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Hiroshi Kitagawa

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Kohei Kusada; Syo Matsumura; Katsutoshi Nagaoka; Katsutoshi Sato; Naoya Sumi; Tomokazu Yamamoto; Hirokazu Kobayashi; Yoshiki Kubota; Hiroshi Kitagawa
Discovery of face-centered-cubic ruthenium nanoparticles: facile size-controlled synthesis using the chemical reduction method.
Satomi Nadanaka; Naoko Shoji; Kazuyuki Sugahara; Kazushi Sugihara; Shaobo Zhou; Masahide Asano; Shoji Kagiyama; Hiroshi Kitagawa
EXTL2, a member of the EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner.
Hisashi Ōkawa; Masaaki Sadakiyo; Teppei Yamada; Mitsuhiko Maesato; Masaaki Ohba; Hiroshi Kitagawa
Proton-conductive magnetic metal-organic frameworks, {NR3(CH2COOH)}[M(a)(II)M(b)(III)(ox)3]: effect of carboxyl residue upon proton conduction.

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2013: Kohei Kusada; Syo Matsumura; Katsutoshi Nagaoka; Katsutoshi Sato; Naoya Sumi; Tomokazu Yamamoto; Hirokazu Kobayashi; Yoshiki Kubota; Hiroshi Kitagawa
Discovery of face-centered-cubic ruthenium nanoparticles: facile size-controlled synthesis using the chemical reduction method.
Journal of the American Chemical Society 2013;135(15):5493-6.
2013: Satomi Nadanaka; Naoko Shoji; Kazuyuki Sugahara; Kazushi Sugihara; Shaobo Zhou; Masahide Asano; Shoji Kagiyama; Hiroshi Kitagawa
EXTL2, a member of the EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner.
The Journal of biological chemistry 2013;288(13):9321-33.
2013: Hisashi Ōkawa; Masaaki Sadakiyo; Teppei Yamada; Mitsuhiko Maesato; Masaaki Ohba; Hiroshi Kitagawa
Proton-conductive magnetic metal-organic frameworks, {NR3(CH2COOH)}[M(a)(II)M(b)(III)(ox)3]: effect of carboxyl residue upon proton conduction.
Journal of the American Chemical Society 2013;135(6):2256-62.
2013: Shuhei Yamasaki; Hirokazu Kobayashi; Teppei Yamada; Hiroshi Kitagawa
Preparation of sub-10 nm AgI nanoparticles and a study on their phase transition temperature.
Chemistry, an Asian journal 2013;8(1):73-5.
2012: Tadahisa Mikami; Yumi Yabuta; Shinji Koyama; Hiroshi Kitagawa
Chondroitin sulfate is a crucial determinant for skeletal muscle development/regeneration and improvement of muscular dystrophies.
The Journal of biological chemistry 2012;287(46):38531-42.
2012: Toshiyasu Koike; Jun-Ichi Tamura; Tomomi Izumikawa; Hiroshi Kitagawa
Chondroitin sulfate-E fine-tunes osteoblast differentiation via ERK1/2, Smad3 and Smad1/5/8 signaling by binding to N-cadherin and cadherin-11.
Biochemical and biophysical research communications 2012;420(3):523-9.
2011: Satomi Nadanaka; Hiroshi Kitagawa
[Regulation of Wnt-3a signaling and diffusion by sulfated glycosaminoglycans].
Seikagaku. The Journal of Japanese Biochemical Society 2011;83(11):1027-31.
2011: Yoshimitsu Masuda; Fuqin Mu; Hiroshi Ono; Naruhiko Sawa; Haruo Ito; Hiroshi Kitagawa; Takeshi Zendo; Kenji Sonomoto
Identification and characterization of leucocyclicin Q, a novel cyclic bacteriocin produced by Leuconostoc mesenteroides TK41401.
Applied and environmental microbiology 2011;77(22):8164-70.
2011: Minoru Mitsumi; Takami Yamashita; Yuko Aiga; Koshiro Toriumi; Hiroshi Kitagawa; Tadaoki Mitani; Mohamedally Kurmoo
On the nature of the multiple ground states of the MMX mixed-valence chain compound, [Pt(II/III)2(n-PenCS2)4I]∞.
