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Ian Kimber

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Living Beings

Chemicals & Drugs

Anatomy

Disorders

Concepts & Ideas

Local Lymph Node Assay

Physiology

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Co-Publications
Name
163
Dearman, Rebecca
92
Basketter, David
45
Cumberbatch, Marie
31
Gerberick, Frank
27
Ryan, Cindy
17
Hilton, J
14
Betts, Catherine
11
Griffiths, Christopher
11
Rothwell, Nancy
10
Ashby, John
9
Pinteaux, Emmanuel
9
Orphanides, George
8
Moggs, Jonathan
8
Warbrick, EV
8
Lea, LJ

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Publications

TOP 3
Kimber Ian; Cumberbatch Marie; Dearman Rebecca J
Langerhans cell migration: not necessarily always at the center of the skin sensitization universe.
Dearman R J; Kimber I
Animal models of protein allergenicity: potential benefits, pitfalls and challenges.
Dearman Rebecca Jane; Betts Catherine Jean; Caddick Helen Theresa; Kimber Ian
Cytokine profiling of chemical allergens in mice: impact of mitogen on selectivity of response.

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All Publications

2009: Kimber Ian; Cumberbatch Marie; Dearman Rebecca J
Langerhans cell migration: not necessarily always at the center of the skin sensitization universe.
The Journal of investigative dermatology 2009;129(8):1852-3.
2009: Dearman R J; Kimber I
Animal models of protein allergenicity: potential benefits, pitfalls and challenges.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2009;39(4):458-68.
2009: Dearman Rebecca Jane; Betts Catherine Jean; Caddick Helen Theresa; Kimber Ian
Cytokine profiling of chemical allergens in mice: impact of mitogen on selectivity of response.
Journal of applied toxicology : JAT 2009;29(3):233-41.
2009: Dearman Rebecca J; Cumberbatch Marie; Maxwell Gavin; Basketter David A; Kimber Ian
Toll-like receptor ligand activation of murine bone marrow-derived dendritic cells.
Immunology 2009;126(4):475-84.
2009: Dearman Rebecca Jane; Betts Catherine Jean; Beresford Lorna; Bailey Laura; Caddick Helen Theresa; Kimber Ian
Butyl benzyl phthalate: effects on immune responses to ovalbumin in mice.
Journal of applied toxicology : JAT 2009;29(2):118-25.
2009: Kimber I
6 Conclusions.
Human & experimental toxicology 2009;28(2-3):163.
2009: Basketter David A; McFadden John F; Gerberick Frank; Cockshott Amanda; Kimber Ian
Nothing is perfect, not even the local lymph node assay: a commentary and the implications for REACH.
Contact dermatitis 2009;60(2):65-9.
2008: Dearman Rebecca J; Cumberbatch Marie; Portsmouth Craig; Maxwell Gavin; Basketter David A; Kimber Ian
Synergistic effects of chemical insult and toll-like receptor ligands on dendritic cell activation.
Toxicology in vitro : an international journal published in association with BIBRA 2008;22(8):1927-34.
2008: Kimber I; Basketter D
Thresholds, dose-response relationships and dose metrics in allergic contact dermatitis.
The British journal of dermatology 2008;159(6):1380-1; author reply 1381-2.
2008: Dearman Rebecca Jane; Betts Catherine Jean; Caddick Helen Theresa; Flanagan Brian Francis; Kimber Ian
Cytokine profiling of chemical allergens in mice: measurement of message versus protein.
Toxicology 2008;252(1-3):17-25.
2008: Kimber Ian; Dearman Rebecca J; Basketter David A; Ryan Cindy A; Gerberick G Frank; McNamee Pauline M; Lalko Jon; Api Anne Marie
Dose metrics in the acquisition of skin sensitization: thresholds and importance of dose per unit area.
Regulatory toxicology and pharmacology : RTP 2008;52(1):39-45.
2008: Tsakiri Niki; Kimber Ian; Rothwell Nancy J; Pinteaux Emmanuel
Differential effects of interleukin-1 alpha and beta on interleukin-6 and chemokine synthesis in neurones.
Molecular and cellular neurosciences 2008;38(2):259-65.
2008: Basketter David; Cockshott Amanda; Corsini Emanuela; Gerberick G Frank; Idehara Kenji; Kimber Ian; Van Loveren Henk; Matheson Joanna; Mehling Annette; Omori Takashi; Rovida Costanza; Sozu Takashi; Takeyoshi Masahiro; Casati Silvia
An evaluation of performance standards and non-radioactive endpoints for the local lymph node assay. The report and recommendations of ECVAM Workshop 65.
Alternatives to laboratory animals : ATLA 2008;36(2):243-57.
2008: Kleyn C Elise; Schneider Laura; Saraceno Rosita; Mantovani Cristina; Richards Helen L; Fortune Donal G; Cumberbatch Marie; Dearman Rebecca J; Terenghi Giorgio; Kimber Ian; Griffiths Christopher E M
The effects of acute social stress on epidermal Langerhans' cell frequency and expression of cutaneous neuropeptides.
The Journal of investigative dermatology 2008;128(5):1273-9.
2008: Dearman Rebecca Jane; Beresford Lorna; Bailey Laura; Caddick Helen Theresa; Betts Catherine Jean; Kimber Ian
Di-(2-ethylhexyl) phthalate is without adjuvant effect in mice on ovalbumin.
Toxicology 2008;244(2-3):231-41.
2008: Tsakiri N; Kimber I; Rothwell N J; Pinteaux E
Interleukin-1-induced interleukin-6 synthesis is mediated by the neutral sphingomyelinase/Src kinase pathway in neurones.
British journal of pharmacology 2008;153(4):775-83.
2008: Tsakiri Niki; Kimber Ian; Rothwell Nancy J; Pinteaux Emmanuel
Mechanisms of interleukin-6 synthesis and release induced by interleukin-1 and cell depolarisation in neurones.
Molecular and cellular neurosciences 2008;37(1):110-8.
2007: Betts Catherine J; Dearman Rebecca J; Kimber Ian; Ryan Cindy A; Gerberick G Frank; Lalko Jon; Api Anne Marie
B220 analysis with the local lymph node assay: proposal for a more flexible prediction model.
Journal of applied toxicology : JAT 2007;27(5):506-10.
2007: Basketter David A; Gerberick Frank; Kimber Ian
The local lymph node assay and the assessment of relative potency: status of validation.
Contact dermatitis 2007;57(2):70-5.
2007: Patlewicz G; Aptula A O; Uriarte E; Roberts D W; Kern P S; Gerberick G F; Kimber I; Dearman R J; Ryan C A; Basketter D A
An evaluation of selected global (Q)SARs/expert systems for the prediction of skin sensitisation potential.
SAR and QSAR in environmental research 2007;18(5-6):515-41.
2007: Roberts David W; Patlewicz Grace; Kern Petra S; Gerberick Frank; Kimber Ian; Dearman Rebecca J; Ryan Cindy A; Basketter David A; Aptula Aynur O
Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization.
Chemical research in toxicology 2007;20(7):1019-30.
2007: Rovida Costanza; Basketter David; Casati Silvia; de Silva Odile; Hermans Helma; Kimber Ian; Manou Irene; Weltzien Hans Ulrich; Roggen Erwin
Management of an integrated project (Sens-it-iv) to develop in vitro tests to assess sensitisation.
Alternatives to laboratory animals : ATLA 2007;35(3):317-22.
2007: Ryan Cindy A; Kimber Ian; Basketter David A; Pallardy Marc; Gildea Lucy A; Gerberick G Frank
Dendritic cells and skin sensitization: biological roles and uses in hazard identification.
Toxicology and applied pharmacology 2007;221(3):384-94.
2007: Kimber Ian; Agius Raymond; Basketter David A; Corsini Emanuela; Cullinan Paul; Dearman Rebecca J; Gimenez-Arnau Elena; Greenwell Leona; Hartung Thomas; Kuper Frieke; Maestrelli Piero; Roggen Erwin; Rovida Costanza;
Chemical respiratory allergy: opportunities for hazard identification and characterisation. The report and recommendations of ECVAM workshop 60.
