George King

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Geraldes Pedro; Hiraoka-Yamamoto Junko; Matsumoto Motonobu; Clermont Allen; Leitges Michael; Marette Andre; Aiello Lloyd P; Kern Timothy S; King George L
Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy.
Isshiki Keiji; He Zhiheng; Maeno Yasuhiro; Ma Ronald C; Yasuda Yutaka; Kuroki Tatsuya; White Gregory S; Patti Mary E; Weir Gordon C; King George L
Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells.
Geraldes Pedro; Yagi Kunimasa; Ohshiro Yuzuru; He Zhiheng; Maeno Yasuhiro; Yamamoto-Hiraoka Junko; Rask-Madsen Christian; Chung Su Wol; Perrella Mark A; King George L
Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway.

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All Publications

2009: Geraldes Pedro; Hiraoka-Yamamoto Junko; Matsumoto Motonobu; Clermont Allen; Leitges Michael; Marette Andre; Aiello Lloyd P; Kern Timothy S; King George L
Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy.
Nature medicine 2009;15(11):1298-306.
2008: Isshiki Keiji; He Zhiheng; Maeno Yasuhiro; Ma Ronald C; Yasuda Yutaka; Kuroki Tatsuya; White Gregory S; Patti Mary E; Weir Gordon C; King George L
Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells.
Kidney international 2008;74(11):1434-43.
2008: Geraldes Pedro; Yagi Kunimasa; Ohshiro Yuzuru; He Zhiheng; Maeno Yasuhiro; Yamamoto-Hiraoka Junko; Rask-Madsen Christian; Chung Su Wol; Perrella Mark A; King George L
Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway.
The Journal of biological chemistry 2008;283(49):34327-36.
2008: Rask-Madsen Christian; King George L
Differential regulation of VEGF signaling by PKC-alpha and PKC-epsilon in endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(5):919-24.
2008: Rask-Madsen Christian; King George L
More sugar, less blood vessels: another piece in the puzzle of increased cardiovascular risk in diabetes.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(4):608-10.
2008: Biddinger Sudha B; Hernandez-Ono Antonio; Rask-Madsen Christian; Haas Joel T; Alemán José O; Suzuki Ryo; Scapa Erez F; Agarwal Chhavi; Carey Martin C; Stephanopoulos Gregory; Cohen David E; King George L; Ginsberg Henry N; Kahn C Ronald
Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis.
Cell metabolism 2008;7(2):125-34.
2007: Geraldes Pedro; Yamagata Michiko; Rook Susan L; Sassa Yukio; Ma Ronald C; Clermont Allen; Gao Benbo; Aiello Lloyd Paul; Feener Edward P; King George L
Glypican 4, a membrane binding protein for bactericidal/permeability-increasing protein signaling pathways in retinal pigment epithelial cells.
Investigative ophthalmology & visual science 2007;48(12):5750-5.
2007: Noh H; King G L
The role of protein kinase C activation in diabetic nephropathy.
Kidney international. Supplement 2007;(106):S49-53.
2007: Xu Gang; Kaneto Hideaki; Laybutt D Ross; Duvivier-Kali Valerie F; Trivedi Nitin; Suzuma Kiyoshi; King George L; Weir Gordon C; Bonner-Weir Susan
Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes.
Diabetes 2007;56(6):1551-8.
2007: Arikawa Emi; Ma Ronald C W; Isshiki Keiji; Luptak Ivan; He Zhiheng; Yasuda Yutaka; Maeno Yasuhiro; Patti Mary Elizabeth; Weir Gordon C; Harris Robert A; Zammit Victor A; Tian Rong; King George L
Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats.
Diabetes 2007;56(5):1410-20.
2007: Rask-Madsen Christian; King George L
Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes.
Nature clinical practice. Endocrinology & metabolism 2007;3(1):46-56.
2006: Ohshiro Yuzuru; Ma Ronald C; Yasuda Yutaka; Hiraoka-Yamamoto Junko; Clermont Allen C; Isshiki Keiji; Yagi Kunimasa; Arikawa Emi; Kern Timothy S; King George L
Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice.
