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Thomas Kissel

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

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Mice

Devices

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Microspheres

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Environmental Biodegradation

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Microscopy, Electron, Scanning

Physiology

Transfection

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Pharmaceutical Chemistry

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Co-Publications
Name
18
Bakowsky, Udo
16
Fischer, Dagmar
15
Wittmar, Matthias
14
Mao, Shirui
13
Merdan, Thomas
13
Petersen, Holger
12
Schmehl, Thomas
12
Kunath, Klaus
12
Gessler, Tobias
11
Unger, Florian
10
Schaper, Andreas
9
Seeger, Werner
9
Germershaus, Oliver
8
Merkel, Olivia
8
Neu, Michael

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Publications

TOP 3
Jintapattanakit Anchalee; Junyaprasert Varaporn Buraphacheep; Kissel Thomas
The role of mucoadhesion of trimethyl chitosan and PEGylated trimethyl chitosan nanocomplexes in insulin uptake.
Nguyen Juliane; Reul Regina; Betz Thomas; Dayyoub Eyas; Schmehl Thomas; Gessler Tobias; Bakowsky Udo; Seeger Werner; Kissel Thomas
Nanocomposites of lung surfactant and biodegradable cationic nanoparticles improve transfection efficiency to lung cells.
Reul Regina; Nguyen Juliane; Kissel Thomas
Amine-modified hyperbranched polyesters as non-toxic, biodegradable gene delivery systems.

