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Manjunatha Kini

Research Profile

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Publications

TOP 3
Ryan J R McCleary; R Manjunatha Kini
Non-enzymatic proteins from snake venoms: a gold mine of pharmacological tools and drug leads.
R Manjunatha Kini; Jay W Fox
Milestones and future prospects in snake venom research.
A S Angie Ng; R Manjunatha Kini
Structural determinants in protein folding: a single conserved hydrophobic residue determines folding of EGF domains.

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All Publications

2013: Ryan J R McCleary; R Manjunatha Kini
Non-enzymatic proteins from snake venoms: a gold mine of pharmacological tools and drug leads.
Toxicon : official journal of the International Society on Toxinology 2013;62():56-74.
2013: R Manjunatha Kini; Jay W Fox
Milestones and future prospects in snake venom research.
Toxicon : official journal of the International Society on Toxinology 2013;62():1-2.
2013: A S Angie Ng; R Manjunatha Kini
Structural determinants in protein folding: a single conserved hydrophobic residue determines folding of EGF domains.
ACS chemical biology 2013;8(1):161-9.
2012: Cho Yeow Koh; R Manjunatha Kini
From snake venom toxins to therapeutics--cardiovascular examples.
Toxicon : official journal of the International Society on Toxinology 2012;59(4):497-506.
2012: Vallerinteavide Mavelli Girish; Chacko Jobichen; Lissa Joseph; R Manjunatha Kini; Sundramurthy Kumar; Xingding Zhou
Identification and structural characterization of a new three-finger toxin hemachatoxin from Hemachatus haemachatus venom.
PloS one 2012;7(10):e48112.
2012: Yan Li; Thomas Lisowsky; Nilesh K Mahajan; Donglai Sheng; Chanchal Chandramouli; Muhammad Farooq; Yunhan Hong; R Manjunatha Kini; Tian Lan; Ruowen Ge
Augmenter of liver regeneration (alr) promotes liver outgrowth during zebrafish hepatogenesis.
PloS one 2012;7(1):e30835.
2011: Shifali Tiwari Chatrath; Alex Chapeaurouge; Qingsong Lin; Teck Kwang Lim; Nathan Dunstan; Peter Mirtschin; Prakash P Kumar; R Manjunatha Kini
Identification of novel proteins from the venom of a cryptic snake Drysdalia coronoides by a combined transcriptomics and proteomics approach.
Journal of proteome research 2011;10(2):739-50.
2011: Xingding Zhou; R Manjunatha Kini; Xingding Zhou
Application of isothermal titration calorimetry and column chromatography for identification of biomolecular targets.
Nature protocols 2011;6(2):158-65.
2011: Wei Xiang; He Yang; Yong Zhang; Lang Zhuo; Grace Ho-Yuet Cheng; Ishak Darryl Irwan; Zhiyuan Ke; R Manjunatha Kini; Padma Potturi; Konerirajapuram N Sulochana; Jingyu Wang; Zhengyuan Wang; Ruowen Ge
Isthmin is a novel secreted angiogenesis inhibitor that inhibits tumour growth in mice.
Journal of cellular and molecular medicine 2011;15(2):359-74.
2011: Cho Yeow Koh; Sundramurthy Kumar; Jun Mizuguchi; Patricia A Nuttall; Uvaraj P Radhakrishnan; Kunchithapadam Swaminathan; Takayuki Imamura; Sadaaki Iwanaga; Pudur Jagadeeswaran; Maria Kazimirova; Seongcheol Kim; R Manjunatha Kini
Crystal structure of thrombin in complex with S-variegin: insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors.
PloS one 2011;6(10):e26367.
2011: Y Zhang; M Chen; S Venugopal; Y Zhou; W Xiang; Y-H Li; Q Lin; R Manjunatha Kini; Y-S Chong; Ruowen Ge
Isthmin exerts pro-survival and death-promoting effect on endothelial cells through alphavbeta5 integrin depending on its physical state.
Cell death & disease 2011;2():e153.
2010: R Manjunatha Kini; Robin Doley
Structure, function and evolution of three-finger toxins: mini proteins with multiple targets.
Toxicon : official journal of the International Society on Toxinology 2010;56(6):855-67.
2010: R Manjunatha Kini; Arunkumar Chinnasamy
Nucleotide sequence determines the accelerated rate of point mutations.
Toxicon : official journal of the International Society on Toxinology 2010;56(3):295-304.
2010: G OmPraba; Alex Chapeaurouge; Robin Doley; K Rama Devi; P Padmanaban; C Venkatraman; D Velmurugan; Qingsong Lin; R Manjunatha Kini
Identification of a novel family of snake venom proteins Veficolins from Cerberus rynchops using a venom gland transcriptomics and proteomics approach.
Journal of proteome research 2010;9(4):1882-93.
2010: Amrita Roy; Xingding Zhou; Ming Zhi Chong; Dieter D'hoedt; Chun Shin Foo; Nandhakishore Rajagopalan; Selvanayagam Nirthanan; Daniel Bertrand; Xingding Zhou; R Manjunatha Kini
Structural and functional characterization of a novel homodimeric three-finger neurotoxin from the venom of Ophiophagus hannah (king cobra).
