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Tadamitsu Kishimoto

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Co-Publications
Name
53
Taga, Tetsuya
36
Hirano, Toshio
34
Yoshizaki, Kazuyuki
27
Nishimoto, Norihiro
26
Naka, Tetsuji
25
Suemura, Masaki
25
Yamauchi-Takihara, Keiko
24
Kikutani, Hitoshi
19
Kasayama, Soji
19
Fujio, Yasushi
18
Matsuda, Toshio
17
Kunisada, Keita
17
Narazaki, Michiko
14
Fujimoto, Minoru
14
Sugiyama, Haruo

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Publications

TOP 3
Kimura Akihiro; Naka Tetsuji; Nakahama Taisuke; Chinen Ichino; Masuda Kazuya; Nohara Keiko; Fujii-Kuriyama Yoshiaki; Kishimoto Tadamitsu
Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses.
Mihara Masahiko; Ohsugi Yoshiyuki; Kishimoto Tadamitsu
Evidence for the role of Th17 cell inhibition in the prevention of autoimmune diseases by anti-interluekin-6 receptor antibody.
Nishimoto Norihiro; Miyasaka Nobuyuki; Yamamoto Kazuhiko; Kawai Shinichi; Takeuchi Tsutomu; Azuma Junichi; Kishimoto Tadamitsu
Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy.

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All Publications

2009: Kimura Akihiro; Naka Tetsuji; Nakahama Taisuke; Chinen Ichino; Masuda Kazuya; Nohara Keiko; Fujii-Kuriyama Yoshiaki; Kishimoto Tadamitsu
Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses.
The Journal of experimental medicine 2009;206(9):2027-35.
2009: Mihara Masahiko; Ohsugi Yoshiyuki; Kishimoto Tadamitsu
Evidence for the role of Th17 cell inhibition in the prevention of autoimmune diseases by anti-interluekin-6 receptor antibody.
BioFactors (Oxford, England) 2009;35(1):47-51.
2009: Nishimoto Norihiro; Miyasaka Nobuyuki; Yamamoto Kazuhiko; Kawai Shinichi; Takeuchi Tsutomu; Azuma Junichi; Kishimoto Tadamitsu
Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy.
Modern rheumatology / the Japan Rheumatism Association 2009;19(1):12-9.
2008: Fujimoto Minoru; Serada Satoshi; Mihara Masahiko; Uchiyama Yasushi; Yoshida Hiroto; Koike Nobuo; Ohsugi Yoshiyuki; Nishikawa Teppei; Ripley Barry; Kimura Akihiro; Kishimoto Tadamitsu; Naka Tetsuji
Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses.
Arthritis and rheumatism 2008;58(12):3710-9.
2008: Kimura Akihiro; Naka Tetsuji; Nohara Keiko; Fujii-Kuriyama Yoshiaki; Kishimoto Tadamitsu
Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(28):9721-6.
2008: Yu Cheng-Rong; Mahdi Rashid M; Liu Xuebin; Zhang Allen; Naka Tetsuji; Kishimoto Tadamitsu; Egwuagu Charles E
SOCS1 regulates CCR7 expression and migration of CD4+ T cells into peripheral tissues.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):1190-8.
2008: Serada Satoshi; Fujimoto Minoru; Mihara Masahiko; Koike Nobuo; Ohsugi Yoshiyuki; Nomura Shintaro; Yoshida Hiroto; Nishikawa Teppei; Terabe Fumitaka; Ohkawara Tomoharu; Takahashi Tsuyoshi; Ripley Barry; Kimura Akihiro; Kishimoto Tadamitsu; Naka Tetsuji
IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(26):9041-6.
2008: Horino Jiro; Fujimoto Minoru; Terabe Fumitaka; Serada Satoshi; Takahashi Tsuyoshi; Soma Yoshihito; Tanaka Kentaro; Chinen Takatoshi; Yoshimura Akihiko; Nomura Shintaro; Kawase Ichiro; Hayashi Norio; Kishimoto Tadamitsu; Naka Tetsuji
Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice.
International immunology 2008;20(6):753-62.
2008: Ohsugi Yoshiyuki; Kishimoto Tadamitsu
The recombinant humanized anti-IL-6 receptor antibody tocilizumab, an innovative drug for the treatment of rheumatoid arthritis.
Expert opinion on biological therapy 2008;8(5):669-81.
2008: Yokota Shumpei; Imagawa Tomoyuki; Mori Masaaki; Miyamae Takako; Aihara Yukoh; Takei Shuji; Iwata Naomi; Umebayashi Hiroaki; Murata Takuji; Miyoshi Mari; Tomiita Minako; Nishimoto Norihiro; Kishimoto Tadamitsu
Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial.
Lancet 2008;371(9617):998-1006.
2008: Iwanami Keiichi; Matsumoto Isao; Tanaka-Watanabe Yoko; Inoue Asuka; Mihara Masahiko; Ohsugi Yoshiyuki; Mamura Mizuko; Goto Daisuke; Ito Satoshi; Tsutsumi Akito; Kishimoto Tadamitsu; Sumida Takayuki
Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase.
Arthritis and rheumatism 2008;58(3):754-63.
2008: Seki Ekihiro; Kondo Yuichi; Iimuro Yuji; Naka Tetsuji; Son Gakuhei; Kishimoto Tadamitsu; Fujimoto Jiro; Tsutsui Hiroko; Nakanishi Kenji
Demonstration of cooperative contribution of MET- and EGFR-mediated STAT3 phosphorylation to liver regeneration by exogenous suppressor of cytokine signalings.
Journal of hepatology 2008;48(2):237-45.
2007: Nishimoto Norihiro; Hashimoto Jun; Miyasaka Nobuyuki; Yamamoto Kazuhiko; Kawai Shinichi; Takeuchi Tsutomu; Murata Norikazu; van der Heijde Désirée; Kishimoto Tadamitsu
Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab.
Annals of the rheumatic diseases 2007;66(9):1162-7.
2007: Kimura Akihiro; Naka Tetsuji; Kishimoto Tadamitsu
IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(29):12099-104.
2007: Finotto Susetta; Eigenbrod Tatjana; Karwot Roman; Boross Ildiko; Doganci Aysefa; Ito Hiroaki; Nishimoto Norihiro; Yoshizaki Kazuyuki; Kishimoto Tadamitsu; Rose-John Stefan; Galle Peter R; Neurath Markus F
Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells.
International immunology 2007;19(6):685-93.
2007: Kimura Ryusuke; Maeda Makiko; Arita Atsushi; Oshima Yuichi; Obana Masanori; Ito Takashi; Yamamoto Yasuhiro; Mohri Tomomi; Kishimoto Tadamitsu; Kawase Ichiro; Fujio Yasushi; Azuma Junichi
Identification of cardiac myocytes as the target of interleukin 11, a cardioprotective cytokine.
Cytokine 2007;38(2):107-15.
2007: Kanatani Yukiko; Usui Isao; Ishizuka Ken; Bukhari Agussalim; Fujisaka Shiho; Urakaze Masaharu; Haruta Tetsuro; Kishimoto Tadamitsu; Naka Tetsuji; Kobayashi Masashi
Effects of pioglitazone on suppressor of cytokine signaling 3 expression: potential mechanisms for its effects on insulin sensitivity and adiponectin expression.
Diabetes 2007;56(3):795-803.
2006: Nishimoto Norihiro; Kishimoto Tadamitsu
Interleukin 6: from bench to bedside.
Nature clinical practice. Rheumatology 2006;2(11):619-26.
2006: Straub Rainer H; Härle Peter; Yamana Seizo; Matsuda Takemasa; Takasugi Kiyoshi; Kishimoto Tadamitsu; Nishimoto Norihiro
Anti-interleukin-6 receptor antibody therapy favors adrenal androgen secretion in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study.
Arthritis and rheumatism 2006;54(6):1778-85.
2006: Ouyang Xinshou; Fujimoto Minoru; Nakagawa Reiko; Serada Satoshi; Tanaka Toshio; Nomura Shintaro; Kawase Ichiro; Kishimoto Tadamitsu; Naka Tetsuji
SOCS-2 interferes with myotube formation and potentiates osteoblast differentiation through upregulation of JunB in C2C12 cells.
Journal of cellular physiology 2006;207(2):428-36.
2006: Mohri Tomomi; Fujio Yasushi; Maeda Makiko; Ito Takashi; Iwakura Tomohiko; Oshima Yuichi; Uozumi Yoriko; Segawa Masashi; Yamamoto Hiroshi; Kishimoto Tadamitsu; Azuma Junichi
Leukemia inhibitory factor induces endothelial differentiation in cardiac stem cells.
The Journal of biological chemistry 2006;281(10):6442-7.
2006: Kishimoto Tadamitsu
Interleukin-6: discovery of a pleiotropic cytokine.
Arthritis research & therapy 2006;8 Suppl 2():S2.
2005: Kimura Akihiro; Naka Tetsuji; Muta Tatsushi; Takeuchi Osamu; Akira Shizuo; Kawase Ichiro; Kishimoto Tadamitsu
Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(47):17089-94.
2005: Nishimoto Norihiro; Kanakura Yuzuru; Aozasa Katsuyuki; Johkoh Takeshi; Nakamura Minoru; Nakano Shuji; Nakano Nobuaki; Ikeda Yasuo; Sasaki Takeshi; Nishioka Kiyoshi; Hara Masamichi; Taguchi Hirokuni; Kimura Yukihiko; Kato Yoshiro; Asaoku Hideki; Kumagai Shunichi; Kodama Fumio; Nakahara Hideko; Hagihara Keisuke; Yoshizaki Kazuyuki; Kishimoto Tadamitsu
Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease.
Blood 2005;106(8):2627-32.
2005: Kishimoto Tadamitsu
IL-6: from laboratory to bedside.
Clinical reviews in allergy & immunology 2005;28(3):177-86.
2005: Sugimoto Kanji; Nishimoto Norihiro; Kishimoto Tadamitsu; Yoshizaki Kazuyuki; Nishimura Tsunehiko
Imaging of lesions in a murine rheumatoid arthritis model with a humanized anti-interleukin-6 receptor antibody.
Annals of nuclear medicine 2005;19(4):261-6.
2005: Kai Yasuyuki; Takahashi Ichiro; Ishikawa Hiromichi; Hiroi Takachika; Mizushima Tsunekazu; Matsuda Chu; Kishi Daisuke; Hamada Hiromasa; Tamagawa Hiroshi; Ito Toshinori; Yoshizaki Kazuyuki; Kishimoto Tadamitsu; Matsuda Hikaru; Kiyono Hiroshi
Colitis in mice lacking the common cytokine receptor gamma chain is mediated by IL-6-producing CD4+ T cells.
Gastroenterology 2005;128(4):922-34.
2005: Yokota Shumpei; Miyamae Takako; Imagawa Tomoyuki; Iwata Naomi; Katakura Shigeki; Mori Masaaki; Woo Patricia; Nishimoto Norihiro; Yoshizaki Kazuyuki; Kishimoto Tadamitsu
Therapeutic efficacy of humanized recombinant anti-interleukin-6 receptor antibody in children with systemic-onset juvenile idiopathic arthritis.
Arthritis and rheumatism 2005;52(3):818-25.
2005: Seki Ekihiro; Tsutsui Hiroko; Iimuro Yuji; Naka Tetsuji; Son Gakuhei; Akira Shizuo; Kishimoto Tadamitsu; Nakanishi Kenji; Fujimoto Jiro
Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration.
Hepatology (Baltimore, Md.) 2005;41(3):443-50.
2005: Inaba Makiko; Saito Hiroshi; Fujimoto Minoru; Sumitani Satoru; Ohkawara Tomoharu; Tanaka Toshio; Kouhara Haruhiko; Kasayama Soji; Kawase Ichiro; Kishimoto Tadamitsu; Naka Tetsuji
Suppressor of cytokine signaling 1 suppresses muscle differentiation through modulation of IGF-I receptor signal transduction.
Biochemical and biophysical research communications 2005;328(4):953-61.
2005: Doganci Aysefa; Eigenbrod Tatjana; Krug Norbert; De Sanctis George T; Hausding Michael; Erpenbeck Veit J; Haddad El-Bdaoui; Lehr Hans A; Schmitt Edgar; Bopp Tobias; Kallen Karl-J; Herz Udo; Schmitt Steffen; Luft Cornelia; Hecht Olaf; Hohlfeld Jens M; Ito Hiroaki; Nishimoto Norihiro; Yoshizaki Kazuyuki; Kishimoto Tadamitsu; Rose-John Stefan; Renz Harald; Neurath Markus F; Galle Peter R; Finotto Susetta
The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo.
The Journal of clinical investigation 2005;115(2):313-25.
2005: Oshima Yuichi; Fujio Yasushi; Nakanishi Tsuyoshi; Itoh Norio; Yamamoto Yasuhiro; Negoro Shinji; Tanaka Keiichi; Kishimoto Tadamitsu; Kawase Ichiro; Azuma Junichi
STAT3 mediates cardioprotection against ischemia/reperfusion injury through metallothionein induction in the heart.
Cardiovascular research 2005;65(2):428-35.
2005: Woo Patricia; Wilkinson Nicholas; Prieur Anne-Marie; Southwood Taunton; Leone Valentina; Livermore Polly; Wythe Helena; Thomson David; Kishimoto Tadamitsu
Open label phase II trial of single, ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis: proof of principle of the efficacy of IL-6 receptor blockade in this type of arthritis and demonstration of prolonged clinical improvement.
Arthritis research & therapy 2005;7(6):R1281-8.
2005: Kishimoto Tadamitsu
Interleukin-6: from basic science to medicine--40 years in immunology.
