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Kenneth Kinzler

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Patrick J Killela; Kenneth W Kinzler; Nils Mandahl; Roger E McLendon; Alan K Meeker; Fredrik Mertens; GEORGES NETTO; Nickolas Papadopoulos; B Ahmed Rasheed; Zachary J Reitman; Gregory J Riggins; Thomas A Rosenquist; Mark Schiffman; Ie-Ming Shih; Dan Theodorescu; Michael Torbenson; Victor E Velculescu; Bert Vogelstein; Tian-Li Wang; Nicolas Wentzensen; Laura D Wood; Nishant Agrawal; Chetan Bettegowda; Darell D Bigner; Luis Alberto Diaz; Allan H Friedman; Henry Friedman; Gary L Gallia; Beppino C Giovanella; Arthur P Grollman; Tong-Chuan He; Yiping He; Ralph Hruban; George I Jallo; Yuchen Jiao; Ming Zhang; Hai Yan
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.
Chetan Bettegowda; Darell Bigner; Zev A Binder; Gary L Gallia; Ralph H Hruban; George Jallo; Yuchen Jiao; Stephen Keir; Kenneth W Kinzler; Suely Marie; Roger McLendon; Ahmed Rasheed; Zachary J Reitman; Callen J Riggins; Gregory J Riggins; Fausto J Rodriguez; Vafi Salmasi; Sueli Shinjo; Bert Vogelstein; Yuxuan Wang; Laura D Wood; Hai Yan; Nishant Agrawal; Nickolas Papadopoulos
Exomic sequencing of four rare central nervous system tumor types.
Bert Vogelstein; Shibin Zhou; Luis Alberto Diaz; Nickolas Papadopoulos; Victor E Velculescu; Kenneth W Kinzler
Cancer genome landscapes.

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2013: Patrick J Killela; Kenneth W Kinzler; Nils Mandahl; Roger E McLendon; Alan K Meeker; Fredrik Mertens; GEORGES NETTO; Nickolas Papadopoulos; B Ahmed Rasheed; Zachary J Reitman; Gregory J Riggins; Thomas A Rosenquist; Mark Schiffman; Ie-Ming Shih; Dan Theodorescu; Michael Torbenson; Victor E Velculescu; Bert Vogelstein; Tian-Li Wang; Nicolas Wentzensen; Laura D Wood; Nishant Agrawal; Chetan Bettegowda; Darell D Bigner; Luis Alberto Diaz; Allan H Friedman; Henry Friedman; Gary L Gallia; Beppino C Giovanella; Arthur P Grollman; Tong-Chuan He; Yiping He; Ralph Hruban; George I Jallo; Yuchen Jiao; Ming Zhang; Hai Yan
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(15):6021-6.
2013: Chetan Bettegowda; Darell Bigner; Zev A Binder; Gary L Gallia; Ralph H Hruban; George Jallo; Yuchen Jiao; Stephen Keir; Kenneth W Kinzler; Suely Marie; Roger McLendon; Ahmed Rasheed; Zachary J Reitman; Callen J Riggins; Gregory J Riggins; Fausto J Rodriguez; Vafi Salmasi; Sueli Shinjo; Bert Vogelstein; Yuxuan Wang; Laura D Wood; Hai Yan; Nishant Agrawal; Nickolas Papadopoulos
Exomic sequencing of four rare central nervous system tumor types.
Oncotarget 2013;4(4):572-83.
2013: Bert Vogelstein; Shibin Zhou; Luis Alberto Diaz; Nickolas Papadopoulos; Victor E Velculescu; Kenneth W Kinzler
Cancer genome landscapes.
Science (New York, N.Y.) 2013;339(6127):1546-58.
2013: Nishant Agrawal; Chetan Bettegowda; Sheetal Bhan; Justin Bishop; Timothy Chan; Henning Dralle; James A Fagin; Ronald A Ghossein; Allen S Ho; Ralph Hruban; Yuchen Jiao; ZUBAIR KHAN; Kenneth W Kinzler; Rebecca Leary; Luc G T Morris; Barry D Nelkin; Nickolas Papadopoulos; Nicholas J Roberts; Bruce Robinson; Mark Sausen; Rodrigo A Toledo; Sergio P A Toledo; Ralph P Tufano; Victor E Velculescu; Bert Vogelstein; William H Westra; Laura D Wood; Douglas W Ball
Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS.
The Journal of clinical endocrinology and metabolism 2013;98(2):E364-9.
2013: Isaac Kinde; Kenneth W Kinzler; Robert J Kurman; Douglas A Levine; Suely Kazue Nagahashi Marie; Nickolas Papadopoulos; Richard B S Roden; Ie-Ming Shih; Bert Vogelstein; Yuxuan Wang; Jian Wu; Nishant Agrawal; Chetan Bettegowda; Jesus Paula Carvalho; Fanny Dao; James R Eshleman; Robert L Giuntoli; Luis Alberto Diaz
Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers.
Science translational medicine 2013;5(167):167ra4.
2013: Mark Sausen; Victor E Velculescu; Bert Vogelstein; Jian Wu; Siân Jones; Kenneth W Kinzler; Rebecca J Leary; Xueyuan Liu; Nickolas Papadopoulos; Giovanni Parmigiani; C Patrick Reynolds; Amanda Blackford; Luis Alberto Diaz; Michael D Hogarty
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Nature genetics 2013;45(1):12-7.
2012: Yunfeng Cui; Luis Alberto Diaz; Amanda L Blackford; Jacqueline A Brosnan; Ralph Hruban; Christine A Iacobuzio-Donahue; Kenneth W Kinzler; Anirban Maitra; Surojit Sur; Bert Vogelstein; James R Eshleman
Genetically defined subsets of human pancreatic cancer show unique in vitro chemosensitivity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(23):6519-30.
2012: Rebecca J Leary; Joyce O'Shaughnessy; Nickolas Papadopoulos; Giovanni Parmigiani; Mark Sausen; John D Carpten; David Craig; Luis Alberto Diaz; Isaac Kinde; Kenneth W Kinzler; Bert Vogelstein; Victor E Velculescu
Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing.
Science translational medicine 2012;4(162):162ra154.
2012: Hanno Matthaei; Richard D Schulick; Bert Vogelstein; Jian Wu; N Volkan Adsay; Marco Dal Molin; Marija Debeljak; James R Eshleman; Ralph Hruban; Nora Katabi; Kenneth W Kinzler; David S Klimstra; Philipp Lingohr; Anirban Maitra
GNAS codon 201 mutations are uncommon in intraductal papillary neoplasms of the bile duct.
HPB : the official journal of the International Hepato Pancreato Biliary Association 2012;14(10):677-83.
2012: Nishant Agrawal; Chetan Bettegowda; Yulan Cheng; Stefan David; Susan Hutfless; Yuchen Jiao; Kenneth W Kinzler; Nyan L Latt; Nickolas Papadopoulos; Eun Shin; William S Twaddell; Victor E Velculescu; Bert Vogelstein; Liang Wang; Li-Dong Wang; Yuxuan Wang; Wancai Yang; Meltzer Stephen J.
Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma.
Cancer discovery 2012;2(10):899-905.
2012: Yuchen Jiao; Patrick J Killela; Kenneth W Kinzler; Eric Lipp; Giselle Lopez; Roger McLendon; Alan K Meeker; Sueli M Oba-Shinjo; Nickolas Papadopoulos; Christopher Pirozzi; Ahmed B Rasheed; Zachary J Reitman; Gregory J Riggins; Fausto J Rodriguez; Sergio Rosemberg; Bert Vogelstein; Nishant Agrawal; Chetan Bettegowda; Darell D Bigner; Peter C Burger; Roeland F de Wilde; Luis Alberto Diaz; Allan H Friedman; Henry Friedman; Yiping He; Christopher M Heaphy; Matthias Holdhoff; Suely Kazue Nagahashi Marie; Hai Yan
Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas.
Oncotarget 2012;3(7):709-22.
2012: Luis Alberto Diaz; J Randolph Hecht; Isaac Kinde; Kenneth W Kinzler; Martin A Nowak; Kelly S Oliner; Johannes G Reiter; Benjamin Allen; Jordan Berlin; Ivana Bozic; Richard T Williams; Jian Wu; Bert Vogelstein
The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers.
Nature 2012;486(7404):537-40.
2012: Zhaohua Zheng; Jiuxiang Zhu; Syazwani I Amran; Kenneth W Kinzler; Oleg Schmidt-Kittler; Peter R Shepherd; Philip E Thompson; Bert Vogelstein; Ian G Jennings
Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis.
The Biochemical journal 2012;444(3):529-35.
2012: Melinda D Willard; Isabella H Wulur; Bo Feng; Kenneth W Kinzler; Mary E Lajiness; Sanford D Markowitz; Steven M Powell; Tobias Sjöblom; Michelle L Swearingen; Mark T Uhlik; Victor E Velculescu; Bert Vogelstein; Thomas D Barber
Somatic mutations in CCK2R alter receptor activity that promote oncogenic phenotypes.
Molecular cancer research : MCR 2012;10(6):739-49.
2012: Nicholas J Roberts; Kenneth W Kinzler; Giovanni Parmigiani; Bert Vogelstein; Joshua T Vogelstein; Victor E Velculescu
The predictive capacity of personal genome sequencing.
Science translational medicine 2012;4(133):133ra58.
2012: Mitsuro Kanda; Kenneth W Kinzler; Anirban Maitra; Hanno Matthaei; Bert Vogelstein; Jian Wu; Jun Yu; Michael Borges; Seung-Mo Hong; Ralph Hruban; Michael Goggins
Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia.
Gastroenterology 2012;142(4):730-733.e9.
2012: Bert Vogelstein; Kenneth W Kinzler
Winning the war: science parkour.
Science translational medicine 2012;4(127):127ed2.
2012: Siân Jones; Kenneth W Kinzler; Robert J Kurman; Kentaro Nakayama; Nickolas Papadopoulos; Victor E Velculescu; Bert Vogelstein; Tian-Li Wang; Ie-Ming Shih
Low-grade serous carcinomas of the ovary contain very few point mutations.
The Journal of pathology 2012;226(3):413-20.
2012: David A Ahlquist; Barry M Berger; Niels Chr Bjerregaard; Malinda L Butz; Michael Domanico; Kenneth W Kinzler; Søren Laurberg; Douglas W Mahoney; Lawrence F Paszat; Linda Rabeneck; Henrik Toft Sørensen; William R Taylor; Stephen N Thibodeau; Bert Vogelstein; Tracy Carol Yab; Hongzhi Zou; Graham P Lidgard
Next-generation stool DNA test accurately detects colorectal cancer and large adenomas.
Gastroenterology 2012;142(2):248-56; quiz e25-6.
2012: Courtney A Lovejoy; Neal F Lue; Laura Macconaill; Alan K Meeker; Nickolas Papadopoulos; John H J Petrini; Roger R Reddel; Steven Reisenweber; Joseph Rosenbluh; Patricia A Sung; Supawat Thongthip; Bert Vogelstein; Barbara A Weir; Yaara Zwang; Joanne Bruno; Titia de Lange; Saurav De; William C Hahn; Megan Hanna; Charlie Hatton; Elena Ivanova; Maria Jasin; Yuchen Jiao; Kenneth W Kinzler; Wendi Li
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.
PLoS genetics 2012;8(7):e1002772.
2012: Isaac Kinde; Kenneth W Kinzler; Nickolas Papadopoulos; Bert Vogelstein
FAST-SeqS: a simple and efficient method for the detection of aneuploidy by massively parallel sequencing.
PloS one 2012;7(7):e41162.
2012: Nicholas J Roberts; Richard D Schulick; Ann Grossbart Schwartz; Sapna Syngal; Victor E Velculescu; Bert Vogelstein; Jun Yu; Levy Kopelovich; Nickolas Papadopoulos; Gloria M Petersen; Syed Z Ali; Jennifer E Axilbund; Melissa L Bondy; Michele Cote; James R Eshleman; Steven Gallinger; Michael Goggins; Ralph Hruban; Yuchen Jiao; Kenneth W Kinzler; Alison P Klein
ATM mutations in patients with hereditary pancreatic cancer.
Cancer discovery 2012;2(1):41-6.
2012: Erika L Krick; Kenneth W Kinzler; Shelley Rankin; Karin U Sorenmo; KATHERINE THORNTON; Shibin Zhou; Bert Vogelstein; BARRY KOBRIN; Ian Cheong; Luis Alberto Diaz
Evaluation of Clostridium novyi-NT spores in dogs with naturally occurring tumors.
American journal of veterinary research 2012;73(1):112-8.
2012: Siân Jones; Xiaosong Zhang; Hai Yan; James R Eshleman; Petra Kristel; Bert Vogelstein; Michael Goggins; Steve Powell; Jelle Wesseling; Marjanka K Schmidt; Anirban Maitra; DONALD PARSONS; Sami Malek; Christine A Iacobuzio-Donahue; Darell Bigner; Ralph Hruban; Meng Li; Sanford Markowitz; Kenneth W Kinzler; Victor E Velculescu; Nickolas Papadopoulos
Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types.
Human mutation 2012;33(1):100-3.
2011: Jian Wu; Marcia Canto; James R Eshleman; Michael A Choti; Hannah Carter; G Johan A Offerhaus; Marco Dal Molin; Nickolas Papadopoulos; Laura D Wood; Anirban Maitra; Yuchen Jiao; C Max Schmidt; Kenneth W Kinzler; Rachel Karchin; Volkan Adsay; Alison P Klein; Yoshiki Naito; Michael Goggins; Richard D Schulick; Roeland F de Wilde; Christopher L Wolfgang; David S Klimstra; BARISH EDIL; Luis Alberto Diaz; Levy Kopelovich; Ralph Hruban; Peter J Allen; Bert Vogelstein
Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(52):21188-93.
