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Adi Kimchi

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Anatomy

Living Beings

Mice

Physiology

Concepts & Ideas

Molecular Sequence Data

Genes & Molecular Sequences

Amino Acid Sequence

Phenomena

Phosphorylation

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Co-Publications
Name
11
Berissi, Hanna
11
Resnitzky, Dalia
10
Bialik, Shani
9
Cohen, O
9
Raveh, Tal
8
Eisenstein, Miriam
7
Shani, Gidi
6
Shohat, Galit
6
Kissil, JL
6
Marash, Lea
5
Gozuacik, Devrim
5
Feinstein, Elena
5
Deiss, Louis
5
Yarden, Anat
5
Oren, Moshe

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Publications

TOP 3
Zalckvar Einat; Berissi Hanna; Eisenstein Miriam; Kimchi Adi
Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL.
Eisenberg-Lerner A; Bialik S; Simon H-U; Kimchi A
Life and death partners: apoptosis, autophagy and the cross-talk between them.
Eisenberg-Lerner Avital; Kimchi Adi
The paradox of autophagy and its implication in cancer etiology and therapy.

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All Publications

2009: Zalckvar Einat; Berissi Hanna; Eisenstein Miriam; Kimchi Adi
Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL.
Autophagy 2009;5(5):720-2.
2009: Eisenberg-Lerner A; Bialik S; Simon H-U; Kimchi A
Life and death partners: apoptosis, autophagy and the cross-talk between them.
Cell death and differentiation 2009;16(7):966-75.
2009: Eisenberg-Lerner Avital; Kimchi Adi
The paradox of autophagy and its implication in cancer etiology and therapy.
Apoptosis : an international journal on programmed cell death 2009;14(4):376-91.
2009: Zalckvar Einat; Berissi Hanna; Mizrachy Liat; Idelchuk Yulia; Koren Itay; Eisenstein Miriam; Sabanay Helena; Pinkas-Kramarski Ronit; Kimchi Adi
DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy.
EMBO reports 2009;10(3):285-92.
2009: Liberman Noa; Marash Lea; Kimchi Adi
The translation initiation factor DAP5 is a regulator of cell survival during mitosis.
Cell cycle (Georgetown, Tex.) 2009;8(2):204-9.
2008: Liberman Noa; Dym Orly; Unger Tamar; Albeck Shira; Peleg Yoav; Jacobovitch Yossi; Branzburg Anna; Eisenstein Miriam; Marash Lea; Kimchi Adi
The crystal structure of the C-terminal DAP5/p97 domain sheds light on the molecular basis for its processing by caspase cleavage.
Journal of molecular biology 2008;383(3):539-48.
2008: Reef Sharon; Kimchi Adi
Nucleolar p19ARF, unlike mitochondrial smARF, is incapable of inducing p53-independent autophagy.
Autophagy 2008;4(7):866-9.
2008: Bialik Shani; Berissi Hanna; Kimchi Adi
A high throughput proteomics screen identifies novel substrates of death-associated protein kinase.
Molecular & cellular proteomics : MCP 2008;7(6):1089-98.
2008: Marash Lea; Liberman Noa; Henis-Korenblit Sivan; Sivan Gilad; Reem Eran; Elroy-Stein Orna; Kimchi Adi
DAP5 promotes cap-independent translation of Bcl-2 and CDK1 to facilitate cell survival during mitosis.
Molecular cell 2008;30(4):447-59.
2008: Bialik Shani; Kimchi Adi
Autophagy and tumor suppression: recent advances in understanding the link between autophagic cell death pathways and tumor development.
Advances in experimental medicine and biology 2008;615():177-200.
2007: Eisenberg-Lerner A; Kimchi A
DAP kinase regulates JNK signaling by binding and activating protein kinase D under oxidative stress.
Cell death and differentiation 2007;14(11):1908-15.
2007: Shoval Yishay; Pietrokovski Shmuel; Kimchi Adi
ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene.
PLoS genetics 2007;3(10):1884-93.
2007: Kimchi Adi
Programmed cell death: from novel gene discovery to studies on network connectivity and emerging biomedical implications.
Cytokine & growth factor reviews 2007;18(5-6):435-40.
2007: Reef S; Shifman O; Oren M; Kimchi A
The autophagic inducer smARF interacts with and is stabilized by the mitochondrial p32 protein.
