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Shinya Kimura

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Seiichiro Katagiri; Shinya Kimura; Taira Maekawa; Yosuke Minami; Tomoki Naoe; Seiichi Okabe; Tetsuzo Tauchi; Kazuma Ohyashiki
Combination of ponatinib with Hedgehog antagonist vismodegib for therapy-resistant BCR-ABL1-positive leukemia.
Kazutaka Koto; Toshikazu Kubo; Taira Maekawa; Takaaki Matsui; Hiroaki Murata; Kazuteru Ryu; Yasushi Sawai; Eishi Ashihara; Naoyuki Horie; Shinya Kimura; Shinji Fushiki
Zoledronic acid significantly enhances radiation‑induced apoptosis against human fibrosarcoma cells by inhibiting radioadaptive signaling.
Eisaburo Sueoka; Naoko Sueoka-Aragane; Choji Taya; Hiromichi Yonekawa; Masaru Ide; Shinya Kimura; Tomoyuki Kitagawa; Yasushi Kubota; Kei Nakachi; Hideaki Nakamura; Akemi Sato; Yusuke Sotomaru; Keiji Tanimoto
Development of lymphoproliferative diseases by hypoxia inducible factor-1alpha is associated with prolonged lymphocyte survival.

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2013: Seiichiro Katagiri; Shinya Kimura; Taira Maekawa; Yosuke Minami; Tomoki Naoe; Seiichi Okabe; Tetsuzo Tauchi; Kazuma Ohyashiki
Combination of ponatinib with Hedgehog antagonist vismodegib for therapy-resistant BCR-ABL1-positive leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(6):1422-32.
2013: Kazutaka Koto; Toshikazu Kubo; Taira Maekawa; Takaaki Matsui; Hiroaki Murata; Kazuteru Ryu; Yasushi Sawai; Eishi Ashihara; Naoyuki Horie; Shinya Kimura; Shinji Fushiki
Zoledronic acid significantly enhances radiation‑induced apoptosis against human fibrosarcoma cells by inhibiting radioadaptive signaling.
International journal of oncology 2013;42(2):525-34.
2013: Eisaburo Sueoka; Naoko Sueoka-Aragane; Choji Taya; Hiromichi Yonekawa; Masaru Ide; Shinya Kimura; Tomoyuki Kitagawa; Yasushi Kubota; Kei Nakachi; Hideaki Nakamura; Akemi Sato; Yusuke Sotomaru; Keiji Tanimoto
Development of lymphoproliferative diseases by hypoxia inducible factor-1alpha is associated with prolonged lymphocyte survival.
PloS one 2013;8(4):e57833.
2013: Seiichi Okabe; Yuko Tanaka; Tetsuzo Tauchi; Shinya Kimura; Taira Maekawa; Kazuma Ohyashiki
Activity of histone deacetylase inhibitors and an Aurora kinase inhibitor in BCR-ABL-expressing leukemia cells: Combination of HDAC and Aurora inhibitors in BCR-ABL-expressing cells.
Cancer cell international 2013;13(1):32.
2012: Shinya Kimura
[Discovery and clinical development of targeted molecular therapeutics].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 8():12-7.
2012: Hidekazu Itamura; Noriyasu Fukushima; Takashi Hisatomi; Tatsuo Ichinohe; Masaru Ide; Seiji Kondo; Yasushi Kubota; Eisaburo Sueoka; Mariko Tanaka-Yoshimura; Chisako Urata; Masako Yokoo; Shinya Kimura
Successful reduced-intensity umbilical cord blood transplant for fulminant hemophagocytic syndrome in an adult with pre-existing rheumatoid arthritis and autoimmune hemolytic anemia.
Leukemia & lymphoma 2012;53(11):2307-9.
2012: Tomomi Nakamura; Akemi Sato; Eisaburo Sueoka; Naoko Sueoka-Aragane; Shinichiro Hayashi; Mitsuharu Hirai; Toshiya Hosomi; Kentaro Iwanaga; Naomi Kobayashi; Kazutoshi Komiya; Shinya Kimura
Application of a highly sensitive detection system for epidermal growth factor receptor mutations in plasma DNA.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012;7(9):1369-81.
2012: Shinya Kimura
[Treatment of imatinib-intolerant or -resistant CML patients].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 2():304-8.
2012: Naomi Kobayashi; Koji Kusaba; Natsuko Naganobu; Zenzo Nagasawa; Naoko Sueoka-Aragane; Hitomi Umeguchi; Katsukiyo Yazawa; Tohru Gonoi; Shinya Kimura; Shinichiro Hayashi
Disseminated Nocardiosis caused by Nocardia concava with acute respiratory failure and central nervous system involvement treated with linezolid.
Internal medicine (Tokyo, Japan) 2012;51(23):3281-5.
2012: Kentaro Iwanaga; Daisuke Mori; Tomomi Nakamura; Naoko Sueoka-Aragane; Shinya Kimura
The long-term survival of a patient with adenosquamous lung carcinoma harboring EGFR-activating mutations who was treated with gefitinib.
