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Ewen Kirkness

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Ewen F Kirkness; Roger S Lasken; Christian R Marshall; Stephen W Scherer; Rashel V Grindberg; Joyclyn Yee-Greenbaum; J Craig Venter
Sequencing of isolated sperm cells for direct haplotyping of a human genome.
Sarah M McDonald; Allison O McKell; Daniel C Payne; Christine M Rippinger; Asmik Akopov; James D Chappell; Kathryn M Edwards; Ewen F Kirkness; John K McAllen; John T Patton
Diversity and relationships of cocirculating modern human rotaviruses revealed using large-scale comparative genomics.
Athurva Gore; Zhe Li; Ho-Lim Fung; Jessica E Young; Suneet Agarwal; Jessica Antosiewicz-Bourget; Isabel Canto; Alessandra Giorgetti; Mason A Israel; Evangelos Kiskinis; Je-Hyuk Lee; Yuin-Han Loh; Philip D Manos; Nuria Montserrat; Athanasia D Panopoulos; Sergio Ruiz; Melissa L Wilbert; Junying Yu; Ewen F Kirkness; Juan Carlos Izpisua-Belmonte; Derrick J Rossi; James A Thomson; Kevin Eggan; George Q Daley; Lawrence S B Goldstein; Kun Zhang
Somatic coding mutations in human induced pluripotent stem cells.

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2013: Ewen F Kirkness; Roger S Lasken; Christian R Marshall; Stephen W Scherer; Rashel V Grindberg; Joyclyn Yee-Greenbaum; J Craig Venter
Sequencing of isolated sperm cells for direct haplotyping of a human genome.
Genome research 2013;23(5):826-32.
2012: Sarah M McDonald; Allison O McKell; Daniel C Payne; Christine M Rippinger; Asmik Akopov; James D Chappell; Kathryn M Edwards; Ewen F Kirkness; John K McAllen; John T Patton
Diversity and relationships of cocirculating modern human rotaviruses revealed using large-scale comparative genomics.
Journal of virology 2012;86(17):9148-62.
2011: Athurva Gore; Zhe Li; Ho-Lim Fung; Jessica E Young; Suneet Agarwal; Jessica Antosiewicz-Bourget; Isabel Canto; Alessandra Giorgetti; Mason A Israel; Evangelos Kiskinis; Je-Hyuk Lee; Yuin-Han Loh; Philip D Manos; Nuria Montserrat; Athanasia D Panopoulos; Sergio Ruiz; Melissa L Wilbert; Junying Yu; Ewen F Kirkness; Juan Carlos Izpisua-Belmonte; Derrick J Rossi; James A Thomson; Kevin Eggan; George Q Daley; Lawrence S B Goldstein; Kun Zhang
Somatic coding mutations in human induced pluripotent stem cells.
Nature 2011;471(7336):63-7.
2010: Abhirami Ratnakumar; Ewen F Kirkness; Brian P Dalrymple
Quality control of the sheep bacterial artificial chromosome library, CHORI-243.
BMC research notes 2010;3():334.
2010: Qi Zhao; Ewen F Kirkness; Otavia L Caballero; Pedro A Galante; Raphael B Parmigiani; Lee Edsall; Samantha Kuan; Zhen Ye; Samuel Levy; Ana Tereza R Vasconcelos; Bing Ren; Sandro J de Souza; Anamaria A Camargo; Andrew J G Simpson; Robert L Strausberg
Systematic detection of putative tumor suppressor genes through the combined use of exome and transcriptome sequencing.
Genome biology 2010;11(11):R114.
2010: Andy W Pang; Jeffrey R MacDonald; Dalila Pinto; John Wei; Muhammad A Rafiq; Donald F Conrad; Hansoo Park; Matthew E Hurles; Charles Lee; J Craig Venter; Ewen F Kirkness; Samuel Levy; Lars Feuk; Stephen W Scherer
Towards a comprehensive structural variation map of an individual human genome.
Genome biology 2010;11(5):R52.
2010: Pauline C Ng; Ewen F Kirkness
Whole genome sequencing.
Methods in molecular biology (Clifton, N.J.) 2010;628():215-26.
