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Karla Kirkegaard

Research Profile

Living Beings

Poliovirus

Chemicals & Drugs

Anatomy

Physiology

Concepts & Ideas

Disorders

Poliomyelitis

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Publications

TOP 3
J Antonio Gomez; Smita Gopinath; Michel Brahic; Jean-François Bureau; Howard Y Chang; Denise M Monack; Orly L Wapinski; Yul W Yang; Karla Kirkegaard
The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-γ locus.
Eric C Freundt; Karla Kirkegaard; Nate Maynard; Ronald Melki; Shyamali Roy; Yannick Sourigues; Luc Bousset; Eileen K Clancy; Markus Covert; Michel Brahic
Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport.
Nathaniel D Maynard; Karla Kirkegaard; Derek N Macklin; Markus W Covert
Competing pathways control host resistance to virus via tRNA modification and programmed ribosomal frameshifting.

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All Publications

2013: J Antonio Gomez; Smita Gopinath; Michel Brahic; Jean-François Bureau; Howard Y Chang; Denise M Monack; Orly L Wapinski; Yul W Yang; Karla Kirkegaard
The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-γ locus.
Cell 2013;152(4):743-54.
2012: Eric C Freundt; Karla Kirkegaard; Nate Maynard; Ronald Melki; Shyamali Roy; Yannick Sourigues; Luc Bousset; Eileen K Clancy; Markus Covert; Michel Brahic
Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport.
Annals of neurology 2012;72(4):517-24.
2012: Nathaniel D Maynard; Karla Kirkegaard; Derek N Macklin; Markus W Covert
Competing pathways control host resistance to virus via tRNA modification and programmed ribosomal frameshifting.
Molecular systems biology 2012;8():567.
2011: Andres B Tellez; Jing Wang; Karla Kirkegaard; Jeannie F. Spagnolo; Elizabeth J Tanner; Esther Bullitt
Interstitial contacts in an RNA-dependent RNA polymerase lattice.
Journal of molecular biology 2011;412(4):737-50.
2010: Poornima Parameswaran; Ella Sklan; Courtney Wilkins; Trever Burgon; Melanie A Samuel; Rui Lu; K Mark Ansel; Vigo Heissmeyer; Shirit Einav; William Jackson; Tammy Doukas; Suman Paranjape; Charlotta Polacek; Flavia Barreto dos Santos; Roxana Jalili; Farbod Babrzadeh; Baback Gharizadeh; Dirk Grimm; Mark Kay; Satoshi Koike; Peter Sarnow; Mostafa Ronaghi; Shou-Wei Ding; Eva Harris; Marie Chow; Michael S Diamond; Karla Kirkegaard; Jeffrey S Glenn; Andrew Z Fire
Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems.
PLoS pathogens 2010;6(2):e1000764.
2010: Jeannie F. Spagnolo; Evan Rossignol; Esther Bullitt; Karla Kirkegaard
Enzymatic and nonenzymatic functions of viral RNA-dependent RNA polymerases within oligomeric arrays.
RNA (New York, N.Y.) 2010;16(2):382-93.
2009: Trever B Burgon; Jomaquai A Jenkins; Stephen B Deitz; Jeannie F. Spagnolo; Karla Kirkegaard
Bypass suppression of small-plaque phenotypes by a mutation in poliovirus 2A that enhances apoptosis.
Journal of virology 2009;83(19):10129-39.
2009: Matthew P Taylor; Trever B Burgon; Karla Kirkegaard; William T Jackson
Role of microtubules in extracellular release of poliovirus.
Journal of virology 2009;83(13):6599-609.
2009: Karla Kirkegaard
Subversion of the cellular autophagy pathway by viruses.
Current topics in microbiology and immunology 2009;335():323-33.
2008: Matthew P Taylor; Karla Kirkegaard
Potential subversion of autophagosomal pathway by picornaviruses.
Autophagy 2008;4(3):286-9.
2007: Matthew P Taylor; Karla Kirkegaard
Modification of cellular autophagy protein LC3 by poliovirus.
Journal of virology 2007;81(22):12543-53.
2007: Oren Beske; Mike Reichelt; Matthew P Taylor; Karla Kirkegaard; Raul Andino
Poliovirus infection blocks ERGIC-to-Golgi trafficking and induces microtubule-dependent disruption of the Golgi complex.
Journal of cell science 2007;120(Pt 18):3207-18.
2006: Oliver C Richards; Jeannie F. Spagnolo; John M Lyle; Susan E Vleck; Robert D Kuchta; Karla Kirkegaard
Intramolecular and intermolecular uridylylation by poliovirus RNA-dependent RNA polymerase.
Journal of virology 2006;80(15):7405-15.
2006: Julie K Pfeiffer; Karla Kirkegaard
Bottleneck-mediated quasispecies restriction during spread of an RNA virus from inoculation site to brain.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(14):5520-5.
2006: Andres B Tellez; Scott Crowder; Jeannie F. Spagnolo; Aaron A Thompson; Olve B Peersen; Douglas L Brutlag; Karla Kirkegaard