Annual review of immunology 2005;23():1-21.
2004: Watanabe Dai; Naka Tetsuji; Kishimoto Tadamitsu
Implication of SOCS-1 gene methylation in acute myeloid leukaemia.
British journal of haematology 2004;127(5):608-9.
2004: Kunitomi Akane; Konaka Yoshiteru; Yagita Masato; Nishimoto Norihiro; Kishimoto Tadamitsu; Takatsuki Kiyoshi
Humanized anti-interleukin 6 receptor antibody induced long-term remission in a patient with life-threatening refractory autoimmune hemolytic anemia.
International journal of hematology 2004;80(3):246-9.
2004: Becker Christoph; Fantini Massimo C; Schramm Christoph; Lehr Hans A; Wirtz Stefan; Nikolaev Alexei; Burg Jürgen; Strand Susanne; Kiesslich Ralf; Huber Samuel; Ito Hiroaki; Nishimoto Norihiro; Yoshizaki Kazuyuki; Kishimoto Tadamitsu; Galle Peter R; Blessing Manfred; Rose-John Stefan; Neurath Markus F
TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.
Immunity 2004;21(4):491-501.
2004: Watanabe Dai; Ezoe Sachiko; Fujimoto Minoru; Kimura Akihiro; Saito Yoshiyuki; Nagai Hisaki; Tachibana Isao; Matsumura Itaru; Tanaka Toshio; Kanegane Hirokazu; Miyawaki Toshio; Emi Mitsuru; Kanakura Yuzuru; Kawase Ichiro; Naka Tetsuji; Kishimoto Tadamitsu
Suppressor of cytokine signalling-1 gene silencing in acute myeloid leukaemia and human haematopoietic cell lines.
British journal of haematology 2004;126(5):726-35.
2004: Fujio Yasushi; Matsuda Takahisa; Oshima Yuichi; Maeda Makiko; Mohri Tomomi; Ito Takashi; Takatani Tomoka; Hirata Mayo; Nakaoka Yoshikazu; Kimura Ryusuke; Kishimoto Tadamitsu; Azuma Junichi
Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes.
FEBS letters 2004;573(1-3):202-6.
2004: Nishimoto Norihiro; Kishimoto Tadamitsu
Inhibition of IL-6 for the treatment of inflammatory diseases.
Current opinion in pharmacology 2004;4(4):386-91.
2004: Kimura Akihiro; Naka Tetsuji; Nagata Shigekazu; Kawase Ichiro; Kishimoto Tadamitsu
SOCS-1 suppresses TNF-alpha-induced apoptosis through the regulation of Jak activation.
International immunology 2004;16(7):991-9.
2004: Nishimoto Norihiro; Yoshizaki Kazuyuki; Miyasaka Nobuyuki; Yamamoto Kazuhiko; Kawai Shinichi; Takeuchi Tsutomu; Hashimoto Jun; Azuma Junichi; Kishimoto Tadamitsu
Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial.
Arthritis and rheumatism 2004;50(6):1761-9.
2004: Mihara Masahiko; Shiina Masashi; Nishimoto Norihiro; Yoshizaki Kazuyuki; Kishimoto Tadamitsu; Akamatsu Ken-Ichi
Anti-interleukin 6 receptor antibody inhibits murine AA-amyloidosis.
The Journal of rheumatology 2004;31(6):1132-8.
2004: Komazaki Toshiaki; Nagai Hisaki; Emi Mitsuru; Terada Yoshie; Yabe Aya; Jin Enjing; Kawanami Ooiti; Konishi Noboru; Moriyama Yukichi; Naka Tetsuji; Kishimoto Tadamitsu
Hypermethylation-associated inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human pancreatic cancers.
Japanese journal of clinical oncology 2004;34(4):191-4.
2004: Ito Hiroaki; Takazoe Masakazu; Fukuda Yoshihiro; Hibi Toshifumi; Kusugami Kazuo; Andoh Akira; Matsumoto Takayuki; Yamamura Takehira; Azuma Junichi; Nishimoto Norihiro; Yoshizaki Kazuyuki; Shimoyama Takashi; Kishimoto Tadamitsu
A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease.
Gastroenterology 2004;126(4):989-96; discussion 947.
2004: Fujimoto Minoru; Tsutsui Hiroko; Xinshou Ouyang; Tokumoto Masanori; Watanabe Dai; Shima Yoshihito; Yoshimoto Tomohiro; Hirakata Hideki; Kawase Ichiro; Nakanishi Kenji; Kishimoto Tadamitsu; Naka Tetsuji
Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases.
International immunology 2004;16(2):303-14.
2003: Nishimoto Norihiro; Yoshizaki Kazuyuki; Maeda Keiji; Kuritani Taro; Deguchi Hitoshi; Sato Bunzo; Imai Nobuyuki; Suemura Masaki; Kakehi Takahiro; Takagi Nobuhiro; Kishimoto Tadamitsu
Toxicity, pharmacokinetics, and dose-finding study of repetitive treatment with the humanized anti-interleukin 6 receptor antibody MRA in rheumatoid arthritis. Phase I/II clinical study.
The Journal of rheumatology 2003;30(7):1426-35.
2003: Nakahara Hideko; Song Jian; Sugimoto Masamichi; Hagihara Keisuke; Kishimoto Tadamitsu; Yoshizaki Kazuyuki; Nishimoto Norihiro
Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis.
Arthritis and rheumatism 2003;48(6):1521-9.
2003: Ara Toshiaki; Nakamura Yuri; Egawa Takeshi; Sugiyama Tatsuki; Abe Kuniya; Kishimoto Tadamitsu; Matsui Yasuhisa; Nagasawa Takashi
Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1).
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5319-23.
2003: Okamura T; Kishimoto T; Inoue M; Honda M; Yamashita N; Wakiguchi H; Yagita M; Hosoi G; Sako M; Yasui M; Yagi K; Kawa K
Unrelated bone marrow transplantation for Epstein-Barr virus-associated T/NK-cell lymphoproliferative disease.
Bone marrow transplantation 2003;31(2):105-11.
2003: Yamaguchi Norihiko; Ohshima Shiro; Umeshita-Sasai Mitsuko; Nishioka Katsuhiro; Kobayashi Hideyuki; Mima Toru; Kishimoto Tadamitsu; Saeki Yukihiko
Synergistic effect on the attenuation of collagen induced arthritis in tumor necrosis factor receptor I (TNFRI) and interleukin 6 double knockout mice.
The Journal of rheumatology 2003;30(1):22-7.
2003: Nagai Hisaki; Naka Tetsuji; Terada Yoshie; Komazaki Toshiaki; Yabe Aya; Jin Enjing; Kawanami Oichi; Kishimoto Tadamitsu; Konishi Noboru; Nakamura Mitsutoshi; Kobayashi Yasuhito; Emi Mitsuru
Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human hepatoblastomas.
Journal of human genetics 2003;48(2):65-9.
2002: Katsume Asao; Saito Hiroyuki; Yamada Yoshiki; Yorozu Keigo; Ueda Otoya; Akamatsu Ken-ichi; Nishimoto Norihiro; Kishimoto Tadamitsu; Yoshizaki Kazuyuki; Ohsugi Yoshiyuki
Anti-interleukin 6 (IL-6) receptor antibody suppresses Castleman's disease like symptoms emerged in IL-6 transgenic mice.
Cytokine 2002;20(6):304-11.
2002: Ito Hiroaki; Hirotani Tomonori; Yamamoto Mitsunari; Ogawa Hiroyuki; Kishimoto Tadamitsu
Anti-IL-6 receptor monoclonal antibody inhibits leukocyte recruitment and promotes T-cell apoptosis in a murine model of Crohn's disease.
Journal of gastroenterology 2002;37 Suppl 14():56-61.
2002: Nakagawa Reiko; Naka Tetsuji; Tsutsui Hiroko; Fujimoto Minoru; Kimura Akihiro; Abe Tatsuo; Seki Ekihiro; Sato Shintaro; Takeuchi Osamu; Takeda Kiyoshi; Akira Shizuo; Yamanishi Koichi; Kawase Ichirou; Nakanishi Kenji; Kishimoto Tadamitsu
SOCS-1 participates in negative regulation of LPS responses.
Immunity 2002;17(5):677-87.
2002: Fujimoto Minoru; Tsutsui Hiroko; Yumikura-Futatsugi Shizue; Ueda Haruyasu; Xingshou Ouyang; Abe Tatsuo; Kawase Ichiro; Nakanishi Kenji; Kishimoto Tadamitsu; Naka Tetsuji
A regulatory role for suppressor of cytokine signaling-1 in T(h) polarization in vivo.
International immunology 2002;14(11):1343-50.
2002: Seki Yoh-Ichi; Hayashi Katsuhiko; Matsumoto Akira; Seki Noriyasu; Tsukada Jun; Ransom John; Naka Tetsuji; Kishimoto Tadamitsu; Yoshimura Akihiko; Kubo Masato
Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):13003-8.
2002: Kobayashi Hideyuki; Ohshima Shiro; Nishioka Katsuhiro; Yamaguchi Norihiko; Umeshita-Sasai Mitsuko; Ishii Taeko; Mima Toru; Kishimoto Tadamitsu; Kawase Ichiro; Saeki Yukihiko
Antigen induced arthritis (AIA) can be transferred by bone marrow transplantation: evidence that interleukin 6 is essential for induction of AIA.
The Journal of rheumatology 2002;29(6):1176-82.
2002: Suido Hirohisa; Tanaka Toshio; Tabei Toshio; Takeuchi Akira; Okita Misako; Kishimoto Tadamitsu; Kasayama Soji; Higashino Kazuya
A mixed green vegetable and fruit beverage decreased the serum level of low-density lipoprotein cholesterol in hypercholesterolemic patients.
Journal of agricultural and food chemistry 2002;50(11):3346-50.
2002: Elisseeva Olga A; Oka Yoshihiro; Tsuboi Akihiro; Ogata Kiyoyuki; Wu Fei; Kim Eui Ho; Soma Toshihiro; Tamaki Hiroya; Kawakami Manabu; Oji Yusuke; Hosen Naoki; Kubota Takeshi; Nakagawa Masashi; Yamagami Tamotsu; Hiraoka Akira; Tsukaguchi Machiko; Udaka Keiko; Ogawa Hiroyasu; Kishimoto Tadamitsu; Nomura Taisei; Sugiyama Haruo
Humoral immune responses against Wilms tumor gene WT1 product in patients with hematopoietic malignancies.
Blood 2002;99(9):3272-9.
2002: Sakuda Shigeru; Tamura Shinji; Yamada Akira; Miyagawa Jun ichiro; Yamamoto Koji; Kiso Shinichi; Ito Nobuyuki; Imanaka Kazuho; Wada Akira; Naka Tetsuji; Kishimoto Tadamitsu; Kawata Sumio; Matsuzawa Yuji
Activation of signal transducer and activator transcription 3 and expression of suppressor of cytokine signal 1 during liver regeneration in rats.
Journal of hepatology 2002;36(3):378-84.
2002: Matsumoto M; Kotani M; Fujita A; Higa S; Kishimoto T; Suemura M; Tanaka T
Oral administration of persimmon leaf extract ameliorates skin symptoms and transepidermal water loss in atopic dermatitis model mice, NC/Nga.
The British journal of dermatology 2002;146(2):221-7.
2002: Kovalchuk Alexander L; Kim Joong Su; Park Sung Sup; Coleman Allen E; Ward Jerrold M; Morse Herbert C; Kishimoto Tadamitsu; Potter Michael; Janz Siegfried
IL-6 transgenic mouse model for extraosseous plasmacytoma.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1509-14.
2002: Osugi Tomoaki; Oshima Yuichi; Fujio Yasushi; Funamoto Masanobu; Yamashita Atsuko; Negoro Shinji; Kunisada Keita; Izumi Masahiro; Nakaoka Yoshikazu; Hirota Hisao; Okabe Masaru; Yamauchi-Takihara Keiko; Kawase Ichiro; Kishimoto Tadamitsu
Cardiac-specific activation of signal transducer and activator of transcription 3 promotes vascular formation in the heart.
The Journal of biological chemistry 2002;277(8):6676-81.
2002: Naka Tetsuji; Nishimoto Norihiro; Kishimoto Tadamitsu
The paradigm of IL-6: from basic science to medicine.
Arthritis research 2002;4 Suppl 3():S233-42.
2002: Naka Tetsuji; Kishimoto Tadamitsu
Joint disease caused by defective gp130-mediated STAT signaling.
Arthritis research 2002;4(3):154-6.
2001: Yagita M; Iwakura H; Kishimoto T; Okamura T; Kunitomi A; Tabata R; Konaka Y; Kawa K
Successful allogeneic stem cell transplantation from an unrelated donor for aggressive Epstein-Barr virus-associated clonal T-cell proliferation with hemophagocytosis.
International journal of hematology 2001;74(4):451-4.
2001: Aoki Y; Narazaki M; Kishimoto T; Tosato G
Receptor engagement by viral interleukin-6 encoded by Kaposi sarcoma-associated herpesvirus.
Blood 2001;98(10):3042-9.
2001: Watanabe D; Hashimoto S; Ishiai M; Matsushita M; Baba Y; Kishimoto T; Kurosaki T; Tsukada S
Four tyrosine residues in phospholipase C-gamma 2, identified as Btk-dependent phosphorylation sites, are required for B cell antigen receptor-coupled calcium signaling.
The Journal of biological chemistry 2001;276(42):38595-601.
2001: Breen E C; Gage J R; Guo B; Magpantay L; Narazaki M; Kishimoto T; Miles S; Martínez-Maza O
Viral interleukin 6 stimulates human peripheral blood B cells that are unresponsive to human interleukin 6.