Inorganic chemistry 2011;50(10):4368-77.
2011: Tadahisa Mikami; Hiroshi Kitagawa
[Functional sugar codes in neural chondroitin sulfate chains].
Seikagaku. The Journal of Japanese Biochemical Society 2011;83(3):231-9.
2011: Tomomi Izumikawa; Yuka Okuura; Toshiyasu Koike; Naoki Sakoda; Hiroshi Kitagawa
Chondroitin 4-O-sulfotransferase-1 regulates the chain length of chondroitin sulfate in co-operation with chondroitin N-acetylgalactosaminyltransferase-2.
The Biochemical journal 2011;434(2):321-31.
2011: Satomi Nadanaka; Hiroki Kinouchi; Kayo Taniguchi-Morita; Jun-ichi Tamura; Hiroshi Kitagawa
Down-regulation of chondroitin 4-O-sulfotransferase-1 by Wnt signaling triggers diffusion of Wnt-3a.
The Journal of biological chemistry 2011;286(6):4199-208.
2010: Katsufumi Dejima; Daisuke Murata; Souhei Mizuguchi; Kazuko H Nomura; Tomomi Izumikawa; Hiroshi Kitagawa; Keiko Gengyo-Ando; Sawako Yoshina; Tomomi Ichimiya; Shoko Nishihara; Shohei Mitani; Kazuya Nomura
Two Golgi-resident 3'-Phosphoadenosine 5'-phosphosulfate transporters play distinct roles in heparan sulfate modifications and embryonic and larval development in Caenorhabditis elegans.
The Journal of biological chemistry 2010;285(32):24717-28.
2010: Lifen Yang; Shozo Kinoshita; Teppei Yamada; Seiichi Kanda; Hiroshi Kitagawa; Makoto Tokunaga; Takayoshi Ishimoto; Teppei Ogura; Ryo Nagumo; Akira Miyamoto; Michihisa Koyama
A metal-organic framework as an electrocatalyst for ethanol oxidation.
Angewandte Chemie (International ed. in English) 2010;49(31):5348-51.
2010: Megumi Okada; Satomi Nadanaka; Naoko Shoji; Jun-Ichi Tamura; Hiroshi Kitagawa
Biosynthesis of heparan sulfate in EXT1-deficient cells.
The Biochemical journal 2010;428(3):463-71.
2010: Tomomi Izumikawa; Nao Kanagawa; Yukiko Watamoto; Megumi Okada; Mika Saeki; Masahiro Sakano; Kazuyuki Sugahara; Kazushi Sugihara; Masahide Asano; Hiroshi Kitagawa
Impairment of embryonic cell division and glycosaminoglycan biosynthesis in glucuronyltransferase-I-deficient mice.
The Journal of biological chemistry 2010;285(16):12190-6.
2009: Kazuya Otsubo; Atsushi Kobayashi; Masato Hedo; Yoshiya Uwatoko; Hiroshi Kitagawa
Pressure-induced consecutive phase transitions of a metallic MMX-chain complex, Pt2(dtp)4I (dtp: C2H5CS2-).
Chemistry, an Asian journal 2009;4(11):1673-6.
2009: Miho Yamauchi; Hirokazu Kobayashi; Hiroshi Kitagawa
Hydrogen storage mediated by Pd and Pt nanoparticles.
Chemphyschem : a European journal of chemical physics and physical chemistry 2009;10(15):2566-76.
2009: Hisashi Okawa; Akihito Shigematsu; Masaaki Sadakiyo; Takuya Miyagawa; Ko Yoneda; Masaaki Ohba; Hiroshi Kitagawa
Oxalate-bridged bimetallic complexes {NH(prol)3}[MCr(ox)3] (M = Mn(II), Fe(II), Co(II); NH(prol)3(+) = tri(3-hydroxypropyl)ammonium) exhibiting coexistent ferromagnetism and proton conduction.
Journal of the American Chemical Society 2009;131(37):13516-22.