The Journal of biological chemistry 2010;285(11):8302-15.
2010: Cassandra M Modahl; Robin Doley; R Manjunatha Kini
Venom analysis of long-term captive Pakistan cobra (Naja naja) populations.
Toxicon : official journal of the International Society on Toxinology 2010;55(2-3):612-8.
2010: Ang Swee Siang; Robin Doley; Freek J Vonk; R Manjunatha Kini
Transcriptomic analysis of the venom gland of the red-headed krait (Bungarus flaviceps) using expressed sequence tags.
BMC molecular biology 2010;11():24.
2009: Cho Yeow Koh; Maria Kazimirova; Patricia A Nuttall; R Manjunatha Kini
Noncompetitive inhibitor of thrombin.
Chembiochem : a European journal of chemical biology 2009;10(13):2155-8.
2009: Shiyang Kwong; Anthony E Woods; Peter Mirtschin; Ruowen Ge; R Manjunatha Kini
The recruitment of blood coagulation factor X into snake venom gland as a toxin: the role of promoter cis-elements in its expression.
Thrombosis and haemostasis 2009;102(3):469-78.
2009: Cho Yeow Koh; R Manjunatha Kini
Molecular diversity of anticoagulants from haematophagous animals.
Thrombosis and haemostasis 2009;102(3):437-53.
2009: Robin Doley; R Manjunatha Kini
Protein complexes in snake venom.
Cellular and molecular life sciences : CMLS 2009;66(17):2851-71.
2009: Tse Siang Kang; R Manjunatha Kini
Structural determinants of protein folding.
Cellular and molecular life sciences : CMLS 2009;66(14):2341-61.
2009: Joanna Pawlak; Stephen P Mackessy; Nicole M Sixberry; Enrico A Stura; Marie Hélène Le Du; Renée Ménez; Chun Shin Foo; André Ménez; Selvanayagam Nirthanan; R Manjunatha Kini
Irditoxin, a novel covalently linked heterodimeric three-finger toxin with high taxon-specific neurotoxicity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(2):534-45.
2009: Mário T Murakami; R Manjunatha Kini; Raghuvir K Arni
Crystal structure of bucain, a three-fingered toxin from the venom of the Malayan krait (Bungarus candidus).
Protein and peptide letters 2009;16(12):1473-7.
2009: Robin Doley; Stephen P Mackessy; R Manjunatha Kini
Role of accelerated segment switch in exons to alter targeting (ASSET) in the molecular evolution of snake venom proteins.
BMC evolutionary biology 2009;9():146.
2008: Cho Yeow Koh; R Manjunatha Kini
Anticoagulants from hematophagous animals.
Expert review of hematology 2008;1(2):135-9.
2008: K C Ponnappa; Pushpa Saviour; Nallur B Ramachandra; R Manjunatha Kini; T Veerabasappa Gowda
INN-toxin, a highly lethal peptide from the venom of Indian cobra (Naja naja) venom-Isolation, characterization and pharmacological actions.
Peptides 2008;29(11):1893-900.
2008: Xingding Zhou; Qingxiang Sun; R Manjunatha Kini; Xingding Zhou
A universal method for fishing target proteins from mixtures of biomolecules using isothermal titration calorimetry.
Protein science : a publication of the Protein Society 2008;17(10):1798-804.
2008: Xingding Zhou; Tien-Chye Tan; Suresh Valiyaveettil; Mei-Lin Go; R Manjunatha Kini; Adrian Velazquez-Campoy; Xingding Zhou
Structural characterization of myotoxic ecarpholin S from Echis carinatus venom.
Biophysical journal 2008;95(7):3366-80.
2008: Joanna Pawlak; R Manjunatha Kini
Unique gene organization of colubrid three-finger toxins: complete cDNA and gene sequences of denmotoxin, a bird-specific toxin from colubrid snake Boiga dendrophila (Mangrove Catsnake).
Biochimie 2008;90(6):868-77.
2008: Rajamani Lakshminarayanan; Subramanian Vivekanandan; Ramar Perumal Samy; Yajnavalka Banerjee; Emma Ooi Chi-Jin; Kay Wah Teo; Seetharama D S Jois; R Manjunatha Kini; Suresh Valiyaveettil
Structure, self-assembly, and dual role of a beta-defensin-like peptide from the Chinese soft-shelled turtle eggshell matrix.
Journal of the American Chemical Society 2008;130(14):4660-8.
2008: Syed Rehana; R Manjunatha Kini
Complement C3 isoforms in Austrelaps superbus.
Toxicon : official journal of the International Society on Toxinology 2008;51(5):864-81.
2008: Robin Doley; Susanta Pahari; Stephen P Mackessy; R Manjunatha Kini
Accelerated exchange of exon segments in Viperid three-finger toxin genes (Sistrurus catenatus edwardsii; Desert Massasauga).
BMC evolutionary biology 2008;8():196.
