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Toshikiro Kimura

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Ken-Ichi Ogawara; Keita Un; Yuta Yoshizawa; Tomoya Araki; Toshikiro Kimura; Kazutaka Higaki
Nanoparticle-based passive drug targeting to tumors: considerations and implications for optimization.
Tomoya Araki; Toshikiro Kimura; Yusuke Kono; Ken-ichi Ogawara; Tsutomu Ono; Takaichi Watanabe; Kazutaka Higaki
Formulation and evaluation of paclitaxel-loaded polymeric nanoparticles composed of polyethylene glycol and polylactic acid block copolymer.
Daisuke Inoue; Hidemasa Katsumi; Toshikiro Kimura; Ken-ichi Ogawara; Toshiyasu Sakane; Akira Yamamoto; Tomoyuki Furubayashi; Kazutaka Higaki; Yutaka Higashi
In vitro evaluation of nasal mucociliary clearance using excised rat nasal septum.

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2013: Ken-Ichi Ogawara; Keita Un; Yuta Yoshizawa; Tomoya Araki; Toshikiro Kimura; Kazutaka Higaki
Nanoparticle-based passive drug targeting to tumors: considerations and implications for optimization.
Biological & pharmaceutical bulletin 2013;36(5):698-702.
2012: Tomoya Araki; Toshikiro Kimura; Yusuke Kono; Ken-ichi Ogawara; Tsutomu Ono; Takaichi Watanabe; Kazutaka Higaki
Formulation and evaluation of paclitaxel-loaded polymeric nanoparticles composed of polyethylene glycol and polylactic acid block copolymer.
Biological & pharmaceutical bulletin 2012;35(8):1306-13.
2012: Daisuke Inoue; Hidemasa Katsumi; Toshikiro Kimura; Ken-ichi Ogawara; Toshiyasu Sakane; Akira Yamamoto; Tomoyuki Furubayashi; Kazutaka Higaki; Yutaka Higashi
In vitro evaluation of nasal mucociliary clearance using excised rat nasal septum.
Biological & pharmaceutical bulletin 2012;35(6):889-94.
2012: Mamoru Naruse; Ken-ichi Ogawara; Toshikiro Kimura; Ryoji Konishi; Kazutaka Higaki
Development of transdermal therapeutic formulation of CNS5161, a novel N-methyl-D-aspartate receptor antagonist, by utilizing pressure-sensitive adhesives I.
Biological & pharmaceutical bulletin 2012;35(3):321-8.
2011: Naoki Kamada; Toshikiro Kimura; Tadashi Mukai; Toru Nishibayashi; Masaaki Odomi; Ken-ichi Ogawara; Keigo Yamada; Kazutaka Higaki
Sex differences in pharmacokinetics of cilostazol in rats.
Xenobiotica; the fate of foreign compounds in biological systems 2011;41(10):903-13.
2011: Yuta Yoshizawa; Yusuke Kono; Ken-ichi Ogawara; Toshikiro Kimura; Kazutaka Higaki
PEG liposomalization of paclitaxel improved its in vivo disposition and anti-tumor efficacy.
International journal of pharmaceutics 2011;412(1-2):132-41.
2009: Chie Takayama; Fuyuki Mukaizawa; Takuya Fujita; Ken-ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Amino acids suppress apoptosis induced by sodium laurate, an absorption enhancer.
Journal of pharmaceutical sciences 2009;98(12):4629-38.
2009: Akiko Nozaki; Toshikiro Kimura; Hideyuki Ito; Tsutomu Hatano
Interaction of polyphenolic metabolites with human serum albumin: a circular dichroism study.
Chemical & pharmaceutical bulletin 2009;57(9):1019-23.
2009: Toshikiro Kimura
[Analysis of factors governing drug absorption and their improvement].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2009;129(8):911-23.
2009: Takahiro Kimoto; Masashi Takanashi; Hironori Mukai; Ken-ichi Ogawara; Toshikiro Kimura; Kazutaka Higaki
Effect of adrenergic stimulation on drug absorption via passive diffusion in Caco-2 cells.
International journal of pharmaceutics 2009;368(1-2):31-6.
