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Uwe Kirchhefer

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Calcium Signaling

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M A Tekook; E Zlotkin; Larissa Fabritz; P Kirchhof; S König; Frank U Müller; W Schmitz; T Tal; Uwe Kirchhefer
Gene construction, expression and functional testing of an inotropic peptide from the venom of the black scorpion Hottentotta judaicus.
Simon Kochhäuser; Eric Schulze-Bahr; Uwe Kirchhefer
Arrhythmia-associated cardiac Ca²(+) cycling proteins and gene mutations.
Dana Kučerová; Marek Mát'uš; Frank U Müller; Joachim Neumann; Wilhelm Schmitz; Hideo A Baba; Peter Bokník; Larissa Fabritz; Alexander Heinick; Uwe Kirchhefer
Modulation of SR Ca2+ release by the triadin-to-calsequestrin ratio in ventricular myocytes.

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All Publications

2012: M A Tekook; E Zlotkin; Larissa Fabritz; P Kirchhof; S König; Frank U Müller; W Schmitz; T Tal; Uwe Kirchhefer
Gene construction, expression and functional testing of an inotropic peptide from the venom of the black scorpion Hottentotta judaicus.
Toxicon : official journal of the International Society on Toxinology 2012;60(8):1415-27.
2012: Simon Kochhäuser; Eric Schulze-Bahr; Uwe Kirchhefer
Arrhythmia-associated cardiac Ca²(+) cycling proteins and gene mutations.
Wiener medizinische Wochenschrift (1946) 2012;162(13-14):292-6.
2012: Dana Kučerová; Marek Mát'uš; Frank U Müller; Joachim Neumann; Wilhelm Schmitz; Hideo A Baba; Peter Bokník; Larissa Fabritz; Alexander Heinick; Uwe Kirchhefer
Modulation of SR Ca2+ release by the triadin-to-calsequestrin ratio in ventricular myocytes.
American journal of physiology. Heart and circulatory physiology 2012;302(10):H2008-17.
2011: Paul J M Wijnker; Peter Boknik; Cris dos Remedios; Ulrich Gergs; Frank U Müller; Joachim Neumann; Wilhelm Schmitz; Jürgen R Sindermann; Ger J M Stienen; Jolanda van der Velden; Uwe Kirchhefer
Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium.
Journal of muscle research and cell motility 2011;32(3):221-33.
2011: Ulrich Gergs; Larry R Jones; Katharina Kiele-Dunsche; Uwe Kirchhefer; Igor B Buchwalow; Jan Buskase; Wilhelm Schmitz; Otto Traub; Joachim Neumann
Sarcoplasmic reticulum Ca2+ release in neonatal rat cardiac myocytes.
Journal of molecular and cellular cardiology 2011;51(5):682-8.
2010: Andreas Blana; Sven Kaese; Lisa Fortmüller; Sandra Laakmann; Dierk Damke; Kelly van Bragt; Jens Eckstein; Ilaria Piccini; Uwe Kirchhefer; Stanley Nattel; Günter Breithardt; Peter Carmeliet; Edward Carmeliet; Ulrich Schotten; Sander Verheule; Paulus Kirchhof; Larissa Fabritz
Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability.
Heart rhythm : the official journal of the Heart Rhythm Society 2010;7(12):1862-9.
2010: Cord Sunderkötter; Uwe Kirchhefer
[Limited toxicity of the pediculicides pyrethrin, pyrethroids, and permethrin].
Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete 2010;61(10):906-9.
2010: Uwe Kirchhefer; Diana Wehrmeister; Alex V Postma; Gottfried Pohlentz; Michael Mormann; Dana Kucerova; Frank U Müller; Wilhelm Schmitz; Eric Schulze-Bahr; Arthur A Wilde; Joachim Neumann
The human CASQ2 mutation K206N is associated with hyperglycosylation and altered cellular calcium handling.
Journal of molecular and cellular cardiology 2010;49(1):95-105.
2010: Larissa Fabritz; Dierk Damke; Markus Emmerich; Susann G Kaufmann; Kathrin Theis; Andreas Blana; Lisa Fortmüller; Sandra Laakmann; Sven Hermann; Elena Aleynichenko; Johannes Steinfurt; Daniela Volkery; Burkhard Riemann; Uwe Kirchhefer; Michael R Franz; Günter Breithardt; Edward Carmeliet; Michael Schäfers; Sebastian K G Maier; Peter Carmeliet; Paulus Kirchhof
Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3.
Cardiovascular research 2010;87(1):60-72.
2010: Josef Krieglstein; Tobias Kewitz; Uwe Kirchhefer; Oliver Hofnagel; Gabriele Weissen-Plenz; Michael Reinbold; Susanne Klumpp
Damage of guinea pig heart and arteries by a trioleate-enriched diet and of cultured cardiomyocytes by oleic acid.
PloS one 2010;5(3):e9561.
2008: Alexander Peter Schwoerer; Christiane Neuber; Ariane Schmechel; Ivan Melnychenko; Giulia Mearini; Peter Boknik; Uwe Kirchhefer; Wilhelm Schmitz; Heimo Ehmke; Thomas Eschenhagen; Ali El-Armouche
Mechanical unloading of the rat heart involves marked changes in the protein kinase-phosphatase balance.