2009: Hirokazu Kobayashi; Miho Yamauchi; Ryuichi Ikeda; Hiroshi Kitagawa
Atomic-level Pd-Au alloying and controllable hydrogen-absorption properties in size-controlled nanoparticles synthesized by hydrogen reduction.
Chemical communications (Cambridge, England) 2009;(32):4806-8.
2009: Atsushi Kobayashi; Shinji Kitao; Makoto Seto; Ryuichi Ikeda; Hiroshi Kitagawa
(129)I Mössbauer spectroscopic study of a metallic MMX chain system.
Inorganic chemistry 2009;48(16):8044-9.
2009: Toshiyasu Koike; Tomomi Izumikawa; Jun-Ichi Tamura; Hiroshi Kitagawa
FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan-protein linkage region.
The Biochemical journal 2009;421(2):157-62.
2009: Teppei Yamada; Hiroshi Kitagawa
Protection and deprotection approach for the introduction of functional groups into metal-organic frameworks.
Journal of the American Chemical Society 2009;131(18):6312-3.
2009: Shuji Mizumoto; Tadahisa Mikami; Daiki Yasunaga; Naoki Kobayashi; Hajime Yamauchi; Ayumi Miyake; Nobuyuki Itoh; Hiroshi Kitagawa; Kazuyuki Sugahara
Chondroitin 4-O-sulfotransferase-1 is required for somitic muscle development and motor axon guidance in zebrafish.
The Biochemical journal 2009;419(2):387-99.
2009: Teppei Yamada; Masaaki Sadakiyo; Hiroshi Kitagawa
High proton conductivity of one-dimensional ferrous oxalate dihydrate.
Journal of the American Chemical Society 2009;131(9):3144-5.
2009: Tadahisa Mikami; Daiki Yasunaga; Hiroshi Kitagawa
Contactin-1 is a functional receptor for neuroregulatory chondroitin sulfate-E.
The Journal of biological chemistry 2009;284(7):4494-9.
2008: Katsuhiko Kanaizuka; Rie Haruki; Osami Sakata; Mamoru Yoshimoto; Yasuyuki Akita; Hiroshi Kitagawa
Construction of highly oriented crystalline surface coordination polymers composed of copper dithiooxamide complexes.
Journal of the American Chemical Society 2008;130(47):15778-9.
2008: Hiroshi Kitagawa; K Tsutsumi; Akemi Ikegami-Kuzuhara; Satomi Nadanaka; F Goto; Tomoya Ogawa; Kazuyuki Sugahara
Sulfation of the galactose residues in the glycosaminoglycan-protein linkage region by recombinant human chondroitin 6-O-sulfotransferase-1.
The Journal of biological chemistry 2008;283(41):27438-43.
2008: Satomi Nadanaka; Miho Ishida; Masami Ikegami; Hiroshi Kitagawa
Chondroitin 4-O-sulfotransferase-1 modulates Wnt-3a signaling through control of E disaccharide expression of chondroitin sulfate.
The Journal of biological chemistry 2008;283(40):27333-43.
2008: Shinji Miyata; Satomi Nadanaka; Hiroshi Kitagawa
[Roles of sulfated glycosaminoglycans in receptor binding].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2008;53(12 Suppl):1533-9.
2008: Satomi Nadanaka; Hiroshi Kitagawa
Heparan sulphate biosynthesis and disease.
Journal of biochemistry 2008;144(1):7-14.
2008: Y Tone; Lars C Pedersen; Tomoko Yamamoto; Tomomi Izumikawa; Hiroshi Kitagawa; Junko Nishihara; Jun-ichi Tamura; Masahiko Negishi; Kazuyuki Sugahara
2-o-phosphorylation of xylose and 6-o-sulfation of galactose in the protein linkage region of glycosaminoglycans influence the glucuronyltransferase-I activity involved in the linkage region synthesis.
The Journal of biological chemistry 2008;283(24):16801-7.
2008: Tomomi Izumikawa; Toshiyasu Koike; Shoko Shiozawa; Kazuyuki Sugahara; Jun-ichi Tamura; Hiroshi Kitagawa
Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members.
The Journal of biological chemistry 2008;283(17):11396-406.
