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Therese Kinsella

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Gabriel Birrane; B Therese Kinsella; Eamon P Mulvaney; Rinku Pal; Olivier Kocher
Molecular analysis of the prostacyclin receptor's interaction with the PDZ1 domain of its adaptor protein PDZK1.
Elizebeth C Turner; B Therese Kinsella
Regulation of the human prostacyclin receptor gene by the cholesterol-responsive SREBP1.
Helen M Reid; Elizebeth C Turner; Paula B Hyland; Caitriona McLean; Eamon P Mulvaney; B Therese Kinsella
Interaction of the human prostacyclin receptor and the NHERF4 family member intestinal and kidney enriched PDZ protein (IKEPP).

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All Publications

2013: Gabriel Birrane; B Therese Kinsella; Eamon P Mulvaney; Rinku Pal; Olivier Kocher
Molecular analysis of the prostacyclin receptor's interaction with the PDZ1 domain of its adaptor protein PDZK1.
PloS one 2013;8(2):e53819.
2012: Elizebeth C Turner; B Therese Kinsella
Regulation of the human prostacyclin receptor gene by the cholesterol-responsive SREBP1.
Journal of lipid research 2012;53(11):2390-404.
2012: Helen M Reid; Elizebeth C Turner; Paula B Hyland; Caitriona McLean; Eamon P Mulvaney; B Therese Kinsella
Interaction of the human prostacyclin receptor and the NHERF4 family member intestinal and kidney enriched PDZ protein (IKEPP).
Biochimica et biophysica acta 2012;1823(10):1998-2012.
2012: Garret L Keating; Elizebeth C Turner; B Therese Kinsella
Regulation of the human prostacyclin receptor gene in megakaryocytes: major roles for C/EBPδ and PU.1.
Biochimica et biophysica acta 2012;1819(5):428-45.
2011: Elizebeth C Turner; Eamon P Mulvaney; Helen M Reid; B Therese Kinsella
Interaction of the human prostacyclin receptor with the PDZ adapter protein PDZK1: role in endothelial cell migration and angiogenesis.
Molecular biology of the cell 2011;22(15):2664-79.
2011: Elizebeth C Turner; David J Kavanagh; Eamon P Mulvaney; Caitriona McLean; Katarina Wikström; Helen M Reid; B Therese Kinsella
Identification of an interaction between the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor with protein kinase C-related kinase (PRK) 1: implications for prostate cancer.
The Journal of biological chemistry 2011;286(17):15440-57.
2011: Peter D Donnellan; Cisca C Kimbembe; Helen M Reid; B Therese Kinsella
Identification of a novel endoplasmic reticulum export motif within the eighth α-helical domain (α-H8) of the human prostacyclin receptor.
Biochimica et biophysica acta 2011;1808(4):1202-18.
2011: Helen M Reid; Katarina Wikström; David J Kavanagh; Eamon P Mulvaney; B Therese Kinsella
Interaction of angio-associated migratory cell protein with the TPα and TPβ isoforms of the human thromboxane A₂ receptor.
Cellular signalling 2011;23(4):700-17.
2010: Helen M Reid; Eamon P Mulvaney; Elizebeth C Turner; B Therese Kinsella
Interaction of the human prostacyclin receptor with Rab11: characterization of a novel Rab11 binding domain within alpha-helix 8 that is regulated by palmitoylation.
The Journal of biological chemistry 2010;285(24):18709-26.
2010: Elizebeth C Turner; B Therese Kinsella
Estrogen increases expression of the human prostacyclin receptor within the vasculature through an ERalpha-dependent mechanism.
Journal of molecular biology 2010;396(3):473-86.
2009: AnneMarie M Gannon; Elizebeth C Turner; Helen M Reid; B Therese Kinsella
Regulated expression of the alpha isoform of the human thromboxane A2 receptor during megakaryocyte differentiation: a coordinated role for WT1, Egr1, and Sp1.
Journal of molecular biology 2009;394(1):29-45.
