cordonnier; William Laine; Thomas Gaslonde; Sylvie Michel; François Tillequin; Michel Koch; Stéphane Léonce; Alain Pierré; Christian Bailly
Design of novel antitumor DNA alkylating agents: the benzacronycine series.
Current medicinal chemistry. Anti-cancer agents 2004;4(2):83-92.
2004: Stéphanie Blanchard; Ivan Rodriguez; Christelle Tardy; Brigitte Baldeyrou; Christian Bailly; Pierre Colson; Claude Houssier; Stéphane Léonce; Laurence Kraus-Berthier; Bruno Pfeiffer; Pierre Renard; Alain Pierré; Paul Caubère; Gérald Guillaumet
Synthesis of mono- and bisdihydrodipyridopyrazines and assessment of their DNA binding and cytotoxic properties.
Journal of medicinal chemistry 2004;47(4):978-87.
2004: Binh Nguyen; Donald Hamelberg; Christian Bailly; Pierre Colson; Jaroslav Stanek; Reto Brun; Stephen Neidle; David W. Wilson
Characterization of a novel DNA minor-groove complex.
Biophysical journal 2004;86(2):1028-41.
2004: Natacha Malecki; Pascal Carato; Benoît Rigo; Jean-François Goossens; Raymond Houssin; Christian Bailly; Jean-Pierre Hénichart
Synthesis of condensed quinolines and quinazolines as DNA ligands.
Bioorganic & medicinal chemistry 2004;12(3):641-7.
2004: Farial A Tanious; Donald Hamelberg; Christian Bailly; Agnieska Czarny; David W Boykin; David W. Wilson
DNA sequence dependent monomer-dimer binding modulation of asymmetric benzimidazole derivatives.
Journal of the American Chemical Society 2004;126(1):143-53.
2004: Marie-Hélène David-Cordonnier; William Laine; Mostafa Kouach; Gilbert Briand; Hervé Vezin; Thomas Gaslonde; Sylvie Michel; Huong Doan Thi Mai; François Tillequin; Michel Koch; Stéphane Léonce; Alain Pierré; Christian Bailly
A transesterification reaction is implicated in the covalent binding of benzo[b]acronycine anticancer agents with DNA and glutathion.
Bioorganic & medicinal chemistry 2004;12(1):23-9.
2004: Pauline Huyghe; Laurent Dassonneville; Pierre Fenaux; Christian Bailly
Hydroxyurea-induced apoptosis in an EBV-immortalized lymphoblastoid cell line.
Oncology research 2004;14(4-5):235-45.
2004: Stéphanie Solier; Amélie Lansiaux; Emmanuelle Logette; Jane Wu; Johann Soret; Jamal Tazi; Christian Bailly; Lydie Desoche; Eric Solary; Laurent Corcos
Topoisomerase I and II inhibitors control caspase-2 pre-messenger RNA splicing in human cells.
Molecular cancer research : MCR 2004;2(1):53-61.
2003: Christian Bailly; Christine Bal; pascale barbier; Sébastien Combes; Jean-Pierre Finet; Marie-Paule Hildebrand; Vincent Peyrot; Nicole Wattez
Synthesis and biological evaluation of 4-arylcoumarin analogues of combretastatins.
Journal of medicinal chemistry 2003;46(25):5437-44.
2003: jerome kluza; Alice M Clark; Christian Bailly
Apoptosis induced by the alkaloid sampangine in HL-60 leukemia cells: correlation between the effects on the cell cycle progression and changes of mitochondrial potential.
Annals of the New York Academy of Sciences 2003;1010():331-4.
2003: jerome kluza; Brigitte Baldeyrou; Pierre Colson; Philippe Rasoanaivo; Lengo Mambu; François Frappier; Christian Bailly
Cytotoxicity and DNA binding properties of the plant alkaloid burasaine.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2003;20(4-5):383-91.
2003: Farial A Tanious; David W. Wilson; Lei Wang; Arvind Kumar; David W Boykin; Carine Marty; Brigitte Baldeyrou; Christian Bailly
Cooperative dimerization of a heterocyclic diamidine determines sequence-specific DNA recognition.
Biochemistry 2003;42(46):13576-86.
2003: Pascale Moreau; Nathalie Gaillard; Christelle Marminon; Fabrice Anizon; Nathalie Dias; Brigitte Baldeyrou; Christian Bailly; Alain Pierré; John Hickman; Bruno Pfeiffer; Pierre Renard; Michelle Prudhomme
Semi-synthesis, topoisomerase I and kinases inhibitory properties, and antiproliferative activities of new rebeccamycin derivatives.
Bioorganic & medicinal chemistry 2003;11(23):4871-9.
2003: Michaël Facompré; Christelle Tardy; Christine Bal-Mahieu; Pierre Colson; Carlos Perez; Ignacio Manzanares; Carmen Cuevas; Christian Bailly
Lamellarin D: a novel potent inhibitor of topoisomerase I.
Cancer research 2003;63(21):7392-9.
2003: Carolina Carrasco; Alexandra Joubert; Christelle Tardy; Nicolas Maestre; Mónica Cacho; Miguel F Braña; Christian Bailly
DNA sequence recognition by bispyrazinonaphthalimides antitumor agents.
Biochemistry 2003;42(40):11751-61.
2003: Patrick Hautefaye; Bernard Cimetière; Alain Pierré; Stéphane Léonce; John Hickman; William Laine; Christian Bailly; Gilbert Lavielle
Synthesis and pharmacological evaluation of novel non-lactone analogues of camptothecin.
Bioorganic & medicinal chemistry letters 2003;13(16):2731-5.
2003: Fabrice Anizon; Pascale Moreau; Martine Sancelme; William Laine; Christian Bailly; Michelle Prudhomme
Rebeccamycin analogues bearing amine substituents or other groups on the sugar moiety.
Bioorganic & medicinal chemistry 2003;11(17):3709-22.
2003: Paola B Arimondo; Stéphane Angenault; Ludovic Halby; Alexandre S Boutorine; Frederic Schmidt; Claude Monneret; Thérèse Garestier; Jian-Sheng Sun; Christian Bailly; Claude Hélène
Spatial organization of topoisomerase I-mediated DNA cleavage induced by camptothecin-oligonucleotide conjugates.
Nucleic acids research 2003;31(14):4031-40.
2003: Huong Doan Thi Mai; Thomas Gaslonde; Sylvie Michel; François Tillequin; Michel Koch; Jean-Bernard Bongui; Abdelhakim Elomri; Elisabeth Seguin; Bruno Pfeiffer; Pierre Renard; Marie-Hélène David-Cordonnier; William Laine; Christian Bailly; Laurence Kraus-Berthier; Stéphane Léonce; John A Hickman; Alain Pierré
Structure-activity relationships and mechanism of action of antitumor benzo[b]pyrano[3,2-h]acridin-7-one acronycine analogues.
Journal of medicinal chemistry 2003;46(14):3072-82.