2008: Robin Doley; Nguyen Ngoc Bao Tram; Md Abu Reza; R Manjunatha Kini
Unusual accelerated rate of deletions and insertions in toxin genes in the venom glands of the pygmy copperhead (Austrelaps labialis) from Kangaroo island.
BMC evolutionary biology 2008;8():70.
2007: Yajnavalka Banerjee; Rajamani Lakshminarayanan; Subramanian Vivekanandan; Ganesh Srinivasan Anand; Suresh Valiyaveettil; R Manjunatha Kini
Biophysical characterization of anticoagulant hemextin AB complex from the venom of snake Hemachatus haemachatus.
Biophysical journal 2007;93(11):3963-76.
2007: Nandhakishore Rajagopalan; Yuh Fen Pung; Yi-Zhun Zhu; Peter T-H Wong; Prakash P Kumar; R Manjunatha Kini
Beta-cardiotoxin: a new three-finger toxin from Ophiophagus hannah (king cobra) venom with beta-blocker activity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(13):3685-95.
2007: Cho Yeow Koh; Maria Kazimirova; Adama R Trimnell; Peter Takac; Milan Labuda; Patricia A Nuttall; R Manjunatha Kini
Variegin, a novel fast and tight binding thrombin inhibitor from the tropical bont tick.
The Journal of biological chemistry 2007;282(40):29101-13.
2007: Yajnavalka Banerjee; Sundramurthy Kumar; Chacko Jobichen; R Manjunatha Kini
Crystallization and preliminary X-ray diffraction analysis of hemextin A: a unique anticoagulant protein from Hemachatus haemachatus venom.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 8):701-3.
2007: Tse Siang Kang; Zoran Radić; Todd Talley; Palmer Taylor; Seetharama D S Jois; R Manjunatha Kini
Protein folding determinants: structural features determining alternative disulfide pairing in alpha- and chi/lambda-conotoxins.
Biochemistry 2007;46(11):3338-55.
2007: Natalie G Lumsden; Yajnavalka Banerjee; R Manjunatha Kini; Sanjaya Kuruppu; Wayne C Hodgson
Isolation and characterization of rufoxin, a novel protein exhibiting neurotoxicity from venom of the psammophiine, Rhamphiophis oxyrhynchus (Rufous beaked snake).
Neuropharmacology 2007;52(4):1065-70.
2007: Dileep G Nair; Bryan Fry; Paul F Alewood; Prakash P Kumar; R Manjunatha Kini
Antimicrobial activity of omwaprin, a new member of the waprin family of snake venom proteins.
The Biochemical journal 2007;402(1):93-104.
2007: Susanta Pahari; Stephen P Mackessy; R Manjunatha Kini
The venom gland transcriptome of the Desert Massasauga rattlesnake (Sistrurus catenatus edwardsii): towards an understanding of venom composition among advanced snakes (Superfamily Colubroidea).
BMC molecular biology 2007;8():115.
2007: Susanta Pahari; David Bickford; Bryan Fry; R Manjunatha Kini
Expression pattern of three-finger toxin and phospholipase A2 genes in the venom glands of two sea snakes, Lapemis curtus and Acalyptophis peronii: comparison of evolution of these toxins in land snakes, sea kraits and sea snakes.
BMC evolutionary biology 2007;7():175.
2007: Md Abu Reza; Sanjay Swarup; R Manjunatha Kini
Structure of two genes encoding parallel prothrombin activators in Tropidechis carinatus snake: gene duplication and recruitment of factor X gene to the venom gland.
Journal of thrombosis and haemostasis : JTH 2007;5(1):117-26.
2007: Subramanyam Gayathri; Rajamani Lakshminarayanan; James C Weaver; Daniel E Morse; R Manjunatha Kini; Suresh Valiyaveettil
In vitro study of magnesium-calcite biomineralization in the skeletal materials of the seastar Pisaster giganteus.
Chemistry (Weinheim an der Bergstrasse, Germany) 2007;13(11):3262-8.
2006: Rajamani Lakshminarayanan; Xian Jun Loh; Subramanyam Gayathri; Swaminathan Sindhu; Yajnavalka Banerjee; R Manjunatha Kini; Suresh Valiyaveettil
Formation of transient amorphous calcium carbonate precursor in quail eggshell mineralization: an in vitro study.
Biomacromolecules 2006;7(11):3202-9.
2006: Joanna Pawlak; Stephen P Mackessy; Bryan Fry; Madhav Bhatia; Gilles Mourier; Carole Fruchart-Gaillard; Denis Servent; Renée Ménez; Enrico A Stura; André Ménez; R Manjunatha Kini
Denmotoxin, a three-finger toxin from the colubrid snake Boiga dendrophila (Mangrove Catsnake) with bird-specific activity.
The Journal of biological chemistry 2006;281(39):29030-41.
2006: Tse Siang Kang; Seetharama D S Jois; R Manjunatha Kini
Solution structures of two structural isoforms of CMrVIA chi/lambda-conotoxin.
Biomacromolecules 2006;7(8):2337-46.
2006: R Manjunatha Kini
Anticoagulant proteins from snake venoms: structure, function and mechanism.
The Biochemical journal 2006;397(3):377-87.
