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Mary Lynn Bajt

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Mitchell R McGill; Hye-Ryun K Norris; Douglas E Rollins; Matthew H Slawson; Diana G Wilkins; C David Williams; Yuchao Xie; Mary Lynn Bajt; Margitta Lebofsky; Hartmut Jaeschke
Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose-response, mechanisms, and clinical implications.
Benjamin L Woolbright; Hui-min Yan; Mary Lynn Bajt; John J Lemasters; Mitchell R McGill; Anup Ramachandran; Matthew R Sharpe; Hartmut Jaeschke
Lysosomal instability and cathepsin B release during acetaminophen hepatotoxicity.
Mary Lynn Bajt; Anwar Farhood; Margitta Lebofsky; John J Lemasters; Anup Ramachandran; Hui-Min Yan; Hartmut Jaeschke
Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.

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All Publications

2013: Mitchell R McGill; Hye-Ryun K Norris; Douglas E Rollins; Matthew H Slawson; Diana G Wilkins; C David Williams; Yuchao Xie; Mary Lynn Bajt; Margitta Lebofsky; Hartmut Jaeschke
Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose-response, mechanisms, and clinical implications.
Toxicology and applied pharmacology 2013;269(3):240-9.
2012: Benjamin L Woolbright; Hui-min Yan; Mary Lynn Bajt; John J Lemasters; Mitchell R McGill; Anup Ramachandran; Matthew R Sharpe; Hartmut Jaeschke
Lysosomal instability and cathepsin B release during acetaminophen hepatotoxicity.
Basic & clinical pharmacology & toxicology 2012;111(6):417-25.
2011: Mary Lynn Bajt; Anwar Farhood; Margitta Lebofsky; John J Lemasters; Anup Ramachandran; Hui-Min Yan; Hartmut Jaeschke
Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2011;122(2):598-605.
2010: Hui-Min Yan; Anup Ramachandran; Mary Lynn Bajt; John J Lemasters; Hartmut Jaeschke
The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes.
Toxicological sciences : an official journal of the Society of Toxicology 2010;117(2):515-23.
2010: Clarence David Williams; Mary Lynn Bajt; Anwar Farhood; Hartmut Jaeschke
Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice.
Liver international : official journal of the International Association for the Study of the Liver 2010;30(9):1280-92.
2008: Mary Lynn Bajt; Hui-Min Yan; Anwar Farhood; Hartmut Jaeschke
Plasminogen activator inhibitor-1 limits liver injury and facilitates regeneration after acetaminophen overdose.
Toxicological sciences : an official journal of the Society of Toxicology 2008;104(2):419-27.
2008: Kelly K Andringa; Mary Lynn Bajt; Hartmut Jaeschke; Shannon M Bailey
Mitochondrial protein thiol modifications in acetaminophen hepatotoxicity: effect on HMG-CoA synthase.
Toxicology letters 2008;177(3):188-97.
2008: Mary Lynn Bajt; Anwar Farhood; John J Lemasters; Hartmut Jaeschke
Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity.
The Journal of pharmacology and experimental therapeutics 2008;324(1):8-14.
2006: Mary Lynn Bajt; Cathleen Cover; John J Lemasters; Hartmut Jaeschke
Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury.
Toxicological sciences : an official journal of the Society of Toxicology 2006;94(1):217-25.
2006: Cathleen Cover; Jie Liu; Anwar Farhood; Ernst Malle; Michael P Waalkes; Mary Lynn Bajt; Hartmut Jaeschke
Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity.
Toxicology and applied pharmacology 2006;216(1):98-107.
2006: Hartmut Jaeschke; Cathleen Cover; Mary Lynn Bajt
Role of caspases in acetaminophen-induced liver injury.
Life sciences 2006;78(15):1670-6.
2006: Hartmut Jaeschke; Mary Lynn Bajt
Intracellular signaling mechanisms of acetaminophen-induced liver cell death.
Toxicological sciences : an official journal of the Society of Toxicology 2006;89(1):31-41.
2005: Cathleen Cover; Abdellah Mansouri; Tamara R Knight; Mary Lynn Bajt; John J Lemasters; Dominique Pessayre; Hartmut Jaeschke
Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity.
The Journal of pharmacology and experimental therapeutics 2005;315(2):879-87.