2003: Marie-Hélène David-Cordonnier; William Laine; Alexandra Joubert; Christelle Tardy; Jean-François Goossens; Mostafa Kouach; Gilbert Briand; Huong Doan Thi Mai; Sylvie Michel; François Tillequin; Michel Koch; stephane leonce; Alain Pierre; Christian Bailly
Covalent binding to glutathione of the DNA-alkylating antitumor agent, S23906-1.
European journal of biochemistry / FEBS 2003;270(13):2848-59.
2003: Murielle Mimeault; Nicole Pommery; Nicole Wattez; Christian Bailly; Jean-Pierre Hénichart
Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production.
The Prostate 2003;56(1):1-12.
2003: Alexandra Joubert; Xiao-Wen Sun; Eric Johansson; Christian Bailly; John Mann; Stephen Neidle
Sequence-selective targeting of long stretches of the DNA minor groove by a novel dimeric bis-benzimidazole.
Biochemistry 2003;42(20):5984-92.
2003: Michaël Facompré; Carolina Carrasco; Hervé Vezin; John D Chisholm; Joshua C Yoburn; David L Van Vranken; Christian Bailly
Indolocarbazole glycosides in inactive conformations.
Chembiochem : a European journal of chemical biology 2003;4(5):386-95.
2003: Christian Bailly; Carolina Carrasco; Alexandra Joubert; Christine Bal; Nicole Wattez; Marie-Paule Hildebrand; Amélie Lansiaux; Pierre Colson; Claude Houssier; Mónica Cacho; Ana Ramos; Miguel F Braña
Chromophore-modified bisnaphthalimides: DNA recognition, topoisomerase inhibition, and cytotoxic properties of two mono- and bisfuronaphthalimides.
Biochemistry 2003;42(14):4136-50.
2003: Aurore Perzyna; Raymond Houssin; Jean-François Goossens; Nicole Pommery; Carine Marty; Michaël Facompré; Pierre Colson; Claude Houssier; Christian Bailly; Jean-Pierre Hénichart
Indolizino[1,2-b]quinolines derived from A-D rings of camptothecin: synthesis and DNA interaction.
Journal of enzyme inhibition and medicinal chemistry 2003;18(2):101-9.
2003: Franck Charmantray; Martine Demeunynck; Danièle Carrez; Alain Croisy; Amélie Lansiaux; Christian Bailly; Pierre Colson
4-Hydroxymethyl-3-aminoacridine derivatives as a new family of anticancer agents.
Journal of medicinal chemistry 2003;46(6):967-77.
2003: Sarah Chackal; Michaël Facompré; Raymond Houssin; Jean-François Goossens; Nicole Pommery; Jean-Pierre Hénichart; Christian Bailly
Highly cytotoxic benzo[c]pyrido[2,3,4-kl]acridines.
Bioorganic & medicinal chemistry letters 2003;13(5):943-6.
2003: Christian Bailly; Gianni Chessari; Carolina Carrasco; Alexandra Joubert; John Mann; David W. Wilson; Stephen Neidle
Sequence-specific minor groove binding by bis-benzimidazoles: water molecules in ligand recognition.
Nucleic acids research 2003;31(5):1514-24.
2003: Miguel F Braña; Mónica Cacho; Ana Ramos; M Teresa Domínguez; José M Pozuelo; Cristina Abradelo; María Fernanda Rey-Stolle; Mercedes Yuste; Carolina Carrasco; Christian Bailly
Synthesis, biological evaluation and DNA binding properties of novel mono and bisnaphthalimides.
Organic & biomolecular chemistry 2003;1(4):648-54.
2003: Christelle Marminon; Alain Pierré; Bruno Pfeiffer; Valérie Pérez; Stéphane Léonce; Alexandra Joubert; Christian Bailly; Pierre Renard; John Hickman; Michelle Prudhomme
Syntheses and antiproliferative activities of 7-azarebeccamycin analogues bearing one 7-azaindole moiety.
Journal of medicinal chemistry 2003;46(4):609-22.
2003: Christian Bailly; Valérie Guerniou; Eric Lamour; Jean-Luc Bernier; Françoise Villain; Hervé Vezin
Site-specific cleavage of the HIV-1 TAR RNA by a hydroxysalen-copper(III) complex.
Chembiochem : a European journal of chemical biology 2003;4(1):112-4.
2003: Carolina Carrasco; Philippe Helissey; Michelyne Haroun; Brigitte Baldeyrou; Amélie Lansiaux; Pierre Colson; Claude Houssier; Sylviane Giorgi-Renault; Christian Bailly
Design of a composite ethidium-netropsin-anilinoacridine molecule for DNA recognition.
Chembiochem : a European journal of chemical biology 2003;4(1):50-61.
2003: Jean-François Goossens; jerome kluza; Hervé Vezin; Mostafa Kouach; Gilbert Briand; Brigitte Baldeyrou; Nicole Wattez; Christian Bailly
Plasma stability of two glycosyl indolocarbazole antitumor agents.
Biochemical pharmacology 2003;65(1):25-34.
2002: Aurore Perzyna; Carine Marty; Michaël Facompré; Jean-François Goossens; Nicole Pommery; Pierre Colson; Claude Houssier; Raymond Houssin; Jean-Pierre Hénichart; Christian Bailly
Formaldehyde-induced DNA cross-link of indolizino[1,2-b]quinolines derived from the A-D rings of camptothecin.
Journal of medicinal chemistry 2002;45(26):5809-12.
2002: Amélie Lansiaux; Farial A Tanious; Zohar Mishal; Laurent Dassonneville; Arvind Kumar; Chad E Stephens; Qiyue Hu; David W. Wilson; David W Boykin; Christian Bailly
Distribution of furamidine analogues in tumor cells: targeting of the nucleus or mitochondria depending on the amidine substitution.
Cancer research 2002;62(24):7219-29.
2002: Carolina Carrasco; Frédéric Rosu; Valérie Gabelica; Claude Houssier; Edwin De Pauw; Christiane Garbay-Jaureguiberry; Bernard Roques; David W. Wilson; Jonathan B Chaires; Michael J Waring; Christian Bailly
Tight binding of the antitumor drug ditercalinium to quadruplex DNA.
Chembiochem : a European journal of chemical biology 2002;3(12):1235-41.
2002: Michaël Facompré; Brigitte Baldeyrou; Christian Bailly; Fabrice Anizon; Christelle Marminon; Michelle Prudhomme; Pierre Colson; Claude Houssier
DNA targeting of two new antitumour rebeccamycin derivatives.
European journal of medicinal chemistry 2002;37(12):925-32.
2002: Hervé Vezin; Eric Lamour; Sylvain Routier; Françoise Villain; Christian Bailly; Jean-Luc Bernier; Jean Pierre Catteau
Free radical production by hydroxy-salen manganese complexes studied by ESR and XANES.
Journal of inorganic biochemistry 2002;92(3-4):177-82.
2002: Binh Nguyen; Michael P H Lee; Donald Hamelberg; Alexandra Joubert; Christian Bailly; Reto Brun; Stephen Neidle; David W. Wilson
Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove.