Alternatives to laboratory animals : ATLA 2007;35(2):243-65.
2007: White Jonathan M L; Goon Anthony T J; Jowsey Ian R; Basketter David A; Mak Rose K H; Kimber Ian; McFadden John P
Oral tolerance to contact allergens: a common occurrence? A review.
Contact dermatitis 2007;56(5):247-54.
2007: Dearman R J; Alcocer M J C; Kimber I
Influence of plant lipids on immune responses in mice to the major Brazil nut allergen Ber e 1.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2007;37(4):582-91.
2007: Basketter David; Pease Camilla; Kasting Gerald; Kimber Ian; Casati Silvia; Cronin Mark; Diembeck Walter; Gerberick Frank; Hadgraft Jonathan; Hartung Thomas; Marty Jean-Paul; Nikolaidis Efstathios; Patlewicz Grace; Roberts David; Roggen Erwin; Rovida Costanza; van de Sandt Johannes
Skin sensitisation and epidermal disposition: the relevance of epidermal disposition for sensitisation hazard identification and risk assessment. The report and recommendations of ECVAM workshop 59.
Alternatives to laboratory animals : ATLA 2007;35(1):137-54.
2007: Betts Catherine J; Beresford L; Dearman R J; Lalko J; Api A P; Kimber I
The use of ethanol:diethylphthalate as a vehicle for the local lymph node assay.
Contact dermatitis 2007;56(2):70-5.
2007: Basketter David A; Kimber Ian
Information derived from sensitization test methods: test sensitivity, false positives and false negatives.
Contact dermatitis 2007;56(1):1-4.
2007: Dearman Rebecca J; Kimber Ian
A mouse model for food allergy using intraperitoneal sensitization.
Methods (San Diego, Calif.) 2007;41(1):91-8.
2007: Ryan Cindy A; Chaney Joel G; Gerberick G Frank; Kern Petra S; Dearman Rebecca J; Kimber Ian; Basketter David A
Extrapolating local lymph node assay EC3 values to estimate relative sensitizing potency.
Cutaneous and ocular toxicology 2007;26(2):135-45.
2006: Betts Catherine J; Dearman Rebecca J; Heylings Jon R; Kimber Ian; Basketter David A
Skin sensitization potency of methyl methacrylate in the local lymph node assay: comparisons with guinea-pig data and human experience.
Contact dermatitis 2006;55(3):140-7.
2006: Mainwaring Guy; Lim Fei Ling; Antrobus Kate; Swain Cindy; Clapp Mike; Kimber Ian; Orphanides George; Moggs Jonathan G
Identification of early molecular pathways affected by paraquat in rat lung.
Toxicology 2006;225(2-3):157-72.
2006: Gildea Lucy A; Ryan Cindy A; Foertsch Leslie M; Kennedy Jennifer M; Dearman Rebecca J; Kimber Ian; Gerberick G Frank
Identification of gene expression changes induced by chemical allergens in dendritic cells: opportunities for skin sensitization testing.
The Journal of investigative dermatology 2006;126(8):1813-22.
2006: Cockshott A; Evans P; Ryan C A; Gerberick G F; Betts C J; Dearman R J; Kimber I; Basketter D A
The local lymph node assay in practice: a current regulatory perspective.
Human & experimental toxicology 2006;25(7):387-94.
2006: Jowsey Ian R; Basketter David A; Westmoreland Carl; Kimber Ian
A future approach to measuring relative skin sensitising potency: a proposal.
Journal of applied toxicology : JAT 2006;26(4):341-50.
2006: Stuckey Ruth; Aldridge Tom; Lim Fei Ling; Moore David J; Tinwell Helen; Doherty Nicola; Davies Reginald; Smith Andrew G; Kimber Ian; Ashby John; Orphanides George; Moggs Jonathan G
Induction of iron homeostasis genes during estrogen-induced uterine growth and differentiation.
Molecular and cellular endocrinology 2006;253(1-2):22-9.
2006: Kimber Ian; Dearman Rebecca J; Betts Catherine J; Gerberick G Frank; Ryan Cindy A; Kern Petra S; Patlewicz Grace Y; Basketter David A
The local lymph node assay and skin sensitization: a cut-down screen to reduce animal requirements?
Contact dermatitis 2006;54(4):181-5.
2006: Cumberbatch Marie; Singh Minal; Dearman Rebecca J; Young Helen S; Kimber Ian; Griffiths Christopher E M
Impaired Langerhans cell migration in psoriasis.
The Journal of experimental medicine 2006;203(4):953-60.
2006: Andre Ralph; Moggs Jonathan G; Kimber Ian; Rothwell Nancy J; Pinteaux Emmanuel
Gene regulation by IL-1beta independent of IL-1R1 in the mouse brain.
Glia 2006;53(5):477-83.
2006: Aeby Pierre; Basketter David; Diembeck Walter; Eschrich Dietmar; Gerberick Frank; Itagaki Hiroshi; Kimber Ian; Le Varlet Beatrice; Manou Irene; Paye Marc; Rousset Francoise; Rowland Joanna; Sakaguchi Hitoshi
Dendritic cell research projects.
ALTEX : Alternativen zu Tierexperimenten 2006;23 Suppl():226-8.
2005: Gerberick G Frank; Ryan Cindy A; Kern Petra S; Schlatter Harald; Dearman Rebecca J; Kimber Ian; Patlewicz Grace Y; Basketter David A
Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods.
Dermatitis : contact, atopic, occupational, drug : official journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group 2005;16(4):157-202.
2005: Dearman Rebecca J; Kimber Ian
Characterisation of immune responses to food allergens in mice.
The Proceedings of the Nutrition Society 2005;64(4):426-33.
2005: Ryan Cindy A; Gerberick G Frank; Gildea Lucy A; Hulette Ben C; Betts Catherine J; Cumberbatch Marie; Dearman Rebecca J; Kimber Ian
Interactions of contact allergens with dendritic cells: opportunities and challenges for the development of novel approaches to hazard assessment.
Toxicological sciences : an official journal of the Society of Toxicology 2005;88(1):4-11.
2005: Griffiths C E M; Dearman R J; Cumberbatch M; Kimber I
Cytokines and Langerhans cell mobilisation in mouse and man.
Cytokine 2005;32(2):67-70.
2005: Andre Ralph; Lerouet Dominique; Kimber Ian; Pinteaux Emmanuel; Rothwell Nancy J
Regulation of expression of the novel IL-1 receptor family members in the mouse brain.
Journal of neurochemistry 2005;95(2):324-30.
2005: Currie Richard A; Bombail Vincent; Oliver Jason D; Moore David J; Lim Fei Ling; Gwilliam Victoria; Kimber Ian; Chipman Kevin; Moggs Jonathan G; Orphanides George
Gene ontology mapping as an unbiased method for identifying molecular pathways and processes affected by toxicant exposure: application to acute effects caused by the rodent non-genotoxic carcinogen diethylhexylphthalate.
Toxicological sciences : an official journal of the Society of Toxicology 2005;86(2):453-69.
2005: Cumberbatch Marie; Clelland Kirsty; Dearman Rebecca J; Kimber Ian
Impact of cutaneous IL-10 on resident epidermal Langerhans' cells and the development of polarized immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(1):43-50.
2005: Betts Catherine J; Dearman Rebecca J; Kimber Ian; Maibach Howard I
Potency and risk assessment of a skin-sensitizing disperse dye using the local lymph node assay.
Contact dermatitis 2005;52(5):268-72.
2005: Dearman R J; Humphreys N; Skinner R A; Kimber I
Allergen-induced cytokine phenotypes in mice: role of CD4 and CD8 T cell populations.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2005;35(4):498-505.
2005: Moggs J G; Murphy T C; Lim F L; Moore D J; Stuckey R; Antrobus K; Kimber I; Orphanides G
Anti-proliferative effect of estrogen in breast cancer cells that re-express ERalpha is mediated by aberrant regulation of cell cycle genes.
Journal of molecular endocrinology 2005;34(2):535-51.
2005: Kimber Ian; Dearman Rebecca J
What makes a chemical a respiratory sensitizer?
Current opinion in allergy and clinical immunology 2005;5(2):119-24.