2009: Fuyuki Mukaizawa; Koji Taniguchi; Masateru Miyake; Ken-ichi Ogawara; Masaaki Odomi; Kazutaka Higaki; Toshikiro Kimura
Novel oral absorption system containing polyamines and bile salts enhances drug transport via both transcellular and paracellular pathways across Caco-2 cell monolayers.
International journal of pharmaceutics 2009;367(1-2):103-8.
2009: Akiko Nozaki; Mami Hori; Toshikiro Kimura; Hideyuki Ito; Tsutomu Hatano
Interaction of polyphenols with proteins: binding of (-)-epigallocatechin gallate to serum albumin, estimated by induced circular dichroism.
Chemical & pharmaceutical bulletin 2009;57(2):224-8.
2009: Ken-ichi Ogawara; Keita Un; Ken-ichi Tanaka; Kazutaka Higaki; Toshikiro Kimura
In vivo anti-tumor effect of PEG liposomal doxorubicin (DOX) in DOX-resistant tumor-bearing mice: Involvement of cytotoxic effect on vascular endothelial cells.
Journal of controlled release : official journal of the Controlled Release Society 2009;133(1):4-10.
2008: Jun-ichi Jinno; Naoki Kamada; Masateru Miyake; Keigo Yamada; Tadashi Mukai; Masaaki Odomi; Hajime Toguchi; Gary G Liversidge; Kazutaka Higaki; Toshikiro Kimura
In vitro-in vivo correlation for wet-milled tablet of poorly water-soluble cilostazol.
Journal of controlled release : official journal of the Controlled Release Society 2008;130(1):29-37.
2008: Tamer Shehata; Ken-ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Prolongation of residence time of liposome by surface-modification with mixture of hydrophilic polymers.
International journal of pharmaceutics 2008;359(1-2):272-9.
2008: Ken-ichi Ogawara; Keita Un; Keiko Minato; Ken-Ichi Tanaka; Kazutaka Higaki; Toshikiro Kimura
Determinants for in vivo anti-tumor effects of PEG liposomal doxorubicin: importance of vascular permeability within tumors.
International journal of pharmaceutics 2008;359(1-2):234-40.
2008: Jun-ichi Yokoe; Shiho Sakuragi; Kayoko Yamamoto; Takuya Teragaki; Ken-ichi Ogawara; Kazutaka Higaki; Naohisa Katayama; Toshiya Kai; Makoto Sato; Toshikiro Kimura
Albumin-conjugated PEG liposome enhances tumor distribution of liposomal doxorubicin in rats.
International journal of pharmaceutics 2008;353(1-2):28-34.
2008: Yukiko Metsugi; Yoshihiro Miyaji; Ken-ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Appearance of double peaks in plasma concentration-time profile after oral administration depends on gastric emptying profile and weight function.
Pharmaceutical research 2008;25(4):886-95.
2008: Yoshitsugu Fujioka; Yukiko Metsugi; Ken-Ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Evaluation of in vivo dissolution behavior and GI transit of griseofulvin, a BCS class II drug.
International journal of pharmaceutics 2008;352(1-2):36-43.
2007: Susumu Nagayama; Ken-ichi Ogawara; Yoshiko Fukuoka; Kazutaka Higaki; Toshikiro Kimura
Time-dependent changes in opsonin amount associated on nanoparticles alter their hepatic uptake characteristics.
International journal of pharmaceutics 2007;342(1-2):215-21.
2007: Yoshitsugu Fujioka; Keitaro Kadono; Yasuko Fujie; Yukiko Metsugi; Ken-ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Prediction of oral absorption of griseofulvin, a BCS class II drug, based on GITA model: utilization of a more suitable medium for in-vitro dissolution study.
Journal of controlled release : official journal of the Controlled Release Society 2007;119(2):222-8.
2007: Naoki Nagahara; Yohko Akiyama; Kazutaka Higaki; Toshikiro Kimura
Animal models for predicting potency of oral sustained-release adhesive microspheres in humans.
International journal of pharmaceutics 2007;331(1):46-53.
2007: Susumu Nagayama; Ken-ichi Ogawara; Keiko Minato; Yoshiko Fukuoka; Yoshinobu Takakura; Mitsuru Hashida; Kazutaka Higaki; Toshikiro Kimura
Fetuin mediates hepatic uptake of negatively charged nanoparticles via scavenger receptor.