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All Publications

2009: Jintapattanakit Anchalee; Junyaprasert Varaporn Buraphacheep; Kissel Thomas
The role of mucoadhesion of trimethyl chitosan and PEGylated trimethyl chitosan nanocomplexes in insulin uptake.
Journal of pharmaceutical sciences 2009;98(12):4818-30.
2009: Nguyen Juliane; Reul Regina; Betz Thomas; Dayyoub Eyas; Schmehl Thomas; Gessler Tobias; Bakowsky Udo; Seeger Werner; Kissel Thomas
Nanocomposites of lung surfactant and biodegradable cationic nanoparticles improve transfection efficiency to lung cells.
Journal of controlled release : official journal of the Controlled Release Society 2009;140(1):47-54.
2009: Reul Regina; Nguyen Juliane; Kissel Thomas
Amine-modified hyperbranched polyesters as non-toxic, biodegradable gene delivery systems.
Biomaterials 2009;30(29):5815-24.
2009: Merkel Olivia M; Mintzer Meredith A; Sitterberg Johannes; Bakowsky Udo; Simanek Eric E; Kissel Thomas
Triazine dendrimers as nonviral gene delivery systems: effects of molecular structure on biological activity.
Bioconjugate chemistry 2009;20(9):1799-806.
2009: Kleemann Elke; Jekel Norman; Dailey Lea Ann; Roesler Susanne; Fink Ludger; Weissmann Norbert; Schermuly Ralph; Gessler Tobias; Schmehl Thomas; Roberts Clive J; Seeger Werner; Kissel Thomas
Enhanced gene expression and reduced toxicity in mice using polyplexes of low-molecular-weight poly(ethylene imine) for pulmonary gene delivery.
Journal of drug targeting 2009;17(8):638-51.
2009: Merkel Olivia M; Librizzi Damiano; Pfestroff Andreas; Schurrat Tino; Buyens Kevin; Sanders Niek N; De Smedt Stefaan C; Béhé Martin; Kissel Thomas
Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging.
Journal of controlled release : official journal of the Controlled Release Society 2009;138(2):148-59.
2009: Merkel Olivia M; Beyerle Andrea; Librizzi Damiano; Pfestroff Andreas; Behr Thomas M; Sproat Brian; Barth Peter J; Kissel Thomas
Nonviral siRNA delivery to the lung: investigation of PEG-PEI polyplexes and their in vivo performance.
Molecular pharmaceutics 2009;6(4):1246-60.
2009: Trapani Adriana; Sitterberg Johannes; Bakowsky Udo; Kissel Thomas
The potential of glycol chitosan nanoparticles as carrier for low water soluble drugs.
International journal of pharmaceutics 2009;375(1-2):97-106.
2009: Merkel Olivia M; Germershaus Oliver; Wada Carol K; Tarcha Peter J; Merdan Thomas; Kissel Thomas
Integrin alphaVbeta3 targeted gene delivery using RGD peptidomimetic conjugates with copolymers of PEGylated poly(ethylene imine).
Bioconjugate chemistry 2009;20(6):1270-80.
2009: Malek Anastasia; Merkel Olivia; Fink Ludger; Czubayko Frank; Kissel Thomas; Aigner Achim
In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(-PEG)/siRNA complexes.
Toxicology and applied pharmacology 2009;236(1):97-108.
2009: Beck-Broichsitter Moritz; Gauss Julia; Packhaeuser Claudia B; Lahnstein Kerstin; Schmehl Thomas; Seeger Werner; Kissel Thomas; Gessler Tobias
Pulmonary drug delivery with aerosolizable nanoparticles in an ex vivo lung model.
International journal of pharmaceutics 2009;367(1-2):169-78.
2009: Merkel Olivia M; Librizzi Damiano; Pfestroff Andreas; Schurrat Tino; Béhé Martin; Kissel Thomas
In vivo SPECT and real-time gamma camera imaging of biodistribution and pharmacokinetics of siRNA delivery using an optimized radiolabeling and purification procedure.
Bioconjugate chemistry 2009;20(1):174-82.
2008: Nguyen Juliane; Steele Terry W J; Merkel Olivia; Reul Regina; Kissel Thomas
Fast degrading polyesters as siRNA nano-carriers for pulmonary gene therapy.
Journal of controlled release : official journal of the Controlled Release Society 2008;132(3):243-51.
2008: Nguyen Juliane; Xie Xiulan; Neu Michael; Dumitrascu Rio; Reul Regina; Sitterberg Johannes; Bakowsky Udo; Schermuly Ralph; Fink Ludger; Schmehl Thomas; Gessler Tobias; Seeger Werner; Kissel Thomas
Effects of cell-penetrating peptides and pegylation on transfection efficiency of polyethylenimine in mouse lungs.
The journal of gene medicine 2008;10(11):1236-46.
2008: Mei Dan; Mao Shirui; Sun Wei; Wang Yanjun; Kissel Thomas
Effect of chitosan structure properties and molecular weight on the intranasal absorption of tetramethylpyrazine phosphate in rats.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;70(3):874-81.
2008: Jintapattanakit Anchalee; Mao Shirui; Kissel Thomas; Junyaprasert Varaporn Buraphacheep
Physicochemical properties and biocompatibility of N-trimethyl chitosan: effect of quaternization and dimethylation.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;70(2):563-71.
2008: Rytting Erik; Nguyen Juliane; Wang Xiaoying; Kissel Thomas
Biodegradable polymeric nanocarriers for pulmonary drug delivery.
Expert opinion on drug delivery 2008;5(6):629-39.
2008: Sun Wei; Mao Shirui; Mei Dan; Kissel Thomas
Self-assembled polyelectrolyte nanocomplexes between chitosan derivatives and enoxaparin.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;69(2):417-25.
2008: Unger Florian; Wittmar Matthias; Morell Frank; Kissel Thomas
Branched polyesters based on poly[vinyl-3-(dialkylamino)alkylcarbamate-co-vinyl acetate-co-vinyl alcohol]-graft-poly(D,L-lactide-co-glycolide): effects of polymer structure on in vitro degradation behaviour.
Biomaterials 2008;29(13):2007-14.
2008: Cai Cuifang; Bakowsky Udo; Rytting Erik; Schaper Andreas K; Kissel Thomas
Charged nanoparticles as protein delivery systems: a feasibility study using lysozyme as model protein.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;69(1):31-42.
2008: Maretschek Sascha; Greiner Andreas; Kissel Thomas
Electrospun biodegradable nanofiber nonwovens for controlled release of proteins.