2009: Ewen F Kirkness
Targeted sequencing with microfluidics.
Nature biotechnology 2009;27(11):998-9.
2009: Jinchuan Xing; Yuhua Zhang; Kyudong Han; Abdel Halim Salem; Shurjo K Sen; Chad D Huff; Qiong Zhou; Ewen F Kirkness; Samuel Levy; Mark A Batzer; Lynn B Jorde
Mobile elements create structural variation: analysis of a complete human genome.
Genome research 2009;19(9):1516-26.
2009: Renfu Shao; Ewen F Kirkness; Stephen Barker
The single mitochondrial chromosome typical of animals has evolved into 18 minichromosomes in the human body louse, Pediculus humanus.
Genome research 2009;19(5):904-12.
2008: Christophe Hitte; Ewen F Kirkness; Elaine A Ostrander; Francis Galibert
Survey sequencing and radiation hybrid mapping to construct comparative maps.
Methods in molecular biology (Clifton, N.J.) 2008;422():65-77.
2007: Heidi G Parker; Anna V Kukekova; Dayna T Akey; Orly Goldstein; Ewen F Kirkness; Kathleen C Baysac; Dana S Mosher; Gustavo D Aguirre; Gregory M Acland; Elaine A Ostrander
Breed relationships facilitate fine-mapping studies: a 7.8-kb deletion cosegregates with Collie eye anomaly across multiple dog breeds.
Genome research 2007;17(11):1562-71.
2007: Byrappa Venkatesh; Ewen F Kirkness; Yong-Hwee Loh; Aaron L Halpern; Alison P Lee; Justin Johnson; Nidhi Dandona; Lakshmi D Viswanathan; Alice Tay; J Craig Venter; Robert L Strausberg; Sydney Brenner
Survey sequencing and comparative analysis of the elephant shark (Callorhinchus milii) genome.
PLoS biology 2007;5(4):e101.
2007: S R Hackett; S-W Jung; Ewen F Kirkness; J Cruickshank; Karen Lynn Vikstrom; N Sydney Moïse; Teresa M Gunn
Identification and characterization of canine microsatellite markers in cardiac genes.
Animal genetics 2007;38(1):89-91.
2007: Pascale Quignon; Laetitia Herbin; Edouard Cadieu; Ewen F Kirkness; Benoit Hédan; Dana S Mosher; Francis Galibert; Catherine André; Elaine A Ostrander; Christophe Hitte
Canine population structure: assessment and impact of intra-breed stratification on SNP-based association studies.
PloS one 2007;2(12):e1324.
2007: Brian P Dalrymple; Ewen F Kirkness; Mikhail Nefedov; Sean McWilliam; Abhirami Ratnakumar; Wes Barris; Shaying Zhao; Jyoti Shetty; Jillian F Maddox; Margaret O'Grady; Frank W Nicholas; Allan Crawford; Tim Smith; Pieter J de Jong; John McEwan; V Hutton Oddy; Noelle E Cockett
Using comparative genomics to reorder the human genome sequence into a virtual sheep genome.
Genome biology 2007;8(7):R152.
2007: Linda S Hunter; Duska J Sidjanin; Manuel Villagrasa Hijar; Jennifer L Johnson; Ewen F Kirkness; Gregory M Acland; Gustavo D Aguirre
Cloning and characterization of canine PAX6 and evaluation as a candidate gene in a canine model of aniridia.
Molecular vision 2007;13():431-42.
2006: Byrappa Venkatesh; Ewen F Kirkness; Yong-Hwee Loh; Aaron L Halpern; Alison P Lee; Justin Johnson; Nidhi Dandona; Lakshmi D Viswanathan; Alice Tay; J Craig Venter; Robert L Strausberg; Sydney Brenner
Ancient noncoding elements conserved in the human genome.
Science (New York, N.Y.) 2006;314(5807):1892.
2006: K S D Kothapalli; Ewen F Kirkness; R Vanwormer; Vicki N Meyers-Wallen
Exclusion of DMRT1 as a candidate gene for canine SRY-negative XX sex reversal.
Veterinary journal (London, England : 1997) 2006;171(3):559-61.
