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Stefan Kins

Research Profile

Chemicals & Drugs

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Alzheimer's Disease

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Publications

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Marcus Otto Walter Grimm; Sven Grösgen; Verena K Burg; Petra Friess; Heike S Grimm; Viola J Haupenthal; Benjamin Hundsdörfer; Stefan Kins; Tatjana L Rothhaar; Tobias Hartmann
Trans fatty acids enhance amyloidogenic processing of the Alzheimer amyloid precursor protein (APP).
Simone Isbert; Stefan Kins; Gerd Multhaup; Andrea Schweitzer; Katja Wagner; Sascha Weggen; Simone Eggert; Claus U Pietrzik
APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms.
Silke Brunholz; Carole Deyts; Stefan Kins; Alfredo Lorenzo; Sangram Sisodia; Gerardo Morfini
Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells.

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All Publications

2012: Marcus Otto Walter Grimm; Sven Grösgen; Verena K Burg; Petra Friess; Heike S Grimm; Viola J Haupenthal; Benjamin Hundsdörfer; Stefan Kins; Tatjana L Rothhaar; Tobias Hartmann
Trans fatty acids enhance amyloidogenic processing of the Alzheimer amyloid precursor protein (APP).
The Journal of nutritional biochemistry 2012;23(10):1214-23.
2012: Simone Isbert; Stefan Kins; Gerd Multhaup; Andrea Schweitzer; Katja Wagner; Sascha Weggen; Simone Eggert; Claus U Pietrzik
APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms.
Cellular and molecular life sciences : CMLS 2012;69(8):1353-75.
2012: Silke Brunholz; Carole Deyts; Stefan Kins; Alfredo Lorenzo; Sangram Sisodia; Gerardo Morfini
Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 2012;217(3-4):353-64.
2012: Frederik Baumkötter; Simone Eggert; Katja Wagner; Klemens Wild; Stefan Kins
Structural aspects and physiological consequences of APP/APLP trans-dimerization.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 2012;217(3-4):389-95.
2009: Anita Szodorai; Yung-Hui Kuan; Silke Hunzelmann; Ulrike Engel; Ayuko Sakane; Takuya Sasaki; Yoshimi Takai; Joachim Kirsch; Ulrike Müller; Konrad Beyreuther; Scott T Brady; Gerardo Morfini; Stefan Kins
APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(46):14534-44.
2008: Scott R DeBoer; YiMei You; Anita Szodorai; Agnieszka Kaminska; Gustavo Pigino; Evelyn Nwabuisi; Bin Wang; Tatiana Estrada-Hernandez; Stefan Kins; Scott T Brady; Gerardo Morfini
Conventional kinesin holoenzymes are composed of heavy and light chain homodimers.
Biochemistry 2008;47(15):4535-43.
2007: Simone Back; Petra Haas; Jakob Tschaepe; Tomas Gruebl; Joachim Kirsch; Ulrike Müller; Konrad Beyreuther; Stefan Kins
beta-amyloid precursor protein can be transported independent of any sorting signal to the axonal and dendritic compartment.
Journal of neuroscience research 2007;85(12):2580-90.
2007: Patricia Rusu; Anna Jansen; Peter Soba; Joachim Kirsch; Alexander Löwer; Gunter Merdes; Yung-Hui Kuan; Anita Jung; Konrad Beyreuther; Ole Kjaerulff; Stefan Kins
Axonal accumulation of synaptic markers in APP transgenic Drosophila depends on the NPTY motif and is paralleled by defects in synaptic plasticity.
The European journal of neuroscience 2007;25(4):1079-86.
2006: Yung-Hui Kuan; Tomas Gruebl; Peter Soba; Simone Eggert; Iva Nesic; Simone Back; Joachim Kirsch; Konrad Beyreuther; Stefan Kins
PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2.
The Journal of biological chemistry 2006;281(52):40114-23.
2006: Jürgen Götz; Lars M Ittner; Stefan Kins
Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease?