Cellular immunology 2001;212(2):118-25.
2001: Negoro S; Kunisada K; Fujio Y; Funamoto M; Darville M I; Eizirik D L; Osugi T; Izumi M; Oshima Y; Nakaoka Y; Hirota H; Kishimoto T; Yamauchi-Takihara K
Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutase.
Circulation 2001;104(9):979-81.
2001: Egawa T; Kawabata K; Kawamoto H; Amada K; Okamoto R; Fujii N; Kishimoto T; Katsura Y; Nagasawa T
The earliest stages of B cell development require a chemokine stromal cell-derived factor/pre-B cell growth-stimulating factor.
Immunity 2001;15(2):323-34.
2001: Izumi M; Fujio Y; Kunisada K; Negoro S; Tone E; Funamoto M; Osugi T; Oshima Y; Nakaoka Y; Kishimoto T; Yamauchi-Takihara K; Hirota H
Bone morphogenetic protein-2 inhibits serum deprivation-induced apoptosis of neonatal cardiac myocytes through activation of the Smad1 pathway.
The Journal of biological chemistry 2001;276(33):31133-41.
2001: Wang W; Tanaka T; Okamura H; Sugita M; Higa S; Kishimoto T; Suemura M
Interleukin-18 enhances the production of interleukin-8 by eosinophils.
European journal of immunology 2001;31(4):1010-6.
2001: Mihara M; Kotoh M; Nishimoto N; Oda Y; Kumagai E; Takagi N; Tsunemi K; Ohsugi Y; Kishimoto T; Yoshizaki K; Takeda Y
Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys.
Clinical immunology (Orlando, Fla.) 2001;98(3):319-26.
2001: Tanaka T; Katada Y; Higa S; Fujiwara H; Wang W; Saeki Y; Ohshima S; Okuda Y; Suemura M; Kishimoto T
Enhancement of T helper2 response in the absence of interleukin (IL-)6; an inhibition of IL-4-mediated T helper2 cell differentiation by IL-6.
Cytokine 2001;13(4):193-201.
2001: Baba Y; Hashimoto S; Matsushita M; Watanabe D; Kishimoto T; Kurosaki T; Tsukada S
BLNK mediates Syk-dependent Btk activation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2582-6.
2001: Koh N; Fujimori T; Nishiguchi S; Tamori A; Shiomi S; Nakatani T; Sugimura K; Kishimoto T; Kinoshita S; Kuroki T; Nabeshima Y
Severely reduced production of klotho in human chronic renal failure kidney.
Biochemical and biophysical research communications 2001;280(4):1015-20.
2001: Otsuki M; Saito H; Xu X; Sumitani S; Kouhara H; Kishimoto T; Kasayama S
Progesterone, but not medroxyprogesterone, inhibits vascular cell adhesion molecule-1 expression in human vascular endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(2):243-8.
2001: Kawazoe Y; Naka T; Fujimoto M; Kohzaki H; Morita Y; Narazaki M; Okumura K; Saitoh H; Nakagawa R; Uchiyama Y; Akira S; Kishimoto T
Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation.
The Journal of experimental medicine 2001;193(2):263-9.
2001: Negoro S; Oh H; Tone E; Kunisada K; Fujio Y; Walsh K; Kishimoto T; Yamauchi-Takihara K
Glycoprotein 130 regulates cardiac myocyte survival in doxorubicin-induced apoptosis through phosphatidylinositol 3-kinase/Akt phosphorylation and Bcl-xL/caspase-3 interaction.
Circulation 2001;103(4):555-61.
2000: Gage J R; Sandhu A K; Nihira M; Bonecini-Almeida M da G; Cristoforoni P; Kishimoto T; Montz F J; Martínez-Maza O
Effects of human papillomavirus-associated cells on human immunodeficiency virus gene expression.
Obstetrics and gynecology 2000;96(6):879-85.
2000: Nishimoto N; Kishimoto T; Yoshizaki K
Anti-interleukin 6 receptor antibody treatment in rheumatic disease.
Annals of the rheumatic diseases 2000;59 Suppl 1():i21-7.
2000: Yamauchi-Takihara K; Kishimoto T
A novel role for STAT3 in cardiac remodeling.
Trends in cardiovascular medicine 2000;10(7):298-303.
2000: Kishimoto T
[Immunology in the 20th century--progress made in research on infectious and immunological diseases]
Kekkaku : [Tuberculosis] 2000;75(10):595-8.
2000: Tone E; Kunisada K; Kumanogoh A; Negoro S; Funamoto M; Osugi T; Kishimoto T; Yamauchi-Takihara K
gp130-Dependent signalling pathway is not enhanced in gp130 transgenic heart after LIF stimulation.
Cytokine 2000;12(10):1512-8.
2000: Negoro S; Kunisada K; Tone E; Funamoto M; Oh H; Kishimoto T; Yamauchi-Takihara K
Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction.
Cardiovascular research 2000;47(4):797-805.
2000: Fujimoto M; Naka T; Nakagawa R; Kawazoe Y; Morita Y; Tateishi A; Okumura K; Narazaki M; Kishimoto T
Defective thymocyte development and perturbed homeostasis of T cells in STAT-induced STAT inhibitor-1/suppressors of cytokine signaling-1 transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):1799-806.
2000: Nishioka K; Ohshima S; Umeshita-Sasai M; Yamaguchi N; Mima T; Nomura S; Murata N; Shimizu M; Miyake T; Yoshizaki K; Suemura M; Kishimoto T; Saeki Y
Enhanced expression and DNA binding activity of two CCAAT/enhancer-binding protein isoforms, C/EBPbeta and C/EBPdelta, in rheumatoid synovium.
Arthritis and rheumatism 2000;43(7):1591-6.
2000: Kotani M; Matsumoto M; Fujita A; Higa S; Wang W; Suemura M; Kishimoto T; Tanaka T
Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice.
The Journal of allergy and clinical immunology 2000;106(1 Pt 1):159-66.
2000: Nomura K; Kanegane H; Karasuyama H; Tsukada S; Agematsu K; Murakami G; Sakazume S; Sako M; Tanaka R; Kuniya Y; Komeno T; Ishihara S; Hayashi K; Kishimoto T; Miyawaki T
Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway.
Blood 2000;96(2):610-7.
2000: Funamoto M; Hishinuma S; Fujio Y; Matsuda Y; Kunisada K; Oh H; Negoro S; Tone E; Kishimoto T; Yamauchi-Takihara K
Isolation and characterization of the murine cardiotrophin-1 gene: expression and norepinephrine-induced transcriptional activation.
Journal of molecular and cellular cardiology 2000;32(7):1275-84.
2000: Kovalchuk A L; Kishimoto T; Janz S
Lymph nodes and Peyer's patches of IL-6 transgenic BALB/c mice harbor T(12;15) translocated plasma cells that contain illegitimate exchanges between the immunoglobulin heavy-chain mu locus and c-myc.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2000;14(6):1127-35.
2000: Saito H; Morita Y; Fujimoto M; Narazaki M; Naka T; Kishimoto T
IFN regulatory factor-1-mediated transcriptional activation of mouse STAT-induced STAT inhibitor-1 gene promoter by IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(11):5833-43.
2000: Tsuboi A; Oka Y; Ogawa H; Elisseeva O A; Li H; Kawasaki K; Aozasa K; Kishimoto T; Udaka K; Sugiyama H
Cytotoxic T-lymphocyte responses elicited to Wilms' tumor gene WT1 product by DNA vaccination.
Journal of clinical immunology 2000;20(3):195-202.
2000: Atreya R; Mudter J; Finotto S; Müllberg J; Jostock T; Wirtz S; Schütz M; Bartsch B; Holtmann M; Becker C; Strand D; Czaja J; Schlaak J F; Lehr H A; Autschbach F; Schürmann G; Nishimoto N; Yoshizaki K; Ito H; Kishimoto T; Galle P R; Rose-John S; Neurath M F
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo.
Nature medicine 2000;6(5):583-8.
2000: Morita Y; Naka T; Kawazoe Y; Fujimoto M; Narazaki M; Nakagawa R; Fukuyama H; Nagata S; Kishimoto T
Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5405-10.
2000: Yamamoto M; Yoshizaki K; Kishimoto T; Ito H
IL-6 is required for the development of Th1 cell-mediated murine colitis.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(9):4878-82.
2000: Aono A; Enomoto H; Yoshida N; Yoshizaki K; Kishimoto T; Komori T
Forced expression of terminal deoxynucleotidyl transferase in fetal thymus resulted in a decrease in gammadelta T cells and random dissemination of Vgamma3Vdelta1 T cells in skin of newborn but not adult mice.
Immunology 2000;99(4):489-97.
2000: Funamoto M; Fujio Y; Kunisada K; Negoro S; Tone E; Osugi T; Hirota H; Izumi M; Yoshizaki K; Walsh K; Kishimoto T; Yamauchi-Takihara K
Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytes.
The Journal of biological chemistry 2000;275(14):10561-6.
2000: Enomoto H; Enomoto-Iwamoto M; Iwamoto M; Nomura S; Himeno M; Kitamura Y; Kishimoto T; Komori T
Cbfa1 is a positive regulatory factor in chondrocyte maturation.
The Journal of biological chemistry 2000;275(12):8695-702.
2000: Uchida S; Watanabe G; Shimada Y; Maeda M; Kawabe A; Mori A; Arii S; Uehata M; Kishimoto T; Oikawa T; Imamura M
The suppression of small GTPase rho signal transduction pathway inhibits angiogenesis in vitro and in vivo.
Biochemical and biophysical research communications 2000;269(2):633-40.
2000: Ohshima S; Mima T; Sasai M; Nishioka K; Shimizu M; Murata N; Yoshikawa H; Nakanishi K; Suemura M; McCloskey R V; Kishimoto T; Saeki Y
Tumour necrosis factor alpha (TNF-alpha) interferes with Fas-mediated apoptotic cell death on rheumatoid arthritis (RA) synovial cells: a possible mechanism of rheumatoid synovial hyperplasia and a clinical benefit of anti-TNF-alpha therapy for RA.
Cytokine 2000;12(3):281-8.
2000: Yamauchi-Takihara K; Kishimoto T
Cytokines and their receptors in cardiovascular diseases--role of gp130 signalling pathway in cardiac myocyte growth and maintenance.
International journal of experimental pathology 2000;81(1):1-16.
2000: Oka Y; Elisseeva O A; Tsuboi A; Ogawa H; Tamaki H; Li H; Oji Y; Kim E H; Soma T; Asada M; Ueda K; Maruya E; Saji H; Kishimoto T; Udaka K; Sugiyama H
Human cytotoxic T-lymphocyte responses specific for peptides of the wild-type Wilms' tumor gene (WT1 ) product.
Immunogenetics 2000;51(2):99-107.
2000: Oka Y; Udaka K; Tsuboi A; Elisseeva O A; Ogawa H; Aozasa K; Kishimoto T; Sugiyama H
Cancer immunotherapy targeting Wilms' tumor gene WT1 product.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(4):1873-80.
2000: Kunisada K; Negoro S; Tone E; Funamoto M; Osugi T; Yamada S; Okabe M; Kishimoto T; Yamauchi-Takihara K
Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(1):315-9.
2000: Nishimoto N; Sasai M; Shima Y; Nakagawa M; Matsumoto T; Shirai T; Kishimoto T; Yoshizaki K
Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy.
Blood 2000;95(1):56-61.
1999: Ikegame K; Yamamoto M; Kishima Y; Enomoto H; Yoshida K; Suemura M; Kishimoto T; Nakamura H
A new member of a hepatoma-derived growth factor gene family can translocate to the nucleus.
Biochemical and biophysical research communications 1999;266(1):81-7.
1999: Okuda Y; Sakoda S; Fujimura H; Saeki Y; Kishimoto T; Yanagihara T
IL-6 plays a crucial role in the induction phase of myelin oligodendrocyte glucoprotein 35-55 induced experimental autoimmune encephalomyelitis.
Journal of neuroimmunology 1999;101(2):188-96.
1999: Yoshida M; Sakuma-Mochizuki J; Abe K; Arai T; Mori M; Goya S; Matsuoka H; Hayashi S; Kaneda Y; Kishimoto T
In vivo gene transfer of an extracellular domain of platelet-derived growth factor beta receptor by the HVJ-liposome method ameliorates bleomycin-induced pulmonary fibrosis.
Biochemical and biophysical research communications 1999;265(2):503-8.
1999: Gage J R; Breen E C; Echeverri A; Magpantay L; Kishimoto T; Miles S; Martínez-Maza O
Human herpesvirus 8-encoded interleukin 6 activates HIV-1 in the U1 monocytic cell line.
AIDS (London, England) 1999;13(14):1851-5.
1999: Naka T; Fujimoto M; Kishimoto T
Negative regulation of cytokine signaling: STAT-induced STAT inhibitor.
Trends in biochemical sciences 1999;24(10):394-8.
1999: Hashimoto S; Iwamatsu A; Ishiai M; Okawa K; Yamadori T; Matsushita M; Baba Y; Kishimoto T; Kurosaki T; Tsukada S
Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling.
Blood 1999;94(7):2357-64.
1999: Ohshima S; Saeki Y; Mima T; Sasai M; Nishioka K; Ishida H; Shimizu M; Suemura M; McCloskey R; Kishimoto T
Long-term follow-up of the changes in circulating cytokines, soluble cytokine receptors, and white blood cell subset counts in patients with rheumatoid arthritis (RA) after monoclonal anti-TNF alpha antibody therapy.
Journal of clinical immunology 1999;19(5):305-13.