Journal of controlled release : official journal of the Controlled Release Society 2008;127(2):180-7.
2008: Mao Shirui; Shi Yi; Li Luk; Xu Jing; Schaper Andreas; Kissel Thomas
Effects of process and formulation parameters on characteristics and internal morphology of poly(d,l-lactide-co-glycolide) microspheres formed by the solvent evaporation method.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;68(2):214-23.
2008: Germershaus Oliver; Neu Michael; Behe Martin; Kissel Thomas
HER2 targeted polyplexes: the effect of polyplex composition and conjugation chemistry on in vitro and in vivo characteristics.
Bioconjugate chemistry 2008;19(1):244-53.
2008: Germershaus Oliver; Mao Shirui; Sitterberg Johannes; Bakowsky Udo; Kissel Thomas
Gene delivery using chitosan, trimethyl chitosan or polyethylenglycol-graft-trimethyl chitosan block copolymers: establishment of structure-activity relationships in vitro.
Journal of controlled release : official journal of the Controlled Release Society 2008;125(2):145-54.
2007: Neu Michael; Germershaus Oliver; Behe Martin; Kissel Thomas
Bioreversibly crosslinked polyplexes of PEI and high molecular weight PEG show extended circulation times in vivo.
Journal of controlled release : official journal of the Controlled Release Society 2007;124(1-2):69-80.
2007: Mao Shirui; Augsten Christian; Mäder Karsten; Kissel Thomas
Characterization of chitosan and its derivatives using asymmetrical flow field-flow-fractionation: a comparison with traditional methods.
Journal of pharmaceutical and biomedical analysis 2007;45(5):736-41.
2007: Packhaeuser C B; Kissel T
On the design of in situ forming biodegradable parenteral depot systems based on insulin loaded dialkylaminoalkyl-amine-poly(vinyl alcohol)-g-poly(lactide-co-glycolide) nanoparticles.
Journal of controlled release : official journal of the Controlled Release Society 2007;123(2):131-40.
2007: Jintapattanakit Anchalee; Junyaprasert Varaporn B; Mao Shirui; Sitterberg Johannes; Bakowsky Udo; Kissel Thomas
Peroral delivery of insulin using chitosan derivatives: a comparative study of polyelectrolyte nanocomplexes and nanoparticles.
International journal of pharmaceutics 2007;342(1-2):240-9.
2007: Westedt Ulrich; Kalinowski Marc; Wittmar Matthias; Merdan Thomas; Unger Florian; Fuchs Jutta; Schäller Susann; Bakowsky Udo; Kissel Thomas
Poly(vinyl alcohol)-graft-poly(lactide-co-glycolide) nanoparticles for local delivery of paclitaxel for restenosis treatment.
Journal of controlled release : official journal of the Controlled Release Society 2007;119(1):41-51.
2007: Simon Michael; Behrens Isabel; Dailey Lea Anne; Wittmar Matthias; Kissel Thomas
Nanosized insulin-complexes based on biodegradable amine-modified graft polyesters poly[vinyl-3-(diethylamino)-propylcarbamate-co-(vinyl acetate)-co-(vinyl alcohol)]-graft-poly(L-lactic acid): protection against enzymatic degradation, interaction with Caco-2 cell monolayers, peptide transport and cytotoxicity.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2007;66(2):165-72.
2007: Neu Michael; Germershaus Oliver; Mao Shirui; Voigt Karl-Heinz; Behe Martin; Kissel Thomas
Crosslinked nanocarriers based upon poly(ethylene imine) for systemic plasmid delivery: in vitro characterization and in vivo studies in mice.
Journal of controlled release : official journal of the Controlled Release Society 2007;118(3):370-80.
2007: Mao Shirui; Xu Jing; Cai Cuifang; Germershaus Oliver; Schaper Andreas; Kissel Thomas
Effect of WOW process parameters on morphology and burst release of FITC-dextran loaded PLGA microspheres.
International journal of pharmaceutics 2007;334(1-2):137-48.
2007: Unger F; Wittmar M; Kissel T
Branched polyesters based on poly[vinyl-3-(dialkylamino)alkylcarbamate-co-vinyl acetate-co-vinyl alcohol]-graft-poly(d,l-lactide-co-glycolide): effects of polymer structure on cytotoxicity.
Biomaterials 2007;28(9):1610-9.
2007: Kleemann Elke; Schmehl Thomas; Gessler Tobias; Bakowsky Udo; Kissel Thomas; Seeger Werner
Iloprost-containing liposomes for aerosol application in pulmonary arterial hypertension: formulation aspects and stability.
Pharmaceutical research 2007;24(2):277-87.
2007: Unger F; Westedt U; Hanefeld P; Wombacher R; Zimmermann S; Greiner A; Ausborn M; Kissel T
Poly(ethylene carbonate): a thermoelastic and biodegradable biomaterial for drug eluting stent coatings?
Journal of controlled release : official journal of the Controlled Release Society 2007;117(3):312-21.
2006: Neu Michael; Sitterberg Johannes; Bakowsky Udo; Kissel Thomas
Stabilized nanocarriers for plasmids based upon cross-linked poly(ethylene imine).
Biomacromolecules 2006;7(12):3428-38.
2006: Anabousi Samah; Kleemann Elke; Bakowsky Udo; Kissel Thomas; Schmehl Thomas; Gessler Tobias; Seeger Werner; Lehr Claus-Michael; Ehrhardt Carsten
Effect of PEGylation on the stability of liposomes during nebulisation and in lung surfactant.
Journal of nanoscience and nanotechnology 2006;6(9-10):3010-6.
2006: Mao Shirui; Neu Michael; Germershaus Oliver; Merkel Olivia; Sitterberg Johannes; Bakowsky Udo; Kissel Thomas
Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/SiRNA polyplexes.
Bioconjugate chemistry 2006;17(5):1209-18.
2006: Germershaus Oliver; Merdan Thomas; Bakowsky Udo; Behe Martin; Kissel Thomas
Trastuzumab-polyethylenimine-polyethylene glycol conjugates for targeting Her2-expressing tumors.
Bioconjugate chemistry 2006;17(5):1190-9.
2006: Schnieders Julia; Gbureck Uwe; Thull Roger; Kissel Thomas
Controlled release of gentamicin from calcium phosphate-poly(lactic acid-co-glycolic acid) composite bone cement.
Biomaterials 2006;27(23):4239-49.
2006: Dailey L A; Jekel N; Fink L; Gessler T; Schmehl T; Wittmar M; Kissel T; Seeger W