2008: Hirokazu Kobayashi; Miho Yamauchi; Hiroshi Kitagawa; Yoshiki Kubota; Kenichi Kato; Masaki Takata
On the nature of strong hydrogen atom trapping inside Pd nanoparticles.
Journal of the American Chemical Society 2008;130(6):1828-9.
2008: Hirokazu Kobayashi; Miho Yamauchi; Hiroshi Kitagawa; Yoshiki Kubota; Kenichi Kato; Masaki Takata
Hydrogen absorption in the core/shell interface of Pd/Pt nanoparticles.
Journal of the American Chemical Society 2008;130(6):1818-9.
2007: Anurag Purushothaman; Junko Fukuda; Shuji Mizumoto; Gerdy B ten Dam; Toin H van Kuppevelt; Hiroshi Kitagawa; Tadahisa Mikami; Kazuyuki Sugahara
Functions of chondroitin sulfate/dermatan sulfate chains in brain development. Critical roles of E and iE disaccharide units recognized by a single chain antibody GD3G7.
The Journal of biological chemistry 2007;282(27):19442-52.
2007: Tomomi Izumikawa; Toru Uyama; Yuka Okuura; Kazuyuki Sugahara; Hiroshi Kitagawa
Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor.
The Biochemical journal 2007;403(3):545-52.
2007: Hiroshi Kitagawa; Tomomi Izumikawa; Souhei Mizuguchi; Katsufumi Dejima; Kazuko H Nomura; Noriyuki Egusa; Fumiyasu Taniguchi; Jun-ichi Tamura; Keiko Gengyo-Ando; Shohei Mitani; Kazuya Nomura; Kazuyuki Sugahara
Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis.
The Journal of biological chemistry 2007;282(11):8533-44.
2007: Sota Shibahara; Hiroshi Kitagawa; Yoshiki Ozawa; Koshiro Toriumi; Takashi Kubo; Kazuhiro Nakasuji
Syntheses and unusual segregated-alternated hybrid stacking structure of hydrogen-bonded charge-transfer complexes composed of bis[2,3-pyridinedithiolate]metal complexes.
Inorganic chemistry 2007;46(4):1162-70.
2006: Toru Uyama; Miho Ishida; Tomomi Izumikawa; Edward Trybala; Frank Tufaro; Tomas Bergström; Kazuyuki Sugahara; Hiroshi Kitagawa
Chondroitin 4-O-sulfotransferase-1 regulates E disaccharide expression of chondroitin sulfate required for herpes simplex virus infectivity.
The Journal of biological chemistry 2006;281(50):38668-74.
2006: Chihiro Yamamoto; Hiroyuki Nishikawa; Masayuki Nihei; Takuya Shiga; Masato Hedo; Yoshiya Uwatoko; Hiroshi Sawa; Hiroshi Kitagawa; Yasujiro Taguchi; Yoshihiro Iwasa; Hiroki Oshio
Electrical conducting bis(oxalato)platinate complex with direct connection of CuII ions.
Inorganic chemistry 2006;45(25):10270-6.
2006: Atsushi Kobayashi; Hiroshi Kitagawa
Mixed-valence two-legged MX-ladder complex with a pair of out-of-phase charge-density waves.
Journal of the American Chemical Society 2006;128(37):12066-7.
2006: Kazuya Otsubo; Atsushi Kobayashi; Hiroshi Kitagawa; Masato Hedo; Yoshiya Uwatoko; Hajime Sagayama; Yusuke Wakabayashi; Hiroshi Sawa
Most stable metallic phase of the mixed-valence MMX-chain, Pt2(dtp)4I (dtp = C2H5CS2-), in purely d-electronic conductors based on the transition-metal complex.
Journal of the American Chemical Society 2006;128(25):8140-1.
2006: Katsufumi Dejima; Akira Seko; Katsuko Yamashita; Keiko Gengyo-Ando; Shohei Mitani; Tomomi Izumikawa; Hiroshi Kitagawa; Kazuyuki Sugahara; Souhei Mizuguchi; Kazuya Nomura
Essential roles of 3'-phosphoadenosine 5'-phosphosulfate synthase in embryonic and larval development of the nematode Caenorhabditis elegans.
