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Robert Kimberly

Research Profile

Chemicals & Drugs

Disorders

Lupus Erythematosus, Systemic

Genes & Molecular Sequences

Physiology

Anatomy

Neutrophils

Living Beings

Concepts & Ideas

Gene Frequency

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TOP 3
Nicholas M Pajewski; Scott D Parker; Gregory A Poland; Conrad P Quinn; Sadeep Shrestha; Jianming Tang; Howard Wiener; Brahim Aissani; Jeffrey C Edberg; Robert P Kimberly; Brett A McKinney; Richard A Kaslow
A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed.
Elizabeth A Perkins; Richard J Reynolds; S Louis Bridges; Zenoria L Causey; Jeffrey C Edberg; Yuanqing Edberg; Peter K Gregersen; Laura B Hughes; Robert P Kimberly; Dawn Landis
Association of single-nucleotide polymorphisms in CCR6, TAGAP, and TNFAIP3 with rheumatoid arthritis in African Americans.
Jun Li; Qi Wu; Pingar Yang; Matthew Bogyo; Laura E Edgington; Hui-Chen Hsu; Robert P Kimberly; Hao Li; John D Mountz
Treatment of arthritis by macrophage depletion and immunomodulation: testing an apoptosis-mediated therapy in a humanized death receptor mouse model.

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2012: Nicholas M Pajewski; Scott D Parker; Gregory A Poland; Conrad P Quinn; Sadeep Shrestha; Jianming Tang; Howard Wiener; Brahim Aissani; Jeffrey C Edberg; Robert P Kimberly; Brett A McKinney; Richard A Kaslow
A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed.
Vaccine 2012;30(32):4778-84.
2012: Elizabeth A Perkins; Richard J Reynolds; S Louis Bridges; Zenoria L Causey; Jeffrey C Edberg; Yuanqing Edberg; Peter K Gregersen; Laura B Hughes; Robert P Kimberly; Dawn Landis
Association of single-nucleotide polymorphisms in CCR6, TAGAP, and TNFAIP3 with rheumatoid arthritis in African Americans.
Arthritis and rheumatism 2012;64(5):1355-8.
2012: Jun Li; Qi Wu; Pingar Yang; Matthew Bogyo; Laura E Edgington; Hui-Chen Hsu; Robert P Kimberly; Hao Li; John D Mountz
Treatment of arthritis by macrophage depletion and immunomodulation: testing an apoptosis-mediated therapy in a humanized death receptor mouse model.
Arthritis and rheumatism 2012;64(4):1098-109.
2012: Indra Adrianto; Indrani Datta; Jessica J Hale; John B Harley; Michael C Iannuzzi; Kenneth M Kaufman; Jennifer A Kelly; Robert P Kimberly; Christopher J Lessard; Albert M Levin; Chee Paul Lin; Kathy L Moser; Ryan Parker; Benjamin A Rybicki; Adam Adler; Courtney G Montgomery
Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility.
PloS one 2012;7(8):e43907.
2011: Elena Sánchez; Betty P Tsao; Luis M Vilá; Timothy J Vyse; Graciela S Alarcón; Marta E Alarcón-Riquelme; Elizabeth E Brown; Mary E Comeau; Jeffrey C Edberg; Barry I Freedman; Patrick M Gaffney; Gary S Gilkeson; John B Harley; Chaim O Jacob; Judith A James; Diane L Kamen; Kenneth M Kaufman; Jennifer A Kelly; Robert P Kimberly; Carl D Langefeld; Joan T Merrill; Timothy B Niewold; Michelle Petri; Rosalind Ramsey-Goldman; John D Reveille; Bruce C Richardson; Amr H Sawalha
Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study.
Arthritis and rheumatism 2011;63(11):3493-501.
2011: N M Pajewski; V S Pankratz; Scott D Parker; G A Poland; W Song; J Tang; Kui Zhang; Jeffrey C Edberg; R M Jacobson; Robert P Kimberly; B A McKinney; I G Ovsyannikova; Richard A Kaslow
The role of HLA-DR-DQ haplotypes in variable antibody responses to anthrax vaccine adsorbed.
Genes and immunity 2011;12(6):457-65.
2011: Travis Hughes; Xana Kim-Howard; Jennifer A Kelly; Kenneth M Kaufman; Carl D Langefeld; Julie Ziegler; Elena Sanchez; Robert P Kimberly; Jeffrey C Edberg; Rosalind Ramsey-Goldman; Michelle Petri; John D Reveille; Javier Martín; Elizabeth E Brown; Luis M Vilá; Graciela S Alarcón; Judith A James; Gary S Gilkeson; Kathy L Moser; Patrick M Gaffney; Joan T Merrill; Timothy J Vyse; Marta E Alarcón-Riquelme; Swapan K Nath; John B Harley; Amr H Sawalha
Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21.
Arthritis and rheumatism 2011;63(6):1689-97.
2010: Laura B Hughes; Richard J Reynolds; Elizabeth E Brown; James M Kelley; Brian Thomson; Doyt L Conn; Beth L Jonas; Andrew Westfall; Miguel A Padilla; Leigh F Callahan; Edwin A Smith; Richard D Brasington; Jeffrey C Edberg; Robert P Kimberly; Larry W Moreland; Robert M Plenge; S Louis Bridges
Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans.
Arthritis and rheumatism 2010;62(12):3547-53.