International journal of pharmaceutics 2007;329(1-2):192-8.
2007: Kentaro Furumoto; Jun-ichi Yokoe; Ken-ichi Ogawara; Sayuri Amano; Maki Takaguchi; Kazutaka Higaki; Toshiya Kai; Toshikiro Kimura
Effect of coupling of albumin onto surface of PEG liposome on its in vivo disposition.
International journal of pharmaceutics 2007;329(1-2):110-6.
2006: Masateru Miyake; Takanori Minami; Hajime Toguchi; Masaaki Odomi; Ken-ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Importance of bile acids for novel oral absorption system containing polyamines to improve intestinal absorption.
Journal of controlled release : official journal of the Controlled Release Society 2006;115(2):130-3.
2006: Tomoyuki Okuda; Kenta Kadotsuji; Chie Takayama; Kiyonori Hanada; Fuyuki Mukaizawa; Ken-ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Involvement of intracellular Ca2+ dynamics in cytoprotective action by amino acids and cytotoxicity by sodium laurate, an absorption enhancer.
Journal of pharmaceutical sciences 2006;95(10):2256-65.
2006: Nobuyuki Tanaka; Keiji Imai; Kazuto Okimoto; Satoshi Ueda; Yuji Tokunaga; Rinta Ibuki; Kazutaka Higaki; Toshikiro Kimura
Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine (II): in vivo evaluation.
Journal of controlled release : official journal of the Controlled Release Society 2006;112(1):51-6.
2006: Masateru Miyake; Takanori Minami; Masao Hirota; Hajime Toguchi; Masaaki Odomi; Ken-ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Novel oral formulation safely improving intestinal absorption of poorly absorbable drugs: utilization of polyamines and bile acids.
Journal of controlled release : official journal of the Controlled Release Society 2006;111(1-2):27-34.
2006: Jun-ichi Jinno; Naoki Kamada; Masateru Miyake; Keigo Yamada; Tadashi Mukai; Masaaki Odomi; Hajime Toguchi; Gary G Liversidge; Kazutaka Higaki; Toshikiro Kimura
Effect of particle size reduction on dissolution and oral absorption of a poorly water-soluble drug, cilostazol, in beagle dogs.
Journal of controlled release : official journal of the Controlled Release Society 2006;111(1-2):56-64.
2006: Masateru Miyake; Takanori Minami; Yoshikazu Oka; Naoki Kamada; Hiroyuki Yamazaki; Yusuke Kato; Tadashi Mukai; Hajime Toguchi; Masaaki Odomi; Ken-ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Optimization of suppository preparation containing sodium laurate and taurine that can safely improve rectal absorption of rebamipide.
Biological & pharmaceutical bulletin 2006;29(2):330-5.
2006: Ken-ichi Ogawara; Joanna M Kułdo; Koen Oosterhuis; Bart-Jan Kroesen; Marianne G Rots; Christian Trautwein; Toshikiro Kimura; Hidde J Haisma; Grietje Molema
Functional inhibition of NF-kappaB signal transduction in alphavbeta3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IkappaB gene.
Arthritis research & therapy 2006;8(1):R32.
2005: Nobuyuki Tanaka; Keiji Imai; Kazuto Okimoto; Satoshi Ueda; Yuji Tokunaga; Atsuo Ohike; Rinta Ibuki; Kazutaka Higaki; Toshikiro Kimura
Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine.
Journal of controlled release : official journal of the Controlled Release Society 2005;108(2-3):386-95.
2005: Toshihito Takatori; Kazumitsu Yamamoto; Toshikazu Yamaguchi; Kazutaka Higaki; Toshikiro Kimura
Design of controlled-release morphine suppositories containing polyglycerol ester of fatty acid.
Biological & pharmaceutical bulletin 2005;28(8):1480-4.
2005: Chomchan Amnuaikit; Itsue Ikeuchi; Ken-ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Skin permeation of propranolol from polymeric film containing terpene enhancers for transdermal use.
International journal of pharmaceutics 2005;289(1-2):167-78.
2005: Kazutaka Higaki; Kazuki Nakayama; T Suyama; Chomchan Amnuaikit; Ken-ichi Ogawara; Toshikiro Kimura
Enhancement of topical delivery of drugs via direct penetration by reducing blood flow rate in skin.