2011: X Zhang; H Carter; Kenneth W Kinzler; Y Li; P Ouillette; M Reis; Nickolas Papadopoulos; R Karchin; Bert Vogelstein; Victor E Velculescu; J Samayoa; M Li; R Khoriaty; Luis Alberto Diaz; Sami Malek
Sequence analysis of 515 kinase genes in chronic lymphocytic leukemia.
Leukemia 2011;25(12):1908-10.
2011: Meng Li; Peter Ouillette; Nickolas Papadopoulos; Bert Vogelstein; Dale Bixby; Roxane Collins; Harry P Erba; Yuchen Jiao; Kenneth W Kinzler; Sami Malek
Somatic mutations in the transcriptional corepressor gene BCORL1 in adult acute myelogenous leukemia.
Blood 2011;118(22):5914-7.
2011: Chetan Bettegowda; Darell Bigner; Daniel P Cahill; Ralph Hruban; Yuchen Jiao; Nishant Agrawal; Suely Kazue Nagahashi Marie; Roger McLendon; Sueli M Oba-Shinjo; Nickolas Papadopoulos; Gregory J Riggins; Fausto J Rodriguez; Mark Sausen; Victor E Velculescu; Bert Vogelstein; Laura D Wood; Hai Yan; Kenneth W Kinzler
Mutations in CIC and FUBP1 contribute to human oligodendroglioma.
Science (New York, N.Y.) 2011;333(6048):1453-5.
2011: Meng Li; G Johan A Offerhaus; Nickolas Papadopoulos; Timothy M Pawlik; Michael Torbenson; Victor E Velculescu; Bert Vogelstein; Linfang Wang; Laura D Wood; Xiaosong Zhang; Hong Zhao; Shibin Zhou; Robert A Anders; Jianqiang Cai; Michael A Choti; Hubert D Daniel; Ralph Hruban; Rajesh Kannangai; Kenneth W Kinzler
Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma.
Nature genetics 2011;43(9):828-9.
2011: Nishant Agrawal; Chetan Bettegowda; Joseph A Califano; Kyle Chang; Jennifer A Drummond; Adel K El-Naggar; Carole Fakhry; Mitchell J Frederick; Richard A Gibbs; Ralph Hruban; Samar A Jasser; Kenneth W Kinzler; Wayne M Koch; Ryan J Li; Donna M Muzny; Nickolas Papadopoulos; Curtis R Pickering; David Sidransky; Lisa Treviño; Victor E Velculescu; Bert Vogelstein; Jing Wang; John N Weinstein; William H Westra; David A Wheeler; Laura D Wood; Yuanqing Wu; Tong-Xin Xie; Jiexin Zhang; Nianxiang Zhang; Jeffrey N Myers
Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1.
Science (New York, N.Y.) 2011;333(6046):1154-7.
2011: Christopher M Heaphy; Sachidanand Hebbar; Ralph Hruban; Yuchen Jiao; Kenneth W Kinzler; Alison P Klein; Anirban Maitra; Suely Kazue Nagahashi Marie; Roger McLendon; Sueli M Oba-Shinjo; G Johan A Offerhaus; Nickolas Papadopoulos; B Ahmed Rasheed; Gregory J Riggins; Fausto J Rodriguez; Chanjuan Shi; Bert Vogelstein; Hai Yan; Chetan Bettegowda; Darell D Bigner; Roeland F de Wilde; Charles G Eberhart; BARISH EDIL; Yiping He; Alan K Meeker
Altered telomeres in tumors with ATRX and DAXX mutations.
Science (New York, N.Y.) 2011;333(6041):425.
2011: Jian Wu; Christopher L Wolfgang; Laura D Wood; Peter J Allen; Marcia Canto; Marco Dal Molin; Luis Alberto Diaz; BARISH EDIL; James R Eshleman; Michael Goggins; Ralph Hruban; Kenneth W Kinzler; Alison P Klein; Anirban Maitra; Hanno Matthaei; Nickolas Papadopoulos; C Max Schmidt; Richard D Schulick; Bert Vogelstein
Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development.
Science translational medicine 2011;3(92):92ra66.
2011: Isaac Kinde; Kenneth W Kinzler; Nickolas Papadopoulos; Jian Wu; Bert Vogelstein
Detection and quantification of rare mutations with massively parallel sequencing.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(23):9530-5.
2011: Matthias Holdhoff; Kerstin Schmidt; Frank Diehl; Nishant Aggrawal; Philipp Angenendt; Katharine E Romans; daniel edelstein; Michael Torbenson; Kenneth W Kinzler; Bert Vogelstein; Michael A Choti; Luis Alberto Diaz
Detection of tumor DNA at the margins of colorectal cancer liver metastasis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(11):3551-7.
2011: Jo-Anne Pinson; Oleg Schmidt-Kittler; Jiuxiang Zhu; Ian G Jennings; Kenneth W Kinzler; Bert Vogelstein; David K Chalmers; Philip E Thompson
Thiazolidinedione-based PI3Kα inhibitors: an analysis of biochemical and virtual screening methods.
ChemMedChem 2011;6(3):514-22.
2011: Yuchen Jiao; Chanjuan Shi; BARISH EDIL; Roeland F de Wilde; David S Klimstra; Anirban Maitra; Richard D Schulick; Laura H Tang; Christopher L Wolfgang; Michael A Choti; Victor E Velculescu; Luis Alberto Diaz; Bert Vogelstein; Kenneth W Kinzler; Ralph Hruban; Nickolas Papadopoulos
DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.
Science (New York, N.Y.) 2011;331(6021):1199-203.
2011: Jian He; Jian Wu; Yuchen Jiao; Nina Wagner-Johnston; Richard F Ambinder; Luis Alberto Diaz; Kenneth W Kinzler; Bert Vogelstein; Nickolas Papadopoulos
IgH gene rearrangements as plasma biomarkers in Non- Hodgkin's lymphoma patients.
Oncotarget 2011;2(3):178-85.
2011: Zachary J Reitman; Genglin Jin; Edward D Karoly; Ivan Spasojevic; Jian Yang; Kenneth W Kinzler; Yiping He; Darell D Bigner; Bert Vogelstein; Hai Yan
Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(8):3270-5.
2011: Qing Wang; Raghothama Chaerkady; Jian Wu; Hee Jung Hwang; Nickolas Papadopoulos; Levy Kopelovich; Anirban Maitra; Hanno Matthaei; James R Eshleman; Ralph Hruban; Kenneth W Kinzler; Akhilesh Pandey; Bert Vogelstein
Mutant proteins as cancer-specific biomarkers.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(6):2444-9.
2011: DONALD PARSONS; Meng Li; Xiaosong Zhang; Siân Jones; Rebecca J Leary; Jimmy Cheng-Ho Lin; Simina M Boca; Hannah Carter; Josue Samayoa; Chetan Bettegowda; Gary L Gallia; George I Jallo; Zev A Binder; Yuri Nikolsky; James Hartigan; Doug R Smith; Daniela S Gerhard; Daniel W Fults; Scott VandenBerg; Mitchel S Berger; Suely Kazue Nagahashi Marie; Sueli Mieko Oba Shinjo; Carlos Clara; Peter C Phillips; Jane E Minturn; Jaclyn A Biegel; Alexander R Judkins; Adam C Resnick; Phillip B Storm; Tom Curran; Yiping He; B Ahmed Rasheed; Henry S Friedman; Stephen T Keir; Roger McLendon; Paul A Northcott; Michael D Taylor; Peter C Burger; Gregory J Riggins; Rachel Karchin; Giovanni Parmigiani; Darell D Bigner; Hai Yan; Nickolas Papadopoulos; Bert Vogelstein; Kenneth W Kinzler; Victor E Velculescu
The genetic landscape of the childhood cancer medulloblastoma.
Science (New York, N.Y.) 2011;331(6016):435-9.
2011: Yuan Qiao; Xin Huang; Sridhar Nimmagadda ; RENYUAN BAI; Verena Staedtke; Catherine A Foss; Ian Cheong; Matthias Holdhoff; Yoshinori Kato; Martin G Pomper; Gregory J Riggins; Kenneth W Kinzler; Luis Alberto Diaz; Bert Vogelstein; Shibin Zhou
A robust approach to enhance tumor-selective accumulation of nanoparticles.
Oncotarget 2011;2(1-2):59-68.
2010: Shinichi Yachida; Siân Jones; Ivana Bozic; Tibor Antal; Rebecca Leary; BAOJIN FU; Mihoko Kamiyama; Ralph Hruban; James R Eshleman; Martin A Nowak; Victor E Velculescu; Kenneth W Kinzler; Bert Vogelstein; Christine A Iacobuzio-Donahue
Distant metastasis occurs late during the genetic evolution of pancreatic cancer.
Nature 2010;467(7319):1114-7.
2010: Ivana Bozic; Tibor Antal; Hisashi Ohtsuki; Hannah Carter; Dewey Kim; Sining Chen; Rachel Karchin; Kenneth W Kinzler; Bert Vogelstein; Martin A Nowak
Accumulation of driver and passenger mutations during tumor progression.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(43):18545-50.
2010: Siân Jones; Tian-Li Wang; Ie-Ming Shih; Tsui-Lien Mao; Kentaro Nakayama; Richard B S Roden; Ruth Glas; Dennis J Slamon; Luis Alberto Diaz; Bert Vogelstein; Kenneth W Kinzler; Victor E Velculescu; Nickolas Papadopoulos
Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma.
Science (New York, N.Y.) 2010;330(6001):228-31.
2010: Oleg Schmidt-Kittler; Jiuxiang Zhu; Jian Yang; Guosheng Liu; William Hendricks; Christoph Lengauer; Sandra B. Gabelli; Kenneth W Kinzler; Bert Vogelstein; David L Huso; Shibin Zhou
PI3Kα inhibitors that inhibit metastasis.
Oncotarget 2010;1(5):339-48.
2010: Yiping He; Jian Wu; Devin C Dressman; Christine A Iacobuzio-Donahue; Sanford D Markowitz; Victor E Velculescu; Luis Alberto Diaz; Kenneth W Kinzler; Bert Vogelstein; Nickolas Papadopoulos
Heteroplasmic mitochondrial DNA mutations in normal and tumour cells.
Nature 2010;464(7288):610-4.
2010: Rebecca J Leary; Isaac Kinde; Frank Diehl; Kerstin Schmidt; Chris Clouser; Cisilya Duncan; Alena Antipova; Clarence Lee; Kevin McKernan; Francisco M De La Vega; Kenneth W Kinzler; Bert Vogelstein; Luis Alberto Diaz; Victor E Velculescu
Development of personalized tumor biomarkers using massively parallel sequencing.
Science translational medicine 2010;2(20):20ra14.
2010: Kajsa Ericson; Christine Gan; Ian Cheong; Carlo Rago; Yardena Samuels; Victor E Velculescu; Kenneth W Kinzler; David L Huso; Bert Vogelstein; Nickolas Papadopoulos
Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(6):2598-603.
2010: Simina M Boca; Kenneth W Kinzler; Victor E Velculescu; Bert Vogelstein; Giovanni Parmigiani
Patient-oriented gene set analysis for cancer mutation data.
Genome biology 2010;11(11):R112.
2009: Diana Mandelker; Sandra B. Gabelli; Oleg Schmidt-Kittler; Jiuxiang Zhu; Ian Cheong; Chuan-Hsiang Huang; Kenneth W Kinzler; Bert Vogelstein; Mario Amzel
A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(40):16996-7001.
2009: Jihye Yun; Carlo Rago; Ian Cheong; Ray Pagliarini; Philipp Angenendt; Harith Rajagopalan; Kerstin Schmidt; James Willson; Sanford Markowitz; Shibin Zhou; Luis Alberto Diaz; Victor E Velculescu; Christoph Lengauer; Kenneth W Kinzler; Bert Vogelstein; Nickolas Papadopoulos
Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells.
Science (New York, N.Y.) 2009;325(5947):1555-9.
2009: Meng Li; Wei-Dong Chen; Nickolas Papadopoulos; Steven Goodman; Niels Christian Bjerregaard; Søren Laurberg; Bernard Levin; Hartmut Juhl; Nadir Arber; Helen Moinova; Kris Durkee; Kerstin Schmidt; Yiping He; Frank Diehl; Victor E Velculescu; Shibin Zhou; Luis Alberto Diaz; Kenneth W Kinzler; Sanford D Markowitz; Bert Vogelstein
Sensitive digital quantification of DNA methylation in clinical samples.
Nature biotechnology 2009;27(9):858-63.
2009: Hannah Carter; Sining Chen; Leyla Isik; Svitlana Tyekucheva; Victor E Velculescu; Kenneth W Kinzler; Bert Vogelstein; Rachel Karchin
Cancer-specific high-throughput annotation of somatic mutations: computational prediction of driver missense mutations.
Cancer research 2009;69(16):6660-7.
2009: Kishore Guda; Helen Moinova; Jian He; Oliver Jamison; Lakshmeswari Ravi; Leanna Natale; James Lutterbaugh; Earl Lawrence; Susan Lewis; James Willson; John B Lowe; Georgia L Wiesner; Giovanni Parmigiani; Jill S Barnholtz-Sloan; Dawn W Dawson; Victor E Velculescu; Kenneth W Kinzler; Nickolas Papadopoulos; Bert Vogelstein; Joseph Willis; Thomas A Gerken; Sanford D Markowitz
Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(31):12921-5.