2010: Xana Kim-Howard; Amit K Maiti; Juan-Manuel Anaya; Gail R Bruner; Elizabeth E Brown; Joan T Merrill; Jeffrey C Edberg; Michelle Petri; John D Reveille; Rosalind Ramsey-Goldman; Graciela S Alarcon; Timothy J Vyse; Gary S Gilkeson; Robert P Kimberly; Judith A James; Guthridge Joel; John B Harley; Swapan K Nath
ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry.
Annals of the rheumatic diseases 2010;69(7):1329-32.
2010: James M Kelley; Jeffrey C Edberg; Robert P Kimberly
Pathways: Strategies for susceptibility genes in SLE.
Autoimmunity reviews 2010;9(7):473-6.
2010: James M Kelley; Laura B Hughes; Ashima Malik; Maria I Danila; Yuanqing Edberg; Graciela S Alarcón; Doyt L Conn; Beth L Jonas; Leigh F Callahan; Edwin A Smith; Richard D Brasington; Jeffrey C Edberg; Robert P Kimberly; Larry W Moreland; S Louis Bridges
Genetic variants of STAT4 associated with rheumatoid arthritis in persons of Asian and European ancestry do not replicate in African Americans.
Annals of the rheumatic diseases 2010;69(4):625-6.
2010: James M Kelley; Jeffrey C Edberg; Robert P Kimberly
Wegener's granulomatosis: a model of auto-antibodies in mucosal autoimmunity.
Clinical immunology (Orlando, Fla.) 2010;134(2):104-12.
2009: James M Kelley; Laura B Hughes; Jeffrey D Faggard; Maria I Danila; Monica H Crawford; Yuanqing Edberg; Miguel A Padilla; Hemant K Tiwari; Andrew Westfall; Graciela S Alarcón; Doyt L Conn; Beth L Jonas; Leigh F Callahan; Edwin A Smith; Richard D Brasington; David Allison; Robert P Kimberly; Larry W Moreland; Jeffrey C Edberg; S Louis Bridges
Retraction: an African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans.
PLoS genetics 2009;5(12):.
2009: Andrew W Gibson; Fu Jun Li; Jianming Wu; Jeffrey C Edberg; Kaihong Su; John Cafardi; Howard Wiener; Hemant K Tiwari; Robert P Kimberly; Randall S Davis
The FCRL3-169CT promoter single-nucleotide polymorphism, which is associated with systemic lupus erythematosus in a Japanese population, predicts expression of receptor protein on CD19+ B cells.
Arthritis and rheumatism 2009;60(11):3510-2.
2009: Ryan Webb; Joan T Merrill; Jennifer A Kelly; Andrea Sestak; Kenneth M Kaufman; Carl D Langefeld; Julie Ziegler; Robert P Kimberly; Jeffrey C Edberg; Rosalind Ramsey-Goldman; Michelle Petri; John D Reveille; Graciela S Alarcón; Luis M Vilá; Marta E Alarcón-Riquelme; Judith A James; Gary S Gilkeson; Chaim O Jacob; Kathy L Moser; Patrick M Gaffney; Timothy J Vyse; Swapan K Nath; Peter Lipsky; John B Harley; Amr H Sawalha
A polymorphism within IL21R confers risk for systemic lupus erythematosus.
Arthritis and rheumatism 2009;60(8):2402-7.
2009: Ryan Webb; Jonathan Wren; Matlock Jeffries; Jennifer A Kelly; Kenneth M Kaufman; Yuhong Tang; Mark Barton Frank; Joan Merrill; Robert P Kimberly; Jeffrey C Edberg; Rosalind Ramsey-Goldman; Michelle Petri; John D Reveille; Graciela S Alarcón; Luis M Vilá; Marta E Alarcón-Riquelme; Judith A James; Timothy J Vyse; Kathy L Moser; Patrick M Gaffney; Gary S Gilkeson; John B Harley; Amr H Sawalha
Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus.
Arthritis and rheumatism 2009;60(4):1076-84.
2009: Shizhong Han; Xana Kim-Howard; Harshal Deshmukh; Yoichiro Kamatani; Parvathi Viswanathan; Guthridge Joel; Kenaz Thomas; Kenneth M Kaufman; Joshua Ojwang; Adriana Rojas-Villarraga; Vicente Baca; Lorena Orozco; Benjamin Rhodes; Chan-Bum Choi; Peter K Gregersen; Joan T Merrill; Judith A James; Patrick M Gaffney; Kathy L Moser; Chaim O Jacob; Robert P Kimberly; John B Harley; Sang-Cheol Bae; Juan-Manuel Anaya; Marta E Alarcón-Riquelme; Koichi Matsuda; Timothy J Vyse; Swapan K Nath
Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE).
Human molecular genetics 2009;18(6):1171-80.
2009: James M Kelley; Laura B Hughes; Jeffrey D Faggard; Maria I Danila; Monica H Crawford; Yuanqing Edberg; Miguel A Padilla; Hemant K Tiwari; Andrew Westfall; Graciela S Alarcón; Doyt L Conn; Beth L Jonas; Leigh F Callahan; Edwin A Smith; Richard D Brasington; David Allison; Robert P Kimberly; Larry W Moreland; Jeffrey C Edberg; S Louis Bridges
An African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans.
PLoS genetics 2009;5(3):e1000424.