Investigation of the proinflammatory potential of biodegradable nanoparticle drug delivery systems in the lung.
Toxicology and applied pharmacology 2006;215(1):100-8.
2006: Hanefeld Phillip; Westedt Ullrich; Wombacher Ralf; Kissel Thomas; Schaper Andreas; Wendorff Joachim H; Greiner Andreas
Coating of poly(p-xylylene) by PLA-PEO-PLA triblock copolymers with excellent polymer-polymer adhesion for stent applications.
Biomacromolecules 2006;7(7):2086-90.
2006: Mao Shirui; Bakowsky Udo; Jintapattanakit Anchalee; Kissel Thomas
Self-assembled polyelectrolyte nanocomplexes between chitosan derivatives and insulin.
Journal of pharmaceutical sciences 2006;95(5):1035-48.
2006: Oster Christine G; Wittmar Matthias; Bakowsky Udo; Kissel Thomas
DNA nano-carriers from biodegradable cationic branched polyesters are formed by a modified solvent displacement method.
Journal of controlled release : official journal of the Controlled Release Society 2006;111(3):371-81.
2006: Westedt Ulrich; Wittmar Matthias; Hellwig Michael; Hanefeld Phillip; Greiner Andreas; Schaper Andreas K; Kissel Thomas
Paclitaxel releasing films consisting of poly(vinyl alcohol)-graft-poly(lactide-co-glycolide) and their potential as biodegradable stent coatings.
Journal of controlled release : official journal of the Controlled Release Society 2006;111(1-2):235-46.
2005: Kleemann E; Neu M; Jekel N; Fink L; Schmehl T; Gessler T; Seeger W; Kissel T
Nano-carriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG-PEI.
Journal of controlled release : official journal of the Controlled Release Society 2005;109(1-3):299-316.
2005: Mao Shirui; Germershaus Oliver; Fischer Dagmar; Linn Thomas; Schnepf Robert; Kissel Thomas
Uptake and transport of PEG-graft-trimethyl-chitosan copolymer-insulin nanocomplexes by epithelial cells.
Pharmaceutical research 2005;22(12):2058-68.
2005: Wittmar Matthias; Ellis James S; Morell Frank; Unger Florian; Schumacher Jeanette Christine; Roberts Clive J; Tendler Saul J B; Davies Martyn C; Kissel Thomas
Biophysical and transfection studies of an amine-modified poly(vinyl alcohol) for gene delivery.
Bioconjugate chemistry 2005;16(6):1390-8.
2005: Simon Michael; Wittmar Matthias; Kissel Thomas; Linn Thomas
Insulin containing nanocomplexes formed by self-assembly from biodegradable amine-modified poly(vinyl alcohol)-graft-poly(L-lactide): bioavailability and nasal tolerability in rats.
Pharmaceutical research 2005;22(11):1879-86.
2005: Mao Shirui; Shuai Xintao; Unger Florian; Wittmar Matthias; Xie Xiulan; Kissel Thomas
Synthesis, characterization and cytotoxicity of poly(ethylene glycol)-graft-trimethyl chitosan block copolymers.
Biomaterials 2005;26(32):6343-56.
2005: Neu Michael; Fischer Dagmar; Kissel Thomas
Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives.
The journal of gene medicine 2005;7(8):992-1009.
2005: Merdan Thomas; Kunath Klaus; Petersen Holger; Bakowsky Udo; Voigt Karl Heinz; Kopecek Jindrich; Kissel Thomas
PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice.
Bioconjugate chemistry 2005;16(4):785-92.
2005: Hann Evelin; Reinartz Silke; Clare Susan E; Passow Sebastian; Kissel Thomas; Wagner Uwe
Development of a delivery system for the continuous endogenous release of an anti-idiotypic antibody against ovarian carcinoma.
Hybridoma (2005) 2005;24(3):133-40.
2005: Oster C G; Kissel T
Comparative study of DNA encapsulation into PLGA microparticles using modified double emulsion methods and spray drying techniques.
Journal of microencapsulation 2005;22(3):235-44.
2005: Oster C G; Kim N; Grode L; Barbu-Tudoran L; Schaper A K; Kaufmann S H E; Kissel T
Cationic microparticles consisting of poly(lactide-co-glycolide) and polyethylenimine as carriers systems for parental DNA vaccination.
Journal of controlled release : official journal of the Controlled Release Society 2005;104(2):359-77.
2005: Zeng Jun; Aigner Achim; Czubayko Frank; Kissel Thomas; Wendorff Joachim H; Greiner Andreas
Poly(vinyl alcohol) nanofibers by electrospinning as a protein delivery system and the retardation of enzyme release by additional polymer coatings.
Biomacromolecules 2005;6(3):1484-8.
2005: Shuai Xintao; Merdan Thomas; Unger Florian; Kissel Thomas
Supramolecular gene delivery vectors showing enhanced transgene expression and good biocompatibility.
Bioconjugate chemistry 2005;16(2):322-9.
2005: Dailey Lea Ann; Wittmar Matthias; Kissel Thomas
The role of branched polyesters and their modifications in the development of modern drug delivery vehicles.
Journal of controlled release : official journal of the Controlled Release Society 2005;101(1-3):137-49.
2004: Kleemann E; Dailey L A; Abdelhady H G; Gessler T; Schmehl T; Roberts C J; Davies M C; Seeger W; Kissel T
Modified polyethylenimines as non-viral gene delivery systems for aerosol gene therapy: investigations of the complex structure and stability during air-jet and ultrasonic nebulization.
Journal of controlled release : official journal of the Controlled Release Society 2004;100(3):437-50.
2004: Dailey L A; Kleemann E; Merdan T; Petersen H; Schmehl T; Gessler T; Hänze J; Seeger W; Kissel T
Modified polyethylenimines as non viral gene delivery systems for aerosol therapy: effects of nebulization on cellular uptake and transfection efficiency.
Journal of controlled release : official journal of the Controlled Release Society 2004;100(3):425-36.
2004: Fischer Dagmar; Osburg Berit; Petersen Holger; Kissel Thomas; Bickel Ulrich
Effect of poly(ethylene imine) molecular weight and pegylation on organ distribution and pharmacokinetics of polyplexes with oligodeoxynucleotides in mice.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(9):983-92.
2004: Packhaeuser C B; Schnieders J; Oster C G; Kissel T
