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Paul Bajaj

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Kanagasabai Vadivel; Sayeh Agah; Madhu S Bajaj; Duilio Cascio; Charles T Esmon; Sriram Krishnaswamy; Amanda S Messer; Kaillathe Padmanabhan; S Paul Bajaj
Structural and Functional Studies of γ-Carboxyglutamic Acid Domains of Factor VIIa and Activated Protein C: Role of Magnesium at Physiological Calcium.
Yipeng Geng; Amanda Messer; Stephen B Smith; Mao-Fu Sun; Ingrid Verhamme; S Paul Bajaj; David Gailani
A sequential mechanism for exosite-mediated factor IX activation by factor XIa.
Kanagasabai Vadivel; S Paul Bajaj
Structural biology of factor VIIa/tissue factor initiated coagulation.

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All Publications

2013: Kanagasabai Vadivel; Sayeh Agah; Madhu S Bajaj; Duilio Cascio; Charles T Esmon; Sriram Krishnaswamy; Amanda S Messer; Kaillathe Padmanabhan; S Paul Bajaj
Structural and Functional Studies of γ-Carboxyglutamic Acid Domains of Factor VIIa and Activated Protein C: Role of Magnesium at Physiological Calcium.
Journal of molecular biology 2013;425(11):1961-81.
2012: Yipeng Geng; Amanda Messer; Stephen B Smith; Mao-Fu Sun; Ingrid Verhamme; S Paul Bajaj; David Gailani
A sequential mechanism for exosite-mediated factor IX activation by factor XIa.
The Journal of biological chemistry 2012;287(45):38200-9.
2012: Kanagasabai Vadivel; S Paul Bajaj
Structural biology of factor VIIa/tissue factor initiated coagulation.
Frontiers in bioscience : a journal and virtual library 2012;17():2476-94.
2008: Amy E Schmidt; Mao-Fu Sun; Taketoshi Ogawa; S Paul Bajaj; David Gailani
Functional role of residue 193 (chymotrypsin numbering) in serine proteases: influence of side chain length and beta-branching on the catalytic activity of blood coagulation factor XIa.
Biochemistry 2008;47(5):1326-35.
2007: Madhu S Bajaj; M Ghosh; S Paul Bajaj
Fibronectin-adherent monocytes express tissue factor and tissue factor pathway inhibitor whereas endotoxin-stimulated monocytes primarily express tissue factor: physiologic and pathologic implications.
Journal of thrombosis and haemostasis : JTH 2007;5(7):1493-9.
2007: Matthew Ndonwi; George J Broze; Sayeh Agah; Amy E Schmidt; S Paul Bajaj
Substitution of the Gla domain in factor X with that of protein C impairs its interaction with factor VIIa/tissue factor: lack of comparable effect by similar substitution in factor IX.
The Journal of biological chemistry 2007;282(21):15632-44.
2006: S Paul Bajaj; Amy E Schmidt; Sayeh Agah; Madhu S Bajaj; Kaillathe Padmanabhan
High resolution structures of p-aminobenzamidine- and benzamidine-VIIa/soluble tissue factor: unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+, and Zn2+ sites in factor VIIa.
The Journal of biological chemistry 2006;281(34):24873-88.
2005: Amy E Schmidt; Hitendra S Chand; Duilio Cascio; Walter Kisiel; S Paul Bajaj
Crystal structure of Kunitz domain 1 (KD1) of tissue factor pathway inhibitor-2 in complex with trypsin. Implications for KD1 specificity of inhibition.
The Journal of biological chemistry 2005;280(30):27832-8.
2005: Amy E Schmidt; Jonathan E Stewart; Akash Mathur; Senthil Kumar Krishnaswamy; S Paul Bajaj
Na+ site in blood coagulation factor IXa: effect on catalysis and factor VIIIa binding.
Journal of molecular biology 2005;350(1):78-91.
2005: M Ndonwi; George J Broze; S Paul Bajaj
The first epidermal growth factor-like domains of factor Xa and factor IXa are important for the activation of the factor VII--tissue factor complex.