2008: Kun Qian; Fenglong Xie; Andrew W Gibson; Jeffrey C Edberg; Robert P Kimberly; Jianming Wu
Functional expression of IgA receptor FcalphaRI on human platelets.
Journal of leukocyte biology 2008;84(6):1492-500.
2008: Sergio Durán; Mandar Apte; Graciela S Alarcón; Miranda C Marion; Jeffrey C Edberg; Robert P Kimberly; Jie Zhang; Carl D Langefeld; Luis M Vilá; John D Reveille
Features associated with, and the impact of, hemolytic anemia in patients with systemic lupus erythematosus: LX, results from a multiethnic cohort.
Arthritis and rheumatism 2008;59(9):1332-40.
2008: R Hal Scofield; Gail R Bruner; Bahram Namjou; Robert P Kimberly; Rosalind Ramsey-Goldman; Michelle Petri; John D Reveille; Graciela S Alarcón; Luis M Vilá; Jeff Reid; Bryan Harris; Shibo Li; Jennifer A Kelly; John B Harley
Klinefelter's syndrome (47,XXY) in male systemic lupus erythematosus patients: support for the notion of a gene-dose effect from the X chromosome.
Arthritis and rheumatism 2008;58(8):2511-7.
2008: Xinrui Li; Kaihong Su; Chuanyi Ji; Alexander Szalai; Jianming Wu; Yan Zhang; Tong Zhou; Robert P Kimberly; Jeffrey C Edberg
Immune opsonins modulate BLyS/BAFF release in a receptor-specific fashion.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):1012-8.
2008: Jeffrey C Edberg; Jianming Wu; Carl D Langefeld; Elizabeth E Brown; Miranda C Marion; Gerald McGwin; Michelle Petri; Rosalind Ramsey-Goldman; John D Reveille; Summer G Frank; Kenneth M Kaufman; John B Harley; Graciela S Alarcón; Robert P Kimberly
Genetic variation in the CRP promoter: association with systemic lupus erythematosus.
Human molecular genetics 2008;17(8):1147-55.
2008: Jennifer A Kelly; J M Kelley; Kenneth M Kaufman; Jeff Kilpatrick; Gail R Bruner; J T Merrill; Judith A James; S G Frank; E Reams; Elizabeth E Brown; A W Gibson; M C Marion; Carl D Langefeld; Quan-Zhen Li; D R Karp; Edward K Wakeland; Michelle Petri; R Ramsey-Goldman; J D Reveille; L M Vilá; G S Alarcón; Robert P Kimberly; John B Harley; J C Edberg
Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans.
Genes and immunity 2008;9(3):187-94.
2008: Swapan K Nath; Shizhong Han; Xana R Kim-Howard; Jennifer A Kelly; Parvathi Viswanathan; Gary S Gilkeson; Wei Chen; Cheng Zhu; Rodger P McEver; Robert P Kimberly; Marta E Alarcón-Riquelme; Timothy J Vyse; Quan-Zhen Li; Edward K Wakeland; Joan T Merrill; Judith A James; Kenneth M Kaufman; Guthridge Joel; John B Harley
A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.
Nature genetics 2008;40(2):152-4.
2008: John B Harley; Marta E Alarcón-Riquelme; Lindsey A Criswell; Chaim O Jacob; Robert P Kimberly; Kathy L Moser; Betty P Tsao; Timothy J Vyse; Carl D Langefeld; Swapan K Nath; Guthridge Joel; Beth L Cobb; Daniel B Mirel; Miranda C Marion; Adrienne H Williams; Jasmin Divers; Wei Wang; Summer G Frank; Bahram Namjou; Stacey B Gabriel; Annette T Lee; Peter K Gregersen; timothy wayne behrens; Kimberly E Taylor; Michelle Fernando; Raphael Zidovetzki; Patrick M Gaffney; Jeffrey C Edberg; John D Rioux; Joshua O Ojwang; Judith A James; Joan T Merrill; Gary S Gilkeson; Michael F Seldin; Hong Yin; Emily C Baechler; Quan-Zhen Li; Edward K Wakeland; Gail R Bruner; Kenneth M Kaufman; Jennifer A Kelly
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
Nature genetics 2008;40(2):204-10.
2008: Hitoshi Suzuki; Zina Moldoveanu; Stacy Hall; Rhubell Brown; Huong L Vu; Lea Novak; Bruce A Julian; Milan Tomana; Robert Wyatt; Jeffrey C Edberg; Graciela S Alarcón; Robert P Kimberly; Yasuhiko Tomino; Jiri Mestecky; Jan Novak
IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1.
The Journal of clinical investigation 2008;118(2):629-39.
2008: Amr H Sawalha; Ryan Webb; Shizhong Han; Jennifer A Kelly; Kenneth M Kaufman; Robert P Kimberly; Marta E Alarcón-Riquelme; Judith A James; Timothy J Vyse; Gary S Gilkeson; Chan-Bum Choi; R Hal Scofield; Sang-Cheol Bae; Swapan K Nath; John B Harley
Common variants within MECP2 confer risk of systemic lupus erythematosus.
PloS one 2008;3(3):e1727.
2007: Elizabeth E Brown; Jeffrey C Edberg; Robert P Kimberly
Fc receptor genes and the systemic lupus erythematosus diathesis.
Autoimmunity 2007;40(8):567-81.
2007: James Kelley; Martin R Johnson; Graciela S Alarcón; Robert P Kimberly; Jeffrey C Edberg
Variation in the relative copy number of the TLR7 gene in patients with systemic lupus erythematosus and healthy control subjects.