In situ forming parenteral drug delivery systems: an overview.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2004;58(2):445-55.
2004: Mao Shirui; Shuai Xintao; Unger Florian; Simon Michael; Bi Dianzhou; Kissel Thomas
The depolymerization of chitosan: effects on physicochemical and biological properties.
International journal of pharmaceutics 2004;281(1-2):45-54.
2004: Fischer Dagmar; Dautzenberg Herbert; Kunath Klaus; Kissel Thomas
Poly(diallyldimethylammonium chlorides) and their N-methyl-N-vinylacetamide copolymer-based DNA-polyplexes: role of molecular weight and charge density in complex formation, stability, and in vitro activity.
International journal of pharmaceutics 2004;280(1-2):253-69.
2004: Simon M; Wittmar M; Bakowsky U; Kissel T
Self-assembling nanocomplexes from insulin and water-soluble branched polyesters, poly[(vinyl-3-(diethylamino)- propylcarbamate-co-(vinyl acetate)-co-(vinyl alcohol)]-graft- poly(L-lactic acid): a novel carrier for transmucosal delivery of peptides.
Bioconjugate chemistry 2004;15(4):841-9.
2004: Brus Carola; Petersen Holger; Aigner Achim; Czubayko Frank; Kissel Thomas
Physicochemical and biological characterization of polyethylenimine-graft-poly(ethylene glycol) block copolymers as a delivery system for oligonucleotides and ribozymes.
Bioconjugate chemistry 2004;15(4):677-84.
2004: Schliecker Gesine; Schmidt Carsten; Fuchs Stefan; Kissel Thomas
Characterization and in vitro degradation of poly(2,3-(1,4-diethyl tartrate)-co-2,3-isopropyliden tartrate).
Journal of controlled release : official journal of the Controlled Release Society 2004;98(1):11-23.
2004: Westedt Ulrich; Barbu-Tudoran Lucian; Schaper Andreas K; Kalinowski Marc; Alfke Heiko; Kissel Thomas
Effects of different application parameters on penetration characteristics and arterial vessel wall integrity after local nanoparticle delivery using a porous balloon catheter.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2004;58(1):161-8.
2004: Behrens Isabel; Kamm Walter; Dantzig Anne H; Kissel Thomas
Variation of peptide transporter (PepT1 and HPT1) expression in Caco-2 cells as a function of cell origin.
Journal of pharmaceutical sciences 2004;93(7):1743-54.
2004: Oster Christine G; Wittmar Matthias; Unger Florian; Barbu-Tudoran Lucian; Schaper Andreas K; Kissel Thomas
Design of amine-modified graft polyesters for effective gene delivery using DNA-loaded nanoparticles.
Pharmaceutical research 2004;21(6):927-31.
2004: Winzenburg Gesine; Schmidt Carsten; Fuchs Stefan; Kissel Thomas
Biodegradable polymers and their potential use in parenteral veterinary drug delivery systems.
Advanced drug delivery reviews 2004;56(10):1453-66.
2004: Shuai Xintao; Merdan Thomas; Schaper Andreas K; Xi Fu; Kissel Thomas
Core-cross-linked polymeric micelles as paclitaxel carriers.
Bioconjugate chemistry 2004;15(3):441-8.
2004: Brus Carola; Petersen Holger; Aigner Achim; Czubayko Frank; Kissel Thomas
Efficiency of polyethylenimines and polyethylenimine-graft-poly (ethylene glycol) block copolymers to protect oligonucleotides against enzymatic degradation.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2004;57(3):427-30.
2004: Weidenauer U; Bodmer D; Kissel T
Microencapsulation of hydrophilic drug substances using biodegradable polyesters. Part II: Implants allowing controlled drug release--a feasibility study using bisphosphonates.
Journal of microencapsulation 2004;21(2):137-49.
2004: Brus Carola; Kleemann Elke; Aigner Achim; Czubayko Frank; Kissel Thomas
Stabilization of oligonucleotide-polyethylenimine complexes by freeze-drying: physicochemical and biological characterization.
Journal of controlled release : official journal of the Controlled Release Society 2004;95(1):119-31.
2004: Schliecker Gesine; Schmidt Carsten; Fuchs Stefan; Ehinger Andreas; Sandow Jürgen; Kissel Thomas
In vitro and in vivo correlation of buserelin release from biodegradable implants using statistical moment analysis.
Journal of controlled release : official journal of the Controlled Release Society 2004;94(1):25-37.
2003: Dailey L A; Kleemann E; Wittmar M; Gessler T; Schmehl T; Roberts C; Seeger W; Kissel T
Surfactant-free, biodegradable nanoparticles for aerosol therapy based on the branched polyesters, DEAPA-PVAL-g-PLGA.
Pharmaceutical research 2003;20(12):2011-20.
2003: Dadsetan M; Christenson E M; Unger F; Ausborn M; Kissel T; Hiltner A; Anderson J M
In vivo biocompatibility and biodegradation of poly(ethylene carbonate).
Journal of controlled release : official journal of the Controlled Release Society 2003;93(3):259-70.
2003: Schliecker Gesine; Schmidt Carsten; Fuchs Stefan; Wombacher Ralf; Kissel Thomas
Hydrolytic degradation of poly(lactide-co-glycolide) films: effect of oligomers on degradation rate and crystallinity.
International journal of pharmaceutics 2003;266(1-2):39-49.
2003: Merdan Thomas; Callahan Jon; Petersen Holger; Kunath Klaus; Bakowsky Udo; Kopecková Pavla; Kissel Thomas; Kopecek Jindrich
Pegylated polyethylenimine-Fab' antibody fragment conjugates for targeted gene delivery to human ovarian carcinoma cells.
Bioconjugate chemistry 2003;14(5):989-96.
2003: Schliecker Gesine; Schmidt Carsten; Fuchs Stefan; Kissel Thomas
Characterization of a homologous series of D,L-lactic acid oligomers; a mechanistic study on the degradation kinetics in vitro.
Biomaterials 2003;24(21):3835-44.
2003: Behrens Isabel; Kissel Thomas
Do cell culture conditions influence the carrier-mediated transport of peptides in Caco-2 cell monolayers?
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2003;19(5):433-42.
2003: Weidenauer U; Bodmer D; Kissel T
Microencapsulation of hydrophilic drug substances using biodegradable polyesters. Part I: evaluation of different techniques for the encapsulation of pamidronate di-sodium salt.