Nucleotide channel of RNA-dependent RNA polymerase used for intermolecular uridylylation of protein primer.
Journal of molecular biology 2006;357(2):665-75.
2005: Karla Kirkegaard; William T Jackson
Topology of double-membraned vesicles and the opportunity for non-lytic release of cytoplasm.
Autophagy 2005;1(3):182-4.
2005: Julie K Pfeiffer; Karla Kirkegaard
Increased fidelity reduces poliovirus fitness and virulence under selective pressure in mice.
PLoS pathogens 2005;1(2):e11.
2005: Scott Crowder; Karla Kirkegaard
Trans-dominant inhibition of RNA viral replication can slow growth of drug-resistant viruses.
Nature genetics 2005;37(7):701-9.
2005: Sunny S Choe; Dana A Dodd; Karla Kirkegaard
Inhibition of cellular protein secretion by picornaviral 3A proteins.
Virology 2005;337(1):18-29.
2005: Joanna E Boerner; John M Lyle; Sarah Daijogo; Bert L Semler; Steve C Schultz; Karla Kirkegaard; Oliver C Richards
Allosteric effects of ligands and mutations on poliovirus RNA-dependent RNA polymerase.
Journal of virology 2005;79(12):7803-11.
2005: William T Jackson; Thomas H Giddings; Matthew P Taylor; Sara Mulinyawe; Marlene Rabinovitch; Ron R Kopito; Karla Kirkegaard
Subversion of cellular autophagosomal machinery by RNA viruses.
PLoS biology 2005;3(5):e156.
2005: Julie K Pfeiffer; Karla Kirkegaard
Ribavirin resistance in hepatitis C virus replicon-containing cell lines conferred by changes in the cell line or mutations in the replicon RNA.
Journal of virology 2005;79(4):2346-55.
2004: Scott Crowder; Karla Kirkegaard
Complete three-dimensional structures of picornaviral RNA-dependent RNA polymerases.
Structure (London, England : 1993) 2004;12(8):1336-9.
2004: Sunny S Choe; Karla Kirkegaard
Intracellular topology and epitope shielding of poliovirus 3A protein.
Journal of virology 2004;78(11):5973-82.
2004: Karla Kirkegaard; Matthew P Taylor; William T Jackson
Cellular autophagy: surrender, avoidance and subversion by microorganisms.
Nature reviews. Microbiology 2004;2(4):301-14.
2003: Kouacou V Konan; Thomas H Giddings; Masanori Ikeda; Kui Li; Stanley M Lemon; Karla Kirkegaard
Nonstructural protein precursor NS4A/B from hepatitis C virus alters function and ultrastructure of host secretory apparatus.
Journal of virology 2003;77(14):7843-55.
2003: Julie K Pfeiffer; Karla Kirkegaard
A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(12):7289-94.
2002: John M Lyle; Esther Bullitt; Kurt Bienz; Karla Kirkegaard
Visualization and functional analysis of RNA-dependent RNA polymerase lattices.
Science (New York, N.Y.) 2002;296(5576):2218-22.
2002: John M Lyle; Amy Clewell; Kathryn E. Richmond; Oliver C Richards; Debra A Hope; Steve C Schultz; Karla Kirkegaard
Similar structural basis for membrane localization and protein priming by an RNA-dependent RNA polymerase.
The Journal of biological chemistry 2002;277(18):16324-31.
2002: Q May Wang; Michelle Hockman; Kirk Staschke; Robert B Johnson; Katharine A Case; Jirong Lu; Steve Parsons; Faming Zhang; Radhakrishnan Rathnachalam; Karla Kirkegaard; Joseph Colacino
Oligomerization and cooperative RNA synthesis activity of hepatitis C virus RNA-dependent RNA polymerase.
Journal of virology 2002;76(8):3865-72.
2001: Dana A Dodd; Thomas H Giddings; Karla Kirkegaard
Poliovirus 3A protein limits interleukin-6 (IL-6), IL-8, and beta interferon secretion during viral infection.
Journal of virology 2001;75(17):8158-65.
2001: S D Hobson; E S Rosenblum; Oliver C Richards; Kathryn E. Richmond; Karla Kirkegaard; Steve C Schultz
Oligomeric structures of poliovirus polymerase are important for function.
The EMBO journal 2001;20(5):1153-63.
2000: S B Deitz; Dana A Dodd; Scott Cooper; Peter Parham; Karla Kirkegaard
MHC I-dependent antigen presentation is inhibited by poliovirus protein 3A.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(25):13790-5.
2000: D A Suhy; Thomas H Giddings; Karla Kirkegaard
Remodeling the endoplasmic reticulum by poliovirus infection and by individual viral proteins: an autophagy-like origin for virus-induced vesicles.
Journal of virology 2000;74(19):8953-65.
1999: C I Nugent; K L Johnson; P Sarnow; Karla Kirkegaard
Functional coupling between replication and packaging of poliovirus replicon RNA.
Journal of virology 1999;73(1):427-35.
