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Volker Kinzel

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TOP 3
Manuela Klingler-Hoffmann; Holger Barth; James Richards; Norbert König; Volker Kinzel
Downregulation of protein phosphatase 2A activity in HeLa cells at the G2-mitosis transition and unscheduled reactivation induced by 12-O-tetradecanoyl phorbol-13-acetate (TPA).
Christine B Breitenlechner; Richard A Engh; Robert Huber; Volker Kinzel; Dirk Bossemeyer; Michael Gassel
The typically disordered N-terminus of PKA can fold as a helix and project the myristoylation site into solution.
Christine B Breitenlechner; Michael Gassel; Hiroyoshi Hidaka; Volker Kinzel; Robert Huber; Richard A Engh; Dirk Bossemeyer
Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity.

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2005: Manuela Klingler-Hoffmann; Holger Barth; James Richards; Norbert König; Volker Kinzel
Downregulation of protein phosphatase 2A activity in HeLa cells at the G2-mitosis transition and unscheduled reactivation induced by 12-O-tetradecanoyl phorbol-13-acetate (TPA).
European journal of cell biology 2005;84(8):719-32.
2004: Christine B Breitenlechner; Richard A Engh; Robert Huber; Volker Kinzel; Dirk Bossemeyer; Michael Gassel
The typically disordered N-terminus of PKA can fold as a helix and project the myristoylation site into solution.
Biochemistry 2004;43(24):7743-9.
2003: Christine B Breitenlechner; Michael Gassel; Hiroyoshi Hidaka; Volker Kinzel; Robert Huber; Richard A Engh; Dirk Bossemeyer
Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity.
Structure (London, England : 1993) 2003;11(12):1595-607.
2001: A Tholey; Rüdiger Pipkorn; Dirk Bossemeyer; Volker Kinzel; Jennifer Reed
Influence of myristoylation, phosphorylation, and deamidation on the structural behavior of the N-terminus of the catalytic subunit of cAMP-dependent protein kinase.
Biochemistry 2001;40(1):225-31.
2000: Volker Kinzel; Norbert König; Rüdiger Pipkorn; Dirk Bossemeyer; Wolf D Lehmann
The amino terminus of PKA catalytic subunit--a site for introduction of posttranslational heterogeneities by deamidation: D-Asp2 and D-isoAsp2 containing isozymes.
Protein science : a publication of the Protein Society 2000;9(11):2269-77.
2000: Wolf D Lehmann; Andreas Schlosser; Gerhard Erben; Rüdiger Pipkorn; Dirk Bossemeyer; Volker Kinzel
Analysis of isoaspartate in peptides by electrospray tandem mass spectrometry.
Protein science : a publication of the Protein Society 2000;9(11):2260-8.
2000: S Thullner; F Gesellchen; S Wiemann; Walter Pyerin; Volker Kinzel; Dirk Bossemeyer
The protein kinase A catalytic subunit Cbeta2: molecular characterization and distribution of the splice variant.
The Biochemical journal 2000;351(Pt 1):123-32.
2000: Rainer Pepperkok; A Hotz-Wagenblatt; Norbert König; Anne Girod; Dirk Bossemeyer; Volker Kinzel
Intracellular distribution of mammalian protein kinase A catalytic subunit altered by conserved Asn2 deamidation.
The Journal of cell biology 2000;148(4):715-26.
1999: K Crusius; Marietta Kaszkin; Volker Kinzel; Angel Alonso
The human papillomavirus type 16 E5 protein modulates phospholipase C-gamma-1 activity and phosphatidyl inositol turnover in mouse fibroblasts.
Oncogene 1999;18(48):6714-8.
1999: A Tholey; A Lindemann; Volker Kinzel; Jennifer Reed
Direct effects of phosphorylation on the preferred backbone conformation of peptides: a nuclear magnetic resonance study.
Biophysical journal 1999;76(1 Pt 1):76-87.