2006: Christian Natanaelsson; Mattias C R Oskarsson; Helen Angleby; Joakim Lundeberg; Ewen F Kirkness; Peter Savolainen
Dog Y chromosomal DNA sequence: identification, sequencing and SNP discovery.
BMC genetics 2006;7():45.
2006: Linda S Hunter; Duska J Sidjanin; Jennifer L Johnson; Barbara Zangerl; Francis Galibert; Catherine Andre; Ewen F Kirkness; Elijah Talamas; Gregory M Acland; Gustavo D Aguirre
Radiation hybrid mapping of cataract genes in the dog.
Molecular vision 2006;12():588-96.
2005: Rachael Thomas; Allyson Scott; Cordelia F Langford; Susan P Fosmire; Cristan M Jubala; Travis D Lorentzen; Christophe Hitte; Elinor K. Karlsson; Ewen F Kirkness; Elaine A Ostrander; Francis Galibert; Kerstin Lindblad-Toh; Jaime F Modiano; Matthew Breen
Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors.
Genome research 2005;15(12):1831-7.
2005: Wei Wang; Ewen F Kirkness
Short interspersed elements (SINEs) are a major source of canine genomic diversity.
Genome research 2005;15(12):1798-808.
2005: Qianchuan He; Mette Madsen; Adam Kilkenney; Brittany L Gregory; Erik I Christensen; Henrik Vorum; Peter Højrup; Alejandro A Schäffer; Ewen F Kirkness; Stephan M Tanner; Albert de La Chapelle; Urs Giger; Søren K Moestrup; John C Fyfe
Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B12) absorption in vivo.
Blood 2005;106(4):1447-53.
2005: Christophe Hitte; Jennifer Madeoy; Ewen F Kirkness; Catherine Priat; Travis D Lorentzen; Fabrice Senger; Dan Thomas; Thomas Derrien; Christina Ramirez; Carol Scott; Gwenaelle Evanno; Barbara Pullar; Edouard Cadieu; Vinay Oza; Kristelle Lourgant; David B Jaffe; Sandrine Tacher; Stéphane Dréano; Nadia Berkova; Catherine André; Panos Deloukas; Claire M Fraser-Liggett; Kerstin Lindblad-Toh; Elaine A Ostrander; Francis Galibert
Facilitating genome navigation: survey sequencing and dense radiation-hybrid gene mapping.
Nature reviews. Genetics 2005;6(8):643-8.
2005: S Pujar; K S D Kothapalli; Ewen F Kirkness; R H Van Wormer; Vicki N Meyers-Wallen
Exclusion of Lhx9 as a candidate gene for Sry-negative XX sex reversal in the American cocker spaniel model.
The Journal of heredity 2005;96(4):452-4.
2005: Petra Werner; Michael G Raducha; Ulana Prociuk; Elaine A Ostrander; Richard S Spielman; Ewen F Kirkness; Donald F Patterson; Paula S Henthorn
The keeshond defect in cardiac conotruncal development is oligogenic.
Human genetics 2005;116(5):368-77.
2005: K S D Kothapalli; Ewen F Kirkness; S Pujar; R Van Wormer; Vicki N Meyers-Wallen
Exclusion of candidate genes for canine SRY-negative XX sex reversal.
The Journal of heredity 2005;96(7):759-63.
2004: K S D Kothapalli; Ewen F Kirkness; S Pujar; Vicki N Meyers-Wallen
Exclusion of WT1 as a candidate gene for canine SRY-negative XX sex reversal.
Animal genetics 2004;35(6):466-7.
2004: Nathan B Sutter; Michael A Eberle; Heidi G Parker; Barbara J Pullar; Ewen F Kirkness; Leonid Kruglyak; Elaine A Ostrander
Extensive and breed-specific linkage disequilibrium in Canis familiaris.
Genome research 2004;14(12):2388-96.