2009: Amanda Blackford; Oscar K Serrano; Christopher L Wolfgang; Giovanni Parmigiani; Siân Jones; Xiaosong Zhang; DONALD PARSONS; Jimmy Cheng-Ho Lin; Rebecca J Leary; James R Eshleman; Michael Goggins; Elizabeth M Jaffee; Christine A Iacobuzio-Donahue; Anirban Maitra; John L Cameron; Kelly Olino; Richard D Schulick; Jordan Winter; JOSEPH HERMAN; Daniel Laheru; Alison P Klein; Bert Vogelstein; Kenneth W Kinzler; Victor E Velculescu; Ralph Hruban
SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(14):4674-9.
2009: Amanda Blackford; Giovanni Parmigiani; Thomas W Kensler; Christopher L Wolfgang; Siân Jones; Xiaosong Zhang; DONALD PARSONS; Jimmy Cheng-Ho Lin; Rebecca J Leary; James R Eshleman; Michael Goggins; Elizabeth M Jaffee; Christine A Iacobuzio-Donahue; Anirban Maitra; Alison P Klein; John L Cameron; Kelly Olino; Richard D Schulick; Jordan Winter; Bert Vogelstein; Victor E Velculescu; Kenneth W Kinzler; Ralph Hruban
Genetic mutations associated with cigarette smoking in pancreatic cancer.
Cancer research 2009;69(8):3681-8.
2009: Siân Jones; Ralph Hruban; Mihoko Kamiyama; Michael Borges; Xiaosong Zhang; DONALD PARSONS; Jimmy Cheng-Ho Lin; Emily Palmisano; Kieran Brune; Elizabeth M Jaffee; Christine A Iacobuzio-Donahue; Anirban Maitra; Giovanni Parmigiani; Scott E Kern; Victor E Velculescu; Kenneth W Kinzler; Bert Vogelstein; James R Eshleman; Michael Goggins; Alison P Klein
Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene.
Science (New York, N.Y.) 2009;324(5924):217.
2009: Surojit Sur; Raymond Pagliarini; Fred Bunz; Carlo Rago; Luis Alberto Diaz; Kenneth W Kinzler; Bert Vogelstein; Nickolas Papadopoulos
A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(10):3964-9.
2009: Hai Yan; DONALD PARSONS; Genglin Jin; Roger McLendon; B Ahmed Rasheed; Weishi Yuan; Ivan Kos; Ines Batinic-Haberle; Siân Jones; Gregory J Riggins; Henry Friedman; Allan Friedman; David Reardon; James Herndon; Kenneth W Kinzler; Victor E Velculescu; Bert Vogelstein; Darell D Bigner
IDH1 and IDH2 mutations in gliomas.
The New England journal of medicine 2009;360(8):765-73.
2009: Christopher G Duncan; Rebecca J Leary; Jimmy Cheng-Ho Lin; Jordan Cummins; Chunhui Di; Carl F Schaefer; Tian-Li Wang; Gregory J Riggins; Jennifer Edwards; Darell Bigner; Levy Kopelovich; Bert Vogelstein; Kenneth W Kinzler; Victor E Velculescu; Hai Yan
Identification of microbial DNA in human cancer.
BMC medical genomics 2009;2():22.
2009: Giovanni Parmigiani; Simina Boca; Jimmy Lin; Kenneth W Kinzler; Victor E Velculescu; Bert Vogelstein
Design and analysis issues in genome-wide somatic mutation studies of cancer.
Genomics 2009;93(1):17-21.
2008: Yiping He; Bert Vogelstein; Victor E Velculescu; Nickolas Papadopoulos; Kenneth W Kinzler
The antisense transcriptomes of human cells.
Science (New York, N.Y.) 2008;322(5909):1855-7.
2008: Rebecca J Leary; Jimmy C Lin; Jordan Cummins; Simina Boca; Laura D Wood; DONALD PARSONS; Siân Jones; Tobias Sjöblom; Ben Ho Park; Ramon Parsons; Joseph Willis; Dawn Dawson; James Willson; Tatiana Nikolskaya; Yuri Nikolsky; Levy Kopelovich; Nickolas Papadopoulos; Len A Pennacchio; Tian-Li Wang; Sanford D Markowitz; Giovanni Parmigiani; Kenneth W Kinzler; Bert Vogelstein; Victor E Velculescu
Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(42):16224-9.
2008: Siân Jones; Xiaosong Zhang; DONALD PARSONS; Jimmy Cheng-Ho Lin; Rebecca J Leary; Philipp Angenendt; Parminder Mankoo; Hannah Carter; Hirohiko Kamiyama; Antonio Jimeno; Seung-Mo Hong; BAOJIN FU; Ming-Tseh Lin; Eric S Calhoun; Mihoko Kamiyama; Kimberly Walter; Tatiana Nikolskaya; Yuri Nikolsky; James Hartigan; Douglas R Smith; Manuel Hidalgo; Steven D Leach; Alison P Klein; Elizabeth M Jaffee; Michael Goggins; Anirban Maitra; Christine A Iacobuzio-Donahue; James R Eshleman; Scott E Kern; Ralph Hruban; Rachel Karchin; Nickolas Papadopoulos; Giovanni Parmigiani; Bert Vogelstein; Victor E Velculescu; Kenneth W Kinzler
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.
Science (New York, N.Y.) 2008;321(5897):1801-6.
2008: DONALD PARSONS; Siân Jones; Xiaosong Zhang; Jimmy Cheng-Ho Lin; Rebecca J Leary; Philipp Angenendt; Parminder Mankoo; Hannah Carter; I-Mei Siu; Gary L Gallia; Alessandro Olivi; Roger McLendon; B Ahmed Rasheed; Stephen Keir; Tatiana Nikolskaya; Yuri Nikolsky; Dana A Busam; Hanna Tekleab; Luis Alberto Diaz; James Hartigan; Doug R Smith; Robert L Strausberg; Suely Kazue Nagahashi Marie; Sueli Mieko Oba Shinjo; Hai Yan; Gregory J Riggins; Darell D Bigner; Rachel Karchin; Nickolas Papadopoulos; Giovanni Parmigiani; Bert Vogelstein; Victor E Velculescu; Kenneth W Kinzler
An integrated genomic analysis of human glioblastoma multiforme.
Science (New York, N.Y.) 2008;321(5897):1807-12.
2008: Mark Frazzetto; Cenk Suphioglu; Jiuxiang Zhu; Oleg Schmidt-Kittler; Ian G Jennings; Susan L Cranmer; Shaun P Jackson; Kenneth W Kinzler; Bert Vogelstein; Philip E Thompson
Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket.
The Biochemical journal 2008;414(3):383-90.
2008: Frank Diehl; Kerstin Schmidt; Michael A Choti; Katharine E Romans; Steven Goodman; Meng Li; KATHERINE THORNTON; Nishant Agrawal; Lori J Sokoll; Stephen Szabo; Kenneth W Kinzler; Bert Vogelstein; Luis Alberto Diaz
Circulating mutant DNA to assess tumor dynamics.
Nature medicine 2008;14(9):985-90.
2008: Frank Diehl; Kerstin Schmidt; Kristine H Durkee; Kent J Moore; Steven Goodman; Anthony P Shuber; Kenneth W Kinzler; Bert Vogelstein
Analysis of mutations in DNA isolated from plasma and stool of colorectal cancer patients.
Gastroenterology 2008;135(2):489-98.
2008: Siân Jones; Wei-Dong Chen; Giovanni Parmigiani; Frank Diehl; Niko Beerenwinkel; Tibor Antal; Arne Traulsen; Martin A Nowak; Christopher Siegel; Victor E Velculescu; Kenneth W Kinzler; Bert Vogelstein; Joseph Willis; Sanford D Markowitz
Comparative lesion sequencing provides insights into tumor evolution.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(11):4283-8.
2008: Thomas D Barber; Kirk McManus; Karen W Y Yuen; Marcelo Reis; Giovanni Parmigiani; Dong Shen; Irene Barrett; Yasaman Nouhi; Forrest Spencer; Sanford Markowitz; Victor E Velculescu; Kenneth W Kinzler; Bert Vogelstein; Christoph Lengauer; Philip Hieter
Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(9):3443-8.
2008: Neil H Segal; DONALD PARSONS; Karl S Peggs; Victor E Velculescu; Kenneth W Kinzler; Bert Vogelstein; James P Allison
Epitope landscape in breast and colorectal cancer.
Cancer research 2008;68(3):889-92.
2007: Chuan-Hsiang Huang; Diana Mandelker; Oleg Schmidt-Kittler; Yardena Samuels; Victor E Velculescu; Kenneth W Kinzler; Bert Vogelstein; Sandra B. Gabelli; Mario Amzel
The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.
Science (New York, N.Y.) 2007;318(5857):1744-8.
2007: Laura D Wood; DONALD PARSONS; Siân Jones; Jimmy Lin; Tobias Sjöblom; Rebecca J Leary; Dong Shen; Simina M Boca; Thomas Barber; Janine Ptak; Natalie Silliman; Stephen Szabo; Zoltan Dezso; Vadim Ustyanksky; Tatiana Nikolskaya; Yuri Nikolsky; Rachel Karchin; Paul A Wilson; Joshua S Kaminker; Zemin Zhang; Randal L. Croshaw; Joseph Willis; Dawn Dawson; Michail Shipitsin; James Willson; Saraswati Sukumar; Kornelia Polyak; Ben Ho Park; Charit L Pethiyagoda; P V Krishna Pant; Dennis G Ballinger; Andrew B Sparks; James Hartigan; Douglas R Smith; Erick Suh; Nickolas Papadopoulos; Phillip Buckhaults; Sanford D Markowitz; Giovanni Parmigiani; Kenneth W Kinzler; Victor E Velculescu; Bert Vogelstein
The genomic landscapes of human breast and colorectal cancers.
Science (New York, N.Y.) 2007;318(5853):1108-13.
2007: Niko Beerenwinkel; Tibor Antal; David Dingli; Arne Traulsen; Kenneth W Kinzler; Victor E Velculescu; Bert Vogelstein; Martin A Nowak
Genetic progression and the waiting time to cancer.
PLoS computational biology 2007;3(11):e225.
2007: Carlo Rago; David L Huso; Frank Diehl; Baktiar O Karim; Guosheng Liu; Nickolas Papadopoulos; Yardena Samuels; Victor E Velculescu; Bert Vogelstein; Kenneth W Kinzler; Luis Alberto Diaz
Serial assessment of human tumor burdens in mice by the analysis of circulating DNA.
Cancer research 2007;67(19):9364-70.
2007: Jimmy Lin; Christine M Gan; Xiaosong Zhang; Siân Jones; Tobias Sjöblom; Laura D Wood; DONALD PARSONS; Nickolas Papadopoulos; Kenneth W Kinzler; Bert Vogelstein; Giovanni Parmigiani; Victor E Velculescu
A multidimensional analysis of genes mutated in breast and colorectal cancers.
Genome research 2007;17(9):1304-18.
2007: Marco Plomp; J Michael McCaffery; Ian Cheong; Xin Huang; Chetan Bettegowda; Kenneth W Kinzler; Shibin Zhou; Bert Vogelstein; Alexander J Malkin
Spore coat architecture of Clostridium novyi NT spores.
Journal of bacteriology 2007;189(17):6457-68.
2007: Victor E Velculescu; Kenneth W Kinzler
Gene expression analysis goes digital.
Nature biotechnology 2007;25(8):878-80.
2007: Xiaodong Zhang; Ailan Guo; Jianshi Yu; Anthony Possemato; Yueting Chen; Weiping Zheng; Roberto D Polakiewicz; Kenneth W Kinzler; Bert Vogelstein; Victor E Velculescu; Zhenghe Wang
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):4060-4.
2007: Brock A Peters; Brad St Croix; Tobias Sjöblom; Jordan M Cummins; Natalie Silliman; Janine Ptak; Saurabh Saha; Kenneth W Kinzler; Christos Hatzis; Victor E Velculescu
Large-scale identification of novel transcripts in the human genome.
Genome research 2007;17(3):287-92.
2007: Kristina Lagerstedt Robinson; Tao Liu; Jana Vandrovcova; Britta Halvarsson; Mark Clendenning; Thierry Frebourg; Nickolas Papadopoulos; Kenneth W Kinzler; Bert Vogelstein; Päivi Peltomäki; Richard D Kolodner; Mef Nilbert; Annika Lindblom
Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnostics.
Journal of the National Cancer Institute 2007;99(4):291-9.
2007: Luis A Diaz; Catherine A Foss; KATHERINE THORNTON; Sridhar Nimmagadda ; Christopher J Endres; Ovsev Uzuner; Thorsten M Seyler; Slif D Ulrich; Janet Conway; Chetan Bettegowda; Nishant Agrawal; Ian Cheong; Xiaosong Zhang; Paul W Ladenson; Luis Alberto Diaz; Michael A Mont; Shibin Zhou; Kenneth W Kinzler; Bert Vogelstein; Martin G Pomper
Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT.
PloS one 2007;2(10):e1007.
2007: Jinyong Luo; Zhong-Liang Deng; Xiaoji Luo; Ni Tang; Wen-Xin Song; Jin Chen; Katie A Sharff; Hue H Luu; Rex C Haydon; Kenneth W Kinzler; Bert Vogelstein; Tong-Chuan He
A protocol for rapid generation of recombinant adenoviruses using the AdEasy system.
Nature protocols 2007;2(5):1236-47.
2006: Chetan Bettegowda; Xin Huang; Jimmy Lin; Ian Cheong; Manu Kohli; Stephen Szabo; Xiaosong Zhang; Luis Alberto Diaz; Victor E Velculescu; Giovanni Parmigiani; Kenneth W Kinzler; Bert Vogelstein; Shibin Zhou
The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT.
Nature biotechnology 2006;24(12):1573-80.