Arthritis and rheumatism 2007;56(10):3375-8.
2007: Huang-Ge Zhang; Helen Kim; Cunren Liu; Shaohua Yu; Jianhua Wang; William E Grizzle; Robert P Kimberly; Stephen Barnes
Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity.
Biochimica et biophysica acta 2007;1773(7):1116-23.
2007: Shaohua Yu; Cunren Liu; Kaihong Su; Jianhua Wang; Yuelong Liu; Liming Zhang; Chuanyu Li; Yingzi Cong; Robert P Kimberly; William E Grizzle; Carla Falkson; Huang-Ge Zhang
Tumor exosomes inhibit differentiation of bone marrow dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(11):6867-75.
2007: Jianming Wu; Chuanyi Ji; Fenglong Xie; Carl D Langefeld; Kun Qian; Andrew W Gibson; Jeffrey C Edberg; Robert P Kimberly
FcalphaRI (CD89) alleles determine the proinflammatory potential of serum IgA.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3973-82.
2007: Kaihong Su; Hengxuan Yang; Xiaoli Li; Xiaoli Li; Andrew W Gibson; John M Cafardi; Tong Zhou; Jeffrey C Edberg; Robert P Kimberly
Expression profile of FcgammaRIIb on leukocytes and its dysregulation in systemic lupus erythematosus.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):3272-80.
2006: Ji-Yih Chen; Chin Man Wang; Chung-Chun Ma; Shue-Fen Luo; Jeffrey C Edberg; Robert P Kimberly; Jianming Wu
Association of a transmembrane polymorphism of Fcgamma receptor IIb (FCGR2B) with systemic lupus erythematosus in Taiwanese patients.
Arthritis and rheumatism 2006;54(12):3908-17.
2006: Graciela S Alarcón; Gerald McGwin; Michelle Petri; Rosalind Ramsey-Goldman; Barri J Fessler; Luis M Vilá; Jeffrey C Edberg; John D Reveille; Robert P Kimberly
Time to renal disease and end-stage renal disease in PROFILE: a multiethnic lupus cohort.
PLoS medicine 2006;3(10):e396.
2006: Yang Li; Hong Wang; Zheng Wang; Sharmila K Makhija; Donald J Buchsbaum; Albert F LoBuglio; Robert P Kimberly; Tong Zhou
Inducible resistance of tumor cells to tumor necrosis factor-related apoptosis-inducing ligand receptor 2-mediated apoptosis by generation of a blockade at the death domain function.
Cancer research 2006;66(17):8520-8.
2006: Jianhua Wang; Chuanyu Li; Yuelong Liu; Wan Mei; Shaohua Yu; Cunren Liu; Liming Zhang; Xu Cao; Robert P Kimberly; William E Grizzle; Huang-Ge Zhang
JAB1 determines the response of rheumatoid arthritis synovial fibroblasts to tumor necrosis factor-alpha.
The American journal of pathology 2006;169(3):889-902.
2006: David T Redden; Jasmin Divers; Laura Kelly Vaughan; Hemant K Tiwari; Timothy M Beasely; José R Fernández; Robert P Kimberly; Rui Feng; Miguel A Padilla; Nianjun Liu; Michael B Miller; David Allison
Regional admixture mapping and structured association testing: conceptual unification and an extensible general linear model.
PLoS genetics 2006;2(8):e137.
2006: Huang-Ge Zhang; Cunren Liu; Kaihong Su; Kaihun Su; Shaohua Yu; Liming Zhang; Shuangqin Zhang; Jianhua Wang; Xu Cao; William E Grizzle; Robert P Kimberly
A membrane form of TNF-alpha presented by exosomes delays T cell activation-induced cell death.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7385-93.
2006: Cunren Liu; Shaohua Yu; Kurt R Zinn; Jianhua Wang; Liming Zhang; Yujiang Jia; John C Kappes; Stephen Barnes; Robert P Kimberly; William E Grizzle; Huang-Ge Zhang
Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1375-85.
2005: Robert H Carter; Hong Zhao; Ximeng Liu; Marc Pelletier; Winn Chatham; Robert P Kimberly; Tong Zhou
Expression and occupancy of BAFF-R on B cells in systemic lupus erythematosus.
Arthritis and rheumatism 2005;52(12):3943-54.
2005: Jennifer A Croker; Robert P Kimberly
SLE: challenges and candidates in human disease.
Trends in immunology 2005;26(11):580-6.
2005: Xinwen Yang; Jianhua Wang; Cunren Liu; William E Grizzle; Shaohua Yu; Shuangqin Zhang; Stephen Barnes; William J Koopman; John D Mountz; Robert P Kimberly; Huang-Ge Zhang
Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblasts.
The American journal of pathology 2005;167(3):705-19.
2005: Jennifer A Croker; Robert P Kimberly
Genetics of susceptibility and severity in systemic lupus erythematosus.
Current opinion in rheumatology 2005;17(5):529-37.
2005: Alexander Szalai; Jianming Wu; Ethan M Lange; Mark A McCrory; Carl D Langefeld; A Williams; Stanislav Zakharkin; Varghese George; David Allison; G S Cooper; F Xie; Z Fan; Jeffrey C Edberg; Robert P Kimberly
Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate with differences in baseline serum CRP level.
Journal of molecular medicine (Berlin, Germany) 2005;83(6):440-7.