2005: Wang Penglian; Meinhardt Brenda; Andre Ralph; Renshaw Blair R; Kimber Ian; Rothwell Nancy J; Pinteaux Emmanuel
The interleukin-1-related cytokine IL-1F8 is expressed in glial cells, but fails to induce IL-1beta signalling responses.
Cytokine 2005;29(6):245-50.
2005: Casati Silvia; Aeby Pierre; Basketter David A; Cavani Andrea; Gennari Alessandra; Gerberick G Frank; Griem Peter; Hartung Thomas; Kimber Ian; Lepoittevin Jean-Pierre; Meade B Jean; Pallardy Marc; Rougier Nathalie; Rousset Francoise; Rubinstenn Gilles; Sallusto Federica; Verheyen Geert R; Zuang Valérie;
Dendritic cells as a tool for the predictive identification of skin sensitisation hazard.
Alternatives to laboratory animals : ATLA 2005;33(1):47-62.
2005: Andre Ralph; Pinteaux Emmanuel; Kimber Ian; Rothwell Nancy J
Differential actions of IL-1 alpha and IL-1 beta in glial cells share common IL-1 signalling pathways.
Neuroreport 2005;16(2):153-7.
2005: Dearman R J; Skinner R A; Deakin N; Shaw D; Kimber I
Evaluation of an in vitro method for the measurement of specific IgE antibody responses: the rat basophilic leukemia (RBL) cell assay.
Toxicology 2005;206(2):195-205.
2004: Moggs Jonathan G; Tinwell Helen; Spurway Tracey; Chang Hur-Song; Pate Ian; Lim Fei Ling; Moore David J; Soames Anthony; Stuckey Ruth; Currie Richard; Zhu Tong; Kimber Ian; Ashby John; Orphanides George
Phenotypic anchoring of gene expression changes during estrogen-induced uterine growth.
Environmental health perspectives 2004;112(16):1589-606.
2004: Betts Catherine J; Flanagan Brian F; Caddick Helen T; Dearman Rebecca J; Kimber Ian
Intradermal exposure of BALB/c strain mice to peanut protein elicits a type 2 cytokine response.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2004;42(10):1589-99.
2004: Moggs Jonathan G; Ashby John; Tinwell Helen; Lim Fei Ling; Moore David J; Kimber Ian; Orphanides George
The need to decide if all estrogens are intrinsically similar.
Environmental health perspectives 2004;112(11):1137-42.
2004: Dearman Rebecca J; Bhushan Monica; Cumberbatch Marie; Kimber Ian; Griffiths Christopher E M
Measurement of cytokine expression and Langerhans cell migration in human skin following suction blister formation.
Experimental dermatology 2004;13(7):452-60.
2004: Gerberick G Frank; Ryan Cindy A; Kern Petra S; Dearman Rebecca J; Kimber Ian; Patlewicz Grace Y; Basketter David A
A chemical dataset for evaluation of alternative approaches to skin-sensitization testing.
Contact dermatitis 2004;50(5):274-88.
2004: Ryan Cindy A; Gildea Lucy A; Hulette Ben C; Dearman Rebecca J; Kimber Ian; Gerberick G Frank
Gene expression changes in peripheral blood-derived dendritic cells following exposure to a contact allergen.
Toxicology letters 2004;150(3):301-16.
2004: Kimber I; Cumberbatch M; Betts C J; Dearman R J
Dendritic cells and skin sensitisation hazard assessment.
Toxicology in vitro : an international journal published in association with BIBRA 2004;18(2):195-202.
2003: Dearman Rebecca J; Kimber Ian
Factors influencing the induction phase of skin sensitization.
American journal of contact dermatitis : official journal of the American Contact Dermatitis Society 2003;14(4):188-94.
2003: Andre Ralph; Wheeler Rachel D; Collins Peter D; Luheshi Giamal N; Pickering-Brown Stuart; Kimber Ian; Rothwell Nancy J; Pinteaux Emmanuel
Identification of a truncated IL-18R beta mRNA: a putative regulator of IL-18 expressed in rat brain.
Journal of neuroimmunology 2003;145(1-2):40-5.
2003: Kimber I; Basketter D A; Butler M; Gamer A; Garrigue J-L; Gerberick G F; Newsome C; Steiling W; Vohr H-W
Classification of contact allergens according to potency: proposals.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(12):1799-809.
2003: Dearman R J; Stone S; Caddick H T; Basketter D A; Kimber I
Evaluation of protein allergenic potential in mice: dose-response analyses.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2003;33(11):1586-94.
2003: Dearman R J; Skinner R A; Herouet C; Labay K; Debruyne E; Kimber I
Induction of IgE antibody responses by protein allergens: inter-laboratory comparisons.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(11):1509-16.
2003: Orphanides George; Kimber Ian
Toxicogenetics: applications and opportunities.
Toxicological sciences : an official journal of the Society of Toxicology 2003;75(1):1-6.
2003: Kimber I; Dearman R J; Gerberick G F; Roggeband R; Basketter D A
Designation of substances as skin sensitizing chemicals: a commentary.
Human & experimental toxicology 2003;22(8):439-43.
2003: Cumberbatch Marie; Dearman Rebecca J; Griffiths Christopher E M; Kimber Ian
Epidermal Langerhans cell migration and sensitisation to chemical allergens.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2003;111(7-8):797-804.
2003: Dearman R J; Skinner R A; Humphreys N E; Kimber I
Methods for the identification of chemical respiratory allergens in rodents: comparisons of cytokine profiling with induced changes in serum IgE.
Journal of applied toxicology : JAT 2003;23(4):199-207.
2003: Warbrick E V; Kilgour J D; Dearman R J; Kimber I; Dugard P H
Inhalation exposure to methylene chloride does not induce systemic immunotoxicity in rats.
Journal of toxicology and environmental health. Part A 2003;66(13):1207-19.
2003: Boutin Herve; Kimber Ian; Rothwell Nancy J; Pinteaux Emmanuel
The expanding interleukin-1 family and its receptors: do alternative IL-1 receptor/signaling pathways exist in the brain?
Molecular neurobiology 2003;27(3):239-48.
2003: Kimber Ian; Dearman Rebecca J; Penninks Andre H; Knippels Leon M J; Buchanan Robert B; Hammerberg Bruce; Jackson Hilary A; Helm Ricki M
Assessment of protein allergenicity on the basis of immune reactivity: animal models.
Environmental health perspectives 2003;111(8):1125-30.
2003: Kimber Ian; Dearman Rebecca J
What makes a chemical an allergen?
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2003;90(5 Suppl 2):28-31.
2003: Humphreys Neil E; Dearman Rebecca J; Kimber Ian
Assessment of cumulative allergen-activated lymph node cell proliferation using flow cytometry.
Toxicological sciences : an official journal of the Society of Toxicology 2003;73(1):80-9.
2003: Cumberbatch M; Bhushan M; Dearman R J; Kimber I; Griffiths C E M
IL-1beta-induced Langerhans' cell migration and TNF-alpha production in human skin: regulation by lactoferrin.
Clinical and experimental immunology 2003;132(2):352-9.
2003: Kimber Ian; Betts Catherine J; Dearman Rebecca J
Assessment of the allergenic potential of proteins.
Toxicology letters 2003;140-141():297-302.
2003: Betts Catherine J; Moggs Jonathan G; Caddick Helen T; Cumberbatch Marie; Orphanides George; Dearman Rebecca J; Ryan Cindy A; Hulette Ben C; Frank Gerberick G; Kimber Ian
Assessment of glycosylation-dependent cell adhesion molecule 1 as a correlate of allergen-stimulated lymph node activation.
Toxicology 2003;185(1-2):103-17.
2003: Kimber Ian; Stone Sue; Dearman Rebecca J
Assessment of the inherent allergenic potential of proteins in mice.
Environmental health perspectives 2003;111(2):227-31.
2003: Dearman Rebecca J; Betts Catherine J; Humphreys Neil; Flanagan Brian F; Gilmour Nicola J; Basketter David A; Kimber Ian
Chemical allergy: considerations for the practical application of cytokine profiling.
Toxicological sciences : an official journal of the Society of Toxicology 2003;71(2):137-45.