1998: P T Jedrzejewski; Anne Girod; A Tholey; Norbert König; S Thullner; Volker Kinzel; Dirk Bossemeyer
A conserved deamidation site at Asn 2 in the catalytic subunit of mammalian cAMP-dependent protein kinase detected by capillary LC-MS and tandem mass spectrometry.
Protein science : a publication of the Protein Society 1998;7(2):457-69.
1997: L Prade; Richard A Engh; Anne Girod; Volker Kinzel; Robert Huber; Dirk Bossemeyer
Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential.
Structure (London, England : 1993) 1997;5(12):1627-37.
1997: A Lindemann; Volker Kinzel; Paul Rösch; Jennifer Reed
Structure of the LAV6 peptide: a nucleation site for the correct receptor-induced refolding of the CD4-binding domain of HIV1 gp 120.
Proteins 1997;29(2):203-11.
1997: S Klein; Marietta Kaszkin; H Barth; Volker Kinzel
Signal transduction through epidermal growth factor receptor is altered in HeLa monolayer cells during mitosis.
The Biochemical journal 1997;322 ( Pt 3)():937-46.
1996: Stefan Wiemann; B Steuer; Angel Alonso; Volker Kinzel; Walter Pyerin
Promoter of the gene encoding the bovine catalytic subunit of cAMP-dependent protein kinase isoform C beta 2.
Biochimica et biophysica acta 1996;1309(3):211-20.
1996: Richard A Engh; Anne Girod; Volker Kinzel; Robert Huber; Dirk Bossemeyer
Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity.
The Journal of biological chemistry 1996;271(42):26157-64.
1996: H Barth; Ingrid Hoffmann; S Klein; Marietta Kaszkin; J Richards; Volker Kinzel
Role of cdc25-C phosphatase in the immediate G2 delay induced by the exogenous factors epidermal growth factor and phorbolester.
Journal of cellular physiology 1996;168(3):589-99.
1996: Anne Girod; Volker Kinzel; Dirk Bossemeyer
In vivo activation of recombinant cAPK catalytic subunit active site mutants by coexpression of the wild-type enzyme, evidence for intermolecular cotranslational phosphorylation.
FEBS letters 1996;391(1-2):121-5.
1996: H Barth; Ingrid Hoffmann; Volker Kinzel
Radiation with 1 Gy prevents the activation of the mitotic inducers mitosis-promoting factor (MPF) and cdc25-C in HeLa cells.
Cancer research 1996;56(10):2268-72.
1996: L Seidler; Marietta Kaszkin; Volker Kinzel
Primary alcohols and phosphatidylcholine metabolism in rat brain synaptosomal membranes via phospholipase D.
Pharmacology & toxicology 1996;78(4):249-53.
1996: Marietta Kaszkin; J Richards; Volker Kinzel
Phosphatidic acid mobilized by phospholipase D is involved in the phorbol 12-myristate 13-acetate-induced G2 delay of A431 cells.
The Biochemical journal 1996;314 ( Pt 1)():129-38.
1996: A Graf von Stosch; Volker Kinzel; Jennifer Reed
Extension of the polarity-dependent "switch phenomenon" of the gp120 binding domain as a target for antiviral chemotherapy.
Biochemistry 1996;35(2):411-7.
1996: J Walter; Martina Schnölzer; Walter Pyerin; Volker Kinzel; D Kübler
Induced release of cell surface protein kinase yields CK1- and CK2-like enzymes in tandem.
The Journal of biological chemistry 1996;271(1):111-9.
1995: A Graf von Stosch; M A Jiménez; Volker Kinzel; Jennifer Reed
Solvent polarity-dependent structural refolding: a CD and NMR study of a 15 residue peptide.
Proteins 1995;23(2):196-203.
1995: A Graf von Stosch; Volker Kinzel; R Pipkorn; Jennifer Reed
Investigation of the structural components governing the polarity-dependent refolding of a CD4-binding peptide from gp120.
Journal of molecular biology 1995;250(4):507-13.