2006: Ian Cheong; Xin Huang; Chetan Bettegowda; Luis Alberto Diaz; Kenneth W Kinzler; Shibin Zhou; Bert Vogelstein
A bacterial protein enhances the release and efficacy of liposomal cancer drugs.
Science (New York, N.Y.) 2006;314(5803):1308-11.
2006: Tobias Sjöblom; Siân Jones; Laura D Wood; DONALD PARSONS; Jimmy Lin; Thomas D Barber; Diana Mandelker; Rebecca J Leary; Janine Ptak; Natalie Silliman; Stephen Szabo; Phillip Buckhaults; Christopher Farrell; Paul Meeh; Sanford D Markowitz; Joseph Willis; Dawn Dawson; James Willson; Adi F Gazdar; James Hartigan; Leo Wu; Changsheng Liu; Giovanni Parmigiani; Ben Ho Park; Kurtis E Bachman; Nickolas Papadopoulos; Bert Vogelstein; Kenneth W Kinzler; Victor E Velculescu
The consensus coding sequences of human breast and colorectal cancers.
Science (New York, N.Y.) 2006;314(5797):268-74.
2006: Laura D Wood; Eric S Calhoun; Natalie Silliman; Janine Ptak; Stephen Szabo; Steve M Powell; Gregory J Riggins; Tian-Li Wang; Hai Yan; Adi F Gazdar; Scott E Kern; Len Pennacchio; Kenneth W Kinzler; Bert Vogelstein; Victor E Velculescu
Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers.
Human mutation 2006;27(10):1060-1.
2006: Sining Chen; Wenyi Wang; Shing Lee; Khedoudja Nafa; Johanna Lee; Katharine E Romans; Patrice Watson; Stephen B Gruber; David M Euhus; Kenneth W Kinzler; Jeremy Jass; Steven Gallinger; Noralane M Lindor; Graham Casey; Nathan Ellis; Francis M Giardiello; Kenneth Offit; Giovanni Parmigiani
Prediction of germline mutations and cancer risk in the Lynch syndrome.
JAMA : the journal of the American Medical Association 2006;296(12):1479-87.
2006: Nickolas Papadopoulos; Kenneth W Kinzler; Bert Vogelstein
The role of companion diagnostics in the development and use of mutation-targeted cancer therapies.
Nature biotechnology 2006;24(8):985-95.
2006: Frank Diehl; Meng Li; Yiping He; Kenneth W Kinzler; Bert Vogelstein; Devin Dressman
BEAMing: single-molecule PCR on microparticles in water-in-oil emulsions.
Nature methods 2006;3(7):551-9.
2006: Jordan M Cummins; Yiping He; Rebecca J Leary; Ray Pagliarini; Luis Alberto Diaz; Tobias Sjoblom; Omer Barad; Zvi Bentwich; Anna E Szafranska; Emmanuel Labourier; Christopher K Raymond; Brian S Roberts; Hartmut Juhl; Kenneth W Kinzler; Bert Vogelstein; Victor E Velculescu
The colorectal microRNAome.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(10):3687-92.
2006: Akash Nanda; Baktiar O Karim; Zhongsheng Peng; Guosheng Liu; Weiping Qiu; Christine Gan; Bert Vogelstein; Brad St Croix; Kenneth W Kinzler; David L Huso
Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3351-6.
2006: Meng Li; Frank Diehl; Devin Dressman; Bert Vogelstein; Kenneth W Kinzler
BEAMing up for detection and quantification of rare sequence variants.
Nature methods 2006;3(2):95-7.
2005: Luis Alberto Diaz; Ian Cheong; Catherine A Foss; Xiaosong Zhang; Brock A Peters; Nishant Agrawal; Chetan Bettegowda; Baktiar O Karim; Guosheng Liu; Khalid Khan; Xin Huang; Manu Kohli; Long H Dang; PAUL HWANG; Ahava Vogelstein; Elizabeth Garrett-Mayer; BARRY KOBRIN; Martin G Pomper; Shibin Zhou; Kenneth W Kinzler; Bert Vogelstein; David L Huso
Pharmacologic and toxicologic evaluation of C. novyi-NT spores.
Toxicological sciences : an official journal of the Society of Toxicology 2005;88(2):562-75.
2005: Frank Diehl; Meng Li; Devin Dressman; Yiping He; Dong Shen; Stephen Szabo; Luis Alberto Diaz; Steven Goodman; Kerstin A David; Hartmut Juhl; Kenneth W Kinzler; Bert Vogelstein
Detection and quantification of mutations in the plasma of patients with colorectal tumors.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(45):16368-73.
2005: DONALD PARSONS; Tian-Li Wang; Yardena Samuels; Alberto Bardelli; Jordan M Cummins; Laura DeLong; Natalie Silliman; Janine Ptak; Stephen Szabo; James Willson; Sanford Markowitz; Kenneth W Kinzler; Bert Vogelstein; Christoph Lengauer; Victor E Velculescu
Colorectal cancer: mutations in a signalling pathway.
Nature 2005;436(7052):792.
2005: Amos B Smith; B Scott Freeze; Matthew J LaMarche; Jason Sager; Kenneth W Kinzler; Bert Vogelstein
Discodermolide analogues as the chemical component of combination bacteriolytic therapy.
Bioorganic & medicinal chemistry letters 2005;15(15):3623-6.
2005: Kurtis E Bachman; Jason A Sager; Ian Cheong; Marco Catto; Alberto Bardelli; Ben Ho Park; Bert Vogelstein; Angelo Carotti; Kenneth W Kinzler; Christoph Lengauer
Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine-resistant cancer cells.
Molecular cancer therapeutics 2005;4(6):1026-30.
2005: Yardena Samuels; Luis Alberto Diaz; Oleg Schmidt-Kittler; Jordan M Cummins; Laura Delong; Ian Cheong; Carlo Rago; David L Huso; Christoph Lengauer; Kenneth W Kinzler; Bert Vogelstein; Victor E Velculescu
Mutant PIK3CA promotes cell growth and invasion of human cancer cells.
Cancer cell 2005;7(6):561-73.
2005: Brock A Peters; Luis Alberto Diaz; Kornelia Polyak; Leslie Meszler; Katharine E Romans; Eva C Guinan; Joseph H Antin; David Myerson; Stanley R Hamilton; Bert Vogelstein; Kenneth W Kinzler; Christoph Lengauer
Contribution of bone marrow-derived endothelial cells to human tumor vasculature.
Nature medicine 2005;11(3):261-2.
2005: Chetan Bettegowda; Catherine A Foss; Ian Cheong; Yuchuan Wang; Luis Alberto Diaz; Nishant Agrawal; James Fox; James D Dick; Long H Dang; Shibin Zhou; Kenneth W Kinzler; Bert Vogelstein; Martin G Pomper
Imaging bacterial infections with radiolabeled 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(4):1145-50.
2004: Thomas D Barber; Bert Vogelstein; Kenneth W Kinzler; Victor E Velculescu
Somatic mutations of EGFR in colorectal cancers and glioblastomas.
The New England journal of medicine 2004;351(27):2883.
2004: Akash Nanda; Phillip Buckhaults; Steven Seaman; Nishant Agrawal; Paula Boutin; Srinivas Shankara; Mariana Nacht; Beverly A Teicher; Jason Stampfl; Sujay Singh; Bert Vogelstein; Kenneth W Kinzler; Brad St Croix
Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R.
Cancer research 2004;64(23):8507-11.
2004: Manu Kohli; Jian Yu; Craig Seaman; Alberto Bardelli; Kenneth W Kinzler; Bert Vogelstein; Christoph Lengauer; Lin Zhang
SMAC/Diablo-dependent apoptosis induced by nonsteroidal antiinflammatory drugs (NSAIDs) in colon cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(48):16897-902.
2004: Nishant Agrawal; Chetan Bettegowda; Ian Cheong; Jean-Francois H Geschwind; Charles G Drake; Edward L Hipkiss; Mitsuaki Tatsumi; Long H Dang; Luis Alberto Diaz; Martin G Pomper; Mohammad Abusedera; Richard L Wahl; Kenneth W Kinzler; Shibin Zhou; David L Huso; Bert Vogelstein
Bacteriolytic therapy can generate a potent immune response against experimental tumors.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(42):15172-7.
2004: Bert Vogelstein; Kenneth W Kinzler
Cancer genes and the pathways they control.
Nature medicine 2004;10(8):789-99.
2004: Hallur Gurulingappa; Phillip Buckhalts; Kenneth W Kinzler; Bert Vogelstein; Saeed R Khan
Synthesis and evaluation of aminophosphinic acid derivatives as inhibitors of renal dipeptidase.
Bioorganic & medicinal chemistry letters 2004;14(13):3531-3.
2004: Zhenghe Wang; Dong Shen; DONALD PARSONS; Alberto Bardelli; Jason A Sager; Stephen Szabo; Janine Ptak; Natalie Silliman; Brock A Peters; Michiel S van der Heijden; Giovanni Parmigiani; Hai Yan; Tian-Li Wang; Gregory J Riggins; Steven M Powell; James Willson; Sanford Markowitz; Kenneth W Kinzler; Bert Vogelstein; Victor E Velculescu
Mutational analysis of the tyrosine phosphatome in colorectal cancers.
Science (New York, N.Y.) 2004;304(5674):1164-6.
2004: Jordan M Cummins; Manu Kohli; Carlo Rago; Kenneth W Kinzler; Bert Vogelstein; Fred Bunz
X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells.
Cancer research 2004;64(9):3006-8.
2004: Zhenghe Wang; Jordan M Cummins; Dong Shen; Daniel P Cahill; Prasad V Jallepalli; Tian-Li Wang; DONALD PARSONS; Giovanni Traverso; Mark Awad; Natalie Silliman; Janine Ptak; Stephen Szabo; James Willson; Sanford D Markowitz; Michael L Goldberg; Roger Karess; Kenneth W Kinzler; Bert Vogelstein; Victor E Velculescu; Christoph Lengauer
Three classes of genes mutated in colorectal cancers with chromosomal instability.
Cancer research 2004;64(9):2998-3001.
2004: Yardena Samuels; Zhenghe Wang; Alberto Bardelli; Natalie Silliman; Janine Ptak; Stephen Szabo; Hai Yan; Adi F Gazdar; Steven M Powell; Gregory J Riggins; James Willson; Sanford Markowitz; Kenneth W Kinzler; Bert Vogelstein; Victor E Velculescu
High frequency of mutations of the PIK3CA gene in human cancers.
Science (New York, N.Y.) 2004;304(5670):554.
2004: Jens Koopmann; Phillip Buckhaults; David A Brown; Marianna Zahurak; Norihiro Sato; Noriyoshi Fukushima; Lori J Sokoll; Daniel W Chan; Charles J Yeo; Ralph Hruban; Samuel N Breit; Kenneth W Kinzler; Bert Vogelstein; Michael Goggins
Serum macrophage inhibitory cytokine 1 as a marker of pancreatic and other periampullary cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(7):2386-92.
2004: Jordan M Cummins; Carlo Rago; Manu Kohli; Kenneth W Kinzler; Christoph Lengauer; Bert Vogelstein
Tumour suppression: disruption of HAUSP gene stabilizes p53.
Nature 2004;428(6982):1 p following 486.
2004: Harith Rajagopalan; Prasad V Jallepalli; Carlo Rago; Victor E Velculescu; Kenneth W Kinzler; Bert Vogelstein; Christoph Lengauer
Inactivation of hCDC4 can cause chromosomal instability.
Nature 2004;428(6978):77-81.
2004: Tian-Li Wang; Luis Alberto Diaz; Katharine E Romans; Alberto Bardelli; Saurabh Saha; Gennaro Galizia; Michael A Choti; Ross C Donehower; Giovanni Parmigiani; Ie-Ming Shih; Christine A Iacobuzio-Donahue; Kenneth W Kinzler; Bert Vogelstein; Christoph Lengauer; Victor E Velculescu
Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3089-94.
2004: Long H Dang; Chetan Bettegowda; Nishant Agrawal; Ian Cheong; David L Huso; Philip Frost; Frank Loganzo; Lee M Greenberger; Jozsef Barkoczy; George R Pettit; Amos B Smith; Hallur Gurulingappa; Saeed R Khan; Giovanni Parmigiani; Kenneth W Kinzler; Shibin Zhou; Bert Vogelstein
Targeting vascular and avascular compartments of tumors with C. novyi-NT and anti-microtubule agents.
Cancer biology & therapy 2004;3(3):326-37.
2004: Akash Nanda; Eleanor B Carson-Walter; Steven Seaman; Thomas D Barber; Jason Stampfl; Sujay Singh; Bert Vogelstein; Kenneth W Kinzler; Brad St Croix
TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI).
Cancer research 2004;64(3):817-20.
2004: Manu Kohli; Carlo Rago; Christoph Lengauer; Kenneth W Kinzler; Bert Vogelstein
Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses.
Nucleic acids research 2004;32(1):e3.
2003: Giovanni Traverso; Chetan Bettegowda; Jürgen Kraus; Michael R Speicher; Kenneth W Kinzler; Bert Vogelstein; Christoph Lengauer
Hyper-recombination and genetic instability in BLM-deficient epithelial cells.
Cancer research 2003;63(24):8578-81.
2003: Chetan Bettegowda; Long H Dang; Ross Abrams; David L Huso; Larry E Dillehay; Ian Cheong; Nishant Agrawal; Scott Borzillary; J Michael McCaffery; E Latice Watson; Kuo-Shyan Lin; Fred Bunz; Kwamena Baidoo; Martin G Pomper; Kenneth W Kinzler; Bert Vogelstein; Shibin Zhou
Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteria.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):15083-8.
2003: Suzanne J Baker; Kenneth W Kinzler; Bert Vogelstein
Knudson's hypothesis and the TP53 revolution.