2002: Kimber Ian; Dearman R J; Basketter D A; Ryan C A; Gerberick G F
The local lymph node assay: past, present and future.
Contact dermatitis 2002;47(6):315-28.
2002: Kimber Ian; Dearman Rebecca J
Chemical respiratory allergy: role of IgE antibody and relevance of route of exposure.
Toxicology 2002;181-182():311-5.
2002: Betts Catherine J; Dearman Rebecca J; Flanagan Brian F; Kimber Ian
Temporal changes in cytokine gene expression profiles induced in mice by trimellitic anhydride.
Toxicology letters 2002;136(2):121-32.
2002: Dearman R J; Warbrick E V; Skinner R; Kimber I
Cytokine fingerprinting of chemical allergens: species comparisons and statistical analyses.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2002;40(12):1881-92.
2002: Kimber Ian; Dearman Rebecca J
Factors affecting the development of food allergy.
The Proceedings of the Nutrition Society 2002;61(4):435-9.
2002: Kimber Ian
Reduction, refinement and replacement: putting the immune system to work.
Alternatives to laboratory animals : ATLA 2002;30(6):569-77.
2002: Ryan C A; Cruse L W; Skinner R A; Dearman R J; Kimber I; Gerberick G F
Examination of a vehicle for use with water soluble materials in the murine local lymph node assay.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2002;40(11):1719-25.
2002: Dearman Rebecca J; Filby Andrew; Humphreys Ian R; Kimber Ian
Interleukins 5 and 13 characterize immune responses to respiratory sensitizing acid anhydrides.
Journal of applied toxicology : JAT 2002;22(5):317-25.
2002: Gerberick G Frank; Cruse Lynn W; Ryan Cindy A; Hulette Ben C; Chaney Joel G; Skinner Robert A; Dearman Rebecca J; Kimber Ian
Use of a B cell marker (B220) to discriminate between allergens and irritants in the local lymph node assay.
Toxicological sciences : an official journal of the Society of Toxicology 2002;68(2):420-8.
2002: Hasmall Susan; Orphanides George; James Neil; Pennie William; Hedley Kathryn; Soames Anthony; Kimber Ian; Roberts Ruth
Downregulation of lactoferrin by PPARalpha ligands: role in perturbation of hepatocyte proliferation and apoptosis.
Toxicological sciences : an official journal of the Society of Toxicology 2002;68(2):304-13.
2002: Cumberbatch Marie; Dearman Rebecca J; Groves Richard W; Antonopoulos Christos; Kimber Ian
Differential regulation of epidermal langerhans cell migration by interleukins (IL)-1alpha and IL-1beta during irritant- and allergen-induced cutaneous immune responses.
Toxicology and applied pharmacology 2002;182(2):126-35.
2002: Kimber Ian; Dearman Rebecca J
Approaches to assessment of the allergenic potential of novel proteins in food from genetically modified crops.
Toxicological sciences : an official journal of the Society of Toxicology 2002;68(1):4-8.
2002: Pennie W D; Kimber I
Toxicogenomics; transcript profiling and potential application to chemical allergy.
Toxicology in vitro : an international journal published in association with BIBRA 2002;16(3):319-26.
2002: Atherton Keith T; Dearman Rebecca J; Kimber Ian
Protein allergenicity in mice: a potential approach for hazard identification.
Annals of the New York Academy of Sciences 2002;964():163-71.
2002: Dearman R J; Caddick H; Stone S; Kenna J G; Basketter D A; Kimber I
Immunogenic properties of rapidly digested food proteins following gavage exposure of mice: a comparison of ovalbumin with a potato acid phosphatase preparation.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2002;40(5):625-33.
2002: Cumberbatch Marie; Dearman Rebecca J; Kimber Ian
Influence of ageing on Langerhans cell migration in mice: identification of a putative deficiency of epidermal interleukin-1beta.
Immunology 2002;105(4):466-77.
2002: Elcombe Clifford R; Odum Jenny; Foster John R; Stone Susan; Hasmall Susan; Soames Anthony R; Kimber Ian; Ashby John
Prediction of rodent nongenotoxic carcinogenesis: evaluation of biochemical and tissue changes in rodents following exposure to nine nongenotoxic NTP carcinogens.
Environmental health perspectives 2002;110(4):363-75.
2002: Warbrick E Vicky; Dearman Rebecca J; Kimber Ian
IgG and IgE antibody responses following exposure of Brown Norway rats to trimellitic anhydride: comparison of inhalation and topical exposure.
Toxicology 2002;172(3):157-68.
2002: Kimber Ian; Dearman Rebecca J
Immunologic basis for autoimmunity and the potential influences of xenobiotics.
Toxicology letters 2002;127(1-3):77-81.
2002: Kimber Ian; Basketter David A; Gerberick G Frank; Dearman Rebecca J
Allergic contact dermatitis.
International immunopharmacology 2002;2(2-3):201-11.
2002: Kimber Ian; Dearman Rebecca J
Allergic contact dermatitis: the cellular effectors.
Contact dermatitis 2002;46(1):1-5.
2002: Kimber Ian; Dearman Rebecca J
Immune responses: adverse versus non-adverse effects.
Toxicologic pathology 2002;30(1):54-8.
2002: Bhushan M; Cumberbatch M; Dearman R J; Andrew S M; Kimber I; Griffiths C E M
Tumour necrosis factor-alpha-induced migration of human Langerhans cells: the influence of ageing.
The British journal of dermatology 2002;146(1):32-40.
2002: Warbrick E V; Dearman R J; Kimber I
Induced changes in total serum IgE concentration in the Brown Norway rat: potential for identification of chemical respiratory allergens.
Journal of applied toxicology : JAT 2002;22(1):1-11.
2002: Kimber I; Cumberbatch M; Dearman R J; Headon D R; Bhushan M; Griffiths C E M
Lactoferrin: influences on Langerhans cells, epidermal cytokines, and cutaneous inflammation.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2002;80(1):103-7.
2001: Kimber I; Basketter D A; Roggeband R
Chemical respiratory allergy: classification and labelling.
Toxicology 2001;167(2):159-62.
2001: Dearman R J; Caddick H; Stone S; Basketter D A; Kimber I
Characterization of antibody responses induced in rodents by exposure to food proteins: influence of route of exposure.
Toxicology 2001;167(3):217-31.
2001: Craighead M W; Middlehurst K M; LeFeuvre R; Kimber I; Rothwell N J
Oxidised adenosine 5'-triphosphate, a P2X(7) antagonist, is toxic to rat cerebellar granule neurones in vitro.
Neuroscience letters 2001;311(2):77-80.
2001: Gerberick G F; Robinson M K; Ryan C A; Dearman R J; Kimber I; Basketter D A; Wright Z; Marks J G
Contact allergenic potency: correlation of human and local lymph node assay data.
American journal of contact dermatitis : official journal of the American Contact Dermatitis Society 2001;12(3):156-61.
2001: Kimber I; Pichowski J S; Betts C J; Cumberbatch M; Basketter D A; Dearman R J
Alternative approaches to the identification and characterization of chemical allergens.
Toxicology in vitro : an international journal published in association with BIBRA 2001;15(4-5):307-12.
2001: Basketter D A; Wright Z M; Warbrick E V; Dearman R J; Kimber I; Ryan C A; Gerberick G F; White I R
Human potency predictions for aldehydes using the local lymph node assay.
Contact dermatitis 2001;45(2):89-94.
2001: Basketter D A; Gerberick G F; Kimber I
Measurement of allergenic potency using the local lymph node assay.
Trends in pharmacological sciences 2001;22(6):264-5.
2001: Dearman R J; Wright Z M; Basketter D A; Ryan C A; Gerberick G F; Kimber I
The suitability of hexyl cinnamic aldehyde as a calibrant for the murine local lymph node assay.
Contact dermatitis 2001;44(6):357-61.
2001: Basketter D A; Gerberick G F; Kimber I
Skin sensitisation, vehicle effects and the local lymph node assay.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2001;39(6):621-7.
2001: Warbrick E V; Dearman R J; Ashby J; Schmezer P; Kimber I
Preliminary assessment of the skin sensitizing activity of selected rodent carcinogens using the local lymph node assay.