Internal medicine (Tokyo, Japan) 2012;51(19):2771-4.
2012: Takashi Sugioka; Kazuo Wakayama; Yasushi Kubota; Shinya Kimura
Severe steroid-resistant thrombocytopenia secondary to cytomegalovirus infection in an immunocompetent adult.
Internal medicine (Tokyo, Japan) 2012;51(13):1747-50.
2011: Ruriko Tanaka; Hisashi Wakita; Hisayuki Yao; Mariko Yoshimura; Eishi Ashihara; Yoshihiro Hayashi; Hideyo Hirai; Kuniaki Itoh; Shinya Kimura; Junia V Melo; Rina Nagao; Kaichi Nishiwaki; Oliver G Ottmann; Sakiko Satake; Ken-Ichi Sawada; Kenshi Suzuki; Naoto Takahashi; Taira Maekawa
Rapid automated detection of ABL kinase domain mutations in imatinib-resistant patients.
Cancer letters 2011;312(2):228-34.
2011: Rina Nagao; Janak Padia; Kathryn Strand; Jeffrey W Strovel; Miki Takeuchi; Ruriko Tanaka; Hisayuki Yao; Eishi Ashihara; Yoshihiro Hayashi; Hideyo Hirai; Shinya Kimura; Taira Maekawa
Growth inhibition of imatinib-resistant CML cells with the T315I mutation and hypoxia-adaptation by AV65--a novel Wnt/β-catenin signaling inhibitor.
Cancer letters 2011;312(1):91-100.
2011: Tomomi Nakamura; Akemi Sato; Eisaburo Sueoka; Naoko Sueoka-Aragane; Norio Ureshino; Tomonori Abe; Shinichiro Hayashi; Mitsuharu Hirai; Toshiya Hosomi; Kentaro Iwanaga; Kazutoshi Komiya; Shinya Kimura
A noninvasive system for monitoring resistance to epidermal growth factor receptor tyrosine kinase inhibitors with plasma DNA.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2011;6(10):1639-48.
2011: Norio Ureshino; Shinichiro Hayashi; Kentaro Iwanaga; Kazutoshi Komiya; Masahiro Mitsuoka; Tomomi Nakamura; Akemi Sato; Eisaburo Sueoka; Naoko Sueoka-Aragane; Yuji Takeda; Shinya Kimura
A fully integrated, automated and rapid detection system for KRAS mutations.
Oncology reports 2011;26(3):609-13.
2011: Chisako Urata; Mariko Yoshimura; Yasushi Kubota; Eisaburo Sueoka; Noriyasu Fukushima; Takashi Hisatomi; Hidekazu Itamura; Shinya Kimura
Lenalidomide in combination with dexamethasone induced rhabdomyolysis in a multiple myeloma patient treated with pravastatin.
International journal of hematology 2011;94(2):216-7.
2011: Shinya Kimura
[Drug development and future scope to BCR-ABL inhibitor for chronic myeloid leukemia].
Gan to kagaku ryoho. Cancer & chemotherapy 2011;38(5):754-8.
2011: Takashi Hisatomi; Naoko Sueoka-Aragane; Akemi Sato; Rika Tomimasu; Masaru Ide; Akihiro Kurimasa; Kazuya Okamoto; Shinya Kimura; Eisaburo Sueoka
NK314 potentiates antitumor activity with adult T-cell leukemia-lymphoma cells by inhibition of dual targets on topoisomerase II{alpha} and DNA-dependent protein kinase.
Blood 2011;117(13):3575-84.
2011: Miki Takeuchi; Eishi Ashihara; Yohko Yamazaki; Shinya Kimura; Yoko Nakagawa; Ruriko Tanaka; Hisayuki Yao; Rina Nagao; Yoshihiro Hayashi; Hideyo Hirai; Taira Maekawa
Rakicidin A effectively induces apoptosis in hypoxia adapted Bcr-Abl positive leukemic cells.
Cancer science 2011;102(3):591-6.
2011: Norio Ureshino; Naoko Aragane; Tomomi Nakamura; Masaru Ide; Sakiko Mochinaga; Noriyasu Fukushima; Shinichiro Hayashi; Eizaburo Sueoka; Shinya Kimura
A fully integrated and automated detection system for single nucleotide polymorphisms of UGT1A1 and CYP2C19.
Oncology research 2011;19(3-4):111-4.
2011: Kazuki Sakai; Eri Kawata; Eishi Ashihara; Yoko Nakagawa; Akira Yamauchi; Hisayuki Yao; Rina Nagao; Ruriko Tanaka; Asumi Yokota; Miki Takeuchi; Hideyo Hirai; Shinya Kimura; Mitsuomi Hirashima; Norio Yoshimura; Taira Maekawa
Galectin-9 ameliorates acute GVH disease through the induction of T-cell apoptosis.
European journal of immunology 2011;41(1):67-75.