2006: Yuh Fen Pung; Sanjeed Vijaya Kumar; Nandhakishore Rajagopalan; Bryan Fry; Prakash P Kumar; R Manjunatha Kini
Ohanin, a novel protein from king cobra venom: its cDNA and genomic organization.
Gene 2006;371(2):246-56.
2005: Yajnavalka Banerjee; Jun Mizuguchi; Sadaaki Iwanaga; R Manjunatha Kini
Hemextin AB complex, a unique anticoagulant protein complex from Hemachatus haemachatus (African Ringhals cobra) venom that inhibits clot initiation and factor VIIa activity.
The Journal of biological chemistry 2005;280(52):42601-11.
2005: Sanjaya Kuruppu; Shane Reeve; Yajnavalka Banerjee; R Manjunatha Kini; A Ian Smith; Wayne C Hodgson
Isolation and pharmacological characterization of cannitoxin, a presynaptic neurotoxin from the venom of the Papuan Taipan (Oxyuranus scutellatus canni).
The Journal of pharmacology and experimental therapeutics 2005;315(3):1196-202.
2005: Nivedita Mitra; Sharmistha Sinha; R Manjunatha Kini; Avadhesha Surolia
Analysis of the peanut agglutinin molten globule-like intermediate by limited proteolysis.
Biochimica et biophysica acta 2005;1725(3):283-9.
2005: Tse Siang Kang; Subramanian Vivekanandan; Seetharama D S Jois; R Manjunatha Kini
Effect of C-terminal amidation on folding and disulfide-pairing of alpha-conotoxin ImI.
Angewandte Chemie (International ed. in English) 2005;44(39):6333-7.
2005: Parayil Kumaran Ajikumar; Subramanian Vivekanandan; Rajamani Lakshminarayanan; Seetharama D S Jois; R Manjunatha Kini; Suresh Valiyaveettil
Mimicking the function of eggshell matrix proteins: the role of multiplets of charged amino acid residues and self-assembly of peptides in biomineralization.
Angewandte Chemie (International ed. in English) 2005;44(34):5476-9.
2005: Konerirajapuram N Sulochana; Huapeng Fan; Seetharama D S Jois; Vivekanandan Subramanian; Feng Sun; R Manjunatha Kini; Ruowen Ge
Peptides derived from human decorin leucine-rich repeat 5 inhibit angiogenesis.
The Journal of biological chemistry 2005;280(30):27935-48.
2005: R Manjunatha Kini
Structure-function relationships and mechanism of anticoagulant phospholipase A2 enzymes from snake venoms.
Toxicon : official journal of the International Society on Toxinology 2005;45(8):1147-61.
2005: R Manjunatha Kini
The intriguing world of prothrombin activators from snake venom.
Toxicon : official journal of the International Society on Toxinology 2005;45(8):1133-45.
2005: Rajamani Lakshminarayanan; Emma Ooi Chi-Jin; Xian Jun Loh; R Manjunatha Kini; Suresh Valiyaveettil
Purification and characterization of a vaterite-inducing peptide, pelovaterin, from the eggshells of Pelodiscus sinensis (Chinese soft-shelled turtle).
Biomacromolecules 2005;6(3):1429-37.
2005: Yuh Fen Pung; Peter T-H Wong; Prakash P Kumar; Wayne C Hodgson; R Manjunatha Kini
Ohanin, a novel protein from king cobra venom, induces hypolocomotion and hyperalgesia in mice.
The Journal of biological chemistry 2005;280(13):13137-47.
2005: Min Li; Bryan Fry; R Manjunatha Kini
Putting the brakes on snake venom evolution: the unique molecular evolutionary patterns of Aipysurus eydouxii (Marbled sea snake) phospholipase A2 toxins.
Molecular biology and evolution 2005;22(4):934-41.
2005: Rajamani Lakshminarayanan; Jeremiah S Joseph; R Manjunatha Kini; Suresh Valiyaveettil
Structure-function relationship of avian eggshell matrix proteins: a comparative study of two major eggshell matrix proteins, ansocalcin and OC-17.
Biomacromolecules 2005;6(2):741-51.
2005: Thi Nguyet Minh Le; Md Abu Reza; Sanjay Swarup; R Manjunatha Kini
Gene duplication of coagulation factor V and origin of venom prothrombin activator in Pseudonaja textilis snake.
Thrombosis and haemostasis 2005;93(3):420-9.
2005: Natalie G Lumsden; Bryan Fry; Sabatino Ventura; R Manjunatha Kini; Wayne C Hodgson
Pharmacological characterisation of a neurotoxin from the venom of Boiga dendrophila (mangrove catsnake).
Toxicon : official journal of the International Society on Toxinology 2005;45(3):329-34.
2005: Md Abu Reza; Sanjay Swarup; R Manjunatha Kini
Gene structures of trocarin D and coagulation factor X, two functionally diverse prothrombin activators from Australian rough scaled snake.
Pathophysiology of haemostasis and thrombosis 2005;34(4-5):205-8.
2005: R Manjunatha Kini
Serine proteases affecting blood coagulation and fibrinolysis from snake venoms.
