FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Tadamitsu Kishimoto

Research Profile

Chemicals & Drugs

Living Beings

Mouse

Physiology

Concepts & Ideas

Molecular Sequence Data

Anatomy

Genes & Molecular Sequences

Amino Acid Sequences

Co-author Network

Publications

TOP 3
Shumpei Yokota; Tomoyuki Imagawa; Naomi Iwata; Takako Miyamae; Mari Miyoshi; Masaaki Mori; Takuji Murata; Norihiro Nishimoto; Syuji Takei; Minako Tomiita; Hiroaki Umebayashi; Tadamitsu Kishimoto
Long-term treatment of systemic juvenile idiopathic arthritis with tocilizumab: results of an open-label extension study in Japan.
Kota Iwahori; Ichiro Kawase; Tadamitsu Kishimoto; Hiroyuki Mizuguchi; Shintaro Nomura; Barry Ripley; Satoshi Serada; Kazuki Shimada; Tsuyoshi Takahashi; Minoru Fujimoto; Tetsuji Naka
SOCS-1 gene delivery cooperates with cisplatin plus pemetrexed to exhibit preclinical antitumor activity against malignant pleural mesothelioma.
Shumpei Yokota; Toshio Tanaka; Tadamitsu Kishimoto
Efficacy, safety and tolerability of tocilizumab in patients with systemic juvenile idiopathic arthritis.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Tadamitsu Kishimoto (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Shumpei Yokota; Tomoyuki Imagawa; Naomi Iwata; Takako Miyamae; Mari Miyoshi; Masaaki Mori; Takuji Murata; Norihiro Nishimoto; Syuji Takei; Minako Tomiita; Hiroaki Umebayashi; Tadamitsu Kishimoto
Long-term treatment of systemic juvenile idiopathic arthritis with tocilizumab: results of an open-label extension study in Japan.
Annals of the rheumatic diseases 2013;72(4):627-8.
2013: Kota Iwahori; Ichiro Kawase; Tadamitsu Kishimoto; Hiroyuki Mizuguchi; Shintaro Nomura; Barry Ripley; Satoshi Serada; Kazuki Shimada; Tsuyoshi Takahashi; Minoru Fujimoto; Tetsuji Naka
SOCS-1 gene delivery cooperates with cisplatin plus pemetrexed to exhibit preclinical antitumor activity against malignant pleural mesothelioma.
International journal of cancer. Journal international du cancer 2013;132(2):459-71.
2012: Shumpei Yokota; Toshio Tanaka; Tadamitsu Kishimoto
Efficacy, safety and tolerability of tocilizumab in patients with systemic juvenile idiopathic arthritis.
Therapeutic advances in musculoskeletal disease 2012;4(6):387-97.
2012: Toru Hirano; Satoshi Hohki; Tadamitsu Kishimoto; Atsushi Kumanogoh; Michiko Narazaki; Atsushi Ogata; Nobuyuki Ohguro; Yoshihito Shima; Keisuke Hagihara; Kazuyuki Yoshizaki; Toshio Tanaka
A case of Behçet's disease treated with a humanized anti-interleukin-6 receptor antibody, tocilizumab.
Modern rheumatology / the Japan Rheumatism Association 2012;22(2):298-302.
2012: Tomiharu Niida; Kiyoshi Takeda; Takeshi Adachi; Norio Ishigami; Kikuo Isoda; Tadamitsu Kishimoto; Manabu Kitagaki; Osamu Matsubara; Fumitaka Ohsuzu
IκBNS regulates interleukin-6 production and inhibits neointimal formation after vascular injury in mice.
Cardiovascular research 2012;93(2):371-9.
2012: Tomoyuki Imagawa; Hiroyuki Imanaka; Naomi Iwata; Takako Miyamae; Mari Miyoshi; Masaaki Mori; Takuji Murata; Yasuhito Nerome; Norihiro Nishimoto; Syuji Takei; Shumpei Yokota; Tadamitsu Kishimoto
Safety and efficacy of tocilizumab, an anti-IL-6-receptor monoclonal antibody, in patients with polyarticular-course juvenile idiopathic arthritis.
Modern rheumatology / the Japan Rheumatism Association 2012;22(1):109-15.
2012: Toshio Tanaka; Tadamitsu Kishimoto
Targeting interleukin-6: all the way to treat autoimmune and inflammatory diseases.
International journal of biological sciences 2012;8(9):1227-36.
2011: Toshio Tanaka; Michiko Narazaki; Tadamitsu Kishimoto
Anti-interleukin-6 receptor antibody, tocilizumab, for the treatment of autoimmune diseases.
FEBS letters 2011;585(23):3699-709.
2011: Kazuya Masuda; Tomotaka Murotani; Taisuke Nakahama; Nam-Trung Nguyen; Yuichi Otoyo; Atsushi Yamatodani; Ichino Chinen; Hamza Hanieh; Akihiro Kimura; Tadamitsu Kishimoto
Aryl hydrocarbon receptor negatively regulates LPS-induced IL-6 production through suppression of histamine production in macrophages.
International immunology 2011;23(10):637-45.
2011: Tomomi Yamashita; Minoru Fujimoto; Akiko Hayama; Tomohiko Iwakura; Yasukatsu Izumi; Haruyo Kawaguchi; Tadamitsu Kishimoto; Issei Komuro; Makiko Maeda; Kazuki Matsui; Tetsuji Naka; Hiroyuki Nakayama; Masanori Obana; Yoshiyuki Ohsugi; Yasushi Fujio
IL-6-mediated Th17 differentiation through RORγt is essential for the initiation of experimental autoimmune myocarditis.
Cardiovascular research 2011;91(4):640-8.
2011: Taisuke Nakahama; Nam-Trung Nguyen; Keiko Nohara; Ichino Chinen; Yoshiaki Fujii-Kuriyama; Hamza Hanieh; Akihiro Kimura; Tadamitsu Kishimoto
Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(34):14222-7.
2011: Kota Iwahori; Ichiro Kawase; Tadamitsu Kishimoto; Chun Man Lee; Hiroyuki Mizuguchi; Shintaro Nomura; Meinoshin Okumura; Tadashi Osaki; Barry Ripley; Satoshi Serada; Tsuyoshi Takahashi; Minoru Fujimoto; Tetsuji Naka
Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma.
International journal of cancer. Journal international du cancer 2011;129(4):1005-17.
2011: Yoshihito Shima; Tetsuya Tomita; Taeko Ishii; Tadamitsu Kishimoto; Yuichi Maeda; Atsuyoshi Morishima; Atsushi Ogata; Toshio Tanaka
Tocilizumab, a humanized anti-interleukin-6 receptor antibody, ameliorated clinical symptoms and MRI findings of a patient with ankylosing spondylitis.
Modern rheumatology / the Japan Rheumatism Association 2011;21(4):436-9.
2011: Sumiyuki Nishida; Atsushi Ogata; Yoshihiro Oka; Yoshihito Shima; Keisuke Hagihara; Toru Hirano; Yoshihiro Hishitani; Taeko Ishii; Hirokazu Kashiwagi; Mari Kawai; Tomio Kawasaki; Tadamitsu Kishimoto; Atsuyoshi Morishima; Michiko Narazaki; Toshio Tanaka
Successful treatment of acquired hemophilia A, complicated by chronic GVHD, with tocilizumab.
Modern rheumatology / the Japan Rheumatism Association 2011;21(4):420-2.
2011: Michiko Narazaki; Atsushi Ogata; Yoshihito Shima; Keisuke Hagihara; Tadamitsu Kishimoto; Toshio Tanaka
Therapeutic effect of tocilizumab on two patients with polymyositis.
Rheumatology (Oxford, England) 2011;50(7):1344-6.
2011: Hiroshi Haruta; Nobuyuki Ohguro; Minoru Fujimoto; Satoshi Hohki; Fumitaka Terabe; Satoshi Serada; Shintaro Nomura; Kohji Nishida; Tadamitsu Kishimoto; Tetsuji Naka
Blockade of interleukin-6 signaling suppresses not only th17 but also interphotoreceptor retinoid binding protein-specific Th1 by promoting regulatory T cells in experimental autoimmune uveoretinitis.
Investigative ophthalmology & visual science 2011;52(6):3264-71.
2011: Akihiro Kimura; Tadamitsu Kishimoto
Th17 cells in inflammation.
International immunopharmacology 2011;11(3):319-22.
2011: Fumitaka Terabe; Minoru Fujimoto; Satoshi Serada; Shinichiro Shinzaki; Hideki Iijima; Masahiko Tsujii; Norio Hayashi; Shintaro Nomura; Hirohisa Kawahata; Myoung Ho Jang; Masayuki Miyasaka; Masahiko Mihara; Yoshiyuki Ohsugi; Tadamitsu Kishimoto; Tetsuji Naka
Comparative analysis of the effects of anti-IL-6 receptor mAb and anti-TNF mAb treatment on CD4+ T-cell responses in murine colitis.
Inflammatory bowel diseases 2011;17(2):491-502.
2011: Masaji Okada; Yoko Kita; Noriko Kanamaru; Satomi Hashimoto; Yasushi Uchiyama; Masahiko Mihara; Yoshikazu Inoue; Yoshiyuki Ohsugi; Tadamitsu Kishimoto; Mitsunori Sakatani
Anti-IL-6 receptor antibody causes less promotion of tuberculosis infection than anti-TNF-α antibody in mice.
Clinical & developmental immunology 2011;2011():404929.
2011: Minoru Fujimoto; Mayumi Nakano; Fumitaka Terabe; Hirohisa Kawahata; Tomoharu Ohkawara; Yongmei Han; Barry Ripley; Satoshi Serada; Teppei Nishikawa; Akihiro Kimura; Shintaro Nomura; Tadamitsu Kishimoto; Tetsuji Naka
The influence of excessive IL-6 production in vivo on the development and function of Foxp3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(1):32-40.
2010: Yoshihito Shima; Yusuke Kuwahara; Hiroyuki Murota; Shun Kitaba; Mari Kawai; Toru Hirano; Junsuke Arimitsu; Michiko Narazaki; Keisuke Hagihara; Atsushi Ogata; Ichiro Katayama; Ichiro Kawase; Tadamitsu Kishimoto; Toshio Tanaka
The skin of patients with systemic sclerosis softened during the treatment with anti-IL-6 receptor antibody tocilizumab.
Rheumatology (Oxford, England) 2010;49(12):2408-12.
2010: Nam-Trung Nguyen; Akihiro Kimura; Taisuke Nakahama; Ichino Chinen; Kazuya Masuda; Keiko Nohara; Yoshiaki Fujii-Kuriyama; Tadamitsu Kishimoto
Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(46):19961-6.
2010: Shumpei Yokota; Tadamitsu Kishimoto
Tocilizumab: molecular intervention therapy in children with systemic juvenile idiopathic arthritis.
Expert review of clinical immunology 2010;6(5):735-43.
2010: Satoshi Hohki; Nobuyuki Ohguro; Hiroshi Haruta; Kei Nakai; Fumitaka Terabe; Satoshi Serada; Minoru Fujimoto; Shintaro Nomura; Hirohisa Kawahata; Tadamitsu Kishimoto; Tetsuji Naka
Blockade of interleukin-6 signaling suppresses experimental autoimmune uveoretinitis by the inhibition of inflammatory Th17 responses.
Experimental eye research 2010;91(2):162-70.
2010: Akihiro Kimura; Tadamitsu Kishimoto
IL-6: regulator of Treg/Th17 balance.
European journal of immunology 2010;40(7):1830-5.
2010: Keisuke Hagihara; Ichiro Kawase; Toshio Tanaka; Tadamitsu Kishimoto
Tocilizumab ameliorates clinical symptoms in polymyalgia rheumatica.
The Journal of rheumatology 2010;37(5):1075-6.
2010: Tadamitsu Kishimoto
IL-6: from its discovery to clinical applications.
International immunology 2010;22(5):347-52.
2010: Barry J M Ripley; Minoru Fujimoto; Satoshi Serada; Tomoharu Ohkawara; Teppei Nishikawa; Fumitaka Terabe; Yuko Matsukawa; Anastasis Stephanou; Richard A Knight; David A Isenberg; David S Latchman; Tadamitsu Kishimoto; Tetsuji Naka
Green tea polyphenol epigallocatechin gallate inhibits cell signaling by inducing SOCS1 gene expression.
International immunology 2010;22(5):359-66.
2010: Toshio Tanaka; Keisuke Hagihara; Yoshihito Shima; masashi narazaki; Atsushi Ogata; Ichiro Kawase; Tadamitsu Kishimoto
Treatment of a patient with remitting seronegative, symmetrical synovitis with pitting oedema with a humanized anti-interleukin-6 receptor antibody, tocilizumab.
Rheumatology (Oxford, England) 2010;49(4):824-6.
2010: Atsushi Ogata; Masahide Mori; Shoji Hashimoto; Yukihiro Yano; Takeya Fujikawa; Mari Kawai; Yusuke Kuwahara; Toru Hirano; Junsuke Arimitsu; Keisuke Hagihara; Yoshihito Shima; masashi narazaki; Souichirou Yokota; Tadamitsu Kishimoto; Ichiro Kawase; Toshio Tanaka
Minimal influence of tocilizumab on IFN-gamma synthesis by tuberculosis antigens.
Modern rheumatology / the Japan Rheumatism Association 2010;20(2):130-3.
2010: Satoshi Serada; Minoru Fujimoto; Atsushi Ogata; Fumitaka Terabe; Toru Hirano; Hideki Iijima; Shinichiro Shinzaki; Teppei Nishikawa; Tomoharu Ohkawara; Kota Iwahori; Nobuyuki Ohguro; Tadamitsu Kishimoto; Tetsuji Naka
iTRAQ-based proteomic identification of leucine-rich alpha-2 glycoprotein as a novel inflammatory biomarker in autoimmune diseases.
Annals of the rheumatic diseases 2010;69(4):770-4.
2009: Toshio Tanaka; Yusuke Kuwahara; Yoshihito Shima; Toru Hirano; Mari Kawai; Masako Ogawa; Junsuke Arimitsu; Keisuke Hagihara; Michiko Narazaki; Atsushi Ogata; Ichiro Kawase; Tadamitsu Kishimoto
Successful treatment of reactive arthritis with a humanized anti-interleukin-6 receptor antibody, tocilizumab.
Arthritis and rheumatism 2009;61(12):1762-4.
2009: Pamina Pflegerl; Paul Vesely; Brigitte Hantusch; Michaela Schlederer; Rainer Zenz; Elke Janig; Günter Steiner; Arabella Meixner; peter petzelbauer; Peter Wolf; Afschin Soleiman; Gerda Egger; Richard Moriggl; Tadamitsu Kishimoto; Erwin F Wagner; Lukas Kenner
Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(48):20423-8.
2009: Akihiro Kimura; Tetsuji Naka; Taisuke Nakahama; Ichino Chinen; Kazuya Masuda; Keiko Nohara; Yoshiaki Fujii-Kuriyama; Tadamitsu Kishimoto
Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses.
The Journal of experimental medicine 2009;206(9):2027-35.
2009: Masahiko Mihara; Yoshiyuki Ohsugi; Tadamitsu Kishimoto
Evidence for the role of Th17 cell inhibition in the prevention of autoimmune diseases by anti-interluekin-6 receptor antibody.
BioFactors (Oxford, England) 2009;35(1):47-51.
2009: Norihiro Nishimoto; Nobuyuki Miyasaka; Kazuhiko Yamamoto; Shinichi Kawai; Tsutomu Takeuchi; Junichi Azuma; Tadamitsu Kishimoto
Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy.
Modern rheumatology / the Japan Rheumatism Association 2009;19(1):12-9.
2008: Minoru Fujimoto; Satoshi Serada; Masahiko Mihara; Yasushi Uchiyama; Hiroto Yoshida; Nobuo Koike; Yoshiyuki Ohsugi; Teppei Nishikawa; Barry Ripley; Akihiro Kimura; Tadamitsu Kishimoto; Tetsuji Naka
Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses.
Arthritis and rheumatism 2008;58(12):3710-9.
2008: Akihiro Kimura; Tetsuji Naka; Keiko Nohara; Yoshiaki Fujii-Kuriyama; Tadamitsu Kishimoto
Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(28):9721-6.
2008: Cheng-Rong Yu; Rashid M Mahdi; Xuebin Liu; Allen Zhang; Tetsuji Naka; Tadamitsu Kishimoto; Charles E Egwuagu
SOCS1 regulates CCR7 expression and migration of CD4+ T cells into peripheral tissues.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):1190-8.
2008: Satoshi Serada; Minoru Fujimoto; Masahiko Mihara; Nobuo Koike; Yoshiyuki Ohsugi; Shintaro Nomura; Hiroto Yoshida; Teppei Nishikawa; Fumitaka Terabe; Tomoharu Ohkawara; Tsuyoshi Takahashi; Barry Ripley; Akihiro Kimura; Tadamitsu Kishimoto; Tetsuji Naka
IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(26):9041-6.