2010: Ruriko Tanaka; Matthew S Squires; Shinya Kimura; Asumi Yokota; Rina Nagao; Takahiro Yamauchi; Miki Takeuchi; Hisayuki Yao; Matthias Reule; Tomoko Smyth; John F Lyons; Neil T Thompson; Eishi Ashihara; Oliver G Ottmann; Taira Maekawa
Activity of the multitargeted kinase inhibitor, AT9283, in imatinib-resistant BCR-ABL-positive leukemic cells.
Blood 2010;116(12):2089-95.
2010: Masahide Hamaguchi; Takahiro Seno; Aihiro Yamamoto; Masataka Kohno; Masatoshi Kadoya; Hidetaka Ishino; Eishi Ashihara; Shinya Kimura; Yoshinori Tsubakimoto; Hiroki Takata; Toshikazu Yoshikawa; Taira Maekawa; Yutaka Kawahito
Loxoprofen Sodium, a Non-Selective NSAID, Reduces Atherosclerosis in Mice by Reducing Inflammation.
Journal of clinical biochemistry and nutrition 2010;47(2):138-47.
2010: Eri Kawata; Eishi Ashihara; Yoko Nakagawa; Takahiro Kiuchi; Mai Ogura; Hisayuku Yao; Kazuki Sakai; Ruriko Tanaka; Rina Nagao; Asumi Yokota; Miki Takeuchi; Shinya Kimura; Hideyo Hirai; Taira Maekawa
A combination of a DNA-chimera siRNA against PLK-1 and zoledronic acid suppresses the growth of malignant mesothelioma cells in vitro.
Cancer letters 2010;294(2):245-53.
2010: Kazuteru Ryu; Hiroaki Murata; Kazutaka Koto; Naoyuki Horie; Takaaki Matsui; Yasunori Nishigaki; Tomoya Sakabe; Hideyuki Takeshita; Megumi Itoi; Shinya Kimura; Eishi Ashihara; Taira Maekawa; Shinji Fushiki; Toshikazu Kubo
Combined effects of bisphosphonate and radiation on osteosarcoma cells.
Anticancer research 2010;30(7):2713-20.
2010: Junya Kuroda; Mio Yamamoto; Hisao Nagoshi; Tsutomu Kobayashi; Nana Sasaki; Yuji Shimura; Shigeo Horiike; Shinya Kimura; Akira Yamauchi; Mitsuomi Hirashima; Masafumi Taniwaki
Targeting activating transcription factor 3 by Galectin-9 induces apoptosis and overcomes various types of treatment resistance in chronic myelogenous leukemia.
Molecular cancer research : MCR 2010;8(7):994-1001.
2010: Kazutaka Koto; Hiroaki Murata; Shinya Kimura; Naoyuki Horie; Takaaki Matsui; Yasunori Nishigaki; Kazuteru Ryu; Tomoya Sakabe; Megumi Itoi; Eishi Ashihara; Taira Maekawa; Shinji Fushiki; Toshikazu Kubo
Zoledronic acid inhibits proliferation of human fibrosarcoma cells with induction of apoptosis, and shows combined effects with other anticancer agents.
Oncology reports 2010;24(1):233-9.
2010: Kinya Ito; Tomoki Aoyama; Kenichi Fukiage; Seiji Otsuka; Moritoshi Furu; Yonghui Jin; Akira Nasu; Michiko Ueda; Yasunari Kasai; Eishi Ashihara; Shinya Kimura; Taira Maekawa; Akira Kobayashi; Shinya Yoshida; Hideo Niwa; Takanobu Otsuka; Takashi Nakamura; Junya Toguchida
A novel method to isolate mesenchymal stem cells from bone marrow in a closed system using a device made by nonwoven fabric.
Tissue engineering. Part C, Methods 2010;16(1):81-91.
2010: Takashi Ushiki; Shinae Kizaka-Kondoh; Eishi Ashihara; Shotaro Tanaka; Masayoshi Masuko; Hideyo Hirai; Shinya Kimura; Yoshifusa Aizawa; Taira Maekawa; Masahiro Hiraoka
Noninvasive tracking of donor cell homing by near-infrared fluorescence imaging shortly after bone marrow transplantation.
PloS one 2010;5(6):e11114.
2009: Masanobu Oshima; Y Kato; R Masuda; Shinya Kimura; yukiko yamashita
Effect of turbulence on feeding intensity and survival of Japanese flounder Paralichthys olivaceus pelagic larvae.
Journal of fish biology 2009;75(7):1639-47.
2009: Seiji Matsumoto; Fumihiro Tanaka; Kiyoshi Sato; Shinya Kimura; Taira Maekawa; Seiki Hasegawa; Hiromi Wada
Monitoring with a non-invasive bioluminescent in vivo imaging system of pleural metastasis of lung carcinoma.
Lung cancer (Amsterdam, Netherlands) 2009;66(1):75-9.
2009: Kazutaka Koto; Naoyuki Horie; Shinya Kimura; Hiroaki Murata; Tomoya Sakabe; Takaaki Matsui; Motonobu Watanabe; Souichi Adachi; Taira Maekawa; Shinji Fushiki; Toshikazu Kubo
Clinically relevant dose of zoledronic acid inhibits spontaneous lung metastasis in a murine osteosarcoma model.