Journal of neurochemistry 2006;98(4):993-1006.
2006: Stefan Kins; Konrad Beyreuther
Teasing out the tangles.
Nature medicine 2006;12(7):764-5; discussion 765.
2006: Friederike Hörster; Marina A Schwab; Sven W Sauer; Joachim Pietz; Georg F Hoffmann; Jürgen G Okun; Stefan Kölker; Stefan Kins
Phenylalanine reduces synaptic density in mixed cortical cultures from mice.
Pediatric research 2006;59(4 Pt 1):544-8.
2006: Stefan Kins; Nadine Lauther; Anita Szodorai; Konrad Beyreuther
Subcellular trafficking of the amyloid precursor protein gene family and its pathogenic role in Alzheimer's disease.
Neuro-degenerative diseases 2006;3(4-5):218-26.
2005: Peter Soba; Simone Eggert; Katja Wagner; Hanswalter Zentgraf; Katjuscha Siehl; Sylvia Kreger; Alexander Löwer; Andreas Langer; Gunter Merdes; Renato Paro; Colin L Masters; Ulrike Müller; Stefan Kins; Konrad Beyreuther
Homo- and heterodimerization of APP family members promotes intercellular adhesion.
The EMBO journal 2005;24(20):3624-34.
2005: Orly Lazarov; Gerardo Morfini; Edward B Lee; Mohamed H Farah; Anita Szodorai; Scott R DeBoer; Vassilis E Koliatsos; Stefan Kins; Virginia M-Y Lee; Philip C Wong; Donald L Price; Scott T Brady; Sangram S Sisodia
Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(9):2386-95.
2005: Ruth C von Rotz; Stefan Kins; Rainer Hipfel; Heinz von der Kammer; Roger M Nitsch
The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease.
The European journal of neuroscience 2005;21(5):1289-98.
2003: Stefan Kins; Pascal Kurosinski; Roger M Nitsch; Jürgen Götz
Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice.
The American journal of pathology 2003;163(3):833-43.
2002: Karsten Schmidt; Stefan Kins; Andreas Schild; Roger M Nitsch; Brian A Hemmings; Jürgen Götz
Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A.
The European journal of neuroscience 2002;16(11):2039-48.
2002: Jens C Fuhrmann; Stefan Kins; Philippe Rostaing; Oussama El Far; Joachim Kirsch; Morgan Sheng; Antoine Triller; Heinrich Betz; Matthias Kneussel
Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(13):5393-402.
2002: Ulrike Müller; Stefan Kins
APP on the move.
Trends in molecular medicine 2002;8(4):152-5.
2001: Stefan Kins; Arames Crameri; D R Evans; Brian A Hemmings; Roger M Nitsch; J Gotz
Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice.
The Journal of biological chemistry 2001;276(41):38193-200.
2001: Y Grosskreutz; A Hermann; Stefan Kins; Jens C Fuhrmann; Heinrich Betz; Matthias Kneussel
Identification of a gephyrin-binding motif in the GDP/GTP exchange factor collybistin.
Biological chemistry 2001;382(10):1455-62.
2001: T Steinhoff; Eva Moritz; M Axel Wollmer; M Hasan Mohajeri; Stefan Kins; Roger M Nitsch
Increased cystatin C in astrocytes of transgenic mice expressing the K670N-M671L mutation of the amyloid precursor protein and deposition in brain amyloid plaques.
Neurobiology of disease 2001;8(4):647-54.
2000: M Ramming; Stefan Kins; N Werner; A Hermann; Heinrich Betz; Joachim Kirsch
Diversity and phylogeny of gephyrin: tissue-specific splice variants, gene structure, and sequence similarities to molybdenum cofactor-synthesizing and cytoskeleton-associated proteins.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(18):10266-71.
2000: Stefan Kins; Heinrich Betz; Joachim Kirsch
Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin.
Nature neuroscience 2000;3(1):22-9.
1999: Stefan Kins; Jochen Kuhse; Bodo Laube; Heinrich Betz; Joachim Kirsch
Incorporation of a gephyrin-binding motif targets NMDA receptors to gephyrin-rich domains in HEK 293 cells.
The European journal of neuroscience 1999;11(2):740-4.