Journal of the American Chemical Society 2002;124(46):13680-1.
2002: Michaël Facompre; Carolina Carrasco; Pierre Colson; Claude Houssier; John D Chisholm; David L Van Vranken; Christian Bailly
DNA binding and topoisomerase I poisoning activities of novel disaccharide indolocarbazoles.
Molecular pharmacology 2002;62(5):1215-27.
2002: Marie-Hélène David-Cordonnier; William Laine; Amélie Lansiaux; Mostafa Kouach; Gilbert Briand; Alain Pierré; John A Hickman; Christian Bailly
Alkylation of guanine in DNA by S23906-1, a novel potent antitumor compound derived from the plant alkaloid acronycine.
Biochemistry 2002;41(31):9911-20.
2002: Tim H M Jonckers; Sabine van Miert; Kanyanga Cimanga; Christian Bailly; Pierre Colson; Marie-Claire De Pauw-Gillet; Hilde Van den Heuvel; Magda Claeys; filip Lemiere; Eddy L Esmans; Jef Rozenski; Ludo Quirijnen; Louis Maes; Roger Dommisse; Guy Lemière; Arnold Vlietinck; Luc Pieters
Synthesis, cytotoxicity, and antiplasmodial and antitrypanosomal activity of new neocryptolepine derivatives.
Journal of medicinal chemistry 2002;45(16):3497-508.
2002: Stephen D G Crow; Christian Bailly; Christiane Garbay-Jaureguiberry; Bernard Roques; Barbara Ramsay Shaw; Michael J Waring
DNA sequence recognition by the antitumor drug ditercalinium.
Biochemistry 2002;41(27):8672-82.
2002: Amélie Lansiaux; Christian Bailly; Claude Houssier; Pierre Colson; Marie-Claire De Pauw-Gillet; Michel Frederich; Monique Tits; Luc Angenot
Apoptosis of HL-60 leukemia cells induced by the bisindole alkaloids sungucine and isosungucine from Strychnos icaja.
Planta medica 2002;68(7):591-5.
2002: Amélie Lansiaux; Laurent Dassonneville; Michaël Facompré; Arvind Kumar; Chad E Stephens; Miroslav Bajic; Farial A Tanious; David W. Wilson; David W Boykin; Christian Bailly
Distribution of furamidine analogues in tumor cells: influence of the number of positive charges.
Journal of medicinal chemistry 2002;45(10):1994-2002.
2002: Christelle Marminon; Michaël Facompré; Christian Bailly; John Hickman; Alain Pierré; Bruno Pfeiffer; Pierre Renard; Michelle Prudhomme
Dimers from dechlorinated rebeccamycin: synthesis, interaction with DNA, and antiproliferative activities.
European journal of medicinal chemistry 2002;37(5):435-40.
2002: jerome kluza; Amélie Lansiaux; Nicole Wattez; Marie-Paule Hildebrand; Stéphane Léonce; Alain Pierré; John A Hickman; Christian Bailly
Induction of apoptosis in HL-60 leukemia and B16 melanoma cells by the acronycine derivative S23906-1.
Biochemical pharmacology 2002;63(8):1443-52.
2002: Carolina Carrasco; Michaël Facompré; John D Chisholm; David L Van Vranken; David W. Wilson; Christian Bailly
DNA sequence recognition by the indolocarbazole antitumor antibiotic AT2433-B1 and its diastereoisomer.
Nucleic acids research 2002;30(8):1774-81.
2002: Binh Nguyen; Christelle Tardy; Christian Bailly; Pierre Colson; Claude Houssier; Arvind Kumar; David W Boykin; David W. Wilson
Influence of compound structure on affinity, sequence selectivity, and mode of binding to DNA for unfused aromatic dications related to furamidine.
Biopolymers 2002;63(5):281-97.
2002: Brigitte Baldeyrou; Christelle Tardy; Christian Bailly; Pierre Colson; Claude Houssier; Franck Charmantray; Martine Demeunynck
Synthesis and DNA interaction of a mixed proflavine-phenanthroline Tröger base.
European journal of medicinal chemistry 2002;37(4):315-22.
2002: Lei Wang; Arvind Kumar; David W Boykin; Christian Bailly; David W. Wilson
Comparative thermodynamics for monomer and dimer sequence-dependent binding of a heterocyclic dication in the DNA minor groove.
Journal of molecular biology 2002;317(3):361-74.
2001: Pascale Moreau; Martine Sancelme; Christian Bailly; Stéphane Léonce; Alain Pierré; John Hickman; Bruno Pfeiffer; Michelle Prudhomme
Synthesis and biological activities of indolocarbazoles bearing amino acid residues.
European journal of medicinal chemistry 2001;36(11-12):887-97.
2001: Paola B Arimondo; Brigitte Baldeyrou; William Laine; Christine Bal; F A Alphonse; Sylvain Routier; Gérard Coudert; Jean-Yves Mérour; Pierre Colson; Claude Houssier; Christian Bailly
DNA interaction and cytotoxicity of a new series of indolo[2,3-b]quinoxaline and pyridopyrazino[2,3-b]indole derivatives.
Chemico-biological interactions 2001;138(1):59-75.
2001: B Pilch; eric Allemand; M Facompré; Christian Bailly; Jean-François Riou; Johann Soret; Jamal Tazi
Specific inhibition of serine- and arginine-rich splicing factors phosphorylation, spliceosome assembly, and splicing by the antitumor drug NB-506.
Cancer research 2001;61(18):6876-84.
2001: Amélie Lansiaux; Michaël Facompré; Nicole Wattez; Marie-Paule Hildebrand; Christine Bal; Danièle Demarquay; Olivier Lavergne; Dennis Bigg; Christian Bailly
Apoptosis induced by the homocamptothecin anticancer drug BN80915 in HL-60 cells.
Molecular pharmacology 2001;60(3):450-61.
2001: Christian Bailly; Christelle Tardy; L Wang; Bruce A Armitage; K Hopkins; Arvind Kumar; Gary B Schuster; David W Boykin; David W. Wilson
Recognition of ATGA sequences by the unfused aromatic dication DB293 forming stacked dimers in the DNA minor groove.
Biochemistry 2001;40(33):9770-9.
2001: P Bilik; Farial A Tanious; Arvind Kumar; David W. Wilson; David W Boykin; Pierre Colson; Claude Houssier; Michaël Facompré; Christelle Tardy; Christian Bailly
Novel dications with unfused aromatic systems: trithiophene and trifuran derivatives of furimidazoline.
Chembiochem : a European journal of chemical biology 2001;2(7-8):559-69.
2001: Farial A Tanious; David W. Wilson; Donald A Patrick; Richard R Tidwell; Pierre Colson; Claude Houssier; Christelle Tardy; Christian Bailly
Sequence-dependent binding of bis-amidine carbazole dications to DNA.
European journal of biochemistry / FEBS 2001;268(12):3455-64.