2005: Robert B Dorman; Jaspreet S Gujral; Mary Lynn Bajt; Anwar Farhood; Hartmut Jaeschke
Generation and functional significance of CXC chemokines for neutrophil-induced liver injury during endotoxemia.
American journal of physiology. Gastrointestinal and liver physiology 2005;288(5):G880-6.
2004: Hartmut Jaeschke; Mary Lynn Bajt
Critical role of CXC chemokines in endotoxemic liver injury in mice.
Journal of leukocyte biology 2004;76(6):1089-90; author reply 1091-2.
2004: Mary Lynn Bajt; Tamara R Knight; John J Lemasters; Hartmut Jaeschke
Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine.
Toxicological sciences : an official journal of the Society of Toxicology 2004;80(2):343-9.
2004: Hartmut Jaeschke; Jaspreet S Gujral; Mary Lynn Bajt
Apoptosis and necrosis in liver disease.
Liver international : official journal of the International Association for the Study of the Liver 2004;24(2):85-9.
2003: Hartmut Jaeschke; Tamara R Knight; Mary Lynn Bajt
The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity.
Toxicology letters 2003;144(3):279-88.
2003: Mary Lynn Bajt; Tamara R Knight; Anwar Farhood; Hartmut Jaeschke
Scavenging peroxynitrite with glutathione promotes regeneration and enhances survival during acetaminophen-induced liver injury in mice.
The Journal of pharmacology and experimental therapeutics 2003;307(1):67-73.
2003: Jaspreet S Gujral; Anwar Farhood; Mary Lynn Bajt; Hartmut Jaeschke
Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice.
Hepatology (Baltimore, Md.) 2003;38(2):355-63.
2003: Hartmut Jaeschke; Mary Lynn Bajt
Regulation of apoptotic signaling pathways in hepatocytes in vivo.
Hepatology (Baltimore, Md.) 2003;37(4):942-5.
2002: Mary Lynn Bajt; Ye-Shih Ho; Steven L Vonderfecht; Hartmut Jaeschke
Reactive oxygen as modulator of TNF and fas receptor-mediated apoptosis in vivo: studies with glutathione peroxidase-deficient mice.
Antioxidants & redox signaling 2002;4(5):733-40.
2002: Jaspreet S Gujral; Tamara R Knight; Anwar Farhood; Mary Lynn Bajt; Hartmut Jaeschke
Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis?
Toxicological sciences : an official journal of the Society of Toxicology 2002;67(2):322-8.
2001: Mary Lynn Bajt; Anwar Farhood; Hartmut Jaeschke
Effects of CXC chemokines on neutrophil activation and sequestration in hepatic vasculature.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(5):G1188-95.
2001: Mary Lynn Bajt; Steven L Vonderfecht; Hartmut Jaeschke
Differential protection with inhibitors of caspase-8 and caspase-3 in murine models of tumor necrosis factor and Fas receptor-mediated hepatocellular apoptosis.
Toxicology and applied pharmacology 2001;175(3):243-52.
2001: Tamara R Knight; A Kurtz; Mary Lynn Bajt; Jack A Hinson; Hartmut Jaeschke
Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: role of mitochondrial oxidant stress.
Toxicological sciences : an official journal of the Society of Toxicology 2001;62(2):212-20.
2000: Hartmut Jaeschke; Anwar Farhood; S X Cai; B Y Tseng; Mary Lynn Bajt
Protection against TNF-induced liver parenchymal cell apoptosis during endotoxemia by a novel caspase inhibitor in mice.
Toxicology and applied pharmacology 2000;169(1):77-83.
2000: Mary Lynn Bajt; JA Lawson; Steven L Vonderfecht; Jaspreet S Gujral; Hartmut Jaeschke
Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a postmitochondrial processing of caspase-8.
Toxicological sciences : an official journal of the Society of Toxicology 2000;58(1):109-17.
2000: JA Lawson; Anwar Farhood; R D Hopper; Mary Lynn Bajt; Hartmut Jaeschke
The hepatic inflammatory response after acetaminophen overdose: role of neutrophils.
Toxicological sciences : an official journal of the Society of Toxicology 2000;54(2):509-16.
1997: NA Essani; Mary Lynn Bajt; Anwar Farhood; Steven L Vonderfecht; Hartmut Jaeschke
Transcriptional activation of vascular cell adhesion molecule-1 gene in vivo and its role in the pathophysiology of neutrophil-induced liver injury in murine endotoxin shock.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(12):5941-8.