1999: Mima T; Ohshima S; Sasai M; Nishioka K; Shimizu M; Murata N; Yasunami R; Matsuno H; Suemura M; Kishimoto T; Saeki Y
Dominant and shared T cell receptor beta chain variable regions of T cells inducing synovial hyperplasia in rheumatoid arthritis.
Biochemical and biophysical research communications 1999;263(1):172-80.
1999: Hashimoto S; Miyawaki T; Futatani T; Kanegane H; Usui K; Nukiwa T; Namiuchi S; Matsushita M; Yamadori T; Suemura M; Kishimoto T; Tsukada S
Atypical X-linked agammaglobulinemia diagnosed in three adults.
Internal medicine (Tokyo, Japan) 1999;38(9):722-5.
1999: Breen E C; van der Meijden M; Cumberland W; Kishimoto T; Detels R; Martínez-Maza O
The development of AIDS-associated Burkitt's/small noncleaved cell lymphoma is preceded by elevated serum levels of interleukin 6.
Clinical immunology (Orlando, Fla.) 1999;92(3):293-9.
1999: Kuroda T; Tanaka H; Nakamura H; Nishimune Y; Kishimoto T
Hepatoma-derived growth factor-related protein (HRP)-1 gene in spermatogenesis in mice.
Biochemical and biophysical research communications 1999;262(2):433-7.
1999: Sasai M; Saeki Y; Ohshima S; Nishioka K; Mima T; Tanaka T; Katada Y; Yoshizaki K; Suemura M; Kishimoto T
Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6-deficient mice.
Arthritis and rheumatism 1999;42(8):1635-43.
1999: Tsuboi A; Oka Y; Ogawa H; Elisseeva O A; Tamaki H; Oji Y; Kim E H; Soma T; Tatekawa T; Kawakami M; Kishimoto T; Sugiyama H
Constitutive expression of the Wilms' tumor gene WT1 inhibits the differentiation of myeloid progenitor cells but promotes their proliferation in response to granulocyte-colony stimulating factor (G-CSF).
Leukemia research 1999;23(5):499-505.
1999: Yamadori T; Baba Y; Matsushita M; Hashimoto S; Kurosaki M; Kurosaki T; Kishimoto T; Tsukada S
Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6341-6.
1999: Kawabata K; Ujikawa M; Egawa T; Kawamoto H; Tachibana K; Iizasa H; Katsura Y; Kishimoto T; Nagasawa T
A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5663-7.
1999: Matsui H; Ihara Y; Fujio Y; Kunisada K; Akira S; Kishimoto T; Yamauchi-Takihara K
Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-kappa B and NF-IL6 in cardiac myocytes.
Cardiovascular research 1999;42(1):104-12.
1999: Inada M; Yasui T; Nomura S; Miyake S; Deguchi K; Himeno M; Sato M; Yamagiwa H; Kimura T; Yasui N; Ochi T; Endo N; Kitamura Y; Kishimoto T; Komori T
Maturational disturbance of chondrocytes in Cbfa1-deficient mice.
Developmental dynamics : an official publication of the American Association of Anatomists 1999;214(4):279-90.
1999: Tamaki H; Ogawa H; Ohyashiki K; Ohyashiki J H; Iwama H; Inoue K; Soma T; Oka Y; Tatekawa T; Oji Y; Tsuboi A; Kim E H; Kawakami M; Fuchigami K; Tomonaga M; Toyama K; Aozasa K; Kishimoto T; Sugiyama H
The Wilms' tumor gene WT1 is a good marker for diagnosis of disease progression of myelodysplastic syndromes.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1999;13(3):393-9.
1999: Baba Y; Nonoyama S; Matsushita M; Yamadori T; Hashimoto S; Imai K; Arai S; Kunikata T; Kurimoto M; Kurosaki T; Ochs H D; Yata J i; Kishimoto T; Tsukada S
Involvement of wiskott-aldrich syndrome protein in B-cell cytoplasmic tyrosine kinase pathway.
Blood 1999;93(6):2003-12.
1999: Nishimoto N; Kishimoto T; Yoshizaki K
Anticytokine therapy in autoimmune diseases.
Internal medicine (Tokyo, Japan) 1999;38(2):178-82.
1999: Oji Y; Ogawa H; Tamaki H; Oka Y; Tsuboi A; Kim E H; Soma T; Tatekawa T; Kawakami M; Asada M; Kishimoto T; Sugiyama H
Expression of the Wilms' tumor gene WT1 in solid tumors and its involvement in tumor cell growth.
Japanese journal of cancer research : Gann 1999;90(2):194-204.
1999: Yu P; Morawetz R A; Chattopadhyay S; Makino M; Kishimoto T; Kikutani H
CD40-deficient mice infected with the defective murine leukemia virus LP-BM5def do not develop murine AIDS but produce IgE and IgG1 in vivo.
European journal of immunology 1999;29(2):615-25.
1999: Deguchi K; Yagi H; Inada M; Yoshizaki K; Kishimoto T; Komori T
Excessive extramedullary hematopoiesis in Cbfa1-deficient mice with a congenital lack of bone marrow.
Biochemical and biophysical research communications 1999;255(2):352-9.
1999: Ezaki S; Maeda N; Kishimoto T; Atomi H; Imanaka T
Presence of a structurally novel type ribulose-bisphosphate carboxylase/oxygenase in the hyperthermophilic archaeon, Pyrococcus kodakaraensis KOD1.
The Journal of biological chemistry 1999;274(8):5078-82.
1999: Yoshida M; Hayashi S; Sakuma-Mochizuki J; Abe K; Arai T; Mori M; Goya S; Matsuoka H; Kaneda Y; Kishimoto T
Introduction of plasmid DNA and oligonucleotides into lung epithelial cells by the hemagglutinating virus of Japan (HVJ)-liposome method.
Somatic cell and molecular genetics 1999;25(1):49-57.
1999: Baba Y; Matsushita M; Matsuda Y; Inazawa J; Yamadori T; Hashimoto S; Kishimoto T; Tsukada S
Assignment of SH3BP5/Sh3bp5 encoding sab, an SH3 domain-binding protein which preferentially associates with Bruton's tyrosine kinase, to human chromosome 1q43 and mouse chromosome 14B by in situ hybridization.
Cytogenetics and cell genetics 1999;87(3-4):221-2.
1998: van der Meijden M; Gage J; Breen E C; Taga T; Kishimoto T; Martínez-Maza O
IL-6 receptor (CD126'IL-6R') expression is increased on monocytes and B lymphocytes in HIV infection.
Cellular immunology 1998;190(2):156-66.
1998: Tone E; Kunisada K; Fujio Y; Matsui H; Negoro S; Oh H; Kishimoto T; Yamauchi-Takihara K
Angiotensin II interferes with leukemia inhibitory factor-induced STAT3 activation in cardiac myocytes.
Biochemical and biophysical research communications 1998;253(1):147-50.
1998: Naka T; Matsumoto T; Narazaki M; Fujimoto M; Morita Y; Ohsawa Y; Saito H; Nagasawa T; Uchiyama Y; Kishimoto T
Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15577-82.
1998: Yamamoto H; Kishimoto T; Minamoto S
NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4753-9.
1998: Narazaki M; Fujimoto M; Matsumoto T; Morita Y; Saito H; Kajita T; Yoshizaki K; Naka T; Kishimoto T
Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):13130-4.
1998: Komori T; Kishimoto T
Cbfa1 in bone development.
Current opinion in genetics & development 1998;8(4):494-9.
1998: Imazeki I; Saito H; Hasegawa M; Shinkura H; Kishimoto T; Ohsugi Y
IL-6 functions in cynomolgus monkeys blocked by a humanized antibody to human IL-6 receptor.
International journal of immunopharmacology 1998;20(7):345-57.
1998: Kunisada K; Tone E; Fujio Y; Matsui H; Yamauchi-Takihara K; Kishimoto T
Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes.
Circulation 1998;98(4):346-52.
1998: Motomura T; Kasayama S; Takagi M; Kurebayashi S; Matsui H; Hirose T; Miyashita Y; Yamauchi-Takihara K; Yamamoto T; Okada S; Kishimoto T
Increased interleukin-6 production in mouse osteoblastic MC3T3-E1 cells expressing activating mutant of the stimulatory G protein.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1998;13(7):1084-91.
1998: Ohshima S; Saeki Y; Mima T; Sasai M; Nishioka K; Nomura S; Kopf M; Katada Y; Tanaka T; Suemura M; Kishimoto T
Interleukin 6 plays a key role in the development of antigen-induced arthritis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(14):8222-6.
1998: Yagi H; Deguchi K; Aono A; Tani Y; Kishimoto T; Komori T
Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice.
Blood 1998;92(1):108-17.
1998: Nagasawa T; Tachibana K; Kishimoto T
A novel CXC chemokine PBSF/SDF-1 and its receptor CXCR4: their functions in development, hematopoiesis and HIV infection.
Seminars in immunology 1998;10(3):179-85.
1998: Tachibana K; Hirota S; Iizasa H; Yoshida H; Kawabata K; Kataoka Y; Kitamura Y; Matsushima K; Yoshida N; Nishikawa S; Kishimoto T; Nagasawa T
The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract.
Nature 1998;393(6685):591-4.
1998: Okuda Y; Sakoda S; Bernard C C; Fujimura H; Saeki Y; Kishimoto T; Yanagihara T
IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein.
International immunology 1998;10(5):703-8.
1998: Wang X J; Taga T; Yoshida K; Saito M; Kishimoto T; Kikutani H
gp130, the cytokine common signal-transducer of interleukin-6 cytokine family, is downregulated in T cells in vivo by interleukin-6.
Blood 1998;91(9):3308-14.
1998: Matsushita M; Yamadori T; Kato S; Takemoto Y; Inazawa J; Baba Y; Hashimoto S; Sekine S; Arai S; Kunikata T; Kurimoto M; Kishimoto T; Tsukada S
Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (BtK).
Biochemical and biophysical research communications 1998;245(2):337-43.
1998: Oh H; Fujio Y; Kunisada K; Hirota H; Matsui H; Kishimoto T; Yamauchi-Takihara K
Activation of phosphatidylinositol 3-kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes.
The Journal of biological chemistry 1998;273(16):9703-10.
1998: Inoue K; Tamaki H; Ogawa H; Oka Y; Soma T; Tatekawa T; Oji Y; Tsuboi A; Kim E H; Kawakami M; Akiyama T; Kishimoto T; Sugiyama H
Wilms' tumor gene (WT1) competes with differentiation-inducing signal in hematopoietic progenitor cells.
Blood 1998;91(8):2969-76.
1998: Ogawa H; Sugiyama H; Tani Y; Soma T; Yamagami T; Tatekawa T; Oji Y; Kubota T; Kimura T; Inoue K; Nakagawa M; Sasaki K; Matsunashi T; Miyake S; Kishimoto T
High incidence of chemotherapy-induced acral erythema in female patients with non-Hodgkin's lymphoma treated with the VACOP-B regimen.
Leukemia & lymphoma 1998;29(1-2):171-7.
1998: Ueno K; Kumagai T; Kijima T; Kishimoto T; Hosoe S
Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer.
Human genetics 1998;102(1):63-8.
1998: Futatani T; Miyawaki T; Tsukada S; Hashimoto S; Kunikata T; Arai S; Kurimoto M; Niida Y; Matsuoka H; Sakiyama Y; Iwata T; Tsuchiya S; Tatsuzawa O; Yoshizaki K; Kishimoto T
Deficient expression of Bruton's tyrosine kinase in monocytes from X-linked agammaglobulinemia as evaluated by a flow cytometric analysis and its clinical application to carrier detection.
Blood 1998;91(2):595-602.
1998: Yoshizaki K; Nishimoto N; Mihara M; Kishimoto T
Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody.
Springer seminars in immunopathology 1998;20(1-2):247-59.
1998: Saeki Y; Ohshima S; Mima T; Sasai M; Nishioka K; Shimizu M; Suemura M; McCloskey R; Kishimoto T
Suboptimal clinical response to anti-tumor necrosis factor alpha (TNFalpha) antibody therapy in a patient with severe rheumatoid arthritis and lymphadenopathy.
Scandinavian journal of rheumatology 1998;27(4):303-5.
1997: Kurebayashi S; Hirose T; Miyashita Y; Kasayama S; Kishimoto T
Thiazolidinediones downregulate stearoyl-CoA desaturase 1 gene expression in 3T3-L1 adipocytes.
Diabetes 1997;46(12):2115-8.
1997: Otsuki M; Hashimoto K; Morimoto Y; Kishimoto T; Kasayama S
Circulating vascular cell adhesion molecule-1 (VCAM-1) in atherosclerotic NIDDM patients.
Diabetes 1997;46(12):2096-101.
1997: Ogawa H; Ito H; Takeda A; Kanazawa S; Yamamoto M; Nakamura H; Kimura Y; Yoshizaki K; Kishimoto T
Universal skew of T cell receptor (TCR) V beta usage for Crohn's disease (CrD).
Biochemical and biophysical research communications 1997;240(3):545-51.
1997: Tsunenari T; Koishihara Y; Nakamura A; Moriya M; Ohkawa H; Goto H; Shimazaki C; Nakagawa M; Ohsugi Y; Kishimoto T; Akamatsu K
New xenograft model of multiple myeloma and efficacy of a humanized antibody against human interleukin-6 receptor.
Blood 1997;90(6):2437-44.
1997: Izumoto Y; Kuroda T; Harada H; Kishimoto T; Nakamura H
Hepatoma-derived growth factor belongs to a gene family in mice showing significant homology in the amino terminus.
Biochemical and biophysical research communications 1997;238(1):26-32.
