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Toshio Kitamura

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Toshio Kitamura
Guest editorial: Genetic and epigenetic alterations in hematopoietic malignancies.
Kumi Izawa; Ayako Kaitani; Toshio Kitamura; Takaya Abe; Masamichi Isobe; Shinichi Ito; Hiroshi Kiyonari; Akie Maehara; Toshihiro Matsukawa; Takayuki Matsuoka; Fumio Nakahara; Toshihiko Oki; Ko Okumura; Mariko Takahashi; Yoshinori Yamanishi; Jiro Kitaura
The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide.
Yuki Kagiyama; Kimihito C Kawabata; Hiroyuki Aburatani; Daichi Inoue; Kumi Izawa; Jiro Kitaura; Yukiko Komeno; Toshihiro Matsukawa; Fumio Nakahara; Toshihiko Oki; Katsuaki Sato; Katsuhiro Togami; Tomoyuki Uchida; Toshio Kitamura
Upregulation of CD200R1 in lineage-negative leukemic cells is characteristic of AML1-ETO-positive leukemia in mice.

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All Publications

2013: Toshio Kitamura
Guest editorial: Genetic and epigenetic alterations in hematopoietic malignancies.
International journal of hematology 2013;97(2):163-4.
2012: Kumi Izawa; Ayako Kaitani; Toshio Kitamura; Takaya Abe; Masamichi Isobe; Shinichi Ito; Hiroshi Kiyonari; Akie Maehara; Toshihiro Matsukawa; Takayuki Matsuoka; Fumio Nakahara; Toshihiko Oki; Ko Okumura; Mariko Takahashi; Yoshinori Yamanishi; Jiro Kitaura
The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide.
Immunity 2012;37(5):827-39.
2012: Yuki Kagiyama; Kimihito C Kawabata; Hiroyuki Aburatani; Daichi Inoue; Kumi Izawa; Jiro Kitaura; Yukiko Komeno; Toshihiro Matsukawa; Fumio Nakahara; Toshihiko Oki; Katsuaki Sato; Katsuhiro Togami; Tomoyuki Uchida; Toshio Kitamura
Upregulation of CD200R1 in lineage-negative leukemic cells is characteristic of AML1-ETO-positive leukemia in mice.
International journal of hematology 2012;96(5):638-48.
2012: Takuma Shibata; Naoki Takemura; Natsuko Tanimura; Satoshi Uematsu; Yuji Motoi; Sachiko Akashi-Takamura; Shizuo Akira; Yoshiyuki Goto; Kumi Izawa; Thangaraj Karuppuchamy; Toshio Kitamura; Jiro Kitaura; Hiroshi Kiyono; Jun Kunisawa; Xiaobing Li; Kensuke Miyake
PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells.
International immunology 2012;24(10):613-23.
2012: Yutaka Enomoto; Naoko Kato; Toshio Kitamura; Jiro Kitaura; Hideki Nakakuma; Koutarou Nishimura; Masaya Shimanuki; Mariko Takahashi; Takashi Sonoki
MicroRNA-125b-1 accelerates a C-terminal mutant of C/EBPα (C/EBPα-C(m))-induced myeloid leukemia.
International journal of hematology 2012;96(3):334-41.
2012: Toshio Kitamura; Daichi Inoue
HDACI-induced thrombocytopenia is caused by its unexpected target.
Experimental hematology 2012;40(9):695-7.
2012: Yoshinori Yamanishi; Yutaka Enomoto; Masamichi Isobe; Shinichi Ito; Kumi Izawa; Ayako Kaitani; Masunori Kajikawa; Toshio Kitamura; Hiroki Kurihara; Akie Maehara; Fumio Nakahara; Toshihiko Oki; Mariko Takahashi; Katsuhiro Togami; Akiho Tsuchiya; Tomoyuki Uchida; Jiro Kitaura
A soluble form of LMIR5/CD300b amplifies lipopolysaccharide-induced lethal inflammation in sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(4):1773-9.
2012: Noriko Doki; Toshio Kitamura
[Molecules of signal transduction].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 2():69-74.