1995: H Barth; Volker Kinzel
Epidermal growth factor rapidly impairs activation of p34cdc2 protein kinase in HeLa cells at the G2-M boundary.
Journal of cellular physiology 1995;162(1):44-51.
1994: peter Jordan; Hans Heid; Volker Kinzel; D Kübler
Major cell surface-located protein substrates of an ecto-protein kinase are homologs of known nuclear proteins.
Biochemistry 1994;33(49):14696-706.
1994: Jennifer Reed; Volker Kinzel
Inhibitors of the conformational switch involved in CD4 binding by the env glycoprotein gp120 from human immunodeficiency virus type 1 (HIV1).
Biochemistry 1994;33(36):10993-8.
1994: H Barth; Volker Kinzel
Phorbol ester TPA rapidly prevents activation of p34cdc2 histone H1 kinase and concomitantly the transition from G2 phase to mitosis in synchronized HeLa cells.
Experimental cell research 1994;212(2):383-8.
1994: J Walter; Volker Kinzel; D Kübler
Evidence for CKI and CKII at the cell surface.
Cellular & molecular biology research 1994;40(5-6):473-80.
1993: Jennifer Reed; Volker Kinzel
Primary structure elements responsible for the conformational switch in the envelope glycoprotein gp120 from human immunodeficiency virus type 1: LPCR is a motif governing folding.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(14):6761-5.
1993: Dirk Bossemeyer; Richard A Engh; Volker Kinzel; H Ponstingl; Robert Huber
Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).
The EMBO journal 1993;12(3):849-59.
1992: Stefan Wiemann; Volker Kinzel; Walter Pyerin
Cloning of the C alpha catalytic subunit of the bovine cAMP-dependent protein kinase.
Biochimica et biophysica acta 1992;1171(1):93-6.
1992: Marietta Kaszkin; J Richards; Volker Kinzel
Proposed role of phosphatidic acid in the extracellular control of the transition from G2 phase to mitosis exerted by epidermal growth factor in A431 cells.
Cancer research 1992;52(20):5627-34.
1992: K Schiess; Marietta Kaszkin; P Jordan; L Seidler; Volker Kinzel
Mobilization of diacylglycerol in intact HeLa cells by exogenous phospholipase C from Cl. perfringens is accompanied by release of fatty acids including arachidonic acid.
Biochimica et biophysica acta 1992;1137(1):82-94.
1992: Marietta Kaszkin; L Seidler; R Kast; Volker Kinzel
Epidermal-growth-factor-induced production of phosphatidylalcohols by HeLa cells and A431 cells through activation of phospholipase D.
The Biochemical journal 1992;287 ( Pt 1)():51-7.
1992: D Kübler; D Reinhardt; Jennifer Reed; Walter Pyerin; Volker Kinzel
Atrial natriuretic peptide is phosphorylated by intact cells through cAMP-dependent ecto-protein kinase.
European journal of biochemistry / FEBS 1992;206(1):179-86.
1992: P Plein; Marietta Kaszkin; Volker Kinzel
Accumulation of ester- and ether-linked phosphatidates by HeLa cells in response to ionophore A23187 through activation of phospholipase D.
Biological chemistry Hoppe-Seyler 1992;373(3):151-7.
1991: Marietta Kaszkin; Gerhard Fürstenberger; J Richards; L Seidler; Volker Kinzel
A proposed common mechanism by which phorbol esters and epidermal growth factor delay the progression from G2 phase to mitosis of HeLa cells through phospholipid metabolites.
Cancer research 1991;51(16):4328-35.
1991: Stefan Wiemann; H Voss; Volker Kinzel; Walter Pyerin
Rat C alpha catalytic subunit of the cAMP-dependent protein kinase: cDNA sequence and evidence that it is the only isoform expressed in myoblasts.
Biochimica et biophysica acta 1991;1089(2):254-6.
1991: Jennifer Reed; Volker Kinzel
A conformational switch is associated with receptor affinity in peptides derived from the CD4-binding domain of gp120 from HIV I.