Genes, chromosomes & cancer 2003;38(4):329.
2003: Alberto Bardelli; Saurabh Saha; Jason A Sager; Katharine E Romans; Baozhong Xin; Sanford D Markowitz; Christoph Lengauer; Victor E Velculescu; Kenneth W Kinzler; Bert Vogelstein
PRL-3 expression in metastatic cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(15):5607-15.
2003: Zhenghe Wang; Bert Vogelstein; Kenneth W Kinzler
Phosphorylation of beta-catenin at S33, S37, or T41 can occur in the absence of phosphorylation at T45 in colon cancer cells.
Cancer research 2003;63(17):5234-5.
2003: Giovanni Traverso; Frank Diehl; Robin Hurst; Anthony P Shuber; Duncan Whitney; Constance Johnson; Bernard Levin; Kenneth W Kinzler; Bert Vogelstein
Multicolor in vitro translation.
Nature biotechnology 2003;21(9):1093-7.
2003: Devin Dressman; Hai Yan; Giovanni Traverso; Kenneth W Kinzler; Bert Vogelstein
Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):8817-22.
2003: David A Brown; Robyn L Ward; Phillip Buckhaults; Tao Liu; Katharine E Romans; Nicholas Hawkins; Asne R Bauskin; Kenneth W Kinzler; Bert Vogelstein; Samuel N Breit
MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(7):2642-50.
2003: Alberto Bardelli; DONALD PARSONS; Natalie Silliman; Janine Ptak; Stephen Szabo; Saurabh Saha; Sanford Markowitz; James Willson; Giovanni Parmigiani; Kenneth W Kinzler; Bert Vogelstein; Victor E Velculescu
Mutational analysis of the tyrosine kinome in colorectal cancers.
Science (New York, N.Y.) 2003;300(5621):949.
2003: Jian Yu; Zhenghe Wang; Kenneth W Kinzler; Bert Vogelstein; Lin Zhang
PUMA mediates the apoptotic response to p53 in colorectal cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1931-6.
2003: Kurtis E Bachman; Ben Ho Park; Ina Rhee; Harith Rajagopalan; James G Herman; Stephen B Baylin; Kenneth W Kinzler; Bert Vogelstein
Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene.
Cancer cell 2003;3(1):89-95.
2002: Tian-Li Wang; Christine Maierhofer; Michael R Speicher; Christoph Lengauer; Bert Vogelstein; Kenneth W Kinzler; Victor E Velculescu
Digital karyotyping.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(25):16156-61.
2002: Harith Rajagopalan; Alberto Bardelli; Christoph Lengauer; Kenneth W Kinzler; Bert Vogelstein; Victor E Velculescu
Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status.
Nature 2002;418(6901):934.
2002: Hai Yan; Weishi Yuan; Victor E Velculescu; Bert Vogelstein; Kenneth W Kinzler
Allelic variation in human gene expression.
Science (New York, N.Y.) 2002;297(5584):1143.
2002: Hidewaki Nakagawa; Hai Yan; Janet Lockman; Heather Hampel; Kenneth W Kinzler; Bert Vogelstein; Albert de La Chapelle
Allele separation facilitates interpretation of potential splicing alterations and genomic rearrangements.
Cancer research 2002;62(16):4579-82.
2002: Timothy Chan; Zhenghe Wang; Long H Dang; Bert Vogelstein; Kenneth W Kinzler
Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):8265-70.
2002: Saurabh Saha; Andrew B Sparks; Carlo Rago; Viatcheslav Akmaev; Clarence J Wang; Bert Vogelstein; Kenneth W Kinzler; Victor E Velculescu
Using the transcriptome to annotate the genome.
Nature biotechnology 2002;20(5):508-12.
2002: Ina Rhee; Kurtis E Bachman; Ben Ho Park; Kam-Wing Jair; Ray-Whay Chiu Yen; Kornel E Schuebel; Hengmi Cui; Andrew P Feinberg; Christoph Lengauer; Kenneth W Kinzler; Stephen B Baylin; Bert Vogelstein
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells.
Nature 2002;416(6880):552-6.
2002: Leigh Zawel; Jian Yu; Christopher J Torrance; Sanford Markowitz; Kenneth W Kinzler; Bert Vogelstein; Shibin Zhou
DEC1 is a downstream target of TGF-beta with sequence-specific transcriptional repressor activities.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2848-53.
2002: Tian-Li Wang; Carlo Rago; Natalie Silliman; Janine Ptak; Sanford Markowitz; James Willson; Giovanni Parmigiani; Kenneth W Kinzler; Bert Vogelstein; Victor E Velculescu
Prevalence of somatic alterations in the colorectal cancer cell genome.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):3076-80.
2002: Fred Bunz; Christine Fauth; Michael R Speicher; Annie Dutriaux; John M Sedivy; Kenneth W Kinzler; Bert Vogelstein; Christoph Lengauer
Targeted inactivation of p53 in human cells does not result in aneuploidy.
Cancer research 2002;62(4):1129-33.
2002: Giovanni Traverso; Anthony P Shuber; Louise Olsson; Bernard Levin; Constance Johnson; Stanley R Hamilton; Kevin Boynton; Kenneth W Kinzler; Bert Vogelstein
Detection of proximal colorectal cancers through analysis of faecal DNA.
Lancet 2002;359(9304):403-4.
2002: Giovanni Traverso; Anthony P Shuber; Bernard Levin; Constance Johnson; Louise Olsson; David J Schoetz; Stanley R Hamilton; Kevin Boynton; Kenneth W Kinzler; Bert Vogelstein
Detection of APC mutations in fecal DNA from patients with colorectal tumors.
The New England journal of medicine 2002;346(5):311-20.
2002: Wei Zhou; Steven Goodman; Gennaro Galizia; Eva Lieto; Franca Ferraraccio; Carlo Pignatelli; Colin A Purdie; Juan Piris; Robert Morris; David J Harrison; Philip B Paty; Al Culliford; Katharine E Romans; Elizabeth Montgomery; Michael A Choti; Kenneth W Kinzler; Bert Vogelstein
Counting alleles to predict recurrence of early-stage colorectal cancers.
Lancet 2002;359(9302):219-25.
2002: Hai Yan; Zuzana Dobbie; Stephen B Gruber; Sanford Markowitz; Katharine E Romans; Francis M Giardiello; Kenneth W Kinzler; Bert Vogelstein
Small changes in expression affect predisposition to tumorigenesis.
Nature genetics 2002;30(1):25-6.
2001: Long H Dang; Chetan Bettegowda; David L Huso; Kenneth W Kinzler; Bert Vogelstein
Combination bacteriolytic therapy for the treatment of experimental tumors.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):15155-60.
2001: Saurabh Saha; Alberto Bardelli; Phillip Buckhaults; Victor E Velculescu; Carlo Rago; Brad St Croix; Katharine E Romans; Michael A Choti; Christoph Lengauer; Kenneth W Kinzler; Bert Vogelstein
A phosphatase associated with metastasis of colorectal cancer.
Science (New York, N.Y.) 2001;294(5545):1343-6.
2001: T Liu; H Yan; Shannon Kuismanen; Antonio Percesepe; Marie-Luise Bisgaard; Monica Pedroni; Piero Benatti; Kenneth W Kinzler; Bert Vogelstein; Maurizio Ponz de Leon; Päivi Peltomäki; Annika Lindblom
The role of hPMS1 and hPMS2 in predisposing to colorectal cancer.
Cancer research 2001;61(21):7798-802.
2001: PAUL HWANG; Fred Bunz; J Yu; Carlo Rago; Timothy Chan; M P Murphy; G F Kelso; R A Smith; Kenneth W Kinzler; Bert Vogelstein
Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells.
Nature medicine 2001;7(10):1111-7.
2001: Phillip Buckhaults; Carlo Rago; Brad St Croix; Katharine E Romans; Saurabh Saha; Lin Zhang; Bert Vogelstein; Kenneth W Kinzler
Secreted and cell surface genes expressed in benign and malignant colorectal tumors.
Cancer research 2001;61(19):6996-7001.
2001: C J Torrance; V Agrawal; Bert Vogelstein; Kenneth W Kinzler
Use of isogenic human cancer cells for high-throughput screening and drug discovery.
Nature biotechnology 2001;19(10):940-5.
2001: Eleanor B Carson-Walter; DAVID WATKINS; Akash Nanda; Bert Vogelstein; Kenneth W Kinzler; Brad St Croix
Cell surface tumor endothelial markers are conserved in mice and humans.
Cancer research 2001;61(18):6649-55.
2001: Bert Vogelstein; Kenneth W Kinzler
Achilles' heel of cancer?
Nature 2001;412(6850):865-6.
2001: Seung Myung Dong; Giovanni Traverso; C Johnson; L Geng; Reyna Favis; Kevin Boynton; K Hibi; Steven Goodman; M D'Allessio; Philip B Paty; Stanley R Hamilton; David Sidransky; Francis Barany; B Levin; Anthony P Shuber; Kenneth W Kinzler; Bert Vogelstein; Jin Jen
Detecting colorectal cancer in stool with the use of multiple genetic targets.
Journal of the National Cancer Institute 2001;93(11):858-65.
2001: Prasad V Jallepalli; I C Waizenegger; Fred Bunz; S Langer; Michael R Speicher; J M Peters; Kenneth W Kinzler; Bert Vogelstein; Christoph Lengauer
Securin is required for chromosomal stability in human cells.
Cell 2001;105(4):445-57.
2001: A Bardelli; Daniel P Cahill; Gaby Lederer; Michael R Speicher; Kenneth W Kinzler; Bert Vogelstein; Christoph Lengauer
Carcinogen-specific induction of genetic instability.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5770-5.
2001: Lin Zhang; J Yu; James Willson; Sanford D Markowitz; Kenneth W Kinzler; Bert Vogelstein
Short mononucleotide repeat sequence variability in mismatch repair-deficient cancers.
Cancer research 2001;61(9):3801-5.
2001: J Yu; Lin Zhang; PAUL HWANG; Kenneth W Kinzler; Bert Vogelstein
PUMA induces the rapid apoptosis of colorectal cancer cells.
Molecular cell 2001;7(3):673-82.
2001: A B Sparks; Scott N Peterson; C Bell; B J Loftus; L Hocking; D P Cahill; Frank J Frassica; Elizabeth A Streeten; Michael A. Levine; Claire M Fraser-Liggett; Mark D Adams; Samuel Broder; J Craig Venter; Kenneth W Kinzler; Bert Vogelstein; S H Ralston
Mutation screening of the TNFRSF11A gene encoding receptor activator of NF kappa B (RANK) in familial and sporadic Paget's disease of bone and osteosarcoma.
Calcified tissue international 2001;68(3):151-5.
2001: S Thiagalingam; SJ Laken; James Willson; Sanford D Markowitz; Kenneth W Kinzler; Bert Vogelstein; Christoph Lengauer
Mechanisms underlying losses of heterozygosity in human colorectal cancers.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2698-702.
2001: Ie-Ming Shih; Tian-Li Wang; G Traverso; Katharine E Romans; Stanley R Hamilton; S Ben-Sasson; Kenneth W Kinzler; Bert Vogelstein
Top-down morphogenesis of colorectal tumors.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2640-5.
2001: Ben Ho Park; Bert Vogelstein; Kenneth W Kinzler
Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2598-603.
2001: Ie-Ming Shih; Wei Zhou; Steven Goodman; Christoph Lengauer; Kenneth W Kinzler; Bert Vogelstein
Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis.
Cancer research 2001;61(3):818-22.
2001: Stephen P Fink; Sandra Swinler; James Lutterbaugh; J Massagué; S Thiagalingam; Kenneth W Kinzler; Bert Vogelstein; James Willson; Sanford Markowitz
Transforming growth factor-beta-induced growth inhibition in a Smad4 mutant colon adenoma cell line.
Cancer research 2001;61(1):256-60.
2001: Wei Zhou; Gennaro Galizia; Eva Lieto; Steven Goodman; Katharine E Romans; Kenneth W Kinzler; Bert Vogelstein; Michael A Choti; Elizabeth Montgomery
Counting alleles reveals a connection between chromosome 18q loss and vascular invasion.
Nature biotechnology 2001;19(1):78-81.
2000: Lin Zhang; J Yu; Ben Ho Park; Kenneth W Kinzler; Bert Vogelstein
Role of BAX in the apoptotic response to anticancer agents.
Science (New York, N.Y.) 2000;290(5493):989-92.
2000: Victor E Velculescu; Bert Vogelstein; Kenneth W Kinzler
Analysing uncharted transcriptomes with SAGE.
Trends in genetics : TIG 2000;16(10):423-5.
2000: H Yan; Kenneth W Kinzler; Bert Vogelstein
Tech.sight. Genetic testing--present and future.
Science (New York, N.Y.) 2000;289(5486):1890-2.
2000: C J Torrance; P E Jackson; Elizabeth Montgomery; Kenneth W Kinzler; Bert Vogelstein; Allan Wissner; M Nunes; P Frost; Carolyn Discafani
Combinatorial chemoprevention of intestinal neoplasia.
Nature medicine 2000;6(9):1024-8.
2000: Brad St Croix; Carlo Rago; Victor E Velculescu; Giovanni Traverso; Katharine E Romans; Elizabeth Montgomery; A Lal; Gregory J Riggins; Christoph Lengauer; Bert Vogelstein; Kenneth W Kinzler
Genes expressed in human tumor endothelium.
Science (New York, N.Y.) 2000;289(5482):1197-202.
2000: PM Flatt; Kornelia Polyak; Luo Jia Tang; CD Scatena; Matthew D Westfall; L A Rubinstein; J Yu; Kenneth W Kinzler; Bert Vogelstein; David E Hill; Jennifer A Pietenpol
p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest.