Toxicology 2001;163(1):63-9.
2001: Wright Z M; Basketter P A; Blaikie L; Cooper K J; Warbrick E V; Dearman R J; Kimber I
Vehicle effects on skin sensitizing potency of four chemicals: assessment using the local lymph node assay.
International journal of cosmetic science 2001;23(2):75-83.
2001: Griffiths C E; Cumberbatch M; Tucker S C; Dearman R J; Andrew S; Headon D R; Kimber I
Exogenous topical lactoferrin inhibits allergen-induced Langerhans cell migration and cutaneous inflammation in humans.
The British journal of dermatology 2001;144(4):715-25.
2001: Steiling W; Basketter D; Berthold K; Butler M; Garrigue J L; Kimber I; Lea L; Newsome C; Roggeband R; Stropp G; Waterman S; Wiemann C
Skin sensitisation testing--new perspectives and recommendations.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2001;39(4):293-301.
2001: Dearman R J; Kimber I
Determination of protein allergenicity: studies in mice.
Toxicology letters 2001;120(1-3):181-6.
2001: Kimber I; Dearman R J
Food allergy: what are the issues?
Toxicology letters 2001;120(1-3):165-70.
2001: Cumberbatch M; Dearman R J; Antonopoulos C; Groves R W; Kimber I
Interleukin (IL)-18 induces Langerhans cell migration by a tumour necrosis factor-alpha- and IL-1beta-dependent mechanism.
Immunology 2001;102(3):323-30.
2001: Dearman R J; Kimber I
Cytokine fingerprinting and hazard assessment of chemical respiratory allergy.
Journal of applied toxicology : JAT 2001;21(2):153-63.
2001: Pichowski J S; Cumberbatch M; Dearman R J; Basketter D A; Kimber I
Allergen-induced changes in interleukin 1 beta (IL-1 beta) mRNA expression by human blood-derived dendritic cells: inter-individual differences and relevance for sensitization testing.
Journal of applied toxicology : JAT 2001;21(2):115-21.
2001: Antonopoulos C; Cumberbatch M; Dearman R J; Daniel R J; Kimber I; Groves R W
Functional caspase-1 is required for Langerhans cell migration and optimal contact sensitization in mice.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(6):3672-7.
2001: Kimber I
The local lymph node assay and potential application to the identification of drug allergens.
Toxicology 2001;158(1-2):59-64.
2001: Kimber I; Basketter D A; Berthold K; Butler M; Garrigue J L; Lea L; Newsome C; Roggeband R; Steiling W; Stropp G; Waterman S; Wiemann C
Skin sensitization testing in potency and risk assessment.
Toxicological sciences : an official journal of the Society of Toxicology 2001;59(2):198-208.
2001: Warbrick E V; Dearman R J; Kimber I
Prediction of drug allergenicity: possible use of the local lymph node assay.
Current opinion in drug discovery & development 2001;4(1):60-5.
2000: Dearman R J; Kimber I
Role of CD4(+) T helper 2-type cells in cutaneous inflammatory responses induced by fluorescein isothiocyanate.
Immunology 2000;101(4):442-51.
2000: Craighead M W; Boutin H; Middlehurst K M; Allan S M; Brooks N; Kimber I; Rothwell N J
Influence of corticotrophin releasing factor on neuronal cell death in vitro and in vivo.
Brain research 2000;881(2):139-43.
2000: Ashby J; Tinwell H; Odum J; Kimber I; Brooks A N; Pate I; Boyle C C
Diet and the aetiology of temporal advances in human and rodent sexual development.
Journal of applied toxicology : JAT 2000;20(5):343-7.
2000: Ryan C A; Gerberick G F; Cruse L W; Basketter D A; Lea L; Blaikie L; Dearman R J; Warbrick E V; Kimber I
Activity of human contact allergens in the murine local lymph node assay.
Contact dermatitis 2000;43(2):95-102.
2000: Pichowski J S; Cumberbatch M; Dearman; Basketter D A; Kimber I
Investigation of induced changes in interleukin 1beta mRNA expression by cultured human dendritic cells as an in vitro approach to skin sensitization testing.
Toxicology in vitro : an international journal published in association with BIBRA 2000;14(4):351-60.
2000: Cumberbatch M; Dearman R J; Griffiths C E; Kimber I
Langerhans cell migration.
Clinical and experimental dermatology 2000;25(5):413-8.
2000: Cumberbatch M; Dearman R J; Uribe-Luna S; Headon D R; Ward P P; Conneely O M; Kimber I
Regulation of epidermal Langerhans cell migration by lactoferrin.
Immunology 2000;100(1):21-8.
2000: Dearman R J; Warbrick E V; Humphreys I R; Kimber I
Characterization in mice of the immunological properties of five allergenic acid anhydrides.
Journal of applied toxicology : JAT 2000;20(3):221-30.
2000: Warbrick E V; Dearman R J; Basketter D A; Kimber I
Failure of vehicle to influence local lymph node assay response to benzocaine.
Contact dermatitis 2000;42(3):164-5.
2000: Gerberick G F; Ryan C A; Kimber I; Dearman R J; Lea L J; Basketter D A
Local lymph node assay: validation assessment for regulatory purposes.
American journal of contact dermatitis : official journal of the American Contact Dermatitis Society 2000;11(1):3-18.
2000: Holden P R; James N H; Brooks A N; Roberts R A; Kimber I; Pennie W D
Identification of a possible association between carbon tetrachloride-induced hepatotoxicity and interleukin-8 expression.
Journal of biochemical and molecular toxicology 2000;14(5):283-90.
1999: Basketter D A; Lea L J; Cooper K; Stocks J; Dickens A; Pate I; Dearman R J; Kimber I
Threshold for classification as a skin sensitizer in the local lymph node assay: a statistical evaluation.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1999;37(12):1167-74.
1999: Lea L J; Warbrick E V; Dearman R J; Kimber I; Basketter D A
The impact of vehicle on assessment of relative skin sensitization potency of 1,4-dihydroquinone in the local lymph node assay.
American journal of contact dermatitis : official journal of the American Contact Dermatitis Society 1999;10(4):213-8.
1999: Basketter D A; Lea L J; Cooper K J; Ryan C A; Gerberick G F; Dearman R J; Kimber I
Identification of metal allergens in the local lymph node assay.
American journal of contact dermatitis : official journal of the American Contact Dermatitis Society 1999;10(4):207-12.
1999: Cumberbatch M; Griffiths C E; Tucker S C; Dearman R J; Kimber I
Tumour necrosis factor-alpha induces Langerhans cell migration in humans.
The British journal of dermatology 1999;141(2):192-200.
1999: Basketter D A; Lea L J; Dickens A; Briggs D; Pate I; Dearman R J; Kimber I
A comparison of statistical approaches to the derivation of EC3 values from local lymph node assay dose responses.
Journal of applied toxicology : JAT 1999;19(4):261-6.
1999: Warbrick E V; Dearman R J; Lea L J; Basketter D A; Kimber I
Local lymph node assay responses to paraphenylenediamine: intra- and inter-laboratory evaluations.
Journal of applied toxicology : JAT 1999;19(4):255-60.
1999: Cumberbatch M; Dearman R J; Kimber I
Langerhans cell migration in mice requires intact type I interleukin 1 receptor (IL-1RI) function.
Archives of dermatological research 1999;291(6):357-61.
1999: Kimber I; Pichowski J S; Basketter D A; Dearman R J
Immune responses to contact allergens: novel approaches to hazard evaluation.
Toxicology letters 1999;106(2-3):237-46.
1999: Kimber I; Gerberick G F; Basketter D A
Thresholds in contact sensitization: theoretical and practical considerations.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1999;37(5):553-60.
1999: Dearman R J; Hilton J; Basketter D A; Kimber I
Cytokine endpoints for the local lymph node assay: consideration of interferon-gamma and interleukin 12.
Journal of applied toxicology : JAT 1999;19(3):149-55.
1999: Cumberbatch M; Dearman R J; Kimber I
Inhibition by dexamethasone of Langerhans cell migration: influence of epidermal cytokine signals.
Immunopharmacology 1999;41(3):235-43.