2009: Helen M Reid; B Therese Kinsella
Intermolecular cross-talk between the prostaglandin E2 receptor (EP)3 of subtype and thromboxane A(2) receptor signalling in human erythroleukaemic cells.
British journal of pharmacology 2009;158(3):830-47.
2009: Elizebeth C Turner; B Therese Kinsella
Transcriptional regulation of the human prostacyclin receptor gene is dependent on Sp1, PU.1 and Oct-1 in megakaryocytes and endothelial cells.
Journal of molecular biology 2009;386(3):579-97.
2009: Peter D Donnellan; B Therese Kinsella
Immature and mature species of the human Prostacyclin Receptor are ubiquitinated and targeted to the 26S proteasomal or lysosomal degradation pathways, respectively.
Journal of molecular signaling 2009;4():7.
2008: Katarina Wikström; Helen M Reid; Maria Hill; Karol A English; Martina B O'Keeffe; Cisca C Kimbembe; B Therese Kinsella
Recycling of the human prostacyclin receptor is regulated through a direct interaction with Rab11a GTPase.
Cellular signalling 2008;20(12):2332-46.
2008: AnneMarie M Gannon; B Therese Kinsella
Regulation of the human thromboxane A2 receptor gene by Sp1, Egr1, NF-E2, GATA-1, and Ets-1 in megakaryocytes.
Journal of lipid research 2008;49(12):2590-604.
2008: Martina B O'Keeffe; Helen M Reid; B Therese Kinsella
Agonist-dependent internalization and trafficking of the human prostacyclin receptor: a direct role for Rab5a GTPase.
Biochimica et biophysica acta 2008;1783(10):1914-28.
2008: Katarina Wikström; David J Kavanagh; Helen M Reid; B Therese Kinsella
Differential regulation of RhoA-mediated signaling by the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor: independent modulation of TPalpha signaling by prostacyclin and nitric oxide.
Cellular signalling 2008;20(8):1497-512.
2007: Julien Hanson; Jean-Michel Dogné; Jérémie Ghiotto; Anne-Lise Moray; B Therese Kinsella; Bernard Pirotte
Design, synthesis, and SAR study of a series of N-alkyl-N'-[2-(aryloxy)-5-nitrobenzenesulfonyl]ureas and -cyanoguanidine as selective antagonists of the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor.
Journal of medicinal chemistry 2007;50(16):3928-36.
2007: Leanne P Kelley-Hickie; Martina B O'Keeffe; Helen M Reid; B Therese Kinsella
Homologous desensitization of signalling by the alpha (alpha) isoform of the human thromboxane A2 receptor: a specific role for nitric oxide signalling.
Biochimica et biophysica acta 2007;1773(6):970-89.
2007: Derick Mitchell; Sarah J O'Meara; Andrew Gaffney; John K G Crean; B Therese Kinsella; Catherine Godson
The Lipoxin A4 receptor is coupled to SHP-2 activation: implications for regulation of receptor tyrosine kinases.
The Journal of biological chemistry 2007;282(21):15606-18.
2007: Helen M Reid; B Therese Kinsella
Palmitoylation of the TPbeta isoform of the human thromboxane A2 receptor. Modulation of G protein: effector coupling and modes of receptor internalization.
Cellular signalling 2007;19(5):1056-70.
2006: Leanne P Kelley-Hickie; B Therese Kinsella
Homologous desensitization of signalling by the beta (beta) isoform of the human thromboxane A2 receptor.
Biochimica et biophysica acta 2006;1761(9):1114-31.
2006: Julien Hanson; Denis Reynaud; Na Qiao; Philippe Devel; Anne-Lise Moray; Jean-François Renard; Leanne P Kelley; Jean-Yves Winum; Jean-Louis Montero; B Therese Kinsella; Bernard Pirotte; Cecil R Pace-Asciak; Jean-Michel Dogné
Synthesis and pharmacological evaluation of novel nitrobenzenic thromboxane modulators as antiplatelet agents acting on both the alpha and beta isoforms of the human thromboxane receptor.