2012: Noriko Doki; Hironori Harada; Yuka Harada; Daichi Inoue; Masamichi Isobe; Shinichi Ito; Kumi Izawa; Yuki Kagiyama; Naoko Kato; Jiro Kitaura; Akie Maehara; Fumio Nakahara; Toshihiko Oki; Katsuhiro Togami; Tomoyuki Uchida; Toshio Kitamura
Fyn is not essential for Bcr-Abl-induced leukemogenesis in mouse bone marrow transplantation models.
International journal of hematology 2012;95(2):167-75.
2012: Yuko Goto-Koshino; Toshio Kitamura; Kana Kuroda; Daichi Abe; Yumi Fukuchi; Shinichiro Okamoto; Fumi Shibata; Hideaki Nakajima
Robo4 plays a role in bone marrow homing and mobilization, but is not essential in the long-term repopulating capacity of hematopoietic stem cells.
PloS one 2012;7(11):e50849.
2012: Fumi Shibata-Minoshima; Jiro Kitaura; Fumio Nakahara; Toshihiko Oki; Noriko Doki; Junya Fukuoka; Shun-Ichiro Kageyama; Toshio Kitamura
Identification of RHOXF2 (PEPP2) as a cancer-promoting gene by expression cloning.
International journal of oncology 2012;40(1):93-8.
2011: Akihide Yoshimi; Susumu Goyama; Naoko Watanabe-Okochi; Yumiko Yoshiki; Yasuhito Nannya; Eriko Nitta; Shunya Arai; Tomohiko Sato; Munetake Shimabe; Masahiro Nakagawa; Yoichi Imai; Toshio Kitamura; Mineo Kurokawa
Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins.
Blood 2011;117(13):3617-28.
2011: Naoko Kato; Jiro Kitaura; Noriko Doki; Yukiko Komeno; Naoko Watanabe-Okochi; Katsuhiro Togami; Fumio Nakahara; Toshihiko Oki; Yutaka Enomoto; Yumi Fukuchi; Hideaki Nakajima; Yuka Harada; Hironori Harada; Toshio Kitamura
Two types of C/EBPα mutations play distinct but collaborative roles in leukemogenesis: lessons from clinical data and BMT models.
Blood 2011;117(1):221-33.
2011: Toshio Kitamura
[STAT3 inhibitor].
Gan to kagaku ryoho. Cancer & chemotherapy 2011;38(1):19-22.
2010: Yoshinori Yamanishi; Jiro Kitaura; Kumi Izawa; Ayako Kaitani; Yukiko Komeno; Masaki Nakamura; Satoshi Yamazaki; Yutaka Enomoto; Toshihiko Oki; Hisaya Akiba; Takaya Abe; Tadasuke Komori; Yoshihiro Morikawa; Hiroshi Kiyonari; Toshiyuki Takai; Ko Okumura; Toshio Kitamura
TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury.
The Journal of experimental medicine 2010;207(7):1501-11.
2010: Fumio Nakahara; Mamiko Sakata-Yanagimoto; Yukiko Komeno; Naoko Kato; Tomoyuki Uchida; Kyoko Haraguchi; Keiki Kumano; Yuka Harada; Hironori Harada; Jiro Kitaura; Seishi Ogawa; Mineo Kurokawa; Toshio Kitamura; Shigeru Chiba
Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia.
Blood 2010;115(14):2872-81.
2009: Ryoichi Ono; Hidetoshi Kumagai; Hideaki Nakajima; A Hishiya; Tomohiko Taki; K Horikawa; K Takatsu; T Satoh; Yasuhide Hayashi; Toshio Kitamura; Tetsuya Nosaka
Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation.
Leukemia 2009;23(12):2197-209.
2009: Toshihiko Oki; Koji Eto; Kumi Izawa; Yoshinori Yamanishi; Naoki Inagaki; Jon Frampton; Toshio Kitamura; Jiro Kitaura
Evidence that integrin alpha IIb beta 3-dependent interaction of mast cells with fibrinogen exacerbates chronic inflammation.
The Journal of biological chemistry 2009;284(45):31463-72.
2009: Naoko Kato; Toshio Kitamura
[Cytogenetic abnormalities and gene mutations in myeloid leukemia].