Oncogene 2007;26(46):6677-83.
2007: Maiuri M Chiara; Zalckvar Einat; Kimchi Adi; Kroemer Guido
Self-eating and self-killing: crosstalk between autophagy and apoptosis.
Nature reviews. Molecular cell biology 2007;8(9):741-52.
2007: Gozuacik Devrim; Kimchi Adi
Autophagy and cell death.
Current topics in developmental biology 2007;78():217-45.
2006: Reef Sharon; Kimchi Adi
A smARF way to die: a novel short isoform of p19ARF is linked to autophagic cell death.
Autophagy 2006;2(4):328-30.
2006: Reef Sharon; Zalckvar Einat; Shifman Ohad; Bialik Shani; Sabanay Helena; Oren Moshe; Kimchi Adi
A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death.
Molecular cell 2006;22(4):463-75.
2006: Citri Ami; Harari Daniel; Shohat Galit; Ramakrishnan Parameswaran; Gan Judith; Lavi Sara; Eisenstein Miriam; Kimchi Adi; Wallach David; Pietrokovski Shmuel; Yarden Yosef
Hsp90 recognizes a common surface on client kinases.
The Journal of biological chemistry 2006;281(20):14361-9.
2006: Gozuacik Devrim; Kimchi Adi
DAPk protein family and cancer.
Autophagy 2006;2(2):74-9.
2006: Bialik Shani; Kimchi Adi
The death-associated protein kinases: structure, function, and beyond.
Annual review of biochemistry 2006;75():189-210.
2005: Marash L; Kimchi A
DAP5 and IRES-mediated translation during programmed cell death.
Cell death and differentiation 2005;12(6):554-62.
2005: Llambi Fabien; Lourenço Filipe Calheiros; Gozuacik Devrim; Guix Catherine; Pays Laurent; Del Rio Gabriel; Kimchi Adi; Mehlen Patrick
The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase.
The EMBO journal 2005;24(6):1192-201.
2004: Shani Gidi; Marash Lea; Gozuacik Devrim; Bialik Shani; Teitelbaum Lior; Shohat Galit; Kimchi Adi
Death-associated protein kinase phosphorylates ZIP kinase, forming a unique kinase hierarchy to activate its cell death functions.
Molecular and cellular biology 2004;24(19):8611-26.
2004: Bialik Shani; Kimchi Adi
DAP-kinase as a target for drug design in cancer and diseases associated with accelerated cell death.
Seminars in cancer biology 2004;14(4):283-94.
2004: Mukamel Zohar; Kimchi Adi
Death-associated protein 3 localizes to the mitochondria and is involved in the process of mitochondrial fragmentation during cell death.
The Journal of biological chemistry 2004;279(35):36732-8.
2004: Bialik S; Bresnick A R; Kimchi A
DAP-kinase-mediated morphological changes are localization dependent and involve myosin-II phosphorylation.
Cell death and differentiation 2004;11(6):631-44.
2004: Lévy Delphine; Plu-Bureau Geneviève; Decroix Yves; Hugol Danielle; Rostène William; Kimchi Adi; Gompel Anne
Death-associated protein kinase loss of expression is a new marker for breast cancer prognosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(9):3124-30.
2004: Gozuacik Devrim; Kimchi Adi
Autophagy as a cell death and tumor suppressor mechanism.
Oncogene 2004;23(16):2891-906.
2003: Kimchi Adi
Antisense libraries to isolate tumor suppressor genes.
Methods in molecular biology (Clifton, N.J.) 2003;222():399-412.
2002: Shohat Galit; Shani Gidi; Eisenstein Miriam; Kimchi Adi
The DAP-kinase family of proteins: study of a novel group of calcium-regulated death-promoting kinases.
Biochimica et biophysica acta 2002;1600(1-2):45-50.
2002: Shohat Galit; Spivak-Kroizman Taly; Eisenstein Miriam; Kimchi Adi
The regulation of death-associated protein (DAP) kinase in apoptosis.
European cytokine network 2002;13(4):398-400.
2002: Lo Coco Francisco; Zelent Arthur; Kimchi Adi; Carducci Michael; Gore Steve D; Waxman Samuel
Progress in differentiation induction as a treatment for acute promyelocytic leukemia and beyond.
Cancer research 2002;62(19):5618-21.
2002: Schori Hadas; Yoles Eti; Wheeler Larry A; Raveh Tal; Kimchi Adi; Schwartz Michal
Immune-related mechanisms participating in resistance and susceptibility to glutamate toxicity.