1997: Minamoto S; Ikegame K; Ueno K; Narazaki M; Naka T; Yamamoto H; Matsumoto T; Saito H; Hosoe S; Kishimoto T
Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.
Biochemical and biophysical research communications 1997;237(1):79-83.
1997: Naka T; Narazaki M; Hirata M; Matsumoto T; Minamoto S; Aono A; Nishimoto N; Kajita T; Taga T; Yoshizaki K; Akira S; Kishimoto T
Structure and function of a new STAT-induced STAT inhibitor.
Nature 1997;387(6636):924-9.
1997: Fujimura H; Nakatsuji Y; Sakoda S; Toyooka K; Okuda Y; Yoshikawa H; Kaido M; Saeki Y; Mima T; Kishimoto T; Yanagihara T
Demyelination in severe combined immunodeficient mice by intracisternal injection of cerebrospinal fluid cells from patients with multiple sclerosis: neuropathological investigation.
Acta neuropathologica 1997;93(6):567-78.
1997: Fujio Y; Kunisada K; Hirota H; Yamauchi-Takihara K; Kishimoto T
Signals through gp130 upregulate bcl-x gene expression via STAT1-binding cis-element in cardiac myocytes.
The Journal of clinical investigation 1997;99(12):2898-905.
1997: Hirose T; Kuroda T; Otsuki M; Takagi M; Yamamoto H; Motomura T; Kurebayashi S; Miyashita Y; Koga M; Arita N; Hayakawa T; Kishimoto T; Kasayama S
A patient with acromegaly who showed remarkable improvement of hyperglycemia after treatment with octreotide.
Internal medicine (Tokyo, Japan) 1997;36(5):345-50.
1997: Komori T; Yagi H; Nomura S; Yamaguchi A; Sasaki K; Deguchi K; Shimizu Y; Bronson R T; Gao Y H; Inada M; Sato M; Okamoto R; Kitamura Y; Yoshiki S; Kishimoto T
Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts.
Cell 1997;89(5):755-64.
1997: Tachibana K; Nakajima T; Sato A; Igarashi K; Shida H; Iizasa H; Yoshida N; Yoshie O; Kishimoto T; Nagasawa T
CXCR4/fusin is not a species-specific barrier in murine cells for HIV-1 entry.
The Journal of experimental medicine 1997;185(10):1865-70.
1997: Takagi M; Egawa T; Motomura T; Sakuma-Mochizuki J; Nishimoto N; Kasayama S; Hayashi S; Koga M; Yoshizaki K; Yoshioka T; Okuyama A; Kishimoto T
Interleukin-6 secreting phaeochromocytoma associated with clinical markers of inflammation.
Clinical endocrinology 1997;46(4):507-9.
1997: Inoue M; Minami M; Matsumoto M; Kishimoto T; Akira S
The amino acid residues immediately carboxyl-terminal to the tyrosine phosphorylation site contribute to interleukin 6-specific activation of signal transducer and activator of transcription 3.
The Journal of biological chemistry 1997;272(14):9550-5.
1997: Kumanogoh A; Marukawa S; Kumanogoh T; Hirota H; Yoshida K; Lee I S; Yasui T; Yoshida K; Taga T; Kishimoto T
Impairment of antigen-specific antibody production in transgenic mice expressing a dominant-negative form of gp130.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2478-82.
1997: Takagi M; Kasayama S; Yamamoto T; Motomura T; Hashimoto K; Yamamoto H; Sato B; Okada S; Kishimoto T
Advanced glycation endproducts stimulate interleukin-6 production by human bone-derived cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1997;12(3):439-46.
1997: Nakajima-Taniguchi C; Matsui H; Fujio Y; Nagata S; Kishimoto T; Yamauchi-Takihara K
Novel missense mutation in cardiac troponin T gene found in Japanese patient with hypertrophic cardiomyopathy.
Journal of molecular and cellular cardiology 1997;29(2):839-43.
1997: Nishimoto N; Shima Y; Yoshizaki K; Kishimoto T
Myeloma biology and therapy. Present status and future developments.
Hematology/oncology clinics of North America 1997;11(1):159-72.
1997: Inoue K; Ogawa H; Sonoda Y; Kimura T; Sakabe H; Oka Y; Miyake S; Tamaki H; Oji Y; Yamagami T; Tatekawa T; Soma T; Kishimoto T; Sugiyama H
Aberrant overexpression of the Wilms tumor gene (WT1) in human leukemia.
Blood 1997;89(4):1405-12.
1997: Katsume A; Miyai T; Suzuki H; Moriguchi Y; Kawata H; Tatsumi T; Suematsu S; Kishimoto T; Ohsugi Y
Interleukin-6 overexpression cannot generate serious disorders in severe combined immunodeficiency mice.
Clinical immunology and immunopathology 1997;82(2):117-24.
1997: Kurebayashi S; Miyashita Y; Hirose T; Kasayama S; Akira S; Kishimoto T
Characterization of mechanisms of interleukin-6 gene repression by estrogen receptor.
The Journal of steroid biochemistry and molecular biology 1997;60(1-2):11-7.
1997: Lee I S; Liu Y; Narazaki M; Hibi M; Kishimoto T; Taga T
Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin-6.
FEBS letters 1997;401(2-3):133-7.
1997: Maruo S; Oh-hora M; Ahn H J; Ono S; Wysocka M; Kaneko Y; Yagita H; Okumura K; Kikutani H; Kishimoto T; Kobayashi M; Hamaoka T; Trinchieri G; Fujiwara H
B cells regulate CD40 ligand-induced IL-12 production in antigen-presenting cells (APC) during T cell/APC interactions.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(1):120-6.
1997: Taga T; Kishimoto T
Gp130 and the interleukin-6 family of cytokines.
Annual review of immunology 1997;15():797-819.
1996: Yamauchi-Takihara K; Hirota H; Kunisada K; Matsui H; Fujio Y; Taga T; Kishimoto T
Roles of gp130 signaling pathways in cardiac myocytes: recent advances and implications for cardiovascular disease.
Journal of cardiac failure 1996;2(4 Suppl):S63-8.
1996: Tamaki H; Ogawa H; Inoue K; Soma T; Yamagami T; Miyake S; Oka Y; Oji Y; Tatekawa T; Tsuboi A; Tagawa S; Kitani T; Aozasa K; Kishimoto T; Sugiyama H; Miwa H; Kita K
Increased expression of the Wilms tumor gene (WT1) at relapse in acute leukemia.
Blood 1996;88(11):4396-8.
1996: Shima Y; Nishimoto N; Yoshizaki K; Kishimoto T
Fas antigen/APO-1 (CD95) expression on myeloma cells.
Leukemia & lymphoma 1996;23(5-6):521-31.
1996: Oka Y; Rolink A G; Andersson J; Kamanaka M; Uchida J; Yasui T; Kishimoto T; Kikutani H; Melchers F
Profound reduction of mature B cell numbers, reactivities and serum Ig levels in mice which simultaneously carry the XID and CD40 deficiency genes.
International immunology 1996;8(11):1675-85.
1996: Kunisada K; Hirota H; Fujio Y; Matsui H; Tani Y; Yamauchi-Takihara K; Kishimoto T
Activation of JAK-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytes.
Circulation 1996;94(10):2626-32.
1996: Ochi H; Tanaka T; Katada Y; Naka T; Aitani M; Hashimoto S; Maeda K; Toyoshima K; Igarashi T; Suemura M; Kishimoto T
Peripheral blood T lymphocytes and basophils, freshly isolated from house-dust-mite-sensitive patients, produce interleukin-4 in response to allergen-specific stimulation.
International archives of allergy and immunology 1996;111(3):253-61.
1996: Sasaki K; Yagi H; Bronson R T; Tominaga K; Matsunashi T; Deguchi K; Tani Y; Kishimoto T; Komori T
Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(22):12359-63.
1996: Takeda K; Kamanaka M; Tanaka T; Kishimoto T; Akira S
Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(8):3220-2.
1996: Tachibana I; Mori M; Tanio Y; Hosoe S; Sakuma T; Osaki T; Ueno K; Kumagai T; Kijima T; Kishimoto T
A 100-kDa protein tyrosine phosphorylation is concurrent with beta 1 integrin-mediated morphological differentiation in neuroblastoma and small cell lung cancer cells.
Experimental cell research 1996;227(2):230-9.
1996: Inoue K; Ogawa H; Yamagami T; Soma T; Tani Y; Tatekawa T; Oji Y; Tamaki H; Kyo T; Dohy H; Hiraoka A; Masaoka T; Kishimoto T; Sugiyama H
Long-term follow-up of minimal residual disease in leukemia patients by monitoring WT1 (Wilms tumor gene) expression levels.
Blood 1996;88(6):2267-78.
1996: Watanabe D; Yoshimura R; Khalil M; Yoshida K; Kishimoto T; Taga T; Kiyama H
Characteristic localization of gp130 (the signal-transducing receptor component used in common for IL-6/IL-11/CNTF/LIF/OSM) in the rat brain.
The European journal of neuroscience 1996;8(8):1630-40.
1996: Shi W; Inoue M; Minami M; Takeda K; Matsumoto M; Matsuda Y; Kishimoto T; Akira S
The genomic structure and chromosomal localization of the mouse STAT3 gene.
International immunology 1996;8(8):1205-11.
1996: Nagasawa T; Hirota S; Tachibana K; Takakura N; Nishikawa S; Kitamura Y; Yoshida N; Kikutani H; Kishimoto T
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1.
Nature 1996;382(6592):635-8.
1996: Yamauchi-Takihara K; Nakajima-Taniguchi C; Matsui H; Fujio Y; Kunisada K; Nagata S; Kishimoto T
Clinical implications of hypertrophic cardiomyopathy associated with mutations in the alpha-tropomyosin gene.
Heart (British Cardiac Society) 1996;76(1):63-5.
1996: Hashimoto S; Tsukada S; Matsushita M; Miyawaki T; Niida Y; Yachie A; Kobayashi S; Iwata T; Hayakawa H; Matsuoka H; Tsuge I; Yamadori T; Kunikata T; Arai S; Yoshizaki K; Taniguchi N; Kishimoto T
Identification of Bruton's tyrosine kinase (Btk) gene mutations and characterization of the derived proteins in 35 X-linked agammaglobulinemia families: a nationwide study of Btk deficiency in Japan.
Blood 1996;88(2):561-73.
1996: Yamamoto T; Ozono K; Kasayama S; Yoh K; Hiroshima K; Takagi M; Matsumoto S; Michigami T; Yamaoka K; Kishimoto T; Okada S
Increased IL-6-production by cells isolated from the fibrous bone dysplasia tissues in patients with McCune-Albright syndrome.
The Journal of clinical investigation 1996;98(1):30-5.
1996: Hirota H; Kiyama H; Kishimoto T; Taga T
Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma.
The Journal of experimental medicine 1996;183(6):2627-34.
1996: Takeshita S; Gage J R; Kishimoto T; Vredevoe D L; Martínez-Maza O
Differential regulation of IL-6 gene transcription and expression by IL-4 and IL-10 in human monocytic cell lines.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(7):2591-8.
1996: Minami M; Inoue M; Wei S; Takeda K; Matsumoto M; Kishimoto T; Akira S
STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):3963-6.
1996: Takeda K; Tanaka T; Shi W; Matsumoto M; Minami M; Kashiwamura S; Nakanishi K; Yoshida N; Kishimoto T; Akira S
Essential role of Stat6 in IL-4 signalling.
Nature 1996;380(6575):627-30.
1996: Sugiyama H; Inoue K; Ogawa H; Yamagami T; Soma T; Miyake S; Hirata M; Kishimoto T
The expression of IL-6 and its related genes in acute leukemia.
Leukemia & lymphoma 1996;21(1-2):49-52.
1996: Kamanaka M; Yu P; Yasui T; Yoshida K; Kawabe T; Horii T; Kishimoto T; Kikutani H
Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity.
Immunity 1996;4(3):275-81.
1996: Ochi H; Tanaka T; Katada Y; Naka T; Aitani M; Hashimoto S; Maeda K; Toyoshima K; Igarashi T; Suemura M; Kishimoto T
Functional disturbance of naive T lymphocytes in very high IgE producers: depletion of interleukin-4-induced interleukin-4-producing cells.
International archives of allergy and immunology 1996;109(3):236-42.
1996: Sugiyama T; Nishio Y; Kishimoto T; Akira S
Identification of alternative splicing form of Stat2.
FEBS letters 1996;381(3):191-4.
1996: Akira S; Kishimoto T
Role of interleukin-6 in macrophage function.
Current opinion in hematology 1996;3(1):87-93.
1996: Katada Y; Tanaka T; Ochi H; Aitani M; Yokota A; Kikutani H; Suemura M; Kishimoto T
B cell-B cell interaction through intercellular adhesion molecule-1 and lymphocyte functional antigen-1 regulates immunoglobulin E synthesis by B cells stimulated with interleukin-4 and anti-CD40 antibody.
European journal of immunology 1996;26(1):192-200.
1996: Yoshida K; Taga T; Saito M; Suematsu S; Kumanogoh A; Tanaka T; Fujiwara H; Hirata M; Yamagami T; Nakahata T; Hirabayashi T; Yoneda Y; Tanaka K; Wang W Z; Mori C; Shiota K; Yoshida N; Kishimoto T
Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):407-11.
1996: Kumagai T; Tanio Y; Osaki T; Hosoe S; Tachibana I; Ueno K; Kijima T; Horai T; Kishimoto T
Eradication of Myc-overexpressing small cell lung cancer cells transfected with herpes simplex virus thymidine kinase gene containing Myc-Max response elements.
Cancer research 1996;56(2):354-8.
