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Robert Kirken

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Chemicals & Drugs

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Heart Transplantation

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TOP 3
Georgialina Rodriguez; Jeremy A Ross; Zsuzsanna S Nagy; Robert A Kirken
Forskolin-inducible cAMP pathway negatively regulates T-cell proliferation by uncoupling the interleukin-2 receptor complex.
Zsuzsanna S Nagy; Georgialina Rodriguez; Jeremy A Ross; Lajos Szeles; Balint L Balint; Laszlo Nagy; Robert A Kirken
Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid cancer cells.
Jeremy A Ross; Georgialina Rodriguez; Robert A Kirken
Analysis of Janus tyrosine kinase phosphorylation and activation.

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All Publications

2013: Georgialina Rodriguez; Jeremy A Ross; Zsuzsanna S Nagy; Robert A Kirken
Forskolin-inducible cAMP pathway negatively regulates T-cell proliferation by uncoupling the interleukin-2 receptor complex.
The Journal of biological chemistry 2013;288(10):7137-46.
2013: Zsuzsanna S Nagy; Georgialina Rodriguez; Jeremy A Ross; Lajos Szeles; Balint L Balint; Laszlo Nagy; Robert A Kirken
Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid cancer cells.
PloS one 2013;8(2):e57326.
2013: Jeremy A Ross; Georgialina Rodriguez; Robert A Kirken
Analysis of Janus tyrosine kinase phosphorylation and activation.
Methods in molecular biology (Clifton, N.J.) 2013;967():3-20.
2012: Abhisek Mitra; Zsuzsanna S Nagy; Georgialina Rodriguez; Jeremy A Ross; Harry L Wilson; Robert A Kirken
Signal transducer and activator of transcription 5b (Stat5b) serine 193 is a novel cytokine-induced phospho-regulatory site that is constitutively activated in primary hematopoietic malignancies.
The Journal of biological chemistry 2012;287(20):16596-608.
2010: Zsuzsanna S Nagy; Jeremy A Ross; Georgialina Rodriguez; Julia Bader; Jonathan Dimmock; Robert A Kirken
Uncoupling JAK3 activation induces apoptosis in human lymphoid cancer cells via regulating critical survival pathways.
FEBS letters 2010;584(8):1515-20.
2010: Jeremy A Ross; Hanyin Cheng; Zsuzsanna S Nagy; Jeffrey A Frost; Robert A Kirken
Protein phosphatase 2A regulates interleukin-2 receptor complex formation and JAK3/STAT5 activation.
The Journal of biological chemistry 2010;285(6):3582-91.
2009: Zsuzsanna S Nagy; Matthew J LeBaron; Jeremy A Ross; Abhisek Mitra; Hallgeir Rui; Robert A Kirken
STAT5 regulation of BCL10 parallels constitutive NFkappaB activation in lymphoid tumor cells.
Molecular cancer 2009;8():67.
2008: Stanislaw M Stepkowski; Wenhao Chen; Jeremy A Ross; Zsuzsanna S Nagy; Robert A Kirken
STAT3: an important regulator of multiple cytokine functions.
Transplantation 2008;85(10):1372-7.
2008: Hanyin Cheng; Jeremy A Ross; Jeffrey A Frost; Robert A Kirken
Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity.
Molecular and cellular biology 2008;28(7):2271-82.
2008: Ayush Dagvadorj; Robert A Kirken; Benjamin Leiby; James Karras; Marja T Nevalainen
Transcription factor signal transducer and activator of transcription 5 promotes growth of human prostate cancer cells in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(5):1317-24.
2008: Jeremy A Ross; Zsuzsanna S Nagy; Robert A Kirken
The PHB1/2 phosphocomplex is required for mitochondrial homeostasis and survival of human T cells.
The Journal of biological chemistry 2008;283(8):4699-713.
2008: Shyh-Han Tan; Ayush Dagvadorj; Feng Shen; Lei Gu; Zhiyong Liao; Junaid Abdulghani; Ying Zhang; Edward P Gelmann; Tobias Zellweger; Zoran Culig; Tapio Visakorpi; Lukas Bubendorf; Robert A Kirken; James Karras; Marja T Nevalainen
Transcription factor Stat5 synergizes with androgen receptor in prostate cancer cells.