Nihon rinsho. Japanese journal of clinical medicine 2009;67(10):1875-9.
2009: Noriko Doki; Toshiyuki Kawashima; Yasushi Nomura; Akiho Tsuchiya; Chitose Oneyama; Tsuyoshi Akagi; Yoshihisa Nojima; Toshio Kitamura
Constitutive phosphorylation of a Rac GAP MgcRacGAP is implicated in v-Src-induced transformation of NIH3T3 cells.
Cancer science 2009;100(9):1675-9.
2009: Kumi Izawa; Jiro Kitaura; Yoshinori Yamanishi; Takayuki Matsuoka; Ayako Kaitani; Masahiro Sugiuchi; Mariko Takahashi; Akie Maehara; Yutaka Enomoto; Toshihiko Oki; Toshiyuki Takai; Toshio Kitamura
An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1: LMIR3 augments lipopolysaccharide response through association with FcRgamma in mast cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):925-36.
2009: Yukiko Komeno; Jiro Kitaura; Toshio Kitamura
Molecular bases of myelodysplastic syndromes: lessons from animal models.
Journal of cellular physiology 2009;219(3):529-34.
2009: Naoko Watanabe-Okochi; Toshihiko Oki; Yukiko Komeno; Naoko Kato; Koichiro Yuji; Ryoichi Ono; Yuka Harada; Hironori Harada; Yasuhide Hayashi; Hideaki Nakajima; Tetsuya Nosaka; Jiro Kitaura; Toshio Kitamura
Possible involvement of RasGRP4 in leukemogenesis.
International journal of hematology 2009;89(4):470-81.
2009: Toshiyuki Kawashima; Ying Chun Bao; Yukinori Minoshima; Yasushi Nomura; Tomonori Hatori; Tetsuya Hori; Tatsuo Fukagawa; Toshiyuki Fukada; Noriko Takahashi; Tetsuya Nosaka; Makoto Inoue; Tomohiro Sato; Mutsuko Kukimoto-Niino; Mikako Shirouzu; Shigeyuki Yokoyama; Toshio Kitamura
A Rac GTPase-activating protein, MgcRacGAP, is a nuclear localizing signal-containing nuclear chaperone in the activation of STAT transcription factors.
Molecular and cellular biology 2009;29(7):1796-813.
2009: Hideaki Nakajima; Toshiki Tamura; Miyuki Ito; Fumi Shibata; Kana Kuroda; Yumi Fukuchi; Naohide Watanabe; Toshio Kitamura; Yasuo Ikeda; Makoto Handa
SHD1 is a novel cytokine-inducible, negative feedback regulator of STAT5-dependent transcription.
Blood 2009;113(5):1027-36.
2009: Fumi Shibata; Yuko Goto-Koshino; Yoshihiro Morikawa; Tadasuke Komori; Miyuki Ito; Yumi Fukuchi; Jeffrey P Houchins; Monica Tsang; Dean Y Li; Toshio Kitamura; Hideaki Nakajima
Roundabout 4 is expressed on hematopoietic stem cells and potentially involved in the niche-mediated regulation of the side population phenotype.
Stem cells (Dayton, Ohio) 2009;27(1):183-90.
2008: Rieko Sekine; Toshio Kitamura; Takashi Tsuji; Arinobu Tojo
Efficient retroviral transduction of human B-lymphoid and myeloid progenitors: marked inhibition of their growth by the Pax5 transgene.
International journal of hematology 2008;87(4):351-62.
2008: Naoko Watanabe-Okochi; Jiro Kitaura; Ryoichi Ono; Hironori Harada; Yuka Harada; Yukiko Komeno; Hideaki Nakajima; Tetsuya Nosaka; Toshiya Inaba; Toshio Kitamura
AML1 mutations induced MDS and MDS/AML in a mouse BMT model.
Blood 2008;111(8):4297-308.
2008: Yoshinori Yamanishi; Jiro Kitaura; Kiyoko Izawa; Takayuki Matsuoka; Toshihiko Oki; Yang Lu; Fumi Shibata; Satoshi Yamazaki; Hidetoshi Kumagai; Hideaki Nakajima; Mari Maeda-Yamamoto; Victor L J Tybulewicz; Toshiyuki Takai; Toshio Kitamura
Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells.