2004: Laura B Hughes; Lindsey A Criswell; Timothy M Beasely; Jeffrey C Edberg; Robert P Kimberly; Larry W Moreland; Michael F Seldin; S Louis Bridges
Genetic risk factors for infection in patients with early rheumatoid arthritis.
Genes and immunity 2004;5(8):641-7.
2004: Hongwei Qin; Jeffrey C Edberg; Andrew W Gibson; Grier P Page; Lihong Teng; Robert P Kimberly
Differential gene expression modulated by the cytoplasmic domain of Fc gamma RIa (CD64) alpha-chain.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(10):6211-9.
2004: Lindsey A Criswell; Raymond F Lum; Kevin N Turner; Blanche Woehl; Yuanqing Zhu; Jinyi Wang; Hemant K Tiwari; Jeffrey C Edberg; Robert P Kimberly; Larry W Moreland; Michael F Seldin; S Louis Bridges
The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept.
Arthritis and rheumatism 2004;50(9):2750-6.
2004: Tong Zhou; Hong Wang; Danlin Luo; Thomas Rowe; Zheng Wang; Robert Jeffrey Hogan; Shihong Qiu; Robert J Bunzel; Guoqiang Huang; Vinod Mishra; Thomas G Voss; Robert P Kimberly; Ming Luo
An exposed domain in the severe acute respiratory syndrome coronavirus spike protein induces neutralizing antibodies.
Journal of virology 2004;78(13):7217-26.
2004: Weimin Liu; Alexander Szalai; Limin Zhao; Di Liu; Flavius Martin; Robert P Kimberly; Tong Zhou; Robert H Carter
Control of spontaneous B lymphocyte autoimmunity with adenovirus-encoded soluble TACI.
Arthritis and rheumatism 2004;50(6):1884-96.
2004: Kaihong Su; Xiaoli Li; Jeffrey C Edberg; Jianming Wu; Polly Ferguson; Robert P Kimberly
A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. II. Differential binding of GATA4 and Yin-Yang1 transcription factors and correlated receptor expression and function.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(11):7192-9.
2004: Kaihong Su; Jianming Wu; Jeffrey C Edberg; Xiaoli Li; Polly Ferguson; Glinda S Cooper; Carl D Langefeld; Robert P Kimberly
A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. I. Regulatory FCGR2B polymorphisms and their association with systemic lupus erythematosus.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(11):7186-91.
2003: Sumiaki Tanaka; Jeffrey C Edberg; Winn Chatham; Giorgio Fassina; Robert P Kimberly
Fc gamma RIIIb allele-sensitive release of alpha-defensins: anti-neutrophil cytoplasmic antibody-induced release of chemotaxins.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):6090-6.
2003: Xiaoli Li; Jianming Wu; Robert H Carter; Jeffrey C Edberg; Kaihong Su; Glinda S Cooper; Robert P Kimberly
A novel polymorphism in the Fcgamma receptor IIB (CD32B) transmembrane region alters receptor signaling.
Arthritis and rheumatism 2003;48(11):3242-52.
2003: Yuanyuan Xu; Alexander Szalai; Tong Zhou; Kurt R Zinn; Tandra R Chaudhuri; Xiaoli Li; William J Koopman; Robert P Kimberly
Fc gamma Rs modulate cytotoxicity of anti-Fas antibodies: implications for agonistic antibody-based therapeutics.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(2):562-8.
2003: Toshiaki Ohtsuka; Donald J Buchsbaum; Patsy Oliver; Sharmila K Makhija; Robert P Kimberly; Tong Zhou
Synergistic induction of tumor cell apoptosis by death receptor antibody and chemotherapy agent through JNK/p38 and mitochondrial death pathway.
Oncogene 2003;22(13):2034-44.
2003: Martha L Sanchez; Graciela S Alarcón; Gerald McGwin; Barri J Fessler; Robert P Kimberly
Can the weighted criteria improve our ability to capture a larger number of lupus patients into observational and interventional studies? A comparison with the American College of Rheumatology criteria.
Lupus 2003;12(6):468-70.
2003: Jianming Wu; Christine Metz; Xiulong Xu; Riichiro Abe; Andrew W Gibson; Jeffrey C Edberg; Jennifer Cooke; Fenglong Xie; Glinda S Cooper; Robert P Kimberly
A novel polymorphic CAAT/enhancer-binding protein beta element in the FasL gene promoter alters Fas ligand expression: a candidate background gene in African American systemic lupus erythematosus patients.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):132-8.
2003: Tong Zhou; Jun Zhang; Robert Carter; Robert P Kimberly
BLyS and B cell autoimmunity.
Current directions in autoimmunity 2003;6():21-37.
2002: Randall S Davis; Glynn Dennis; Mary Odom; Andrew W Gibson; Robert P Kimberly; Peter D Burrows; Max D Cooper
Fc receptor homologs: newest members of a remarkably diverse Fc receptor gene family.
Immunological reviews 2002;190():123-36.
2002: Jeffrey C Edberg; Hongwei Qin; Andrew W Gibson; Arthur M F Yee; Patricia B Redecha; Zena K Indik; Alan D Schreiber; Robert P Kimberly
The CY domain of the Fcgamma RIa alpha-chain (CD64) alters gamma-chain tyrosine-based signaling and phagocytosis.
The Journal of biological chemistry 2002;277(43):41287-93.