2004: Matthew Breen; Christophe Hitte; Travis D Lorentzen; Rachael Thomas; Edouard Cadieu; Leah Sabacan; Allyson Scott; Gwenaelle Evanno; Heidi G Parker; Ewen F Kirkness; Ruth Hudson; Richard Guyon; Gregory G Mahairas; Boris Gelfenbeyn; Claire M Fraser-Liggett; Catherine André; Francis Galibert; Elaine A Ostrander
An integrated 4249 marker FISH/RH map of the canine genome.
BMC genomics 2004;5():65.
2004: Kenine Comstock; Frode Lingaas; Ewen F Kirkness; Christophe Hitte; Rachael Thomas; Matthew Breen; Francis Galibert; Elaine A Ostrander
A high-resolution comparative map of canine Chromosome 5q14.3-q33 constructed utilizing the 1.5x canine genome sequence.
Mammalian genome : official journal of the International Mammalian Genome Society 2004;15(7):544-51.
2004: Gregor Andelfinger; Christophe Hitte; Laura Etter; Richard Guyon; Guillaume Bourque; Glenn Tesler; Pavel A Pevzner; Ewen F Kirkness; Francis Galibert; D Woodrow Benson
Detailed four-way comparative mapping and gene order analysis of the canine ctvm locus reveals evolutionary chromosome rearrangements.
Genomics 2004;83(6):1053-62.
2004: John A Peters; Stephen P Kelley; James I Dunlop; Ewen F Kirkness; Tim G Hales; Jeremy J Lambert
The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance.
Biochemical Society transactions 2004;32(Pt3):547-52.
2004: Petra Werner; Michael G Raducha; D Shin; Elaine A Ostrander; Ewen F Kirkness; Donald F Patterson; Paula S Henthorn
Assignment of 10 canine genes to the canine linkage and comparative maps.
Animal genetics 2004;35(3):249-51.
2004: Anna V Kukekova; Lyudmila N Trut; Irina N Oskina; Anastasiya V Kharlamova; Svetlana G Shikhevich; Ewen F Kirkness; Gustavo D Aguirre; Gregory M Acland
A marker set for construction of a genetic map of the silver fox (Vulpes vulpes).
The Journal of heredity 2004;95(3):185-94.
2004: Emmanouil T Dermitzakis; Ewen F Kirkness; Scott Schwarz; Ewan Birney; Alexandre Reymond; Stylianos E Antonarakis
Comparison of human chromosome 21 conserved nongenic sequences (CNGs) with the mouse and dog genomes shows that their selective constraint is independent of their genic environment.
Genome research 2004;14(5):852-9.
2004: James W Kijas; Barbara Zangerl; Brian Miller; Jacque Nelson; Ewen F Kirkness; Gustavo D Aguirre; Gregory M Acland
Cloning of the canine ABCA4 gene and evaluation in canine cone-rod dystrophies and progressive retinal atrophies.
Molecular vision 2004;10():223-32.
2003: K S D Kothapalli; Ewen F Kirkness; L J Natale; Vicki N Meyers-Wallen
Exclusion of PISRT1 as a candidate locus for canine Sry-negative XX sex reversal.
Animal genetics 2003;34(6):467-9.
2003: Frode Lingaas; Kenine Comstock; Ewen F Kirkness; Anita Sørensen; Tone Aarskaug; Christophe Hitte; Michael L Nickerson; Lars Moe; Laura S Schmidt; Rachael Thomas; Matthew Breen; Francis Galibert; Berton Zbar; Elaine A Ostrander
A mutation in the canine BHD gene is associated with hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis in the German Shepherd dog.
Human molecular genetics 2003;12(23):3043-53.
2003: Emmanouil T Dermitzakis; Alexandre Reymond; Nathalie Scamuffa; Catherine Ucla; Ewen F Kirkness; Colette Rossier; Stylianos E Antonarakis
Evolutionary discrimination of mammalian conserved non-genic sequences (CNGs).
Science (New York, N.Y.) 2003;302(5647):1033-5.
2003: Qianchuan He; John C Fyfe; Alejandro A Schäffer; Adam Kilkenney; Petra Werner; Ewen F Kirkness; Paula S Henthorn
Canine Imerslund-Gräsbeck syndrome maps to a region orthologous to HSA14q.
Mammalian genome : official journal of the International Mammalian Genome Society 2003;14(11):758-64.