Blood 2008;111(2):688-98.
2008: Toshiyuki Kawashima; Toshio Kitamura
Rac and nuclear translocation of signal transducers and activators of transcription factors.
Methods in enzymology 2008;439():171-80.
2007: Y Lu; Jiro Kitaura; Toshikazu Oki; Yukiko Komeno; Katsutoshi Ozaki; Mari Kiyono; Hidetoshi Kumagai; Hideaki Nakajima; Tetsuya Nosaka; Hiroyuki Aburatani; Toshio Kitamura
Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD.
Leukemia 2007;21(11):2246-57.
2007: Rieko Sekine; Toshio Kitamura; Takashi Tsuji; Arinobu Tojo
Identification and comparative analysis of Pax5 C-terminal isoforms expressed in human cord blood-derived B cell progenitors.
Immunology letters 2007;111(1):21-5.
2007: Kumi Izawa; Jiro Kitaura; Yoshinori Yamanishi; Takayuki Matsuoka; Toshihiko Oki; Fumi Shibata; Hidetoshi Kumagai; Hideaki Nakajima; Mari Maeda-Yamamoto; Jeffrey P Hauchins; Victor L J Tybulewicz; Toshiyuki Takai; Toshio Kitamura
Functional analysis of activating receptor LMIR4 as a counterpart of inhibitory receptor LMIR3.
The Journal of biological chemistry 2007;282(25):17997-8008.
2007: Toshio Kitamura; Naoke Watanabe
[Molecular mechanisms of carcinogenesis: an outline].
Nihon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 1():17-22.
2007: Shan Zhong; Yoshiaki Yogo; Yoshihide Ogawa; Y Oshiro; K Fujimoto; T Kunitake; Huai-Ying Zheng; A Shibuya; Toshio Kitamura
Even distribution of BK polyomavirus subtypes and subgroups in the Japanese Archipelago.
Archives of virology 2007;152(9):1613-21.
2006: Toshiyuki Kawashima; Ying Chun Bao; Yasushi Nomura; Yuseok Moon; Yukio Tonozuka; Yukinori Minoshima; Tomonori Hatori; Akiho Tsuchiya; Mari Kiyono; Tetsuya Nosaka; Hideaki Nakajima; David A Williams; Toshio Kitamura
Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors.
The Journal of cell biology 2006;175(6):937-46.
2006: Keishi Fujio; Akiko Okamoto; Yasuto Araki; Hirofumi Shoda; Hiroyuki Tahara; Nelson H Tsuno; Koki Takahashi; Toshio Kitamura; Kazuhiko Yamamoto
Gene therapy of arthritis with TCR isolated from the inflamed paw.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):8140-7.
2006: Qin Chen; Huai-Ying Zheng; Shan Zhong; Hiroshi Ikegaya; H-X He; W Wei; Y-Y He; N Kobayashi; T Honjo; Tomokazu Takasaka; Shuichiro Takahashi; Toshio Kitamura; Yoshiaki Yogo
Subtype IV of the BK polyomavirus is prevalent in East Asia.
Archives of virology 2006;151(12):2419-29.
2006: Katsutoshi Ozaki; Ai Hishiya; Keiko Hatanaka; Hideaki Nakajima; Gang Wang; Patrick Hwu; Toshio Kitamura; Keiya Ozawa; Warren J Leonard; Tetsuya Nosaka
Overexpression of interleukin 21 induces expansion of hematopoietic progenitor cells.
International journal of hematology 2006;84(3):224-30.
2006: Yoshinosuke Fukuchi; Fumi Shibata; Mamoru Ito; Yuko Goto-Koshino; Yusuke Sotomaru; Mamoru Ito; Toshio Kitamura; Hideaki Nakajima
Comprehensive analysis of myeloid lineage conversion using mice expressing an inducible form of C/EBP alpha.
The EMBO journal 2006;25(14):3398-410.
2006: Hideaki Nakajima; Fumi Shibata; Hidetoshi Kumagai; Kazuya Shimoda; Toshio Kitamura
Tyk2 is dispensable for induction of myeloproliferative disease by mutant FLT3.