2008: Jiro Horino; Minoru Fujimoto; Fumitaka Terabe; Satoshi Serada; Tsuyoshi Takahashi; Yoshihito Soma; Kentaro Tanaka; Takatoshi Chinen; Akihiko Yoshimura; Shintaro Nomura; Ichiro Kawase; Norio Hayashi; Tadamitsu Kishimoto; Tetsuji Naka
Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice.
International immunology 2008;20(6):753-62.
2008: Yoshiyuki Ohsugi; Tadamitsu Kishimoto
The recombinant humanized anti-IL-6 receptor antibody tocilizumab, an innovative drug for the treatment of rheumatoid arthritis.
Expert opinion on biological therapy 2008;8(5):669-81.
2008: Shumpei Yokota; Tomoyuki Imagawa; Masaaki Mori; Takako Miyamae; Yukoh Aihara; Syuji Takei; Naomi Iwata; Hiroaki Umebayashi; Takuji Murata; Mari Miyoshi; Minako Tomiita; Norihiro Nishimoto; Tadamitsu Kishimoto
Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial.
Lancet 2008;371(9617):998-1006.
2008: Keiichi Iwanami; Isao Matsumoto; Yoko Tanaka-Watanabe; Asuka Inoue; Masahiko Mihara; Yoshiyuki Ohsugi; Mizuko Mamura; Daisuke Goto; Satoshi Ito; Akito Tsutsumi; Tadamitsu Kishimoto; Takayuki Sumida
Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase.
Arthritis and rheumatism 2008;58(3):754-63.
2008: Ekihiro Seki; Yuichi Kondo; Yuji Iimuro; Tetsuji Naka; Gakuhei Son; Tadamitsu Kishimoto; Jiro Fujimoto; Hiroko Tsutsui; Kenji Nakanishi
Demonstration of cooperative contribution of MET- and EGFR-mediated STAT3 phosphorylation to liver regeneration by exogenous suppressor of cytokine signalings.
Journal of hepatology 2008;48(2):237-45.
2007: Norihiro Nishimoto; Jun Hashimoto; Nobuyuki Miyasaka; Kazuhiko Yamamoto; Shinichi Kawai; Tsutomu Takeuchi; Norikazu Murata; Désirée van der Heijde; Tadamitsu Kishimoto
Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab.
Annals of the rheumatic diseases 2007;66(9):1162-7.
2007: Akihiro Kimura; Tetsuji Naka; Tadamitsu Kishimoto
IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(29):12099-104.
2007: Susetta Finotto; Tatjana Eigenbrod; Roman Karwot; Ildiko Boross; Aysefa Doganci; Hiroaki Ito; Norihiro Nishimoto; Kazuyuki Yoshizaki; Tadamitsu Kishimoto; Stefan Rose-John; Peter R Galle; Markus F Neurath
Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells.
International immunology 2007;19(6):685-93.
2007: Ryusuke Kimura; Makiko Maeda; Atsushi Arita; Yuichi Oshima; Masanori Obana; Takashi Ito; Yasuhiro Yamamoto; Tomomi Mohri; Tadamitsu Kishimoto; Ichiro Kawase; Yasushi Fujio; Junichi Azuma
Identification of cardiac myocytes as the target of interleukin 11, a cardioprotective cytokine.
Cytokine 2007;38(2):107-15.
2007: Yukiko Kanatani; Isao Usui; Ken Ishizuka; Agussalim Bukhari; Shiho Fujisaka; Masaharu Urakaze; Tetsuro Haruta; Tadamitsu Kishimoto; Tetsuji Naka; Masashi Kobayashi
Effects of pioglitazone on suppressor of cytokine signaling 3 expression: potential mechanisms for its effects on insulin sensitivity and adiponectin expression.
Diabetes 2007;56(3):795-803.
2006: Norihiro Nishimoto; Tadamitsu Kishimoto
Interleukin 6: from bench to bedside.
Nature clinical practice. Rheumatology 2006;2(11):619-26.
2006: Rainer H Straub; Peter Härle; Seizo Yamana; Takemasa Matsuda; Kiyoshi Takasugi; Tadamitsu Kishimoto; Norihiro Nishimoto
Anti-interleukin-6 receptor antibody therapy favors adrenal androgen secretion in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study.
Arthritis and rheumatism 2006;54(6):1778-85.
2006: Xinshou Ouyang; Minoru Fujimoto; Reiko Nakagawa; Satoshi Serada; Toshio Tanaka; Shintaro Nomura; Ichiro Kawase; Tadamitsu Kishimoto; Tetsuji Naka
SOCS-2 interferes with myotube formation and potentiates osteoblast differentiation through upregulation of JunB in C2C12 cells.
Journal of cellular physiology 2006;207(2):428-36.
2006: Tomomi Mohri; Yasushi Fujio; Makiko Maeda; Takashi Ito; Tomohiko Iwakura; Yuichi Oshima; Yoriko Uozumi; Masashi Segawa; Hiroshi Yamamoto; Tadamitsu Kishimoto; Junichi Azuma
Leukemia inhibitory factor induces endothelial differentiation in cardiac stem cells.
The Journal of biological chemistry 2006;281(10):6442-7.
2006: Tadamitsu Kishimoto
Interleukin-6: discovery of a pleiotropic cytokine.
Arthritis research & therapy 2006;8 Suppl 2():S2.
2005: Akihiro Kimura; Tetsuji Naka; Tatsushi Muta; Osamu Takeuchi; Shizuo Akira; Ichiro Kawase; Tadamitsu Kishimoto
Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(47):17089-94.
2005: Norihiro Nishimoto; Yuzuru Kanakura; Katsuyuki Aozasa; Takeshi Johkoh; Minoru Nakamura; Shuji Nakano; Nobuaki Nakano; Yasuo Ikeda; Takeshi Sasaki; Kiyoshi Nishioka; Masamichi Hara; Hirokuni Taguchi; Yukihiko Kimura; Yoshiro Kato; Hideki Asaoku; Shunichi Kumagai; Fumio Kodama; Hideko Nakahara; Keisuke Hagihara; Kazuyuki Yoshizaki; Tadamitsu Kishimoto
Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease.
Blood 2005;106(8):2627-32.
2005: Tadamitsu Kishimoto
IL-6: from laboratory to bedside.
Clinical reviews in allergy & immunology 2005;28(3):177-86.
2005: Kanji Sugimoto; Norihiro Nishimoto; Tadamitsu Kishimoto; Kazuyuki Yoshizaki; Tsunehiko Nishimura
Imaging of lesions in a murine rheumatoid arthritis model with a humanized anti-interleukin-6 receptor antibody.
Annals of nuclear medicine 2005;19(4):261-6.
2005: Yasuyuki Kai; Ichiro Takahashi; Hiromichi Ishikawa; Takachika Hiroi; Tsunekazu Mizushima; Chu Matsuda; Daisuke Kishi; Hiromasa Hamada; Hiroshi Tamagawa; Toshinori Ito; Kazuyuki Yoshizaki; Tadamitsu Kishimoto; Hikaru Matsuda; Hiroshi Kiyono
Colitis in mice lacking the common cytokine receptor gamma chain is mediated by IL-6-producing CD4+ T cells.
Gastroenterology 2005;128(4):922-34.
2005: Makiko Inaba; Hiroshi Saito; Minoru Fujimoto; Satoru Sumitani; Tomoharu Ohkawara; Toshio Tanaka; Haruhiko Kouhara; Soji Kasayama; Ichiro Kawase; Tadamitsu Kishimoto; Tetsuji Naka
Suppressor of cytokine signaling 1 suppresses muscle differentiation through modulation of IGF-I receptor signal transduction.
Biochemical and biophysical research communications 2005;328(4):953-61.
2005: Shumpei Yokota; Takako Miyamae; Tomoyuki Imagawa; Naomi Iwata; Shigeki Katakura; Masaaki Mori; Patricia Woo; Norihiro Nishimoto; Kazuyuki Yoshizaki; Tadamitsu Kishimoto
Therapeutic efficacy of humanized recombinant anti-interleukin-6 receptor antibody in children with systemic-onset juvenile idiopathic arthritis.
Arthritis and rheumatism 2005;52(3):818-25.
2005: Ekihiro Seki; Hiroko Tsutsui; Yuji Iimuro; Tetsuji Naka; Gakuhei Son; Shizuo Akira; Tadamitsu Kishimoto; Kenji Nakanishi; Jiro Fujimoto
Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration.
Hepatology (Baltimore, Md.) 2005;41(3):443-50.
2005: Aysefa Doganci; Tatjana Eigenbrod; Norbert Krug; George T De Sanctis; Michael Hausding; Veit J Erpenbeck; El-Bdaoui Haddad; Hans-Anton Lehr; Edgar Schmitt; Tobias Bopp; Karl-Josef Kallen; Udo Herz; Steffen Schmitt; Cornelia Luft; Oliver Hecht; Jens Hohlfeld; Hiroaki Ito; Norihiro Nishimoto; Kazuyuki Yoshizaki; Tadamitsu Kishimoto; Stefan Rose-John; Harald Renz; Markus F Neurath; Peter R Galle; Susetta Finotto
The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo.
The Journal of clinical investigation 2005;115(2):313-25.
2005: Yuichi Oshima; Yasushi Fujio; Tsuyoshi Nakanishi; Norio Itoh; Yasuhiro Yamamoto; Shinji Negoro; Keiichi Tanaka; Tadamitsu Kishimoto; Ichiro Kawase; Junichi Azuma
STAT3 mediates cardioprotection against ischemia/reperfusion injury through metallothionein induction in the heart.
Cardiovascular research 2005;65(2):428-35.
2005: Patricia Woo; Nicholas Wilkinson; Anne-Marie Prieur; Taunton R Southwood; Valentina Leone; Polly Livermore; Helena Wythe; David Thomson; Tadamitsu Kishimoto
Open label phase II trial of single, ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis: proof of principle of the efficacy of IL-6 receptor blockade in this type of arthritis and demonstration of prolonged clinical improvement.
Arthritis research & therapy 2005;7(6):R1281-8.
2005: Tadamitsu Kishimoto
Interleukin-6: from basic science to medicine--40 years in immunology.
Annual review of immunology 2005;23():1-21.
2004: Dai Watanabe; Tetsuji Naka; Tadamitsu Kishimoto
Implication of SOCS-1 gene methylation in acute myeloid leukaemia.
British journal of haematology 2004;127(5):608-9.
2004: Akane Kunitomi; Yoshiteru Konaka; Masato Yagita; Norihiro Nishimoto; Tadamitsu Kishimoto; Kiyoshi Takatsuki
Humanized anti-interleukin 6 receptor antibody induced long-term remission in a patient with life-threatening refractory autoimmune hemolytic anemia.
International journal of hematology 2004;80(3):246-9.
2004: Christoph Becker; Massimo C Fantini; Christoph Schramm; Hans-Anton Lehr; Stefan Wirtz; Alexei Nikolaev; Jürgen Burg; Susanne Strand; Ralf Kiesslich; Samuel Huber; Hiroaki Ito; Norihiro Nishimoto; Kazuyuki Yoshizaki; Tadamitsu Kishimoto; Peter R Galle; Manfred Blessing; Stefan Rose-John; Markus F Neurath
TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.
Immunity 2004;21(4):491-501.
2004: Dai Watanabe; Sachiko Ezoe; Minoru Fujimoto; Akihiro Kimura; Yoshiyuki Saito; Hisaki Nagai; Isao Tachibana; Itaru Matsumura; Toshio Tanaka; Hirokazu Kanegane; Toshio Miyawaki; Mitsuru Emi; Yuzuru Kanakura; Ichiro Kawase; Tetsuji Naka; Tadamitsu Kishimoto
Suppressor of cytokine signalling-1 gene silencing in acute myeloid leukaemia and human haematopoietic cell lines.
British journal of haematology 2004;126(5):726-35.
2004: Yasushi Fujio; Takahisa Matsuda; Yuichi Oshima; Makiko Maeda; Tomomi Mohri; Takashi Ito; Tomoka Takatani; Mayo Hirata; Yoshikazu Nakaoka; Ryusuke Kimura; Tadamitsu Kishimoto; Junichi Azuma
Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes.
FEBS letters 2004;573(1-3):202-6.
2004: Norihiro Nishimoto; Tadamitsu Kishimoto
Inhibition of IL-6 for the treatment of inflammatory diseases.
Current opinion in pharmacology 2004;4(4):386-91.
2004: Akihiro Kimura; Tetsuji Naka; Shigekazu Nagata; Ichiro Kawase; Tadamitsu Kishimoto
SOCS-1 suppresses TNF-alpha-induced apoptosis through the regulation of Jak activation.
International immunology 2004;16(7):991-9.
2004: Norihiro Nishimoto; Kazuyuki Yoshizaki; Nobuyuki Miyasaka; Kazuhiko Yamamoto; Shinichi Kawai; Tsutomu Takeuchi; Jun Hashimoto; Junichi Azuma; Tadamitsu Kishimoto
Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial.
Arthritis and rheumatism 2004;50(6):1761-9.
2004: Masahiko Mihara; Masashi Shiina; Norihiro Nishimoto; Kazuyuki Yoshizaki; Tadamitsu Kishimoto; Ken-Ichi Akamatsu
Anti-interleukin 6 receptor antibody inhibits murine AA-amyloidosis.
The Journal of rheumatology 2004;31(6):1132-8.
2004: Toshiaki Komazaki; Hisaki Nagai; Mitsuru Emi; Yoshie Terada; Aya Yabe; Enjing Jin; Oichi Kawanami; Noboru Konishi; Yukichi Moriyama; Tetsuji Naka; Tadamitsu Kishimoto
Hypermethylation-associated inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human pancreatic cancers.
Japanese journal of clinical oncology 2004;34(4):191-4.
2004: Hiroaki Ito; Masakazu Takazoe; Yoshihiro Fukuda; Toshifumi Hibi; Kazuo Kusugami; Akira Andoh; Takayuki Matsumoto; Takehira Yamamura; Junichi Azuma; Norihiro Nishimoto; Kazuyuki Yoshizaki; Takashi Shimoyama; Tadamitsu Kishimoto
A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease.
Gastroenterology 2004;126(4):989-96; discussion 947.
2004: Minoru Fujimoto; Hiroko Tsutsui; Ouyang Xinshou; Masanori Tokumoto; Dai Watanabe; Yoshihito Shima; Tomohiro Yoshimoto; Hideki Hirakata; Ichiro Kawase; Kenji Nakanishi; Tadamitsu Kishimoto; Tetsuji Naka
Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases.
International immunology 2004;16(2):303-14.
2003: Norihiro Nishimoto; Kazuyuki Yoshizaki; Keiji Maeda; Taro Kuritani; Hitoshi Deguchi; Bunzo Sato; Nobuyuki Imai; Masaki Suemura; Takahiro Kakehi; Nobuhiro Takagi; Tadamitsu Kishimoto
Toxicity, pharmacokinetics, and dose-finding study of repetitive treatment with the humanized anti-interleukin 6 receptor antibody MRA in rheumatoid arthritis. Phase I/II clinical study.
The Journal of rheumatology 2003;30(7):1426-35.
2003: Hideko Nakahara; Jian Song; Masamichi Sugimoto; Keisuke Hagihara; Tadamitsu Kishimoto; Kazuyuki Yoshizaki; Norihiro Nishimoto
Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis.
Arthritis and rheumatism 2003;48(6):1521-9.
2003: Toshiaki Ara; Yuri Nakamura; Takeshi Egawa; Tatsuki Sugiyama; Kuniya Abe; Tadamitsu Kishimoto; Yasuhisa Matsui; Takashi Nagasawa
Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1).
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5319-23.
2003: Takayuki Okamura; Tadamitsu Kishimoto; Masami Inoue; M Honda; N Yamashita; H Wakiguchi; Masato Yagita; G Hosoi; M Sako; Masahiro Yasui; K Yagi; Keisei Kawa
Unrelated bone marrow transplantation for Epstein-Barr virus-associated T/NK-cell lymphoproliferative disease.
Bone marrow transplantation 2003;31(2):105-11.
2003: Hisaki Nagai; Tetsuji Naka; Yoshie Terada; Toshiaki Komazaki; Aya Yabe; Enjing Jin; Oichi Kawanami; Tadamitsu Kishimoto; Noboru Konishi; Mitsutoshi Nakamura; Yasuhito Kobayashi; Mitsuru Emi
Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human hepatoblastomas.
Journal of human genetics 2003;48(2):65-9.
2003: Norihiko Yamaguchi; Shiro Ohshima; Mitsuko Umeshita-Sasai; Katsuhiro Nishioka; Hideyuki Kobayashi; Toru Mima; Tadamitsu Kishimoto; Yukihiko Saeki
Synergistic effect on the attenuation of collagen induced arthritis in tumor necrosis factor receptor I (TNFRI) and interleukin 6 double knockout mice.