Cancer letters 2009;274(2):271-8.
2008: Yuri Kamitsuji; Junya Kuroda; Shinya Kimura; Shinya Toyokuni; Ken-ichiro Watanabe; Eishi Ashihara; Hajime Tanaka; Yoshiki Yui; Masahiko Watanabe; Hiroshi Matsubara; Y Mizushima; Yoshimi Hiraumi; Eri Kawata; Toshikazu Yoshikawa; Taira Maekawa; Tatsutoshi Nakahata; Shuji Adachi
The Bcr-Abl kinase inhibitor INNO-406 induces autophagy and different modes of cell death execution in Bcr-Abl-positive leukemias.
Cell death and differentiation 2008;15(11):1712-22.
2008: Eri Kawata; Eishi Ashihara; Shinya Kimura; Kazumasa Takenaka; Kiyoshi Sato; Ruriko Tanaka; Asumi Yokota; Yuri Kamitsuji; Miki Takeuchi; Junya Kuroda; Fumihiro Tanaka; Toshikazu Yoshikawa; Taira Maekawa
Administration of PLK-1 small interfering RNA with atelocollagen prevents the growth of liver metastases of lung cancer.
Molecular cancer therapeutics 2008;7(9):2904-12.
2008: Ruriko Tanaka; Junya Kuroda; William Stevenson; Eishi Ashihara; Takayuki Ishikawa; Tomohiko Taki; Yutaka Kobayashi; Yuri Kamitsuji; Eri Kawata; Miki Takeuchi; Yoshihide Murotani; Asumi Yokota; Mitsuharu Hirai; Satoshi Majima; Masafumi Taniwaki; Taira Maekawa; Shinya Kimura
Fully automated and super-rapid system for the detection of JAK2V617F mutation.
Leukemia research 2008;32(9):1462-7.
2008: Junya Kuroda; Yuri Kamitsuji; Shinya Kimura; Eishi Ashihara; Eri Kawata; Yoko Nakagawa; Miki Takeuichi; Yoshihide Murotani; Asumi Yokota; Ruriko Tanaka; Michael Andreeff; Masafumi Taniwaki; Taira Maekawa
Anti-myeloma effect of homoharringtonine with concomitant targeting of the myeloma-promoting molecules, Mcl-1, XIAP, and beta-catenin.
International journal of hematology 2008;87(5):507-15.
2008: Yasuyuki Deguchi; Shinya Kimura; Eishi Ashihara; Tomoko Niwa; Keiko Hodohara; Yoshihide Fujiyama; Taira Maekawa
Comparison of imatinib, dasatinib, nilotinib and INNO-406 in imatinib-resistant cell lines.
Leukemia research 2008;32(6):980-3.
2008: Kazuho Shimura; Eishi Ashihara; Chihiro Shimazaki; Shinsaku Matsunaga; Kyoko Taniguchi; Hitoji Uchiyama; Yosuke Matsumoto; Shinya Kimura; Hiroaki Matsubara; Masafumi Taniwaki; Taira Maekawa
Circulating endothelial progenitor cells decreased in patients with sclerodermatous chronic graft-versus-host disease.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2008;14(4):426-37.
2008: Junya Kuroda; Yosuke Matsumoto; Ruriko Tanaka; Kayoko Kurita; Tsutomu Kobayashi; Daisuke Shimizu; Shinya Kimura; Eishi Ashihara; Shigeo Horiike; Chihiro Shimazaki; Masafumi Taniwaki
JAK2V617F-positive essential thrombocythemia and multiple myeloma with IGH/CCND1 gene translocation coexist, but originate from separate clones.
Acta haematologica 2008;120(3):177-81.
2008: Junya Kuroda; Shinya Kimura; Michael Andreeff; Eishi Ashihara; Yuri Kamitsuji; Asumi Yokota; Eri Kawata; Miki Takeuchi; Ruriko Tanaka; Yoshihide Murotani; Yosuke Matsumoto; Hideo Tanaka; Andreas Strasser; Masafumi Taniwaki; Taira Maekawa
ABT-737 is a useful component of combinatory chemotherapies for chronic myeloid leukaemias with diverse drug-resistance mechanisms.
British journal of haematology 2008;140(2):181-90.
2007: Yutaka Kobayashi; Yoshihide Murotani; Nana Sawai; Teruaki Akaogi; Masami Sako; Hideo Hayashi; Yosuke Matsumoto; Junya Kuroda; Kenichi Nomura; Shigeo Horiike; Chihiro Shimazaki; Shinya Kimura; Toshikazu Yoshikawa; Masafumi Taniwaki
[Combination therapy with rituximab and cladribine for patients with follicular lymphoma].
Gan to kagaku ryoho. Cancer & chemotherapy 2007;34(10):1623-7.
2007: Taira Maekawa; Eishi Ashihara; Shinya Kimura
The Bcr-Abl tyrosine kinase inhibitor imatinib and promising new agents against Philadelphia chromosome-positive leukemias.