1999: Kimber I; Kerkvliet N I; Taylor S L; Astwood J D; Sarlo K; Dearman R J
Toxicology of protein allergenicity: prediction and characterization.
Toxicological sciences : an official journal of the Society of Toxicology 1999;48(2):157-62.
1999: Basketter D A; Rodford R; Kimber I; Smith I; Wahlberg J E
Skin sensitization risk assessment: a comparative evaluation of 3 isothiazolinone biocides.
Contact dermatitis 1999;40(3):150-4.
1999: Warbrick E V; Dearman R J; Basketter D A; Kimber I
Analysis of interleukin 12 protein production and mRNA expression in mice exposed topically to chemical allergens.
Toxicology 1999;132(1):57-66.
1999: Dearman R J; Basketter D A; Evans P; Kimber I
Comparison of cytokine secretion profiles provoked in mice by glutaraldehyde and formaldehyde.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1999;29(1):124-32.
1998: Kimber I
Allergy, asthma and the environment: an introduction.
Toxicology letters 1998;102-103():301-6.
1998: Cumberbatch M; Dearman R J; Kimber I
Characteristics and regulation of the expression on interleukin 1 receptors by murine Langerhans cells and keratinocytes.
Archives of dermatological research 1998;290(12):688-95.
1998: Kimber I; Warbrick E V; Dearman R J
Chemical respiratory allergy, IgE and the relevance of predictive test methods: a commentary.
Human & experimental toxicology 1998;17(10):537-40.
1998: Dearman R J; Hilton J; Evans P; Harvey P; Basketter D A; Kimber I
Temporal stability of local lymph node assay responses to hexyl cinnamic aldehyde.
Journal of applied toxicology : JAT 1998;18(4):281-4.
1998: Warbrick E V; Dearman R J; Basketter D A; Gerberick G F; Ryan C A; Kimber I
Analysis of cytokine mRNA expression following repeated exposure of mice to chemical contact and respiratory allergens.
Journal of applied toxicology : JAT 1998;18(3):205-13.
1998: Kimber I; Hilton J; Dearman R J; Gerberick G F; Ryan C A; Basketter D A; Lea L; House R V; Ladics G S; Loveless S E; Hastings K L
Assessment of the skin sensitization potential of topical medicaments using the local lymph node assay: an interlaboratory evaluation.
Journal of toxicology and environmental health. Part A 1998;53(7):563-79.
1998: Dearman R J; Basketter D A; Kimber I
Selective induction of type 2 cytokines following topical exposure of mice to platinum salts.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1998;36(3):199-207.
1998: Hilton J; Dearman R J; Harvey P; Evans P; Basketter D A; Kimber I
Estimation of relative skin sensitizing potency using the local lymph node assay: a comparison of formaldehyde with glutaraldehyde.
American journal of contact dermatitis : official journal of the American Contact Dermatitis Society 1998;9(1):29-33.
1998: Kimber I; Cumberbatch M; Dearman R J; Ward P; Headon D R; Conneely O M
Regulation by lactoferrin of epidermal Langerhans cell migration.
Advances in experimental medicine and biology 1998;443():251-5.
1998: Kimber I
Regulatory immunotoxicology--the scientist's point of view: an introduction.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1998;20():271-4.
1997: Hilton J; Dearman R J; Sattar N; Basketter D A; Kimber I
Characteristics of antibody responses induced in mice by protein allergens.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1997;35(12):1209-18.
1997: Cumberbatch M; Dearman R J; Kimber I
Langerhans cells require signals from both tumour necrosis factor-alpha and interleukin-1 beta for migration.
Immunology 1997;92(3):388-95.
1997: Kimber I; Lumley C E; Metcalfe D D
Allergenicity of proteins.
Human & experimental toxicology 1997;16(9):516-8.
1997: Holliday M R; Corsini E; Smith S; Basketter D A; Dearman R J; Kimber I
Differential induction of cutaneous TNF-alpha and IL-6 by topically applied chemicals.
American journal of contact dermatitis : official journal of the American Contact Dermatitis Society 1997;8(3):158-64.
1997: Cumberbatch M; Dearman R J; Kimber I
Interleukin 1 beta and the stimulation of Langerhans cell migration: comparisons with tumour necrosis factor alpha.
Archives of dermatological research 1997;289(5):277-84.
1997: Dearman R J; Cumberbatch M; Hilton J; Fielding I; Basketter D A; Kimber I
A re-appraisal of the skin-sensitizing activity of 2,4-dinitrothiocyanobenzene.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1997;35(2):261-9.
1997: Dearman R J; Smith S; Basketter D A; Kimber I
Classification of chemical allergens according to cytokine secretion profiles of murine lymph node cells.
Journal of applied toxicology : JAT 1997;17(1):53-62.
1997: Kimber I; Dearman R J
Cell and molecular biology of chemical allergy.
Clinical reviews in allergy & immunology 1997;15(2):145-68.
1997: Cumberbatch M; Dearman R J; Kimber I
Langerhans cells require signals from both tumour necrosis factor alpha and interleukin 1 beta for migration.
Advances in experimental medicine and biology 1997;417():125-8.
1997: Cumberbatch M; Dearman R J; Kimber I
Stimulation of Langerhans cell migration in mice by tumour necrosis factor alpha and interleukin 1 beta.
Advances in experimental medicine and biology 1997;417():121-4.
1997: Kimber I; Dearman R J; Cumberbatch M
Epidermal cytokines and the induction of allergic and non-allergic contact dermatitis.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1997;19():229-38.
1996: Dearman R J; Moussavi A; Kemeny D M; Kimber I
Contribution of CD4+ and CD8+ T lymphocyte subsets to the cytokine secretion patterns induced in mice during sensitization to contact and respiratory chemical allergens.
Immunology 1996;89(4):502-10.
1996: Cumberbatch M; Dearman R J; Kimber I
Adhesion molecule expression by epidermal Langerhans cells and lymph node dendritic cells: a comparison.
Archives of dermatological research 1996;288(12):739-44.
1996: Basketter D A; Gerberick G F; Kimber I; Loveless S E
The local lymph node assay: a viable alternative to currently accepted skin sensitization tests.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1996;34(10):985-97.
1996: Vento K L; Dearman R J; Kimber I; Basketter D A; Coleman J W
Selectivity of IgE responses, mast cell sensitization, and cytokine expression in the immune response of Brown Norway rats to chemical allergens.
Cellular immunology 1996;172(2):246-53.
1996: Basketter D A; Kimber I
Olive oil: suitability for use as a vehicle in the local lymph node assay.
Contact dermatitis 1996;35(3):190-1.
1996: Hilton I; Dearman R J; Fielding I; Basketter D A; Kimber I
Evaluation of the sensitizing potential of eugenol and isoeugenol in mice and guinea pigs.
Journal of applied toxicology : JAT 1996;16(5):459-64.
1996: Dearman R J; Cumberbatch M; Hilton J; Clowes H M; Fielding I; Heylings J R; Kimber I
Influence of dibutyl phthalate on dermal sensitization to fluorescein isothiocyanate.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1996;33(1):24-30.
1996: Kimber I; Bernstein I L; Karol M H; Robinson M K; Sarlo K; Selgrade M K
Workshop overview. Identification of respiratory allergens.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1996;33(1):1-10.
1996: Kimber I
The role of the skin in the development of chemical respiratory hypersensitivity.
Toxicology letters 1996;86(2-3):89-92.
1996: Kimber I; Hilton J; Basketter D A; Dearman R J
Predictive testing for respiratory sensitization in the mouse.
Toxicology letters 1996;86(2-3):193-8.
1996: Hilton J; Dearman R J; Basketter D A; Scholes E W; Kimber I
Experimental assessment of the sensitizing properties of formaldehyde.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1996;34(6):571-8.
1996: Dearman R J; Basketter D A; Kimber I
Characterization of chemical allergens as a function of divergent cytokine secretion profiles induced in mice.
Toxicology and applied pharmacology 1996;138(2):308-16.
1996: Heylings J R; Clowes H M; Cumberbatch M; Dearman R J; Fielding I; Hilton J; Kimber I
Sensitization to 2,4-dinitrochlorobenzene: influence of vehicle on absorption and lymph node activation.