The Journal of rheumatology 2003;30(1):22-7.
2002: Asao Katsume; Hiroyuki Saito; Yoshiki Yamada; Keigo Yorozu; Otoya Ueda; Ken-ichi Akamatsu; Norihiro Nishimoto; Tadamitsu Kishimoto; Kazuyuki Yoshizaki; Yoshiyuki Ohsugi
Anti-interleukin 6 (IL-6) receptor antibody suppresses Castleman's disease like symptoms emerged in IL-6 transgenic mice.
Cytokine 2002;20(6):304-11.
2002: Hiroaki Ito; Tomonori Hirotani; Mitsunari Yamamoto; Hiroyuki Ogawa; Tadamitsu Kishimoto
Anti-IL-6 receptor monoclonal antibody inhibits leukocyte recruitment and promotes T-cell apoptosis in a murine model of Crohn's disease.
Journal of gastroenterology 2002;37 Suppl 14():56-61.
2002: Reiko Nakagawa; Tetsuji Naka; Hiroko Tsutsui; Minoru Fujimoto; Akihiro Kimura; Tatsuo Abe; Ekihiro Seki; Shintaro Sato; Osamu Takeuchi; Kiyoshi Takeda; Shizuo Akira; Koichi Yamanishi; Ichirou Kawase; Kenji Nakanishi; Tadamitsu Kishimoto
SOCS-1 participates in negative regulation of LPS responses.
Immunity 2002;17(5):677-87.
2002: Minoru Fujimoto; Hiroko Tsutsui; Shizue Yumikura-Futatsugi; Haruyasu Ueda; Ouyang Xingshou; Tatsuo Abe; Ichiro Kawase; Kenji Nakanishi; Tadamitsu Kishimoto; Tetsuji Naka
A regulatory role for suppressor of cytokine signaling-1 in T(h) polarization in vivo.
International immunology 2002;14(11):1343-50.
2002: Yoh-Ichi Seki; Katsuhiko Hayashi; Akira Matsumoto; Noriyasu Seki; Jun Tsukada; John Ransom; Tetsuji Naka; Tadamitsu Kishimoto; Akihiko Yoshimura; Masato Kubo
Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):13003-8.
2002: Hideyuki Kobayashi; Shiro Ohshima; Katsuhiro Nishioka; Norihiko Yamaguchi; Mitsuko Umeshita-Sasai; Taeko Ishii; Toru Mima; Tadamitsu Kishimoto; Ichiro Kawase; Yukihiko Saeki
Antigen induced arthritis (AIA) can be transferred by bone marrow transplantation: evidence that interleukin 6 is essential for induction of AIA.
The Journal of rheumatology 2002;29(6):1176-82.
2002: Hirohisa Suido; Toshio Tanaka; Toshio Tabei; Akira Takeuchi; Misako Okita; Tadamitsu Kishimoto; Soji Kasayama; Kazuya Higashino
A mixed green vegetable and fruit beverage decreased the serum level of low-density lipoprotein cholesterol in hypercholesterolemic patients.
Journal of agricultural and food chemistry 2002;50(11):3346-50.
2002: Olga A Elisseeva; Yoshihiro Oka; Akihiro Tsuboi; Kiyoyuki Ogata; Fei Wu; Eui Ho Kim; Toshihiro Soma; Hiroya Tamaki; Manabu Kawakami; Yusuke Oji; Naoki Hosen; Takeshi Kubota; Masashi Nakagawa; Tamotsu Yamagami; Akira Hiraoka; Machiko Tsukaguchi; Keiko Udaka; Hiroyasu Ogawa; Tadamitsu Kishimoto; Taisei Nomura; Haruo Sugiyama
Humoral immune responses against Wilms tumor gene WT1 product in patients with hematopoietic malignancies.
Blood 2002;99(9):3272-9.
2002: Shigeru Sakuda; Shinji Tamura; Akira Yamada; Jun-ichiro Miyagawa; Koji Yamamoto; Shinichi Kiso; Nobuyuki Ito; Kazuho Imanaka; Akira Wada; Tetsuji Naka; Tadamitsu Kishimoto; Sumio Kawata; Yuji Matsuzawa
Activation of signal transducer and activator transcription 3 and expression of suppressor of cytokine signal 1 during liver regeneration in rats.
Journal of hepatology 2002;36(3):378-84.
2002: Tomoaki Osugi; Yuichi Oshima; Yasushi Fujio; Masanobu Funamoto; Atsuko Yamashita; Shinji Negoro; Keita Kunisada; Masahiro Izumi; Yoshikazu Nakaoka; Hisao Hirota; Masaru Okabe; Keiko Yamauchi-Takihara; Ichiro Kawase; Tadamitsu Kishimoto
Cardiac-specific activation of signal transducer and activator of transcription 3 promotes vascular formation in the heart.
The Journal of biological chemistry 2002;277(8):6676-81.
2002: Alexander L Kovalchuk; Joong Su Kim; Sung Sup Park; Allen E Coleman; Jerrold M Ward; Herbert C Morse; Tadamitsu Kishimoto; Michael Potter; Siegfried Janz
IL-6 transgenic mouse model for extraosseous plasmacytoma.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1509-14.
2002: Motonobu Matsumoto; Mayumi Kotani; Akihito Fujita; Shinji Higa; Tadamitsu Kishimoto; Masaki Suemura; Toshiyuki Tanaka
Oral administration of persimmon leaf extract ameliorates skin symptoms and transepidermal water loss in atopic dermatitis model mice, NC/Nga.
The British journal of dermatology 2002;146(2):221-7.
2002: Tetsuji Naka; Norihiro Nishimoto; Tadamitsu Kishimoto
The paradigm of IL-6: from basic science to medicine.
Arthritis research 2002;4 Suppl 3():S233-42.
2002: Tetsuji Naka; Tadamitsu Kishimoto
Joint disease caused by defective gp130-mediated STAT signaling.
Arthritis research 2002;4(3):154-6.
2001: Masato Yagita; Hiroshi Iwakura; Tadamitsu Kishimoto; Takayuki Okamura; Akane Kunitomi; R Tabata; Yoshiteru Konaka; Keisei Kawa
Successful allogeneic stem cell transplantation from an unrelated donor for aggressive Epstein-Barr virus-associated clonal T-cell proliferation with hemophagocytosis.
International journal of hematology 2001;74(4):451-4.
2001: Yoshiyasu Aoki; masashi narazaki; Tadamitsu Kishimoto; Giovanna Tosato
Receptor engagement by viral interleukin-6 encoded by Kaposi sarcoma-associated herpesvirus.
Blood 2001;98(10):3042-9.
2001: D Watanabe; Shouji Hashimoto; M Ishiai; M Matsushita; Y Baba; Tadamitsu Kishimoto; Tomohiro Kurosaki; Satoshi Tsukada
Four tyrosine residues in phospholipase C-gamma 2, identified as Btk-dependent phosphorylation sites, are required for B cell antigen receptor-coupled calcium signaling.
The Journal of biological chemistry 2001;276(42):38595-601.
2001: Elizabeth Crabb Breen; Julia R Gage; Beichu Guo; L Magpantay; masashi narazaki; Tadamitsu Kishimoto; S Miles; Otoniel Martínez-Maza
Viral interleukin 6 stimulates human peripheral blood B cells that are unresponsive to human interleukin 6.
Cellular immunology 2001;212(2):118-25.
2001: Shinji Negoro; Keita Kunisada; Yasushi Fujio; Masanobu Funamoto; Martine I Darville; D L Eizirik; Tomoaki Osugi; Masahiro Izumi; Yuichi Oshima; Yoshikazu Nakaoka; Hisao Hirota; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara
Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutase.
Circulation 2001;104(9):979-81.
2001: Masahiro Izumi; Yasushi Fujio; Keita Kunisada; Shinji Negoro; Eiroh Tone; Masanobu Funamoto; Tomoaki Osugi; Yuichi Oshima; Yoshikazu Nakaoka; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara; Hisao Hirota
Bone morphogenetic protein-2 inhibits serum deprivation-induced apoptosis of neonatal cardiac myocytes through activation of the Smad1 pathway.
The Journal of biological chemistry 2001;276(33):31133-41.
2001: Takeshi Egawa; Kenji Kawabata; H Kawamoto; K Amada; R Okamoto; N Fujii; Tadamitsu Kishimoto; Y Katsura; Takashi Nagasawa
The earliest stages of B cell development require a chemokine stromal cell-derived factor/pre-B cell growth-stimulating factor.
Immunity 2001;15(2):323-34.
2001: Yu-Chun Wang; Toshiyuki Tanaka; H Okamura; M Sugita; Shinji Higa; Tadamitsu Kishimoto; Masaki Suemura
Interleukin-18 enhances the production of interleukin-8 by eosinophils.
European journal of immunology 2001;31(4):1010-6.
2001: Masahiko Mihara; M Kotoh; Norihiro Nishimoto; Y Oda; E Kumagai; N Takagi; K Tsunemi; Yoshiyuki Ohsugi; Tadamitsu Kishimoto; Kazuyuki Yoshizaki; Y Takeda
Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys.
Clinical immunology (Orlando, Fla.) 2001;98(3):319-26.
2001: Y Baba; Shouji Hashimoto; M Matsushita; D Watanabe; Tadamitsu Kishimoto; Tomohiro Kurosaki; Satoshi Tsukada
BLNK mediates Syk-dependent Btk activation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2582-6.
2001: Toshiyuki Tanaka; Yoshinori Katada; Shinji Higa; Hiromi Fujiwara; Yu-Chun Wang; Yukihiko Saeki; Shiro Ohshima; Y Okuda; Masaki Suemura; Tadamitsu Kishimoto
Enhancement of T helper2 response in the absence of interleukin (IL-)6; an inhibition of IL-4-mediated T helper2 cell differentiation by IL-6.
Cytokine 2001;13(4):193-201.
2001: Noritoshi Koh; Toshihiko Fujimori; S Nishiguchi; A Tamori; S Shiomi; T Nakatani; K Sugimura; Tadamitsu Kishimoto; Shigeru Kinoshita; Tetsuo Kuroki; Yo-ichi Nabeshima
Severely reduced production of klotho in human chronic renal failure kidney.
Biochemical and biophysical research communications 2001;280(4):1015-20.
2001: Michio Otsuki; Hiroshi Saito; Xin Xu; Satoru Sumitani; Haruhiko Kouhara; Tadamitsu Kishimoto; Soji Kasayama
Progesterone, but not medroxyprogesterone, inhibits vascular cell adhesion molecule-1 expression in human vascular endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(2):243-8.
2001: Shinji Negoro; H Oh; Eiroh Tone; Keita Kunisada; Yasushi Fujio; K Walsh; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara
Glycoprotein 130 regulates cardiac myocyte survival in doxorubicin-induced apoptosis through phosphatidylinositol 3-kinase/Akt phosphorylation and Bcl-xL/caspase-3 interaction.
Circulation 2001;103(4):555-61.
2001: Y Kawazoe; Tetsuji Naka; Minoru Fujimoto; H Kohzaki; Y Morita; Michiko Narazaki; Koichi Okumura; H Saitoh; Reiko Nakagawa; Y Uchiyama; Shizuo Akira; Tadamitsu Kishimoto
Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation.
The Journal of experimental medicine 2001;193(2):263-9.
2000: Julia R Gage; A K Sandhu; M Nihira; G Bonecini-Almeida M da; P Cristoforoni; Tadamitsu Kishimoto; FJ Montz; Otoniel Martínez-Maza
Effects of human papillomavirus-associated cells on human immunodeficiency virus gene expression.
Obstetrics and gynecology 2000;96(6):879-85.
2000: Norihiro Nishimoto; Tadamitsu Kishimoto; Kazuyuki Yoshizaki
Anti-interleukin 6 receptor antibody treatment in rheumatic disease.
Annals of the rheumatic diseases 2000;59 Suppl 1():i21-7.
2000: Keiko Yamauchi-Takihara; Tadamitsu Kishimoto
A novel role for STAT3 in cardiac remodeling.
Trends in cardiovascular medicine 2000;10(7):298-303.
2000: Tadamitsu Kishimoto
[Immunology in the 20th century--progress made in research on infectious and immunological diseases].
Kekkaku : [Tuberculosis] 2000;75(10):595-8.
2000: Eiroh Tone; Keita Kunisada; Atsushi Kumanogoh; Shinji Negoro; Masanobu Funamoto; Tomoaki Osugi; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara
gp130-Dependent signalling pathway is not enhanced in gp130 transgenic heart after LIF stimulation.
Cytokine 2000;12(10):1512-8.
2000: Shinji Negoro; Keita Kunisada; Eiroh Tone; Masanobu Funamoto; H Oh; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara
Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction.
Cardiovascular research 2000;47(4):797-805.
2000: Minoru Fujimoto; Tetsuji Naka; Reiko Nakagawa; Y Kawazoe; Y Morita; A Tateishi; Koichi Okumura; Michiko Narazaki; Tadamitsu Kishimoto
Defective thymocyte development and perturbed homeostasis of T cells in STAT-induced STAT inhibitor-1/suppressors of cytokine signaling-1 transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):1799-806.
2000: Keiko Nomura; Hirokazu Kanegane; H Karasuyama; Satoshi Tsukada; Kazunaga Agematsu; G Murakami; S Sakazume; M Sako; R Tanaka; Y Kuniya; T Komeno; S Ishihara; K Hayashi; Tadamitsu Kishimoto; Toshio Miyawaki
Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway.
Blood 2000;96(2):610-7.
2000: Katsuhiro Nishioka; Shiro Ohshima; Mitsuko Umeshita-Sasai; Norihiko Yamaguchi; Toru Mima; Shintaro Nomura; Norikazu Murata; M Shimizu; T Miyake; Kazuyuki Yoshizaki; Masaki Suemura; Tadamitsu Kishimoto; Yukihiko Saeki
Enhanced expression and DNA binding activity of two CCAAT/enhancer-binding protein isoforms, C/EBPbeta and C/EBPdelta, in rheumatoid synovium.
Arthritis and rheumatism 2000;43(7):1591-6.
2000: Mayumi Kotani; Motonobu Matsumoto; Akihito Fujita; Shinji Higa; Yu-Chun Wang; Masaki Suemura; Tadamitsu Kishimoto; Toshiyuki Tanaka
Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice.
The Journal of allergy and clinical immunology 2000;106(1 Pt 1):159-66.
2000: Masanobu Funamoto; S Hishinuma; Yasushi Fujio; Y Matsuda; Keita Kunisada; H Oh; Shinji Negoro; Eiroh Tone; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara
Isolation and characterization of the murine cardiotrophin-1 gene: expression and norepinephrine-induced transcriptional activation.
Journal of molecular and cellular cardiology 2000;32(7):1275-84.
2000: Alexander L Kovalchuk; Tadamitsu Kishimoto; Siegfried Janz
Lymph nodes and Peyer's patches of IL-6 transgenic BALB/c mice harbor T(12;15) translocated plasma cells that contain illegitimate exchanges between the immunoglobulin heavy-chain mu locus and c-myc.
Leukemia 2000;14(6):1127-35.
2000: Hiroshi Saito; Y Morita; Minoru Fujimoto; Michiko Narazaki; Tetsuji Naka; Tadamitsu Kishimoto
IFN regulatory factor-1-mediated transcriptional activation of mouse STAT-induced STAT inhibitor-1 gene promoter by IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(11):5833-43.
2000: Y Morita; Tetsuji Naka; Y Kawazoe; Minoru Fujimoto; Michiko Narazaki; Reiko Nakagawa; Hidenao Fukuyama; Shigekazu Nagata; Tadamitsu Kishimoto
Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5405-10.
2000: Akihiro Tsuboi; Yoshihiro Oka; Hiroyasu Ogawa; Olga A Elisseeva; Hanfen Li; Kotomi Kawasaki; Katsuyuki Aozasa; Tadamitsu Kishimoto; Keiko Udaka; Haruo Sugiyama
Cytotoxic T-lymphocyte responses elicited to Wilms' tumor gene WT1 product by DNA vaccination.
Journal of clinical immunology 2000;20(3):195-202.
2000: Raja Atreya; Jonas Mudter; Susetta Finotto; Jürgen Müllberg; Thomas Jostock; Stefan Wirtz; Michael Schütz; Brigitte Bartsch; Martin H Holtmann; Christoph Becker; Dennis Strand; Joachim Czaja; Joerg F Schlaak; Hans-Anton Lehr; Frank Autschbach; G Schürmann; Norihiro Nishimoto; Kazuyuki Yoshizaki; Hiroaki Ito; Tadamitsu Kishimoto; Peter R Galle; Stefan Rose-John; Markus F Neurath
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo.
Nature medicine 2000;6(5):583-8.
2000: Masahiro Yamamoto; Kazuyuki Yoshizaki; Tadamitsu Kishimoto; Hiroaki Ito
IL-6 is required for the development of Th1 cell-mediated murine colitis.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(9):4878-82.