The European journal of neuroscience 2002;16(4):557-64.
2002: Inbal Boaz; Bialik Shani; Sabanay Ilana; Shani Gidi; Kimchi Adi
DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death.
The Journal of cell biology 2002;157(3):455-68.
2002: Henis-Korenblit Sivan; Shani Gidi; Sines Tal; Marash Lea; Shohat Galit; Kimchi Adi
The caspase-cleaved DAP5 protein supports internal ribosome entry site-mediated translation of death proteins.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(8):5400-5.
2002: Pelled Dori; Raveh Tal; Riebeling Christian; Fridkin Mati; Berissi Hanna; Futerman Anthony H; Kimchi Adi
Death-associated protein (DAP) kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neurons.
The Journal of biological chemistry 2002;277(3):1957-61.
2001: Shohat G; Spivak-Kroizman T; Cohen O; Bialik S; Shani G; Berrisi H; Eisenstein M; Kimchi A
The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism.
The Journal of biological chemistry 2001;276(50):47460-7.
2001: Raveh T; Kimchi A
DAP kinase-a proapoptotic gene that functions as a tumor suppressor.
Experimental cell research 2001;264(1):185-92.
2001: Shani G; Henis-Korenblit S; Jona G; Gileadi O; Eisenstein M; Ziv T; Admon A; Kimchi A
Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding.
The EMBO journal 2001;20(5):1099-113.
2001: Cohen O; Kimchi A
DAP-kinase: from functional gene cloning to establishment of its role in apoptosis and cancer.
Cell death and differentiation 2001;8(1):6-15.
2001: Raveh T; Droguett G; Horwitz M S; DePinho R A; Kimchi A
DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation.
Nature cell biology 2001;3(1):1-7.
2000: Raveh T; Berissi H; Eisenstein M; Spivak T; Kimchi A
A functional genetic screen identifies regions at the C-terminal tail and death-domain of death-associated protein kinase that are critical for its proapoptotic activity.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(4):1572-7.
2000: Inbal B; Shani G; Cohen O; Kissil J L; Kimchi A
Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis.
Molecular and cellular biology 2000;20(3):1044-54.
2000: Henis-Korenblit S; Strumpf N L; Goldstaub D; Kimchi A
A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation.
Molecular and cellular biology 2000;20(2):496-506.
1999: Kimchi A
DAP kinase and DAP-3: novel positive mediators of apoptosis.
Annals of the rheumatic diseases 1999;58 Suppl 1():I14-9.
1999: Cohen O; Inbal B; Kissil J L; Raveh T; Berissi H; Spivak-Kroizaman T; Feinstein E; Kimchi A
DAP-kinase participates in TNF-alpha- and Fas-induced apoptosis and its function requires the death domain.
The Journal of cell biology 1999;146(1):141-8.
1999: Kissil J L; Cohen O; Raveh T; Kimchi A
Structure-function analysis of an evolutionary conserved protein, DAP3, which mediates TNF-alpha- and Fas-induced cell death.
The EMBO journal 1999;18(2):353-62.
1998: Levy-Strumpf N; Kimchi A
Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions.
Oncogene 1998;17(25):3331-40.
1998: Kimchi A
DAP genes: novel apoptotic genes isolated by a functional approach to gene cloning.
Biochimica et biophysica acta 1998;1377(2):F13-33.
1997: Inbal B; Cohen O; Polak-Charcon S; Kopolovic J; Vadai E; Eisenbach L; Kimchi A
DAP kinase links the control of apoptosis to metastasis.
Nature 1997;390(6656):180-4.
1997: Kissil J L; Feinstein E; Cohen O; Jones P A; Tsai Y C; Knowles M A; Eydmann M E; Kimchi A
DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene.
Oncogene 1997;15(4):403-7.
1997: Cohen O; Feinstein E; Kimchi A
DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity.
The EMBO journal 1997;16(5):998-1008.
1997: Levy-Strumpf N; Deiss L P; Berissi H; Kimchi A
DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death.
Molecular and cellular biology 1997;17(3):1615-25.
1997: Kissil J L; Kimchi A