2001: B Joseph; Michaël Facompré; H Da Costa; Sylvain Routier; Jean-Yves Mérour; Pierre Colson; Claude Houssier; Christian Bailly
Synthesis, cytotoxicity, DNA interaction and topoisomerase II inhibition properties of tetrahydropyrrolo[3,4-a]carbazole-1,3-dione and tetrahydropyrido-[3,2-b]pyrrolo[3,4-g]indole-1,3-dione derivatives.
Bioorganic & medicinal chemistry 2001;9(6):1533-41.
2001: Jean-François Goossens; E Bouey-Bencteux; Raymond Houssin; Jean-Pierre Hénichart; Pierre Colson; Claude Houssier; William Laine; Brigitte Baldeyrou; Christian Bailly
DNA interaction of the tyrosine protein kinase inhibitor PD153035 and its N-methyl analogue.
Biochemistry 2001;40(15):4663-71.
2001: Carolina Carrasco; Hervé Vezin; David W. Wilson; J Ren; Jonathan B Chaires; Christian Bailly
DNA binding properties of the indolocarbazole antitumor drug NB-506.
Anti-cancer drug design 2001;16(2-3):99-107.
2001: Lei Wang; C Carrasco; Arvind Kumar; Chad E Stephens; Christian Bailly; David W Boykin; David W. Wilson
Evaluation of the influence of compound structure on stacked-dimer formation in the DNA minor groove.
Biochemistry 2001;40(8):2511-21.
2001: K Li; T M Davis; Christian Bailly; Arvind Kumar; David W Boykin; David W. Wilson
A heterocyclic inhibitor of the REV-RRE complex binds to RRE as a dimer.
Biochemistry 2001;40(5):1150-8.
2001: Christian Bailly; William Laine; Brigitte Baldeyrou; Danièle Demarquay; Marion Huchet; Hélène Coulomb; Christophe Lanco; Olivier Lavergne; Dennis Bigg
A novel B-ring modified homocamptothecin, 12-Cl-hCPT, showing antiproliferative and topoisomerase I inhibitory activities superior to SN-38.
Anti-cancer drug design 2001;16(1):27-36.
2001: Aline Voldoire; Martine Sancelme; Michelle Prudhomme; P Colson; Claude Houssier; Christian Bailly; Stéphane Léonce; S Lambel
Rebeccamycin analogues from indolo[2,3-c]carbazole.
Bioorganic & medicinal chemistry 2001;9(2):357-65.
2001: M Facompre; J F Goossens; Christian Bailly
Apoptotic response of HL-60 human leukemia cells to the antitumor drug NB-506, a glycosylated indolocarbazole inhibitor of topoisomerase 1.
Biochemical pharmacology 2001;61(3):299-310.
2001: Yoshimasa Urasaki; Gary S Laco; Y Takebayashi; Christian Bailly; Glenda Kohlhagen; Yves Pommier
Use of camptothecin-resistant mammalian cell lines to evaluate the role of topoisomerase I in the antiproliferative activity of the indolocarbazole, NB-506, and its topoisomerase I binding site.
Cancer research 2001;61(2):504-8.
2001: Amélie Lansiaux; R A Bras-Goncalves; Christophe Rosty; P Laurent-Puig; Marie-France Poupon; Christian Bailly
Topoisomerase I-DNA covalent complexes in human colorectal cancer xenografts with different p53 and microsatellite instability status: relation with their sensitivity to CTP-11.
Anticancer research 2001;21(1A):471-6.
2001: Danièle Demarquay; Marion Huchet; Hélène Coulomb; Laurence Lesueur-Ginot; Olivier Lavergne; Philip G Kasprzyk; Christian Bailly; Jose CAMARA; Dennis Bigg
The homocamptothecin BN 80915 is a highly potent orally active topoisomerase I poison.
Anti-cancer drugs 2001;12(1):9-19.
2001: Amélie Lansiaux; William Laine; Brigitte Baldeyrou; Christine Mahieu; Nicole Wattez; Hervé Vezin; Fernando J Martinez; A Piñeyro; Christian Bailly
DNA topoisomerase II inhibition by peroxisomicine A(1) and its radical metabolite induces apoptotic cell death of HL-60 and HL-60/MX2 human leukemia cells.
Chemical research in toxicology 2001;14(1):16-24.
2000: Paola B Arimondo; Chawki Boukarim; Christian Bailly; Daniel Dauzonne; Claude Monneret
Design of two etoposide-amsacrine conjugates: topoisomerase II and tubuline polymerization inhibition and relation to cytotoxicity.
Anti-cancer drug design 2000;15(6):413-21.
2000: Laurent Dassonneville; Amélie Lansiaux; A Wattelet; Nicole Wattez; Christine Mahieu; Sabine van Miert; Luc Pieters; Christian Bailly
Cytotoxicity and cell cycle effects of the plant alkaloids cryptolepine and neocryptolepine: relation to drug-induced apoptosis.
European journal of pharmacology 2000;409(1):9-18.
2000: Christian Bailly; Jean-François Goossens; William Laine; Fabrice Anizon; Michelle Prudhomme; J Ren; Jonathan B Chaires
Formaldehyde-induced alkylation of a 2'-aminoglucose rebeccamycin derivative to both A.T and G.C base pairs in DNA.
Journal of medicinal chemistry 2000;43(24):4711-20.
2000: Farial A Tanious; D Ding; Donald A Patrick; Christian Bailly; Richard R Tidwell; David W. Wilson
Effects of compound structure on carbazole dication-DNA complexes: tests of the minor-groove complex models.
Biochemistry 2000;39(39):12091-101.
2000: J Benoit; Sylvain Routier; Jean-Yves Mérour; Pierre Colson; Claude Houssier; Christian Bailly
DNA but not topoisomerases is a target for a cytotoxic benzo[5,6]cyclohepta[b]indol-6-one derivative.
Anticancer research 2000;20(5A):3307-14.
2000: Laurent Dassonneville; Nicole Wattez; Brigitte Baldeyrou; Christine Mahieu; Amélie Lansiaux; Bernard Banaigs; Isabelle Bonnard; Christian Bailly
Inhibition of topoisomerase II by the marine alkaloid ascididemin and induction of apoptosis in leukemia cells.
Biochemical pharmacology 2000;60(4):527-37.
2000: Christian Bailly; S Crow; A Minnock; Michael J Waring
DNA recognition by quinoline antibiotics: use of base-modified DNA molecules to investigate determinants of sequence-specific binding of luzopeptin.
Nucleosides, nucleotides & nucleic acids 2000;19(8):1337-53.
2000: jerome kluza; Amélie Lansiaux; Nicole Wattez; Christine Mahieu; N Osheroff; Christian Bailly
Apoptotic response of HL-60 human leukemia cells to the antitumor drug TAS-103.
Cancer research 2000;60(15):4077-84.
2000: Christian Bailly; William Laine; Martine Demeunynck; Jean Lhomme
Enantiospecific recognition of DNA sequences by a proflavine Tröger base.
Biochemical and biophysical research communications 2000;273(2):681-5.