2000: Masanobu Funamoto; Yasushi Fujio; Keita Kunisada; Shinji Negoro; Eiroh Tone; Tomoaki Osugi; Hisao Hirota; Masahiro Izumi; Kazuyuki Yoshizaki; K Walsh; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara
Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytes.
The Journal of biological chemistry 2000;275(14):10561-6.
2000: Aki Aono; H Enomoto; N Yoshida; K Yoshizaki; Tadamitsu Kishimoto; T Komori
Forced expression of terminal deoxynucleotidyl transferase in fetal thymus resulted in a decrease in gammadelta T cells and random dissemination of Vgamma3Vdelta1 T cells in skin of newborn but not adult mice.
Immunology 2000;99(4):489-97.
2000: Hirayuki Enomoto; Motomi Enomoto-Iwamoto; Masahiro Iwamoto; Shintaro Nomura; Miki Himeno; Yukihiko Kitamura; Tadamitsu Kishimoto; Toshihisa Komori
Cbfa1 is a positive regulatory factor in chondrocyte maturation.
The Journal of biological chemistry 2000;275(12):8695-702.
2000: S Uchida; Go Watanabe; Yutaka Shimada; Michiyuki Maeda; Atsushi Kawabe; A Mori; S Arii; Masayoshi Uehata; Tadamitsu Kishimoto; T Oikawa; Masayuki Imamura
The suppression of small GTPase rho signal transduction pathway inhibits angiogenesis in vitro and in vivo.
Biochemical and biophysical research communications 2000;269(2):633-40.
2000: Shiro Ohshima; Toru Mima; M Sasai; Katsuhiro Nishioka; M Shimizu; N Murata; H Yoshikawa; K Nakanishi; Masaki Suemura; RV McCloskey; Tadamitsu Kishimoto; Yukihiko Saeki
Tumour necrosis factor alpha (TNF-alpha) interferes with Fas-mediated apoptotic cell death on rheumatoid arthritis (RA) synovial cells: a possible mechanism of rheumatoid synovial hyperplasia and a clinical benefit of anti-TNF-alpha therapy for RA.
Cytokine 2000;12(3):281-8.
2000: Yoshihiro Oka; Keiko Udaka; Akihiro Tsuboi; Olga A Elisseeva; Hiroyasu Ogawa; Katsuyuki Aozasa; Tadamitsu Kishimoto; Haruo Sugiyama
Cancer immunotherapy targeting Wilms' tumor gene WT1 product.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(4):1873-80.
2000: Keiko Yamauchi-Takihara; Tadamitsu Kishimoto
Cytokines and their receptors in cardiovascular diseases--role of gp130 signalling pathway in cardiac myocyte growth and maintenance.
International journal of experimental pathology 2000;81(1):1-16.
2000: Yoshihiro Oka; Olga A Elisseeva; Akihiro Tsuboi; Hiroyasu Ogawa; Hiroya Tamaki; Hanfen Li; Yusuke Oji; Eui Ho Kim; Toshihiro Soma; Momotaro Asada; K Ueda; E Maruya; H Saji; Tadamitsu Kishimoto; Keiko Udaka; Haruo Sugiyama
Human cytotoxic T-lymphocyte responses specific for peptides of the wild-type Wilms' tumor gene (WT1 ) product.
Immunogenetics 2000;51(2):99-107.
2000: Keita Kunisada; Shinji Negoro; Eiroh Tone; Masanobu Funamoto; Tomoaki Osugi; S Yamada; Masaru Okabe; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara
Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(1):315-9.
2000: Norihiro Nishimoto; M Sasai; Yoshihito Shima; Masashi Nakagawa; Takayuki Matsumoto; T Shirai; Tadamitsu Kishimoto; Kazuyuki Yoshizaki
Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy.
Blood 2000;95(1):56-61.
1999: Kazuhiro Ikegame; Masahiro Yamamoto; Yoshihiko Kishima; Hirayuki Enomoto; Kenji Yoshida; Masaki Suemura; Tadamitsu Kishimoto; Hitomi Nakamura
A new member of a hepatoma-derived growth factor gene family can translocate to the nucleus.
Biochemical and biophysical research communications 1999;266(1):81-7.
1999: Masasuke Yoshida; J Sakuma-Mochizuki; Kin'ya Abe; Toru Arai; Masahide Mori; Sho Goya; Hiroaki Matsuoka; Seiji Hayashi; Yasufumi Kaneda; Tadamitsu Kishimoto
In vivo gene transfer of an extracellular domain of platelet-derived growth factor beta receptor by the HVJ-liposome method ameliorates bleomycin-induced pulmonary fibrosis.
Biochemical and biophysical research communications 1999;265(2):503-8.
1999: Yoshinobu Okuda; Saburo Sakoda; Harutoshi Fujimura; Y Saeki; Tadamitsu Kishimoto; Takehiko Yanagihara
IL-6 plays a crucial role in the induction phase of myelin oligodendrocyte glucoprotein 35-55 induced experimental autoimmune encephalomyelitis.
Journal of neuroimmunology 1999;101(2):188-96.
1999: Julia R Gage; Elizabeth Crabb Breen; Angela Echeverri; L Magpantay; Tadamitsu Kishimoto; S Miles; Otoniel Martínez-Maza
Human herpesvirus 8-encoded interleukin 6 activates HIV-1 in the U1 monocytic cell line.
AIDS (London, England) 1999;13(14):1851-5.
1999: Tetsuji Naka; Minoru Fujimoto; Tadamitsu Kishimoto
Negative regulation of cytokine signaling: STAT-induced STAT inhibitor.
Trends in biochemical sciences 1999;24(10):394-8.
1999: Shouji Hashimoto; A Iwamatsu; M Ishiai; K Okawa; Tomoki Yamadori; M Matsushita; Y Baba; Tadamitsu Kishimoto; Tomohiro Kurosaki; Satoshi Tsukada
Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling.
Blood 1999;94(7):2357-64.
1999: Toru Mima; Shiro Ohshima; M Sasai; Katsuhiro Nishioka; M Shimizu; N Murata; R Yasunami; H Matsuno; Masaki Suemura; Tadamitsu Kishimoto; Yukihiko Saeki
Dominant and shared T cell receptor beta chain variable regions of T cells inducing synovial hyperplasia in rheumatoid arthritis.
Biochemical and biophysical research communications 1999;263(1):172-80.
1999: Shiro Ohshima; Yukihiko Saeki; Toru Mima; M Sasai; Katsuhiro Nishioka; H Ishida; M Shimizu; Masaki Suemura; RV McCloskey; Tadamitsu Kishimoto
Long-term follow-up of the changes in circulating cytokines, soluble cytokine receptors, and white blood cell subset counts in patients with rheumatoid arthritis (RA) after monoclonal anti-TNF alpha antibody therapy.
Journal of clinical immunology 1999;19(5):305-13.
1999: Shouji Hashimoto; T Miyawaki; Takeshi Futatani; Hirokazu Kanegane; Kazuhiro Usui; T Nukiwa; S Namiuchi; M Matsushita; Tomoki Yamadori; Masaki Suemura; Tadamitsu Kishimoto; Satoshi Tsukada
Atypical X-linked agammaglobulinemia diagnosed in three adults.
Internal medicine (Tokyo, Japan) 1999;38(9):722-5.
1999: Elizabeth Crabb Breen; M van der Meijden; William G Cumberland; Tadamitsu Kishimoto; Roger Detels; Otoniel Martínez-Maza
The development of AIDS-associated Burkitt's/small noncleaved cell lymphoma is preceded by elevated serum levels of interleukin 6.
Clinical immunology (Orlando, Fla.) 1999;92(3):293-9.
1999: T Kuroda; Hiromitsu Tanaka; Hitomi Nakamura; Yoshitake Nishimune; Tadamitsu Kishimoto
Hepatoma-derived growth factor-related protein (HRP)-1 gene in spermatogenesis in mice.
Biochemical and biophysical research communications 1999;262(2):433-7.
1999: M Sasai; Yukihiko Saeki; Shiro Ohshima; Katsuhiro Nishioka; Toru Mima; Toshiyuki Tanaka; Yoshinori Katada; Kazuyuki Yoshizaki; Masaki Suemura; Tadamitsu Kishimoto
Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6-deficient mice.
Arthritis and rheumatism 1999;42(8):1635-43.
1999: Tomoki Yamadori; Y Baba; M Matsushita; Shouji Hashimoto; M Kurosaki; Tomohiro Kurosaki; Tadamitsu Kishimoto; Satoshi Tsukada
Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6341-6.
1999: Kenji Kawabata; M Ujikawa; Takeshi Egawa; H Kawamoto; K Tachibana; H Iizasa; Y Katsura; Tadamitsu Kishimoto; Takashi Nagasawa
A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5663-7.
1999: Akihiro Tsuboi; Yoshihiro Oka; Hiroyasu Ogawa; Olga A Elisseeva; Hiroya Tamaki; Yusuke Oji; Eui Ho Kim; Toshihiro Soma; Toyoshi Tatekawa; Manabu Kawakami; Tadamitsu Kishimoto; Haruo Sugiyama
Constitutive expression of the Wilms' tumor gene WT1 inhibits the differentiation of myeloid progenitor cells but promotes their proliferation in response to granulocyte-colony stimulating factor (G-CSF).
Leukemia research 1999;23(5):499-505.
1999: H Matsui; Y Ihara; Yasushi Fujio; Keita Kunisada; Shizuo Akira; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara
Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-kappa B and NF-IL6 in cardiac myocytes.
Cardiovascular research 1999;42(1):104-12.
1999: M Inada; Takahiro Yasui; Shintaro Nomura; S Miyake; K Deguchi; Miki Himeno; Mitsunobu Sato; H Yamagiwa; T Kimura; N Yasui; Takahiro Ochi; N Endo; Yukihiko Kitamura; Tadamitsu Kishimoto; Toshihisa Komori
Maturational disturbance of chondrocytes in Cbfa1-deficient mice.
Developmental dynamics : an official publication of the American Association of Anatomists 1999;214(4):279-90.
1999: Y Baba; Shigeaki Nonoyama; M Matsushita; Tomoki Yamadori; Shouji Hashimoto; K Imai; S Arai; T Kunikata; M Kurimoto; Tomohiro Kurosaki; Hans D Ochs; Jun-Ichi Yata; Tadamitsu Kishimoto; Satoshi Tsukada
Involvement of wiskott-aldrich syndrome protein in B-cell cytoplasmic tyrosine kinase pathway.
Blood 1999;93(6):2003-12.
1999: Hiroya Tamaki; Hiroyasu Ogawa; K Ohyashiki; J H Ohyashiki; H Iwama; K Inoue; Toshihiro Soma; Yoshihiro Oka; Toyoshi Tatekawa; Yusuke Oji; Akihiro Tsuboi; Eui Ho Kim; Manabu Kawakami; K Fuchigami; M Tomonaga; K Toyama; Katsuyuki Aozasa; Tadamitsu Kishimoto; Haruo Sugiyama
The Wilms' tumor gene WT1 is a good marker for diagnosis of disease progression of myelodysplastic syndromes.
Leukemia 1999;13(3):393-9.
1999: Satoshi Ezaki; Norihiro Maeda; Tadamitsu Kishimoto; Haruyuki Atomi; Tadayuki Imanaka
Presence of a structurally novel type ribulose-bisphosphate carboxylase/oxygenase in the hyperthermophilic archaeon, Pyrococcus kodakaraensis KOD1.
The Journal of biological chemistry 1999;274(8):5078-82.
1999: K Deguchi; H Yagi; M Inada; Kazuyuki Yoshizaki; Tadamitsu Kishimoto; Toshihisa Komori
Excessive extramedullary hematopoiesis in Cbfa1-deficient mice with a congenital lack of bone marrow.
Biochemical and biophysical research communications 1999;255(2):352-9.
1999: Norihiro Nishimoto; Tadamitsu Kishimoto; Kazuyuki Yoshizaki
Anticytokine therapy in autoimmune diseases.
Internal medicine (Tokyo, Japan) 1999;38(2):178-82.
1999: Yusuke Oji; Hiroyasu Ogawa; Hiroya Tamaki; Yoshihiro Oka; Akihiro Tsuboi; Eui Ho Kim; Toshihiro Soma; Toyoshi Tatekawa; Manabu Kawakami; Momotaro Asada; Tadamitsu Kishimoto; Haruo Sugiyama
Expression of the Wilms' tumor gene WT1 in solid tumors and its involvement in tumor cell growth.
Japanese journal of cancer research : Gann 1999;90(2):194-204.
1999: P Yu; R A Morawetz; S Chattopadhyay; M Makino; Tadamitsu Kishimoto; Hitoshi Kikutani
CD40-deficient mice infected with the defective murine leukemia virus LP-BM5def do not develop murine AIDS but produce IgE and IgG1 in vivo.
European journal of immunology 1999;29(2):615-25.
1999: Masasuke Yoshida; Seiji Hayashi; J Sakuma-Mochizuki; Kin'ya Abe; Toru Arai; Masahide Mori; Sho Goya; Hiroaki Matsuoka; Yasufumi Kaneda; Tadamitsu Kishimoto
Introduction of plasmid DNA and oligonucleotides into lung epithelial cells by the hemagglutinating virus of Japan (HVJ)-liposome method.
Somatic cell and molecular genetics 1999;25(1):49-57.
1999: Y Baba; M Matsushita; Y Matsuda; Johji Inazawa; Tomoki Yamadori; S Hashimoto; Tadamitsu Kishimoto; Satoshi Tsukada
Assignment of SH3BP5/Sh3bp5 encoding sab, an SH3 domain-binding protein which preferentially associates with Bruton's tyrosine kinase, to human chromosome 1q43 and mouse chromosome 14B by in situ hybridization.
Cytogenetics and cell genetics 1999;87(3-4):221-2.
1998: Tetsuji Naka; Takuya Matsumoto; Michiko Narazaki; Minoru Fujimoto; Y Morita; Y Ohsawa; Hiroshi Saito; Takashi Nagasawa; Y Uchiyama; Tadamitsu Kishimoto
Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15577-82.
1998: M van der Meijden; Julia R Gage; Elizabeth Crabb Breen; T Taga; Tadamitsu Kishimoto; Otoniel Martínez-Maza
IL-6 receptor (CD126'IL-6R') expression is increased on monocytes and B lymphocytes in HIV infection.
Cellular immunology 1998;190(2):156-66.
1998: Eiroh Tone; Keita Kunisada; Yasushi Fujio; H Matsui; Shinji Negoro; H Oh; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara
Angiotensin II interferes with leukemia inhibitory factor-induced STAT3 activation in cardiac myocytes.
Biochemical and biophysical research communications 1998;253(1):147-50.
1998: Hirofumi Yamamoto; Tadamitsu Kishimoto; S Minamoto
NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4753-9.
1998: Michiko Narazaki; Minoru Fujimoto; Takuya Matsumoto; Y Morita; Hiroshi Saito; T Kajita; Kazuyuki Yoshizaki; Tetsuji Naka; Tadamitsu Kishimoto
Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):13130-4.
1998: Toshihisa Komori; Tadamitsu Kishimoto
Cbfa1 in bone development.
Current opinion in genetics & development 1998;8(4):494-9.
1998: Keita Kunisada; Eiroh Tone; Yasushi Fujio; H Matsui; Keiko Yamauchi-Takihara; Tadamitsu Kishimoto
Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes.
Circulation 1998;98(4):346-52.
1998: Shiro Ohshima; Yukihiko Saeki; Toru Mima; M Sasai; Katsuhiro Nishioka; Shintaro Nomura; M Kopf; Yoshinori Katada; Toshiyuki Tanaka; Masaki Suemura; Tadamitsu Kishimoto
Interleukin 6 plays a key role in the development of antigen-induced arthritis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(14):8222-6.
1998: I Imazeki; H Saito; M Hasegawa; Hirofumi Shinkura; Tadamitsu Kishimoto; Yoshiyuki Ohsugi
IL-6 functions in cynomolgus monkeys blocked by a humanized antibody to human IL-6 receptor.
International journal of immunopharmacology 1998;20(7):345-57.
1998: T Motomura; Soji Kasayama; M Takagi; Shogo Kurebayashi; H Matsui; Takahisa Hirose; Y Miyashita; Keiko Yamauchi-Takihara; Takehisa Yamamoto; Shintaro Okada; Tadamitsu Kishimoto
Increased interleukin-6 production in mouse osteoblastic MC3T3-E1 cells expressing activating mutant of the stimulatory G protein.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1998;13(7):1084-91.
1998: H Yagi; K Deguchi; Aki Aono; Y Tani; Tadamitsu Kishimoto; T Komori
Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice.
Blood 1998;92(1):108-17.
1998: K Tachibana; S Hirota; H Iizasa; H Yoshida; Kenji Kawabata; Y Kataoka; Y Kitamura; K Matsushima; N Yoshida; S Nishikawa; Tadamitsu Kishimoto; Takashi Nagasawa
The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract.