Diabetes 2006;55(11):3112-20.
2006: Yamagata Michiko; Rook Susan L; Sassa Yukio; Ma Ronald C; Geraldes Pedro; Goddard Lucy; Clermont Allen; Gao Benbo; Salti Haytham; Gundel Robert; White Mark; Feener Edward P; Aiello Lloyd Paul; King George L
Bactericidal/permeability-increasing protein's signaling pathways and its retinal trophic and anti-angiogenic effects.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):2058-67.
2006: Sotiropoulos Konstantinos B; Clermont Allen; Yasuda Yutaka; Rask-Madsen Christian; Mastumoto Motonobu; Takahashi Junichi; Della Vecchia Kim; Kondo Tatsuya; Aiello Lloyd P; King George L
Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPARgamma agonist's effects on edema and weight gain.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(8):1203-5.
2006: He Zhiheng; Opland Darren M; Way Kerrie J; Ueki Kohjiro; Bodyak Natalya; Kang Peter M; Izumo Seigo; Kulkarni Rohit N; Wang Bo; Liao Ronglih; Kahn C Ronald; King George L
Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(4):787-93.
2006: Naruse Keiko; Rask-Madsen Christian; Takahara Noriko; Ha Sung-woo; Suzuma Kiyoshi; Way Kerrie J; Jacobs Judith R C; Clermont Allen C; Ueki Kohjiro; Ohshiro Yuzuru; Zhang Junqing; Goldfine Allison B; King George L
Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance.
Diabetes 2006;55(3):691-8.
2005: Ahmad Fatima K; He Zhiheng; King George L
Molecular targets of diabetic cardiovascular complications.
Current drug targets 2005;6(4):487-94.
2005: Xu Yizhen; He Zhiheng; King George L
Introduction of hyperglycemia and dyslipidemia in the pathogenesis of diabetic vascular complications.
Current diabetes reports 2005;5(2):91-7.
2005: He Zhiheng; Way Kerrie J; Arikawa Emi; Chou Eva; Opland Darren M; Clermont Allen; Isshiki Keiji; Ma Ronald C W; Scott Joshua A; Schoen Frederick J; Feener Edward P; King George L
Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium.
The Journal of biological chemistry 2005;280(16):15719-26.
2005: Rask-Madsen Christian; King George L
Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(3):487-96.
2004: Scott Joshua A; King George L
Oxidative stress and antioxidant treatment in diabetes.
Annals of the New York Academy of Sciences 2004;1031():204-13.
2004: King George L; Loeken Mary R
Hyperglycemia-induced oxidative stress in diabetic complications.
Histochemistry and cell biology 2004;122(4):333-8.
2004: He Zhiheng; King George L
Microvascular complications of diabetes.
Endocrinology and metabolism clinics of North America 2004;33(1):215-38, xi-xii.
2004: Fong Donald S; Aiello Lloyd; Gardner Thomas W; King George L; Blankenship George; Cavallerano Jerry D; Ferris Fredrick L; Klein Ronald;
Retinopathy in diabetes.
Diabetes care 2004;27 Suppl 1():S84-7.
2003: Kuroki Tatsuya; Isshiki Keiji; King George L
Oxidative stress: the lead or supporting actor in the pathogenesis of diabetic complications.
Journal of the American Society of Nephrology : JASN 2003;14(8 Suppl 3):S216-20.
2003: Jiang Zhen Y; He Zhiheng; King Benjamin L; Kuroki Tatsuya; Opland Darren M; Suzuma Kiyoshi; Suzuma Izumi; Ueki Kohjiro; Kulkarni Rohit N; Kahn C Ronald; King George L
Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis.
The Journal of biological chemistry 2003;278(34):31964-71.
2003: Kondo Tatsuya; Vicent David; Suzuma Kiyoshi; Yanagisawa Masashi; King George L; Holzenberger Martin; Kahn C Ronald
Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization.
The Journal of clinical investigation 2003;111(12):1835-42.