2000: Michaël Facompré; Nicole Wattez; jerome kluza; Amélie Lansiaux; Christian Bailly
Relationship between cell cycle changes and variations of the mitochondrial membrane potential induced by etoposide.
Molecular cell biology research communications : MCBRC 2000;4(1):37-42.
2000: Christian Bailly; William Laine; Brigitte Baldeyrou; Marie-Claire De Pauw-Gillet; Pierre Colson; Claude Houssier; Kanyanga Cimanga; Sabine van Miert; Arnold Vlietinck; Luc Pieters
DNA intercalation, topoisomerase II inhibition and cytotoxic activity of the plant alkaloid neocryptolepine.
Anti-cancer drug design 2000;15(3):191-201.
2000: Olivier Lavergne; Danièle Demarquay; Christian Bailly; Christophe Lanco; A Rolland; Marion Huchet; Hélène Coulomb; N Muller; N Baroggi; Jose CAMARA; C Le Breton; E Manginot; J B Cazaux; Dennis Bigg
Topoisomerase I-mediated antiproliferative activity of enantiomerically pure fluorinated homocamptothecins.
Journal of medicinal chemistry 2000;43(11):2285-9.
2000: Jean-François Goossens; Jean-Pierre Hénichart; Laurent Dassonneville; Michaël Facompré; Christian Bailly
Relation between intracellular acidification and camptothecin-induced apoptosis in leukemia cells.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;10(2):125-31.
2000: Jinsong Ren; Christian Bailly; Jonathan B Chaires
NB-506, an indolocarbazole topoisomerase I inhibitor, binds preferentially to triplex DNA.
FEBS letters 2000;470(3):355-9.
2000: F Dudouit; Jean-François Goossens; Raymond Houssin; Jean-Pierre Hénichart; Pierre Colson; Claude Houssier; N Gelus; Christian Bailly
Synthesis, DNA binding, topoisomerases inhibition and cytotoxic properties of 4-arylcarboxamidopyrrolo-2-carboxyanilides.
Bioorganic & medicinal chemistry letters 2000;10(6):553-7.
2000: Philippe Helissey; Sylviane Giorgi-Renault; Pierre Colson; Claude Houssier; Christian Bailly
Sequence-recognition and cleavage of DNA by a netropsin-phenazine-di-N-oxide conjugate.
Bioconjugate chemistry 2000;11(2):219-27.
2000: Jean-François Goossens; Jean-Pierre Hénichart; Fabrice Anizon; Michelle Prudhomme; C Dugave; J Riou; Christian Bailly
Cellular uptake and interaction with purified membranes of rebeccamycin derivatives.
European journal of pharmacology 2000;389(2-3):141-6.
2000: Lei Wang; Christian Bailly; Arvind Kumar; D Ding; Miroslav Bajic; David W Boykin; David W. Wilson
Specific molecular recognition of mixed nucleic acid sequences: an aromatic dication that binds in the DNA minor groove as a dimer.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(1):12-6.
1999: A Minnock; S Crow; Christian Bailly; Michael J Waring
The influence of the exocyclic pyrimidine 5-methyl group on DNAse I cleavage and sequence recognition by drugs.
Biochimica et biophysica acta 1999;1489(2-3):233-48.
1999: Christian Bailly; Amélie Lansiaux; Laurent Dassonneville; Danièle Demarquay; Hélène Coulomb; Marion Huchet; Olivier Lavergne; Dennis Bigg
Homocamptothecin, an E-ring-modified camptothecin analogue, generates new topoisomerase I-mediated DNA breaks.
Biochemistry 1999;38(47):15556-63.
1999: Laurent Dassonneville; Nicole Wattez; Christine Mahieu; Pierre Colson; Claude Houssier; Michel Frederich; Monique Tits; Luc Angenot; Christian Bailly
The plant alkaloid usambarensine intercalates into DNA and induces apoptosis in human HL60 leukemia cells.
Anticancer research 1999;19(6B):5245-50.
1999: Sylvain Routier; Hervé Vezin; Eric Lamour; Jean-Luc Bernier; Jean Pierre Catteau; Christian Bailly
DNA cleavage by hydroxy-salicylidene-ethylendiamine-iron complexes.
Nucleic acids research 1999;27(21):4160-6.
1999: Laurent Dassonneville; Christian Bailly
Stimulation of topoisomerase II-mediated DNA cleavage by an indazole analogue of lucanthone.
Biochemical pharmacology 1999;58(8):1307-12.
1999: Xiaogang Qu; Jonathan B Chaires; Mitsuru Ohkubo; T Yoshinari; Susumu Nishimura; Christian Bailly
A DNA binding indolocarbazole disaccharide derivative remains highly cytotoxic without inhibiting topoisomerase I.
Anti-cancer drug design 1999;14(5):433-42.
1999: Christian Bailly; S Crow; A Minnock; Michael J Waring
Demethylation of thymine residues affects DNA cleavage by endonucleases but not sequence recognition by drugs.
Journal of molecular biology 1999;291(3):561-73.
1999: Christian Bailly; Xiaogang Qu; Jonathan B Chaires; Pierre Colson; Claude Houssier; Mitsuru Ohkubo; Susumu Nishimura; T Yoshinari
Substitution at the F-ring N-imide of the indolocarbazole antitumor drug NB-506 increases the cytotoxicity, DNA binding, and topoisomerase I inhibition activities.
Journal of medicinal chemistry 1999;42(15):2927-35.
1999: M O Catrycke; Raymond Houssin; Jean-Pierre Hénichart; B Pfeiffer; Pierre Renard; Laurent Dassonneville; Christian Bailly
Synthesis and cytotoxicity of analogues of the antibiotic BE 10988 inhibitors of DNA topoisomerase II.
Bioorganic & medicinal chemistry letters 1999;9(14):2025-30.
1999: Christian Bailly; Carolina Carrasco; F Hamy; Hervé Vezin; Michelle Prudhomme; A Saleem; E Rubin
The camptothecin-resistant topoisomerase I mutant F361S is cross-resistant to antitumor rebeccamycin derivatives. A model for topoisomerase I inhibition by indolocarbazoles.
Biochemistry 1999;38(27):8605-11.
1999: Laurent Dassonneville; Karine Bonjean; Marie-Claire De Pauw-Gillet; Pierre Colson; Claude Houssier; Joëlle Quetin-Leclercq; Luc Angenot; Christian Bailly
Stimulation of topoisomerase II-mediated DNA cleavage by three DNA-intercalating plant alkaloids: cryptolepine, matadine, and serpentine.
Biochemistry 1999;38(24):7719-26.
1999: Laurence Lesueur-Ginot; Danièle Demarquay; Robert Kiss; Philip G Kasprzyk; Laurent Dassonneville; Christian Bailly; Jose CAMARA; Olivier Lavergne; Dennis Bigg
Homocamptothecin, an E-ring modified camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and antitumor properties.
Cancer research 1999;59(12):2939-43.