The Journal of biological chemistry 2006;281(16):11431-40.
2006: Makoto Tadokoro; Syoko Fukui; Tadanori Kitajima; Yuki Nagao; Shin'ichi Ishimaru; Hiroshi Kitagawa; Kiyoshi Isobe; Kazuhiro Nakasuji
Structures and phase transition of multi-layered water nanotube confined to nanochannels.
Chemical communications (Cambridge, England) 2006;(12):1274-6.
2006: Tomomi Izumikawa; Noriyuki Egusa; Fumiyasu Taniguchi; Kazuyuki Sugahara; Hiroshi Kitagawa
Heparan sulfate polymerization in Drosophila.
The Journal of biological chemistry 2006;281(4):1929-34.
2006: Atsushi Kobayashi; Takahiko Kojima; Ryuichi Ikeda; Hiroshi Kitagawa
Synthesis of a one-dimensional metal-dimer assembled system with interdimer interaction, M2(dtp)4 (M = Ni, Pd; dtp = dithiopropionato).
Inorganic chemistry 2006;45(1):322-7.
2005: Kicki Bergefall; Edward Trybala; Maria Johansson; Toru Uyama; Satomi Naito; Shuhei Yamada; Hiroshi Kitagawa; Kazuyuki Sugahara; Tomas Bergström
Chondroitin sulfate characterized by the E-disaccharide unit is a potent inhibitor of herpes simplex virus infectivity and provides the virus binding sites on gro2C cells.
The Journal of biological chemistry 2005;280(37):32193-9.
2004: Tomomi Izumikawa; Hiroshi Kitagawa; Souhei Mizuguchi; Kazuko H Nomura; Kazuya Nomura; Jun-ichi Tamura; Keiko Gengyo-Ando; Shohei Mitani; Kazuyuki Sugahara
Nematode chondroitin polymerizing factor showing cell-/organ-specific expression is indispensable for chondroitin synthesis and embryonic cell division.
The Journal of biological chemistry 2004;279(51):53755-61.
2004: Hiroshi Kitagawa
[Biosynthesis of the sulfated glycosaminoglycans in relation to human diseases].
Seikagaku. The Journal of Japanese Biochemical Society 2004;76(9):1175-90.
2004: Souhei Mizuguchi; Kazuko H Nomura; Katsufumi Dejima; Kazuya Nomura; Kazuyuki Sugahara; Hiroshi Kitagawa; Toru Uyama; Shohei Mitani; Keiko Gengyo-Ando
[Chondroitin sugars in embryonic cell division of the nematode C. elegans].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2004;49(2):141-7.
2003: Byung-Taek Kim; Hiroshi Kitagawa; Junko Tanaka; Jun-ichi Tamura; Kazuyuki Sugahara
In vitro heparan sulfate polymerization: crucial roles of core protein moieties of primer substrates in addition to the EXT1-EXT2 interaction.
The Journal of biological chemistry 2003;278(43):41618-23.
2003: Kazuyuki Sugahara; Tadahisa Mikami; Toru Uyama; Souhei Mizuguchi; Kazuya Nomura; Hiroshi Kitagawa
Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate.
Current opinion in structural biology 2003;13(5):612-20.
2003: Tadahisa Mikami; Shuji Mizumoto; Naohide Kago; Hiroshi Kitagawa; Kazuyuki Sugahara
Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis.
The Journal of biological chemistry 2003;278(38):36115-27.
2003: Hiroshi Kitagawa; Tomomi Izumikawa; Toru Uyama; Kazuyuki Sugahara
Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization.
The Journal of biological chemistry 2003;278(26):23666-71.
2003: Souhei Mizuguchi; Toru Uyama; Hiroshi Kitagawa; Kazuko H Nomura; Katsufumi Dejima; Keiko Gengyo-Ando; Shohei Mitani; Kazuyuki Sugahara; Kazuya Nomura
Chondroitin proteoglycans are involved in cell division of Caenorhabditis elegans.
Nature 2003;423(6938):443-8.