Nature 1998;393(6685):591-4.
1998: Takashi Nagasawa; K Tachibana; Tadamitsu Kishimoto
A novel CXC chemokine PBSF/SDF-1 and its receptor CXCR4: their functions in development, hematopoiesis and HIV infection.
Seminars in immunology 1998;10(3):179-85.
1998: Yoshinobu Okuda; Saburo Sakoda; CC Bernard; Harutoshi Fujimura; Y Saeki; Tadamitsu Kishimoto; Takehiko Yanagihara
IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein.
International immunology 1998;10(5):703-8.
1998: X J Wang; Tetsuya Taga; Kanji Yoshida; M Saito; Tadamitsu Kishimoto; Hitoshi Kikutani
gp130, the cytokine common signal-transducer of interleukin-6 cytokine family, is downregulated in T cells in vivo by interleukin-6.
Blood 1998;91(9):3308-14.
1998: M Matsushita; Tomoki Yamadori; S Kato; Y Takemoto; Johji Inazawa; Y Baba; Shouji Hashimoto; S Sekine; S Arai; T Kunikata; M Kurimoto; Tadamitsu Kishimoto; Satoshi Tsukada
Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (BtK).
Biochemical and biophysical research communications 1998;245(2):337-43.
1998: H Oh; Yasushi Fujio; Keita Kunisada; Hisao Hirota; H Matsui; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara
Activation of phosphatidylinositol 3-kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes.
The Journal of biological chemistry 1998;273(16):9703-10.
1998: K Inoue; Hiroya Tamaki; Hiroyasu Ogawa; Yoshihiro Oka; Toshihiro Soma; Toyoshi Tatekawa; Yusuke Oji; Akihiro Tsuboi; Eui Ho Kim; Manabu Kawakami; T Akiyama; Tadamitsu Kishimoto; Haruo Sugiyama
Wilms' tumor gene (WT1) competes with differentiation-inducing signal in hematopoietic progenitor cells.
Blood 1998;91(8):2969-76.
1998: Hiroyasu Ogawa; Haruo Sugiyama; Y Tani; Toshihiro Soma; Tamotsu Yamagami; Toyoshi Tatekawa; Yusuke Oji; T Kubota; Takafumi Kimura; K Inoue; M Nakagawa; K Sasaki; T Matsunashi; S Miyake; Tadamitsu Kishimoto
High incidence of chemotherapy-induced acral erythema in female patients with non-Hodgkin's lymphoma treated with the VACOP-B regimen.
Leukemia & lymphoma 1998;29(1-2):171-7.
1998: Takeshi Futatani; Toshio Miyawaki; Satoshi Tsukada; Shouji Hashimoto; T Kunikata; S Arai; M Kurimoto; Yo Niida; H Matsuoka; Yukio Sakiyama; T Iwata; S Tsuchiya; O Tatsuzawa; K Yoshizaki; Tadamitsu Kishimoto
Deficient expression of Bruton's tyrosine kinase in monocytes from X-linked agammaglobulinemia as evaluated by a flow cytometric analysis and its clinical application to carrier detection.
Blood 1998;91(2):595-602.
1998: Kazuyuki Yoshizaki; Norihiro Nishimoto; M Mihara; Tadamitsu Kishimoto
Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody.
Springer seminars in immunopathology 1998;20(1-2):247-59.
1998: Yukihiko Saeki; Shiro Ohshima; Toru Mima; M Sasai; Katsuhiro Nishioka; M Shimizu; Masaki Suemura; RV McCloskey; Tadamitsu Kishimoto
Suboptimal clinical response to anti-tumor necrosis factor alpha (TNFalpha) antibody therapy in a patient with severe rheumatoid arthritis and lymphadenopathy.
Scandinavian journal of rheumatology 1998;27(4):303-5.
1998: K Ueno; T Kumagai; T Kijima; Tadamitsu Kishimoto; S Hosoe
Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer.
Human genetics 1998;102(1):63-8.
1997: Shogo Kurebayashi; Takahisa Hirose; Y Miyashita; Soji Kasayama; Tadamitsu Kishimoto
Thiazolidinediones downregulate stearoyl-CoA desaturase 1 gene expression in 3T3-L1 adipocytes.
Diabetes 1997;46(12):2115-8.
1997: M Otsuki; K Hashimoto; Y Morimoto; Tadamitsu Kishimoto; Soji Kasayama
Circulating vascular cell adhesion molecule-1 (VCAM-1) in atherosclerotic NIDDM patients.
Diabetes 1997;46(12):2096-101.
1997: H Ogawa; H Ito; A Takeda; S Kanazawa; Masahiro Yamamoto; Hitomi Nakamura; Yoshinobu Kimura; Kazuyuki Yoshizaki; Tadamitsu Kishimoto
Universal skew of T cell receptor (TCR) V beta usage for Crohn's disease (CrD).
Biochemical and biophysical research communications 1997;240(3):545-51.
1997: Toshiaki Tsunenari; Y Koishihara; A Nakamura; M Moriya; H Ohkawa; H Goto; C Shimazaki; M Nakagawa; Yoshiyuki Ohsugi; Tadamitsu Kishimoto; Ken-ichi Akamatsu
New xenograft model of multiple myeloma and efficacy of a humanized antibody against human interleukin-6 receptor.
Blood 1997;90(6):2437-44.
1997: Y Izumoto; T Kuroda; Hidemitsu Harada; Tadamitsu Kishimoto; Hitomi Nakamura
Hepatoma-derived growth factor belongs to a gene family in mice showing significant homology in the amino terminus.
Biochemical and biophysical research communications 1997;238(1):26-32.
1997: S Minamoto; Kazuhiro Ikegame; K Ueno; Michiko Narazaki; Tetsuji Naka; Hirofumi Yamamoto; Takuya Matsumoto; Hiroshi Saito; S Hosoe; Tadamitsu Kishimoto
Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.
Biochemical and biophysical research communications 1997;237(1):79-83.
1997: Tetsuji Naka; Michiko Narazaki; M Hirata; Takuya Matsumoto; S Minamoto; A Aono; N Nishimoto; T Kajita; Tetsuya Taga; Kazuyuki Yoshizaki; S Akira; Tadamitsu Kishimoto
Structure and function of a new STAT-induced STAT inhibitor.
Nature 1997;387(6636):924-9.
1997: Yasushi Fujio; Keita Kunisada; Hisao Hirota; Keiko Yamauchi-Takihara; Tadamitsu Kishimoto
Signals through gp130 upregulate bcl-x gene expression via STAT1-binding cis-element in cardiac myocytes.
The Journal of clinical investigation 1997;99(12):2898-905.
1997: Harutoshi Fujimura; Yuji Nakatsuji; Saburo Sakoda; K Toyooka; Yoshinobu Okuda; H Yoshikawa; Misako Kaido; Y Saeki; T Mima; Tadamitsu Kishimoto; Takehiko Yanagihara
Demyelination in severe combined immunodeficient mice by intracisternal injection of cerebrospinal fluid cells from patients with multiple sclerosis: neuropathological investigation.
Acta neuropathologica 1997;93(6):567-78.
1997: Toshihisa Komori; H Yagi; Shintaro Nomura; Akihito Yamaguchi; K Sasaki; K Deguchi; Y Shimizu; R T Bronson; Y H Gao; M Inada; Mitsunobu Sato; R Okamoto; Yukihiko Kitamura; S Yoshiki; Tadamitsu Kishimoto
Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts.
Cell 1997;89(5):755-64.
1997: K Tachibana; T Nakajima; A Sato; K Igarashi; H Shida; H Iizasa; N Yoshida; O Yoshie; Tadamitsu Kishimoto; Takashi Nagasawa
CXCR4/fusin is not a species-specific barrier in murine cells for HIV-1 entry.
The Journal of experimental medicine 1997;185(10):1865-70.
1997: Takahisa Hirose; T Kuroda; Michio Otsuki; M Takagi; Hiroyasu Yamamoto; T Motomura; Shogo Kurebayashi; Y Miyashita; Masafumi Koga; Norio Arita; Takao Hayakawa; Tadamitsu Kishimoto; Soji Kasayama
A patient with acromegaly who showed remarkable improvement of hyperglycemia after treatment with octreotide.
Internal medicine (Tokyo, Japan) 1997;36(5):345-50.
1997: Masaki Inoue; M Minami; M Matsumoto; Tadamitsu Kishimoto; Shizuo Akira
The amino acid residues immediately carboxyl-terminal to the tyrosine phosphorylation site contribute to interleukin 6-specific activation of signal transducer and activator of transcription 3.
The Journal of biological chemistry 1997;272(14):9550-5.
1997: M Takagi; T Egawa; T Motomura; J Sakuma-Mochizuki; N Nishimoto; Soji Kasayama; Seiji Hayashi; Masafumi Koga; K Yoshizaki; T Yoshioka; A Okuyama; Tadamitsu Kishimoto
Interleukin-6 secreting phaeochromocytoma associated with clinical markers of inflammation.
Clinical endocrinology 1997;46(4):507-9.
1997: Atsushi Kumanogoh; Satoko Marukawa; T Kumanogoh; Hisao Hirota; Kanji Yoshida; I S Lee; T Yasui; K Yoshida; T Taga; Tadamitsu Kishimoto
Impairment of antigen-specific antibody production in transgenic mice expressing a dominant-negative form of gp130.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2478-82.
1997: M Takagi; Soji Kasayama; Takehisa Yamamoto; T Motomura; K Hashimoto; Hiroyasu Yamamoto; Bunzo Sato; Shintaro Okada; Tadamitsu Kishimoto
Advanced glycation endproducts stimulate interleukin-6 production by human bone-derived cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1997;12(3):439-46.
1997: K Inoue; Hiroyasu Ogawa; Yoshiaki Sonoda; Takafumi Kimura; H Sakabe; Yoshihiro Oka; S Miyake; Hiroya Tamaki; Yusuke Oji; Tamotsu Yamagami; Toyoshi Tatekawa; Toshihiro Soma; Tadamitsu Kishimoto; Haruo Sugiyama
Aberrant overexpression of the Wilms tumor gene (WT1) in human leukemia.
Blood 1997;89(4):1405-12.
1997: C Nakajima-Taniguchi; H Matsui; Yasushi Fujio; Seiki Nagata; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara
Novel missense mutation in cardiac troponin T gene found in Japanese patient with hypertrophic cardiomyopathy.
Journal of molecular and cellular cardiology 1997;29(2):839-43.
1997: Norihiro Nishimoto; Yoshihito Shima; Kazuyuki Yoshizaki; Tadamitsu Kishimoto
Myeloma biology and therapy. Present status and future developments.
Hematology/oncology clinics of North America 1997;11(1):159-72.
1997: Asao Katsume; T Miyai; H Suzuki; Y Moriguchi; H Kawata; T Tatsumi; S Suematsu; Tadamitsu Kishimoto; Yoshiyuki Ohsugi
Interleukin-6 overexpression cannot generate serious disorders in severe combined immunodeficiency mice.
Clinical immunology and immunopathology 1997;82(2):117-24.
1997: I S Lee; Y Liu; Michiko Narazaki; Masahiko Hibi; Tadamitsu Kishimoto; Tetsuya Taga
Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin-6.
FEBS letters 1997;401(2-3):133-7.
1997: Shogo Kurebayashi; Y Miyashita; Takahisa Hirose; Soji Kasayama; Shizuo Akira; Tadamitsu Kishimoto
Characterization of mechanisms of interleukin-6 gene repression by estrogen receptor.
The Journal of steroid biochemistry and molecular biology 1997;60(1-2):11-7.
1997: Tetsuya Taga; Tadamitsu Kishimoto
Gp130 and the interleukin-6 family of cytokines.
Annual review of immunology 1997;15():797-819.
1997: S Maruo; Masatsugu Oh-hora; Hyun-Jong Ahn; Shiro Ono; M Wysocka; Y Kaneko; Hideo Yagita; K Okumura; Hitoshi Kikutani; Tadamitsu Kishimoto; Masatoshi Kobayashi; Toshiyuki Hamaoka; G Trinchieri; Hiromi Fujiwara
B cells regulate CD40 ligand-induced IL-12 production in antigen-presenting cells (APC) during T cell/APC interactions.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(1):120-6.
1996: Keiko Yamauchi-Takihara; Hisao Hirota; Keita Kunisada; H Matsui; Yasushi Fujio; Tetsuya Taga; Tadamitsu Kishimoto
Roles of gp130 signaling pathways in cardiac myocytes: recent advances and implications for cardiovascular disease.
Journal of cardiac failure 1996;2(4 Suppl):S63-8.
1996: Hiroya Tamaki; Hiroyasu Ogawa; K Inoue; Toshihiro Soma; Tamotsu Yamagami; S Miyake; Yoshihiro Oka; Yusuke Oji; Toyoshi Tatekawa; Akihiro Tsuboi; S Tagawa; T Kitani; Katsuyuki Aozasa; Tadamitsu Kishimoto; Haruo Sugiyama; H Miwa; K Kita
Increased expression of the Wilms tumor gene (WT1) at relapse in acute leukemia.
Blood 1996;88(11):4396-8.
1996: Keita Kunisada; Hisao Hirota; Yasushi Fujio; H Matsui; Y Tani; Keiko Yamauchi-Takihara; Tadamitsu Kishimoto
Activation of JAK-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytes.
Circulation 1996;94(10):2626-32.
1996: Y Shima; N Nishimoto; K Yoshizaki; Tadamitsu Kishimoto
Fas antigen/APO-1 (CD95) expression on myeloma cells.
Leukemia & lymphoma 1996;23(5-6):521-31.
1996: Y Oka; Antonius G Rolink; J Andersson; M Kamanaka; J Uchida; T Yasui; Tadamitsu Kishimoto; Hitoshi Kikutani; Fritz Melchers
Profound reduction of mature B cell numbers, reactivities and serum Ig levels in mice which simultaneously carry the XID and CD40 deficiency genes.
International immunology 1996;8(11):1675-85.
1996: H Ochi; T Tanaka; Yoshinori Katada; T Naka; M Aitani; S Hashimoto; K Maeda; K Toyoshima; T Igarashi; Masaki Suemura; Tadamitsu Kishimoto
Peripheral blood T lymphocytes and basophils, freshly isolated from house-dust-mite-sensitive patients, produce interleukin-4 in response to allergen-specific stimulation.
International archives of allergy and immunology 1996;111(3):253-61.
1996: K Sasaki; H Yagi; R T Bronson; K Tominaga; T Matsunashi; K Deguchi; Y Tani; Tadamitsu Kishimoto; Toshihisa Komori
Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(22):12359-63.
1996: K Takeda; M Kamanaka; T Tanaka; Tadamitsu Kishimoto; S Akira
Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(8):3220-2.
1996: Isao Tachibana; Masahide Mori; Y Tanio; S Hosoe; T Sakuma; Tadashi Osaki; K Ueno; T Kumagai; T Kijima; Tadamitsu Kishimoto
A 100-kDa protein tyrosine phosphorylation is concurrent with beta 1 integrin-mediated morphological differentiation in neuroblastoma and small cell lung cancer cells.
Experimental cell research 1996;227(2):230-9.
1996: K Inoue; Hiroyasu Ogawa; Tamotsu Yamagami; Toshihiro Soma; Y Tani; Toyoshi Tatekawa; Yusuke Oji; Hiroya Tamaki; Taiichi Kyo; Hiroo Dohy; Akira Hiraoka; T Masaoka; Tadamitsu Kishimoto; Haruo Sugiyama
Long-term follow-up of minimal residual disease in leukemia patients by monitoring WT1 (Wilms tumor gene) expression levels.
Blood 1996;88(6):2267-78.
1996: Takashi Nagasawa; S Hirota; K Tachibana; N Takakura; S Nishikawa; Y Kitamura; N Yoshida; H Kikutani; Tadamitsu Kishimoto
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1.
Nature 1996;382(6592):635-8.
1996: D Watanabe; R Yoshimura; M Khalil; Kanji Yoshida; Tadamitsu Kishimoto; Tetsuya Taga; Hiroshi Kiyama
Characteristic localization of gp130 (the signal-transducing receptor component used in common for IL-6/IL-11/CNTF/LIF/OSM) in the rat brain.
The European journal of neuroscience 1996;8(8):1630-40.
1996: W Shi; M Inoue; M Minami; K Takeda; M Matsumoto; Y Matsuda; Tadamitsu Kishimoto; S Akira
The genomic structure and chromosomal localization of the mouse STAT3 gene.
International immunology 1996;8(8):1205-11.