2003: Vicent David; Ilany Jacob; Kondo Tatsuya; Naruse Keiko; Fisher Simon J; Kisanuki Yaz Y; Bursell Sven; Yanagisawa Masashi; King George L; Kahn C Ronald
The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance.
The Journal of clinical investigation 2003;111(9):1373-80.
2003: Yokota Tamotsu; Ma Ronald C; Park Joong-Yeol; Isshiki Keiji; Sotiropoulos Konstantinos B; Rauniyar Ravi K; Bornfeldt Karin E; King George L
Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes.
Diabetes 2003;52(3):838-45.
2003: Abiko Toru; Abiko Atsuko; Clermont Allen C; Shoelson Brett; Horio Naoichi; Takahashi Junichi; Adamis Anthony P; King George L; Bursell Sven-Erik
Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation.
Diabetes 2003;52(3):829-37.
2003: Fong Donald S; Aiello Lloyd; Gardner Thomas W; King George L; Blankenship George; Cavallerano Jerry D; Ferris Fredrick L; Klein Ronald;
Diabetic retinopathy.
Diabetes care 2003;26(1):226-9.
2003: Fong Donald S; Aiello Lloyd; Gardner Thomas W; King George L; Blankenship George; Cavallerano Jerry D; Ferris Fredrick L; Klein Ronald;
Diabetic retinopathy.
Diabetes care 2003;26 Suppl 1():S99-S102.
2003: Shen Garry X; Way Kerrie J; Jacobs Judith R C; King George L
Applications of inhibitors for protein kinase C and their isoforms.
Methods in molecular biology (Clifton, N.J.) 2003;233():397-422.
2002: Hiramatsu Yuji; Sekiguchi Naotaka; Hayashi Michio; Isshiki Keiji; Yokota Tamotsu; King George L; Loeken Mary R
Diacylglycerol production and protein kinase C activity are increased in a mouse model of diabetic embryopathy.
Diabetes 2002;51(9):2804-10.
2002: Way Kerrie J; Isshiki Keiji; Suzuma Kiyoshi; Yokota Tamotsu; Zvagelsky Dmitriy; Schoen Frederick J; Sandusky George E; Pechous Penelope A; Vlahos Chris J; Wakasaki Hisao; King George L
Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes.
Diabetes 2002;51(9):2709-18.
2002: Rauniyar Ravi K; Suzuma Kiyoshi; King Adam L; Aiello Lloyd Paul; King George L
Differential effects of bactericidal/permeability-increasing protein (BPI) analogues on retinal neovascularization and retinal pericyte growth.
Investigative ophthalmology & visual science 2002;43(2):503-9.
2002: Suzuma Kiyoshi; Takahara Noriko; Suzuma Izumi; Isshiki Keiji; Ueki Kohjiro; Leitges Michael; Aiello Lloyd Paul; King George L
Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):721-6.
2002: Chou Eva; Suzuma Izumi; Way Kerrie J; Opland Darren; Clermont Allen C; Naruse Keiko; Suzuma Kiyoshi; Bowling Nancy L; Vlahos Chris J; Aiello Lloyd Paul; King George L
Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue.
Circulation 2002;105(3):373-9.
2002: Suzuma Izumi; Suzuma Kiyoshi; Ueki Kohjiro; Hata Yasuaki; Feener Edward P; King George L; Aiello Lloyd Paul
Stretch-induced retinal vascular endothelial growth factor expression is mediated by phosphatidylinositol 3-kinase and protein kinase C (PKC)-zeta but not by stretch-induced ERK1/2, Akt, Ras, or classical/novel PKC pathways.
The Journal of biological chemistry 2002;277(2):1047-57.
2001: Way K J; Katai N; King G L
Protein kinase C and the development of diabetic vascular complications.
Diabetic medicine : a journal of the British Diabetic Association 2001;18(12):945-59.
2001: Meier M; King G L; Clermont A; Perez A; Hayashi M; Feener E P
Angiotensin AT(1) receptor stimulates heat shock protein 27 phosphorylation in vitro and in vivo.
Hypertension 2001;38(6):1260-5.