Journal of microencapsulation 2003;20(4):509-24.
2003: Kunath Klaus; Merdan Thomas; Hegener Oliver; Häberlein Hanns; Kissel Thomas
Integrin targeting using RGD-PEI conjugates for in vitro gene transfer.
The journal of gene medicine 2003;5(7):588-99.
2003: Kunath Klaus; von Harpe Anke; Fischer Dagmar; Petersen Holger; Bickel Ulrich; Voigt Karlheinz; Kissel Thomas
Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine.
Journal of controlled release : official journal of the Controlled Release Society 2003;89(1):113-25.
2003: Fischer Dagmar; Li Youxin; Ahlemeyer Barbara; Krieglstein Josef; Kissel Thomas
In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis.
Biomaterials 2003;24(7):1121-31.
2003: Kunath Klaus; von Harpe Anke; Fischer Dagmar; Kissel Thomas
Galactose-PEI-DNA complexes for targeted gene delivery: degree of substitution affects complex size and transfection efficiency.
Journal of controlled release : official journal of the Controlled Release Society 2003;88(1):159-72.
2003: Dailey Lea Ann; Schmehl Thomas; Gessler Tobias; Wittmar Matthias; Grimminger Friedrich; Seeger Werner; Kissel Thomas
Nebulization of biodegradable nanoparticles: impact of nebulizer technology and nanoparticle characteristics on aerosol features.
Journal of controlled release : official journal of the Controlled Release Society 2003;86(1):131-44.
2002: Brus Carola; Santi Patrizia; Colombo Paolo; Kissel Thomas
Distribution and quantification of polyethylenimine oligodeoxynucleotide complexes in human skin after iontophoretic delivery using confocal scanning laser microscopy.
Journal of controlled release : official journal of the Controlled Release Society 2002;84(3):171-81.
2002: Aigner A; Fischer D; Merdan T; Brus C; Kissel T; Czubayko F
Delivery of unmodified bioactive ribozymes by an RNA-stabilizing polyethylenimine (LMW-PEI) efficiently down-regulates gene expression.
Gene therapy 2002;9(24):1700-7.
2002: Fischer Dagmar; von Harpe Anke; Kunath Klaus; Petersen Holger; Li Youxin; Kissel Thomas
Copolymers of ethylene imine and N-(2-hydroxyethyl)-ethylene imine as tools to study effects of polymer structure on physicochemical and biological properties of DNA complexes.
Bioconjugate chemistry 2002;13(5):1124-33.
2002: Petersen Holger; Kunath Klaus; Martin Alison L; Stolnik Snjezana; Roberts Clive J; Davies Martyn C; Kissel Thomas
Star-shaped poly(ethylene glycol)-block-polyethylenimine copolymers enhance DNA condensation of low molecular weight polyethylenimines.
Biomacromolecules 2002;3(5):926-36.
2002: Merdan Thomas; Kopecek Jindrich; Kissel Thomas
Prospects for cationic polymers in gene and oligonucleotide therapy against cancer.
Advanced drug delivery reviews 2002;54(5):715-58.
2002: Behrens Isabel; Pena Ana Isabel Vila; Alonso Maria José; Kissel Thomas
Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: the effect of mucus on particle adsorption and transport.
Pharmaceutical research 2002;19(8):1185-93.
2002: Jung Tobias; Kamm Walter; Breitenbach Armin; Klebe Gerhard; Kissel Thomas
Loading of tetanus toxoid to biodegradable nanoparticles from branched poly(sulfobutyl-polyvinyl alcohol)-g-(lactide-co-glycolide) nanoparticles by protein adsorption: a mechanistic study.
Pharmaceutical research 2002;19(8):1105-13.
2002: Petersen Holger; Fechner Petra M; Martin Alison L; Kunath Klaus; Stolnik Snjezana; Roberts Clive J; Fischer Dagmar; Davies Martyn C; Kissel Thomas
Polyethylenimine-graft-poly(ethylene glycol) copolymers: influence of copolymer block structure on DNA complexation and biological activities as gene delivery system.
Bioconjugate chemistry 2002;13(4):845-54.
2002: Petersen Holger; Merdan Thomas; Kunath Klaus; Fischer Dagmar; Kissel Thomas
Poly(ethylenimine-co-L-lactamide-co-succinamide): a biodegradable polyethylenimine derivative with an advantageous pH-dependent hydrolytic degradation for gene delivery.
Bioconjugate chemistry 2002;13(4):812-21.
2002: Kunath Klaus; von Harpe Anke; Petersen Holger; Fischer Dagmar; Voigt Karlheinz; Kissel Thomas; Bickel Ulrich
The structure of PEG-modified poly(ethylene imines) influences biodistribution and pharmacokinetics of their complexes with NF-kappaB decoy in mice.
Pharmaceutical research 2002;19(6):810-7.
2002: Jung Tobias; Koneberg Regina; Hungerer Klaus D; Kissel Thomas
Tetanus toxoid microspheres consisting of biodegradable poly(lactide-co-glycolide)- and ABA-triblock-copolymers: immune response in mice.
International journal of pharmaceutics 2002;234(1-2):75-90.
2002: Merdan Thomas; Kunath Klaus; Fischer Dagmar; Kopecek Jindrich; Kissel Thomas
Intracellular processing of poly(ethylene imine)/ribozyme complexes can be observed in living cells by using confocal laser scanning microscopy and inhibitor experiments.
Pharmaceutical research 2002;19(2):140-6.
2002: Kissel Thomas; Li Youxin; Unger Florian
ABA-triblock copolymers from biodegradable polyester A-blocks and hydrophilic poly(ethylene oxide) B-blocks as a candidate for in situ forming hydrogel delivery systems for proteins.
Advanced drug delivery reviews 2002;54(1):99-134.
2002: Westedt Ulrich; Barbu-Tudoran Lucian; Schaper Andreas K; Kalinowski Marc; Alfke Heiko; Kissel Thomas
Deposition of nanoparticles in the arterial vessel by porous balloon catheters: localization by confocal laser scanning microscopy and transmission electron microscopy.
AAPS pharmSci 2002;4(4):E41.
2001: Behrens I; Stenberg P; Artursson P; Kissel T
Transport of lipophilic drug molecules in a new mucus-secreting cell culture model based on HT29-MTX cells.
Pharmaceutical research 2001;18(8):1138-45.
2001: Kamm W; Hauptmann J; Behrens I; Stürzebecher J; Dullweber F; Gohlke H; Stubbs M; Klebe G; Kissel T