Pathophysiology of haemostasis and thrombosis 2005;34(4-5):200-4.
2005: Yajnavalka Banerjee; Jun Mizuguchi; Sadaaki Iwanaga; R Manjunatha Kini
Hemextin AB complex--a snake venom anticoagulant protein complex that inhibits factor VIIa activity.
Pathophysiology of haemostasis and thrombosis 2005;34(4-5):184-7.
2005: Min Li; Bryan Fry; R Manjunatha Kini
Eggs-only diet: its implications for the toxin profile changes and ecology of the marbled sea snake (Aipysurus eydouxii).
Journal of molecular evolution 2005;60(1):81-9.
2005: R Manjunatha Kini; Yajnavalka Banerjee
Dissection approach: a simple strategy for the identification of the step of action of anticoagulant agents in the blood coagulation cascade.
Journal of thrombosis and haemostasis : JTH 2005;3(1):170-1.
2004: Roy Joseph; Susanta Pahari; Wayne C Hodgson; R Manjunatha Kini
Hypotensive agents from snake venoms.
Current drug targets. Cardiovascular & haematological disorders 2004;4(4):437-59.
2004: Jeremiah S Joseph; R Manjunatha Kini
Snake venom prothrombin activators similar to blood coagulation factor Xa.
Current drug targets. Cardiovascular & haematological disorders 2004;4(4):397-416.
2004: R Manjunatha Kini
Platelet aggregation and exogenous factors from animal sources.
Current drug targets. Cardiovascular & haematological disorders 2004;4(4):301-25.
2004: Natalie G Lumsden; Bryan Fry; Sabatino Ventura; R Manjunatha Kini; Wayne C Hodgson
The in vitro and in vivo pharmacological activity of Boiga dendrophila (mangrove catsnake) venom.
Autonomic & autacoid pharmacology 2004;24(4):107-13.
2003: R Manjunatha Kini
Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes.
Toxicon : official journal of the International Society on Toxinology 2003;42(8):827-40.
2003: Jeremiah S Joseph; Shoba Thirumangalathu; Fai Tsang; Fred W S Wong; R Manjunatha Kini
Trocarin, a blood coagulation factor Xa homologue from snake venom, causes inflammation and mitogenesis.
Toxicon : official journal of the International Society on Toxinology 2003;42(7):769-76.
2003: Allan M Torres; Hui Y Wong; Malan Desai; Shabbir M Moochhala; Philip W Kuchel; R Manjunatha Kini
Identification of a novel family of proteins in snake venoms. Purification and structural characterization of nawaprin from Naja nigricollis snake venom.
The Journal of biological chemistry 2003;278(41):40097-104.
2003: Bryan Fry; Natalie G Lumsden; Wolfgang Wüster; Janith C Wickramaratna; Wayne C Hodgson; R Manjunatha Kini
Isolation of a neurotoxin (alpha-colubritoxin) from a nonvenomous colubrid: evidence for early origin of venom in snakes.
Journal of molecular evolution 2003;57(4):446-52.
2003: Parayil Kumaran Ajikumar; Rajamani Lakshminarayanan; Boon Tee Ong; Suresh Valiyaveettil; R Manjunatha Kini
Eggshell matrix protein mimics: designer peptides to induce the nucleation of calcite crystal aggregates in solution.
Biomacromolecules 2003;4(5):1321-6.
2003: Veena Rao; Sanjay Swarup; R Manjunatha Kini
The nonenzymatic subunit of pseutarin C, a prothrombin activator from eastern brown snake (Pseudonaja textilis) venom, shows structural similarity to mammalian coagulation factor V.
Blood 2003;102(4):1347-54.
2003: Bryan Fry; Wolfgang Wüster; R Manjunatha Kini; Asif M Khan; A Khan; D Venkataraman; A P Rooney
Molecular evolution and phylogeny of elapid snake venom three-finger toxins.
Journal of molecular evolution 2003;57(1):110-29.
2003: Wensheng Zhang; Qiang Wu; Keng-Hock Pwee; Seetharama D S Jois; R Manjunatha Kini
Characterization of the interaction of wheat HMGa with linear and four-way junction DNAs.
Biochemistry 2003;42(21):6596-607.
2003: Selvanayagam Nirthanan; Eric Charpantier; Ponnampalam Gopalakrishnakone; Matthew C E Gwee; Hoon Eng Khoo; Li-Sam Cheah; R Manjunatha Kini; Daniel Bertrand
Neuromuscular effects of candoxin, a novel toxin from the venom of the Malayan krait (Bungarus candidus).
British journal of pharmacology 2003;139(4):832-44.
2003: Jeremiah S Joseph; Manojkumar Valiyaveettil; D C Gowda; R Manjunatha Kini
Occurrence of O-linked Xyl-GlcNAc and Xyl-Glc disaccharides in trocarin, a factor Xa homolog from snake venom.
Journal of thrombosis and haemostasis : JTH 2003;1(3):545-50.
2003: Selvanayagam Nirthanan; Ponnampalam Gopalakrishnakone; Matthew C E Gwee; Hoon Eng Khoo; R Manjunatha Kini
Non-conventional toxins from Elapid venoms.