1996: Shouji Hashimoto; Satoshi Tsukada; M Matsushita; Toshio Miyawaki; Yo Niida; Akihiro Yachie; S Kobayashi; T Iwata; H Hayakawa; H Matsuoka; I Tsuge; Tomoki Yamadori; T Kunikata; S Arai; Kazuyuki Yoshizaki; Naoyuki Taniguchi; Tadamitsu Kishimoto
Identification of Bruton's tyrosine kinase (Btk) gene mutations and characterization of the derived proteins in 35 X-linked agammaglobulinemia families: a nationwide study of Btk deficiency in Japan.
Blood 1996;88(2):561-73.
1996: Keiko Yamauchi-Takihara; C Nakajima-Taniguchi; H Matsui; Yasushi Fujio; Keita Kunisada; Seiki Nagata; Tadamitsu Kishimoto
Clinical implications of hypertrophic cardiomyopathy associated with mutations in the alpha-tropomyosin gene.
Heart (British Cardiac Society) 1996;76(1):63-5.
1996: T Yamamoto; K Ozono; Soji Kasayama; K Yoh; K Hiroshima; M Takagi; S Matsumoto; Toshimi Michigami; K Yamaoka; Tadamitsu Kishimoto; Shintaro Okada
Increased IL-6-production by cells isolated from the fibrous bone dysplasia tissues in patients with McCune-Albright syndrome.
The Journal of clinical investigation 1996;98(1):30-5.
1996: Hisao Hirota; Hiroshi Kiyama; Tadamitsu Kishimoto; Tetsuya Taga
Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma.
The Journal of experimental medicine 1996;183(6):2627-34.
1996: Hisao Hirota; Kanji Yoshida; Tetsuya Taga; Tadamitsu Kishimoto
gp130 signaling pathways: Recent advances and implications for cardiovascular disease.
Trends in cardiovascular medicine 1996;6(4):109-15.
1996: M Minami; M Inoue; S Wei; K Takeda; M Matsumoto; Tadamitsu Kishimoto; S Akira
STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):3963-6.
1996: K Takeda; T Tanaka; W Shi; M Matsumoto; M Minami; S Kashiwamura; Kenji Nakanishi; N Yoshida; Tadamitsu Kishimoto; S Akira
Essential role of Stat6 in IL-4 signalling.
Nature 1996;380(6575):627-30.
1996: S Takeshita; J R Gage; Tadamitsu Kishimoto; Donna L Vredevoe; Otoniel Martínez-Maza
Differential regulation of IL-6 gene transcription and expression by IL-4 and IL-10 in human monocytic cell lines.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(7):2591-8.
1996: T Sugiyama; Y Nishio; Tadamitsu Kishimoto; S Akira
Identification of alternative splicing form of Stat2.
FEBS letters 1996;381(3):191-4.
1996: Haruo Sugiyama; K Inoue; Hiroyasu Ogawa; Tamotsu Yamagami; Toshihiro Soma; S Miyake; M Hirata; Tadamitsu Kishimoto
The expression of IL-6 and its related genes in acute leukemia.
Leukemia & lymphoma 1996;21(1-2):49-52.
1996: M Kamanaka; P Yu; T Yasui; K Yoshida; T Kawabe; T Horii; Tadamitsu Kishimoto; Hitoshi Kikutani
Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity.
Immunity 1996;4(3):275-81.
1996: H Ochi; T Tanaka; Yoshinori Katada; T Naka; M Aitani; S Hashimoto; K Maeda; K Toyoshima; T Igarashi; Masaki Suemura; Tadamitsu Kishimoto
Functional disturbance of naive T lymphocytes in very high IgE producers: depletion of interleukin-4-induced interleukin-4-producing cells.
International archives of allergy and immunology 1996;109(3):236-42.
1996: T Kumagai; Y Tanio; Tadashi Osaki; S Hosoe; Isao Tachibana; K Ueno; T Kijima; T Horai; Tadamitsu Kishimoto
Eradication of Myc-overexpressing small cell lung cancer cells transfected with herpes simplex virus thymidine kinase gene containing Myc-Max response elements.
Cancer research 1996;56(2):354-8.
1996: Kanji Yoshida; Tetsuya Taga; M Saito; Sachiko Suematsu; A Kumanogoh; T Tanaka; Hiromi Fujiwara; M Hirata; T Yamagami; T Nakahata; T Hirabayashi; Yoshihiro Yoneda; K Tanaka; W Z Wang; C Mori; K Shiota; N Yoshida; Tadamitsu Kishimoto
Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):407-11.
1996: S Akira; Tadamitsu Kishimoto
Role of interleukin-6 in macrophage function.
Current opinion in hematology 1996;3(1):87-93.
1996: T Yasui; Hiromi Fujiwara; M Kamanaka; T Kawabe; N Yoshida; Tadamitsu Kishimoto; Hitoshi Kikutani
The roles of CD40 and CD23 in IgE regulation.
Advances in experimental medicine and biology 1996;409():349-54.
1996: Yoshinori Katada; T Tanaka; H Ochi; M Aitani; A Yokota; Hitoshi Kikutani; Masaki Suemura; Tadamitsu Kishimoto
B cell-B cell interaction through intercellular adhesion molecule-1 and lymphocyte functional antigen-1 regulates immunoglobulin E synthesis by B cells stimulated with interleukin-4 and anti-CD40 antibody.
European journal of immunology 1996;26(1):192-200.
1995: C Nakajima-Taniguchi; H Matsui; N Eguchi; Seiki Nagata; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara
A novel deletion mutation in the beta-myosin heavy chain gene found in Japanese patients with hypertrophic cardiomyopathy.
Journal of molecular and cellular cardiology 1995;27(12):2607-12.
1995: S Akira; Kanji Yoshida; T Tanaka; Tetsuya Taga; Tadamitsu Kishimoto
Targeted disruption of the IL-6 related genes: gp130 and NF-IL-6.
Immunological reviews 1995;148():221-53.
1995: C Nakajima-Taniguchi; Junichi Azuma; Seiki Nagata; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara
A missense mutation in the beta-myosin heavy chain gene in a Japanese patient with hypertrophic cardiomyopathy.
Japanese circulation journal 1995;59(12):833-7.
1995: A Yokota; N Murata; O Saiki; Masahiko Shimizu; T A Springer; Tadamitsu Kishimoto
High avidity state of leukocyte function-associated antigen-1 on rheumatoid synovial fluid T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(8):4118-24.
1995: S Takeshita; Elizabeth Crabb Breen; M Ivashchenko; P Nishanian; Tadamitsu Kishimoto; Donna L Vredevoe; Otoniel Martinez-Maza
Induction of IL-6 and IL-10 production by recombinant HIV-1 envelope glycoprotein 41 (gp41) in the THP-1 human monocytic cell line.
Cellular immunology 1995;165(2):234-42.
1995: T Mima; Y Saeki; S Ohshima; N Nishimoto; M Matsushita; M Shimizu; Y Kobayashi; T Nomura; Tadamitsu Kishimoto
Transfer of rheumatoid arthritis into severe combined immunodeficient mice. The pathogenetic implications of T cell populations oligoclonally expanding in the rheumatoid joints.
The Journal of clinical investigation 1995;96(4):1746-58.
1995: K Hashimoto; M Koga; T Motomura; Soji Kasayama; H Kouhara; T Ohnishi; Norio Arita; T Hayakawa; B Sato; Tadamitsu Kishimoto
Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas.
The Journal of clinical endocrinology and metabolism 1995;80(10):2933-9.
1995: Tadamitsu Kishimoto; T Tanaka; Kanji Yoshida; S Akira; Tetsuya Taga
Cytokine signal transduction through a homo- or heterodimer of gp130.
Annals of the New York Academy of Sciences 1995;766():224-34.
1995: C Nakajima-Taniguchi; H Matsui; Seiki Nagata; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara
Novel missense mutation in alpha-tropomyosin gene found in Japanese patients with hypertrophic cardiomyopathy.
Journal of molecular and cellular cardiology 1995;27(9):2053-8.
1995: Tadamitsu Kishimoto; S Akira; Michiko Narazaki; Tetsuya Taga
Interleukin-6 family of cytokines and gp130.
Blood 1995;86(4):1243-54.
1995: M Liu; Otoniel Martinez-Maza; M T Johnson; J Fan; Tadamitsu Kishimoto; Susan F Plaeger
IL-6 induces target cell resistance to HIV-specific cytotoxic lysis.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1995;9(4):321-31.
1995: Masaaki Yamaguchi; Tetsuya Taga; Tadamitsu Kishimoto; A Miyake
Cytokines that use gp130 as a signal transducer stimulate mouse placental lactogen-I (mPL-I) but inhibit mPL-II production in vitro.
Biology of reproduction 1995;53(2):399-406.
1995: S Akira; Y Nishio; T Tanaka; M Inoue; T Matsusaka; X J Wang; S Wei; N Yoshida; Tadamitsu Kishimoto
Transcription factors NF-IL6 and APRF involved in gp130-mediated signaling pathway.
Annals of the New York Academy of Sciences 1995;762():15-27; discussion 27-8.
1995: Masaaki Yamaguchi; A Mammoto; Tetsuya Taga; Tadamitsu Kishimoto; A Miyake
Regulation of mouse soluble interleukin-6 receptor secretion by decidua.
Biochemical and biophysical research communications 1995;211(3):1077-82.
1995: H Kouhara; Shogo Kurebayashi; K Hashimoto; Soji Kasayama; M Koga; Tadamitsu Kishimoto; B Sato
Ligand-independent activation of tyrosine kinase in fibroblast growth factor receptor 1 by fusion with beta-galactosidase.
Oncogene 1995;10(12):2315-22.
1995: Hisao Hirota; Kanji Yoshida; Tadamitsu Kishimoto; Tetsuya Taga
Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):4862-6.
1995: Y Oka; Antonius G Rolink; S Suematsu; Tadamitsu Kishimoto; Fritz Melchers
An interleukin-6 transgene expressed in B lymphocyte lineage cells overcomes the T cell-dependent establishment of normal levels of switched immunoglobulin isotypes.
European journal of immunology 1995;25(5):1332-7.
1995: K Sawai; Nobue Matsuzaki; T Kameda; K Hashimoto; T Okada; Koichiro Shimoya; Toshikatsu Nobunaga; Tetsuya Taga; Tadamitsu Kishimoto; Fumitaka Saji
Leukemia inhibitory factor produced at the fetomaternal interface stimulates chorionic gonadotropin production: its possible implication during pregnancy, including implantation period.
The Journal of clinical endocrinology and metabolism 1995;80(4):1449-56.
1995: Masaaki Yamaguchi; Naomasa Miki; M Ono; C Ohtsuka; H Demura; Hirohisa Kurachi; M Inoue; H Endo; Tetsuya Taga; Tadamitsu Kishimoto
Inhibition of growth hormone-releasing factor production in mouse placenta by cytokines using gp130 as a signal transducer.
Endocrinology 1995;136(3):1072-8.
1995: Keiko Yamauchi-Takihara; Y Ihara; A Ogata; K Yoshizaki; Junichi Azuma; Tadamitsu Kishimoto
Hypoxic stress induces cardiac myocyte-derived interleukin-6.
Circulation 1995;91(5):1520-4.
1995: Tetsuya Taga; Tadamitsu Kishimoto
Signaling mechanisms through cytokine receptors that share signal transducing receptor components.
Current opinion in immunology 1995;7(1):17-23.
1995: Y Shima; Norihiro Nishimoto; A Ogata; Y Fujii; Kazuyuki Yoshizaki; Tadamitsu Kishimoto
Myeloma cells express Fas antigen/APO-1 (CD95) but only some are sensitive to anti-Fas antibody resulting in apoptosis.
Blood 1995;85(3):757-64.
1995: T Tanaka; S Akira; Kanji Yoshida; M Umemoto; Yoshihiro Yoneda; N Shirafuji; H Fujiwara; Sachiko Suematsu; N Yoshida; Tadamitsu Kishimoto
Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages.
Cell 1995;80(2):353-61.
1995: Y Tani; Norihiro Nishimoto; A Ogata; Y Shima; Kazuyuki Yoshizaki; Tadamitsu Kishimoto
Gp130 in human myeloma/plasmacytoma.
Current topics in microbiology and immunology 1995;194():229-33.
1995: M Nakagawa; H Sugiyama; H Ogawa; S Tone; H Morishita; H Ikeda; Katsuyuki Aozasa; M Taniwaki; T Abe; Tadamitsu Kishimoto
Intermediate lymphocytic lymphoma with both t(14;19)(q32.3;q13.1) and t(3;22)(q27;q11.2).
Cancer genetics and cytogenetics 1995;79(1):89-91.
1994: Y Yamamoto; R Mizuno; Tsunehiko Nishimura; Y Ogawa; Hideki Yoshikawa; Harutoshi Fujimura; E Adachi; Tadamitsu Kishimoto; Takehiko Yanagihara; Saburo Sakoda
Cloning and expression of myelin-associated oligodendrocytic basic protein. A novel basic protein constituting the central nervous system myelin.
The Journal of biological chemistry 1994;269(50):31725-30.
1994: Soji Kasayama; M Koga; H Kouhara; S Sumitani; K Wada; Tadamitsu Kishimoto; B Sato
Unsaturated fatty acids are required for continuous proliferation of transformed androgen-dependent cells by fibroblast growth factor family proteins.
Cancer research 1994;54(24):6441-5.
1994: Takashi Maeda; Masaaki Yamaguchi; Tetsuya Taga; Tadamitsu Kishimoto; K Wada; Hiroshi Ikegami; Hirohisa Kurachi; A Miyake
Decidua is a possible source of serum mouse soluble interleukin-6 receptor (msIL-6R): gestational profile of serum msIL-6R concentration.
Biochemical and biophysical research communications 1994;205(2):998-1003.
1994: Tasuku Harada; H Saito; H Kouhara; Shogo Kurebayashi; Soji Kasayama; Naoki Terakawa; Tadamitsu Kishimoto; B Sato
Murine fibroblast growth factor receptor 1 gene generates multiple messenger RNAs containing two open reading frames via alternative splicing.
Biochemical and biophysical research communications 1994;205(2):1057-63.
1994: Y Shimizu; H Ogawa; Y Oka; R Mizuno; Saburo Sakoda; Tadamitsu Kishimoto; Haruo Sugiyama
Isolation of a cDNA clone encoding a novel membrane protein expressed in lymphocytes.
FEBS letters 1994;355(1):30-4.
1994: A Ogata; Norihiro Nishimoto; Y Shima; Kazuyuki Yoshizaki; Tadamitsu Kishimoto
Inhibitory effect of all-trans retinoic acid on the growth of freshly isolated myeloma cells via interference with interleukin-6 signal transduction.
Blood 1994;84(9):3040-6.
1994: Y Miyashita; M Koga; H Kouhara; A Tanaka; Tadamitsu Kishimoto; B Sato
Facilitation of autonomous phenotype acquisition in androgen-dependent Shionogi carcinoma 115 cells by transfection of androgen-induced growth factor expression vector.
Japanese journal of cancer research : Gann 1994;85(11):1117-23.
1994: Tadashi Osaki; Y Tanio; Isao Tachibana; S Hosoe; T Kumagai; I Kawase; S Oikawa; Tadamitsu Kishimoto
Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene.
Cancer research 1994;54(20):5258-61.
1994: H Nakamura; Y Izumoto; H Kambe; T Kuroda; T Mori; K Kawamura; H Yamamoto; Tadamitsu Kishimoto
Molecular cloning of complementary DNA for a novel human hepatoma-derived growth factor. Its homology with high mobility group-1 protein.
The Journal of biological chemistry 1994;269(40):25143-9.
1994: Daniel P Widney; S Yawetz; M van der Meyden; Steven A Miles; Tadamitsu Kishimoto; Otoniel Martínez-Maza
Effects of zidovudine on B lymphocyte activation.
Cellular immunology 1994;158(1):140-56.
1994: K Hashimoto; M Koga; H Kouhara; Norio Arita; T Hayakawa; Tadamitsu Kishimoto; B Sato
Expression patterns of messenger ribonucleic acids encoding prohormone convertases (PC2 and PC3) in human pituitary adenomas.
Clinical endocrinology 1994;41(2):185-91.
1994: A Kumanogoh; Soji Kasayama; H Kouhara; M Koga; Norio Arita; T Hayakawa; Tadamitsu Kishimoto; B Sato
Effects of therapy on anterior pituitary functions in patients with primary intracranial germ cell tumor.
Endocrine journal 1994;41(3):287-92.
1994: T Kawabe; T Naka; K Yoshida; T Tanaka; Hiromi Fujiwara; Sachiko Suematsu; N Yoshida; Tadamitsu Kishimoto; Hitoshi Kikutani
The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation.
Immunity 1994;1(3):167-78.
1994: S Akira; Y Nishio; M Inoue; X J Wang; S Wei; T Matsusaka; Kanji Yoshida; T Sudo; M Naruto; Tadamitsu Kishimoto
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway.
Cell 1994;77(1):63-71.
1994: Norihiro Nishimoto; A Ogata; Y Shima; Y Tani; H Ogawa; M Nakagawa; H Sugiyama; Kazuyuki Yoshizaki; Tadamitsu Kishimoto
Oncostatin M, leukemia inhibitory factor, and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer, gp130.