Cancer letters 2000;156(1):63-72.
2000: Timothy Chan; PAUL HWANG; H Hermeking; Kenneth W Kinzler; Bert Vogelstein
Cooperative effects of genes controlling the G(2)/M checkpoint.
Genes & development 2000;14(13):1584-8.
2000: Ie-Ming Shih; C Torrance; Lori J Sokoll; Daniel W Chan; Kenneth W Kinzler; Bert Vogelstein
Assessing tumors in living animals through measurement of urinary beta-human chorionic gonadotropin.
Nature medicine 2000;6(6):711-4.
2000: Ina Rhee; Kam-Wing Jair; Ray-Whay Chiu Yen; Christoph Lengauer; James G Herman; Kenneth W Kinzler; Bert Vogelstein; Stephen B Baylin; Kornel E Schuebel
CpG methylation is maintained in human cancer cells lacking DNMT1.
Nature 2000;404(6781):1003-7.
2000: Ie-Ming Shih; J Yu; Tong-Chuan He; Bert Vogelstein; Kenneth W Kinzler
The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression.
Cancer research 2000;60(6):1671-6.
2000: H Hermeking; Carlo Rago; M Schuhmacher; Q Li; J F Barrett; Alvaro J Obaya; Brenda C. O'Connell; Maria K Mateyak; W Tam; Franz Kohlhuber; Chi Dang; John M Sedivy; Dirk Eick; Bert Vogelstein; Kenneth W Kinzler
Identification of CDK4 as a target of c-MYC.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2229-34.
2000: H Yan; Nickolas Papadopoulos; Giancarlo Marra; Claudia Perrera; Josef Jiricny; C R Boland; H T Lynch; R B Chadwick; ALBERT DE LA CHAPELLE; K Berg; James R Eshleman; W Yuan; S Markowitz; SJ Laken; Christoph Lengauer; Kenneth W Kinzler; Bert Vogelstein
Conversion of diploidy to haploidy.
Nature 2000;403(6771):723-4.
1999: J Yu; Lin Zhang; PAUL HWANG; Carlo Rago; Kenneth W Kinzler; Bert Vogelstein
Identification and classification of p53-regulated genes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(25):14517-22.
1999: Daniel P Cahill; Kenneth W Kinzler; Bert Vogelstein; Christoph Lengauer
Genetic instability and darwinian selection in tumours.
Trends in cell biology 1999;9(12):M57-60.
1999: Victor E Velculescu; S L Madden; Lin Zhang; Alex E Lash; J Yu; Carlo Rago; A Lal; C J Wang; GA Beaudry; K M Ciriello; Brian P Cook; Michael R Dufault; AT Ferguson; Y Gao; Tong-Chuan He; H Hermeking; S K Hiraldo; PAUL HWANG; M A Lopez; H F Luderer; B Mathews; Joseph Petroziello; Kornelia Polyak; L Zawel; Kenneth W Kinzler
Analysis of human transcriptomes.
Nature genetics 1999;23(4):387-8.
1999: Anita Lal; Alex E Lash; Stephen F Altschul; Victor E Velculescu; L Zhang; Roger E McLendon; Marco A Marra; C Prange; Patrice J Morin; Kornelia Polyak; Nickolas Papadopoulos; Bert Vogelstein; Kenneth W Kinzler; Robert L Strausberg; Gregory J Riggins
A public database for gene expression in human cancers.
Cancer research 1999;59(21):5403-7.
1999: Tong-Chuan He; Timothy Chan; Bert Vogelstein; Kenneth W Kinzler
PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs.
Cell 1999;99(3):335-45.
1999: Timothy Chan; H Hermeking; Christoph Lengauer; Kenneth W Kinzler; Bert Vogelstein
14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage.
Nature 1999;401(6753):616-20.
1999: Shibin Zhou; Kenneth W Kinzler; Bert Vogelstein
Going mad with Smads.
The New England journal of medicine 1999;341(15):1144-6.
1999: Munira A Basrai; Victor E Velculescu; Kenneth W Kinzler; Philip Hieter
NORF5/HUG1 is a component of the MEC1-mediated checkpoint response to DNA damage and replication arrest in Saccharomyces cerevisiae.
Molecular and cellular biology 1999;19(10):7041-9.
1999: LT da Costa; Tong-Chuan He; J Yu; Andrew B Sparks; Patrice J Morin; Kornelia Polyak; SJ Laken; Bert Vogelstein; Kenneth W Kinzler
CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling.
Oncogene 1999;18(35):5010-4.
1999: Bert Vogelstein; Kenneth W Kinzler
Digital PCR.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(16):9236-41.
1999: Fred Bunz; PAUL HWANG; C Torrance; Todd Waldman; Y Zhang; Larry E Dillehay; J Williams; Christoph Lengauer; Kenneth W Kinzler; Bert Vogelstein
Disruption of p53 in human cancer cells alters the responses to therapeutic agents.
The Journal of clinical investigation 1999;104(3):263-9.
1999: Daniel P Cahill; L T da Costa; Eleanor B Carson-Walter; Kenneth W Kinzler; Bert Vogelstein; Christoph Lengauer
Characterization of MAD2B and other mitotic spindle checkpoint genes.
Genomics 1999;58(2):181-7.
1999: SJ Laken; Nickolas Papadopoulos; Gloria M Petersen; Stephen B Gruber; Stanley R Hamilton; Francis M Giardiello; JD Brensinger; Bert Vogelstein; Kenneth W Kinzler
Analysis of masked mutations in familial adenomatous polyposis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2322-6.
1999: William M Grady; Lois Myeroff; Sandra Swinler; Ashwani Rajput; S Thiagalingam; James Lutterbaugh; A Neumann; Michael G Brattain; J Chang; S J Kim; Kenneth W Kinzler; Bert Vogelstein; James Willson; Sanford Markowitz
Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers.
Cancer research 1999;59(2):320-4.
1999: Stephen B Gruber; Gloria M Petersen; Kenneth W Kinzler; Bert Vogelstein
Cancer, crash sites, and the new genetics of neoplasia.
Gastroenterology 1999;116(1):210-2.
1998: Christoph Lengauer; Kenneth W Kinzler; Bert Vogelstein
Genetic instabilities in human cancers.
Nature 1998;396(6712):643-9.
1998: S J Laken; Peta E Jackson; Kenneth W Kinzler; Bert Vogelstein; Paul T Strickland; John Groopman; Marlin Friesen
Genotyping by mass spectrometric analysis of short DNA fragments.
Nature biotechnology 1998;16(13):1352-6.
1998: Stephen B Gruber; MM Entius; Gloria M Petersen; SJ Laken; P A Longo; R Boyer; Al Levin; Urvi Mujumdar; Jeffrey M. Trent; Kenneth W Kinzler; Bert Vogelstein; Stanley R Hamilton; Mihael H Polymeropoulos; G Johan A Offerhaus; Francis M Giardiello
Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome.
Cancer research 1998;58(23):5267-70.
1998: Fred Bunz; Annie Dutriaux; Christoph Lengauer; Todd Waldman; Shibin Zhou; J P Brown; John M Sedivy; Kenneth W Kinzler; Bert Vogelstein
Requirement for p53 and p21 to sustain G2 arrest after DNA damage.
Science (New York, N.Y.) 1998;282(5393):1497-501.
1998: Kornelia Polyak; Y Li; H Zhu; Christoph Lengauer; James Willson; Sanford D Markowitz; Michael A Trush; Kenneth W Kinzler; Bert Vogelstein
Somatic mutations of the mitochondrial genome in human colorectal tumours.
Nature genetics 1998;20(3):291-3.
1998: Tong-Chuan He; Andrew B Sparks; Carlo Rago; H Hermeking; L Zawel; LT da Costa; Patrice J Morin; Bert Vogelstein; Kenneth W Kinzler
Identification of c-MYC as a target of the APC pathway.
Science (New York, N.Y.) 1998;281(5382):1509-12.
1998: Shibin Zhou; L Zawel; Christoph Lengauer; Kenneth W Kinzler; Bert Vogelstein
Characterization of human FAST-1, a TGF beta and activin signal transducer.
Molecular cell 1998;2(1):121-7.
1998: James G Herman; A Umar; Kornelia Polyak; Jeremy R Graff; NITA AHUJA; Jean-Pierre J Issa; Sanford Markowitz; James Willson; Stanley R Hamilton; Kenneth W Kinzler; Michael F Kane; Richard D Kolodner; Bert Vogelstein; T A Kunkel; Stephen B Baylin
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6870-5.
1998: Kenneth W Kinzler; Bert Vogelstein
Landscaping the cancer terrain.
Science (New York, N.Y.) 1998;280(5366):1036-7.
1998: Daniel P Cahill; Christoph Lengauer; J Yu; Gregory J Riggins; James Willson; Sanford D Markowitz; Kenneth W Kinzler; Bert Vogelstein
Mutations of mitotic checkpoint genes in human cancers.
Nature 1998;392(6673):300-3.
1998: Andrew B Sparks; Patrice J Morin; Bert Vogelstein; Kenneth W Kinzler
Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.
Cancer research 1998;58(6):1130-4.
1998: Tong-Chuan He; Shibin Zhou; LT da Costa; J Yu; Kenneth W Kinzler; Bert Vogelstein
A simplified system for generating recombinant adenoviruses.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(5):2509-14.
1998: Shibin Zhou; Phillip Buckhaults; L Zawel; Fred Bunz; Gregory J Riggins; J L Dai; Scott E Kern; Kenneth W Kinzler; Bert Vogelstein
Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(5):2412-6.
1998: L Zawel; J L Dai; Phillip Buckhaults; Shibin Zhou; Kenneth W Kinzler; Bert Vogelstein; Scott E Kern
Human Smad3 and Smad4 are sequence-specific transcription activators.
Molecular cell 1998;1(4):611-7.
1998: N C Nicolaides; Susan J Littman; Paul Modrich; Kenneth W Kinzler; Bert Vogelstein
A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype.
Molecular and cellular biology 1998;18(3):1635-41.
1998: Wei Zhou; Lori J Sokoll; Debra J Bruzek; Lin Zhang; Victor E Velculescu; S B Goldin; Ralph Hruban; Scott E Kern; Stanley R Hamilton; Daniel W Chan; Bert Vogelstein; Kenneth W Kinzler
Identifying markers for pancreatic cancer by gene expression analysis.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1998;7(2):109-12.
1998: Timothy Chan; Patrice J Morin; Bert Vogelstein; Kenneth W Kinzler
Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(2):681-6.
1997: H Hermeking; Christoph Lengauer; Kornelia Polyak; Tong-Chuan He; Lin Zhang; S Thiagalingam; Kenneth W Kinzler; Bert Vogelstein
14-3-3 sigma is a p53-regulated inhibitor of G2/M progression.
Molecular cell 1997;1(1):3-11.
1997: Kornelia Polyak; Y Xia; Jay L Zweier; Kenneth W Kinzler; Bert Vogelstein
A model for p53-induced apoptosis.
Nature 1997;389(6648):300-5.
1997: Todd Waldman; Y Zhang; Larry E Dillehay; J Yu; Kenneth W Kinzler; Bert Vogelstein; J Williams
Cell-cycle arrest versus cell death in cancer therapy.
Nature medicine 1997;3(9):1034-6.
1997: SJ Laken; Gloria M Petersen; Stephen B Gruber; Carole Oddoux; Harry Ostrer; Francis M Giardiello; Stanley R Hamilton; H Hampel; Arnold J Markowitz; David S Klimstra; Suresh C Jhanwar; Sidney J Winawer; Kenneth Offit; MC Luce; Kenneth W Kinzler; Bert Vogelstein
Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC.
Nature genetics 1997;17(1):79-83.
1997: Gregory J Riggins; Kenneth W Kinzler; Bert Vogelstein; S Thiagalingam
Frequency of Smad gene mutations in human cancers.
Cancer research 1997;57(13):2578-80.
1997: Lin Zhang; Wei Zhou; Victor E Velculescu; Scott E Kern; Ralph Hruban; S R Hamilton; Bert Vogelstein; Kenneth W Kinzler
Gene expression profiles in normal and cancer cells.
Science (New York, N.Y.) 1997;276(5316):1268-72.
1997: Kenneth W Kinzler; Bert Vogelstein
Cancer-susceptibility genes. Gatekeepers and caretakers.
Nature 1997;386(6627):761, 763.
1997: Christoph Lengauer; Kenneth W Kinzler; Bert Vogelstein
Genetic instability in colorectal cancers.
Nature 1997;386(6625):623-7.
1997: Kornelia Polyak; T T Wu; Stanley R Hamilton; Kenneth W Kinzler; Bert Vogelstein
Less death in the dying.
Cell death and differentiation 1997;4(3):242-6.
1997: Francis M Giardiello; Gloria M Petersen; Steven Piantadosi; Stephen B Gruber; Elias Traboulsi; G Johan A Offerhaus; K Muro; Anne J Krush; Susan V Booker; MC Luce; SJ Laken; Kenneth W Kinzler; Bert Vogelstein; Stanley R Hamilton
APC gene mutations and extraintestinal phenotype of familial adenomatous polyposis.
Gut 1997;40(4):521-5.
1997: Patrice J Morin; Andrew B Sparks; V Korinek; Nick Barker; Hans Clevers; Bert Vogelstein; Kenneth W Kinzler
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC.
Science (New York, N.Y.) 1997;275(5307):1787-90.
1997: V Korinek; Nick Barker; Patrice J Morin; D van Wichen; Roel A de Weger; Kenneth W Kinzler; Bert Vogelstein; Hans Clevers
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma.
Science (New York, N.Y.) 1997;275(5307):1784-7.