Toxicology 1996;109(1):57-65.
1996: Dearman R J; Hope J C; Hopkins S J; Kimber I
Antigen-induced unresponsiveness in contact sensitivity: association of depressed T lymphocyte proliferative responses with decreased interleukin 6 secretion.
Immunology letters 1996;50(1-2):29-34.
1996: Cumberbatch M; Dearman R J; Kimber I
Constitutive and inducible expression of interleukin-6 by Langerhans cells and lymph node dendritic cells.
Immunology 1996;87(4):513-8.
1996: Loveless S E; Ladics G S; Gerberick G F; Ryan C A; Basketter D A; Scholes E W; House R V; Hilton J; Dearman R J; Kimber I
Further evaluation of the local lymph node assay in the final phase of an international collaborative trial.
Toxicology 1996;108(1-2):141-52.
1996: Hilton J; Dearman R J; Boylett M S; Fielding I; Basketter D A; Kimber I
The mouse IgE test for the identification of potential chemical respiratory allergens: considerations of stability and controls.
Journal of applied toxicology : JAT 1996;16(2):165-70.
1996: Holliday M R; Dearman R J; Corsini E; Basketter D A; Kimber I
Selective stimulation of cutaneous interleukin 6 expression by skin allergens.
Journal of applied toxicology : JAT 1996;16(1):65-70.
1996: Basketter D A; Scholes E W; Fielding I; Dearman R J; Hilton J; Kimber I
Dichloronitrobenzene: a reappraisal of its skin sensitization potential.
Contact dermatitis 1996;34(1):55-8.
1996: Holliday M R; Dearman R J; Basketter D A; Kimber I
Stimulation by oxazolone of increased IL-6, but not IL-10, in the skin of mice.
Toxicology 1996;106(1-3):237-42.
1996: Kimber I
Impact of environmental pollution on respiratory sensitization and asthma.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1996;18():34-48.
1995: Kimber I; Holliday M R; Dearman R J
Cytokine regulation of chemical sensitization.
Toxicology letters 1995;82-83():491-6.
1995: Dearman R J; Basketter D A; Kimber I
Differential cytokine production following chronic exposure of mice to chemical respiratory and contact allergens.
Immunology 1995;86(4):545-50.
1995: Ashby J; Basketter D A; Paton D; Kimber I
Structure activity relationships in skin sensitization using the murine local lymph node assay.
Toxicology 1995;103(3):177-94.
1995: Hope J C; Cumberbatch M; Fielding I; Dearman R J; Kimber I; Hopkins S J
Identification of dendritic cells as a major source of interleukin-6 in draining lymph nodes following skin sensitization of mice.
Immunology 1995;86(3):441-7.
1995: Kimber I; Hilton J; Dearman R J; Gerberick G F; Ryan C A; Basketter D A; Scholes E W; Ladics G S; Loveless S E; House R V
An international evaluation of the murine local lymph node assay and comparison of modified procedures.
Toxicology 1995;103(1):63-73.
1995: Kimber I; Wilks M F
Chemical respiratory allergy. Toxicological and occupational health issues.
Human & experimental toxicology 1995;14(9):735-6.
1995: Ashby J; Hilton J; Dearman R J; Kimber I
Streptozotocin: inherent but not expressed skin sensitizing activity.
Contact dermatitis 1995;33(3):165-7.
1995: Cumberbatch M; Kimber I
Tumour necrosis factor-alpha is required for accumulation of dendritic cells in draining lymph nodes and for optimal contact sensitization.
Immunology 1995;84(1):31-5.
1995: Kimber I
Biomarkers of immunotoxicity in man.
Human & experimental toxicology 1995;14(1):148-9.
1995: Cumberbatch M; Hope J C; Dearman R J; Hopkins S J; Kimber I
Migration of interleukin-6 producing Langerhans cells to draining lymph nodes following skin sensitization.
Advances in experimental medicine and biology 1995;378():531-3.
1995: Cumberbatch M; Fielding I; Kimber I
Epidermal Langerhans cell migration: signals and mechanisms.
Advances in experimental medicine and biology 1995;378():173-5.
1994: Hope J C; Dearman R J; Kimber I; Hopkins S J
The kinetics of cytokine production by draining lymph node cells following primary exposure of mice to chemical allergens.
Immunology 1994;83(2):250-5.
1994: Kimber I; Dearman R J; Scholes E W; Basketter D A
The local lymph node assay: developments and applications.
Toxicology 1994;93(1):13-31.
1994: Kimber I
Cytokines and regulation of allergic sensitization to chemicals.
Toxicology 1994;93(1):1-11.
1994: Dearman R J; Scholes E W; Ramdin L S; Basketter D A; Kimber I
The local lymph node assay: an interlaboratory evaluation of interleukin 6 (IL-6) production by draining lymph node cells.
Journal of applied toxicology : JAT 1994;14(4):287-91.
1994: Hilton J; Dearman R J; Basketter D A; Kimber I
Serological responses induced in mice by immunogenic proteins and by protein respiratory allergens.
Toxicology letters 1994;73(1):43-53.
1994: Basketter D A; Scholes E W; Kimber I
The performance of the local lymph node assay with chemicals identified as contact allergens in the human maximization test.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1994;32(6):543-7.
1994: Holliday M R; Banks E M; Dearman R J; Kimber I; Coleman J W
Interactions of IFN-gamma with IL-3 and IL-4 in the regulation of serotonin and arachidonate release from mouse peritoneal mast cells.
Immunology 1994;82(1):70-4.
1994: Dearman R J; Ramdin L S; Basketter D A; Kimber I
Inducible interleukin-4-secreting cells provoked in mice during chemical sensitization.
Immunology 1994;81(4):551-7.
1994: Coleman J W; Holliday M R; Dearman R J; Kimber I
Cytokine-mast cell interactions: relevance to IgE-mediated chemical allergy.
Toxicology 1994;88(1-3):225-35.
1994: Rattray N J; Botham P A; Hext P M; Woodcock D R; Fielding I; Dearman R J; Kimber I
Induction of respiratory hypersensitivity to diphenylmethane-4,4'-diisocyanate (MDI) in guinea pigs. Influence of route of exposure.
Toxicology 1994;88(1-3):15-30.
1994: Cumberbatch M; Fielding I; Kimber I
Modulation of epidermal Langerhans' cell frequency by tumour necrosis factor-alpha.
Immunology 1994;81(3):395-401.
1994: Hope J C; Dearman R J; Debicki R J; Kimber I; Hopkins S J
Interleukin-6 production by draining lymph node cells following primary contact sensitisation of mice: relationship to the proliferative response.
International archives of allergy and immunology 1994;103(4):378-83.
1993: Ashby J; Hilton J; Dearman R J; Callander R D; Kimber I
Mechanistic relationship among mutagenicity, skin sensitization, and skin carcinogenicity.
Environmental health perspectives 1993;101(1):62-7.
1993: Holliday M R; Coleman J W; Dearman R J; Kimber I
Induction of mast cell sensitization by chemical allergens: a comparative study.
Journal of applied toxicology : JAT 1993;13(2):137-42.
1993: Holliday M R; Dearman R J; Kimber I; Coleman J W
Sensitization of mice to chemical allergens modulates the responsiveness of isolated mast cells to IgE-dependent activation.
Immunology 1993;78(3):508-10.
1993: Basketter D A; Selbie E; Scholes E W; Lees D; Kimber I; Botham P A
Results with OECD recommended positive control sensitizers in the maximization, Buehler and local lymph node assays.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1993;31(1):63-7.
1993: Cumberbatch M; Scott R C; Basketter D A; Scholes E W; Hilton J; Dearman R J; Kimber I
Influence of sodium lauryl sulphate on 2,4-dinitrochlorobenzene-induced lymph node activation.
Toxicology 1993;77(1-2):181-91.
1993: Coleman J W; Holliday M R; Kimber I; Zsebo K M; Galli S J
Regulation of mouse peritoneal mast cell secretory function by stem cell factor, IL-3 or IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(2):556-62.
1992: Kimber I; Dearman R J
The mechanisms and evaluation of chemically induced allergy.
Toxicology letters 1992;64-65 Spec No():79-84.