International journal of hematology 2006;84(1):54-9.
2006: Hideaki Nakajima; Naohide Watanabe; Fumi Shibata; Toshio Kitamura; Yasuo Ikeda; Makoto Handa
N-terminal region of CCAAT/enhancer-binding protein epsilon is critical for cell cycle arrest, apoptosis, and functional maturation during myeloid differentiation.
The Journal of biological chemistry 2006;281(20):14494-502.
2006: Yusuke Inoue; Arinobu Tojo; Rieko Sekine; Yasushi Soda; Seiichiro Kobayashi; Akiko Nomura; Kiyoko Izawa; Toshio Kitamura; Toshiyuki Okubo; Kuni Ohtomo
In vitro validation of bioluminescent monitoring of disease progression and therapeutic response in leukaemia model animals.
European journal of nuclear medicine and molecular imaging 2006;33(5):557-65.
2006: Hideaki Nakajima; Fumi Shibata; Yoshinosuke Fukuchi; Yuko Goto-Koshino; Miyuki Ito; Atsushi Urano; Tatsutoshi Nakahata; Hiroyuki Aburatani; Toshio Kitamura
Immune suppressor factor confers stromal cell line with enhanced supporting activity for hematopoietic stem cells.
Biochemical and biophysical research communications 2006;340(1):35-42.
2006: Toshihiko Oki; Jiro Kitaura; Koji Eto; Yang Lu; Mari Maeda-Yamamoto; Naoki Inagaki; Hiroichi Nagai; Yoshinori Yamanishi; Hideaki Nakajima; Hideaki Nakajina; Hidetoshi Kumagai; Toshio Kitamura
Integrin alphaIIbbeta3 induces the adhesion and activation of mast cells through interaction with fibrinogen.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):52-60.
2005: Naoto Watanabe; Taisuke Tomita; Chihiro Sato; Toshio Kitamura; Yuichi Morohashi; Takeshi Iwatsubo
Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1.
The Journal of biological chemistry 2005;280(51):41967-75.
2005: Azusa Matsubara; Atsushi Iwama; Satoshi Yamazaki; Chie Furuta; Ryutaro Hirasawa; Yohei Morita; Mitsujiro Osawa; Tsutomu Motohashi; Koji Eto; Hideo Ema; Toshio Kitamura; Dietmar Vestweber; Hiromitsu Nakauchi
Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development.
The Journal of experimental medicine 2005;202(11):1483-92.
2005: Ryoichi Ono; Masafumi Ihara; Hideaki Nakajima; Katsutoshi Ozaki; Yuki Kataoka-Fujiwara; Tomohiko Taki; Koh-Ichi Nagata; Masaki Inagaki; Nobuaki Yoshida; Toshio Kitamura; Yasuhide Hayashi; Makoto Kinoshita; Tetsuya Nosaka
Disruption of Sept6, a fusion partner gene of MLL, does not affect ontogeny, leukemogenesis induced by MLL-SEPT6, or phenotype induced by the loss of Sept4.
Molecular and cellular biology 2005;25(24):10965-78.
2005: Yukinori Minoshima; Tetsuya Hori; Masahiro Okada; Hiroshi Kimura; Tokuko Haraguchi; Yasushi Hiraoka; Ying-Chun Bao; Toshiyuki Kawashima; Toshio Kitamura; Tatsuo Fukagawa
The constitutive centromere component CENP-50 is required for recovery from spindle damage.
Molecular and cellular biology 2005;25(23):10315-28.
2005: Atsushi Urano; Masaki Endoh; Tadashi Wada; Yoshihiro Morikawa; Miyuki Itoh; Yuki Kataoka; Tomohiko Taki; Hiroshi Akazawa; Hideaki Nakajima; Issei Komuro; Nobuaki Yoshida; Yasuhide Hayashi; Hiroshi Handa; Toshio Kitamura; Tetsuya Nosaka
Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia.
Molecular and cellular biology 2005;25(15):6834-45.