2002: Kaihong Su; Jianming Wu; Jeffrey C Edberg; S E McKenzie; Robert P Kimberly
Genomic organization of classical human low-affinity Fcgamma receptor genes.
Genes and immunity 2002;3 Suppl 1():S51-6.
2002: Jeffrey C Edberg; Carl D Langefeld; Jianming Wu; Kathy L Moser; Kenneth M Kaufman; Jennifer Kelly; Vipin Bansal; W Mark Brown; Jane E Salmon; Stephen S Rich; John B Harley; Robert P Kimberly
Genetic linkage and association of Fcgamma receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus.
Arthritis and rheumatism 2002;46(8):2132-40.
2002: Alexander Szalai; Mark A McCrory; G S Cooper; Jianming Wu; Robert P Kimberly
Association between baseline levels of C-reactive protein (CRP) and a dinucleotide repeat polymorphism in the intron of the CRP gene.
Genes and immunity 2002;3(1):14-9.
2002: Tong Zhou; John D Mountz; Robert P Kimberly
Immunobiology of tumor necrosis factor receptor superfamily.
Immunologic research 2002;26(1-3):323-36.
2002: Robert P Kimberly; Jianming Wu; Andrew W Gibson; Kaihong Su; Hongwe Qin; Xiaoli Li; Jeffrey C Edberg
Diversity and duplicity: human FCgamma receptors in host defense and autoimmunity.
Immunologic research 2002;26(1-3):177-89.
2002: Graciela S Alarcón; Gerald McGwin; Michelle Petri; John D Reveille; R Ramsey-Goldman; Robert P Kimberly
Baseline characteristics of a multiethnic lupus cohort: PROFILE.
Lupus 2002;11(2):95-101.
2002: Jianming Wu; Jeffrey C Edberg; Andrew W Gibson; Robert P Kimberly
Conservation of FcepsilonRI gamma chain coding region in normals and in SLE patients.
Lupus 2002;11(1):42-5.
2001: K Ichikawa; W Liu; L Zhao; Z Wang; D Liu; Toshiaki Ohtsuka; H Zhang; J D Mountz; W J Koopman; Robert P Kimberly; Tong Zhou
Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity.
Nature medicine 2001;7(8):954-60.
2001: Andrew W Gibson; Jeffrey C Edberg; Jianming Wu; R G Westendorp; T W Huizinga; Robert P Kimberly
Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosus.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(6):3915-22.
2001: Leland J Yee; Jianming "James" Tang; Andrew W Gibson; Robert P Kimberly; Dirk J van Leeuwen; Richard A Kaslow
Interleukin 10 polymorphisms as predictors of sustained response in antiviral therapy for chronic hepatitis C infection.
Hepatology (Baltimore, Md.) 2001;33(3):708-12.
2001: Winn Chatham; Robert P Kimberly
Treatment of lupus with corticosteroids.
Lupus 2001;10(3):140-7.
2000: Mary-Pat Stein; Jeffrey C Edberg; Robert P Kimberly; E K Mangan; Dwaipayan Bharadwaj; Carolyn Mold; Terry W Du Clos
C-reactive protein binding to FcgammaRIIa on human monocytes and neutrophils is allele-specific.
The Journal of clinical investigation 2000;105(3):369-76.
1999: Jianming Wu; Jeffrey C Edberg; Andrew W Gibson; B Tsao; Robert P Kimberly
Single-nucleotide polymorphisms of T cell receptor zeta chain in patients with systemic lupus erythematosus.
Arthritis and rheumatism 1999;42(12):2601-5.
1999: Jeffrey C Edberg; A M Yee; D S Rakshit; D J Chang; J A Gokhale; Zena K Indik; Alan D Schreiber; Robert P Kimberly
The cytoplasmic domain of human FcgammaRIa alters the functional properties of the FcgammaRI.gamma-chain receptor complex.
The Journal of biological chemistry 1999;274(42):30328-33.
1999: Robert P Kimberly
Genetics of human lupus.
Current directions in autoimmunity 1999;1():99-120.
1998: M Kocher; Jeffrey C Edberg; H B Fleit; Robert P Kimberly
Antineutrophil cytoplasmic antibodies preferentially engage Fc gammaRIIIb on human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(12):6909-14.
1998: Chander Raman; Robert P Kimberly
Differential CD5-dependent regulation of CD5-associated CK2 activity in mature and immature T cells: implication on TCR/CD3-mediated activation.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):5817-20.
1998: Chander Raman; A Kuo; Jessy Deshane; D W Litchfield; Robert P Kimberly
Regulation of casein kinase 2 by direct interaction with cell surface receptor CD5.
The Journal of biological chemistry 1998;273(30):19183-9.
1998: Jeffrey C Edberg; James J Moon; D J Chang; Robert P Kimberly
Differential regulation of human neutrophil FcgammaRIIa (CD32) and FcgammaRIIIb (CD16)-induced Ca2+ transients.
The Journal of biological chemistry 1998;273(14):8071-9.
1997: L A Haseley; J J Wisnieski; M R Denburg; A R Michael-Grossman; E M Ginzler; Mark Gourley; J H Hoffman; Robert P Kimberly; Jane E Salmon
Antibodies to C1q in systemic lupus erythematosus: characteristics and relation to Fc gamma RIIA alleles.
Kidney international 1997;52(5):1375-80.