Transport of peptidomimetic thrombin inhibitors with a 3-amidino-phenylalanine structure: permeability and efflux mechanism in monolayers of a human intestinal cell line (Caco-2).
Pharmaceutical research 2001;18(8):1110-8.
2001: Fischer D; Bieber T; Brüsselbach S; Elsässer H; Kissel T
Cationized human serum albumin as a non-viral vector system for gene delivery? Characterization of complex formation with plasmid DNA and transfection efficiency.
International journal of pharmaceutics 2001;225(1-2):97-111.
2001: Fischer D; Kissel T
Histochemical characterization of primary capillary endothelial cells from porcine brains using monoclonal antibodies and fluorescein isothiocyanate-labelled lectins: implications for drug delivery.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2001;52(1):1-11.
2001: Witt C; Kissel T
Morphological characterization of microspheres, films and implants prepared from poly(lactide-co-glycolide) and ABA triblock copolymers: is the erosion controlled by degradation, swelling or diffusion?
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2001;51(3):171-81.
2001: Frauke Pistel K; Breitenbach A; Zange-Volland R; Kissel T
Brush-like branched biodegradable polyesters, part III. Protein release from microspheres of poly(vinyl alcohol)-graft-poly(D,L-lactic-co-glycolic acid).
Journal of controlled release : official journal of the Controlled Release Society 2001;73(1):7-20.
2001: Jung T; Kamm W; Breitenbach A; Hungerer K D; Hundt E; Kissel T
Tetanus toxoid loaded nanoparticles from sulfobutylated poly(vinyl alcohol)-graft-poly(lactide-co-glycolide): evaluation of antibody response after oral and nasal application in mice.
Pharmaceutical research 2001;18(3):352-60.
2000: von Harpe A; Petersen H; Li Y; Kissel T
Characterization of commercially available and synthesized polyethylenimines for gene delivery.
Journal of controlled release : official journal of the Controlled Release Society 2000;69(2):309-22.
2000: Ahlemeyer B; Fischer D; Kissel T; Krieglstein J
Staurosporine-induced apoptosis in cultured chick embryonic neurons is reduced by polyethylenimine of low molecular weight used as a coating substrate.
Neuroscience research 2000;37(4):245-53.
2000: Pistel K F; Kissel T
Effects of salt addition on the microencapsulation of proteins using W/O/W double emulsion technique.
Journal of microencapsulation 2000;17(4):467-83.
2000: Jung T; Kamm W; Breitenbach A; Kaiserling E; Xiao J X; Kissel T
Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake?
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2000;50(1):147-60.
2000: Jung T; Breitenbach A; Kissel T
Sulfobutylated poly(vinyl alcohol)-graft-poly(lactide-co-glycolide)s facilitate the preparation of small negatively charged biodegradable nanospheres.
Journal of controlled release : official journal of the Controlled Release Society 2000;67(2-3):157-69.
2000: Kamm W; Jonczyk A; Jung T; Luckenbach G; Raddatz P; Kissel T
Evaluation of absorption enhancement for a potent cyclopeptidic alpha(nu)beta(3)-antagonist in a human intestinal cell line (Caco-2).
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;10(3):205-14.
2000: Witt C; Mäder K; Kissel T
The degradation, swelling and erosion properties of biodegradable implants prepared by extrusion or compression moulding of poly(lactide-co-glycolide) and ABA triblock copolymers.
Biomaterials 2000;21(9):931-8.
2000: Breitenbach A; Li Y X; Kissel T
Branched biodegradable polyesters for parenteral drug delivery systems.
Journal of controlled release : official journal of the Controlled Release Society 2000;64(1-3):167-78.
2000: Breitenbach A; Mohr D; Kissel T
Biodegradable semi-crystalline comb polyesters influence the microsphere production by means of a supercritical fluid extraction technique (ASES).
Journal of controlled release : official journal of the Controlled Release Society 2000;63(1-2):53-68.
1999: Kamm W; Raddatz P; Gante J; Kissel T
Prodrug approach for alphaIIbbeta3-peptidomimetic antagonists to enhance their transport in monolayers of a human intestinal cell line (Caco-2): comparison of in vitro and in vivo data.
Pharmaceutical research 1999;16(10):1527-33.
1999: Fischer D; Bieber T; Li Y; Elsässer H P; Kissel T
A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity.
Pharmaceutical research 1999;16(8):1273-9.
1999: Bittner B; Witt C; Mäder K; Kissel T
Degradation and protein release properties of microspheres prepared from biodegradable poly(lactide-co-glycolide) and ABA triblock copolymers: influence of buffer media on polymer erosion and bovine serum albumin release.
Journal of controlled release : official journal of the Controlled Release Society 1999;60(2-3):297-309.
1999: Pistel K F; Bittner B; Koll H; Winter G; Kissel T
Biodegradable recombinant human erythropoietin loaded microspheres prepared from linear and star-branched block copolymers: influence of encapsulation technique and polymer composition on particle characteristics.
Journal of controlled release : official journal of the Controlled Release Society 1999;59(3):309-25.
1999: Altenburger R; Kissel T
The human keratinocyte cell line HaCaT: an in vitro cell culture model for keratinocyte testosterone metabolism.
Pharmaceutical research 1999;16(5):766-71.
1999: Bittner B; Kissel T
Ultrasonic atomization for spray drying: a versatile technique for the preparation of protein loaded biodegradable microspheres.
Journal of microencapsulation 1999;16(3):325-41.
1999: Bittner B; Mäder K; Kroll C; Borchert H H; Kissel T
Tetracycline-HCl-loaded poly(DL-lactide-co-glycolide) microspheres prepared by a spray drying technique: influence of gamma-irradiation on radical formation and polymer degradation.
Journal of controlled release : official journal of the Controlled Release Society 1999;59(1):23-32.