1997: Christoph Lengauer; Kenneth W Kinzler; Bert Vogelstein
DNA methylation and genetic instability in colorectal cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2545-50.
1997: Victor E Velculescu; Lin Zhang; Wei Zhou; J Vogelstein; Munira A Basrai; D E Bassett; Philip Hieter; Bert Vogelstein; Kenneth W Kinzler
Characterization of the yeast transcriptome.
Cell 1997;88(2):243-51.
1997: Malcolm G Dunlop; Susan M Farrington; Andrew D Carothers; Andrew H Wyllie; Linda Sharp; J Burn; B Liu; Kenneth W Kinzler; Bert Vogelstein
Cancer risk associated with germline DNA mismatch repair gene mutations.
Human molecular genetics 1997;6(1):105-10.
1996: Kenneth W Kinzler; Bert Vogelstein
Lessons from hereditary colorectal cancer.
Cell 1996;87(2):159-70.
1996: Kenneth W Kinzler; Bert Vogelstein
Breast cancer. What's mice got to do with it?
Nature 1996;382(6593):672.
1996: J Huang; Nickolas Papadopoulos; A J McKinley; Susan M Farrington; Lucy J Curtis; Andrew H Wyllie; S Zheng; James Willson; S D Markowitz; Patrice J Morin; Kenneth W Kinzler; Bert Vogelstein; Malcolm G Dunlop
APC mutations in colorectal tumors with mismatch repair deficiency.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):9049-54.
1996: J A Pietenpol; Christoph Lengauer; J Jordan; Kenneth W Kinzler; Bert Vogelstein
Mammalian cells resistant to tumor suppressor genes.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8390-4.
1996: Y Beazer-Barclay; D B Levy; AR Moser; William F Dove; Stanley R Hamilton; Bert Vogelstein; Kenneth W Kinzler
Sulindac suppresses tumorigenesis in the Min mouse.
Carcinogenesis 1996;17(8):1757-60.
1996: Kornelia Polyak; Todd Waldman; Tong-Chuan He; Kenneth W Kinzler; Bert Vogelstein
Genetic determinants of p53-induced apoptosis and growth arrest.
Genes & development 1996;10(15):1945-52.
1996: Kornelia Polyak; Stanley R Hamilton; Bert Vogelstein; Kenneth W Kinzler
Early alteration of cell-cycle-regulated gene expression in colorectal neoplasia.
The American journal of pathology 1996;149(2):381-7.
1996: Patrice J Morin; Bert Vogelstein; Kenneth W Kinzler
Apoptosis and APC in colorectal tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7950-4.
1996: S Thiagalingam; N A Lisitsyn; M Hamaguchi; Michael Wigler; James Willson; Sanford D Markowitz; F S Leach; Kenneth W Kinzler; Bert Vogelstein
Evaluation of the FHIT gene in colorectal cancers.
Cancer research 1996;56(13):2936-9.
1996: Gregory J Riggins; S Thiagalingam; E Rozenblum; C L Weinstein; Scott E Kern; Stanley R Hamilton; James Willson; Sanford D Markowitz; Kenneth W Kinzler; Bert Vogelstein
Mad-related genes in the human.
Nature genetics 1996;13(3):347-9.
1996: S Thiagalingam; Christoph Lengauer; F S Leach; Mieke Schutte; Stephan Hahn; J Overhauser; James Willson; Sanford Markowitz; Stanley R Hamilton; Scott E Kern; Kenneth W Kinzler; Bert Vogelstein
Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers.
Nature genetics 1996;13(3):343-6.
1996: Todd Waldman; Christoph Lengauer; Kenneth W Kinzler; Bert Vogelstein
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21.
Nature 1996;381(6584):713-6.
1996: R V Bhat; K J Axt; J S Fosnaugh; K J Smith; K A Johnson; David E Hill; Kenneth W Kinzler; Jay M Baraban
Expression of the APC tumor suppressor protein in oligodendroglia.
Glia 1996;17(2):169-74.
1996: LT da Costa; Jin Jen; Tong-Chuan He; Timothy Chan; Kenneth W Kinzler; Bert Vogelstein
Converting cancer genes into killer genes.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):4192-6.
1996: Ann R Kennedy; Y Beazer-Barclay; Kenneth W Kinzler; P M Newberne
Suppression of carcinogenesis in the intestines of min mice by the soybean-derived Bowman-Birk inhibitor.
Cancer research 1996;56(4):679-82.
1996: N C Nicolaides; Fabio Palombo; Kenneth W Kinzler; Bert Vogelstein; Josef Jiricny
Molecular cloning of the N-terminus of GTBP.
Genomics 1996;31(3):395-7.
1996: B Liu; R Parsons; Nickolas Papadopoulos; N C Nicolaides; H T Lynch; P Watson; J R Jass; M Dunlop; Andrew H Wyllie; Päivi Peltomäki; ALBERT DE LA CHAPELLE; Stanley R Hamilton; Bert Vogelstein; Kenneth W Kinzler
Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients.
Nature medicine 1996;2(2):169-74.
1996: F S Leach; Kornelia Polyak; M Burrell; K A Johnson; D Hill; M G Dunlop; Andrew H Wyllie; P Peltomaki; ALBERT DE LA CHAPELLE; Stanley R Hamilton; Kenneth W Kinzler; Bert Vogelstein
Expression of the human mismatch repair gene hMSH2 in normal and neoplastic tissues.
Cancer research 1996;56(2):235-40.
1996: Kenneth W Kinzler; Bert Vogelstein
Life (and death) in a malignant tumour.
Nature 1996;379(6560):19-20.
1995: R Parsons; Lois Myeroff; B Liu; James Willson; Sanford D Markowitz; Kenneth W Kinzler; Bert Vogelstein
Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer.
Cancer research 1995;55(23):5548-50.
1995: Lois Myeroff; R Parsons; S J Kim; L Hedrick; Kathleen R Cho; K Orth; M Mathis; Kenneth W Kinzler; James Lutterbaugh; K Park
A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability.
Cancer research 1995;55(23):5545-7.
1995: N C Nicolaides; KC Carter; BK Shell; Nickolas Papadopoulos; Bert Vogelstein; Kenneth W Kinzler
Genomic organization of the human PMS2 gene family.
Genomics 1995;30(2):195-206.
1995: Todd Waldman; Kenneth W Kinzler; Bert Vogelstein
p21 is necessary for the p53-mediated G1 arrest in human cancer cells.
Cancer research 1995;55(22):5187-90.
1995: Gregory J Riggins; Sanford Markowitz; J K Wilson; Bert Vogelstein; Kenneth W Kinzler
Absence of secretory phospholipase A2 gene alterations in human colorectal cancer.
Cancer research 1995;55(22):5184-6.
1995: Minna Nyström-Lahti; Paula Kristo; N C Nicolaides; S Y Chang; Lauri A Aaltonen; Anu-Liisa Moisio; Heikki J Järvinen; Jukka-Pekka Mecklin; Kenneth W Kinzler; Bert Vogelstein
Founding mutations and Alu-mediated recombination in hereditary colon cancer.
Nature medicine 1995;1(11):1203-6.
1995: Victor E Velculescu; Lin Zhang; Bert Vogelstein; Kenneth W Kinzler
Serial analysis of gene expression.
Science (New York, N.Y.) 1995;270(5235):484-7.
1995: N C Nicolaides; Kenneth W Kinzler; Bert Vogelstein
Analysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene.
Genomics 1995;29(2):329-34.
1995: Nickolas Papadopoulos; F S Leach; Kenneth W Kinzler; Bert Vogelstein
Monoallelic mutation analysis (MAMA) for identifying germline mutations.
Nature genetics 1995;11(1):99-102.
1995: L K Su; M Burrell; David E Hill; J Gyuris; R Brent; R Wiltshire; Jeffrey M. Trent; Bert Vogelstein; Kenneth W Kinzler
APC binds to the novel protein EB1.
Cancer research 1995;55(14):2972-7.
1995: Nickolas Papadopoulos; N C Nicolaides; B Liu; R Parsons; Christoph Lengauer; Fabio Palombo; A D'Arrigo; Sanford Markowitz; James Willson; Kenneth W Kinzler
Mutations of GTBP in genetically unstable cells.
Science (New York, N.Y.) 1995;268(5219):1915-7.
1995: S Thiagalingam; Kenneth W Kinzler; Bert Vogelstein
PAK1, a gene that can regulate p53 activity in yeast.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):6062-6.
1995: Sanford Markowitz; Jianyong Wang; Lois Myeroff; R Parsons; Luzhe Sun; James Lutterbaugh; R S Fan; Elizabeth Zborowska; Kenneth W Kinzler; Bert Vogelstein
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability.
Science (New York, N.Y.) 1995;268(5215):1336-8.
1995: R Parsons; G M Li; M Longley; Paul Modrich; B Liu; T Berk; S R Hamilton; Kenneth W Kinzler; Bert Vogelstein
Mismatch repair deficiency in phenotypically normal human cells.
Science (New York, N.Y.) 1995;268(5211):738-40.
1995: K F Macleod; N Sherry; G Hannon; D Beach; T Tokino; Kenneth W Kinzler; Bert Vogelstein; Tyler Jacks
p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.
Genes & development 1995;9(8):935-44.
1995: B Liu; Susan M Farrington; Gloria M Petersen; Stanley R Hamilton; R Parsons; Nickolas Papadopoulos; T Fujiwara; Jin Jen; Kenneth W Kinzler; A H Wyllie; Bert Vogelstein; M G Dunlop
Genetic instability occurs in the majority of young patients with colorectal cancer.
Nature medicine 1995;1(4):348-52.
1995: Bert Vogelstein; Kenneth W Kinzler
Through the glass lightly.
Science (New York, N.Y.) 1995;267(5204):1613.
1995: J A Pietenpol; S K Bohlander; Y Sato; Nickolas Papadopoulos; B Liu; C Friedman; B J Trask; J M Roberts; Kenneth W Kinzler; J D Rowley
Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias.
Cancer research 1995;55(6):1206-10.
1995: M S Redston; Nickolas Papadopoulos; Carlos Caldas; Kenneth W Kinzler; Scott E Kern
Common occurrence of APC and K-ras gene mutations in the spectrum of colitis-associated neoplasias.
Gastroenterology 1995;108(2):383-92.
1995: Jeffrey M. Trent; R Wiltshire; L K Su; N C Nicolaides; Bert Vogelstein; Kenneth W Kinzler
The gene for the APC-binding protein beta-catenin (CTNNB1) maps to chromosome 3p22, a region frequently altered in human malignancies.
Cytogenetics and cell genetics 1995;71(4):343-4.
1995: L T da Costa; B Liu; Wafik S El-Deiry; S R Hamilton; Kenneth W Kinzler; Bert Vogelstein; S Markowitz; James Willson; ALBERT DE LA CHAPELLE; K M Downey
Polymerase delta variants in RER colorectal tumours.
Nature genetics 1995;9(1):10-1.
1994: Jin Jen; J W Harper; S H Bigner; D D Bigner; Nickolas Papadopoulos; Sanford Markowitz; James Willson; Kenneth W Kinzler; Bert Vogelstein
Deletion of p16 and p15 genes in brain tumors.
Cancer research 1994;54(24):6353-8.
1994: S M Powell; Nickolas Papadopoulos; Kenneth W Kinzler; Kara N Smolinski; Meltzer Stephen J.
APC gene mutations in the mutation cluster region are rare in esophageal cancers.
Gastroenterology 1994;107(6):1759-63.
1994: D B Levy; K J Smith; Y Beazer-Barclay; Stanley R Hamilton; Bert Vogelstein; Kenneth W Kinzler
Inactivation of both APC alleles in human and mouse tumors.
Cancer research 1994;54(22):5953-8.
1994: Jin Jen; Steven M Powell; Nickolas Papadopoulos; K J Smith; Stanley R Hamilton; Bert Vogelstein; Kenneth W Kinzler
Molecular determinants of dysplasia in colorectal lesions.
Cancer research 1994;54(21):5523-6.
1994: F S Leach; N C Nicolaides; Pertti Sistonen; J W Yu; F T Kao; ALBERT DE LA CHAPELLE; Kenneth W Kinzler; Bert Vogelstein
Three dinucleotide repeat polymorphisms proximal to the D2S123 locus.
Human molecular genetics 1994;3(11):2082.
1994: Bert Vogelstein; Kenneth W Kinzler
Has the breast cancer gene been found?
Cell 1994;79(1):1-3.
1994: T Tokino; S Thiagalingam; Wafik S El-Deiry; Todd Waldman; Kenneth W Kinzler; Bert Vogelstein
p53 tagged sites from human genomic DNA.
Human molecular genetics 1994;3(9):1537-42.
1994: Scott E Kern; M Redston; A B Seymour; Carlos Caldas; Steven M Powell; S Kornacki; Kenneth W Kinzler
Molecular genetic profiles of colitis-associated neoplasms.
Gastroenterology 1994;107(2):420-8.
1994: Jin Jen; H Kim; Steven Piantadosi; Z F Liu; Roy Levitt; Pertti Sistonen; Kenneth W Kinzler; Bert Vogelstein; Stanley R Hamilton
Allelic loss of chromosome 18q and prognosis in colorectal cancer.
The New England journal of medicine 1994;331(4):213-21.
1994: Bert Vogelstein; Kenneth W Kinzler
Tumour-suppressor genes. X-rays strike p53 again.
Nature 1994;370(6486):174-5.
1994: J A Pietenpol; Nickolas Papadopoulos; Sanford Markowitz; James Willson; Kenneth W Kinzler; Bert Vogelstein
Paradoxical inhibition of solid tumor cell growth by bcl2.
Cancer research 1994;54(14):3714-7.