The Journal of experimental medicine 1994;179(4):1343-7.
1994: S Hosoe; K Ueno; Y Shigedo; Isao Tachibana; Tadashi Osaki; T Kumagai; Y Tanio; I Kawase; Y Nakamura; Tadamitsu Kishimoto
A frequent deletion of chromosome 5q21 in advanced small cell and non-small cell carcinoma of the lung.
Cancer research 1994;54(7):1787-90.
1994: T Nagasawa; Tsuneyasu Kaisho; Tadamitsu Kishimoto; Hitoshi Kikutani
Generation and characterization of a monoclonal antibody that inhibits stromal cell-dependent B lymphopoiesis.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(6):2788-97.
1994: T Nagasawa; Hitoshi Kikutani; Tadamitsu Kishimoto
Molecular cloning and structure of a pre-B-cell growth-stimulating factor.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(6):2305-9.
1994: Michiko Narazaki; bruce witthuhn; Kanji Yoshida; O Silvennoinen; K Yasukawa; James N Ihle; Tadamitsu Kishimoto; Tetsuya Taga
Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(6):2285-9.
1994: S Saito; Y Tanio; Isao Tachibana; Seiji Hayashi; Tadamitsu Kishimoto; I Kawase
Complementary DNA sequence encoding the major neural cell adhesion molecule isoform in a human small cell lung cancer cell line.
Lung cancer (Amsterdam, Netherlands) 1994;10(5-6):307-18.
1994: S Hosoe; Y Shigedo; K Ueno; Isao Tachibana; Tadashi Osaki; Y Tanio; I Kawase; K Yamakawa; Y Nakamura; Tadamitsu Kishimoto
Detailed deletion mapping of the short arm of chromosome 3 in small cell and non-small cell carcinoma of the lung.
Lung cancer (Amsterdam, Netherlands) 1994;10(5-6):297-305.
1994: H Saito; H Kouhara; T Harada; S Miyake; H Sugiyama; Tadamitsu Kishimoto; B Sato
Mapping of a transcription element critical for expression of the fibroblast growth factor receptor 1 gene.
Biochemical and biophysical research communications 1994;198(3):1020-6.
1994: H Kouhara; M Koga; Soji Kasayama; A Tanaka; Tadamitsu Kishimoto; B Sato
Transforming activity of a newly cloned androgen-induced growth factor.
Oncogene 1994;9(2):455-62.
1994: Kanji Yoshida; Ian Chambers; Jennifer Nichols; Austin Smith; M Saito; K Yasukawa; M Shoyab; Tetsuya Taga; Tadamitsu Kishimoto
Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways.
Mechanisms of development 1994;45(2):163-71.
1994: Tadamitsu Kishimoto; Tetsuya Taga; S Akira
Cytokine signal transduction.
Cell 1994;76(2):253-62.
1994: Tadamitsu Kishimoto
Signal transduction through homo- or heterodimers of gp130.
Stem cells (Dayton, Ohio) 1994;12 Suppl 1():37-44; discussion 44-5.
1993: Hiroki Ohzato; Morito Monden; Kazuyuki Yoshizaki; A Ogata; Norihiro Nishimoto; M Gotoh; Tadamitsu Kishimoto; T Mori
Systemic production of interleukin-6 following acute inflammation.
Biochemical and biophysical research communications 1993;197(3):1556-62.
1993: B Sato; H Kouhara; M Koga; Soji Kasayama; H Saito; S Sumitani; K Hashimoto; Tadamitsu Kishimoto; A Tanaka; K Matsumoto
Androgen-induced growth factor and its receptor: demonstration of the androgen-induced autocrine loop in mouse mammary carcinoma cells.
The Journal of steroid biochemistry and molecular biology 1993;47(1-6):91-8.
1993: K Yukawa; T Yasui; A Yamamoto; H Shiku; Tadamitsu Kishimoto; Hitoshi Kikutani
Epoc-1: a POU-domain gene expressed in murine epidermal basal cells and thymic stromal cells.
Gene 1993;133(2):163-9.
1993: T Matsusaka; K Fujikawa; Y Nishio; N Mukaida; K Matsushima; Tadamitsu Kishimoto; S Akira
Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):10193-7.
1993: Michiko Narazaki; K Yasukawa; T Saito; Yoshiyuki Ohsugi; H Fukui; Y Koishihara; G D Yancopoulos; Tetsuya Taga; Tadamitsu Kishimoto
Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130.
Blood 1993;82(4):1120-6.
1993: T Saito; Tetsuya Taga; D Miki; K Futatsugi; H Yawata; Tadamitsu Kishimoto; K Yasukawa
Preparation of monoclonal antibodies against the IL-6 signal transducer, gp130, that can inhibit IL-6-mediated functions.
Journal of immunological methods 1993;163(2):217-23.
1993: Tadamitsu Kishimoto
[Diseases associated with cytokine dysregulation].
Nihon Sanka Fujinka Gakkai zasshi 1993;45(8):724-34.
1993: M Murakami; Masahiko Hibi; N Nakagawa; T Nakagawa; K Yasukawa; K Yamanishi; Tetsuya Taga; Tadamitsu Kishimoto
IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase.
Science (New York, N.Y.) 1993;260(5115):1808-10.
1993: H Suzuki; K Yasukawa; T Saito; Michiko Narazaki; A Hasegawa; Tetsuya Taga; Tadamitsu Kishimoto
Serum soluble interleukin-6 receptor in MRL/lpr mice is elevated with age and mediates the interleukin-6 signal.
European journal of immunology 1993;23(5):1078-82.
1993: Neil stahl; S Davis; V Wong; Tetsuya Taga; Tadamitsu Kishimoto; N Y Ip; George D Yancopoulos
Cross-linking identifies leukemia inhibitory factor-binding protein as a ciliary neurotrophic factor receptor component.
The Journal of biological chemistry 1993;268(11):7628-31.
1993: H Yawata; K Yasukawa; Shunji Natsuka; M Murakami; K Yamasaki; Masahiko Hibi; Tetsuya Taga; Tadamitsu Kishimoto
Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130.
The EMBO journal 1993;12(4):1705-12.
1993: T Nakajima; Shigeru Kinoshita; T Sasagawa; K Sasaki; M Naruto; Tadamitsu Kishimoto; S Akira
Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(6):2207-11.
1993: Y Nishio; H Isshiki; Tadamitsu Kishimoto; S Akira
A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat alpha 1-acid glycoprotein gene via direct protein-protein interaction.
Molecular and cellular biology 1993;13(3):1854-62.
1993: Sachiko Suematsu; T Matsusaka; Toshio Matsuda; Toshio Hirano; Tadamitsu Kishimoto
Interleukin-6 in myeloma/plasmacytoma.
International review of experimental pathology 1993;34 Pt A():91-8.
1993: S Akira; Tetsuya Taga; Tadamitsu Kishimoto
Interleukin-6 in biology and medicine.
Advances in immunology 1993;54():1-78.
1992: I Kobayashi; Toshio Matsuda; T Saito; K Yasukawa; Hitoshi Kikutani; Toshio Hirano; Tetsuya Taga; Tadamitsu Kishimoto
Abnormal distribution of IL-6 receptor in aged MRL/lpr mice: elevated expression on B cells and absence on CD4+ cells.
International immunology 1992;4(12):1407-12.
1992: Tetsuya Taga; Michiko Narazaki; K Yasukawa; T Saito; D Miki; M Hamaguchi; S Davis; M Shoyab; G D Yancopoulos; Tadamitsu Kishimoto
Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10998-1001.
1992: Tadamitsu Kishimoto; S Akira; Tetsuya Taga
Interleukin-6 and its receptor: a paradigm for cytokines.
Science (New York, N.Y.) 1992;258(5082):593-7.
1992: Y Nakatsuji; K Hidaka; S Tsujino; Y Yamamoto; T Mukai; T Yanagihara; Tadamitsu Kishimoto; S Sakoda
A single MEF-2 site is a major positive regulatory element required for transcription of the muscle-specific subunit of the human phosphoglycerate mutase gene in skeletal and cardiac muscle cells.
Molecular and cellular biology 1992;12(10):4384-90.
1992: Jeffrey B. Smith; R D Kunjummen; Tadamitsu Kishimoto; D C Anderson
Expression and regulation of L-selectin on eosinophils from human adults and neonates.
Pediatric research 1992;32(4):465-71.
1992: Toshio Hirano; Tadamitsu Kishimoto
Molecular biology and immunology of interleukin-6.
Research in immunology 1992;143(7):723-4.
1992: H Suzuki; K Yasukawa; T Saito; R Goitsuka; A Hasegawa; Y Ohsugi; Tetsuya Taga; Tadamitsu Kishimoto
Anti-human interleukin-6 receptor antibody inhibits human myeloma growth in vivo.
European journal of immunology 1992;22(8):1989-93.
1992: Atsushi Muraguchi; N Kawamura; A Hori; Y Horii; Y Ichigi; Masao Kimoto; Tadamitsu Kishimoto
Expression of the CD2 molecule on human B lymphoid progenitors.
International immunology 1992;4(8):841-9.
1992: Yukihiko Saeki; Toru Mima; S Sakoda; H Fujimura; N Arita; T Nomura; Tadamitsu Kishimoto
Transfer of multiple sclerosis into severe combined immunodeficiency mice by mononuclear cells from cerebrospinal fluid of the patients.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):6157-61.
1992: M Saito; Kanji Yoshida; Masahiko Hibi; Tetsuya Taga; Tadamitsu Kishimoto
Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(12):4066-71.
1992: Kazuyuki Yoshizaki; T Kuritani; Tadamitsu Kishimoto
Interleukin-6 in autoimmune disorders.
Seminars in immunology 1992;4(3):155-66.
1992: Y Shimizu; Yoshihiro Oka; H Ogawa; Tadamitsu Kishimoto; H Sugiyama
Regulation of Thy-1 gene expression by the methylation of the 5' region of Thy-1 gene and intracellular regulatory factors in immature B cells.
Immunological investigations 1992;21(3):183-91.
1992: A Yokota; K Yukawa; A Yamamoto; K Sugiyama; Masaki Suemura; Y Tashiro; Tadamitsu Kishimoto; Hitoshi Kikutani
Two forms of the low-affinity Fc receptor for IgE differentially mediate endocytosis and phagocytosis: identification of the critical cytoplasmic domains.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(11):5030-4.
1992: S Akira; Tadamitsu Kishimoto
Mechanisms of soluble mediators.
Current opinion in immunology 1992;4(3):307-13.
1992: S Akira; Tadamitsu Kishimoto
IL-6 and NF-IL6 in acute-phase response and viral infection.
Immunological reviews 1992;127():25-50.
1992: Tadatsugu Taniguchi; Nobue Matsuzaki; T Jo; Fumitaka Saji; Tetsuya Taga; Toshio Hirano; Tadamitsu Kishimoto; O Tanizawa
Interleukin-1 (IL-1)-induced IL-6- and IL-6-receptor-mediated release of human chorionic gonadotropin by choriocarcinoma cell lines (Jar and HCCM-5) activates adenosine 3',5'-monophosphate-independent signal transduction pathway.
The Journal of clinical endocrinology and metabolism 1992;74(6):1389-95.
1992: Hiroaki Ito; H Kambe; Y Kimura; H Nakamura; E Hayashi; Tadamitsu Kishimoto; S Kishimoto; H Yamamoto
Depression of plasma gelsolin level during acute liver injury.
Gastroenterology 1992;102(5):1686-92.
1992: A Ogata; H Tagoh; T Lee; T Kuritani; Y Takahara; T Shimamura; H Ikegami; M Kurimoto; Kazuyuki Yoshizaki; Tadamitsu Kishimoto
A new highly sensitive immunoassay for cytokines by dissociation-enhanced lanthanide fluoroimmunoassay (DELFIA).
Journal of immunological methods 1992;148(1-2):15-22.
1992: Tadamitsu Kishimoto; S Akira; Tetsuya Taga
IL-6 receptor and mechanism of signal transduction.
International journal of immunopharmacology 1992;14(3):431-8.
1992: Tadamitsu Kishimoto
Interleukin-6 and its receptor in autoimmunity.
Journal of autoimmunity 1992;5 Suppl A():123-32.
1992: H Saito; H Kouhara; Soji Kasayama; Tadamitsu Kishimoto; B Sato
Characterization of the promoter region of the murine fibroblast growth factor receptor 1 gene.
Biochemical and biophysical research communications 1992;183(2):688-93.
1992: Steven A Miles; Otoniel Martínez-Maza; Ali R Rezai; L Magpantay; Tadamitsu Kishimoto; S Nakamura; S F Radka; Peter Linsley
Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells.
Science (New York, N.Y.) 1992;255(5050):1432-4.
1992: Shigeru Kinoshita; S Akira; Tadamitsu Kishimoto
A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1473-6.
1992: Tsuneyasu Kaisho; T Nagasawa; Tadamitsu Kishimoto; Hitoshi Kikutani
A stromal cell-specific monoclonal antibody augments the stromal cell-dependent B lymphopoiesis.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(4):989-95.
1992: K Yasukawa; K Futatsugi; T Saito; H Yawata; Michiko Narazaki; H Suzuki; Tetsuya Taga; Tadamitsu Kishimoto
Association of recombinant soluble IL-6-signal transducer, gp130, with a complex of IL 6 and soluble IL-6 receptor, and establishment of an ELISA for soluble gp130.
Immunology letters 1992;31(2):123-30.
1992: Hiroki Ohzato; Kazuyuki Yoshizaki; Norihiro Nishimoto; A Ogata; H Tagoh; Morito Monden; M Gotoh; Tadamitsu Kishimoto; T Mori
Interleukin-6 as a new indicator of inflammatory status: detection of serum levels of interleukin-6 and C-reactive protein after surgery.
Surgery 1992;111(2):201-9.
1992: S Akira; Tadamitsu Kishimoto
The evidence for interleukin-6 as an autocrine growth factor in malignancy.
Seminars in cancer biology 1992;3(1):17-26.
1992: M Aitani; Masaki Suemura; Tadamitsu Kishimoto
[Immunologically mediated bronchial asthma].
Kokyu to junkan. Respiration & circulation 1992;40(2):108-11.
1992: Y Yamamoto; H Kawai; K Nakahara; M Osame; Y Nakatsuji; Tadamitsu Kishimoto; Saburo Sakoda
A novel primer extension method to detect the number of CAG repeats in the androgen receptor gene in families with X-linked spinal and bulbar muscular atrophy.
Biochemical and biophysical research communications 1992;182(2):507-13.
1992: Shunji Natsuka; S Akira; Y Nishio; Shouji Hashimoto; T Sugita; H Isshiki; Tadamitsu Kishimoto
Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6.
Blood 1992;79(2):460-6.
1992: Sachiko Suematsu; T Matsusaka; Toshio Matsuda; S Ohno; J Miyazaki; K Yamamura; Toshio Hirano; Tadamitsu Kishimoto
Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(1):232-5.
1992: Tetsuya Taga; Tadamitsu Kishimoto
Role of a two-chain IL-6 receptor system in immune and hematopoietic cell regulation.
Critical reviews in immunology 1992;11(5):265-80.
1992: S Akira; H Isshiki; T Nakajima; Shigeru Kinoshita; Y Nishio; Shouji Hashimoto; Shunji Natsuka; Tadamitsu Kishimoto
A nuclear factor for the IL-6 gene (NF-IL6).
Chemical immunology 1992;51():299-322.
1992: Tadamitsu Kishimoto; Masahiko Hibi; M Murakami; Michiko Narazaki; M Saito; Tetsuya Taga
The molecular biology of interleukin 6 and its receptor.
Ciba Foundation symposium 1992;167():5-16; discussion 16-23.
1992: Toshio Hirano; Sachiko Suematsu; T Matsusaka; Toshio Matsuda; Tadamitsu Kishimoto
The role of interleukin 6 in plasmacytomagenesis.
Ciba Foundation symposium 1992;167():188-96; discussion 196-200.
1992: S Akira; H Isshiki; T Nakajima; Shigeru Kinoshita; Y Nishio; Shunji Natsuka; Tadamitsu Kishimoto
Regulation of expression of the interleukin 6 gene: structure and function of the transcription factor NF-IL6.
Ciba Foundation symposium 1992;167():47-62; discussion 62-7.
1991: M Murakami; Michiko Narazaki; Masahiko Hibi; H Yawata; K Yasukawa; M Hamaguchi; Tetsuya Taga; Tadamitsu Kishimoto
Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11349-53.
1991: Shunji Natsuka; H Isshiki; S Akira; Tadamitsu Kishimoto
Augmentation of haptoglobin production in Hep3B cell line by a nuclear factor NF-IL6.
FEBS letters 1991;291(1):58-62.