1992: Kimber I; Cumberbatch M
Dendritic cells and cutaneous immune responses to chemical allergens.
Toxicology and applied pharmacology 1992;117(2):137-46.
1992: Kimber I; Cumberbatch M
Stimulation of Langerhans cell migration by tumor necrosis factor alpha (TNF-alpha).
The Journal of investigative dermatology 1992;99(5):48S-50S.
1992: Cumberbatch M; Gould S J; Peters S W; Basketter D A; Dearman R J; Kimber I
Langerhans cells, antigen presentation, and the diversity of responses to chemical allergens.
The Journal of investigative dermatology 1992;99(5):107S-108S.
1992: Kimber I; Gerberick G F; Van Loveren H; House R V
Chemical allergy: molecular mechanisms and practical applications.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1992;19(4):479-83.
1992: Basketter D A; Scholes E W; Cumberbatch M; Evans C D; Kimber I
Sulphanilic acid: divergent results in the guinea pig maximization test and the local lymph node assay.
Contact dermatitis 1992;27(4):209-13.
1992: Dearman R J; Basketter D A; Kimber I
Variable effects of chemical allergens on serum IgE concentration in mice. Preliminary evaluation of a novel approach to the identification of respiratory sensitizers.
Journal of applied toxicology : JAT 1992;12(5):317-23.
1992: Dearman R J; Basketter D A; Coleman J W; Kimber I
The cellular and molecular basis for divergent allergic responses to chemicals.
Chemico-biological interactions 1992;84(1):1-10.
1992: Scholes E W; Basketter D A; Sarll A E; Kimber I; Evans C D; Miller K; Robbins M C; Harrison P T; Waite S J
The local lymph node assay: results of a final inter-laboratory validation under field conditions.
Journal of applied toxicology : JAT 1992;12(3):217-22.
1992: Cumberbatch M; Peters S W; Gould S J; Kimber I
Intercellular adhesion molecule-1 (ICAM-1) expression by lymph node dendritic cells: comparison with epidermal Langerhans cells.
Immunology letters 1992;32(2):105-10.
1992: Dearman R J; Kimber I
Divergent immune responses to respiratory and contact chemical allergens: antibody elicited by phthalic anhydride and oxazolone.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1992;22(2):241-50.
1992: Kimber I; Basketter D A
The murine local lymph node assay: a commentary on collaborative studies and new directions.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1992;30(2):165-9.
1992: Cumberbatch M; Kimber I
Dermal tumour necrosis factor-alpha induces dendritic cell migration to draining lymph nodes, and possibly provides one stimulus for Langerhans' cell migration.
Immunology 1992;75(2):257-63.
1992: Dearman R J; Spence L M; Kimber I
Characterization of murine immune responses to allergenic diisocyanates.
Toxicology and applied pharmacology 1992;112(2):190-7.
1992: Dearman R J; Mitchell J A; Basketter D A; Kimber I
Differential ability of occupational chemical contact and respiratory allergens to cause immediate and delayed dermal hypersensitivity reactions in mice.
International archives of allergy and immunology 1992;97(4):315-21.
1992: Cumberbatch M; Gould S J; Peters S W; Basketter D A; Dearman R J; Kimber I
Influence of topical exposure to chemical allergens on murine Langerhans cells. Comparison of 2,4-dinitrochlorobenzene with trimellitic anhydride.
Journal of clinical & laboratory immunology 1992;37(2):65-81.
1991: Cumberbatch M; Gould S J; Peters S W; Kimber I
MHC class II expression by Langerhans' cells and lymph node dendritic cells: possible evidence for maturation of Langerhans' cells following contact sensitization.
Immunology 1991;74(3):414-9.
1991: Kimber I
Toxicology and the immune system: a perspective.
Human & experimental toxicology 1991;10(6):445-9.
1991: Cumberbatch M; Illingworth I; Kimber I
Antigen-bearing dendritic cells in the draining lymph nodes of contact sensitized mice: cluster formation with lymphocytes.
Immunology 1991;74(1):139-45.
1991: Kimber I; Weisenberger C
Anamnestic responses to contact allergens: application in the murine local lymph node assay.
Journal of applied toxicology : JAT 1991;11(2):129-33.
1991: Dearman R J; Kimber I
Differential stimulation of immune function by respiratory and contact chemical allergens.
Immunology 1991;72(4):563-70.
1991: Kimber I; Quirke S; Cumberbatch M; Ashby J; Paton D; Aldridge R D; Hunter J A; Beck M H
Lymphocyte transformation and thiuram sensitization.
Contact dermatitis 1991;24(3):164-71.
1991: Kimber I; Dearman R J
Investigation of lymph node cell proliferation as a possible immunological correlate of contact sensitizing potential.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1991;29(2):125-9.
1991: Kimber I; Hilton J; Botham P A; Basketter D A; Scholes E W; Miller K; Robbins M C; Harrison P T; Gray T J; Waite S J
The murine local lymph node assay: results of an inter-laboratory trial.
Toxicology letters 1991;55(2):203-13.
1991: Kimber I; Foster J R; Baker D; Turk J L
Selective impairment of T lymphocyte activation following contact sensitization with oxazolone.
International archives of allergy and applied immunology 1991;95(2-3):142-8.
1991: Dearman R J; Hegarty J M; Kimber I
Inhalation exposure of mice to trimellitic anhydride induces both IgG and IgE anti-hapten antibody.
International archives of allergy and applied immunology 1991;95(1):70-6.
1990: Hopkins S J; Humphreys M; Kinnaird A; Jones D A; Kimber I
Production of interleukin-1 by draining lymph node cells during the induction phase of contact sensitization in mice.
Immunology 1990;71(4):493-6.
1990: Kimber I; Hill S; Mitchell J A; Peters S W; Knight S C
Antigenic competition in contact sensitivity. Evidence for changes in dendritic cell migration and antigen handling.
Immunology 1990;71(2):271-6.
1990: Kimber I; Hilton J; Botham P A
Identification of contact allergens using the murine local lymph node assay: comparisons with the Buehler occluded patch test in guinea pigs.
Journal of applied toxicology : JAT 1990;10(3):173-80.
1990: Kimber I; Cumberbatch M; Bentley A N; Baker D
Requirements for antigenic competition in contact sensitivity.
Journal of clinical & laboratory immunology 1990;32(2):67-72.
1990: Ashby J; Gallagher J E; Kohan M; Tinwell H; Kimber I; Paton D; Callander R D; Chouroulinkov I
1-Chloromethylpyrene: a reference skin sensitizer and genotoxin.
Mutation research 1990;243(4):281-9.
1990: Kimber I; Cumberbatch M; Humphreys M; Hopkins S J
Contact hypersensitivity induces plasma interleukin 6.
International archives of allergy and applied immunology 1990;92(1):97-9.
1990: Kimber I; Kinnaird A; Peters S W; Mitchell J A
Correlation between lymphocyte proliferative responses and dendritic cell migration in regional lymph nodes following skin painting with contact-sensitizing agents.
International archives of allergy and applied immunology 1990;93(1):47-53.
1990: Kimber I; Bentley A N; Ward R K; Baker D; Turk J L
Antigen-restricted antigenic competition induced by 2,4-dinitrochlorobenzene: association with depression of lymphocyte proliferation.
International archives of allergy and applied immunology 1990;91(3):315-22.
1989: Kimber I
Aspects of the immune response to contact allergens: opportunities for the development and modification of predictive test methods.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1989;27(11):755-62.
1989: Kinnaird A; Peters S W; Foster J R; Kimber I
Dendritic cell accumulation in draining lymph nodes during the induction phase of contact allergy in mice.
International archives of allergy and applied immunology 1989;89(2-3):202-10.
1989: Kimber I; Ward R K; Shepherd C J; Smith M N; McAdam K P; Raynes J G
Acute-phase proteins and the serological evaluation of experimental contact sensitivity in the mouse.
International archives of allergy and applied immunology 1989;89(2-3):149-55.
1986: Kimber I; Botham P A; Rattray N J; Walsh S T
Contact-sensitizing and tolerogenic properties of 2,4-dinitrothiocyanobenzene.
International archives of allergy and applied immunology 1986;81(3):258-64.

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