Cancer research 2008;68(1):236-48.
2007: Lynn M Neilson; Jianquong Zhu; Jianwu Xie; Maria Grazia Malabarba; Kazuhito Sakamoto; Kay-Uwe Wagner; Robert A Kirken; Hallgeir Rui
Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways.
Molecular endocrinology (Baltimore, Md.) 2007;21(9):2218-32.
2007: Jeremy A Ross; Zsuzsanna S Nagy; Hanyin Cheng; Stanislaw M Stepkowski; Robert A Kirken
Regulation of T cell homeostasis by JAKs and STATs.
Archivum immunologiae et therapiae experimentalis 2007;55(4):231-45.
2006: Zsuzsanna S Nagy; Hallgeir Rui; Stanislaw M Stepkowski; James Karras; Robert A Kirken
A preferential role for STAT5, not constitutively active STAT3, in promoting survival of a human lymphoid tumor.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5032-40.
2006: Lin Qiu; Raymond Lai; Quan Lin; Esther Lau; David M Thomazy; Daniel Calame; Richard J Ford; Larry W Kwak; Robert A Kirken; Hesham M Amin
Autocrine release of interleukin-9 promotes Jak3-dependent survival of ALK+ anaplastic large-cell lymphoma cells.
Blood 2006;108(7):2407-15.
2006: Stanislaw M Stepkowski; Robert A Kirken
Janus tyrosine kinases and signal transducers and activators of transcription regulate critical functions of T cells in allograft rejection and transplantation tolerance.
Transplantation 2006;82(3):295-303.
2006: Ye Zhang; Robert A Kirken; Lucrezia Furian; Slawa Janczewska; Xuimei Qu; Wayne W Hancock; Mouer Wang; Neelam Tejpal; Ronald H Kerman; Barry D Kahan; Stanislaw M Stepkowski
Allograft rejection requires STAT5a/b-regulated antiapoptotic activity in T cells but not B cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):128-37.
2005: Stanislaw M Stepkowski; Judy Kao; Mou-Er Wang; Neelam Tejpal; Hemangshu Podder; Lucrezia Furian; Jonathan R Dimmock; Amitabh Jha; Umashankar Das; Barry D Kahan; Robert A Kirken
The Mannich base NC1153 promotes long-term allograft survival and spares the recipient from multiple toxicities.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4236-46.
2005: Stanislaw M Stepkowski; Robert A Kirken
Unique advantage of Janus kinase 3 as a target for selective and nontoxic immunosuppression.
Expert review of clinical immunology 2005;1(3):307-10.
2004: Róbert Langer; Mouer Wang; Stanislaw M Stepkowski; Wayne W Hancock; Rongxiang Han; Ping Li; Lily Feng; Robert A Kirken; Kurt L Berens; Brian Dupre; Hemangshu Podder; Richard A F Dixon; Barry D Kahan
Selectin inhibitor bimosiamose prolongs survival of kidney allografts by reduction in intragraft production of cytokines and chemokines.
Journal of the American Society of Nephrology : JASN 2004;15(11):2893-901.
2004: Yuling Wang; Maria Grazia Malabarba; Zsuzsanna S Nagy; Robert A Kirken
Interleukin 4 regulates phosphorylation of serine 756 in the transactivation domain of Stat6. Roles for multiple phosphorylation sites and Stat6 function.
The Journal of biological chemistry 2004;279(24):25196-203.
2004: Zsuzsanna S Nagy; Jeremy Ross; Hanyin Cheng; Stanislaw M Stepkowski; Robert A Kirken
Regulation of lymphoid cell apoptosis by Jaks and Stats.
Critical reviews in immunology 2004;24(2):87-110.
2003: Fariba Behbod; Zsuzsanna S Nagy; Stanislaw M Stepkowski; James Karras; Charlene R Johnson; W David Jarvis; Robert A Kirken
Specific inhibition of Stat5a/b promotes apoptosis of IL-2-responsive primary and tumor-derived lymphoid cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):3919-27.
2003: Barry D Kahan; Robert A Kirken; Stanislaw M Stepkowski
New approaches to transplant immunosuppression.
Transplantation proceedings 2003;35(5):1621-3.
2003: Robert A Kirken; Y L Wang
Molecular actions of sirolimus: sirolimus and mTor.