1997: M Kocher; M E Siegel; Jeffrey C Edberg; Robert P Kimberly
Cross-linking of Fc gamma receptor IIa and Fc gamma receptor IIIb induces different proadhesive phenotypes on human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(8):3940-8.
1997: Jeffrey C Edberg; Robert P Kimberly
Cell type-specific glycoforms of Fc gamma RIIIa (CD16): differential ligand binding.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(8):3849-57.
1997: Jianming Wu; Jeffrey C Edberg; Patricia B Redecha; V Bansal; Paul M Guyre; K Coleman; Jane E Salmon; Robert P Kimberly
A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease.
The Journal of clinical investigation 1997;100(5):1059-70.
1997: Jeffrey C Edberg; E Wainstein; Jianming Wu; E Csernok; M C Sneller; G S Hoffman; E C Keystone; W L Gross; Robert P Kimberly
Analysis of FcgammaRII gene polymorphisms in Wegener's granulomatosis.
Experimental and clinical immunogenetics 1997;14(3):183-95.
1996: Jane E Salmon; S Millard; L A Schachter; Frank C Arnett; E M Ginzler; Mark Gourley; R Ramsey-Goldman; M G Peterson; Robert P Kimberly
Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans.
The Journal of clinical investigation 1996;97(5):1348-54.
1995: Jeffrey C Edberg; C T Lin; D Lau; J C Unkeless; Robert P Kimberly
The Ca2+ dependence of human Fc gamma receptor-initiated phagocytosis.
The Journal of biological chemistry 1995;270(38):22301-7.
1995: Jane E Salmon; S S Millard; N L Brogle; Robert P Kimberly
Fc gamma receptor IIIb enhances Fc gamma receptor IIa function in an oxidant-dependent and allele-sensitive manner.
The Journal of clinical investigation 1995;95(6):2877-85.
1995: Robert P Kimberly; Jane E Salmon; Jeffrey C Edberg
Receptors for immunoglobulin G. Molecular diversity and implications for disease.
Arthritis and rheumatism 1995;38(3):306-14.
1994: A J Porges; P B Redecha; W T Kimberly; E Csernok; W L Gross; Robert P Kimberly
Anti-neutrophil cytoplasmic antibodies engage and activate human neutrophils via Fc gamma RIIa.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(3):1271-80.
1994: E Mysler; Stephen A Paget; Robert P Kimberly
Ciprofloxacin reactions mimicking lupus flares.
Arthritis and rheumatism 1994;37(7):1112-3.
1994: Zena K Indik; Sharon Hunter; M M Huang; X Q Pan; P Chien; C Kelly; Arnold I Levinson; Robert P Kimberly; Alan D Schreiber
The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI.
Experimental hematology 1994;22(7):599-606.
1993: Jane E Salmon; N Brogle; C Brownlie; Jeffrey C Edberg; Robert P Kimberly; Bi-Xing Chen; Bernard F Erlanger
Human mononuclear phagocytes express adenosine A1 receptors. A novel mechanism for differential regulation of Fc gamma receptor function.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(5):2775-85.
1992: A J Porges; P B Redecha; R Doebele; L C Pan; Jane E Salmon; Robert P Kimberly
Novel Fc gamma receptor I family gene products in human mononuclear cells.
The Journal of clinical investigation 1992;90(5):2102-9.
1992: A J Porges; S L Beattie; C Ritchlin; Robert P Kimberly; C L Christian
Patients with systemic lupus erythematosus at risk for Pneumocystis carinii pneumonia.
The Journal of rheumatology 1992;19(8):1191-4.
1992: Jeffrey C Edberg; Robert P Kimberly; Ronald P Taylor
Functional characterization of non-human primate erythrocyte immune adherence receptors: implications for the uptake of immune complexes by the cells of the mononuclear phagocytic system.
European journal of immunology 1992;22(6):1333-9.
1992: Jeffrey C Edberg; Robert P Kimberly
Receptor specific probes for the study of Fc gamma receptor specific function.
Journal of immunological methods 1992;148(1-2):179-87.
1992: Jane E Salmon; Jeffrey C Edberg; N L Brogle; Robert P Kimberly
Allelic polymorphisms of human Fc gamma receptor IIA and Fc gamma receptor IIIB. Independent mechanisms for differences in human phagocyte function.
The Journal of clinical investigation 1992;89(4):1274-81.
1992: Jeffrey C Edberg; Jane E Salmon; Robert P Kimberly
Functional capacity of Fc gamma receptor III (CD16) on human neutrophils.
Immunologic research 1992;11(3-4):239-51.
1991: Jane E Salmon; N L Brogle; Jeffrey C Edberg; Robert P Kimberly
Fc gamma receptor III induces actin polymerization in human neutrophils and primes phagocytosis mediated by Fc gamma receptor II.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(3):997-1004.
1991: Jeffrey C Edberg; Jane E Salmon; M Whitlow; Robert P Kimberly
Preferential expression of human Fc gamma RIIIPMN (CD16) in paroxysmal nocturnal hemoglobinuria. Discordant expression of glycosyl phosphatidylinositol-linked proteins.
The Journal of clinical investigation 1991;87(1):58-67.
1990: Jeffrey C Edberg; M Barinsky; P B Redecha; Jane E Salmon; Robert P Kimberly
Fc gamma RIII expressed on cultured monocytes is a N-glycosylated transmembrane protein distinct from Fc gamma RIII expressed on natural killer cells.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(12):4729-34.