2003: Ewen F Kirkness; Vineet Bafna; Aaron L Halpern; Samuel Levy; Karin Remington; Douglas B Rusch; Arthur L Delcher; Mihai Pop; Wei Wang; Claire M Fraser-Liggett; J Craig Venter
The dog genome: survey sequencing and comparative analysis.
Science (New York, N.Y.) 2003;301(5641):1898-903.
2003: Gregor Andelfinger; Laura Etter; Macaira Dyment; Christophe Hitte; Francis Galibert; Ewen F Kirkness; D Woodrow Benson
Radiation hybrid mapping and genomic organization of canine TBX2 and TBX4.
Animal genetics 2003;34(4):307-9.
2003: Gary W Boyd; Anne I Doward; Ewen F Kirkness; Neil S Millar; Christopher N Connolly
Cell surface expression of 5-hydroxytryptamine type 3 receptors is controlled by an endoplasmic reticulum retention signal.
The Journal of biological chemistry 2003;278(30):27681-7.
2003: Stephen P Kelley; James I Dunlop; Ewen F Kirkness; Jeremy J Lambert; John A Peters
A cytoplasmic region determines single-channel conductance in 5-HT3 receptors.
Nature 2003;424(6946):321-4.
2003: Jennifer K Lowe; Anna V Kukekova; Ewen F Kirkness; Mariela C Langlois; Gustavo D Aguirre; Gregory M Acland; Elaine A Ostrander
Linkage mapping of the primary disease locus for collie eye anomaly.
Genomics 2003;82(1):86-95.
2003: A Stewart; Paul Davies; Ewen F Kirkness; P Safa; Tim G Hales
Introduction of the 5-HT3B subunit alters the functional properties of 5-HT3 receptors native to neuroblastoma cells.
Neuropharmacology 2003;44(2):214-23.
2003: Paul Davies; Wei Wang; Tim G Hales; Ewen F Kirkness
A novel class of ligand-gated ion channel is activated by Zn2+.
The Journal of biological chemistry 2003;278(2):712-7.
2003: Richard Guyon; Ewen F Kirkness; Travis D Lorentzen; Christophe Hitte; Kenine Comstock; Pascale Quignon; Thomas Derrien; Catherine André; Claire M Fraser-Liggett; Francis Galibert; Elaine A Ostrander
Building comparative maps using 1.5x sequence coverage: human chromosome 1p and the canine genome.
Cold Spring Harbor symposia on quantitative biology 2003;68():171-7.
2003: Pascale Quignon; Ewen F Kirkness; Edouard Cadieu; Nizar Touleimat; Richard Guyon; Corinne Renier; Christophe Hitte; Catherine André; Claire M Fraser-Liggett; Francis Galibert
Comparison of the canine and human olfactory receptor gene repertoires.
Genome biology 2003;4(12):R80.
2002: Paul Davies; M R McCartney; W Wang; Tim G Hales; Ewen F Kirkness
Alternative transcripts of the GABA(A) receptor epsilon subunit in human and rat.
Neuropharmacology 2002;43(4):467-75.
2001: Paul Davies; Ewen F Kirkness; Tim G Hales
Evidence for the formation of functionally distinct alphabetagammaepsilon GABA(A) receptors.
The Journal of physiology 2001;537(Pt 1):101-13.
2000: MC Hanna; Paul Davies; Tim G Hales; Ewen F Kirkness
Evidence for expression of heteromeric serotonin 5-HT(3) receptors in rodents.
Journal of neurochemistry 2000;75(1):240-7.
1999: Paul Davies; Marco Pistis; MC Hanna; John A Peters; Jeremy J Lambert; Tim G Hales; Ewen F Kirkness
The 5-HT3B subunit is a major determinant of serotonin-receptor function.
Nature 1999;397(6717):359-63.
1997: MC Hanna; J T Platts; Ewen F Kirkness
Identification of a gene within the tandem array of red and green color pigment genes.
Genomics 1997;43(3):384-6.
1997: E Hedblom; Ewen F Kirkness
A novel class of GABAA receptor subunit in tissues of the reproductive system.