Transplantation proceedings 2003;35(3 Suppl):227S-230S.
2002: Zsuzsanna S Nagy; Yuling Wang; Rebecca A Erwin-Cohen; János Aradi; Brett P Monia; Li Hua Wang; Stanislaw M Stepkowski; Hallgeir Rui; Robert A Kirken
Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.
Journal of leukocyte biology 2002;72(4):819-28.
2002: Stanislaw M Stepkowski; Robert A Kirken; Barton W Trawick; Min Wang; Neelam Tejpal; Mou-Er Wang; Ling Tian; James Clark; Barry D Kahan
Allochimeric class I MHC protein-induced tolerance by partial TCR engagement requires activation of both CTL4- and common gamma-chain-dependent cytokine signals.
Transplantation 2002;73(8):1227-35.
2002: Stanislaw M Stepkowski; Rebecca A Erwin-Cohen; Fariba Behbod; Mou-Er Wang; Xuimei Qu; Neelam Tejpal; Zsuzsanna S Nagy; Barry D Kahan; Robert A Kirken
Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin.
Blood 2002;99(2):680-9.
2001: Stanislaw M Stepkowski; Robert A Kirken; Zsuzsanna S Nagy; Barton W Trawick; Min Wang; Neelam Tejpal; Mou-Er Wang; Ling Tian; James Clark; Barry D Kahan
The role of Stat5 in the induction of regulatory T cells in transplantation tolerance.
Transplantation proceedings 2001;33(7-8):3835-6.
2001: Stanislaw M Stepkowski; Zsuzsanna S Nagy; Barry D Kahan; Robert A Kirken
The role of signals 1, 2, and 3 in induction of transplantation tolerance.
Transplantation proceedings 2001;33(7-8):3831-2.
2001: Stanislaw M Stepkowski; Zsuzsanna S Nagy; Mou-Er Wang; Fariba Behbod; Rebecca A Erwin-Cohen; Barry D Kahan; Robert A Kirken
PNU156804 inhibits Jak3 tyrosine kinase and rat heart allograft rejection.
Transplantation proceedings 2001;33(7-8):3272-3.
2001: Robert A Kirken
Targeting Jak3 for immune suppression and allograft acceptance.
Transplantation proceedings 2001;33(7-8):3268-70.
2001: H Yamashita; Marja T Nevalainen; J Xu; Matthew LeBaron; Kay-Uwe Wagner; RA Erwin; Jeffrey M Harmon; L Hennighausen; Robert A Kirken; Hallgeir Rui
Role of serine phosphorylation of Stat5a in prolactin-stimulated beta-casein gene expression.
Molecular and cellular endocrinology 2001;183(1-2):151-63.
2001: Xuimei Qu; Robert A Kirken; Ling Tian; Min Wang; C Frank Bennett; Stanislaw M Stepkowski
Selective inhibition of IL-2 gene expression by IL-2 antisense oligonucleotides blocks heart allograft rejection.
Transplantation 2001;72(5):915-23.
2001: Fariba Behbod; Rebecca A Erwin-Cohen; Mou-Er Wang; Barton W Trawick; Xuimei Qu; Regina Verani; Barry D Kahan; Stanislaw M Stepkowski; Robert A Kirken
Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(6):3724-32.
2001: Ling Tian; X Qu; Mou-Er Wang; Robert A Kirken; FC Bennett; Stanislaw M Stepkowski
Selective inhibition of IL-2 mRNA blocks allograft rejection by limiting T cell clonal expansion.
Transplantation proceedings 2001;33(1-2):330.
2001: M Wang; Robert A Kirken; Fariba Behbod; Rebecca A Erwin-Cohen; Stanislaw M Stepkowski; Barry D Kahan
Inhibition of Jak3 tyrosine kinase by PNU156804 blocks rat heart allograft rejection.
Transplantation proceedings 2001;33(1-2):201.
2001: Stanislaw M Stepkowski; Robert A Kirken; M Wang; J Yu; K Akioka; Barry D Kahan
Tolerance induction by alteration of T cell receptor (TCR) signaling using an allochimeric donor/recipient class I MHC protein.
Transplantation proceedings 2001;33(1-2):131.