1996: Yasui T; Fujiwara H; Kamanaka M; Kawabe T; Yoshida N; Kishimoto T; Kikutani H
The roles of CD40 and CD23 in IgE regulation.
Advances in experimental medicine and biology 1996;409():349-54.
1995: Nakajima-Taniguchi C; Matsui H; Eguchi N; Nagata S; Kishimoto T; Yamauchi-Takihara K
A novel deletion mutation in the beta-myosin heavy chain gene found in Japanese patients with hypertrophic cardiomyopathy.
Journal of molecular and cellular cardiology 1995;27(12):2607-12.
1995: Akira S; Yoshida K; Tanaka T; Taga T; Kishimoto T
Targeted disruption of the IL-6 related genes: gp130 and NF-IL-6.
Immunological reviews 1995;148():221-53.
1995: Nakajima-Taniguchi C; Azuma J; Nagata S; Kishimoto T; Yamauchi-Takihara K
A missense mutation in the beta-myosin heavy chain gene in a Japanese patient with hypertrophic cardiomyopathy.
Japanese circulation journal 1995;59(12):833-7.
1995: Yokota A; Murata N; Saiki O; Shimizu M; Springer T A; Kishimoto T
High avidity state of leukocyte function-associated antigen-1 on rheumatoid synovial fluid T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(8):4118-24.
1995: Mima T; Saeki Y; Ohshima S; Nishimoto N; Matsushita M; Shimizu M; Kobayashi Y; Nomura T; Kishimoto T
Transfer of rheumatoid arthritis into severe combined immunodeficient mice. The pathogenetic implications of T cell populations oligoclonally expanding in the rheumatoid joints.
The Journal of clinical investigation 1995;96(4):1746-58.
1995: Hashimoto K; Koga M; Motomura T; Kasayama S; Kouhara H; Ohnishi T; Arita N; Hayakawa T; Sato B; Kishimoto T
Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas.
The Journal of clinical endocrinology and metabolism 1995;80(10):2933-9.
1995: Takeshita S; Breen E C; Ivashchenko M; Nishanian P G; Kishimoto T; Vredevoe D L; Martinez-Maza O
Induction of IL-6 and IL-10 production by recombinant HIV-1 envelope glycoprotein 41 (gp41) in the THP-1 human monocytic cell line.
Cellular immunology 1995;165(2):234-42.
1995: Nakajima-Taniguchi C; Matsui H; Nagata S; Kishimoto T; Yamauchi-Takihara K
Novel missense mutation in alpha-tropomyosin gene found in Japanese patients with hypertrophic cardiomyopathy.
Journal of molecular and cellular cardiology 1995;27(9):2053-8.
1995: Kishimoto T; Tanaka T; Yoshida K; Akira S; Taga T
Cytokine signal transduction through a homo- or heterodimer of gp130.
Annals of the New York Academy of Sciences 1995;766():224-34.
1995: Kishimoto T; Akira S; Narazaki M; Taga T
Interleukin-6 family of cytokines and gp130.
Blood 1995;86(4):1243-54.
1995: Liu M; Martinez-Maza O; Johnson M T; Fan J; Kishimoto T; Plaeger S
IL-6 induces target cell resistance to HIV-specific cytotoxic lysis.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1995;9(4):321-31.
1995: Yamaguchi M; Taga T; Kishimoto T; Miyake A
Cytokines that use gp130 as a signal transducer stimulate mouse placental lactogen-I (mPL-I) but inhibit mPL-II production in vitro.
Biology of reproduction 1995;53(2):399-406.
1995: Akira S; Nishio Y; Tanaka T; Inoue M; Matsusaka T; Wang X J; Wei S; Yoshida N; Kishimoto T
Transcription factors NF-IL6 and APRF involved in gp130-mediated signaling pathway.
Annals of the New York Academy of Sciences 1995;762():15-27; discussion 27-8.
1995: Kouhara H; Kurebayashi S; Hashimoto K; Kasayama S; Koga M; Kishimoto T; Sato B
Ligand-independent activation of tyrosine kinase in fibroblast growth factor receptor 1 by fusion with beta-galactosidase.
Oncogene 1995;10(12):2315-22.
1995: Yamaguchi M; Mammoto A; Taga T; Kishimoto T; Miyake A
Regulation of mouse soluble interleukin-6 receptor secretion by decidua.
Biochemical and biophysical research communications 1995;211(3):1077-82.
1995: Oka Y; Rolink A G; Suematsu S; Kishimoto T; Melchers F
An interleukin-6 transgene expressed in B lymphocyte lineage cells overcomes the T cell-dependent establishment of normal levels of switched immunoglobulin isotypes.
European journal of immunology 1995;25(5):1332-7.
1995: Hirota H; Yoshida K; Kishimoto T; Taga T
Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):4862-6.
1995: Sawai K; Matsuzaki N; Kameda T; Hashimoto K; Okada T; Shimoya K; Nobunaga T; Taga T; Kishimoto T; Saji F
Leukemia inhibitory factor produced at the fetomaternal interface stimulates chorionic gonadotropin production: its possible implication during pregnancy, including implantation period.
The Journal of clinical endocrinology and metabolism 1995;80(4):1449-56.
1995: Yamaguchi M; Miki N; Ono M; Ohtsuka C; Demura H; Kurachi H; Inoue M; Endo H; Taga T; Kishimoto T
Inhibition of growth hormone-releasing factor production in mouse placenta by cytokines using gp130 as a signal transducer.
Endocrinology 1995;136(3):1072-8.
1995: Yamauchi-Takihara K; Ihara Y; Ogata A; Yoshizaki K; Azuma J; Kishimoto T
Hypoxic stress induces cardiac myocyte-derived interleukin-6.
Circulation 1995;91(5):1520-4.
1995: Taga T; Kishimoto T
Signaling mechanisms through cytokine receptors that share signal transducing receptor components.
Current opinion in immunology 1995;7(1):17-23.
1995: Shima Y; Nishimoto N; Ogata A; Fujii Y; Yoshizaki K; Kishimoto T
Myeloma cells express Fas antigen/APO-1 (CD95) but only some are sensitive to anti-Fas antibody resulting in apoptosis.
Blood 1995;85(3):757-64.
1995: Nakagawa M; Sugiyama H; Ogawa H; Tone S; Morishita H; Ikeda H; Aozasa K; Taniwaki M; Abe T; Kishimoto T
Intermediate lymphocytic lymphoma with both t(14;19)(q32.3;q13.1) and t(3;22)(q27;q11.2).
Cancer genetics and cytogenetics 1995;79(1):89-91.
1995: Tanaka T; Akira S; Yoshida K; Umemoto M; Yoneda Y; Shirafuji N; Fujiwara H; Suematsu S; Yoshida N; Kishimoto T
Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages.
Cell 1995;80(2):353-61.
1995: Tani Y; Nishimoto N; Ogata A; Shima Y; Yoshizaki K; Kishimoto T
Gp130 in human myeloma/plasmacytoma.
Current topics in microbiology and immunology 1995;194():229-33.
1994: Yamamoto Y; Mizuno R; Nishimura T; Ogawa Y; Yoshikawa H; Fujimura H; Adachi E; Kishimoto T; Yanagihara T; Sakoda S
Cloning and expression of myelin-associated oligodendrocytic basic protein. A novel basic protein constituting the central nervous system myelin.
The Journal of biological chemistry 1994;269(50):31725-30.
1994: Kasayama S; Koga M; Kouhara H; Sumitani S; Wada K; Kishimoto T; Sato B
Unsaturated fatty acids are required for continuous proliferation of transformed androgen-dependent cells by fibroblast growth factor family proteins.
Cancer research 1994;54(24):6441-5.
1994: Maeda T; Yamaguchi M; Taga T; Kishimoto T; Wada K; Ikegami H; Kurachi H; Miyake A
Decidua is a possible source of serum mouse soluble interleukin-6 receptor (msIL-6R): gestational profile of serum msIL-6R concentration.
Biochemical and biophysical research communications 1994;205(2):998-1003.
1994: Harada T; Saito H; Kouhara H; Kurebayashi S; Kasayama S; Terakawa N; Kishimoto T; Sato B
Murine fibroblast growth factor receptor 1 gene generates multiple messenger RNAs containing two open reading frames via alternative splicing.
Biochemical and biophysical research communications 1994;205(2):1057-63.
1994: Shimizu Y; Ogawa H; Oka Y; Mizuno R; Sakoda S; Kishimoto T; Sugiyama H
Isolation of a cDNA clone encoding a novel membrane protein expressed in lymphocytes.
FEBS letters 1994;355(1):30-4.
1994: Ogata A; Nishimoto N; Shima Y; Yoshizaki K; Kishimoto T
Inhibitory effect of all-trans retinoic acid on the growth of freshly isolated myeloma cells via interference with interleukin-6 signal transduction.
Blood 1994;84(9):3040-6.
1994: Miyashita Y; Koga M; Kouhara H; Tanaka A; Kishimoto T; Sato B
Facilitation of autonomous phenotype acquisition in androgen-dependent Shionogi carcinoma 115 cells by transfection of androgen-induced growth factor expression vector.
Japanese journal of cancer research : Gann 1994;85(11):1117-23.
1994: Widney D; Yawetz S; van der Meyden M; Miles S A; Kishimoto T; Martínez-Maza O
Effects of zidovudine on B lymphocyte activation.
Cellular immunology 1994;158(1):140-56.
1994: Nakamura H; Izumoto Y; Kambe H; Kuroda T; Mori T; Kawamura K; Yamamoto H; Kishimoto T
Molecular cloning of complementary DNA for a novel human hepatoma-derived growth factor. Its homology with high mobility group-1 protein.
The Journal of biological chemistry 1994;269(40):25143-9.
1994: Osaki T; Tanio Y; Tachibana I; Hosoe S; Kumagai T; Kawase I; Oikawa S; Kishimoto T
Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene.
Cancer research 1994;54(20):5258-61.
1994: Hashimoto K; Koga M; Kouhara H; Arita N; Hayakawa T; Kishimoto T; Sato B
Expression patterns of messenger ribonucleic acids encoding prohormone convertases (PC2 and PC3) in human pituitary adenomas.
Clinical endocrinology 1994;41(2):185-91.
1994: Kumanogoh A; Kasayama S; Kouhara H; Koga M; Arita N; Hayakawa T; Kishimoto T; Sato B
Effects of therapy on anterior pituitary functions in patients with primary intracranial germ cell tumor.
Endocrine journal 1994;41(3):287-92.
1994: Kawabe T; Naka T; Yoshida K; Tanaka T; Fujiwara H; Suematsu S; Yoshida N; Kishimoto T; Kikutani H
The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation.
Immunity 1994;1(3):167-78.
1994: Nishimoto N; Ogata A; Shima Y; Tani Y; Ogawa H; Nakagawa M; Sugiyama H; Yoshizaki K; Kishimoto T
Oncostatin M, leukemia inhibitory factor, and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer, gp130.
The Journal of experimental medicine 1994;179(4):1343-7.
1994: Hosoe S; Ueno K; Shigedo Y; Tachibana I; Osaki T; Kumagai T; Tanio Y; Kawase I; Nakamura Y; Kishimoto T
A frequent deletion of chromosome 5q21 in advanced small cell and non-small cell carcinoma of the lung.
Cancer research 1994;54(7):1787-90.
1994: Akira S; Nishio Y; Inoue M; Wang X J; Wei S; Matsusaka T; Yoshida K; Sudo T; Naruto M; Kishimoto T
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway.
Cell 1994;77(1):63-71.
1994: Nagasawa T; Kaisho T; Kishimoto T; Kikutani H
Generation and characterization of a monoclonal antibody that inhibits stromal cell-dependent B lymphopoiesis.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(6):2788-97.
1994: Nagasawa T; Kikutani H; Kishimoto T
Molecular cloning and structure of a pre-B-cell growth-stimulating factor.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(6):2305-9.
1994: Narazaki M; Witthuhn B A; Yoshida K; Silvennoinen O; Yasukawa K; Ihle J N; Kishimoto T; Taga T
Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(6):2285-9.
1994: Saito S; Tanio Y; Tachibana I; Hayashi S; Kishimoto T; Kawase I
Complementary DNA sequence encoding the major neural cell adhesion molecule isoform in a human small cell lung cancer cell line.
Lung cancer (Amsterdam, Netherlands) 1994;10(5-6):307-18.
1994: Hosoe S; Shigedo Y; Ueno K; Tachibana I; Osaki T; Tanio Y; Kawase I; Yamakawa K; Nakamura Y; Kishimoto T
Detailed deletion mapping of the short arm of chromosome 3 in small cell and non-small cell carcinoma of the lung.
Lung cancer (Amsterdam, Netherlands) 1994;10(5-6):297-305.
1994: Kouhara H; Koga M; Kasayama S; Tanaka A; Kishimoto T; Sato B
Transforming activity of a newly cloned androgen-induced growth factor.
Oncogene 1994;9(2):455-62.
1994: Yoshida K; Chambers I; Nichols J; Smith A; Saito M; Yasukawa K; Shoyab M; Taga T; Kishimoto T
Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways.
Mechanisms of development 1994;45(2):163-71.
1994: Saito H; Kouhara H; Harada T; Miyake S; Sugiyama H; Kishimoto T; Sato B
Mapping of a transcription element critical for expression of the fibroblast growth factor receptor 1 gene.
Biochemical and biophysical research communications 1994;198(3):1020-6.
1994: Kishimoto T; Taga T; Akira S
Cytokine signal transduction.
Cell 1994;76(2):253-62.
1994: Kishimoto T
Signal transduction through homo- or heterodimers of gp130.