Assignment of death associated protein 3 (DAP3) to human chromosome 1q21 by in situ hybridization.
Cytogenetics and cell genetics 1997;77(3-4):252.
1996: Raveh T; Hovanessian A G; Meurs E F; Sonenberg N; Kimchi A
Double-stranded RNA-dependent protein kinase mediates c-Myc suppression induced by type I interferons.
The Journal of biological chemistry 1996;271(41):25479-84.
1996: Deiss L P; Galinka H; Berissi H; Cohen O; Kimchi A
Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha.
The EMBO journal 1996;15(15):3861-70.
1996: Tiefenbrun N; Melamed D; Levy N; Resnitzky D; Hoffman I; Reed S I; Kimchi A
Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest.
Molecular and cellular biology 1996;16(7):3934-44.
1995: Kissil J L; Deiss L P; Bayewitch M; Raveh T; Khaspekov G; Kimchi A
Isolation of DAP3, a novel mediator of interferon-gamma-induced cell death.
The Journal of biological chemistry 1995;270(46):27932-6.
1995: Feinstein E; Druck T; Kastury K; Berissi H; Goodart S A; Overhauser J; Kimchi A; Huebner K
Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively.
Genomics 1995;29(1):305-7.
1995: Deiss L P; Feinstein E; Berissi H; Cohen O; Kimchi A
Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death.
Genes & development 1995;9(1):15-30.
1994: Landesman Y; Bringold F; Kimchi A
p53 undergoes epitopic changes in vitro by sodium-vanadate.
Oncogene 1994;9(4):1241-5.
1993: Levy N; Yonish-Rouach E; Oren M; Kimchi A
Complementation by wild-type p53 of interleukin-6 effects on M1 cells: induction of cell cycle exit and cooperativity with c-myc suppression.
Molecular and cellular biology 1993;13(12):7942-52.
1993: Melamed D; Tiefenbrun N; Yarden A; Kimchi A
Interferons and interleukin-6 suppress the DNA-binding activity of E2F in growth-sensitive hematopoietic cells.
Molecular and cellular biology 1993;13(9):5255-65.
1993: Melamed D; Resnitzky D; Haimov I; Levy N; Pfarr C M; Yaniv M; Kimchi A
Interleukin 6 induces DNA binding activity of AP1 in M1 myeloblastic cells but not in a growth resistant cell derivative.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(8):689-97.
1993: Yonish-Rouach E; Grunwald D; Wilder S; Kimchi A; May E; Lawrence J J; May P; Oren M
p53-mediated cell death: relationship to cell cycle control.
Molecular and cellular biology 1993;13(3):1415-23.
1993: Zafriri D; Argaman M; Canaani E; Kimchi A
Induction of protein-tyrosine-phosphatase activity by interleukin 6 in M1 myeloblastic cells and analysis of possible counteractions by the BCR-ABL oncogene.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(2):477-81.
1992: Kimchi A
Cytokine triggered molecular pathways that control cell cycle arrest.
Journal of cellular biochemistry 1992;50(1):1-9.
1992: Landesman Y; Pagano M; Draetta G; Rotter V; Fusenig N E; Kimchi A
Modifications of cell cycle controlling nuclear proteins by transforming growth factor beta in the HaCaT keratinocyte cell line.
Oncogene 1992;7(8):1661-5.
1992: Resnitzky D; Tiefenbrun N; Berissi H; Kimchi A
Interferons and interleukin 6 suppress phosphorylation of the retinoblastoma protein in growth-sensitive hematopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(1):402-6.
1991: Yonish-Rouach E; Resnitzky D; Lotem J; Sachs L; Kimchi A; Oren M
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6.
Nature 1991;352(6333):345-7.
1991: Yonish-Rouach E; Kimchi A; Rubinstein M
The antiproliferative effect of cyclosporine on hematopoietic and lymphoblastoid cell lines--common mechanistic elements with interferon-alpha.
Transplantation 1991;51(6):1276-82.
1991: Tiefenbrun N; Kimchi A
The involvement of protein kinase C in mediating growth suppressive signals of interferons in hematopoietic cells.
Oncogene 1991;6(6):1001-7.
1991: Deiss L P; Kimchi A
A genetic tool used to identify thioredoxin as a mediator of a growth inhibitory signal.
Science (New York, N.Y.) 1991;252(5002):117-20.