2003: Byung-Taek Kim; Kazunori Tsuchida; John Lincecum; Hiroshi Kitagawa; Merton Bernfield; Kazuyuki Sugahara
Identification and characterization of three Drosophila melanogaster glucuronyltransferases responsible for the synthesis of the conserved glycosaminoglycan-protein linkage region of proteoglycans. Two novel homologs exhibit broad specificity toward oligosaccharides from proteoglycans, glycoproteins, and glycosphingolipids.
The Journal of biological chemistry 2003;278(11):9116-24.
2003: Toru Uyama; Hiroshi Kitagawa; Junko Tanaka; Jun-ichi Tamura; Tomoya Ogawa; Kazuyuki Sugahara
Molecular cloning and expression of a second chondroitin N-acetylgalactosaminyltransferase involved in the initiation and elongation of chondroitin/dermatan sulfate.
The Journal of biological chemistry 2003;278(5):3072-8.
2002: Kazuyuki Sugahara; Hiroshi Kitagawa
Heparin and heparan sulfate biosynthesis.
IUBMB life 2002;54(4):163-75.
2002: Minoru Mitsumi; Kouhei Kitamura; Ayumi Morinaga; Yoshiki Ozawa; Mototada Kobayashi; Koshiro Toriumi; Yasuhito Iso; Hiroshi Kitagawa; Tadaoki Mitani
Valence-ordering structures and magnetic behavior of metallic MMX chain compounds.
Angewandte Chemie (International ed. in English) 2002;41(15):2767-71.
2002: Hiroshi Kitagawa
[Biosynthetic mechanism of the bioactive sulfated glycosaminoglycans].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2002;122(7):435-50.
2002: Byung-Taek Kim; Hiroshi Kitagawa; Jun-ichi Tamura Ji; Marion Kusche-Gullberg; Ulf Lindahl; Kazuyuki Sugahara
Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: chain initiation and elongation.
The Journal of biological chemistry 2002;277(16):13659-65.
2002: Toru Uyama; Hiroshi Kitagawa; Jun-ichi Tamura Ji; Kazuyuki Sugahara
Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate.
The Journal of biological chemistry 2002;277(11):8841-6.
2001: Minoru Mitsumi; T Murase; H Kishida; T Yoshinari; Yoshiki Ozawa; Koshiro Toriumi; T Sonoyama; Hiroshi Kitagawa; T Mitani
Metallic behavior and periodical valence ordering in a MMX chain compound, Pt(2)(EtCS(2))(4)I.
Journal of the American Chemical Society 2001;123(45):11179-92.
2001: Hiroshi Kitagawa; Toru Uyama; Kazuyuki Sugahara
Molecular cloning and expression of a human chondroitin synthase.
The Journal of biological chemistry 2001;276(42):38721-6.
2001: Hiroshi Kitagawa; M Taoka; Y Tone; Kazuyuki Sugahara
Human glycosaminoglycan glucuronyltransferase I gene and a related processed pseudogene: genomic structure, chromosomal mapping and characterization.
The Biochemical journal 2001;358(Pt 3):539-46.
2001: Byung-Taek Kim; Hiroshi Kitagawa; Jun-ichi Tamura; T Saito; Marion Kusche-Gullberg; Ulf Lindahl; Kazuyuki Sugahara
Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7176-81.
2001: Kazuyuki Sugahara; Shuhei Yamada; Hiroshi Kitagawa
[Biosynthetic mechanism of sulfated glycosaminoglycans].
Seikagaku. The Journal of Japanese Biochemical Society 2001;73(6):458-70.
2001: Hiroshi Kitagawa; Noriyuki Egusa; Jun-ichi Tamura; Marion Kusche-Gullberg; Ulf Lindahl; Kazuyuki Sugahara
rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate.
The Journal of biological chemistry 2001;276(7):4834-8.
2000: H Sakaguchi; Hiroshi Kitagawa; Kazuyuki Sugahara
Functional expression and genomic structure of human N-acetylglucosamine-6-O-sulfotransferase that transfers sulfate to beta-N-acetylglucosamine at the nonreducing end of an N-acetyllactosamine sequence.
Biochimica et biophysica acta 2000;1523(2-3):269-76.