Stem cells (Dayton, Ohio) 1994;12 Suppl 1():37-44; discussion 44-5.
1993: Ohzato H; Monden M; Yoshizaki K; Ogata A; Nishimoto N; Gotoh M; Kishimoto T; Mori T
Systemic production of interleukin-6 following acute inflammation.
Biochemical and biophysical research communications 1993;197(3):1556-62.
1993: Sato B; Kouhara H; Koga M; Kasayama S; Saito H; Sumitani S; Hashimoto K; Kishimoto T; Tanaka A; Matsumoto K
Androgen-induced growth factor and its receptor: demonstration of the androgen-induced autocrine loop in mouse mammary carcinoma cells.
The Journal of steroid biochemistry and molecular biology 1993;47(1-6):91-8.
1993: Matsusaka T; Fujikawa K; Nishio Y; Mukaida N; Matsushima K; Kishimoto T; Akira S
Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):10193-7.
1993: Yukawa K; Yasui T; Yamamoto A; Shiku H; Kishimoto T; Kikutani H
Epoc-1: a POU-domain gene expressed in murine epidermal basal cells and thymic stromal cells.
Gene 1993;133(2):163-9.
1993: Kishimoto T
[Diseases associated with cytokine dysregulation]
Nippon Sanka Fujinka Gakkai zasshi 1993;45(8):724-34.
1993: Narazaki M; Yasukawa K; Saito T; Ohsugi Y; Fukui H; Koishihara Y; Yancopoulos G D; Taga T; Kishimoto T
Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130.
Blood 1993;82(4):1120-6.
1993: Saito T; Taga T; Miki D; Futatsugi K; Yawata H; Kishimoto T; Yasukawa K
Preparation of monoclonal antibodies against the IL-6 signal transducer, gp130, that can inhibit IL-6-mediated functions.
Journal of immunological methods 1993;163(2):217-23.
1993: Murakami M; Hibi M; Nakagawa N; Nakagawa T; Yasukawa K; Yamanishi K; Taga T; Kishimoto T
IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase.
Science (New York, N.Y.) 1993;260(5115):1808-10.
1993: Suzuki H; Yasukawa K; Saito T; Narazaki M; Hasegawa A; Taga T; Kishimoto T
Serum soluble interleukin-6 receptor in MRL/lpr mice is elevated with age and mediates the interleukin-6 signal.
European journal of immunology 1993;23(5):1078-82.
1993: Yawata H; Yasukawa K; Natsuka S; Murakami M; Yamasaki K; Hibi M; Taga T; Kishimoto T
Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130.
The EMBO journal 1993;12(4):1705-12.
1993: Stahl N; Davis S; Wong V; Taga T; Kishimoto T; Ip N Y; Yancopoulos G D
Cross-linking identifies leukemia inhibitory factor-binding protein as a ciliary neurotrophic factor receptor component.
The Journal of biological chemistry 1993;268(11):7628-31.
1993: Nishio Y; Isshiki H; Kishimoto T; Akira S
A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat alpha 1-acid glycoprotein gene via direct protein-protein interaction.
Molecular and cellular biology 1993;13(3):1854-62.
1993: Nakajima T; Kinoshita S; Sasagawa T; Sasaki K; Naruto M; Kishimoto T; Akira S
Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(6):2207-11.
1993: Suematsu S; Matsusaka T; Matsuda T; Hirano T; Kishimoto T
Interleukin-6 in myeloma/plasmacytoma.
International review of experimental pathology 1993;34 Pt A():91-8.
1993: Akira S; Taga T; Kishimoto T
Interleukin-6 in biology and medicine.
Advances in immunology 1993;54():1-78.
1992: Kobayashi I; Matsuda T; Saito T; Yasukawa K; Kikutani H; Hirano T; Taga T; Kishimoto T
Abnormal distribution of IL-6 receptor in aged MRL/lpr mice: elevated expression on B cells and absence on CD4+ cells.
International immunology 1992;4(12):1407-12.
1992: Taga T; Narazaki M; Yasukawa K; Saito T; Miki D; Hamaguchi M; Davis S; Shoyab M; Yancopoulos G D; Kishimoto T
Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10998-1001.
1992: Kishimoto T; Akira S; Taga T
Interleukin-6 and its receptor: a paradigm for cytokines.
Science (New York, N.Y.) 1992;258(5082):593-7.
1992: Nakatsuji Y; Hidaka K; Tsujino S; Yamamoto Y; Mukai T; Yanagihara T; Kishimoto T; Sakoda S
A single MEF-2 site is a major positive regulatory element required for transcription of the muscle-specific subunit of the human phosphoglycerate mutase gene in skeletal and cardiac muscle cells.
Molecular and cellular biology 1992;12(10):4384-90.
1992: Smith J B; Kunjummen R D; Kishimoto T K; Anderson D C
Expression and regulation of L-selectin on eosinophils from human adults and neonates.
Pediatric research 1992;32(4):465-71.
1992: Hirano T; Kishimoto T
Molecular biology and immunology of interleukin-6.
Research in immunology 1992;143(7):723-4.
1992: Suzuki H; Yasukawa K; Saito T; Goitsuka R; Hasegawa A; Ohsugi Y; Taga T; Kishimoto T
Anti-human interleukin-6 receptor antibody inhibits human myeloma growth in vivo.
European journal of immunology 1992;22(8):1989-93.
1992: Muraguchi A; Kawamura N; Hori A; Horii Y; Ichigi Y; Kimoto M; Kishimoto T
Expression of the CD2 molecule on human B lymphoid progenitors.
International immunology 1992;4(8):841-9.
1992: Saeki Y; Mima T; Sakoda S; Fujimura H; Arita N; Nomura T; Kishimoto T
Transfer of multiple sclerosis into severe combined immunodeficiency mice by mononuclear cells from cerebrospinal fluid of the patients.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):6157-61.
1992: Yoshizaki K; Kuritani T; Kishimoto T
Interleukin-6 in autoimmune disorders.
Seminars in immunology 1992;4(3):155-66.
1992: Saito M; Yoshida K; Hibi M; Taga T; Kishimoto T
Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(12):4066-71.
1992: Shimizu Y; Oka Y; Ogawa H; Kishimoto T; Sugiyama H
Regulation of Thy-1 gene expression by the methylation of the 5' region of Thy-1 gene and intracellular regulatory factors in immature B cells.
Immunological investigations 1992;21(3):183-91.
1992: Yokota A; Yukawa K; Yamamoto A; Sugiyama K; Suemura M; Tashiro Y; Kishimoto T; Kikutani H
Two forms of the low-affinity Fc receptor for IgE differentially mediate endocytosis and phagocytosis: identification of the critical cytoplasmic domains.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(11):5030-4.
1992: Akira S; Kishimoto T
Mechanisms of soluble mediators.
Current opinion in immunology 1992;4(3):307-13.
1992: Akira S; Kishimoto T
IL-6 and NF-IL6 in acute-phase response and viral infection.
Immunological reviews 1992;127():25-50.
1992: Taniguchi T; Matsuzaki N; Jo T; Saji F; Taga T; Hirano T; Kishimoto T; Tanizawa O
Interleukin-1 (IL-1)-induced IL-6- and IL-6-receptor-mediated release of human chorionic gonadotropin by choriocarcinoma cell lines (Jar and HCCM-5) activates adenosine 3',5'-monophosphate-independent signal transduction pathway.
The Journal of clinical endocrinology and metabolism 1992;74(6):1389-95.
1992: Ito H; Kambe H; Kimura Y; Nakamura H; Hayashi E; Kishimoto T; Kishimoto S; Yamamoto H
Depression of plasma gelsolin level during acute liver injury.
Gastroenterology 1992;102(5):1686-92.
1992: Kishimoto T; Akira S; Taga T
IL-6 receptor and mechanism of signal transduction.
International journal of immunopharmacology 1992;14(3):431-8.
1992: Ogata A; Tagoh H; Lee T; Kuritani T; Takahara Y; Shimamura T; Ikegami H; Kurimoto M; Yoshizaki K; Kishimoto T
A new highly sensitive immunoassay for cytokines by dissociation-enhanced lanthanide fluoroimmunoassay (DELFIA).
Journal of immunological methods 1992;148(1-2):15-22.
1992: Kishimoto T
Interleukin-6 and its receptor in autoimmunity.
Journal of autoimmunity 1992;5 Suppl A():123-32.
1992: Miles S A; Martínez-Maza O; Rezai A; Magpantay L; Kishimoto T; Nakamura S; Radka S F; Linsley P S
Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells.
Science (New York, N.Y.) 1992;255(5050):1432-4.
1992: Saito H; Kouhara H; Kasayama S; Kishimoto T; Sato B
Characterization of the promoter region of the murine fibroblast growth factor receptor 1 gene.
Biochemical and biophysical research communications 1992;183(2):688-93.
1992: Kinoshita S; Akira S; Kishimoto T
A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1473-6.
1992: Yasukawa K; Futatsugi K; Saito T; Yawata H; Narazaki M; Suzuki H; Taga T; Kishimoto T
Association of recombinant soluble IL-6-signal transducer, gp130, with a complex of IL 6 and soluble IL-6 receptor, and establishment of an ELISA for soluble gp130.
Immunology letters 1992;31(2):123-30.
1992: Kaisho T; Nagasawa T; Kishimoto T; Kikutani H
A stromal cell-specific monoclonal antibody augments the stromal cell-dependent B lymphopoiesis.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(4):989-95.
1992: Ohzato H; Yoshizaki K; Nishimoto N; Ogata A; Tagoh H; Monden M; Gotoh M; Kishimoto T; Mori T
Interleukin-6 as a new indicator of inflammatory status: detection of serum levels of interleukin-6 and C-reactive protein after surgery.
Surgery 1992;111(2):201-9.
1992: Akira S; Kishimoto T
The evidence for interleukin-6 as an autocrine growth factor in malignancy.
Seminars in cancer biology 1992;3(1):17-26.
1992: Aitani M; Suemura M; Kishimoto T
[Immunologically mediated bronchial asthma]
Kokyu to junkan. Respiration & circulation 1992;40(2):108-11.
1992: Yamamoto Y; Kawai H; Nakahara K; Osame M; Nakatsuji Y; Kishimoto T; Sakoda S
A novel primer extension method to detect the number of CAG repeats in the androgen receptor gene in families with X-linked spinal and bulbar muscular atrophy.
Biochemical and biophysical research communications 1992;182(2):507-13.
1992: Natsuka S; Akira S; Nishio Y; Hashimoto S; Sugita T; Isshiki H; Kishimoto T
Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6.
Blood 1992;79(2):460-6.
1992: Suematsu S; Matsusaka T; Matsuda T; Ohno S; Miyazaki J; Yamamura K; Hirano T; Kishimoto T
Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(1):232-5.
1992: Taga T; Kishimoto T
Role of a two-chain IL-6 receptor system in immune and hematopoietic cell regulation.
Critical reviews in immunology 1992;11(5):265-80.
1992: Akira S; Isshiki H; Nakajima T; Kinoshita S; Nishio Y; Hashimoto S; Natsuka S; Kishimoto T
A nuclear factor for the IL-6 gene (NF-IL6).
Chemical immunology 1992;51():299-322.
1992: Kishimoto T; Hibi M; Murakami M; Narazaki M; Saito M; Taga T
The molecular biology of interleukin 6 and its receptor.
Ciba Foundation symposium 1992;167():5-16; discussion 16-23.
1992: Hirano T; Suematsu S; Matsusaka T; Matsuda T; Kishimoto T
The role of interleukin 6 in plasmacytomagenesis.
Ciba Foundation symposium 1992;167():188-96; discussion 196-200.
1992: Akira S; Isshiki H; Nakajima T; Kinoshita S; Nishio Y; Natsuka S; Kishimoto T
Regulation of expression of the interleukin 6 gene: structure and function of the transcription factor NF-IL6.
Ciba Foundation symposium 1992;167():47-62; discussion 62-7.
1991: Murakami M; Narazaki M; Hibi M; Yawata H; Yasukawa K; Hamaguchi M; Taga T; Kishimoto T
Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11349-53.
1991: Natsuka S; Isshiki H; Akira S; Kishimoto T
Augmentation of haptoglobin production in Hep3B cell line by a nuclear factor NF-IL6.
FEBS letters 1991;291(1):58-62.
1991: Suzuki H; Yasukawa K; Saito T; Anzai M; Goitsuka R; Hasegawa A; Ohsugi Y; Taga T; Kishimoto T
Anti-murine IL-6 receptor antibody inhibits IL-6 effects in vivo.
Immunology letters 1991;30(1):17-21.
1991: Sidell N; Taga T; Hirano T; Kishimoto T; Saxon A
Retinoic acid-induced growth inhibition of a human myeloma cell line via down-regulation of IL-6 receptors.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(11):3809-14.
1991: Nakano N; Kikutani H; Nishimoto H; Kishimoto T
T cell receptor V gene usage of islet beta cell-reactive T cells is not restricted in non-obese diabetic mice.
The Journal of experimental medicine 1991;173(5):1091-7.
1991: Suemura M; Kikutani H; Sugiyama K; Uchibayashi N; Aitani M; Kuritani T; Barsumian E L; Yamatodani A; Kishimoto T
Significance of soluble Fc epsilon receptor II (sFc epsilon RII/CD23) in serum and possible application of sFc epsilon RII for the prevention of allergic reactions.
Allergy proceedings : the official journal of regional and state allergy societies 1991;12(3):133-7.
1991: Tang B; Matsuda T; Akira S; Nagata N; Ikehara S; Hirano T; Kishimoto T
Age-associated increase in interleukin 6 in MRL/lpr mice.
International immunology 1991;3(3):273-8.