1994: K J Smith; D B Levy; P Maupin; T D Pollard; Bert Vogelstein; Kenneth W Kinzler
Wild-type but not mutant APC associates with the microtubule cytoskeleton.
Cancer research 1994;54(14):3672-5.
1994: Kenneth W Kinzler; Bert Vogelstein
Cancer therapy meets p53.
The New England journal of medicine 1994;331(1):49-50.
1994: A B Seymour; Ralph Hruban; M Redston; Carlos Caldas; Steven M Powell; Kenneth W Kinzler; Charles J Yeo; Scott E Kern
Allelotype of pancreatic adenocarcinoma.
Cancer research 1994;54(10):2761-4.
1994: L Hedrick; Kathleen R Cho; Eric R Fearon; Tzyy-choou Wu; Kenneth W Kinzler; Bert Vogelstein
The DCC gene product in cellular differentiation and colorectal tumorigenesis.
Genes & development 1994;8(10):1174-83.
1994: J A Pietenpol; T Tokino; S Thiagalingam; Wafik S El-Deiry; Kenneth W Kinzler; Bert Vogelstein
Sequence-specific transcriptional activation is essential for growth suppression by p53.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(6):1998-2002.
1994: Bert Vogelstein; Kenneth W Kinzler
Colorectal cancer and the intersection between basic and clinical research.
Cold Spring Harbor symposia on quantitative biology 1994;59():517-21.
1993: Steven M Powell; Gloria M Petersen; Anne J Krush; Susan V Booker; Jin Jen; Francis M Giardiello; Stanley R Hamilton; Bert Vogelstein; Kenneth W Kinzler
Molecular diagnosis of familial adenomatous polyposis.
The New England journal of medicine 1993;329(27):1982-7.
1993: R Parsons; G M Li; M J Longley; W H Fang; Nickolas Papadopoulos; Jin Jen; ALBERT DE LA CHAPELLE; Kenneth W Kinzler; Bert Vogelstein; Paul Modrich
Hypermutability and mismatch repair deficiency in RER+ tumor cells.
Cell 1993;75(6):1227-36.
1993: L K Su; Bert Vogelstein; Kenneth W Kinzler
Association of the APC tumor suppressor protein with catenins.
Science (New York, N.Y.) 1993;262(5140):1734-7.
1993: Wafik S El-Deiry; T Tokino; Victor E Velculescu; D B Levy; R Parsons; Jeffrey M. Trent; D Lin; W E Mercer; Kenneth W Kinzler; Bert Vogelstein
WAF1, a potential mediator of p53 tumor suppression.
Cell 1993;75(4):817-25.
1993: J D Oliner; Kenneth W Kinzler; Bert Vogelstein
In vivo cloning of PCR products in E. coli.
Nucleic acids research 1993;21(22):5192-7.
1993: L K Su; K A Johnson; K J Smith; David E Hill; Bert Vogelstein; Kenneth W Kinzler
Association between wild type and mutant APC gene products.
Cancer research 1993;53(12):2728-31.
1993: Kenneth W Kinzler; Bert Vogelstein
Cancer. A gene for neurofibromatosis 2.
Nature 1993;363(6429):495-6.
1993: F S Leach; T Tokino; P Meltzer; M Burrell; J D Oliner; S Smith; David E Hill; David Sidransky; Kenneth W Kinzler; Bert Vogelstein
p53 Mutation and MDM2 amplification in human soft tissue sarcomas.
Cancer research 1993;53(10 Suppl):2231-4.
1993: F S Leach; S J Elledge; C J Sherr; James Willson; Sanford Markowitz; Kenneth W Kinzler; Bert Vogelstein
Amplification of cyclin genes in colorectal carcinomas.
Cancer research 1993;53(9):1986-9.
1993: Gloria M Petersen; Clair A Francomano; Kenneth W Kinzler; Y Nakamura
Presymptomatic direct detection of adenomatous polyposis coli (APC) gene mutations in familial adenomatous polyposis.
Human genetics 1993;91(4):307-11.
1993: J D Oliner; J A Pietenpol; S Thiagalingam; J Gyuris; Kenneth W Kinzler; Bert Vogelstein
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53.
Nature 1993;362(6423):857-60.
1993: Bert Vogelstein; Kenneth W Kinzler
The multistep nature of cancer.
Trends in genetics : TIG 1993;9(4):138-41.
1993: Cindy L Luongo; Karen A Gould; L K Su; Kenneth W Kinzler; Bert Vogelstein; W Dietrich; Eric S Lander; AR Moser
Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse.
Genomics 1993;15(1):3-8.
1992: Kenneth W Kinzler; Bert Vogelstein
The colorectal cancer gene hunt: current findings.
Hospital practice (Office ed.) 1992;27(11):51-8.
1992: Y Nakamura; I Nishisho; Kenneth W Kinzler; Bert Vogelstein; Y Miyoshi; Y Miki; H Ando; A Horii
Mutations of the APC (adenomatous polyposis coli) gene in FAP (familial polyposis coli) patients and in sporadic colorectal tumors.
The Tohoku journal of experimental medicine 1992;168(2):141-7.
1992: S M Powell; N Zilz; Y Beazer-Barclay; T M Bryan; S R Hamilton; S N Thibodeau; Bert Vogelstein; Kenneth W Kinzler
APC mutations occur early during colorectal tumorigenesis.
Nature 1992;359(6392):235-7.
1992: Bert Vogelstein; Kenneth W Kinzler
p53 function and dysfunction.
Cell 1992;70(4):523-6.
1992: J W Simons; J D Oliner; Kathleen R Cho; Kenneth W Kinzler; Bert Vogelstein
SAM 1.1 and JOSH 4.4: two RFLPs within the human DCC gene.
Human molecular genetics 1992;1(5):352.
1992: Monica J Justice; DJ Gilbert; Kenneth W Kinzler; Bert Vogelstein; Arthur M Buchberg; J D Ceci; Y Matsuda; Verne M Chapman; Christos Patriotis; A Makris
A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18.
Genomics 1992;13(4):1281-8.
1992: J D Oliner; Kenneth W Kinzler; Paul S Meltzer; D L George; Bert Vogelstein
Amplification of a gene encoding a p53-associated protein in human sarcomas.
Nature 1992;358(6381):80-3.
1992: Scott E Kern; J A Pietenpol; S Thiagalingam; A Seymour; Kenneth W Kinzler; Bert Vogelstein
Oncogenic forms of p53 inhibit p53-regulated gene expression.
Science (New York, N.Y.) 1992;256(5058):827-30.
1992: L K Su; Kenneth W Kinzler; Bert Vogelstein; A C Preisinger; AR Moser; Cindy L Luongo; Karen A Gould; William F Dove
Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene.
Science (New York, N.Y.) 1992;256(5057):668-70.
1992: David Sidransky; T Tokino; Stanley R Hamilton; Kenneth W Kinzler; B Levin; P Frost; Bert Vogelstein
Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors.
Science (New York, N.Y.) 1992;256(5053):102-5.
1992: Wafik S El-Deiry; Scott E Kern; J A Pietenpol; Kenneth W Kinzler; Bert Vogelstein
Definition of a consensus binding site for p53.
Nature genetics 1992;1(1):45-9.
1992: M C Goyette; Kathleen R Cho; C L Fasching; D B Levy; Kenneth W Kinzler; C Paraskeva; Bert Vogelstein; Eric J Stanbridge
Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer.
Molecular and cellular biology 1992;12(3):1387-95.
1992: Y Miki; I Nishisho; A Horii; Y Miyoshi; J Utsunomiya; Kenneth W Kinzler; Bert Vogelstein; Y Nakamura
Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer.
Cancer research 1992;52(3):643-5.
1992: Bert Vogelstein; Kenneth W Kinzler
Carcinogens leave fingerprints.
Nature 1992;355(6357):209-10.
1992: Y Miyoshi; I Nishisho; Y Miki; T Mori; Kenneth W Kinzler; Bert Vogelstein; Y Nakamura
Insertion/deletion polymorphism and other restriction fragment length polymorphisms in the MCC gene.
Japanese journal of cancer research : Gann 1992;83(1):10-4.
1991: Kenneth W Kinzler; M C Nilbert; L K Su; Bert Vogelstein; T M Bryan; D B Levy; K J Smith; A C Preisinger; P Hedge; D McKechnie
Identification of FAP locus genes from chromosome 5q21.
Science (New York, N.Y.) 1991;253(5020):661-5.
1991: Scott E Kern; Kenneth W Kinzler; A Bruskin; D Jarosz; P Friedman; C Prives; Bert Vogelstein
Identification of p53 as a sequence-specific DNA-binding protein.
Science (New York, N.Y.) 1991;252(5013):1708-11.
1991: Kenneth W Kinzler; M C Nilbert; Bert Vogelstein; T M Bryan; D B Levy; K J Smith; A C Preisinger; Stanley R Hamilton; P Hedge; A Markham
Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers.
Science (New York, N.Y.) 1991;251(4999):1366-70.
1991: J M Ruppert; Bert Vogelstein; Kenneth W Kinzler
The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A.
Molecular and cellular biology 1991;11(3):1724-8.
1991: J M Nigro; Kathleen R Cho; Eric R Fearon; Scott E Kern; J M Ruppert; J D Oliner; Kenneth W Kinzler; Bert Vogelstein
Scrambled exons.
Cell 1991;64(3):607-13.
1991: Scott E Kern; Kenneth W Kinzler; S J Baker; J M Nigro; V Rotter; Arnold J Levine; P Friedman; C Prives; Bert Vogelstein
Mutant p53 proteins bind DNA abnormally in vitro.
Oncogene 1991;6(1):131-6.
1991: Y Nakamura; I Nishisho; Kenneth W Kinzler; Bert Vogelstein; Y Miyoshi; Y Miki; H Ando; A Horii; H Nagase
Mutations of the adenomatous polyposis coli gene in familial polyposis coli patients and sporadic colorectal tumors.
Princess Takamatsu symposia 1991;22():285-92.
1990: S Paulien; C Turc-Carel; P Dal Cin; S Jani-Sait; C Sreekantaiah; S P Leong; Bert Vogelstein; Kenneth W Kinzler; Avery A Sandberg; Robert M Gemmill
Myxoid liposarcoma with t(12;16) (q13;p11) contains site-specific differences in methylation patterns surrounding a zinc-finger gene mapped to the breakpoint region on chromosome 12.
Cancer research 1990;50(24):7902-7.
1990: J M Ruppert; Bert Vogelstein; K Arheden; Kenneth W Kinzler
GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity.
Molecular and cellular biology 1990;10(10):5408-15.
1990: Kenneth W Kinzler; Bert Vogelstein
EcoRI polymorphism within the GLI gene (chromosome 12q13.3-14.1).
Nucleic acids research 1990;18(9):2834.
1990: Kenneth W Kinzler; Bert Vogelstein
The GLI gene encodes a nuclear protein which binds specific sequences in the human genome.
Molecular and cellular biology 1990;10(2):634-42.
1990: Eric R Fearon; Kathleen R Cho; J M Nigro; Scott E Kern; J W Simons; J M Ruppert; Stanley R Hamilton; A C Preisinger; G Thomas; Kenneth W Kinzler
Identification of a chromosome 18q gene that is altered in colorectal cancers.
Science (New York, N.Y.) 1990;247(4938):49-56.
1989: Kenneth W Kinzler; Bert Vogelstein
Whole genome PCR: application to the identification of sequences bound by gene regulatory proteins.
Nucleic acids research 1989;17(10):3645-53.
1989: K Arheden; M Rønne; Nils Mandahl; Sverre Heim; Kenneth W Kinzler; Bert Vogelstein; Felix Mitelman
In situ hybridization localizes the human putative oncogene GLI to chromosome subbands 12q13.3-14.1.
Human genetics 1989;82(1):1-2.
1988: J M Ruppert; Kenneth W Kinzler; A J Wong; S H Bigner; F T Kao; M L Law; H N Seuanez; S J O'Brien; Bert Vogelstein
The GLI-Kruppel family of human genes.
Molecular and cellular biology 1988;8(8):3104-13.
1988: Kenneth W Kinzler; J M Ruppert; S H Bigner; Bert Vogelstein
The GLI gene is a member of the Kruppel family of zinc finger proteins.
Nature 1988;332(6162):371-4.
1987: Sandra H Bigner; Albert J Wong; J Mark; L H Muhlbaier; Kenneth W Kinzler; Bert Vogelstein; Darell D Bigner
Relationship between gene amplification and chromosomal deviations in malignant human gliomas.
Cancer genetics and cytogenetics 1987;29(1):165-70.
1987: A J Wong; S H Bigner; D D Bigner; Kenneth W Kinzler; Stanley R Hamilton; Bert Vogelstein
Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(19):6899-903.
1987: Kenneth W Kinzler; S H Bigner; D D Bigner; Jeffrey M. Trent; M L Law; S J O'Brien; A J Wong; Bert Vogelstein
Identification of an amplified, highly expressed gene in a human glioma.
Science (New York, N.Y.) 1987;236(4797):70-3.
1986: Kenneth W Kinzler; B A Zehnbauer; G M Brodeur; Robert C Seeger; Jeffrey M. Trent; P S Meltzer; Bert Vogelstein
Amplification units containing human N-myc and c-myc genes.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(4):1031-5.
1986: Jeffrey M. Trent; Paul Meltzer; Mark L Rosenblum; G Harsh; Kenneth W Kinzler; R Mashal; Andrew P Feinberg; Bert Vogelstein
Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(2):470-3.
1986: Paul Meltzer; Kenneth W Kinzler; Bert Vogelstein; Jeffrey M. Trent
Gene amplification in cancer: a molecular cytogenetic approach.
Cancer genetics and cytogenetics 1986;19(1-2):93-9.