1999: Christian Bailly; Laurent Dassonneville; Pierre Colson; Claude Houssier; Kazuhiro Fukasawa; Susumu Nishimura; T Yoshinari
Intercalation into DNA is not required for inhibition of topoisomerase I by indolocarbazole antitumor agents.
Cancer research 1999;59(12):2853-60.
1999: Pascale Moreau; Fabrice Anizon; Martine Sancelme; Michelle Prudhomme; D Sevère; Jean-François Riou; Jean-François Goossens; Jean-Pierre Hénichart; Christian Bailly; E Labourier; J Tazzi; Doriano Fabbro; T Meyer; AM Aubertin
Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives.
Journal of medicinal chemistry 1999;42(10):1816-22.
1999: Pascale Moreau; Fabrice Anizon; Martine Sancelme; Michelle Prudhomme; Christian Bailly; D Sevère; Jean-François Riou; Doriano Fabbro; T Meyer; AM Aubertin
Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent.
Journal of medicinal chemistry 1999;42(4):584-92.
1999: Christian Bailly; Laurent Dassonneville; C Carrasco; D Lucas; A Kumar; David W Boykin; David W. Wilson
Relationships between topoisomerase II inhibition, sequence-specificity and DNA binding mode of dicationic diphenylfuran derivatives.
Anti-cancer drug design 1999;14(1):47-60.
1999: Christian Bailly; Xiaogang Qu; Fabrice Anizon; Michelle Prudhomme; Jean-François Riou; Jonathan B Chaires
Enhanced binding to DNA and topoisomerase I inhibition by an analog of the antitumor antibiotic rebeccamycin containing an amino sugar residue.
Molecular pharmacology 1999;55(2):377-85.
1999: E Labourier; Jean-François Riou; Michelle Prudhomme; C Carrasco; Christian Bailly; Jamal Tazi
Poisoning of topoisomerase I by an antitumor indolocarbazole drug: stabilization of topoisomerase I-DNA covalent complexes and specific inhibition of the protein kinase activity.
Cancer research 1999;59(1):52-5.
1998: Claudia Sissi; L Bolgan; Stefano Moro; Giuseppe Zagotto; Christian Bailly; Ernesto Menta; Giovanni Capranico; Manlio Palumbo
DNA-binding preferences of bisantrene analogues: relevance to the sequence specificity of drug-mediated topoisomerase II poisoning.
Molecular pharmacology 1998;54(6):1036-45.
1998: Fabrice Anizon; Pascale Moreau; Martine Sancelme; Aline Voldoire; Michelle Prudhomme; M Ollier; D Sevère; Jean-François Riou; Christian Bailly; Doriano Fabbro; T Meyer; AM Aubertin
Syntheses, biochemical and biological evaluation of staurosporine analogues from the microbial metabolite rebeccamycin.
Bioorganic & medicinal chemistry 1998;6(9):1597-604.
1998: Sylvain Routier; Jean-Luc Bernier; Jean Pierre Catteau; J F Riou; Christian Bailly
Synthesis, DNA binding, topoisomerase II inhibition and cytotoxicity of two guanidine-containing anthracene-9,10-diones.
Anti-cancer drug design 1998;13(5):407-15.
1998: Pascale Moreau; Fabrice Anizon; Martine Sancelme; Michelle Prudhomme; Christian Bailly; C Carrasco; M Ollier; D Sevère; Jean-François Riou; Doriano Fabbro; T Meyer; AM Aubertin
Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle.
Journal of medicinal chemistry 1998;41(10):1631-40.
1998: Karine Bonjean; Marie-Claire De Pauw-Gillet; Marie-Paule Defresne; Pierre Colson; Claude Houssier; Laurent Dassonneville; Christian Bailly; Roland Greimers; C Wright; Joëlle Quetin-Leclercq; Monique Tits; Luc Angenot
The DNA intercalating alkaloid cryptolepine interferes with topoisomerase II and inhibits primarily DNA synthesis in B16 melanoma cells.
Biochemistry 1998;37(15):5136-46.
1998: Carolina Carrasco; M J Waring; Christian Bailly
Substitution of 5-methylcytosines for cytosines enhances the stability of topoisomerase I-DNA complexes and modulates the sequence selectivity of camptothecin-induced DNA cleavage.
FEBS letters 1998;425(2):337-40.
1998: Christian Bailly; M J Waring
DNA recognition by quinoxaline antibiotics: use of base-modified DNA molecules to investigate determinants of sequence-specific binding of triostin A and TANDEM.
The Biochemical journal 1998;330 ( Pt 1)():81-7.
1998: Christian Bailly; B Viossat; X Labouze; G Morgant; C Saturnino; J C Lancelot; M Robba; N H Dung
Synthesis, Crystal Structure and Interaction With DNA of N,N'-(Butane-1,4-Diyl)Bis(Guanidinium) Tetrachloroplatinate (II).
Metal-based drugs 1998;5(5):279-85.
1998: Christian Bailly; Pierre Colson; Claude Houssier; E Rodrigues-Pereira; M Prudhomme; M J Waring
Recognition of specific sequences in DNA by a topoisomerase I inhibitor derived from the antitumor drug rebeccamycin.
Molecular pharmacology 1998;53(1):77-87.
1997: Laurent Dassonneville; F Hamy; Pierre Colson; Claude Houssier; Christian Bailly
Binding of Hoechst 33258 to the TAR RNA of HIV-1. Recognition of a pyrimidine bulge-dependent structure.
Nucleic acids research 1997;25(22):4487-92.
1997: Sylvain Routier; Jean-Luc Bernier; Jean Pierre Catteau; Pierre Colson; Claude Houssier; C Rivalle; E Bisagni; Christian Bailly
Synthesis, DNA binding, and cleaving properties of an ellipticine-salen.copper conjugate.
Bioconjugate chemistry 1997;8(6):789-92.
1997: Fabrice Anizon; L Belin; Pascale Moreau; Martine Sancelme; Aline Voldoire; Michelle Prudhomme; M Ollier; D Sevère; Jean-François Riou; Christian Bailly; Doriano Fabbro; T Meyer
Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.
Journal of medicinal chemistry 1997;40(21):3456-65.
1997: Michael J Waring; Christian Bailly
The influence of the exocyclic amino group characteristic of GC base pairs on molecular recognition of specific nucleotide sequences in DNA by berenil and DAPI.
Journal of molecular recognition : JMR 1997;10(3):121-7.
1997: J P Henichart; M J Waring; J F Riou; W A Denny; Christian Bailly
Copper-dependent oxidative and topoisomerase II-mediated DNA cleavage by a netropsin/4'-(9-acridinylamino)methanesulfon-m-anisidide combilexin.
Molecular pharmacology 1997;51(3):448-61.
1996: Christian Bailly; W A Denny; M J Waring
Molecular origins of selectivity in the interaction of amsacrine-4-carboxamide with GC-rich sequences in DNA.
Anti-cancer drug design 1996;11(8):611-24.
1996: Christian Bailly; D Payet; A A Travers; Michael J Waring
PCR-based development of DNA substrates containing modified bases: an efficient system for investigating the role of the exocyclic groups in chemical and structural recognition by minor groove binding drugs and proteins.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):13623-8.