International journal of clinical oncology 2007;12(5):327-40.
2007: Junya Kuroda; Shinya Kimura; A Strasser; M Andreeff; L A O'Reilly; Eishi Ashihara; Yuri Kamitsuji; Asumi Yokota; Eri Kawata; M Takeuchi; R Tanaka; Y Tabe; Masafumi Taniwaki; Taira Maekawa
Apoptosis-based dual molecular targeting by INNO-406, a second-generation Bcr-Abl inhibitor, and ABT-737, an inhibitor of antiapoptotic Bcl-2 proteins, against Bcr-Abl-positive leukemia.
Cell death and differentiation 2007;14(9):1667-77.
2007: Kimiko Yurugi; Shinya Kimura; Eishi Ashihara; Hiroaki Tsuji; A Kawata; Yuri Kamitsuji; R Hishida; M Takegawa; Hiroto Egawa; Taira Maekawa
Rapid and accurate measurement of anti-A/B IgG antibody in ABO-unmatched living donor liver transplantation by surface plasmon resonance.
Transfusion medicine (Oxford, England) 2007;17(2):97-106.
2007: Ryo Uchida; Eishi Ashihara; Kiyoshi Sato; Shinya Kimura; Junya Kuroda; Miki Takeuchi; Eri Kawata; Kyoko Taniguchi; Masashi Okamoto; Kazuho Shimura; Yasushi Kiyono; Chihiro Shimazaki; Masafumi Taniwaki; Taira Maekawa
Gamma delta T cells kill myeloma cells by sensing mevalonate metabolites and ICAM-1 molecules on cell surface.
Biochemical and biophysical research communications 2007;354(2):613-8.
2007: Eishi Ashihara; Hiroaki Tsuji; Hiromi Sakashita; Hironori Haga; Kimiko Yurugi; Shinya Kimura; Hiroto Egawa; Toshiaki Manabe; Shinji Uemoto; Taira Maekawa
Antidonor antibody in patients receiving ABO-identical and HLA-mismatched living donor liver transplants: effect on survival.
Transplantation 2007;83(4):506-9.
2007: Shinya Kimura
[Novel molecular target therapy].
Nihon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 1():46-51.
2007: Tomoko Niwa; Tetsuo Asaki; Shinya Kimura
NS-187 (INNO-406), a Bcr-Abl/Lyn dual tyrosine kinase inhibitor.
Analytical chemistry insights 2007;2():93-106.
2007: Eri Kawata; Junya Kuroda; Katsuya Wada; Makie Yoshida; Kenji Kamiuchi; Ichiko Nakayama-Harusato; Shinya Kimura; Taira Maekawa; Yoshihiro Kitagawa
Hypereosinophilic syndrome accompanied by Buerger's disease-like femoral arterial occlusions.
Internal medicine (Tokyo, Japan) 2007;46(23):1919-22.
2007: Yutaka Kobayashi; Yuri Kamitsuji; Junya Kuroda; Sei Tsunoda; Nobuhiko Uoshima; Shinya Kimura; Katsuya Wada; Yosuke Matsumoto; Kenichi Nomura; Shigeo Horiike; Chihiro Shimazaki; Toshikazu Yoshikawa; Masafumi Taniwaki
Comparison of human herpes virus 8 related primary effusion lymphoma with human herpes virus 8 unrelated primary effusion lymphoma-like lymphoma on the basis of HIV: report of 2 cases and review of 212 cases in the literature.
Acta haematologica 2007;117(3):132-44.
2007: Asumi Yokota; Shinya Kimura; Satohiro Masuda; Eishi Ashihara; Junya Kuroda; Kiyoshi Sato; Yuri Kamitsuji; Eri Kawata; Yasuyuki Deguchi; Yoshimasa URASAKI; Yasuhito Terui; Martin Ruthardt; Takanori Ueda; Kiyohiko Hatake; Ken-ichi Inui; Taira Maekawa
INNO-406, a novel BCR-ABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph+ leukemia cells in the central nervous system, and cyclosporine A augments its in vivo activity.
Blood 2007;109(1):306-14.
2006: Kiyoshi Sato; Takeshi Yuasa; Masaki Nogawa; Shinya Kimura; Hidekazu Segawa; Asumi Yokota; Taira Maekawa
A third-generation bisphosphonate, minodronic acid (YM529), successfully prevented the growth of bladder cancer in vitro and in vivo.
British journal of cancer 2006;95(10):1354-61.
2006: Shinya Kimura
Second generation Abl kinase inhibitors and novel compounds to eliminate the Bcr-Abl/T315I clone.
Recent patents on anti-cancer drug discovery 2006;1(3):347-55.
2006: Haruna Naito; Shinya Kimura; Yohei Nakaya; Haruna Naruoka; Shinya Kimura; Shinsaku Ito; Tatsushi Wakayama; Taira Maekawa; Kazuko Hirabayashi
In vivo antiproliferative effect of NS-187, a dual Bcr-Abl/Lyn tyrosine kinase inhibitor, on leukemic cells harbouring Abl kinase domain mutations.