2000: C Senay; T Lind; K Muguruma; Y Tone; Hiroshi Kitagawa; Kazuyuki Sugahara; Kerstin Lidholt; Ulf Lindahl; Marion Kusche-Gullberg
The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis.
EMBO reports 2000;1(3):282-6.
2000: Hiroshi Kitagawa; Masaki Fujita; N Ito; Kazuyuki Sugahara
Molecular cloning and expression of a novel chondroitin 6-O-sulfotransferase.
The Journal of biological chemistry 2000;275(28):21075-80.
2000: Y Tone; Hiroshi Kitagawa; Kazuyuki Sugahara
[Glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans].
Seikagaku. The Journal of Japanese Biochemical Society 2000;72(5):373-6.
2000: Hiroshi Kitagawa; Kazuyuki Sugahara
[Biosynthesis of heparan sulfate and the tumor suppressor EXT gene family].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(4):579-86.
1999: Y Tone; Hiroshi Kitagawa; K Imiya; S Oka; T Kawasaki; Kazuyuki Sugahara
Characterization of recombinant human glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans.
FEBS letters 1999;459(3):415-20.
1999: Shuhei Yamada; Irma Van Die; DH van den Eijnden; A Yokota; Hiroshi Kitagawa; Kazuyuki Sugahara
Demonstration of glycosaminoglycans in Caenorhabditis elegans.
FEBS letters 1999;459(3):327-31.
1999: Kazunori Tsuchida; T Lind; Hiroshi Kitagawa; Ulf Lindahl; Kazuyuki Sugahara; Kerstin Lidholt
Purification and characterization of fetal bovine serum beta-N-acetyl-D-galactosaminyltransferase and beta-D-glucuronyltransferase involved in chondroitin sulfate biosynthesis.
European journal of biochemistry / FEBS 1999;264(2):461-7.
1999: Hiroshi Kitagawa; Y Kano; H Shimakawa; F Goto; Tomoya Ogawa; H Okabe; Kazuyuki Sugahara
Identification and characterization of a novel UDP-GalNAc:GlcAbeta-R alpha1,4-N-acetylgalactosaminyltransferase from a human sarcoma cell line.
Glycobiology 1999;9(7):697-703.
1999: S Nadanaka; Hiroshi Kitagawa; F Goto; Jun-ichi Tamura; KW Neumann; Tomoya Ogawa; Kazuyuki Sugahara
Involvement of the core protein in the first beta-N-acetylgalactosamine transfer to the glycosaminoglycan-protein linkage-region tetrasaccharide and in the subsequent polymerization: the critical determining step for chondroitin sulphate biosynthesis.
The Biochemical journal 1999;340 ( Pt 2)():353-7.
1999: Hiroshi Kitagawa; H Shimakawa; Kazuyuki Sugahara
The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate.
The Journal of biological chemistry 1999;274(20):13933-7.
1998: K Tsutsumi; H Shimakawa; Hiroshi Kitagawa; Kazuyuki Sugahara
Functional expression and genomic structure of human chondroitin 6-sulfotransferase.
FEBS letters 1998;441(2):235-41.
1998: S Nadanaka; Hiroshi Kitagawa; Kazuyuki Sugahara
Demonstration of the immature glycosaminoglycan tetrasaccharide sequence GlcAbeta1-3Galbeta1-3Galbeta1-4Xyl on recombinant soluble human alpha-thrombomodulin. An oligosaccharide structure on a "part-time" proteoglycan.
The Journal of biological chemistry 1998;273(50):33728-34.
1998: Kazunori Tsuchida; Hiroshi Kitagawa; Kazuyuki Sugahara
[Biosynthesis of sugar chain backbone in glycosaminoglycan].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1998;43(16 Suppl):2594-601.
1998: Hiroshi Kitagawa; Y Tone; Jun-ichi Tamura; KW Neumann; Tomoya Ogawa; S Oka; T Kawasaki; Kazuyuki Sugahara
Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans.
The Journal of biological chemistry 1998;273(12):6615-8.