Toxicon : official journal of the International Society on Toxinology 2003;41(4):397-407.
2003: Veena Rao; Jeremiah S Joseph; R Manjunatha Kini
Group D prothrombin activators from snake venom are structural homologues of mammalian blood coagulation factor Xa.
The Biochemical journal 2003;369(Pt 3):635-42.
2003: Rajamani Lakshminarayanan; Suresh Valiyaveettil; Veena Rao; R Manjunatha Kini
Purification, characterization, and in vitro mineralization studies of a novel goose eggshell matrix protein, ansocalcin.
The Journal of biological chemistry 2003;278(5):2928-36.
2003: Bryan Fry; Wolfgang Wüster; Sheik Fadil Ryan Ramjan; Timothy Jackson; Paolo Martelli; R Manjunatha Kini
Analysis of Colubroidea snake venoms by liquid chromatography with mass spectrometry: evolutionary and toxinological implications.
Rapid communications in mass spectrometry : RCM 2003;17(18):2047-62.
2003: Janith C Wickramaratna; Bryan Fry; Marie-Isabel Aguilar; R Manjunatha Kini; Wayne C Hodgson
Isolation and pharmacological characterization of a phospholipase A2 myotoxin from the venom of the Irian Jayan death adder (Acanthophis rugosus).
British journal of pharmacology 2003;138(2):333-42.
2002: Paola Pedarzani; Dieter D'hoedt; Kevina B Doorty; Jonathan D F Wadsworth; Jeremiah S Joseph; Kandiah Jeyaseelan; R Manjunatha Kini; S V Gadre; S M Sapatnekar; Martin Stocker; Peter N Strong
Tamapin, a venom peptide from the Indian red scorpion (Mesobuthus tamulus) that targets small conductance Ca2+-activated K+ channels and afterhyperpolarization currents in central neurons.
The Journal of biological chemistry 2002;277(48):46101-9.
2002: Veena Rao; R Manjunatha Kini
Pseutarin C, a prothrombin activator from Pseudonaja textilis venom: its structural and functional similarity to mammalian coagulation factor Xa-Va complex.
Thrombosis and haemostasis 2002;88(4):611-9.
2002: Leandra Watanabe; Selvanayagam Nirthanan; Ganapathy Rajaseger; Igor Polikarpov; R Manjunatha Kini; Raghuvir K Arni
Crystallization and preliminary X-ray analysis of bucain, a novel toxin from the Malayan krait Bungarus candidus.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 10 Pt 2):1879-81.
2002: R Manjunatha Kini
Molecular moulds with multiple missions: functional sites in three-finger toxins.
Clinical and experimental pharmacology & physiology 2002;29(9):815-22.
2002: Matthew C E Gwee; Selvanayagam Nirthanan; Hoon Eng Khoo; Ponnampalam Gopalakrishnakone; R Manjunatha Kini; Li-Sam Cheah
Autonomic effects of some scorpion venoms and toxins.
Clinical and experimental pharmacology & physiology 2002;29(9):795-801.
2002: Kellathur N Srinivasan; Vaithiyalingam Sivaraja; Isabelle Huys; Toru Sasaki; Betty Cheng; Thallampuranam Krishnaswamy S Kumar; Kazuki Sato; Jan Tytgat; Chin Yu; B Chia Cheng San; Shoba Ranganathan; H John Bowie; R Manjunatha Kini; Ponnampalam Gopalakrishnakone
kappa-Hefutoxin1, a novel toxin from the scorpion Heterometrus fulvipes with unique structure and function. Importance of the functional diad in potassium channel selectivity.
The Journal of biological chemistry 2002;277(33):30040-7.
2002: Selvanayagam Nirthanan; Eric Charpantier; Ponnampalam Gopalakrishnakone; Matthew C E Gwee; Hoon Eng Khoo; Li-Sam Cheah; Daniel Bertrand; R Manjunatha Kini
Candoxin, a novel toxin from Bungarus candidus, is a reversible antagonist of muscle (alphabetagammadelta ) but a poorly reversible antagonist of neuronal alpha 7 nicotinic acetylcholine receptors.
The Journal of biological chemistry 2002;277(20):17811-20.
2002: Rajamani Lakshminarayanan; R Manjunatha Kini; Suresh Valiyaveettil
Investigation of the role of ansocalcin in the biomineralization in goose eggshell matrix.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(8):5155-9.
2002: Jeremiah S Joseph; Maxey C M Chung; Peter Mirtschin; R Manjunatha Kini
Effect of snake venom procoagulants on snake plasma: implications for the coagulation cascade of snakes.
Toxicon : official journal of the International Society on Toxinology 2002;40(2):175-83.
2002: Bryan Fry; Janith C Wickramaratna; Wayne C Hodgson; Paul F Alewood; R Manjunatha Kini; Hao Ho; Wolfgang Wüster
Electrospray liquid chromatography/mass spectrometry fingerprinting of Acanthophis (death adder) venoms: taxonomic and toxinological implications.