Journal of medicinal chemistry 2006;49(12):3701-9.
2006: Adrian T Coyle; B Therese Kinsella
Synthetic peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone suppress transcription by promoter 3 of the human thromboxane A2 receptor gene in human erythroleukemia cells.
Biochemical pharmacology 2006;71(9):1308-23.
2005: Adrian T Coyle; Martina B O'Keeffe; B Therese Kinsella
15-deoxy Delta12,14-prostaglandin J2 suppresses transcription by promoter 3 of the human thromboxane A2 receptor gene through peroxisome proliferator-activated receptor gamma in human erythroleukemia cells.
The FEBS journal 2005;272(18):4754-73.
2005: Julien Hanson; Stéphanie Rolin; Denis Reynaud; Na Qiao; Leanne P Kelley; Helen M Reid; François Valentin; John R Tippins; B Therese Kinsella; Bernard Masereel; Cecil R Pace-Asciak; Bernard Pirotte; Jean-Michel Dogné
In vitro and in vivo pharmacological characterization of BM-613 [N-n-pentyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea], a novel dual thromboxane synthase inhibitor and thromboxane receptor antagonist.
The Journal of pharmacology and experimental therapeutics 2005;313(1):293-301.
2005: Sarah J O'Meara; B Therese Kinsella
The effect of the farnesyl protein transferase inhibitor SCH66336 on isoprenylation and signalling by the prostacyclin receptor.
The Biochemical journal 2005;386(Pt 1):177-89.
2005: Adrian T Coyle; B Therese Kinsella
Characterization of promoter 3 of the human thromboxane A receptor gene. A functional AP-1 and octamer motif are required for basal promoter activity.
The FEBS journal 2005;272(4):1036-53.
2004: Sarah J O'Meara; B Therese Kinsella
Investigation of the effect of the farnesyl protein transferase inhibitor R115777 on isoprenylation and intracellular signalling by the prostacyclin receptor.
British journal of pharmacology 2004;143(2):318-30.
2004: Sarah J O'Meara; B Therese Kinsella
Effect of the statin atorvastatin on intracellular signalling by the prostacyclin receptor in vitro and in vivo.
British journal of pharmacology 2004;143(2):292-302.
2004: Leanne P Kelley-Hickie; B Therese Kinsella
EP1- and FP-mediated cross-desensitization of the alpha (alpha) and beta (beta) isoforms of the human thromboxane A2 receptor.
British journal of pharmacology 2004;142(1):203-21.
2003: Helen M Reid; B Therese Kinsella
The alpha, but not the beta, isoform of the human thromboxane A2 receptor is a target for nitric oxide-mediated desensitization. Independent modulation of Tp alpha signaling by nitric oxide and prostacyclin.
The Journal of biological chemistry 2003;278(51):51190-202.
2003: Leanne P Kelley; B Therese Kinsella
The role of N-linked glycosylation in determining the surface expression, G protein interaction and effector coupling of the alpha (alpha) isoform of the human thromboxane A(2) receptor.
Biochimica et biophysica acta 2003;1621(2):192-203.
2003: Sinead M Miggin; Orlaith A Lawler; B Therese Kinsella
Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation.
The Journal of biological chemistry 2003;278(9):6947-58.
2002: Adrian T Coyle; Sinead M Miggin; B Therese Kinsella
Characterization of the 5' untranslated region of alpha and beta isoforms of the human thromboxane A2 receptor (TP). Differential promoter utilization by the TP isoforms.
European journal of biochemistry / FEBS 2002;269(16):4058-73.
2002: Sinead M Miggin; B Therese Kinsella
Investigation of the mechanisms of G protein: effector coupling by the human and mouse prostacyclin receptors. Identification of critical species-dependent differences.
The Journal of biological chemistry 2002;277(30):27053-64.
2002: Sinead M Miggin; B Therese Kinsella
Regulation of extracellular signal-regulated kinase cascades by alpha- and beta-isoforms of the human thromboxane A(2) receptor.