International journal of pharmaceutics 2005;288(2):227-33.
2005: Hideo Hiraoka; Naoji Kimura; Yumiko Furukawa; Ken-ichi Ogawara; Toshikiro Kimura; Kazutaka Higaki
Up-regulation of P-glycoprotein expression in small intestine under chronic serotonin-depleted conditions in rats.
The Journal of pharmacology and experimental therapeutics 2005;312(1):248-55.
2004: Ken-ichi Ogawara; Kentaro Furumoto; Susumu Nagayama; Keiko Minato; Kazutaka Higaki; Toshiya Kai; Toshikiro Kimura
Pre-coating with serum albumin reduces receptor-mediated hepatic disposition of polystyrene nanosphere: implications for rational design of nanoparticles.
Journal of controlled release : official journal of the Controlled Release Society 2004;100(3):451-5.
2004: Masateru Miyake; Naoki Kamada; Yoshikazu Oka; Tadashi Mukai; Takanori Minami; Hajime Toguchi; Masaaki Odomi; Ken-ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Development of suppository formulation safely improving rectal absorption of rebamipide, a poorly absorbable drug, by utilizing sodium laurate and taurine.
Journal of controlled release : official journal of the Controlled Release Society 2004;99(1):63-71.
2004: Toshihito Takatori; Norihito Shimono; Kazutaka Higaki; Toshikiro Kimura
Evaluation of sustained release suppositories prepared with fatty base including solid fats with high melting points.
International journal of pharmaceutics 2004;278(2):275-82.
2004: Kazutaka Higaki; Miki Sone; Ken-ichi Ogawara; Toshikiro Kimura
Regulation of drug absorption from small intestine by enteric nervous system I: a poorly absorbable drug via passive diffusion.
Drug metabolism and pharmacokinetics 2004;19(3):198-205.
2004: Kentaro Furumoto; Susumu Nagayama; Ken-ichi Ogawara; Yoshinobu Takakura; Mitsuru Hashida; Kazutaka Higaki; Toshikiro Kimura
Hepatic uptake of negatively charged particles in rats: possible involvement of serum proteins in recognition by scavenger receptor.
Journal of controlled release : official journal of the Controlled Release Society 2004;97(1):133-41.
2003: Kazunari Yamashita; Toshiomi Nakate; Kazuto Okimoto; Atsuo Ohike; Yuji Tokunaga; Rinta Ibuki; Kazutaka Higaki; Toshikiro Kimura
Establishment of new preparation method for solid dispersion formulation of tacrolimus.
International journal of pharmaceutics 2003;267(1-2):79-91.
2003: Seiji Ohtani; Ken-ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Casein enhances stability of peptides in intestinal lumen: role of digested products of casein.
Pharmaceutical research 2003;20(11):1746-51.
2003: Seiji Ohtani; Kyoko Shirasu; Ken-ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Evaluation of inhibitory activity of casein on proteases in rat intestine.
Pharmaceutical research 2003;20(4):611-7.
2003: Masateru Miyake; Yoshikazu Oka; Takanori Minami; Hajime Toguchi; Masaaki Odomi; Ken-ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Combinatorial use of sodium laurate with taurine or L-glutamine enhances colonic absorption of rebamipide, poorly absorbable antiulcer drug, without any serious histopathological mucosal damages.
Journal of pharmaceutical sciences 2003;92(4):911-21.
2003: Jun-ichi Yokoe; Norio Iwasaki; Shunji Haruta; Keitaro Kadono; Ken-ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Analysis and prediction of absorption behavior of colon-targeted prodrug in rats by GI-transit-absorption model.
Journal of controlled release : official journal of the Controlled Release Society 2003;86(2-3):305-13.
2002: Kentaro Furumoto; Ken-ichi Ogawara; Susumu Nagayama; Yoshinobu Takakura; Mitsuru Hashida; Kazutaka Higaki; Toshikiro Kimura
Important role of serum proteins associated on the surface of particles in their hepatic disposition.
Journal of controlled release : official journal of the Controlled Release Society 2002;83(1):89-96.