Leukemia research 2006;30(11):1443-6.
2006: Shinya Kimura; Eishi Ashihara; Taira Maekawa
New tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia.
Current pharmaceutical biotechnology 2006;7(5):371-9.
2005: Shinya Kimura; Haruna Naito; Hidekazu Segawa; Junya Kuroda; Takeshi Yuasa; Kiyoshi Sato; Asumi Yokota; Yuri Kamitsuji; Eri Kawata; Eishi Ashihara; Yohei Nakaya; Haruna Naruoka; Tatsushi Wakayama; Kimio Nasu; Tetsuo Asaki; Tomoko Niwa; Kazuko Hirabayashi; Taira Maekawa
NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia.
Blood 2005;106(12):3948-54.
2005: Kimiko Yurugi; Shinya Kimura; Taira Maekawa
[Detection of antibodies specific for blood group antigens A and B].
Rinsho byori. The Japanese journal of clinical pathology 2005;53(11):1011-8.
2005: Kiyoshi Sato; Shinya Kimura; Hidekazu Segawa; Asumi Yokota; Seiji Matsumoto; Junya Kuroda; Masaki Nogawa; Takeshi Yuasa; Yasushi Kiyono; Hiromi Wada; Taira Maekawa
Cytotoxic effects of gammadelta T cells expanded ex vivo by a third generation bisphosphonate for cancer immunotherapy.
International journal of cancer. Journal international du cancer 2005;116(1):94-9.
2005: Hidekazu Segawa; Shinya Kimura; Junya Kuroda; Kiyoshi Sato; Asumi Yokota; Eri Kawata; Yuri Kamitsuji; Eishi Ashihara; Takeshi Yuasa; Yoshihide Fujiyama; Oliver G Ottmann; Taira Maekawa
Zoledronate synergises with imatinib mesylate to inhibit Ph primary leukaemic cell growth.
British journal of haematology 2005;130(4):558-60.
2005: Takeshi Yuasa; Norimi Niwa; Shinya Kimura; Hiroaki Tsuji; Kimiko Yurugi; Hiroto Egawa; Koichi Tanaka; Hiroaki Asano; Taira Maekawa
Intraoperative blood loss during living donor liver transplantation: an analysis of 635 recipients at a single center.
Transfusion 2005;45(6):879-84.
2005: Masaki Nogawa; Takeshi Yuasa; Shinya Kimura; Motoyoshi Tanaka; Junya Kuroda; Kiyoshi Sato; Asumi Yokota; Hidekazu Segawa; Yoshinobu Toda; Susumu Kageyama; Tatsuhiro Yoshiki; Yusaku Okada; Taira Maekawa
Intravesical administration of small interfering RNA targeting PLK-1 successfully prevents the growth of bladder cancer.
The Journal of clinical investigation 2005;115(4):978-85.
2005: Hidekazu Segawa; Shinya Kimura; Junya Kuroda; Kiyoshi Sato; Masaki Nogawa; Takeshi Yuasa; Asumi Yokota; Keiko Hodohara; Yoshihide Fujiyama; Taira Maekawa
The anti-leukemic efficacy of the third generation bisphosphonate ONO5920/YM529.
Leukemia research 2005;29(4):451-7.
2005: Takeshi Yuasa; Hiroaki Tsuji; Shinya Kimura; Norimi Niwa; Kimiko Yurugi; Hiroto Egawa; Koichi Tanaka; Etsuko Maruya; Hiro-O Saji; Hiroaki Asano; Taira Maekawa
Human leukocyte antigens in Japanese patients with biliary atresia: retrospective analysis of patients who underwent living donor liver transplantation.
Human immunology 2005;66(3):295-300.
2005: Masaki Nogawa; Takeshi Yuasa; Shinya Kimura; Junya Kuroda; Kiyoshi Sato; Hidekazu Segawa; Asumi Yokota; Taira Maekawa
Monitoring luciferase-labeled cancer cell growth and metastasis in different in vivo models.
Cancer letters 2005;217(2):243-53.
2005: Takeshi Yuasa; Masaki Nogawa; Shinya Kimura; Asumi Yokota; Kiyoshi Sato; Hidekazu Segawa; Junya Kuroda; Taira Maekawa
A third-generation bisphosphonate, minodronic acid (YM529), augments the interferon alpha/beta-mediated inhibition of renal cell cancer cell growth both in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(2 Pt 1):853-9.
2005: Masaki Nogawa; Takeshi Yuasa; Shinya Kimura; Junya Kuroda; Hidekazu Segawa; Kiyoshi Sato; Asumi Yokota; Mitsutera Koizumi; Taira Maekawa
Zoledronic acid mediates Ras-independent growth inhibition of prostate cancer cells.
Oncology research 2005;15(1):1-9.