2001: Robert A Kirken; Rebecca A Erwin-Cohen; Fariba Behbod; M Wang; Stanislaw M Stepkowski; Barry D Kahan
Tyrphostin AG490 selectively inhibits activation of the JAK3/STAT5/MAPK pathway and rejection of rat heart allografts.
Transplantation proceedings 2001;33(1-2):95.
2000: C H Yen; Y C Yang; S K Ruscetti; Robert A Kirken; R M Dai; C C Li
Involvement of the ubiquitin-proteasome pathway in the degradation of nontyrosine kinase-type cytokine receptors of IL-9, IL-2, and erythropoietin.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6372-80.
2000: Robert A Kirken; RA Erwin; L Wang; Yuling Wang; Hallgeir Rui; William L Farrar
Functional uncoupling of the Janus kinase 3-Stat5 pathway in malignant growth of human T cell leukemia virus type 1-transformed human T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):5097-104.
2000: Stanislaw M Stepkowski; Robert A Kirken
The role of IL-2 in allograft rejection--a lesson learned from experimental work.
Transplantation 2000;69(12):2480-2.
2000: LH Wang; Robert A Kirken; X Y Yang; RA Erwin; L DaSilva; Cheng-Rong Yu; William L Farrar
Selective disruption of interleukin 4 autocrine-regulated loop by a tyrosine kinase inhibitor restricts activity of T-helper 2 cells.
Blood 2000;95(12):3816-22.
2000: LH Wang; X Y Yang; Robert A Kirken; James Resau; William L Farrar
Targeted disruption of stat6 DNA binding activity by an oligonucleotide decoy blocks IL-4-driven T(H)2 cell response.
Blood 2000;95(4):1249-57.
1999: Robert A Kirken; RA Erwin; D Taub; William Murphy; Fariba Behbod; L Wang; Federica Pericle; William L Farrar
Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells.
Journal of leukocyte biology 1999;65(6):891-9.
1999: LH Wang; Robert A Kirken; RA Erwin; Cheng-Rong Yu; William L Farrar
JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(7):3897-904.
1998: H Yamashita; J Xu; RA Erwin; William L Farrar; Robert A Kirken; Hallgeir Rui
Differential control of the phosphorylation state of proline-juxtaposed serine residues Ser725 of Stat5a and Ser730 of Stat5b in prolactin-sensitive cells.
The Journal of biological chemistry 1998;273(46):30218-24.
1998: L DaSilva; Robert A Kirken; D D Taub; GA Evans; Roy J. Duhe; M A Bailey; William L Farrar
Molecular cloning of FKHRL1P2, a member of the developmentally regulated fork head domain transcription factor family.
Gene 1998;221(1):135-42.
1998: Cheng-Rong Yu; Robert A Kirken; Maria Grazia Malabarba; Howard A Young; John R Ortaldo
Differential regulation of the Janus kinase-STAT pathway and biologic function of IL-13 in primary human NK and T cells: a comparative study with IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(1):218-27.
1998: Robert A Kirken; GA Evans; Roy J. Duhe; L DaSilva; Maria Grazia Malabarba; RA Erwin; William L Farrar
Mechanisms of cytokine signal transduction: IL-2, IL-4 and prolactin as hematopoietin receptor models.
Veterinary immunology and immunopathology 1998;63(1-2):27-36.
1998: Roy J. Duhe; GA Evans; RA Erwin; Robert A Kirken; G W Cox; William L Farrar
Nitric oxide and thiol redox regulation of Janus kinase activity.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(1):126-31.
1998: Federica Pericle; Ligia A Pinto; S Hicks; Robert A Kirken; G Sconocchia; J Rusnak; Matthew J Dolan; Gene M Shearer; David M Segal
HIV-1 infection induces a selective reduction in STAT5 protein expression.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(1):28-31.
1997: Federica Pericle; Robert A Kirken; Vincenzo Bronte; G Sconocchia; L DaSilva; David M Segal
Immunocompromised tumor-bearing mice show a selective loss of STAT5a/b expression in T and B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):2580-5.
1997: Robert A Kirken; Maria Grazia Malabarba; J Xu; L DaSilva; RA Erwin; X Liu; L Hennighausen; Hallgeir Rui; William L Farrar
Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin/wortmannin-insensitive Stat5a/b serine kinase.