Journal of thrombosis and haemostasis : JTH 2005;3(1):112-8.
2004: Amy E Schmidt; Taketoshi Ogawa; David Gailani; S Paul Bajaj
Structural role of Gly(193) in serine proteases: investigations of a G555E (GLY193 in chymotrypsin) mutant of blood coagulation factor XI.
The Journal of biological chemistry 2004;279(28):29485-92.
2004: Hitendra S Chand; Amy E Schmidt; S Paul Bajaj; Walter Kisiel
Structure-function analysis of the reactive site in the first Kunitz-type domain of human tissue factor pathway inhibitor-2.
The Journal of biological chemistry 2004;279(17):17500-7.
2003: Amy E Schmidt; S Paul Bajaj
Structure-function relationships in factor IX and factor IXa.
Trends in cardiovascular medicine 2003;13(1):39-45.
2002: Amy E Schmidt; Kaillathe Padmanabhan; Matthew C Underwood; Wolfram Bode; Timothy Mather; S Paul Bajaj
Thermodynamic linkage between the S1 site, the Na+ site, and the Ca2+ site in the protease domain of human activated protein C (APC). Sodium ion in the APC crystal structure is coordinated to four carbonyl groups from two separate loops.
The Journal of biological chemistry 2002;277(32):28987-95.
2002: Degang Zhong; Madhu S Bajaj; Amy E Schmidt; S Paul Bajaj
The N-terminal epidermal growth factor-like domain in factor IX and factor X represents an important recognition motif for binding to tissue factor.
The Journal of biological chemistry 2002;277(5):3622-31.
2001: Madhu S Bajaj; Jens Birktoft; Sarah A Steer; S Paul Bajaj
Structure and biology of tissue factor pathway inhibitor.
Thrombosis and haemostasis 2001;86(4):959-72.
2001: S Paul Bajaj; Amy E Schmidt; Akash Mathur; Kaillathe Padmanabhan; D Zhong; Maria Mastri; Philip J Fay
Factor IXa:factor VIIIa interaction. helix 330-338 of factor ixa interacts with residues 558-565 and spatially adjacent regions of the a2 subunit of factor VIIIa.
The Journal of biological chemistry 2001;276(19):16302-9.
1999: Madhu S Bajaj; Sarah A Steer; Mohan Kuppuswamy; W Kisiel; S Paul Bajaj
Synthesis and expression of tissue factor pathway inhibitor by serum-stimulated fibroblasts, vascular smooth muscle cells and cardiac myocytes.
Thrombosis and haemostasis 1999;82(6):1663-72.
1999: Madhu S Bajaj; Mohan Kuppuswamy; Anantha Manepalli; S Paul Bajaj
Transcriptional expression of tissue factor pathway inhibitor, thrombomodulin and von Willebrand factor in normal human tissues.
Thrombosis and haemostasis 1999;82(3):1047-52.
1999: S Paul Bajaj
Region of factor IXa protease domain that interacts with factor VIIIa: analysis of select hemophilia B mutants.
Thrombosis and haemostasis 1999;82(2):218-25.
1999: Akash Mathur; S Paul Bajaj
Protease and EGF1 domains of factor IXa play distinct roles in binding to factor VIIIa. Importance of helix 330 (helix 162 in chymotrypsin) of protease domain of factor IXa in its interaction with factor VIIIa.
The Journal of biological chemistry 1999;274(26):18477-86.
1998: Pamela Sakkinen; Mary Cushman; B M Psaty; Lewis H Kuller; S Paul Bajaj; AK Sabharwal; R Boineau; EM Macy; Russell P Tracy
Correlates of antithrombin, protein C, protein S, and TFPI in a healthy elderly cohort.
Thrombosis and haemostasis 1998;80(1):134-9.
1997: Akash Mathur; D Zhong; AK Sabharwal; Kenneth J Smith; S Paul Bajaj
Interaction of factor IXa with factor VIIIa. Effects of protease domain Ca2+ binding site, proteolysis in the autolysis loop, phospholipid, and factor X.