2005: Yuko Kato; Atsushi Iwama; Yuko Tadokoro; Kazuya Shimoda; Mayu Minoguchi; Shizuo Akira; Minoru Tanaka; Atsushi Miyajima; Toshio Kitamura; Hiromitsu Nakauchi
Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis.
The Journal of experimental medicine 2005;202(1):169-79.
2005: Hideaki Nakajima; Toshio Kitamura
[Cytokine receptors and signal transduction].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 4():178-86.
2005: Ryoichi Ono; Hideaki Nakajima; Katsutoshi Ozaki; Hidetoshi Kumagai; Toshiyuki Kawashima; Tomohiko Taki; Toshio Kitamura; Yasuhide Hayashi; Tetsuya Nosaka
Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple-lineage leukemogenesis.
The Journal of clinical investigation 2005;115(4):919-29.
2005: Yumiko Oishi; Ichiro Manabe; Kazuyuki Tobe; Kensuke Tsushima; Takayuki Shindo; Katsuhito Fujiu; Go Nishimura; Koji Maemura; Toshimasa Yamauchi; Naoto Kubota; Ryo Suzuki; Toshio Kitamura; Shizuo Akira; Takashi Kadowaki; Ryozo Nagai
Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation.
Cell metabolism 2005;1(1):27-39.
2004: Toshiki Tamura; Haruyuki Ariga; Tatsuo Kinashi; Shuichiro Uehara; Takeshi Kikuchi; Makiyo Nakada; Takeshi Tokunaga; Wen Xu; Ai Kariyone; Takashi Saito; Toshio Kitamura; Gavin Maxwell; Satoshi Takaki; Kiyoshi Takatsu
The role of antigenic peptide in CD4+ T helper phenotype development in a T cell receptor transgenic model.
International immunology 2004;16(12):1691-9.
2004: Yukio Tonozuka; Yukinori Minoshima; Ying Chun Bao; Yuseok Moon; Yohei Tsubono; Tomonori Hatori; Hideaki Nakajima; Tetsuya Nosaka; Toshiyuki Kawashima; Toshio Kitamura
A GTPase-activating protein binds STAT3 and is required for IL-6-induced STAT3 activation and for differentiation of a leukemic cell line.
Blood 2004;104(12):3550-7.
2004: Keishi Fujio; Akiko Okamoto; Hiroyuki Tahara; Masaaki Abe; Yi Jiang; Toshio Kitamura; Sachiko Hirose; Kazuhiko Yamamoto
Nucleosome-specific regulatory T cells engineered by triple gene transfer suppress a systemic autoimmune disease.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):2118-25.
2004: Yuichi Ikeda; Yasushi Imai; Hidetoshi Kumagai; Tetsuya Nosaka; Yoshihiro Morikawa; Tomoko Hisaoka; Ichiro Manabe; Koji Maemura; Takashi Nakaoka; Takeshi Imamura; Kohei Miyazono; Issei Komuro; Ryozo Nagai; Toshio Kitamura
Vasorin, a transforming growth factor beta-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(29):10732-7.
2004: Huai-Ying Zheng; Toshio Kitamura; Tomokazu Takasaka; Qin Chen; Yoshiaki Yogo
Unambiguous identification of JC polyomavirus strains transmitted from parents to children.
Archives of virology 2004;149(2):261-73.
2003: Masayuki Arakawa; Masataka Shiozuka; Yuki Nakayama; Takahiko Hara; Masa Hamada; Shin'ichi Kondo; Daishiro Ikeda; Yoshikazu Takahashi; Ryuichi Sawa; Yoshiaki Nonomura; Kianoush Sheykholeslami; Kenji Kondo; Kimitaka Kaga; Toshio Kitamura; Yuko Suzuki-Miyagoe; Shin'ichi Takeda; Ryoichi Matsuda
Negamycin restores dystrophin expression in skeletal and cardiac muscles of mdx mice.
Journal of biochemistry 2003;134(5):751-8.
2003: Toshio Kitamura; Yuko Koshino; Fumi Shibata; Toshihiko Oki; Hideaki Nakajima; Tetsuya Nosaka; Hidetoshi Kumagai
Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics.
Experimental hematology 2003;31(11):1007-14.