Journal of molecular and cellular cardiology 2008;45(6):846-52.
2008: Nicole Brüchert; Nirmala Mavila; Peter Boknik; Hideo A Baba; Larissa Fabritz; Ulrich Gergs; Uwe Kirchhefer; Paulus Kirchhof; Marek Matus; Wilhelm Schmitz; Anna A DePaoli-Roach; Joachim Neumann
Inhibitor-2 prevents protein phosphatase 1-induced cardiac hypertrophy and mortality.
American journal of physiology. Heart and circulatory physiology 2008;295(4):H1539-46.
2008: Stephanie Grote-Wessels; Hideo A Baba; Peter Boknik; Ali El-Armouche; Larissa Fabritz; Hans-Jörg Gillmann; Dana Kucerova; Marek Matus; Frank U Müller; Joachim Neumann; Martina Schmitz; Frank Stümpel; Gregor Theilmeier; Jeremias Wohlschlaeger; Wilhelm Schmitz; Uwe Kirchhefer
Inhibition of protein phosphatase 1 by inhibitor-2 exacerbates progression of cardiac failure in a model with pressure overload.
Cardiovascular research 2008;79(3):464-71.
2007: Uwe Kirchhefer; Jan Klimas; Hideo A Baba; Igor B Buchwalow; Larissa Fabritz; Marion Hüls; Marek Matus; Frank U Müller; Wilhelm Schmitz; Joachim Neumann
Triadin is a critical determinant of cellular Ca cycling and contractility in the heart.
American journal of physiology. Heart and circulatory physiology 2007;293(5):H3165-74.
2007: Ulrich Gergs; Tobias Berndt; Jan Buskase; Larry R Jones; Uwe Kirchhefer; Frank U Müller; Klaus-Dieter Schlüter; Wilhelm Schmitz; Joachim Neumann
On the role of junctin in cardiac Ca2+ handling, contractility, and heart failure.
American journal of physiology. Heart and circulatory physiology 2007;293(1):H728-34.
2007: Paulus Kirchhof; Jan Klimas; Larissa Fabritz; Melanie Zwiener; Larry R Jones; Michael Schäfers; Sven Hermann; Peter Boknik; Wilhelm Schmitz; Günter Breithardt; Uwe Kirchhefer; Joachim Neumann
Stress and high heart rate provoke ventricular tachycardia in mice expressing triadin.
Journal of molecular and cellular cardiology 2007;42(5):962-71.
2006: Uwe Kirchhefer; Gabriela Hanske; Larry R Jones; Isabel Justus; Lars Kaestner; Peter Lipp; Wilhelm Schmitz; Joachim Neumann
Overexpression of junctin causes adaptive changes in cardiac myocyte Ca(2+) signaling.
Cell calcium 2006;39(2):131-42.
2005: Uwe Kirchhefer; Hideo A Baba; Peter Bokník; Kristine M Breeden; Nirmala Mavila; Nicole Brüchert; Isabel Justus; Marek Matus; Wilhelm Schmitz; Anna A DePaoli-Roach; Joachim Neumann
Enhanced cardiac function in mice overexpressing protein phosphatase Inhibitor-2.
Cardiovascular research 2005;68(1):98-108.
2005: Frank U Müller; Geertje Lewin; Hideo A Baba; Peter Bokník; Larissa Fabritz; Uwe Kirchhefer; Paulus Kirchhof; Karin Loser; Marek Matus; Joachim Neumann; Burkhard Riemann; Wilhelm Schmitz
Heart-directed expression of a human cardiac isoform of cAMP-response element modulator in transgenic mice.
The Journal of biological chemistry 2005;280(8):6906-14.
2004: Uwe Kirchhefer; Hideo A Baba; Gabriela Hanske; Larry R Jones; Paulus Kirchhof; Wilhelm Schmitz; Joachim Neumann
Age-dependent biochemical and contractile properties in atrium of transgenic mice overexpressing junctin.
American journal of physiology. Heart and circulatory physiology 2004;287(5):H2216-25.
2004: Uwe Kirchhefer; Larry R Jones; Frank Begrow; Peter Boknik; Lutz Hein; Martin J Lohse; Burkhard Riemann; Wilhelm Schmitz; Jörg Stypmann; Joachim Neumann
Transgenic triadin 1 overexpression alters SR Ca2+ handling and leads to a blunted contractile response to beta-adrenergic agonists.
Cardiovascular research 2004;62(1):122-34.
2003: Burkhard Riemann; Marilyn P Law; Klaus Kopka; St Wagner; Sajinder K Luthra; Victor W Pike; Joachim Neumann; Uwe Kirchhefer; Wilhelm Schmitz; Otmar Schober; Michael Schäfers
[High non-specific binding of the beta(1) -selective radioligand 2-(125)I-ICI-H].
Nuklearmedizin. Nuclear medicine 2003;42(4):173-80.