The Journal of biological chemistry 1997;272(24):15459-65.
1997: Robert A Kirken; Maria Grazia Malabarba; J Xu; X Liu; William L Farrar; L Hennighausen; A C Larner; Ph M Grimley; Hallgeir Rui
Prolactin stimulates serine/tyrosine phosphorylation and formation of heterocomplexes of multiple Stat5 isoforms in Nb2 lymphocytes.
The Journal of biological chemistry 1997;272(22):14098-103.
1996: Maria Grazia Malabarba; Hallgeir Rui; H H Deutsch; J Chung; F S Kalthoff; William L Farrar; Robert A Kirken
Interleukin-13 is a potent activator of JAK3 and STAT6 in cells expressing interleukin-2 receptor-gamma and interleukin-4 receptor-alpha.
The Biochemical journal 1996;319 ( Pt 3)():865-72.
1996: Federica Pericle; Robert A Kirken; P K Epling-Burnette; D K Blanchard; Julie Y Djeu
Direct killing of interleukin-2-transfected tumor cells by human neutrophils.
International journal of cancer. Journal international du cancer 1996;66(3):367-73.
1996: L DaSilva; Hallgeir Rui; RA Erwin; O M Zack Howard; Robert A Kirken; Maria Grazia Malabarba; R H Hackett; Andrew C Larner; William L Farrar
Prolactin recruits STAT1, STAT3 and STAT5 independent of conserved receptor tyrosines TYR402, TYR479, TYR515 and TYR580.
Molecular and cellular endocrinology 1996;117(2):131-40.
1995: Robert A Kirken; Hallgeir Rui; Maria Grazia Malabarba; O M Zack Howard; M Kawamura; John O'Shea; William L Farrar
Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor beta-chain.
Cytokine 1995;7(7):689-700.
1995: RA Erwin; Robert A Kirken; Maria Grazia Malabarba; William L Farrar; Hallgeir Rui
Prolactin activates Ras via signaling proteins SHC, growth factor receptor bound 2, and son of sevenless.
Endocrinology 1995;136(8):3512-8.
1995: Maria Grazia Malabarba; Robert A Kirken; Hallgeir Rui; K Koettnitz; M Kawamura; John O'Shea; F S Kalthoff; William L Farrar
Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha.
The Journal of biological chemistry 1995;270(16):9630-7.
1995: O M Zack Howard; Robert A Kirken; Gonzalo G Garcia; R H Hackett; William L Farrar
Structural domains of interleukin-2 receptor beta critical for signal transduction: kinase association and nuclear complex-formation.
The Biochemical journal 1995;306 ( Pt 1)():217-24.
1994: Hallgeir Rui; J J Lebrun; Robert A Kirken; P A Kelly; William L Farrar
JAK2 activation and cell proliferation induced by antibody-mediated prolactin receptor dimerization.
Endocrinology 1994;135(4):1299-306.
1994: Robert A Kirken; Hallgeir Rui; Maria Grazia Malabarba; William L Farrar
Identification of interleukin-2 receptor-associated tyrosine kinase p116 as novel leukocyte-specific Janus kinase.
The Journal of biological chemistry 1994;269(29):19136-41.
1994: L DaSilva; O M Zack Howard; Hallgeir Rui; Robert A Kirken; William L Farrar
Growth signaling and JAK2 association mediated by membrane-proximal cytoplasmic regions of prolactin receptors.
The Journal of biological chemistry 1994;269(28):18267-70.
1994: JA Johnston; M Kawamura; Robert A Kirken; Y Q Chen; T B Blake; K Shibuya; John R Ortaldo; Daniel W McVicar; John O'Shea
Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.
Nature 1994;370(6485):151-3.
1994: Hallgeir Rui; Robert A Kirken; William L Farrar
Activation of receptor-associated tyrosine kinase JAK2 by prolactin.
The Journal of biological chemistry 1994;269(7):5364-8.
1994: Robert A Kirken; Hallgeir Rui; O M Zack Howard; William L Farrar
Involvement of JAK-family tyrosine kinases in hematopoietin receptor signal transduction.
Progress in growth factor research 1994;5(2):195-211.
1993: Robert A Kirken; Hallgeir Rui; GA Evans; William L Farrar
Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit.
The Journal of biological chemistry 1993;268(30):22765-70.