2002: Kazutaka Higaki; Masahide Asai; Takayuki Suyama; Kazuki Nakayama; Ken-ichi Ogawara; Toshikiro Kimura
Estimation of intradermal disposition kinetics of drugs: II. Factors determining penetration of drugs from viable skin to muscular layer.
International journal of pharmaceutics 2002;239(1-2):129-41.
2002: Yoko Endo; Kiyonori Hanada; Masateru Miyake; Ken-ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Mechanisms of cytoprotective effect of amino acids on local toxicity caused by sodium laurate, a drug absorption enhancer, in intestinal epithelium.
Journal of pharmaceutical sciences 2002;91(3):730-43.
2002: Shunji Haruta; Keiichi Kawai; Ryuichi Nishii; Seishi Jinnouchi; Ken ichi Ogawara; Kazutaka Higaki; Shozo Tamura; Kazuhiko Arimori; Toshikiro Kimura
Prediction of plasma concentration-time curve of orally administered theophylline based on a scintigraphic monitoring of gastrointestinal transit in human volunteers.
International journal of pharmaceutics 2002;233(1-2):179-90.
2002: Toshikiro Kimura; Kazutaka Higaki
Gastrointestinal transit and drug absorption.
Biological & pharmaceutical bulletin 2002;25(2):149-64.
2002: Toshikiro Kimura; Hitoshi Yamano; Akihiro Tanaka; Tomohiro Matsumura; Minoru Ueda; Ken-ichi Ogawara; Kazutaka Higaki
Transport of D-glucose across cultured stratified cell layer of human oral mucosal cells.
The Journal of pharmacy and pharmacology 2002;54(2):213-9.
2002: Keitaro Kadono; Jun-ichi Yokoe; Ken-ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Analysis and prediction of absorption behavior for theophylline orally administered as powders based on gastrointestinal-transit-absorption (Gita) model.
Drug metabolism and pharmacokinetics 2002;17(4):307-15.
2002: Ken-ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Major determinants in hepatic disposition of polystyrene nanospheres: implication for rational design of particulate drug carriers.
Critical reviews in therapeutic drug carrier systems 2002;19(4-5):277-306.
2001: Ken-ichi Ogawara; Kentaro Furumoto; Yoshinobu Takakura; Mitsuru Hashida; Kazutaka Higaki; Toshikiro Kimura
Surface hydrophobicity of particles is not necessarily the most important determinant in their in vivo disposition after intravenous administration in rats.
Journal of controlled release : official journal of the Controlled Release Society 2001;77(3):191-8.
2001: T Yata; Y Endo; M Sone; Ken-ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Amino acids protect epithelial cells from local toxicity by absorption enhancer, sodium laurate.
Journal of pharmaceutical sciences 2001;90(10):1456-65.
2001: Kentaro Furumoto; Ken-ichi Ogawara; M Yoshida; Yoshinobu Takakura; Mitsuru Hashida; Kazutaka Higaki; Toshikiro Kimura
Biliary excretion of polystyrene microspheres depends on the type of receptor-mediated uptake in rat liver.
Biochimica et biophysica acta 2001;1526(2):221-6.
2001: Kazutaka Higaki; T Yata; M Sone; Ken-ichi Ogawara; Toshikiro Kimura
Estimation of absorption enhancement by medium-chain fatty acids in rat large intestine.
Research communications in molecular pathology and pharmacology 2001;109(3-4):231-40.
2000: Toshikiro Kimura; N Iwasaki; Jun-ichi Yokoe; S Haruta; Y Yokoo; Ken-ichi Ogawara; Kazutaka Higaki
Analysis and prediction of absorption profile including hepatic first-pass metabolism of N-methyltyramine, a potent stimulant of gastrin release present in beer, after oral ingestion in rats by gastrointestinal-transit-absorption model.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(5):577-81.
1999: Ken-ichi Ogawara; M Yoshida; Yoshinobu Takakura; Mitsuru Hashida; Kazutaka Higaki; Toshikiro Kimura
Interaction of polystyrene microspheres with liver cells: roles of membrane receptors and serum proteins.
Biochimica et biophysica acta 1999;1472(1-2):165-72.
1999: Ken-ichi Ogawara; M Yoshida; J Kubo; M Nishikawa; Yoshinobu Takakura; Mitsuru Hashida; Kazutaka Higaki; Toshikiro Kimura
Mechanisms of hepatic disposition of polystyrene microspheres in rats: effects of serum depend on the sizes of microspheres.