2003: Ken Murata; Hidetoshi Kumagai; Toshiyuki Kawashima; Kaori Tamitsu; Mariko Irie; Hideaki Nakajima; Shinya Suzu; Masabumi Shibuya; Shimeru Kamihira; Tetsuya Nosaka; Shigetaka Asano; Toshio Kitamura
Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3).
The Journal of biological chemistry 2003;278(35):32892-8.
2003: Hiroyuki Tahara; Keishi Fujio; Yasuto Araki; Kiyoshi Setoguchi; Yoshikata Misaki; Toshio Kitamura; Kazuhiko Yamamoto
Reconstitution of CD8+ T cells by retroviral transfer of the TCR alpha beta-chain genes isolated from a clonally expanded P815-infiltrating lymphocyte.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):2154-60.
2003: Hidetoshi Kumagai; Toshihiko Oki; Kaori Tamitsu; Si-zhou Feng; Masao Ono; Hideaki Nakajima; Ying Chun Bao; Yuko Kawakami; Kazunari Nagayoshi; Neal G Copeland; Debra J Gilbert; Nancy A Jenkins; Toshiaki Kawakami; Toshio Kitamura
Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells.
Biochemical and biophysical research communications 2003;307(3):719-29.
2003: Ying-Chun Bao; Hiromichi Tsuruga; Momoki Hirai; Kazuki Yasuda; Norihide Yokoi; Toshio Kitamura; Hidetoshi Kumagai
Identification of a human cDNA sequence which encodes a novel membrane-associated protein containing a zinc metalloprotease motif.
DNA research : an international journal for rapid publication of reports on genes and genomes 2003;10(3):123-8.
2003: Toshimasa Yamauchi; Junji Kamon; Yusuke Ito; Atsushi Tsuchida; Takehiko Yokomizo; Shunbun Kita; Takuya Sugiyama; Makoto Miyagishi; Kazuo Hara; Masaki Tsunoda; Koji Murakami; Toshiaki Ohteki; Shoko Uchida; Sato Takekawa; Hironori Waki; Nelson H Tsuno; Yoichi Shibata; Yasuo Terauchi; philippe froguel; Kazuyuki Tobe; Shigeo Koyasu; Kazunari Taira; Toshio Kitamura; Takao Shimizu; Ryozo Nagai; Takashi Kadowaki
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.
Nature 2003;423(6941):762-9.
2003: Yukinori Minoshima; Toshiyuki Kawashima; Koichi Hirose; Yukio Tonozuka; Aie Kawajiri; Ying Chun Bao; Xingming Deng; Masaaki Tatsuka; Shuh Narumiya; W Stratford May; Tetsuya Nosaka; Kentaro Semba; takafumi inoue; Takaya Satoh; Masaki Inagaki; Toshio Kitamura
Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis.
Developmental cell 2003;4(4):549-60.
2003: Tetsuya Nosaka; Sumiyo Morita; Hidetomo Kitamura; Hideaki Nakajima; Fumi Shibata; Yoshihiro Morikawa; Yuki Kataoka; Yasuhiro Ebihara; Toshiyuki Kawashima; Tsuneo Itoh; Katsutoshi Ozaki; Emiko Senba; Kohichiro Tsuji; Fusao Makishima; Nobuaki Yoshida; Toshio Kitamura
Mammalian twisted gastrulation is essential for skeleto-lymphogenesis.
Molecular and cellular biology 2003;23(8):2969-80.
2003: Takeaki Ozawa; Yusuke Sako; Moritoshi Sato; Toshio Kitamura; Yoshio Umezawa
A genetic approach to identifying mitochondrial proteins.
Nature biotechnology 2003;21(3):287-93.
2002: Tetsuya Nosaka; Toshio Kitamura
Pim-1 expression is sufficient to induce cytokine independence in murine hematopoietic cells, but is dispensable for BCR-ABL-mediated transformation.
Experimental hematology 2002;30(7):697-702.
2002: Yoshinori Nagai; Sachiko Akashi; Masakazu Nagafuku; Masato Ogata; Yoichiro Iwakura; Shizuo Akira; Toshio Kitamura; Atsushi Kosugi; Masao Kimoto; Kensuke Miyake
Essential role of MD-2 in LPS responsiveness and TLR4 distribution.