1999: Hilbert A K; Fritzsche U; Kissel T
Biodegradable microspheres containing influenza A vaccine: immune response in mice.
Vaccine 1999;17(9-10):1065-73.
1998: Zange R; Li Y; Kissel T
Biocompatibility testing of ABA triblock copolymers consisting of poly(L-lactic-co-glycolic acid) A blocks attached to a central poly(ethylene oxide) B block under in vitro conditions using different L929 mouse fibroblasts cell culture models.
Journal of controlled release : official journal of the Controlled Release Society 1998;56(1-3):249-58.
1998: Kriwet B; Walter E; Kissel T
Synthesis of bioadhesive poly(acrylic acid) nano- and microparticles using an inverse emulsion polymerization method for the entrapment of hydrophilic drug candidates.
Journal of controlled release : official journal of the Controlled Release Society 1998;56(1-3):149-58.
1998: Morlock M; Kissel T; Li Y X; Koll H; Winter G
Erythropoietin loaded microspheres prepared from biodegradable LPLG-PEO-LPLG triblock copolymers: protein stabilization and in-vitro release properties.
Journal of controlled release : official journal of the Controlled Release Society 1998;56(1-3):105-15.
1998: Bastian P; Bartkowski R; Köhler H; Kissel T
Chemo-embolization of experimental liver metastases. Part I: distribution of biodegradable microspheres of different sizes in an animal model for the locoregional therapy.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 1998;46(3):243-54.
1998: Altenburger R; Kissel T
Biotransformation of estradiol in the human keratinocyte cell line HaCaT: metabolism kinetics and the inhibitory effect of ethanol.
Pharmaceutical research 1998;15(11):1684-9.
1998: Altenburger R; Rohr U D; Kissel T
Rate control in transdermal beta-estradiol reservoir membrane systems: the role of membrane and adhesive layer.
Pharmaceutical research 1998;15(8):1238-43.
1998: Bittner B; Ronneberger B; Zange R; Volland C; Anderson J M; Kissel T
Bovine serum albumin loaded poly(lactide-co-glycolide) microspheres: the influence of polymer purity on particle characteristics.
Journal of microencapsulation 1998;15(4):495-514.
1998: Rohr U D; Altenburger R; Kissel T
Pharmacokinetics of the transdermal reservoir membrane system delivering beta-estradiol: in vitro/in vivo-correlation.
Pharmaceutical research 1998;15(6):877-82.
1998: Bittner B; Morlock M; Koll H; Winter G; Kissel T
Recombinant human erythropoietin (rhEPO) loaded poly(lactide-co-glycolide) microspheres: influence of the encapsulation technique and polymer purity on microsphere characteristics.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 1998;45(3):295-305.
1998: Mäder K; Bittner B; Li Y; Wohlauf W; Kissel T
Monitoring microviscosity and microacidity of the albumin microenvironment inside degrading microparticles from poly(lactide-co-glycolide) (PLG) or ABA-triblock polymers containing hydrophobic poly(lactide-co-glycolide) A blocks and hydrophilic poly(ethyleneoxide) B blocks.
Pharmaceutical research 1998;15(5):787-93.
1998: Kissel T; Werner U
Nasal delivery of peptides: an in vitro cell culture model for the investigation of transport and metabolism in human nasal epithelium.
Journal of controlled release : official journal of the Controlled Release Society 1998;53(1-3):195-203.
1997: Schartel B; Volland C; Li Y X; Wendorff J W; Kissel T
Dielectric and thermodynamic properties of biodegradable poly(D,L-lactide-co-glycolide) and the effect on the micro-encapsulation and release of captopril.
Journal of microencapsulation 1997;14(4):475-88.
1997: Kissel T; Koneberg R; Hilbert A K; Hungerer K D
Microencapsulation of antigens using biodegradable polyesters: facts and phantasies.
Behring Institute Mitteilungen 1997;(98):172-83.
1997: Werner U; Kissel T; Stüber W
Effects of peptide structure on transport properties of seven thyrotropin releasing hormone (TRH) analogues in a human intestinal cell line (Caco-2).
Pharmaceutical research 1997;14(2):246-50.
1996: Werner U; Kissel T; Reers M
Effects of permeation enhancers on the transport of a peptidomimetic thrombin inhibitor (CRC 220) in a human intestinal cell line (Caco-2).
Pharmaceutical research 1996;13(8):1219-27.
1996: Werner U; Kissel T
In-vitro cell culture models of the nasal epithelium: a comparative histochemical investigation of their suitability for drug transport studies.
Pharmaceutical research 1996;13(7):978-88.
1996: Ronneberger B; Kao W J; Anderson J M; Kissel T
In vivo biocompatibility study of ABA triblock copolymers consisting of poly(L-lactic-co-glycolic acid) A blocks attached to central poly(oxyethylene) B blocks.
Journal of biomedical materials research 1996;30(1):31-40.
1995: Walter E; Kissel T; Raddatz P
Transport of peptidomimetic renin inhibitors across monolayers of a human intestinal cell line (Caco-2): evidence for self-enhancement of paracellular transport route.
Pharmaceutical research 1995;12(11):1801-5.
1995: Werner U; Kissel T
Development of a human nasal epithelial cell culture model and its suitability for transport and metabolism studies under in vitro conditions.
Pharmaceutical research 1995;12(4):565-71.
1995: Walter E; Kissel T; Reers M; Dickneite G; Hoffmann D; Stüber W
Transepithelial transport properties of peptidomimetic thrombin inhibitors in monolayers of a human intestinal cell line (Caco-2) and their correlation to in vivo data.
Pharmaceutical research 1995;12(3):360-5.
1994: Walter E; Kissel T
Transepithelial transport and metabolism of thyrotropin-releasing hormone (TRH) in monolayers of a human intestinal cell line (Caco-2): evidence for an active transport component?
Pharmaceutical research 1994;11(11):1575-80.

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