1991: Isshiki H; Akira S; Sugita T; Nishio Y; Hashimoto S; Pawlowski T; Suematsu S; Kishimoto T
Reciprocal expression of NF-IL6 and C/EBP in hepatocytes: possible involvement of NF-IL6 in acute phase protein gene expression.
The New biologist 1991;3(1):63-70.
1990: Hibi M; Murakami M; Saito M; Hirano T; Taga T; Kishimoto T
Molecular cloning and expression of an IL-6 signal transducer, gp130.
Cell 1990;63(6):1149-57.
1990: Hirano T; Akira S; Taga T; Kishimoto T
Biological and clinical aspects of interleukin 6.
Immunology today 1990;11(12):443-9.
1990: Inui S; Kaisho T; Kikutani H; Stamenkovic I; Seed B; Clark E A; Kishimoto T
Identification of the intracytoplasmic region essential for signal transduction through a B cell activation molecule, CD40.
European journal of immunology 1990;20(8):1747-53.
1990: Nishimoto N; Yoshizaki K; Eiraku N; Machigashira K; Tagoh H; Ogata A; Kuritani T; Osame M; Kishimoto T
Elevated levels of interleukin-6 in serum and cerebrospinal fluid of HTLV-I-associated myelopathy/tropical spastic paraparesis.
Journal of the neurological sciences 1990;97(2-3):183-93.
1990: Miyazaki T; Uno M; Uehira M; Kikutani H; Kishimoto T; Kimoto M; Nishimoto H; Miyazaki J; Yamamura K
Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice.
Nature 1990;345(6277):722-4.
1990: Sugita T; Totsuka T; Saito M; Yamasaki K; Taga T; Hirano T; Kishimoto T
Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis.
The Journal of experimental medicine 1990;171(6):2001-9.
1990: Akira S; Isshiki H; Sugita T; Tanabe O; Kinoshita S; Nishio Y; Nakajima T; Hirano T; Kishimoto T
A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.
The EMBO journal 1990;9(6):1897-906.
1990: Isshiki H; Akira S; Tanabe O; Nakajima T; Shimamoto T; Hirano T; Kishimoto T
Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene.
Molecular and cellular biology 1990;10(6):2757-64.
1990: Taga T; Kishimoto T
Immune and hematopoietic cell regulation: cytokines and their receptors.
Current opinion in cell biology 1990;2(2):174-80.
1990: Kikutani H; Kishimoto T
Molecular genetics and biology of two different species of Fc epsilon RII.
Research in immunology 1990;141(3):249-58.
1990: Hirano T; Taga T; Matsuda T; Hibi M; Suematsu S; Tang B; Murakami M; Kishimoto T
Interleukin 6 and its receptor in the immune response and hematopoiesis.
International journal of cell cloning 1990;8 Suppl 1():155-66; discussion 166-7.
1990: Breen E C; Rezai A R; Nakajima K; Beall G N; Mitsuyasu R T; Hirano T; Kishimoto T; Martinez-Maza O
Infection with HIV is associated with elevated IL-6 levels and production.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(2):480-4.
1990: Suematsu S; Hibi M; Sugita T; Saito M; Murakami M; Matsusaka T; Matsuda T; Hirano T; Taga T; Kishimoto T
Interleukin 6 (IL-6) and its receptor (IL-6R) in myeloma/plasmacytoma.
Current topics in microbiology and immunology 1990;166():13-22.
1990: Nakano N; Kikutani H; Kishimoto T
Differential effects of IL-2 and IL-6 on the development of three distinct precursor T-cell populations in the thymus.
Developmental immunology 1990;1(2):77-84.
1989: Hirata Y; Taga T; Hibi M; Nakano N; Hirano T; Kishimoto T
Characterization of IL-6 receptor expression by monoclonal and polyclonal antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(9):2900-6.
1989: Suematsu S; Matsuda T; Aozasa K; Akira S; Nakano N; Ohno S; Miyazaki J; Yamamura K; Hirano T; Kishimoto T
IgG1 plasmacytosis in interleukin 6 transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(19):7547-51.
1989: Yukawa K; Kikutani H; Inomoto T; Uehira M; Bin S H; Akagi K; Yamamura K; Kishimoto T
Strain dependency of B and T lymphoma development in immunoglobulin heavy chain enhancer (E mu)-myc transgenic mice.
The Journal of experimental medicine 1989;170(3):711-26.
1989: Taga T; Hibi M; Hirata Y; Yamasaki K; Yasukawa K; Matsuda T; Hirano T; Kishimoto T
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130.
Cell 1989;58(3):573-81.
1989: Kishimoto T
The biology of interleukin-6.
Blood 1989;74(1):1-10.
1989: Nishimoto N; Yoshizaki K; Tagoh H; Monden M; Kishimoto S; Hirano T; Kishimoto T
Elevation of serum interleukin 6 prior to acute phase proteins on the inflammation by surgical operation.
Clinical immunology and immunopathology 1989;50(3):399-401.
1989: Nakajima K; Martínez-Maza O; Hirano T; Breen E C; Nishanian P G; Salazar-Gonzalez J F; Fahey J L; Kishimoto T
Induction of IL-6 (B cell stimulatory factor-2/IFN-beta 2) production by HIV.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(2):531-6.
1989: Hirano T; Kishimoto T
Interleukin-6: possible implications in human diseases.
La Ricerca in clinica e in laboratorio 1989;19(1):1-10.
1989: Matsuda T; Hirano T; Nagasawa S; Kishimoto T
Identification of alpha 2-macroglobulin as a carrier protein for IL-6.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(1):148-52.
1989: Matsuda T; Yamasaki K; Taga T; Hirano T; Kishimoto T
Current concepts of B cell modulation.
International reviews of immunology 1989;5(2):97-109.
1989: Matsuda T; Suematsu S; Kawano M; Yoshizaki K; Tang B; Tanabe O; Nakajima T; Akira S; Hirano T; Kishimoto T
IL-6/BSF2 in normal and abnormal regulation of immune responses.
Annals of the New York Academy of Sciences 1989;557():466-76; discussion 476-7.
1989: Hirano T; Taga T; Yamasaki K; Matsuda T; Yasukawa K; Hirata Y; Yawata H; Tanabe O; Akira S; Kishimoto T
Molecular cloning of the cDNAs for interleukin-6/B cell stimulatory factor 2 and its receptor.
Annals of the New York Academy of Sciences 1989;557():167-78, discussion 178-80.
1989: Kikutani H; Yokota A; Uchibayashi N; Yukawa K; Tanaka T; Sugiyama K; Barsumian E L; Suemura M; Kishimoto T
Structure and function of Fc epsilon receptor II (Fc epsilon RII/CD23): a point of contact between the effector phase of allergy and B cell differentiation.
Ciba Foundation symposium 1989;147():23-31; discussion 31-5.
1989: Kishimoto T; Taga T; Yamasaki K; Matsuda T; Tang B; Muraguchi A; Horii Y; Suematsu S; Hirata Y; Yawata H
Normal and abnormal regulation of human B cell differentiation by a new cytokine, BSF2/IL-6.
Advances in experimental medicine and biology 1989;254():135-43.
1989: Taga T; Hibi M; Hirata Y; Yawata H; Natsuka S; Yasukawa K; Totsuka T; Yamasaki K; Hirano T; Kishimoto T
Interleukin-6 receptor and a unique mechanism of its signal transduction.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 2():713-22.
1989: Uehira M; Uno M; Kürner T; Kikutani H; Mori K; Inomoto T; Uede T; Miyazaki J; Nishimoto H; Kishimoto T
Development of autoimmune insulitis is prevented in E alpha d but not in A beta k NOD transgenic mice.
International immunology 1989;1(2):209-13.
1989: Hirano T; Kishimoto T
Interleukin 6 and plasma cell neoplasias.
Progress in growth factor research 1989;1(3):133-42.
1988: Tanabe O; Akira S; Kamiya T; Wong G G; Hirano T; Kishimoto T
Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(11):3875-81.
1988: Yokota A; Kikutani H; Tanaka T; Sato R; Barsumian E L; Suemura M; Kishimoto T
Two species of human Fc epsilon receptor II (Fc epsilon RII/CD23): tissue-specific and IL-4-specific regulation of gene expression.
Cell 1988;55(4):611-8.
1988: Horii Y; Muraguchi A; Suematsu S; Matsuda T; Yoshizaki K; Hirano T; Kishimoto T
Regulation of BSF-2/IL-6 production by human mononuclear cells. Macrophage-dependent synthesis of BSF-2/IL-6 by T cells.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(5):1529-35.
1988: Yamasaki K; Taga T; Hirata Y; Yawata H; Kawanishi Y; Seed B; Taniguchi T; Hirano T; Kishimoto T
Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor.
Science (New York, N.Y.) 1988;241(4867):825-8.
1988: Matsuda T; Hirano T; Kishimoto T
Establishment of an interleukin 6 (IL 6)/B cell stimulatory factor 2-dependent cell line and preparation of anti-IL 6 monoclonal antibodies.
European journal of immunology 1988;18(6):951-6.
1988: Muraguchi A; Hirano T; Tang B; Matsuda T; Horii Y; Nakajima K; Kishimoto T
The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells.
The Journal of experimental medicine 1988;167(2):332-44.
1988: Hirano T; Matsuda T; Hosoi K; Okano A; Matsui H; Kishimoto T
Absence of antiviral activity in recombinant B cell stimulatory factor 2 (BSF-2).
Immunology letters 1988;17(1):41-5.
1988: Kishimoto T; Hirano T
Molecular regulation of B lymphocyte response.
Annual review of immunology 1988;6():485-512.
1987: Hardy R R; Kishimoto T; Hayakawa K
Differentiation of B cell progenitors in vitro: generation of surface IgM+ B cells, including Ly-1 B cells, from Thy-1- asialoGM1+ cells in newborn liver.
European journal of immunology 1987;17(12):1769-74.
1987: Nakano N; Hardy R R; Kishimoto T
Identification of intrathymic T progenitor cells by expression of Thy-1, IL2 receptor and CD3.
European journal of immunology 1987;17(11):1567-71.
1987: Yasukawa K; Hirano T; Watanabe Y; Muratani K; Matsuda T; Nakai S; Kishimoto T
Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene.
The EMBO journal 1987;6(10):2939-45.
1987: Taga T; Kawanishi Y; Hardy R R; Hirano T; Kishimoto T
Receptors for B cell stimulatory factor 2. Quantitation, specificity, distribution, and regulation of their expression.
The Journal of experimental medicine 1987;166(4):967-81.
1987: Kishimoto T
B-cell stimulatory factors (BSFs): molecular structure, biological function, and regulation of expression.
Journal of clinical immunology 1987;7(5):343-55.
1987: Yukawa K; Kikutani H; Owaki H; Yamasaki K; Yokota A; Nakamura H; Barsumian E L; Hardy R R; Suemura M; Kishimoto T
A B cell-specific differentiation antigen, CD23, is a receptor for IgE (Fc epsilon R) on lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(8):2576-80.
1987: Suemura M; Kishimoto T
IgE class-specific regulatory factor(s) and Fc epsilon receptors on lymphocytes.
International reviews of immunology 1987;2(1):27-42.
1986: Kikutani H; Suemura M; Owaki H; Nakamura H; Sato R; Yamasaki K; Barsumian E L; Hardy R R; Kishimoto T
Fc epsilon receptor, a specific differentiation marker transiently expressed on mature B cells before isotype switching.
The Journal of experimental medicine 1986;164(5):1455-69.
1982: Muraguchi A; Tachibana T; Miki Y; Kuritani T; Kishi H; Kishimoto S; Yamamura Y; Kishimoto T
Depressed functions of T cells and the presence of suppressor macrophages in patients with sarcoidosis.
Clinical immunology and immunopathology 1982;23(2):189-201.
1982: Yoshizaki K; Nakagawa T; Kaieda T; Muraguchi A; Yamamura Y; Kishimoto T
Induction of proliferation and Ig production in human B leukemic cells by anti-immunoglobulins and T cell factors.
Journal of immunology (Baltimore, Md. : 1950) 1982;128(3):1296-301.
1981: Muraguchi A; Kishimoto T; Miki Y; Kuritani T; Kaieda T; Yoshizaki K; Yamamura Y
T cell-replacing factor- (TRF) induced IgG secretion in a human B blastoid cell line and demonstration of acceptors for TRF.
Journal of immunology (Baltimore, Md. : 1950) 1981;127(2):412-6.
1980: Kuritani T; Kishimoto T; Muraguchi A; Yamamura Y
In vitro immune response of human peripheral lymphocytes. VI. Distribution and characterization of precursors for PHA- and protein A-induced colony-forming B cells.
Journal of immunology (Baltimore, Md. : 1950) 1980;125(6):2633-7.
1980: Muraguchi A; Kishimoto T; Kuritani T; Yamamura Y
In vitro immune response of human peripheral lymphocytes. VII. Effect of anti-mu and anti-delta antibodies on B colony formation and detection of abnormal B cells in patients with juvenile rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950) 1980;125(6):2638-42.
1980: Muraguchi A; Kishimoto T; Kuritani T; Watanabe T; Yamamura Y
In vitro immune response of human peripheral lymphocytes. V. PHA- and protein A-induced human B colony formation and analysis of the subpopulations of B cells.
Journal of immunology (Baltimore, Md. : 1950) 1980;125(2):564-9.
1980: Saiki O; Kishimoto T; Kuritani T; Muraguchi A; Yamamura Y
In vitro induction of IgM secretion and switching to IgG production in human B leukemic cells with the help of T cells.
Journal of immunology (Baltimore, Md. : 1950) 1980;124(6):2609-14.

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