2005: Shinya Kimura; Kimiko Yurugi; Hidekazu Segawa; Junya Kuroda; Kiyoshi Sato; Masaki Nogawa; Takeshi Yuasa; Hiroto Egawa; Koichi Tanaka; Taira Maekawa
Rapid quantitation of immunoglobulin G antibodies specific for blood group antigens A and B by surface plasmon resonance.
Transfusion 2005;45(1):56-62.
2005: Seiji Matsumoto; Shinya Kimura; Hidekazu Segawa; Junya Kuroda; Takeshi Yuasa; Kiyoshi Sato; Masaki Nogawa; Fumihiro Tanaka; Taira Maekawa; Hiromi Wada
Efficacy of the third-generation bisphosphonate, zoledronic acid alone and combined with anti-cancer agents against small cell lung cancer cell lines.
Lung cancer (Amsterdam, Netherlands) 2005;47(1):31-9.
2005: Shinya Kimura; Chihiro Ito; Naoto Jyoko; Hidekazu Segawa; Junya Kuroda; Masayuki Okada; Souichi Adachi; Tatsutoshi Nakahata; Takeshi Yuasa; Valdir Cechinel Filho; Hiroshi Furukawa; Taira Maekawa
Inhibition of leukemic cell growth by a novel anti-cancer drug (GUT-70) from calophyllum brasiliense that acts by induction of apoptosis.
International journal of cancer. Journal international du cancer 2005;113(1):158-65.
2004: Junya Kuroda; Shinya Kimura; Hidekazu Segawa; Kiyoshi Sato; Seiji Matsumoto; Masaki Nogawa; Takeshi Yuasa; Yutaka Kobayashi; Toshikazu Yoshikawa; Oliver G Ottmann; Taira Maekawa
p53-independent anti-tumor effects of the nitrogen-containing bisphosphonate zoledronic acid.
Cancer science 2004;95(2):186-92.
2004: Shinya Kimura; Junya Kuroda; Hidekazu Segawa; Kiyoshi Sato; Masaki Nogawa; Takeshi Yuasa; Oliver G Ottmann; Taira Maekawa
Antiproliferative efficacy of the third-generation bisphosphonate, zoledronic acid, combined with other anticancer drugs in leukemic cell lines.
International journal of hematology 2004;79(1):37-43.
2003: Junya Kuroda; Shinya Kimura; Hidekazu Segawa; Yutaka Kobayashi; Toshikazu Yoshikawa; Yoshimasa URASAKI; Takanori Ueda; Fumio Enjo; Harukuni Tokuda; Oliver G Ottmann; Taira Maekawa
The third-generation bisphosphonate zoledronate synergistically augments the anti-Ph+ leukemia activity of imatinib mesylate.
Blood 2003;102(6):2229-35.
2003: Junya Kuroda; Shinya Kimura; Yutaka Kobayashi; Naoto Jyoko; Yuri Kamitsuji; Yoshihide Murotani; Wataru Fukuda; Teruaki Akaogi; Hideo Hayashi; Toshikazu Yoshikawa; Taira Maekawa
Variable manifestation in natural killer cell leukaemia.
Clinical and laboratory haematology 2003;25(4):239-45.
2002: Yoshihide Murotani; Junya Kuroda; Shinya Kimura; K Terao; E Fukiya; M Ozawa; Yutaka Kobayashi; Toshikazu Yoshikawa
Non-myeloablative haematopoietic stem cell transplantation for severe aplastic anaemia with various complications.
Clinical and laboratory haematology 2002;24(5):303-6.
2002: Eri Kawata; Junya Kuroda; Shinya Kimura; Yuri Kamitsuji; Yutaka Kobayashi; Toshikazu Yoshikawa
Aplastic anemia evolving into overt myelodysplastic syndrome/acute myeloid leukemia with t(3;5)(p25;q31).
Cancer genetics and cytogenetics 2002;137(2):91-4.
2002: Naoto Jyoko; Junya Kuroda; Shinya Kimura; Yutaka Kobayashi; Toshikazu Yoshikawa
Comprehensive cytogenetic study by spectral karyotyping on blastic natural killer cell leukemia/lymphoma.
American journal of hematology 2002;69(3):234-5.
2002: Junya Kuroda; Shinya Kimura; Yutaka Kobayashi; Katsuya Wada; Nobuhiko Uoshima; Toshikazu Yoshikawa
Unusual myelodysplastic syndrome with the initial presentation mimicking idiopathic thrombocytopenic purpura.
Acta haematologica 2002;108(3):139-43.
2001: Shinya Kimura; Junya Kuroda; Teruaki Akaogi; Hideo Hayashi; Yutaka Kobayashi; M Kondo
Trisomy 8 involved in myelodysplastic syndromes as a risk factor for intestinal ulcers and thrombosis--Behçet's syndrome.
Leukemia & lymphoma 2001;42(1-2):115-21.
2001: Shinya Kimura; Naoki Kakazu; Junya Kuroda; Teruaki Akaogi; Hideo Hayashi; K Nishida; Tatsuo Abe
Agranular CD4+CD56+ blastic natural killer leukemia/lymphoma.