Biochemistry 1991;30(18):4521-8.
1991: Stefan Wiemann; Volker Kinzel; Walter Pyerin
Isoform C beta 2, an unusual form of the bovine catalytic subunit of cAMP-dependent protein kinase.
The Journal of biological chemistry 1991;266(8):5140-6.
1991: Marietta Kaszkin; Gerhard Fürstenberger; Volker Kinzel
Interference of xanthate compounds with phorbol ester TPA-induced changes of phospholipid metabolism: inhibition of prostaglandin production.
Biochemical pharmacology 1991;41(2):315-8.
1990: Volker Kinzel; Marietta Kaszkin; A Blume; J Richards
Epidermal growth factor inhibits transiently the progression from G2-phase to mitosis: a receptor-mediated phenomenon in various cells.
Cancer research 1990;50(24):7932-6.
1990: B Färber; Volker Kinzel
Severe chromosomal damage in mammalian cells induced by pulse labeling with small amounts of [3H]thymidine.
Mutation research 1990;245(3):205-9.
1990: B Färber; Volker Kinzel
Distribution of phorbol ester TPA-induced structural chromosomal aberrations in HeLa cells.
Carcinogenesis 1990;11(11):2067-70.
1990: Volker Kinzel; B Färber; R T Petrusevska; Norbert E Fusenig
Cytogenetic effects of phorbol ester tumor promoters: possible role in multistep tumorigenesis.
Progress in clinical and biological research 1990;340D():133-41.
1989: J Reed; J S De Ropp; Jill Trewhella; D B Glass; W K Liddle; E M Bradbury; Volker Kinzel; Donal A Walsh
Conformational analysis of PKI(5-22)amide, the active inhibitory fragment of the inhibitor protein of the cyclic AMP-dependent protein kinase.
The Biochemical journal 1989;264(2):371-80.
1989: B Färber; R T Petrusevska; Norbert E Fusenig; Volker Kinzel
Cytogenetic effects caused by phorbol ester tumor promoters in HeLa cells: mechanistic aspects.
Carcinogenesis 1989;10(12):2345-50.
1989: J Sonka; D Kübler; Volker Kinzel
Phosphorylation by cell surface protein kinase of bovine and human fibrinogen and fibrin.
Biochimica et biophysica acta 1989;997(3):268-77.
1989: D Kübler; Walter Pyerin; O Bill; A Hotz; J Sonka; Volker Kinzel
Evidence for ecto-protein kinase activity that phosphorylates Kemptide in a cyclic AMP-dependent mode.
The Journal of biological chemistry 1989;264(24):14549-55.
1989: A Hotz; N König; H Taniguchi; J C Chrivia; Volker Kinzel
Catalytic subunit of cAMP-dependent protein kinase from bovine heart: several isoforms demonstrated by high resolution focusing in immobilized pH gradient.
Biochemical and biophysical research communications 1989;160(2):596-601.
1988: S M Van Patten; A Hotz; Volker Kinzel; Donal A Walsh
The inhibitor protein of the cyclic AMP-dependent protein kinase-catalytic subunit interaction. Composition of multiple complexes.
The Biochemical journal 1988;256(3):785-9.
1988: Jennifer Reed; William E Hull; Claus-W von der Lieth; D Kübler; S Suhai; Volker Kinzel
Secondary structure of the Arg-Gly-Asp recognition site in proteins involved in cell-surface adhesion. Evidence for the occurrence of nested beta-bends in the model hexapeptide GRGDSP.
European journal of biochemistry / FEBS 1988;178(1):141-54.
1988: Marietta Kaszkin; U Espe; Gerhard Fürstenberger; Volker Kinzel
Dual effect of the phorbol ester TPA on arachidonic acid release from HeLa cells.
FEBS letters 1988;233(2):244-8.
1988: Volker Kinzel; G Bonheim; J Richards
Phorbol ester-induced G2 delay in HeLa cells analyzed by time lapse photography.
Cancer research 1988;48(7):1759-62.