2000: Suzuma K; Naruse K; Suzuma I; Takahara N; Ueki K; Aiello L P; King G L
Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal vascular cells.
The Journal of biological chemistry 2000;275(52):40725-31.
2000: Mori F; King G L; Clermont A C; Bursell D K; Bursell S E
Endothelin-3 regulation of retinal hemodynamics in nondiabetic and diabetic rats.
Investigative ophthalmology & visual science 2000;41(12):3955-62.
2000: Park J Y; Takahara N; Gabriele A; Chou E; Naruse K; Suzuma K; Yamauchi T; Ha S W; Meier M; Rhodes C J; King G L
Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation.
Diabetes 2000;49(7):1239-48.
2000: Way K J; Chou E; King G L
Identification of PKC-isoform-specific biological actions using pharmacological approaches.
Trends in pharmacological sciences 2000;21(5):181-7.
2000: Koya D; Haneda M; Nakagawa H; Isshiki K; Sato H; Maeda S; Sugimoto T; Yasuda H; Kashiwagi A; Ways D K; King G L; Kikkawa R
Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(3):439-47.
2000: Kuboki K; Jiang Z Y; Takahara N; Ha S W; Igarashi M; Yamauchi T; Feener E P; Herbert T P; Rhodes C J; King G L
Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.
Circulation 2000;101(6):676-81.
1999: Koya D; Dennis J W; Warren C E; Takahara N; Schoen F J; Nishio Y; Nakajima T; Lipes M A; King G L
Overexpression of core 2 N-acetylglycosaminyltransferase enhances cytokine actions and induces hypertrophic myocardium in transgenic mice.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(15):2329-37.
1999: Lee I K; Koya D; Ishi H; Kanoh H; King G L
d-Alpha-tocopherol prevents the hyperglycemia induced activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway in vascular smooth muscle cell by an increase of DAG kinase activity.
Diabetes research and clinical practice 1999;45(2-3):183-90.
1999: Jiang Z Y; Lin Y W; Clemont A; Feener E P; Hein K D; Igarashi M; Yamauchi T; White M F; King G L
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats.
The Journal of clinical investigation 1999;104(4):447-57.
1999: Jiang Z Y; Zhou Q L; Chatterjee A; Feener E P; Myers M G; White M F; King G L
Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells.
Diabetes 1999;48(5):1120-30.
1999: King G L; Wakasaki H
Theoretical mechanisms by which hyperglycemia and insulin resistance could cause cardiovascular diseases in diabetes.
Diabetes care 1999;22 Suppl 3():C31-7.
1999: Bowling N; Walsh R A; Song G; Estridge T; Sandusky G E; Fouts R L; Mintze K; Pickard T; Roden R; Bristow M R; Sabbah H N; Mizrahi J L; Gromo G; King G L; Vlahos C J
Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart.
Circulation 1999;99(3):384-91.
1999: Igarashi M; Wakasaki H; Takahara N; Ishii H; Jiang Z Y; Yamauchi T; Kuboki K; Meier M; Rhodes C J; King G L
Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways.
The Journal of clinical investigation 1999;103(2):185-95.
1999: Park J Y; Ha S W; King G L
The role of protein kinase C activation in the pathogenesis of diabetic vascular complications.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 1999;19 Suppl 2():S222-7.
1998: Takagi H; King G L; Aiello L P
Hypoxia upregulates glucose transport activity through an adenosine-mediated increase of GLUT1 expression in retinal capillary endothelial cells.
Diabetes 1998;47(9):1480-8.
1998: Takeishi Y; Chu G; Kirkpatrick D M; Li Z; Wakasaki H; Kranias E G; King G L; Walsh R A
In vivo phosphorylation of cardiac troponin I by protein kinase Cbeta2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts.
The Journal of clinical investigation 1998;102(1):72-8.
1998: Koya D; King G L
Protein kinase C activation and the development of diabetic complications.
Diabetes 1998;47(6):859-66.
1998: Aiello L P; Gardner T W; King G L; Blankenship G; Cavallerano J D; Ferris F L; Klein R
Diabetic retinopathy.