1996: Christian Bailly; A Minnock; M J Waring
A simple ligation assay to detect effects of drugs on the curvature/flexibility of DNA.
FEBS letters 1996;396(2-3):253-6.
1996: C Bourdouxhe-Housiaux; Pierre Colson; Claude Houssier; Christian Bailly
Interaction of DNA-threading peptide-amsacrine conjugates with DNA and chromatin.
Anti-cancer drug design 1996;11(7):509-25.
1996: Christian Bailly; M Braña; Michael J Waring
Sequence-selective intercalation of antitumour bis-naphthalimides into DNA. Evidence for an approach via the major groove.
European journal of biochemistry / FEBS 1996;240(1):195-208.
1996: Sylvain Routier; N Cotelle; Jean Pierre Catteau; Jean-Luc Bernier; M J Waring; J F Riou; Christian Bailly
Salen-anthraquinone conjugates. Synthesis, DNA-binding and cleaving properties, effects on topoisomerases and cytotoxicity.
Bioorganic & medicinal chemistry 1996;4(8):1185-96.
1996: C Marchand; Christian Bailly; Chi Hung Nguyen; Emile Bisagni; Thérèse Garestier; Claude Hélène; Michael J Waring
Stabilization of triple helical DNA by a benzopyridoquinoxaline intercalator.
Biochemistry 1996;35(15):5022-32.
1996: Christian Bailly; Pierre Colson; Claude Houssier; F Hamy
The binding mode of drugs to the TAR RNA of HIV-1 studied by electric linear dichroism.
Nucleic acids research 1996;24(8):1460-4.
1996: C Bourdouxhe-Housiaux; Pierre Colson; Claude Houssier; Michael J Waring; Christian Bailly
Interaction of a DNA-threading netropsin-amsacrine combilexin with DNA and chromatin.
Biochemistry 1996;35(14):4251-64.
1996: Christian Bailly; Sylvain Routier; Jean-Luc Bernier; M J Waring
DNA recognition by two mitoxantrone analogues: influence of the hydroxyl groups.
FEBS letters 1996;379(3):269-72.
1996: Christian Bailly; F Hamy; Michael J Waring
Cooperativity in the binding of echinomycin to DNA fragments containing closely spaced CpG sites.
Biochemistry 1996;35(4):1150-61.
1996: Pierre Colson; Christian Bailly; Claude Houssier
Electric linear dichroism as a new tool to study sequence preference in drug binding to DNA.
Biophysical chemistry 1996;58(1-2):125-40.
1995: Christian Bailly; Michael J Waring; A A Travers
Effects of base substitutions on the binding of a DNA-bending protein.
Journal of molecular biology 1995;253(1):1-7.
1995: Pierre Colson; Claude Houssier; Christian Bailly
Use of electric linear dichroism and competition experiments with intercalating drugs to investigate the mode of binding of Hoechst 33258, berenil and DAPI to GC sequences.
Journal of biomolecular structure & dynamics 1995;13(2):351-66.
1995: Christian Bailly; A Kénani; M J Waring
Analogue versus digital recognition of DNA by bleomycin: an effect of the carbohydrate moiety.
FEBS letters 1995;372(2-3):144-7.
1995: Christian Bailly; C Marchand; C Hung Nguyen; Emile Bisagni; Thérèse Garestier; Claude Hélène; Michael J Waring
Localized chemical reactivity in double-stranded DNA associated with the intercalative binding of benzo[e]pyridoindole and benzo[g]pyridoindole triple-helix-stabilizing ligands.
European journal of biochemistry / FEBS 1995;232(1):66-76.
1995: Christian Bailly; N E Møllegaard; P E Nielsen; Michael J Waring
The influence of the 2-amino group of guanine on DNA conformation. Uranyl and DNase I probing of inosine/diaminopurine substituted DNA.
The EMBO journal 1995;14(9):2121-31.
1995: Christian Bailly; Michael J Waring
Transferring the purine 2-amino group from guanines to adenines in DNA changes the sequence-specific binding of antibiotics.
Nucleic acids research 1995;23(6):885-92.
1995: Bertrand Plouvier; Raymond Houssin; Nicole Helbecque; Pierre Colson; Claude Houssier; Jean-Pierre Hénichart; Christian Bailly
Influence of the methyl substituents of a thiazole-containing lexitropsin on the mode of binding to DNA.
Anti-cancer drug design 1995;10(2):155-66.
1995: C Bourdouxhe; Pierre Colson; Claude Houssier; Jean-Pierre Hénichart; Michael J Waring; W A Denny; Christian Bailly
Design of composite drug molecules: mutual effects on binding to DNA of an intercalator, amsacrine, and a minor groove binder, netropsin.
Anti-cancer drug design 1995;10(2):131-54.
1995: Christian Bailly; Michael J Waring
Comparison of different footprinting methodologies for detecting binding sites for a small ligand on DNA.
Journal of biomolecular structure & dynamics 1995;12(4):869-98.
1994: Christian Bailly; C Michaux; Pierre Colson; Claude Houssier; Jian-Sheng Sun; Thérèse Garestier; Claude Hélène; Jean-Pierre Hénichart; C Rivalle; Emile Bisagni
Reaction of a biscationic distamycin-ellipticine hybrid ligand with DNA. Mode and sequence specificity of binding.
Biochemistry 1994;33(51):15348-64.
1994: G S Ridge; Christian Bailly; D E Graves; Michael J Waring
Daunomycin modifies the sequence-selective recognition of DNA by actinomycin.
Nucleic acids research 1994;22(24):5241-6.
1994: Michael J Waring; Christian Bailly
The purine 2-amino group as a critical recognition element for binding of small molecules to DNA.
Gene 1994;149(1):69-79.
1994: Bertrand Plouvier; Raymond Houssin; B Hecquet; Pierre Colson; Claude Houssier; M J Waring; Jean-Pierre Hénichart; Christian Bailly
Antitumor combilexin. A thiazole-containing analogue of netropsin linked to an acridine chromophore.
Bioconjugate chemistry 1994;5(5):475-81.
1994: Christian Bailly; I O Donkor; D Gentle; M Thornalley; Michael J Waring
Sequence-selective binding to DNA of cis- and trans- butamidine analogues of the anti-Pneumocystis carinii pneumonia drug pentamidine.
Molecular pharmacology 1994;46(2):313-22.
1994: Christian Bailly; D E Graves; G Ridge; Michael J Waring
Use of a photoactive derivative of actinomycin to investigate shuffling between binding sites on DNA.
Biochemistry 1994;33(29):8736-45.
1994: K E Rao; Gilles Gosselin; D Mrani; Christian Périgaud; Jean-Louis Imbach; Christian Bailly; Jean-Pierre Hénichart; P Colson; Claude Houssier; J W Lown
Psoralen--lexitropsin hybrids: DNA sequence selectivity of photoinduced cross-linking from MPE footprinting and exonuclease III stop assay, and mode of binding from electric linear dichroism.