1987: Jennifer Reed; Volker Kinzel; H C Cheng; Donal A Walsh
Circular dichroic investigations of secondary structure in synthetic peptide inhibitors of cAMP-dependent protein kinase: a model for inhibitory potential.
Biochemistry 1987;26(24):7641-7.
1987: Volker Kinzel; Marietta Kaszkin; U Espe; J Richards; Gerhard Fürstenberger
Role of arachidonic acid release in the G2 delay induced by tumor promoter TPA in HeLa cells.
Experimental cell research 1987;173(2):305-10.
1987: D Kübler; M Fehst; T Garcon; Walter Pyerin; E Burow; Volker Kinzel
Substrates for the cell surface protein kinase in blood: a calf serum protein and its precursor in plasma.
Biochemistry international 1987;15(2):349-57.
1987: Volker Kinzel; A Hotz; N König; M Gagelmann; Walter Pyerin; J Reed; D Kübler; F Hofmann; C Obst; H P Gensheimer
Chromatographic separation of two heterogeneous forms of the catalytic subunit of cyclic AMP-dependent protein kinase holoenzyme type I and type II from striated muscle of different mammalian species.
Archives of biochemistry and biophysics 1987;253(2):341-9.
1987: Walter Pyerin; E Burow; K Michaely; D Kübler; Volker Kinzel
Catalytic and molecular properties of highly purified phosvitin/casein kinase type II from human epithelial cells in culture (HeLa) and relation to ecto protein kinase.
Biological chemistry Hoppe-Seyler 1987;368(3):215-27.
1987: U Espe; Gerhard Fürstenberger; F Marks; Marietta Kaszkin; Volker Kinzel
Early changes in the arachidonic acid metabolism of HeLa cells in response to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and related compounds.
Journal of cancer research and clinical oncology 1987;113(2):137-44.
1985: A Faissner; David B Teplow; D Kübler; G Keilhauer; Volker Kinzel; M Schachner
Biosynthesis and membrane topography of the neural cell adhesion molecule L1.
The EMBO journal 1985;4(12):3105-13.
1985: M Fehst; D Kübler; Walter Pyerin; E Burow; Volker Kinzel
Protein kinase activities in mammalian blood fluid.
Biochemical and biophysical research communications 1985;133(1):8-14.
1983: D Kübler; Walter Pyerin; E Burow; Volker Kinzel
Substrate-effected release of surface-located protein kinase from intact cells.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(13):4021-5.
1983: J Reed; M Gagelmann; Volker Kinzel
Isolation and elucidation of some functional properties of the "mute" catalytic subunit of cAMP-dependent protein kinase.
Archives of biochemistry and biophysics 1983;222(1):276-84.
1983: W Pyerin; C R Wolf; Volker Kinzel; D Kübler; F Oesch
Phosphorylation of cytochrome-P-450-dependent monooxygenase components.
Carcinogenesis 1983;4(5):573-6.
1982: D Kübler; Walter Pyerin; Volker Kinzel
Assays of cell surface protein kinase: importance of selecting cytophilic substrates.
European journal of cell biology 1982;26(2):306-9.
1982: D Kübler; Walter Pyerin; Volker Kinzel
Protein kinase activity and substrates at the surface of intact HeLa cells.
The Journal of biological chemistry 1982;257(1):322-9.
1982: D Kübler; W Pyerin; E Burow; T Garcon; Volker Kinzel
Interaction of cells with their proximal environment via surface protein kinase.
Progress in clinical and biological research 1982;102 pt A():499-509.
1980: D Kübler; Walter Pyerin; Volker Kinzel
Generation of pyrophosphate from extracellular ATP at the surface of HeLa cells.
European journal of cell biology 1980;21(2):231-3.
1980: M Gagelmann; Jennifer Reed; D Kübler; Walter Pyerin; Volker Kinzel
Evidence for a "mute" catalytic subunit of cyclic AMP-dependent protein kinase from rat muscle and its mode of activation.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(5):2492-6.