Rapid communications in mass spectrometry : RCM 2002;16(6):600-8.
2002: Kellathur N Srinivasan; Ponnampalam Gopalakrishnakone; Paul Thiam Joo Tan; K C Chew; Betty Cheng; R Manjunatha Kini; Judice L Y Koh; Seng Hong Seah; Vladimir Brusic
SCORPION, a molecular database of scorpion toxins.
Toxicon : official journal of the International Society on Toxinology 2002;40(1):23-31.
2001: Allan M Torres; R Manjunatha Kini; N Selvanayagam; Philip W Kuchel
NMR structure of bucandin, a neurotoxin from the venom of the Malayan krait (Bungarus candidus).
The Biochemical journal 2001;360(Pt 3):539-48.
2001: Jeremiah S Joseph; R Manjunatha Kini
Snake venom prothrombin activators homologous to blood coagulation factor Xa.
Haemostasis 2001;31(3-6):234-40.
2001: R Manjunatha Kini; Veena Rao; Jeremiah S Joseph
Procoagulant proteins from snake venoms.
Haemostasis 2001;31(3-6):218-24.
2001: Yeow Leng Chua; Keng-Hock Pwee; R Manjunatha Kini; C Y Leng; P K Hock
DNA binding mediated by the wheat HMGa protein: a novel instance of selectivity against alternating GC sequence.
Plant molecular biology 2001;46(2):193-204.
2001: D C Tan; R Manjunatha Kini; Seetharama D S Jois; D K Lim; L Xin; R Ge
A small peptide derived from Flt-1 (VEGFR-1) functions as an angiogenic inhibitor.
FEBS letters 2001;494(3):150-6.
2001: Kellathur N Srinivasan; Selvanayagam Nirthanan; T Sasaki; K Sato; Betty Cheng; Matthew C E Gwee; R Manjunatha Kini; Ponnampalam Gopalakrishnakone
Functional site of bukatoxin, an alpha-type sodium channel neurotoxin from the Chinese scorpion (Buthus martensi Karsch) venom: probable role of the (52)PDKVP(56) loop.
FEBS letters 2001;494(3):145-9.
2001: Rong Gao; R Manjunatha Kini; G Li; R Luo; Zachariah E Selvanayagam; Ponnampalam Gopalakrishnakone
Purification and properties of three new phospholipase A2 isoenzymes from Micropechis ikaheka venom.
Biochimica et biophysica acta 2001;1545(1-2):30-40.
2001: Peter N Strong; G S Clark; Arunmozhiarasi Armugam; F A De-Allie; Jeremiah S Joseph; V Yemul; J M Deshpande; R Kamat; S V Gadre; Ponnampalam Gopalakrishnakone; R Manjunatha Kini; D G Owen; Kandiah Jeyaseelan
Tamulustoxin: a novel potassium channel blocker from the venom of the Indian red scorpion Mesobuthus tamulus.
Archives of biochemistry and biophysics 2001;385(1):138-44.
2001: R Manjunatha Kini; G Chow
Exogenous inhibitors of platelet aggregation from animal sources.
Thrombosis and haemostasis 2001;85(1):179-81.
2001: G Chow; R Manjunatha Kini
Exogenous factors from animal sources that induce platelet aggregation.
Thrombosis and haemostasis 2001;85(1):177-8.
2000: R A Balaji; A Ohtake; Kazuki Sato; Ponnampalam Gopalakrishnakone; R Manjunatha Kini; K T Seow; Boon-Huat Bay
lambda-conotoxins, a new family of conotoxins with unique disulfide pattern and protein folding. Isolation and characterization from the venom of Conus marmoreus.
The Journal of biological chemistry 2000;275(50):39516-22.
2000: Peter Kuhn; A M Deacon; S Comoso; Ganapathy Rajaseger; R Manjunatha Kini; I Usón; Prasanna R Kolatkar
The atomic resolution structure of bucandin, a novel toxin isolated from the Malayan krait, determined by direct methods.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 11):1401-7.
2000: Maung-Maung Thwin; Ponnampalam Gopalakrishnakone; R Manjunatha Kini; Arunmozhiarasi Armugam; Kandiah Jeyaseelan
Recombinant antitoxic and antiinflammatory factor from the nonvenomous snake Python reticulatus: phospholipase A2 inhibition and venom neutralizing potential.
Biochemistry 2000;39(31):9604-11.
2000: R A Balaji; T Sasaki; Ponnampalam Gopalakrishnakone; K Sato; R Manjunatha Kini; B H Bay
Purification, structure determination and synthesis of covalitoxin-II, a short insect-specific neurotoxic peptide from the venom of the Coremiocnemis validus (Singapore tarantula).
FEBS letters 2000;474(2-3):208-12.
2000: S B Singh; Arunmozhiarasi Armugam; R Manjunatha Kini; Kandiah Jeyaseelan
Phospholipase A(2) with platelet aggregation inhibitor activity from Austrelaps superbus venom: protein purification and cDNA cloning.
Archives of biochemistry and biophysics 2000;375(2):289-303.