Diabetes care 1998;21(1):143-56.
1998: Ishii H; Koya D; King G L
Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus.
Journal of molecular medicine (Berlin, Germany) 1998;76(1):21-31.
1998: Koya D; Haneda M; Kikkawa R; King G L
d-alpha-tocopherol treatment prevents glomerular dysfunctions in diabetic rats through inhibition of protein kinase C-diacylglycerol pathway.
BioFactors (Oxford, England) 1998;7(1-2):69-76.
1997: Aiello L P; Bursell S E; Clermont A; Duh E; Ishii H; Takagi C; Mori F; Ciulla T A; Ways K; Jirousek M; Smith L E; King G L
Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor.
Diabetes 1997;46(9):1473-80.
1997: King G L; Ishii H; Koya D
Diabetic vascular dysfunctions: a model of excessive activation of protein kinase C.
Kidney international. Supplement 1997;60():S77-85.
1997: Wakasaki H; Koya D; Schoen F J; Jirousek M R; Ways D K; Hoit B D; Walsh R A; King G L
Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9320-5.
1997: Koya D; Jirousek M R; Lin Y W; Ishii H; Kuboki K; King G L
Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats.
The Journal of clinical investigation 1997;100(1):115-26.
1997: Koya D; Lee I K; Ishii H; Kanoh H; King G L
Prevention of glomerular dysfunction in diabetic rats by treatment with d-alpha-tocopherol.
Journal of the American Society of Nephrology : JASN 1997;8(3):426-35.
1996: Takagi C; Bursell S E; Lin Y W; Takagi H; Duh E; Jiang Z; Clermont A C; King G L
Regulation of retinal hemodynamics in diabetic rats by increased expression and action of endothelin-1.
Investigative ophthalmology & visual science 1996;37(12):2504-18.
1996: Xia P; Aiello L P; Ishii H; Jiang Z Y; Park D J; Robinson G S; Takagi H; Newsome W P; Jirousek M R; King G L
Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth.
The Journal of clinical investigation 1996;98(9):2018-26.
1996: Takagi H; King G L; Robinson G S; Ferrara N; Aiello L P
Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells.
Investigative ophthalmology & visual science 1996;37(11):2165-76.
1996: Takagi C; King G L; Takagi H; Lin Y W; Clermont A C; Bursell S E
Endothelin-1 action via endothelin receptors is a primary mechanism modulating retinal circulatory response to hyperoxia.
Investigative ophthalmology & visual science 1996;37(10):2099-109.
1996: Takagi H; King G L; Aiello L P
Identification and characterization of vascular endothelial growth factor receptor (Flt) in bovine retinal pericytes.
Diabetes 1996;45(8):1016-23.
1996: Kunisaki M; Fumio U; Nawata H; King G L
Vitamin E normalizes diacylglycerol-protein kinase C activation induced by hyperglycemia in rat vascular tissues.
Diabetes 1996;45 Suppl 3():S117-9.
1996: King G L; Kunisaki M; Nishio Y; Inoguchi T; Shiba T; Xia P
Biochemical and molecular mechanisms in the development of diabetic vascular complications.
Diabetes 1996;45 Suppl 3():S105-8.
1996: Ishii H; Jirousek M R; Koya D; Takagi C; Xia P; Clermont A; Bursell S E; Kern T S; Ballas L M; Heath W F; Stramm L E; Feener E P; King G L
Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor.
Science (New York, N.Y.) 1996;272(5262):728-31.
1996: Feener E P; Xia P; Inoguchi T; Shiba T; Kunisaki M; King G L
Role of protein kinase C in glucose- and angiotensin II-induced plasminogen activator inhibitor expression.
Contributions to nephrology 1996;118():180-7.
1995: Nishio Y; Warren C E; Buczek-Thomas J A; Rulfs J; Koya D; Aiello L P; Feener E P; Miller T B; Dennis J W; King G L
Identification and characterization of a gene regulating enzymatic glycosylation which is induced by diabetes and hyperglycemia specifically in rat cardiac tissue.
The Journal of clinical investigation 1995;96(4):1759-67.