Journal of controlled release : official journal of the Controlled Release Society 1999;61(3):241-50.
1999: Y Oyama; H Yamano; A Ohkuma; Ken-ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Carrier-mediated transport systems for glucose in mucosal cells of the human oral cavity.
Journal of pharmaceutical sciences 1999;88(8):830-4.
1999: Ken-ichi Ogawara; M Yoshida; Kazutaka Higaki; Toshikiro Kimura; K Shiraishi; M Nishikawa; Yoshinobu Takakura; Mitsuru Hashida
Hepatic uptake of polystyrene microspheres in rats: effect of particle size on intrahepatic distribution.
Journal of controlled release : official journal of the Controlled Release Society 1999;59(1):15-22.
1999: Kazuki Nakayama; H Matsuura; M Asai; Ken-ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Estimation of intradermal disposition kinetics of drugs: I. Analysis by compartment model with contralateral tissues.
Pharmaceutical research 1999;16(2):302-8.
1999: Ken-ichi Ogawara; M Yoshida; Kentaro Furumoto; Yoshinobu Takakura; Mitsuru Hashida; Kazutaka Higaki; Toshikiro Kimura
Uptake by hepatocytes and biliary excretion of intravenously administered polystyrene microspheres in rats.
Journal of drug targeting 1999;7(3):213-21.
1998: K Sugimoto; M Yoshida; T Yata; Kazutaka Higaki; Toshikiro Kimura
Evaluation of poly(vinyl alcohol)-gel spheres containing chitosan as dosage form to control gastrointestinal transit time of drugs.
Biological & pharmaceutical bulletin 1998;21(11):1202-6.
1998: S Yagi; K Nakayama; Y Kurosaki; Kazutaka Higaki; Toshikiro Kimura
Factors determining drug residence in skin during transdermal absorption: studies on beta-blocking agents.
Biological & pharmaceutical bulletin 1998;21(11):1195-201.
1998: S Haruta; N Iwasaki; Ken-ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Absorption behavior of orally administered drugs in rats treated with propantheline.
Journal of pharmaceutical sciences 1998;87(9):1081-5.
1998: Y Kurosaki; K Yano; Toshikiro Kimura
Perfusion cells for studying regional variation in oral mucosal permeability in humans. 2. A specialized transport mechanism in D-glucose absorption exists in dorsum of tongue.
Journal of pharmaceutical sciences 1998;87(5):613-5.
1998: Y Emi; D Tsunashima; Ken-ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Role of P-glycoprotein as a secretory mechanism in quinidine absorption from rat small intestine.
Journal of pharmaceutical sciences 1998;87(3):295-9.
1997: Toshikiro Kimura; Yusuke Murakawa; M Ohno; S Ohtani; Kazutaka Higaki
Gastrointestinal absorption of recombinant human insulin-like growth factor-I in rats.
The Journal of pharmacology and experimental therapeutics 1997;283(2):611-8.
1997: Kazutaka Higaki; Y Matsumoto; R Fujimoto; Y Kurosaki; Toshikiro Kimura
Pharmacokinetics of recombinant human insulin-like growth factor-I in diabetic rats.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(11):1324-7.
1997: Y Kurosaki; K Yano; Toshikiro Kimura
Perfusion cells for studying regional variation in oral-mucosal permeability in humans. I: Kinetic aspects in oral-mucosal absorption of alkylparabens.
Pharmaceutical research 1997;14(9):1241-5.
1997: Kazutaka Higaki; Y Matsumoto; R Fujimoto; Y Kurosaki; Toshikiro Kimura
Developmental changes in pharmacokinetics of recombinant human insulin-like growth factor-I in rats.
Research communications in molecular pathology and pharmacology 1997;97(2):115-24.
1997: Taiji Nakayama; T Sawamoto; T Karino; M Matsumura; Kenji Sasaki; Y Kurosaki; Toshikiro Kimura
Biopharmaceutical studies on drug/conjugated-metabolite interactions. III. Effect of acetaminophen sulfate and its positional isomers on the pharmacokinetics of acetaminophen in rats.
Biological & pharmaceutical bulletin 1997;20(5):522-9.