Annals of hematology 2001;80(4):228-31.
2001: Shinya Kimura; Junya Kuroda; Teruaki Akaogi; Hideo Hayashi; Y Ogino; Yutaka Kobayashi; Toshikazu Yoshikawa
Treatment of steroid-resistant idiopathic thrombocytopenic purpura in pregnancy with repeated high-dose intravenous immunoglobulin.
Haematologia 2001;31(3):263-5.
2000: Junya Kuroda; Shinya Kimura; Teruaki Akaogi; Hideo Hayashi; Tatsuo Abe; Yutaka Kobayashi; M Kondo
Primary cardiac lymphoma with variant Burkitt-type translocation, t(8;22)(q24;q11)
American journal of hematology 2000;65(4):327-8.
2000: Junya Kuroda; Shinya Kimura; Teruaki Akaogi; Hideo Hayashi; K Nishida; Naoki Kakazu; Tatsuo Abe
Aggressive natural killer cell leukemia/lymphoma: a comprehensive cytogenetic study by spectral karyotyping.
Annals of hematology 2000;79(9):519-22.
2000: Junya Kuroda; Shinya Kimura; Teruaki Akaogi; Hideo Hayashi; K Nishida; M Taniwaki; K Kashima; Tatsuo Abe; Yutaka Kobayashi; M Kondo
c-myc overexpression is not mandatory in aggressive-phase multiple myeloma with Burkitt's type translocation.
Annals of hematology 2000;79(9):514-8.
2000: S Chikayama; T Sugano; Y Takahashi; M Ikeda; Shinya Kimura; Yutaka Kobayashi; M Kondo
Nuclear accumulation of p53 protein and apoptosis induced by various anticancer agents, u.v.-irradiation and heat shock in primary normal human skin fibroblasts.
International journal of oncology 2000;16(6):1117-24.
2000: Junya Kuroda; Shinya Kimura; Teruaki Akaogi; Hideo Hayashi; T Yamano; Y Sasai; S Horiike; M Taniwaki; Tatsuo Abe; Yutaka Kobayashi; M Kondo
Myelodysplastic syndrome with clonal eosinophilia accompanied by eosinophilic pulmonary interstitial infiltration.
Acta haematologica 2000;104(2-3):119-23.
2000: K Uchiyama; Yutaka Kobayashi; R Tanaka; Y Takahashi; S Chikayama; M Ikeda; Nobuhiko Uoshima; Shinya Kimura; K Tanaka; Katsuya Wada; M Ozawa; M Kondo
Primary malignant lymphoma of the central nervous system presenting with ascites and pleural effusion.
Haematologia 2000;30(2):143-8.
1998: T Kidchob; Shinya Kimura; Y Imanishi
Degradation and release profile of microcapsules made of poly[L-lactic acid-co-L-lysine(Z)].
Journal of controlled release : official journal of the Controlled Release Society 1998;54(3):283-92.
1998: T Kidchob; Shinya Kimura; Y Imanishi
Amphiphilic poly(Ala)-b-poly(Sar) microspheres loaded with hydrophobic drug.
Journal of controlled release : official journal of the Controlled Release Society 1998;51(2-3):241-8.
1998: Yutaka Kobayashi; Y Takahashi; S Chikayama; M Ikeda; Nobuhiko Uoshima; K Tanaka; Shinya Kimura; Katsuya Wada; T Sugano; M Ozawa; M Kondo
[DNA and RNA contents of megakaryocytes using acridine orange staining].
Rinsho byori. The Japanese journal of clinical pathology 1998;46(2):139-43.
1998: T Kidchob; Shinya Kimura; Y Imanishi
Thermoresponsive release from poly(Glu(OMe))-block-poly(Sar) microcapsules with surface-grafting of poly(N-isopropylacrylamide).
Journal of controlled release : official journal of the Controlled Release Society 1998;50(1-3):205-14.
1998: S Chikayama; Shinya Kimura; Yutaka Kobayashi; T Abe; T Maekawa; M Kondo
Effects of daunorubicin on cell growth, cell cycle and induction of apoptosis in HL-60 cells.
Haematologia 1998;29(2):115-21.
1997: M Ueda; Yutaka Kobayashi; K Yoshimori; Y Takahashi; S Chikayama; M Ikeda; Nobuhiko Uoshima; Shinya Kimura; K Tanaka; Katsuya Wada; M Ozawa; M Kondou; K Kawa; M Inoue
[Epstein-Barr virus-infected T-cell malignancy in an adult patient with Behçet's disease-like symptoms].
[Rinshō ketsueki] The Japanese journal of clinical hematology 1997;38(8):657-62.
1997: Yutaka Kobayashi; Y Takahashi; S Chikayama; M Ikeda; Nobuhiko Uoshima; Shinya Kimura; K Tanaka; Katsuya Wada; M Ozawa; T Sugano; N Maruo; M Kondo
Comparison of the DNA content of megakaryocytes identified immunologically with that identified morphologically.
Histochemistry and cell biology 1997;108(2):115-20.