2003: Uwe Kirchhefer; Joachim Neumann; Donald M Bers; Igor B Buchwalow; Larissa Fabritz; Gabriela Hanske; Isabel Justus; Burkhard Riemann; Wilhelm Schmitz; Larry R Jones
Impaired relaxation in transgenic mice overexpressing junctin.
Cardiovascular research 2003;59(2):369-79.
2002: Uwe Kirchhefer; Hideo A Baba; Yvonne M Kobayashi; Larry R Jones; Wilhelm Schmitz; Joachim Neumann
Altered function in atrium of transgenic mice overexpressing triadin 1.
American journal of physiology. Heart and circulatory physiology 2002;283(4):H1334-43.
2002: Frank U Müller; Uwe Kirchhefer; Frank Begrow; Uta Reinke; Joachim Neumann; Wilhelm Schmitz
Junctional sarcoplasmic reticulum transmembrane proteins in the heart.
Basic research in cardiology 2002;97 Suppl 1():I52-5.
2001: Peter Bokník; I Heinroth-Hoffmann; Uwe Kirchhefer; Jörg Knapp; Bettina Linck; Hartmut Lüss; T Müller; Wilhelm Schmitz; Otto-Erich Brodde; Joachim Neumann
Enhanced protein phosphorylation in hypertensive hypertrophy.
Cardiovascular research 2001;51(4):717-28.
2001: Uwe Kirchhefer; Joachim Neumann; Hideo A Baba; Frank Begrow; Y M Kobayashi; Uta Reinke; Wilhelm Schmitz; Larry R Jones
Cardiac hypertrophy and impaired relaxation in transgenic mice overexpressing triadin 1.
The Journal of biological chemistry 2001;276(6):4142-9.
2000: Bettina Linck; Peter Bokník; S Huke; Uwe Kirchhefer; Jörg Knapp; Hartmut Lüss; Frank U Müller; Joachim Neumann; Z Tanriseven; U Vahlensieck; Hideo A Baba; Larry R Jones; K D Philipson; Wilhelm Schmitz
Functional properties of transgenic mouse hearts overexpressing both calsequestrin and the Na(+)-Ca(2+) exchanger.
The Journal of pharmacology and experimental therapeutics 2000;294(2):648-57.
2000: Hartmut Lüss; Andreas Meissner; Norbert Rolf; Hugo Van Aken; Peter Bokník; Uwe Kirchhefer; Jörg Knapp; S Läer; Bettina Linck; I Lüss; Frank U Müller; Joachim Neumann; Wilhelm Schmitz
Biochemical mechanism(s) of stunning in conscious dogs.
American journal of physiology. Heart and circulatory physiology 2000;279(1):H176-84.
2000: Andreas Meissner; I Lüss; Norbert Rolf; Peter Boknik; Uwe Kirchhefer; V Kehm; Jörg Knapp; Bettina Linck; Hartmut Lüss; Frank U Müller; Thomas Weber; Wilhelm Schmitz; Hugo Van Aken; Joachim Neumann
The early response genes c-jun and HSP-70 are induced in regional cardiac stunning in conscious mammals.
The Journal of thoracic and cardiovascular surgery 2000;119(4 Pt 1):820-5.
1999: Peter Bokník; C Unkel; Uwe Kirchhefer; U Kleideiter; O Klein-Wiele; Jörg Knapp; Bettina Linck; Hartmut Lüss; Frank U Müller; Wilhelm Schmitz; U Vahlensieck; N Zimmermann; Larry R Jones; Joachim Neumann
Regional expression of phospholamban in the human heart.
Cardiovascular research 1999;43(1):67-76.
1999: I Lüss; Peter Boknik; Larry R Jones; Uwe Kirchhefer; Jörg Knapp; Bettina Linck; Hartmut Lüss; Andreas Meissner; Frank U Müller; Wilhelm Schmitz; U Vahlensieck; Joachim Neumann
Expression of cardiac calcium regulatory proteins in atrium v ventricle in different species.
Journal of molecular and cellular cardiology 1999;31(6):1299-314.
1999: Uwe Kirchhefer; Wilhelm Schmitz; H Scholz; Joachim Neumann
Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts.
Cardiovascular research 1999;42(1):254-61.
1998: Bettina Linck; Peter Bokník; Hideo A Baba; Thomas Eschenhagen; Uwe Haverkamp; Elmar Jäckel; Larry R Jones; Uwe Kirchhefer; Jörg Knapp; S Läer; Frank U Müller; Wilhelm Schmitz; H Scholz; A Syska; U Vahlensieck; Joachim Neumann
Long-term beta adrenoceptor-mediated alteration in contractility and expression of phospholamban and sarcoplasmic reticulum Ca(++)-ATPase in mammalian ventricle.
The Journal of pharmacology and experimental therapeutics 1998;286(1):531-8.
1998: I Gombosova; Peter Boknik; Uwe Kirchhefer; Jörg Knapp; H Luss; F U Muller; T Muller; U Vahlensieck; Wilhelm Schmitz; G S Bodor; Joachim Neumann
Postnatal changes in contractile time parameters, calcium regulatory proteins, and phosphatases.
The American journal of physiology 1998;274(6 Pt 2):H2123-32.