The Journal of biological chemistry 1997;272(24):15346-50.
1997: MC Hanna; A J Turner; Ewen F Kirkness
Human pyridoxal kinase. cDNA cloning, expression, and modulation by ligands of the benzodiazepine receptor.
The Journal of biological chemistry 1997;272(16):10756-60.
1997: Paul Davies; Ewen F Kirkness; Tim G Hales
Modulation by general anaesthetics of rat GABAA receptors comprised of alpha 1 beta 3 and beta 3 subunits expressed in human embryonic kidney 293 cells.
British journal of pharmacology 1997;120(5):899-909.
1997: Paul Davies; MC Hanna; Tim G Hales; Ewen F Kirkness
Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit.
Nature 1997;385(6619):820-3.
1996: D Sinnett; E Woolf; W Xie; K Glatt; Ewen F Kirkness; T O Nielsen; Maria Zannis-Hadjopoulos; Gerald B Price; Marc Lalande
Identification of a putative DNA replication origin in the gamma-aminobutyric acid receptor subunit beta3 and alpha5 gene cluster on human chromosome 15q11-q13, a region associated with parental imprinting and allele-specific replication timing.
Gene 1996;173(2):171-7.
1996: Carol Bult; Owen R White; Gary J Olsen; L Zhou; Robert D Fleischmann; Granger Sutton; J A Blake; L M FitzGerald; R A Clayton; J D Gocayne; A R Kerlavage; B A Dougherty; J F Tomb; Mark D Adams; C I Reich; Ross Overbeek; Ewen F Kirkness; K G Weinstock; J M Merrick; A Glodek; J L Scott; N S Geoghagen; J Craig Venter
Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii.
Science (New York, N.Y.) 1996;273(5278):1058-73.
1996: Ewen F Kirkness
Assessment of human gene diversity and expression patterns using expressed sequence tags.
Essays in biochemistry 1996;31():1-9.
1995: Mark D Adams; A R Kerlavage; Robert D Fleischmann; R A Fuldner; Carol Bult; N H Lee; Ewen F Kirkness; K G Weinstock; J D Gocayne; Owen R White
Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.
Nature 1995;377(6547 Suppl):3-174.
1995: N H Lee; K G Weinstock; Ewen F Kirkness; J A Earle-Hughes; R A Fuldner; S Marmaros; A Glodek; J D Gocayne; Mark D Adams; A R Kerlavage
Comparative expressed-sequence-tag analysis of differential gene expression profiles in PC-12 cells before and after nerve growth factor treatment.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8303-7.
1995: Robert D Fleischmann; Mark D Adams; Owen R White; R A Clayton; Ewen F Kirkness; A R Kerlavage; Carol Bult; J F Tomb; B A Dougherty; J M Merrick
Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.
Science (New York, N.Y.) 1995;269(5223):496-512.
1994: K G Weinstock; Ewen F Kirkness; N H Lee; J A Earle-Hughes; J Craig Venter
cDNA sequencing: a means of understanding cellular physiology.
Current opinion in biotechnology 1994;5(6):599-603.
1991: Joseph Wagstaff; JH Knoll; J Fleming; Ewen F Kirkness; A Martin-Gallardo; F Greenberg; J M Graham; J Menninger; D Ward; J Craig Venter
Localization of the gene encoding the GABAA receptor beta 3 subunit to the Angelman/Prader-Willi region of human chromosome 15.
American journal of human genetics 1991;49(2):330-7.
1991: Ewen F Kirkness; J W Kusiak; J T Fleming; J Menninger; J D Gocayne; David C Ward; J Craig Venter
Isolation, characterization, and localization of human genomic DNA encoding the beta 1 subunit of the GABAA receptor (GABRB1).
Genomics 1991;10(4):985-95.
1989: Ewen F Kirkness; J Craig Venter
Anti-receptor antibodies.
Current opinion in immunology 1989;1(4):679-83.
1988: John A Peters; Ewen F Kirkness; H Callachan; Jeremy J Lambert; A J Turner
Modulation of the GABAA receptor by depressant barbiturates and pregnane steroids.
British journal of pharmacology 1988;94(4):1257-69.