1990: Robert P Kimberly; J W Ahlstrom; M E Click; Jeffrey C Edberg
The glycosyl phosphatidylinositol-linked Fc gamma RIIIPMN mediates transmembrane signaling events distinct from Fc gamma RII.
The Journal of experimental medicine 1990;171(4):1239-55.
1990: Jane E Salmon; Jeffrey C Edberg; Robert P Kimberly
Fc gamma receptor III on human neutrophils. Allelic variants have functionally distinct capacities.
The Journal of clinical investigation 1990;85(4):1287-95.
1989: Robert P Kimberly; Jane E Salmon; Jeffrey C Edberg; Allan Gibofsky
The role of Fc gamma receptors in mononuclear phagocyte system function.
Clinical and experimental rheumatology 1989;7 Suppl 3():S103-8.
1989: Robert P Kimberly; Jeffrey C Edberg; L T Merriam; S B Clarkson; J C Unkeless; Ronald P Taylor
In vivo handling of soluble complement fixing Ab/dsDNA immune complexes in chimpanzees.
The Journal of clinical investigation 1989;84(3):962-70.
1989: Jeffrey C Edberg; P B Redecha; Jane E Salmon; Robert P Kimberly
Human Fc gamma RIII (CD16). Isoforms with distinct allelic expression, extracellular domains, and membrane linkages on polymorphonuclear and natural killer cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(5):1642-9.
1989: Robert P Kimberly; N J Tappe; L T Merriam; P B Redecha; Jeffrey C Edberg; S Schwartzman; J E Valinsky
Carbohydrates on human Fc gamma receptors. Interdependence of the classical IgG and nonclassical lectin-binding sites on human Fc gamma RIII expressed on neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(11):3923-30.
1987: Jane E Salmon; S Kapur; Robert P Kimberly
Opsonin-independent ligation of Fc gamma receptors. The 3G8-bearing receptors on neutrophils mediate the phagocytosis of concanavalin A-treated erythrocytes and nonopsonized Escherichia coli.
The Journal of experimental medicine 1987;166(6):1798-813.
1987: S G Greisman; P B Redecha; Robert P Kimberly; C L Christian
Differences among immune complexes: association of C1q in SLE immune complexes with renal disease.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(3):739-45.
1986: S B Clarkson; Robert P Kimberly; J E Valinsky; M D Witmer; J B Bussel; R L Nachman; J C Unkeless
Blockade of clearance of immune complexes by an anti-Fc gamma receptor monoclonal antibody.
The Journal of experimental medicine 1986;164(2):474-89.
1986: Jane E Salmon; Robert P Kimberly; Allan Gibofsky; M Fotino
Altered phagocytosis by monocytes from HLA-DR2 and DR3-positive healthy adults is Fc gamma receptor specific.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(10):3625-30.
1986: S B Clarkson; J B Bussel; Robert P Kimberly; J E Valinsky; R L Nachman; J C Unkeless
Treatment of refractory immune thrombocytopenic purpura with an anti-Fc gamma-receptor antibody.
The New England journal of medicine 1986;314(19):1236-9.
1986: Robert P Kimberly; Jane E Salmon; Allan Gibofsky
Methyldopa and reticuloendothelial function.
The New England journal of medicine 1986;314(4):248-9.
1984: Jane E Salmon; Robert P Kimberly; Allan Gibofsky; M Fotino
Defective mononuclear phagocyte function in systemic lupus erythematosus: dissociation of Fc receptor-ligand binding and internalization.
Journal of immunology (Baltimore, Md. : 1950) 1984;133(5):2525-31.
1983: E S Schned; Robert D Inman; T M Parris; Robert P Kimberly; P B Redecha; C L Christian
Serial circulating immune complexes and mononuclear phagocyte system function in infective endocarditis.
The Journal of laboratory and clinical medicine 1983;102(6):947-59.
1983: Robert P Kimberly; Allan Gibofsky; Jane E Salmon; M Fotino
Impaired fc-mediated mononuclear phagocyte system clearance in HLA-DR2 and MT1-positive healthy young adults.
The Journal of experimental medicine 1983;157(5):1698-703.
1983: Robert P Kimberly; Michael D Lockshin; R L Sherman; J Mouradian; S Saal
Reversible "end-stage" lupus nephritis. Analysis of patients able to discontinue dialysis.
The American journal of medicine 1983;74(3):361-8.
1983: Robert P Kimberly; T M Parris; Robert D Inman; J S McDougal
Dynamics of mononuclear phagocyte system Fc receptor function in systemic lupus erythematosus. Relation to disease activity and circulating immune complexes.
Clinical and experimental immunology 1983;51(2):261-8.
1982: T M Parris; Robert P Kimberly; Robert D Inman; J S McDougal; A Gibofsky; C L Christian
Defective Fc receptor-mediated function of the mononuclear phagocyte system in lupus nephritis.
Annals of internal medicine 1982;97(4):526-32.
1981: Robert P Kimberly; Michael D Lockshin; R L Sherman; J F Beary; J Mouradian; Jhoong Cheigh
"End-stage" lupus nephritis: clinical course to and outcome on dialysis. Experience with 39 patients.
Medicine 1981;60(4):277-87.
1981: Robert P Kimberly; Michael D Lockshin; R L Sherman; J S McDougal; Robert D Inman; C L Christian
High-dose intravenous methylprednisolone pulse therapy in systemic lupus erythematosus.
The American journal of medicine 1981;70(4):817-24.