1995: Takagi C; King G L; Clermont A C; Cummins D R; Takagi H; Bursell S E
Reversal of abnormal retinal hemodynamics in diabetic rats by acarbose, an alpha-glucosidase inhibitor.
Current eye research 1995;14(9):741-9.
1995: Kunisaki M; Bursell S E; Clermont A C; Ishii H; Ballas L M; Jirousek M R; Umeda F; Nawata H; King G L
Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway.
The American journal of physiology 1995;269(2 Pt 1):E239-46.
1995: Xia P; Kramer R M; King G L
Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2.
The Journal of clinical investigation 1995;96(2):733-40.
1995: Bursell S E; Clermont A C; Oren B; King G L
The in vivo effect of endothelins on retinal circulation in nondiabetic and diabetic rats.
Investigative ophthalmology & visual science 1995;36(3):596-607.
1995: Feener E P; Northrup J M; Aiello L P; King G L
Angiotensin II induces plasminogen activator inhibitor-1 and -2 expression in vascular endothelial and smooth muscle cells.
The Journal of clinical investigation 1995;95(3):1353-62.
1995: Thieme H; Aiello L P; Takagi H; Ferrara N; King G L
Comparative analysis of vascular endothelial growth factor receptors on retinal and aortic vascular endothelial cells.
Diabetes 1995;44(1):98-103.
1994: Kunisaki M; Bursell S E; Umeda F; Nawata H; King G L
Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels.
Diabetes 1994;43(11):1372-7.
1994: Feener E P; Shiba T; Hu K Q; Wilden P A; White M F; King G L
Characterization of phorbol ester-stimulated serine phosphorylation of the human insulin receptor.
The Biochemical journal 1994;303 ( Pt 1)():43-50.
1994: Xia P; Inoguchi T; Kern T S; Engerman R L; Oates P J; King G L
Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia.
Diabetes 1994;43(9):1122-9.
1994: Inoguchi T; Xia P; Kunisaki M; Higashi S; Feener E P; King G L
Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues.
The American journal of physiology 1994;267(3 Pt 1):E369-79.
1994: Aiello L P; Robinson G S; Lin Y W; Nishio Y; King G L
Identification of multiple genes in bovine retinal pericytes altered by exposure to elevated levels of glucose by using mRNA differential display.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(13):6231-5.
1994: Clermont A C; Brittis M; Shiba T; McGovern T; King G L; Bursell S E
Normalization of retinal blood flow in diabetic rats with primary intervention using insulin pumps.
Investigative ophthalmology & visual science 1994;35(3):981-90.
1994: Nishio Y; Aiello L P; King G L
Glucose induced genes in bovine aortic smooth muscle cells identified by mRNA differential display.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1994;8(1):103-6.
1994: King G L; Shiba T; Oliver J; Inoguchi T; Bursell S E
Cellular and molecular abnormalities in the vascular endothelium of diabetes mellitus.
Annual review of medicine 1994;45():179-88.
1993: Shiba T; Inoguchi T; Sportsman J R; Heath W F; Bursell S; King G L
Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation.
The American journal of physiology 1993;265(5 Pt 1):E783-93.
1993: Ohashi H; Rosen K M; Smith F E; Villa-Komaroff L; Nayak R C; King G L
Characterization of type I IGF receptor and IGF-I mRNA expression in cultured human and bovine glomerular cells.
Regulatory peptides 1993;48(1-2):9-20.
1993: Feener E P; Backer J M; King G L; Wilden P A; Sun X J; Kahn C R; White M F
Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor.
The Journal of biological chemistry 1993;268(15):11256-64.
1992: de la Rubia G; Oliver F J; Inoguchi T; King G L
Induction of resistance to endothelin-1's biochemical actions by elevated glucose levels in retinal pericytes.
Diabetes 1992;41(12):1533-9.
1992: Inoguchi T; Battan R; Handler E; Sportsman J R; Heath W; King G L
Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):11059-63.
1992: Nayak R C; Attawia M A; Cahill C J; King G L; Ohashi H; Moromisato R
Expression of a monoclonal antibody (3G5) defined ganglioside antigen in the renal cortex.