1997: T Sawamoto; S Haruta; Y Kurosaki; Kazutaka Higaki; Toshikiro Kimura
Prediction of the plasma concentration profiles of orally administered drugs in rats on the basis of gastrointestinal transit kinetics and absorbability.
The Journal of pharmacy and pharmacology 1997;49(4):450-7.
1996: Z Wang; M Okamoto; Y Kurosaki; T Nakayama; Toshikiro Kimura
Pharmacokinetics of glycyrrhizin in rats with D-galactosamine-induced hepatic disease.
Biological & pharmaceutical bulletin 1996;19(6):901-4.
1996: Toshikiro Kimura; K Sato; K Sugimoto; R Tao; T Murakami; Y Kurosaki; T Nakayama
Oral administration of insulin as poly(vinyl alcohol)-gel spheres in diabetic rats.
Biological & pharmaceutical bulletin 1996;19(6):897-900.
1996: K Iwata; K Matsuda; Y Kurosaki; T Nakayama; H Nakajima; Toshikiro Kimura
Disposition of intravenously administered adenosine 5'-phosphosulfate (APS) in rats.
Biological & pharmaceutical bulletin 1996;19(3):438-43.
1996: T Sawamoto; Y Kurosaki; Toshikiro Kimura; T Nakayama
Pharmacokinetics of acetaminophen sulfate after oral administration in rats: analysis of plasma profiles exhibiting a non-linear second peak.
Biological & pharmaceutical bulletin 1996;19(1):77-82.
1995: Toshikiro Kimura; N Hatano; M Wada; K Iwata; Y Kurosaki; T Nakayama; T Yamaura; H Nakajima
Disposition of diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) in rats.
Biological & pharmaceutical bulletin 1995;18(11):1556-9.
1995: Z Wang; M Nishioka; Y Kurosaki; T Nakayama; Toshikiro Kimura
Gastrointestinal absorption characteristics of glycyrrhizin from glycyrrhiza extract.
Biological & pharmaceutical bulletin 1995;18(9):1238-41.
1995: K Iwata; S Haruki; Toshikiro Kimura
High-performance liquid chromatographic determination of diadenosine 5',5'"-p1,p4-tetraphosphate with precolumn fluorescence derivatization and its application to metabolism study in whole blood.
Journal of chromatography. B, Biomedical applications 1995;667(2):339-43.
1995: K Iwata; H Nakajima; Toshikiro Kimura
Ca2+ dependency of diadenosine 5',5"'-p1,p4-tetraphosphate degradation in dog plasma.
Biological & pharmaceutical bulletin 1995;18(5):788-90.
1994: Z Wang; Y Kurosaki; T Nakayama; Toshikiro Kimura
Mechanism of gastrointestinal absorption of glycyrrhizin in rats.
Biological & pharmaceutical bulletin 1994;17(10):1399-403.
1994: T Yamao; H Nakagami; K Furuhama; T Onodera; Y Kurosaki; T Nakayama; Toshikiro Kimura
Pharmacokinetics of tolbutamide following intravenous and oral administrations in rats with obstructive jaundice.
Biological & pharmaceutical bulletin 1994;17(5):691-5.
1994: Toshikiro Kimura; K Sudo; Y Kanzaki; K Miki; Y Takeichi; Y Kurosaki; T Nakayama
Drug absorption from large intestine: physicochemical factors governing drug absorption.
Biological & pharmaceutical bulletin 1994;17(2):327-33.
1994: Toshikiro Kimura; Y Kanzaki; Y Matsumoto; M Mandai; Y Kurosaki; T Nakayama
Disposition of recombinant human insulin-like growth factor-I in normal and hypophysectomized rats.
Biological & pharmaceutical bulletin 1994;17(2):310-5.
1994: T Yamaguchi; K Sasaki; Y Kurosaki; T Nakayama; Toshikiro Kimura
Biopharmaceutical evaluation of salicylazosulfanilic acid as a novel colon-targeted prodrug of 5-aminosalicylic acid.
Journal of drug targeting 1994;2(2):123-31.
1993: Toshikiro Kimura; S Nakayama; T Yamao; Y Kurosaki; T Nakayama
Pharmacokinetics of indocyanine green in rats with experimentally induced hepatic diseases.