1991: H Suzuki; K Yasukawa; T Saito; M Anzai; R Goitsuka; A Hasegawa; Y Ohsugi; Tetsuya Taga; Tadamitsu Kishimoto
Anti-murine IL-6 receptor antibody inhibits IL-6 effects in vivo.
Immunology letters 1991;30(1):17-21.
1991: N Sidell; T Taga; Toshio Hirano; Tadamitsu Kishimoto; Andrew Saxon
Retinoic acid-induced growth inhibition of a human myeloma cell line via down-regulation of IL-6 receptors.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(11):3809-14.
1991: N Nakano; Hitoshi Kikutani; H Nishimoto; Tadamitsu Kishimoto
T cell receptor V gene usage of islet beta cell-reactive T cells is not restricted in non-obese diabetic mice.
The Journal of experimental medicine 1991;173(5):1091-7.
1991: Masaki Suemura; Hitoshi Kikutani; K Sugiyama; N Uchibayashi; M Aitani; T Kuritani; E L Barsumian; Atsushi Yamatodani; Tadamitsu Kishimoto
Significance of soluble Fc epsilon receptor II (sFc epsilon RII/CD23) in serum and possible application of sFc epsilon RII for the prevention of allergic reactions.
Allergy proceedings : the official journal of regional and state allergy societies 1991;12(3):133-7.
1991: B Tang; Toshio Matsuda; S Akira; N Nagata; S Ikehara; Toshio Hirano; Tadamitsu Kishimoto
Age-associated increase in interleukin 6 in MRL/lpr mice.
International immunology 1991;3(3):273-8.
1991: H Isshiki; S Akira; T Sugita; Y Nishio; Shouji Hashimoto; T Pawlowski; Sachiko Suematsu; Tadamitsu Kishimoto
Reciprocal expression of NF-IL6 and C/EBP in hepatocytes: possible involvement of NF-IL6 in acute phase protein gene expression.
The New biologist 1991;3(1):63-70.
1990: Masahiko Hibi; M Murakami; M Saito; Toshio Hirano; Tetsuya Taga; Tadamitsu Kishimoto
Molecular cloning and expression of an IL-6 signal transducer, gp130.
Cell 1990;63(6):1149-57.
1990: Toshio Hirano; S Akira; Tetsuya Taga; Tadamitsu Kishimoto
Biological and clinical aspects of interleukin 6.
Immunology today 1990;11(12):443-9.
1990: S Inui; Tsuneyasu Kaisho; Hitoshi Kikutani; I Stamenkovic; B Seed; E A Clark; Tadamitsu Kishimoto
Identification of the intracytoplasmic region essential for signal transduction through a B cell activation molecule, CD40.
European journal of immunology 1990;20(8):1747-53.
1990: Norihiro Nishimoto; Kazuyuki Yoshizaki; Nobutaka Eiraku; K Machigashira; H Tagoh; A Ogata; T Kuritani; Mitsuhiro Osame; Tadamitsu Kishimoto
Elevated levels of interleukin-6 in serum and cerebrospinal fluid of HTLV-I-associated myelopathy/tropical spastic paraparesis.
Journal of the neurological sciences 1990;97(2-3):183-93.
1990: T Miyazaki; M Uno; Masahiro Uehira; H Kikutani; Tadamitsu Kishimoto; M Kimoto; H Nishimoto; J Miyazaki; Ken-ichi Yamamura
Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice.
Nature 1990;345(6277):722-4.
1990: T Sugita; T Totsuka; M Saito; K Yamasaki; Tetsuya Taga; Toshio Hirano; Tadamitsu Kishimoto
Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis.
The Journal of experimental medicine 1990;171(6):2001-9.
1990: S Akira; H Isshiki; T Sugita; O Tanabe; Shigeru Kinoshita; Y Nishio; T Nakajima; Toshio Hirano; Tadamitsu Kishimoto
A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.
The EMBO journal 1990;9(6):1897-906.
1990: H Isshiki; S Akira; O Tanabe; T Nakajima; T Shimamoto; Toshio Hirano; Tadamitsu Kishimoto
Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene.
Molecular and cellular biology 1990;10(6):2757-64.
1990: T Taga; Tadamitsu Kishimoto
Immune and hematopoietic cell regulation: cytokines and their receptors.
Current opinion in cell biology 1990;2(2):174-80.
1990: Hitoshi Kikutani; Tadamitsu Kishimoto
Molecular genetics and biology of two different species of Fc epsilon RII.
Research in immunology 1990;141(3):249-58.
1990: Elizabeth Crabb Breen; Ali R Rezai; K Nakajima; G N Beall; Ronald T Mitsuyasu; Toshio Hirano; Tadamitsu Kishimoto; Otoniel Martinez-Maza
Infection with HIV is associated with elevated IL-6 levels and production.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(2):480-4.
1990: Toshio Hirano; Tetsuya Taga; Toshio Matsuda; Masahiko Hibi; Sachiko Suematsu; B Tang; M Murakami; Tadamitsu Kishimoto
Interleukin 6 and its receptor in the immune response and hematopoiesis.
International journal of cell cloning 1990;8 Suppl 1():155-66; discussion 166-7.
1990: Sachiko Suematsu; Masahiko Hibi; T Sugita; M Saito; M Murakami; T Matsusaka; Toshio Matsuda; Toshio Hirano; Tetsuya Taga; Tadamitsu Kishimoto
Interleukin 6 (IL-6) and its receptor (IL-6R) in myeloma/plasmacytoma.
Current topics in microbiology and immunology 1990;166():13-22.
1990: N Nakano; H Kikutani; Tadamitsu Kishimoto
Differential effects of IL-2 and IL-6 on the development of three distinct precursor T-cell populations in the thymus.
Developmental immunology 1990;1(2):77-84.
1989: Y Hirata; Tetsuya Taga; Masahiko Hibi; N Nakano; Toshio Hirano; Tadamitsu Kishimoto
Characterization of IL-6 receptor expression by monoclonal and polyclonal antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(9):2900-6.
1989: Sachiko Suematsu; Toshio Matsuda; Katsuyuki Aozasa; S Akira; N Nakano; S Ohno; J Miyazaki; K Yamamura; Toshio Hirano; Tadamitsu Kishimoto
IgG1 plasmacytosis in interleukin 6 transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(19):7547-51.
1989: K Yukawa; Hitoshi Kikutani; T Inomoto; Masahiro Uehira; S H Bin; K Akagi; K Yamamura; Tadamitsu Kishimoto
Strain dependency of B and T lymphoma development in immunoglobulin heavy chain enhancer (E mu)-myc transgenic mice.
The Journal of experimental medicine 1989;170(3):711-26.
1989: Tetsuya Taga; Masahiko Hibi; Y Hirata; K Yamasaki; K Yasukawa; Toshio Matsuda; Toshio Hirano; Tadamitsu Kishimoto
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130.
Cell 1989;58(3):573-81.
1989: Tadamitsu Kishimoto
The biology of interleukin-6.
Blood 1989;74(1):1-10.
1989: Norihiro Nishimoto; Kazuyuki Yoshizaki; H Tagoh; Morito Monden; S Kishimoto; Toshio Hirano; Tadamitsu Kishimoto
Elevation of serum interleukin 6 prior to acute phase proteins on the inflammation by surgical operation.
Clinical immunology and immunopathology 1989;50(3):399-401.
1989: K Nakajima; Otoniel Martínez-Maza; Toshio Hirano; Elizabeth Crabb Breen; P Nishanian; JF Salazar-Gonzalez; John L Fahey; Tadamitsu Kishimoto
Induction of IL-6 (B cell stimulatory factor-2/IFN-beta 2) production by HIV.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(2):531-6.
1989: Toshio Matsuda; K Yamasaki; Tetsuya Taga; Toshio Hirano; Tadamitsu Kishimoto
Current concepts of B cell modulation.
International reviews of immunology 1989;5(2):97-109.
1989: Toshio Matsuda; Sachiko Suematsu; M Kawano; K Yoshizaki; B Tang; O Tanabe; T Nakajima; S Akira; Toshio Hirano; Tadamitsu Kishimoto
IL-6/BSF2 in normal and abnormal regulation of immune responses.
Annals of the New York Academy of Sciences 1989;557():466-76; discussion 476-7.
1989: Toshio Hirano; Tetsuya Taga; K Yamasaki; Toshio Matsuda; K Yasukawa; Y Hirata; H Yawata; O Tanabe; S Akira; Tadamitsu Kishimoto
Molecular cloning of the cDNAs for interleukin-6/B cell stimulatory factor 2 and its receptor.
Annals of the New York Academy of Sciences 1989;557():167-78, discussion 178-80.
1989: Hitoshi Kikutani; A Yokota; N Uchibayashi; K Yukawa; T Tanaka; K Sugiyama; E L Barsumian; Masaki Suemura; Tadamitsu Kishimoto
Structure and function of Fc epsilon receptor II (Fc epsilon RII/CD23): a point of contact between the effector phase of allergy and B cell differentiation.
Ciba Foundation symposium 1989;147():23-31; discussion 31-5.
1989: Tadamitsu Kishimoto; Tetsuya Taga; K Yamasaki; Toshio Matsuda; B Tang; Atsushi Muraguchi; Y Horii; Sachiko Suematsu; Y Hirata; H Yawata
Normal and abnormal regulation of human B cell differentiation by a new cytokine, BSF2/IL-6.
Advances in experimental medicine and biology 1989;254():135-43.
1989: Toshio Hirano; Tadamitsu Kishimoto
Interleukin-6: possible implications in human diseases.
La Ricerca in clinica e in laboratorio 1989;19(1):1-10.
1989: Tetsuya Taga; Masahiko Hibi; Y Hirata; H Yawata; Shunji Natsuka; K Yasukawa; T Totsuka; K Yamasaki; Toshio Hirano; Tadamitsu Kishimoto
Interleukin-6 receptor and a unique mechanism of its signal transduction.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 2():713-22.
1989: Masahiro Uehira; M Uno; T Kürner; Hitoshi Kikutani; K Mori; T Inomoto; T Uede; J Miyazaki; H Nishimoto; Tadamitsu Kishimoto
Development of autoimmune insulitis is prevented in E alpha d but not in A beta k NOD transgenic mice.
International immunology 1989;1(2):209-13.
1989: Toshio Hirano; Tadamitsu Kishimoto
Interleukin 6 and plasma cell neoplasias.
Progress in growth factor research 1989;1(3):133-42.
1989: Toshio Matsuda; Toshio Hirano; S Nagasawa; Tadamitsu Kishimoto
Identification of alpha 2-macroglobulin as a carrier protein for IL-6.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(1):148-52.
1988: O Tanabe; S Akira; T Kamiya; G G Wong; Toshio Hirano; Tadamitsu Kishimoto
Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(11):3875-81.
1988: A Yokota; Hitoshi Kikutani; T Tanaka; R Sato; E L Barsumian; Masaki Suemura; Tadamitsu Kishimoto
Two species of human Fc epsilon receptor II (Fc epsilon RII/CD23): tissue-specific and IL-4-specific regulation of gene expression.
Cell 1988;55(4):611-8.
1988: Y Horii; Atsushi Muraguchi; Sachiko Suematsu; Toshio Matsuda; K Yoshizaki; Toshio Hirano; Tadamitsu Kishimoto
Regulation of BSF-2/IL-6 production by human mononuclear cells. Macrophage-dependent synthesis of BSF-2/IL-6 by T cells.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(5):1529-35.
1988: K Yamasaki; Tetsuya Taga; Y Hirata; H Yawata; Y Kawanishi; B Seed; Tadatsugu Taniguchi; Toshio Hirano; Tadamitsu Kishimoto
Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor.
Science (New York, N.Y.) 1988;241(4867):825-8.
1988: Toshio Matsuda; Toshio Hirano; Tadamitsu Kishimoto
Establishment of an interleukin 6 (IL 6)/B cell stimulatory factor 2-dependent cell line and preparation of anti-IL 6 monoclonal antibodies.
European journal of immunology 1988;18(6):951-6.
1988: Atsushi Muraguchi; Toshio Hirano; B Tang; Toshio Matsuda; Y Horii; K Nakajima; Tadamitsu Kishimoto
The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells.
The Journal of experimental medicine 1988;167(2):332-44.
1988: Tadamitsu Kishimoto; T Hirano
Molecular regulation of B lymphocyte response.
Annual review of immunology 1988;6():485-512.
1988: Toshio Hirano; Toshio Matsuda; K Hosoi; A Okano; H Matsui; Tadamitsu Kishimoto
Absence of antiviral activity in recombinant B cell stimulatory factor 2 (BSF-2).
Immunology letters 1988;17(1):41-5.
1987: R R Hardy; Tadamitsu Kishimoto; K Hayakawa
Differentiation of B cell progenitors in vitro: generation of surface IgM+ B cells, including Ly-1 B cells, from Thy-1- asialoGM1+ cells in newborn liver.
European journal of immunology 1987;17(12):1769-74.
1987: N Nakano; R R Hardy; Tadamitsu Kishimoto
Identification of intrathymic T progenitor cells by expression of Thy-1, IL2 receptor and CD3.
European journal of immunology 1987;17(11):1567-71.
1987: K Yasukawa; Toshio Hirano; Y Watanabe; K Muratani; T Matsuda; S Nakai; Tadamitsu Kishimoto
Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene.
The EMBO journal 1987;6(10):2939-45.
1987: Tetsuya Taga; Y Kawanishi; R R Hardy; Toshio Hirano; Tadamitsu Kishimoto
Receptors for B cell stimulatory factor 2. Quantitation, specificity, distribution, and regulation of their expression.
The Journal of experimental medicine 1987;166(4):967-81.
1987: Tadamitsu Kishimoto
B-cell stimulatory factors (BSFs): molecular structure, biological function, and regulation of expression.
Journal of clinical immunology 1987;7(5):343-55.
1987: K Yukawa; Hitoshi Kikutani; Hajime Owaki; K Yamasaki; A Yokota; H Nakamura; E L Barsumian; R R Hardy; Masaki Suemura; Tadamitsu Kishimoto
A B cell-specific differentiation antigen, CD23, is a receptor for IgE (Fc epsilon R) on lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(8):2576-80.
1987: Masaki Suemura; Tadamitsu Kishimoto
IgE class-specific regulatory factor(s) and Fc epsilon receptors on lymphocytes.
International reviews of immunology 1987;2(1):27-42.
1986: Hitoshi Kikutani; Masaki Suemura; Hajime Owaki; H Nakamura; R Sato; K Yamasaki; E L Barsumian; R R Hardy; Tadamitsu Kishimoto
Fc epsilon receptor, a specific differentiation marker transiently expressed on mature B cells before isotype switching.
The Journal of experimental medicine 1986;164(5):1455-69.
1982: A Muraguchi; T Tachibana; Y Miki; T Kuritani; H Kishi; S Kishimoto; Y Yamamura; Tadamitsu Kishimoto
Depressed functions of T cells and the presence of suppressor macrophages in patients with sarcoidosis.
Clinical immunology and immunopathology 1982;23(2):189-201.
1982: K Yoshizaki; T Nakagawa; T Kaieda; A Muraguchi; Y Yamamura; Tadamitsu Kishimoto
Induction of proliferation and Ig production in human B leukemic cells by anti-immunoglobulins and T cell factors.
Journal of immunology (Baltimore, Md. : 1950) 1982;128(3):1296-301.
1981: A Muraguchi; Tadamitsu Kishimoto; Y Miki; T Kuritani; T Kaieda; K Yoshizaki; Y Yamamura
T cell-replacing factor- (TRF) induced IgG secretion in a human B blastoid cell line and demonstration of acceptors for TRF.
Journal of immunology (Baltimore, Md. : 1950) 1981;127(2):412-6.
1980: T Kuritani; Tadamitsu Kishimoto; A Muraguchi; Y Yamamura
In vitro immune response of human peripheral lymphocytes. VI. Distribution and characterization of precursors for PHA- and protein A-induced colony-forming B cells.
Journal of immunology (Baltimore, Md. : 1950) 1980;125(6):2633-7.
1980: A Muraguchi; Tadamitsu Kishimoto; T Kuritani; Y Yamamura
In vitro immune response of human peripheral lymphocytes. VII. Effect of anti-mu and anti-delta antibodies on B colony formation and detection of abnormal B cells in patients with juvenile rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950) 1980;125(6):2638-42.
1980: A Muraguchi; Tadamitsu Kishimoto; T Kuritani; T Watanabe; Y Yamamura
In vitro immune response of human peripheral lymphocytes. V. PHA- and protein A-induced human B colony formation and analysis of the subpopulations of B cells.
Journal of immunology (Baltimore, Md. : 1950) 1980;125(2):564-9.
1980: O Saiki; Tadamitsu Kishimoto; T Kuritani; A Muraguchi; Y Yamamura
In vitro induction of IgM secretion and switching to IgG production in human B leukemic cells with the help of T cells.
Journal of immunology (Baltimore, Md. : 1950) 1980;124(6):2609-14.