2000: Jayshree L Hirpara; M A Seyed; KW Loh; H Dong; R Manjunatha Kini; Jason Yongsheng Chan
Induction of mitochondrial permeability transition and cytochrome C release in the absence of caspase activation is insufficient for effective apoptosis in human leukemia cells.
Blood 2000;95(5):1773-80.
1999: Rong Gao; R Manjunatha Kini; Ponnampalam Gopalakrishnakone
Purification, properties, and amino acid sequence of a hemoglobinuria-inducing phospholipase A(2), MiPLA-1, from Micropechis ikaheka venom.
Archives of biochemistry and biophysics 1999;369(1):181-92.
1999: Jeremiah S Joseph; Maxey C M Chung; Kandiah Jeyaseelan; R Manjunatha Kini
Amino acid sequence of trocarin, a prothrombin activator from Tropidechis carinatus venom: its structural similarity to coagulation factor Xa.
Blood 1999;94(2):621-31.
1999: R Wang; R Manjunatha Kini; Maxey C M Chung
Rhodocetin, a novel platelet aggregation inhibitor from the venom of Calloselasma rhodostoma (Malayan pit viper): synergistic and noncovalent interaction between its subunits.
Biochemistry 1999;38(23):7584-93.
1999: R Manjunatha Kini; Y M Chan
Accelerated evolution and molecular surface of venom phospholipase A2 enzymes.
Journal of molecular evolution 1999;48(2):125-32.
1998: H Dong; S X Chen; R Manjunatha Kini; Hong Xi XU
Effects of tannins from Geum japonicum on the catalytic activity of thrombin and factor Xa of blood coagulation cascade.
Journal of natural products 1998;61(11):1356-60.
1998: R Manjunatha Kini
Proline brackets and identification of potential functional sites in proteins: toxins to therapeutics.
Toxicon : official journal of the International Society on Toxinology 1998;36(11):1659-70.
1998: G Chow; S Subburaju; R Manjunatha Kini
Purification, characterization, and amino acid sequence determination of acanthins, potent inhibitors of platelet aggregation from Acanthophis antarcticus (common death adder) venom.
Archives of biochemistry and biophysics 1998;354(2):232-8.
1997: S Subburaju; R Manjunatha Kini
Isolation and purification of superbins I and II from Austrelaps superbus (copperhead) snake venom and their anticoagulant and antiplatelet effects.
Toxicon : official journal of the International Society on Toxinology 1997;35(8):1239-50.
1997: D Chen; R Manjunatha Kini; R Yuen; Hoon Eng Khoo
Haemolytic activity of stonustoxin from stonefish (Synanceja horrida) venom: pore formation and the role of cationic amino acid residues.
The Biochemical journal 1997;325 ( Pt 3)():685-91.
1997: J P Gong; Matthew C E Gwee; Ponnampalam Gopalakrishnakone; R Manjunatha Kini; M C Chung
Adrenergic and nitrergic responses of the rat isolated anococcygeus muscle to a new toxin (makatoxin I) from the venom of the scorpion Buthus martensi Karsch.
Journal of autonomic pharmacology 1997;17(2):129-35.
1997: R Manjunatha Kini; C Y Zhang; B K Tan
Pharmacological activity of the interdomain segment between metalloproteinase and disintegrin domains.
Toxicon : official journal of the International Society on Toxinology 1997;35(4):529-35.
1997: J Gong; R Manjunatha Kini; Matthew C E Gwee; Ponnampalam Gopalakrishnakone; M C Chung
Makatoxin I, a novel toxin isolated from the venom of the scorpion Buthus martensi Karsch, exhibits nitrergic actions.
The Journal of biological chemistry 1997;272(13):8320-4.
1997: M Z Huang; Ponnampalam Gopalakrishnakone; Maxey C M Chung; R Manjunatha Kini
Complete amino acid sequence of an acidic, cardiotoxic phospholipase A2 from the venom of Ophiophagus hannah (King Cobra): a novel cobra venom enzyme with "pancreatic loop".
Archives of biochemistry and biophysics 1997;338(2):150-6.
1997: M Z Huang; Ponnampalam Gopalakrishnakone; R Manjunatha Kini
Role of enzymatic activity in the antiplatelet effects of a phospholipase A2 from Ophiophagus hannah snake venom.
Life sciences 1997;61(22):2211-7.
1996: R Manjunatha Kini
Are C-type lectin-related proteins derived by proteolysis of metalloproteinase/disintegrin precursor proteins?
Toxicon : official journal of the International Society on Toxinology 1996;34(11-12):1287-94.
1996: FJ Ghadessy; D Chen; R Manjunatha Kini; Maxey C M Chung; Kandiah Jeyaseelan; Hoon Eng Khoo; R Yuen
Stonustoxin is a novel lethal factor from stonefish (Synanceja horrida) venom. cDNA cloning and characterization.
The Journal of biological chemistry 1996;271(41):25575-81.
1995: R Manjunatha Kini
Do we know the complete sequence of metalloproteinase and nonenzymatic platelet aggregation inhibitor (disintegrin) precursor proteins?
Toxicon : official journal of the International Society on Toxinology 1995;33(9):1151-60.