Biological & pharmaceutical bulletin 1993;16(11):1140-5.
1993: T Kai; M Nakazono; Y Kurosaki; T Nakayama; Toshikiro Kimura
Keratinized epithelial transport of beta-blocking agents. III. Evaluation of enhancing effect on percutaneous absorption using model lipid liposomes.
Biological & pharmaceutical bulletin 1993;16(8):801-5.
1993: T Kai; T Isami; Y Kurosaki; T Nakayama; Toshikiro Kimura
Keratinized epithelial transport of beta-blocking agents. II. Evaluation of barrier property of stratum corneum by using model lipid systems.
Biological & pharmaceutical bulletin 1993;16(3):284-7.
1992: T Kai; T Isami; K Kobata; Y Kurosaki; T Nakayama; Toshikiro Kimura
Keratinized epithelial transport of beta-blocking agents. I. Relationship between physicochemical properties of drugs and the flux across rat skin and hamster cheek pouch.
Chemical & pharmaceutical bulletin 1992;40(9):2498-504.
1991: Y Kurosaki; T Takatori; H Nishimura; T Nakayama; Toshikiro Kimura
Regional variation in oral mucosal drug absorption: permeability and degree of keratinization in hamster oral cavity.
Pharmaceutical research 1991;8(10):1297-301.
1990: T Yamao; S Nakayama; Y Kurosaki; T Nakayama; Toshikiro Kimura
Analysis of hepatic transport of cefpiramide in rats with obstructive jaundice by using isolated hepatocytes.
Pharmaceutical research 1990;7(10):1038-41.
1990: C Li; S Nakayama; Y Kurosaki; T Nakayama; Toshikiro Kimura
Pharmacokinetics of cefpiramide in rats acutely intoxicated with carbon tetrachloride.
Journal of pharmacobio-dynamics 1990;13(3):186-94.
1989: E Fukui; H Tabuchi; Y Kurosaki; T Nakayama; Toshikiro Kimura
Further investigations of enhancing effect of medium-chain triglycerides on d-alpha-tocopherol acetate absorption from lecithin-dispersed preparations in rat small intestine.
Journal of pharmacobio-dynamics 1989;12(12):754-61.
1989: E Fukui; H Kurohara; A Kageyu; Y Kurosaki; T Nakayama; Toshikiro Kimura
Enhancing effect of medium-chain triglycerides on intestinal absorption of d-alpha-tocopherol acetate from lecithin-dispersed preparations in the rat.
Journal of pharmacobio-dynamics 1989;12(2):80-6.
1989: Toshikiro Kimura; K Takeda; A Kageyu; M Toda; Y Kurosaki; T Nakayama
Intestinal absorption of dolichol from emulsions and liposomes in rats.
Chemical & pharmaceutical bulletin 1989;37(2):463-6.
1989: Toshikiro Kimura; E Fukui; A Kageyu; H Kurohara; Y Kurosaki; T Nakayama; Y Morita; K Shibusawa; S Ohsawa; Y Takeda
Enhancement of oral bioavailability of d-alpha-tocopherol acetate by lecithin-dispersed aqueous preparation containing medium-chain triglycerides in rats.
Chemical & pharmaceutical bulletin 1989;37(2):439-41.
1988: Toshikiro Kimura; T Yamao; S Nakayama; S Honge; T Kawakami; Y Kurosaki; T Nakayama
Pharmacokinetics of cefpiramide in rats with obstructive jaundice.
Journal of pharmacobio-dynamics 1988;11(12):839-48.
1988: Y Kurosaki; T Takatori; M Kitayama; T Nakayama; Toshikiro Kimura
Application of propranolol to the keratinized oral mucosa: avoidance of first-pass elimination and the use of 1-dodecylazacycloheptan-2-one (Azone) as an absorption enhancer of bioadhesive film-dosage form.
Journal of pharmacobio-dynamics 1988;11(12):824-32.
1987: Y Kurosaki; S Hisaichi; C Hamada; T Nakayama; Toshikiro Kimura
Studies on drug absorption from oral cavity. II. Influence of the unstirred water layer on absorption from hamster cheek pouch in vitro and in vivo.
Journal of pharmacobio-dynamics 1987;10(4):180-7.