1998: A E McBride; Stephen J Taylor; David Shalloway; Karla Kirkegaard
KH domain integrity is required for wild-type localization of Sam68.
Experimental cell research 1998;241(1):84-95.
1998: M T Beckman; Karla Kirkegaard
Site size of cooperative single-stranded RNA binding by poliovirus RNA-dependent RNA polymerase.
The Journal of biological chemistry 1998;273(12):6724-30.
1997: Debra A Hope; Scott E Diamond; Karla Kirkegaard
Genetic dissection of interaction between poliovirus 3D polymerase and viral protein 3AB.
Journal of virology 1997;71(12):9490-8.
1997: J R Doedens; Thomas H Giddings; Karla Kirkegaard
Inhibition of endoplasmic reticulum-to-Golgi traffic by poliovirus protein 3A: genetic and ultrastructural analysis.
Journal of virology 1997;71(12):9054-64.
1997: Roderick S Tang; David J Barton; James B Flanegan; Karla Kirkegaard
Poliovirus RNA recombination in cell-free extracts.
RNA (New York, N.Y.) 1997;3(6):624-33.
1997: Frank J M van Kuppeveld; Willem J G Melchers; Karla Kirkegaard; J R Doedens
Structure-function analysis of coxsackie B3 virus protein 2B.
Virology 1997;227(1):111-8.
1996: A Schlegel; Thomas H Giddings; M S Ladinsky; Karla Kirkegaard
Cellular origin and ultrastructure of membranes induced during poliovirus infection.
Journal of virology 1996;70(10):6576-88.
1996: A E McBride; A Schlegel; Karla Kirkegaard
Human protein Sam68 relocalization and interaction with poliovirus RNA polymerase in infected cells.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(6):2296-301.
1995: J D Pata; S C Schultz; Karla Kirkegaard
Functional oligomerization of poliovirus RNA-dependent RNA polymerase.
RNA (New York, N.Y.) 1995;1(5):466-77.
1995: J R Doedens; Karla Kirkegaard
Inhibition of cellular protein secretion by poliovirus proteins 2B and 3A.
The EMBO journal 1995;14(5):894-907.
1995: C I Nugent; Karla Kirkegaard
RNA binding properties of poliovirus subviral particles.
Journal of virology 1995;69(1):13-22.
1994: J E Novak; Karla Kirkegaard
Coupling between genome translation and replication in an RNA virus.
Genes & development 1994;8(14):1726-37.
1994: Scott E Diamond; Karla Kirkegaard
Clustered charged-to-alanine mutagenesis of poliovirus RNA-dependent RNA polymerase yields multiple temperature-sensitive mutants defective in RNA synthesis.
Journal of virology 1994;68(2):863-76.
1994: J Doedens; L A Maynell; Michael Klymkowsky; Karla Kirkegaard
Secretory pathway function, but not cytoskeletal integrity, is required in poliovirus infection.
Archives of virology. Supplementum 1994;9():159-72.
1992: T C Jarvis; Karla Kirkegaard
Poliovirus RNA recombination: mechanistic studies in the absence of selection.
The EMBO journal 1992;11(8):3135-45.
1992: L A Maynell; Karla Kirkegaard; Michael Klymkowsky
Inhibition of poliovirus RNA synthesis by brefeldin A.
Journal of virology 1992;66(4):1985-94.
1992: Karla Kirkegaard
Genetic analysis of picornaviruses.
Current opinion in genetics & development 1992;2(1):64-70.
1991: P J Russell; S J Hambidge; Karla Kirkegaard
Direct introduction and transient expression of capped and non-capped RNA in Saccharomyces cerevisiae.
Nucleic acids research 1991;19(18):4949-53.
1991: L M Morrissey; Karla Kirkegaard
Regulation of a double-stranded RNA modification activity in human cells.
Molecular and cellular biology 1991;11(7):3719-25.
1991: J E Novak; Karla Kirkegaard
Improved method for detecting poliovirus negative strands used to demonstrate specificity of positive-strand encapsidation and the ratio of positive to negative strands in infected cells.
Journal of virology 1991;65(6):3384-7.
1991: T C Jarvis; Karla Kirkegaard
The polymerase in its labyrinth: mechanisms and implications of RNA recombination.
Trends in genetics : TIG 1991;7(6):186-91.
1991: J Pata; Karla Kirkegaard
Poliovirus RNA recombination.
SAAS bulletin, biochemistry and biotechnology 1991;4():20-1.
1990: S R Compton; B Nelsen; Karla Kirkegaard
Temperature-sensitive poliovirus mutant fails to cleave VP0 and accumulates provirions.
Journal of virology 1990;64(9):4067-75.
1990: Karla Kirkegaard
Mutations in VP1 of poliovirus specifically affect both encapsidation and release of viral RNA.
Journal of virology 1990;64(1):195-206.
1990: Karla Kirkegaard; B Nelsen
Conditional poliovirus mutants made by random deletion mutagenesis of infectious cDNA.
Journal of virology 1990;64(1):185-94.