1991: Resnitzky D; Kimchi A
Deregulated c-myc expression abrogates the interferon- and interleukin 6-mediated G0/G1 cell cycle arrest but not other inhibitory responses in M1 myeloblastic cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1991;2(1):33-41.
1988: Kimchi A; Resnitzky D; Ber R; Gat G
Recessive genetic deregulation abrogates c-myc suppression by interferon and is implicated in oncogenesis.
Molecular and cellular biology 1988;8(7):2828-36.
1988: Einat M; Kimchi A
Transfection of fibroblasts with activated c-myc confers resistance to antigrowth effects of interferon.
Oncogene 1988;2(5):485-91.
1988: Kimchi A; Wang X F; Weinberg R A; Cheifetz S; Massagué J
Absence of TGF-beta receptors and growth inhibitory responses in retinoblastoma cells.
Science (New York, N.Y.) 1988;240(4849):196-9.
1987: Bendori R; Resnitzky D; Kimchi A
Changes in p53 mRNA expression during terminal differentiation of murine erythroleukemia cells.
Virology 1987;161(2):607-11.
1987: Kimchi A
Autocrine interferon and the suppression of the c-myc nuclear oncogene.
Interferon 1987;8():85-110.
1986: Yarden A; Kimchi A
Tumor necrosis factor reduces c-myc expression and cooperates with interferon-gamma in HeLa cells.
Science (New York, N.Y.) 1986;234(4782):1419-21.
1986: Resnitzky D; Yarden A; Zipori D; Kimchi A
Autocrine beta-related interferon controls c-myc suppression and growth arrest during hematopoietic cell differentiation.
Cell 1986;46(1):31-40.
1985: Einat M; Resnitzky D; Kimchi A
Inhibitory effects of interferon on the expression of genes regulated by platelet-derived growth factor.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(22):7608-12.
1985: Einat M; Resnitzky D; Kimchi A
Close link between reduction of c-myc expression by interferon and, G0/G1 arrest.
Nature 1985;313(6003):597-600.
1985: Kimchi A; Yarden A; Gat G; Resnitzky D
Reduction of c-myc expression by IFN: further analysis of the sensitive and the resistant phenotype of cells.
Progress in clinical and biological research 1985;202():195-202.
1984: Yarden A; Shure-Gottlieb H; Chebath J; Revel M; Kimchi A
Autogenous production of interferon-beta switches on HLA genes during differentiation of histiocytic lymphoma U937 cells.
The EMBO journal 1984;3(5):969-73.
1982: Revel M F; Kimchi A
Initial characterization of a spontaneous interferon secreted during growth and differentiation of Friend erythroleukemia cells.
Molecular and cellular biology 1982;2(12):1472-80.
1981: Kimchi A; Shure H; Lapidot Y; Rapoport S; Panet A; Revel M
Antimitogenic effects of interferon and (2'-5')-oligoadenylate in synchronized 3T3 fibroblasts.
FEBS letters 1981;134(2):212-6.
1981: Revel M; Kimchi A; Friedman M; Wolf D; Merlin G; Panet A; Rapoport S; Lapidot Y
Cell-regulatory functions of interferon induced enzymes: antimitogenic effect of (2'-5')oligo-A, growth-related variations in (2'-5')oligo-A synthetase, and isolation of its mRNA.
Texas reports on biology and medicine 1981;41():452-62.
1981: Revel M; Wallach D; Merlin G; Schattner A; Schmidt A; Wolf D; Shulman L; Kimchi A
Interferon-induced enzymes: microassays and their applications: purification and assay of (2'-5')-oligoadenylate synthetase and assay of 2'-phosphodiesterase.
Methods in enzymology 1981;79(Pt B):149-61.
1981: Kimchi A; Shure H; Revel M
Anti-mitogenic function of interferon-induced (2'-5')oligo(adenylate) and growth-related variations in enzymes that synthesize and degrade this oligonucleotide.
European journal of biochemistry / FEBS 1981;114(1):5-10.
1980: Revel M; Kimchi A; Shulman L; Fradin A; Shuster R; Yakobson E; Chernajovsky Y; Schmidt A; Shure A; Bendori R
Role of interferon-induced enzymes in the antiviral and antimitogenic effects of interferon.
Annals of the New York Academy of Sciences 1980;350():459-72.

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