The Journal of biological chemistry 1997;272(37):23418-26.
1997: AK Sabharwal; Kaillathe Padmanabhan; Alexander Tulinsky; Akash Mathur; J Gorka; S Paul Bajaj
Interaction of calcium with native and decarboxylated human factor X. Effect of proteolysis in the autolysis loop on catalytic efficiency and factor Va binding.
The Journal of biological chemistry 1997;272(35):22037-45.
1997: Madhu S Bajaj; S Paul Bajaj
Tissue factor pathway inhibitor: potential therapeutic applications.
Thrombosis and haemostasis 1997;78(1):471-7.
1995: A K Sabharwal; Jens Birktoft; J Gorka; P Wildgoose; Lars C Petersen; S Paul Bajaj
High affinity Ca(2+)-binding site in the serine protease domain of human factor VIIa and its role in tissue factor binding and development of catalytic activity.
The Journal of biological chemistry 1995;270(26):15523-30.
1995: Bjarne Osterud; Madhu S Bajaj; S Paul Bajaj
Sites of tissue factor pathway inhibitor (TFPI) and tissue factor expression under physiologic and pathologic conditions. On behalf of the Subcommittee on Tissue factor Pathway Inhibitor (TFPI) of the Scientific and Standardization Committee of the ISTH.
Thrombosis and haemostasis 1995;73(5):873-5.
1995: A K Sabharwal; S Paul Bajaj; A Ameri; S M Tricomi; T M Hyers; T E Dahms; F B Taylor; Madhu S Bajaj
Tissue factor pathway inhibitor and von Willebrand factor antigen levels in adult respiratory distress syndrome and in a primate model of sepsis.
American journal of respiratory and critical care medicine 1995;151(3 Pt 1):758-67.
1994: D Zhong; Kenneth J Smith; Jens Birktoft; S Paul Bajaj
First epidermal growth factor-like domain of human blood coagulation factor IX is required for its activation by factor VIIa/tissue factor but not by factor XIa.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3574-8.
1993: D Zhong; S Paul Bajaj
A PCR-based method for site-specific domain replacement that does not require restriction recognition sequences.
BioTechniques 1993;15(5):874-8.
1993: T Anderssen; H Halvorsen; S Paul Bajaj; Bjarne Osterud
Human leukocyte elastase and cathepsin G inactivate factor VII by limited proteolysis.
Thrombosis and haemostasis 1993;70(3):414-7.
1993: D R Tyson; Mohan Kuppuswamy; G J Broze; S Paul Bajaj
Revised DNA sequence of exon 1 and 5' flanking region of the human tissue factor pathway inhibitor gene.
Thrombosis research 1993;70(3):269-73.
1993: Azzaq Belaaouaj; Mohan Kuppuswamy; Jens Birktoft; S Paul Bajaj
Revised cDNA sequence of rabbit tissue factor pathway inhibitor.
Thrombosis research 1993;69(6):547-53.
1993: S Paul Bajaj; Jens Birktoft
Human factor IX and factor IXa.
Methods in enzymology 1993;222():96-128.
1992: A Ameri; Mohan Kuppuswamy; S Basu; S Paul Bajaj
Expression of tissue factor pathway inhibitor by cultured endothelial cells in response to inflammatory mediators.
Blood 1992;79(12):3219-26.
1992: M Ludwig; A K Sabharwal; Hans H Brackmann; K Olek; Kenneth J Smith; Jens Birktoft; S Paul Bajaj
Hemophilia B caused by five different nondeletion mutations in the protease domain of factor IX.
Blood 1992;79(5):1225-32.
1992: S Paul Bajaj; A K Sabharwal; J Gorka; Jens Birktoft
Antibody-probed conformational transitions in the protease domain of human factor IX upon calcium binding and zymogen activation: putative high-affinity Ca(2+)-binding site in the protease domain.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(1):152-6.