Anti-cancer drug design 1994;9(3):221-37.
1994: Michael J Waring; Christian Bailly
DNA recognition by intercalators and hybrid molecules.
Journal of molecular recognition : JMR 1994;7(2):109-22.
1994: Christian Bailly; D Gentle; F Hamy; M Purcell; Michael J Waring
Localized chemical reactivity in DNA associated with the sequence-specific bisintercalation of echinomycin.
The Biochemical journal 1994;300 ( Pt 1)():165-73.
1994: S Flock; F Bailly; Christian Bailly; Michael J Waring; Jean-Pierre Hénichart; Pierre Colson; Claude Houssier
Interaction of two peptide-acridine conjugates containing the SPKK peptide motif with DNA and chromatin.
Journal of biomolecular structure & dynamics 1994;11(4):881-900.
1993: Christian Bailly; Michael J Waring
Preferential intercalation at AT sequences in DNA by lucanthone, hycanthone, and indazole analogs. A footprinting study.
Biochemistry 1993;32(23):5985-93.
1993: F Bailly; Christian Bailly; Pierre Colson; Claude Houssier; Jean-Pierre Hénichart
A tandem repeat of the SPKK peptide motif induces psi-type DNA structures at alternating AT sequences.
FEBS letters 1993;324(2):181-4.
1993: Christian Bailly; V Leclere; Nicole Pommery; Pierre Colson; Claude Houssier; C Rivalle; Emile Bisagni; Jean-Pierre Hénichart
Binding to DNA, cellular uptake and biological activity of a distamycin-ellipticine hybrid molecule.
Anti-cancer drug design 1993;8(2):145-64.
1993: Christian Bailly; Alan W Cuthbert; D Gentle; Michael Knowles; Michael J Waring
Sequence-selective binding of amiloride to DNA.
Biochemistry 1993;32(10):2514-24.
1992: Christian Bailly; Jean-Pierre Hénichart; Pierre Colson; Claude Houssier
Drug-DNA sequence-dependent interactions analysed by electric linear dichroism.
Journal of molecular recognition : JMR 1992;5(4):155-71.
1992: C Marchand; Christian Bailly; M J McLean; S E Moroney; Michael J Waring
The 2-amino group of guanine is absolutely required for specific binding of the anti-cancer antibiotic echinomycin to DNA.
Nucleic acids research 1992;20(21):5601-6.
1992: Christian Bailly; P Colson; Claude Houssier; Raymond Houssin; D Mrani; Gilles Gosselin; Jean-Louis Imbach; M J Waring; J W Lown; Jean-Pierre Hénichart
Binding properties and DNA sequence-specific recognition of two bithiazole-linked netropsin hybrid molecules.
Biochemistry 1992;31(35):8349-62.
1992: Christian Bailly; C O'Huigin; Raymond Houssin; Pierre Colson; Claude Houssier; C Rivalle; Emile Bisagni; J P Henichart; Michael J Waring
DNA-binding properties of a distamycin-ellipticine hybrid molecule.
Molecular pharmacology 1992;41(5):845-55.
1992: F Bailly; Christian Bailly; Michael J Waring; Jean-Pierre Hénichart
Selective binding to AT sequences in DNA by an acridine-linked peptide containing the SPKK motif.
Biochemical and biophysical research communications 1992;184(2):930-7.
1992: Christian Bailly; W A Denny; L E Mellor; L P Wakelin; Michael J Waring
Sequence specificity of the binding of 9-aminoacridine- and amsacrine-4-carboxamides to DNA studied by DNase I footprinting.
Biochemistry 1992;31(13):3514-24.
1992: F Bailly; Christian Bailly; Nicole Helbecque; Nicole Pommery; Pierre Colson; Claude Houssier; Jean-Pierre Hénichart
Relationship between DNA-binding and biological activity of anilinoacridine derivatives containing the nucleic acid-binding unit SPKK.
Anti-cancer drug design 1992;7(1):83-100.
1991: Bertrand Plouvier; Christian Bailly; Raymond Houssin; K E Rao; W J Lown; Jean-Pierre Hénichart; M J Waring
DNA-sequence specific recognition by a thiazole analogue of netropsin: a comparative footprinting study.
Nucleic acids research 1991;19(21):5821-9.
1990: Christian Bailly; C OhUigin; C Rivalle; Emile Bisagni; Jean-Pierre Hénichart; Michael J Waring
Sequence-selective binding of an ellipticine derivative to DNA.
Nucleic acids research 1990;18(21):6283-91.
1990: Christian Bailly; Nicole Helbecque; Jean-Pierre Hénichart; P Colson; Claude Houssier; K E Rao; R G Shea; J W Lown
Molecular recognition between oligopeptides and nucleic acids. DNA sequence specificity and binding properties of an acridine-linked netropsin hybrid ligand.
Journal of molecular recognition : JMR 1990;3(1):26-35.
1990: Christian Bailly; J C Beauvillain; Jean-Luc Bernier; Jean-Pierre Hénichart
Plasma membrane perturbations of KB3 cells induced by the bleomycin-iron complex.
Cancer research 1990;50(2):385-92.
1989: Christian Bailly; Nicole Pommery; Raymond Houssin; J P Henichart
Design, synthesis, DNA binding, and biological activity of a series of DNA minor-groove-binding intercalating drugs.
Journal of pharmaceutical sciences 1989;78(11):910-7.
1989: E Morier-Teissier; Christian Bailly; Jean-Luc Bernier; Raymond Houssin; Nicole Helbecque; Jean Pierre Catteau; Pierre Colson; Claude Houssier; Jean-Pierre Hénichart
Synthesis, biological activity and DNA interaction of anilinoacridine and bithiazole peptide derivatives related to the anti-tumor drugs m-AMSA and bleomycin.
Anti-cancer drug design 1989;4(1):37-52.
1989: Christian Bailly; Jean Pierre Catteau; Jean-Pierre Hénichart; K Reszka; R G Shea; K Krowicki; J W Lown
Subcellular distribution of a nitroxide spin-labeled netropsin in living KB cells. Electron paramagnetic resonance and sequence specificity studies.
Biochemical pharmacology 1989;38(10):1625-30.
1989: Christian Bailly; Raymond Houssin; Jean-Luc Bernier; J P Henichart
[Interaction of bleomycin with the plasmid membrane: changes in the fluidity and peroxidation of lipids].
Bulletin du cancer 1989;76(8):835-7.
1988: Christian Bailly; A Kenani; Nicole Helbecque; Jean-Luc Bernier; Raymond Houssin; Jean-Pierre Hénichart
DNA-binding and DNA-cleaving properties of a synthetic model AGAGLU related to the antitumour drugs AMSA and bleomycin.
Biochemical and biophysical research communications 1988;152(2):695-702.
1988: Christian Bailly; Nicole Pommery; J P Henichart
DNA-synthesis and tumor growth inhibitions by AGGA, a bleomycin-amsacrine hybrid derivative.
Cancer letters 1988;38(3):321-8.