Molecular pharmacology 2002;61(4):817-31.
2002: Sinead M Miggin; Orlaith A Lawler; B Therese Kinsella
Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor.
European journal of biochemistry / FEBS 2002;269(6):1714-25.
2001: B Therese Kinsella
Thromboxane A2 signalling in humans: a 'Tail' of two receptors.
Biochemical Society transactions 2001;29(Pt 6):641-54.
2001: Orlaith A Lawler; Sinead M Miggin; B Therese Kinsella
Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling.
The Journal of biological chemistry 2001;276(36):33596-607.
2001: JF Foley; L P Kelley; B Therese Kinsella
Prostaglandin D(2) receptor-mediated desensitization of the alpha isoform of the human thromboxane A(2) receptor.
Biochemical pharmacology 2001;62(2):229-39.
2001: Sinead M Miggin; B Therese Kinsella
Thromboxane A(2) receptor mediated activation of the mitogen activated protein kinase cascades in human uterine smooth muscle cells.
Biochimica et biophysica acta 2001;1539(1-2):147-62.
2001: Orlaith A Lawler; Sinead M Miggin; B Therese Kinsella
The effects of the statins lovastatin and cerivastatin on signalling by the prostanoid IP-receptor.
British journal of pharmacology 2001;132(8):1639-49.
2000: MT Walsh; B Therese Kinsella
Regulation of the human prostanoid TPalpha and TPbeta receptor isoforms mediated through activation of the EP(1) and IP receptors.
British journal of pharmacology 2000;131(3):601-9.
2000: MT Walsh; JF Foley; B Therese Kinsella
The alpha, but not the beta, isoform of the human thromboxane A2 receptor is a target for prostacyclin-mediated desensitization.
The Journal of biological chemistry 2000;275(27):20412-23.
2000: M Walsh; JF Foley; B Therese Kinsella
Investigation of the role of the carboxyl-terminal tails of the alpha and beta isoforms of the human thromboxane A(2) receptor (TP) in mediating receptor:effector coupling.
Biochimica et biophysica acta 2000;1496(2-3):164-82.
1999: J S Hayes; Orlaith A Lawler; MT Walsh; B Therese Kinsella
The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling.
The Journal of biological chemistry 1999;274(34):23707-18.
1998: Sinead M Miggin; B Therese Kinsella
Expression and tissue distribution of the mRNAs encoding the human thromboxane A2 receptor (TP) alpha and beta isoforms.
Biochimica et biophysica acta 1998;1425(3):543-59.
1998: MT Walsh; JF Foley; B Therese Kinsella
Characterization of the role of N-linked glycosylation on the cell signaling and expression of the human thromboxane A2 receptor alpha and beta isoforms.
The Journal of pharmacology and experimental therapeutics 1998;286(2):1026-36.
1997: B Therese Kinsella; D J O'Mahony; garret fitzgerald
The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha.
The Journal of pharmacology and experimental therapeutics 1997;281(2):957-64.
1995: B Therese Kinsella; D J O'Mahony; F Griffin; garret fitzgerald
Regulated expression of the gene coding for the human thromboxane A2 receptor.
Advances in prostaglandin, thromboxane, and leukotriene research 1995;23():247-9.
1994: B Therese Kinsella; D J O'Mahony; garret fitzgerald
Phosphorylation and regulated expression of the human thromboxane A2 receptor.
The Journal of biological chemistry 1994;269(47):29914-9.
1994: B Therese Kinsella; D O'Mahony; John A Lawson; Domenico Pratico'; garret fitzgerald
Cellular activation of thromboxane receptors.
Annals of the New York Academy of Sciences 1994;714():270-8.
1993: S D Smith; D J O'Mahony; B Therese Kinsella; Lawrence Rothblum
Transcription from the rat 45S ribosomal DNA promoter does not require the factor UBF.
Gene expression 1993;3(3):229-36.