Kidney international 1992;41(6):1638-45.
1992: Bursell S E; Clermont A C; Shiba T; King G L
Evaluating retinal circulation using video fluorescein angiography in control and diabetic rats.
Current eye research 1992;11(4):287-95.
1991: Oliver F J; de la Rubia G; Feener E P; Lee M E; Loeken M R; Shiba T; Quertermous T; King G L
Stimulation of endothelin-1 gene expression by insulin in endothelial cells.
The Journal of biological chemistry 1991;266(34):23251-6.
1991: Lee T S; Hu K Q; Chao T; King G L
Characterization of endothelin receptors and effects of endothelin on diacylglycerol and protein kinase C in retinal capillary pericytes.
Diabetes 1991;40(11):1564.
1991: King G L; Ohashi H; Najak R
A cell biology approach to the study of diabetic vascular complications.
The Journal of diabetic complications 1991;5(2-3):56-7.
1990: Hu K Q; Backer J M; Sahagian G; Feener E P; King G L
Modulation of the insulin growth factor II/mannose 6-phosphate receptor in microvascular endothelial cells by phorbol ester via protein kinase C.
The Journal of biological chemistry 1990;265(23):13864-70.
1989: Lee T S; Hu K Q; Chao T; King G L
Characterization of endothelin receptors and effects of endothelin on diacylglycerol and protein kinase C in retinal capillary pericytes.
Diabetes 1989;38(12):1643-6.
1989: Banskota N K; Taub R; Zellner K; King G L
Insulin, insulin-like growth factor I and platelet-derived growth factor interact additively in the induction of the protooncogene c-myc and cellular proliferation in cultured bovine aortic smooth muscle cells.
Molecular endocrinology (Baltimore, Md.) 1989;3(8):1183-90.
1989: Lee T S; Saltsman K A; Ohashi H; King G L
Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(13):5141-5.
1989: Lee T S; Chao T; Hu K Q; King G L
Endothelin stimulates a sustained 1,2-diacylglycerol increase and protein kinase C activation in bovine aortic smooth muscle cells.
Biochemical and biophysical research communications 1989;162(1):381-6.
1989: Bottaro D P; Bonner-Weir S; King G L
Insulin receptor recycling in vascular endothelial cells. Regulation by insulin and phorbol ester.
The Journal of biological chemistry 1989;264(10):5916-23.
1989: Kwok C F; Goldstein B J; Muller-Wieland D; Lee T S; Kahn C R; King G L
Identification of persistent defects in insulin receptor structure and function capillary endothelial cells from diabetic rats.
The Journal of clinical investigation 1989;83(1):127-36.
1989: Lee T S; MacGregor L C; Fluharty S J; King G L
Differential regulation of protein kinase C and (Na,K)-adenosine triphosphatase activities by elevated glucose levels in retinal capillary endothelial cells.
The Journal of clinical investigation 1989;83(1):90-4.
1989: Banskota N K; Taub R; Zellner K; Olsen P; King G L
Characterization of induction of protooncogene c-myc and cellular growth in human vascular smooth muscle cells by insulin and IGF-I.
Diabetes 1989;38(1):123-9.
1988: Hachiya H L; Halban P A; King G L
Intracellular pathways of insulin transport across vascular endothelial cells.
The American journal of physiology 1988;255(4 Pt 1):C459-64.
1988: Nayak R C; Berman A B; George K L; Eisenbarth G S; King G L
A monoclonal antibody (3G5)-defined ganglioside antigen is expressed on the cell surface of microvascular pericytes.
The Journal of experimental medicine 1988;167(3):1003-15.
1988: Arnqvist H J; Ballermann B J; King G L
Receptors for and effects of insulin and IGF-I in rat glomerular mesangial cells.
The American journal of physiology 1988;254(3 Pt 1):C411-6.
1987: King G L; Berman A B; Bonner-Weir S; Carson M P
Regulation of vascular permeability in cell culture.
Diabetes 1987;36(12):1460-7.

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