1997: Hiroshi Kitagawa; K Tsutsumi; Y Tone; Kazuyuki Sugahara
Developmental regulation of the sulfation profile of chondroitin sulfate chains in the chicken embryo brain.
The Journal of biological chemistry 1997;272(50):31377-81.
1997: Hiroshi Kitagawa; M Oyama; K Masayama; Y Yamaguchi; Kazuyuki Sugahara
Structural variations in the glycosaminoglycan-protein linkage region of recombinant decorin expressed in Chinese hamster ovary cells.
Glycobiology 1997;7(8):1175-80.
1997: Hiroshi Kitagawa; M Ujikawa; K Tsutsumi; Jun-ichi Tamura; KW Neumann; Tomoya Ogawa; Kazuyuki Sugahara
Characterization of serum beta-glucuronyltransferase involved in chondroitin sulfate biosynthesis.
Glycobiology 1997;7(7):905-11.
1997: Kerstin Lidholt; M Fjelstad; Ulf Lindahl; F Goto; T Ogawa; Hiroshi Kitagawa; Kazuyuki Sugahara
Assessment of glycosaminoglycan-protein linkage tetrasaccharides as acceptors for GalNAc- and GlcNAc-transferases from mouse mastocytoma.
Glycoconjugate journal 1997;14(6):737-42.
1997: Hiroshi Kitagawa; K Tsutsumi; M Ujikawa; F Goto; Jun-ichi Tamura; KW Neumann; Tomoya Ogawa; Kazuyuki Sugahara
Regulation of chondroitin sulfate biosynthesis by specific sulfation: acceptor specificity of serum beta-GalNAc transferase revealed by structurally defined oligosaccharides.
Glycobiology 1997;7(4):531-7.
1997: Hiroshi Kitagawa; Y Tanaka; Shuhei Yamada; N Seno; Stuart M Haslam; Howard R Morris; Anne Dell; Kazuyuki Sugahara
A novel pentasaccharide sequence GlcA(3-sulfate)(beta1-3)GalNAc(4-sulfate)(beta1-4)(Fuc alpha1-3)GlcA(beta1-3)GalNAc(4-sulfate) in the oligosaccharides isolated from king crab cartilage chondroitin sulfate K and its differential susceptibility to chondroitinases and hyaluronidase.
Biochemistry 1997;36(13):3998-4008.
1996: Kazuyuki Sugahara; Y Tanaka; Shuhei Yamada; N Seno; Hiroshi Kitagawa; Stuart M Haslam; Howard R Morris; Anne Dell
Novel sulfated oligosaccharides containing 3-O-sulfated glucuronic acid from king crab cartilage chondroitin sulfate K. Unexpected degradation by chondroitinase ABC.
The Journal of biological chemistry 1996;271(43):26745-54.
1996: Hiroshi Kitagawa; M Ujikawa; Kazuyuki Sugahara
Developmental changes in serum UDP-GlcA:chondroitin glucuronyltransferase activity.
The Journal of biological chemistry 1996;271(12):6583-5.
1995: Hiroshi Kitagawa; A Kinoshita; Kazuyuki Sugahara
Microanalysis of glycosaminoglycan-derived disaccharides labeled with the fluorophore 2-aminoacridone by capillary electrophoresis and high-performance liquid chromatography.
Analytical biochemistry 1995;232(1):114-21.
1995: Hiroshi Kitagawa; Y Tanaka; Kazunori Tsuchida; F Goto; Tomoya Ogawa; K Lidholt; U Lindahl; Kazuyuki Sugahara
N-acetylgalactosamine (GalNAc) transfer to the common carbohydrate-protein linkage region of sulfated glycosaminoglycans. Identification of UDP-GalNAc:chondro-oligosaccharide alpha-N-acetylgalactosaminyltransferase in fetal bovine serum.
The Journal of biological chemistry 1995;270(38):22190-5.
1995: Hiroshi Kitagawa; Kazunori Tsuchida; M Ujikawa; Kazuyuki Sugahara
Detection and characterization of UDP-GalNAc: chondroitin N-acetylgalactosaminyltransferase in bovine serum using a simple assay method.
Journal of biochemistry 1995;117(5):1083-7.