1991: Mohan Kuppuswamy; J W Hoffmann; C K Kasper; S G Spitzer; S L Groce; S Paul Bajaj
Single nucleotide primer extension to detect genetic diseases: experimental application to hemophilia B (factor IX) and cystic fibrosis genes.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(4):1143-7.
1990: Madhu S Bajaj; Mohan Kuppuswamy; H Saito; S G Spitzer; S Paul Bajaj
Cultured normal human hepatocytes do not synthesize lipoprotein-associated coagulation inhibitor: evidence that endothelium is the principal site of its synthesis.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(22):8869-73.
1990: S G Spitzer; Mohan Kuppuswamy; R Saini; C K Kasper; Jens Birktoft; S Paul Bajaj
Factor IXHollywood: substitution of Pro55 by Ala in the first epidermal growth factor-like domain.
Blood 1990;76(8):1530-7.
1990: S Paul Bajaj; S G Spitzer; WILLIAM J WELSH; B J Warn-Cramer; C K Kasper; Jens Birktoft
Experimental and theoretical evidence supporting the role of Gly363 in blood coagulation factor IXa (Gly193 in chymotrypsin) for proper activation of the proenzyme.
The Journal of biological chemistry 1990;265(5):2956-61.
1990: S G Spitzer; B J Warn-Cramer; C K Kasper; S Paul Bajaj
Replacement of isoleucine-397 by threonine in the clotting proteinase factor IXa (Los Angeles and Long Beach variants) affects macromolecular catalysis but not L-tosylarginine methyl ester hydrolysis. Lack of correlation between the ox brain prothrombin time and the mutation site in the variant proteins.
The Biochemical journal 1990;265(1):219-25.
1988: S G Spitzer; U R Pendurthi; C K Kasper; S Paul Bajaj
Molecular defect in factor IXBm Lake Elsinore. Substitution of Ala390 by Val in the catalytic domain.
The Journal of biological chemistry 1988;263(22):10545-8.
1988: S Paul Bajaj; R Saini; A Katz; G Z Cai; S L Maki; G L Brodsky
Metal ion blockage of tritium incorporation into gamma-carboxyglutamic acid of prothrombin. Stoichiometry of gamma-carboxyglutamic acid to Gd3+ for the high affinity sites.
The Journal of biological chemistry 1988;263(20):9725-32.
1987: Madhu S Bajaj; S V Rana; R B Wysolmerski; S Paul Bajaj
Inhibitor of the factor VIIa-tissue factor complex is reduced in patients with disseminated intravascular coagulation but not in patients with severe hepatocellular disease.
The Journal of clinical investigation 1987;79(6):1874-8.
1986: B J Warn-Cramer; S Paul Bajaj
Intrinsic versus extrinsic coagulation. Kinetic considerations.
The Biochemical journal 1986;239(3):757-62.
1985: B J Warn-Cramer; S Paul Bajaj
Stoichiometry of binding of high molecular weight kininogen to factor XI/XIa.
Biochemical and biophysical research communications 1985;133(2):417-22.
1985: S Paul Bajaj; S I Rapaport; S L Maki
A monoclonal antibody to factor IX that inhibits the factor VIII:Ca potentiation of factor X activation.
The Journal of biological chemistry 1985;260(21):11574-80.
1985: P Usharani; B J Warn-Cramer; C K Kasper; S Paul Bajaj
Characterization of three abnormal factor IX variants (Bm Lake Elsinore, Long Beach, and Los Angeles) of hemophilia-B. Evidence for defects affecting the latent catalytic site.
The Journal of clinical investigation 1985;75(1):76-83.
1983: S Paul Bajaj; S I Rapaport; S L Maki; S F Brown
A procedure for isolation of human protein C and protein S as by-products of the purification of factors VII, IX, X and prothrombin.
Preparative biochemistry 1983;13(3):191-214.
1981: S Paul Bajaj; S I Rapaport; S F Brown
Isolation and characterization of human factor VII. Activation of factor VII by factor Xa.
The Journal of biological chemistry 1981;256(1):253-9.