Nature immunology 2002;3(7):667-72.
2002: Tetsuya Nakamura; Rika Ouchida; Tsunenori Kodama; Toshiyuki Kawashima; Yuichi Makino; Noritada Yoshikawa; Sumiko Watanabe; Chikao Morimoto; Toshio Kitamura; Hirotoshi Tanaka
Cytokine receptor common beta subunit-mediated STAT5 activation confers NF-kappa B activation in murine proB cell line Ba/F3 cells.
The Journal of biological chemistry 2002;277(8):6254-65.
2002: Edgardo E Tulin; Nobuhisa Onoda; Masakazu Hasegawa; Hitoshi Nomura; Toshio Kitamura
Inhibition of human endothelial cell proliferation by ShIF, a vacuolar H(+)-ATPase-like protein.
Oncogene 2002;21(5):844-8.
2002: Edgardo E Tulin; Nobuhisa Onoda; Masakazu Hasegawa; Tetsuya Nosaka; Hitoshi Nomura; Toshio Kitamura
Genetic approach and phenotype-based complementation screening for identification of stroma cell-derived proteins involved in cell proliferation.
Experimental cell research 2002;272(1):23-31.
2001: Tetsuya Fujimura; Shuji Takahashi; Tomohiko Urano; Seishi Ogawa; Yasuyoshi Ouchi; Toshio Kitamura; Masami Muramatsu; Satoshi Inoue
Differential expression of estrogen receptor beta (ERbeta) and its C-terminal truncated splice variant ERbetacx as prognostic predictors in human prostatic cancer.
Biochemical and biophysical research communications 2001;289(3):692-9.
2001: Toshio Kitamura; Toshiyuki Kawashima; Yukinori Minoshima; Yukio Tonozuka; Kenzo Hirose; Tetsuya Nosaka
Role of MgcRacGAP/Cyk4 as a regulator of the small GTPase Rho family in cytokinesis and cell differentiation.
Cell structure and function 2001;26(6):645-51.
2001: Edgardo E Tulin; Nobuhisa Onoda; Y Nakata; M Maeda; Masakazu Hasegawa; Hitoshi Nomura; Toshio Kitamura
SF20/IL-25, a novel bone marrow stroma-derived growth factor that binds to mouse thymic shared antigen-1 and supports lymphoid cell proliferation.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(11):6338-47.
2001: Toshiyuki Kawashima; K Murata; Shizuo Akira; Yukio Tonozuka; Yukinori Minoshima; S Feng; Hidetoshi Kumagai; Hiromichi Tsuruga; Yasuo Ikeda; Shigetaka Asano; Tetsuya Nosaka; Toshio Kitamura
STAT5 induces macrophage differentiation of M1 leukemia cells through activation of IL-6 production mediated by NF-kappaB p65.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(7):3652-60.
2001: Edgardo E Tulin; Nobuhisa Onoda; M Maeda; Masakazu Hasegawa; Tetsuya Nosaka; Hitoshi Nomura; Shigetaka Asano; Toshio Kitamura
A novel secreted form of immune suppressor factor with high homology to vacuolar ATPases identified by a forward genetic approach of functional screening based on cell proliferation.
The Journal of biological chemistry 2001;276(29):27519-26.
2001: Kenzo Hirose; Toshiyuki Kawashima; I Iwamoto; Tetsuya Nosaka; Toshio Kitamura
MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody.
The Journal of biological chemistry 2001;276(8):5821-8.
2001: Yukio Tonozuka; Keishi Fujio; T Sugiyama; Tetsuya Nosaka; Momoki Hirai; Toshio Kitamura
Molecular cloning of a human novel type I cytokine receptor related to delta1/TSLPR.
Cytogenetics and cell genetics 2001;93(1-2):23-5.
2000: Yoshikata Misaki; Kiyoshi Setoguchi; Yasuto Araki; Keishi Fujio; Kimito Kawahata; Toshio Kitamura; Kazuhiko Yamamoto
[Antigen-specific T cells transduced with interleukin-10 ameliorate experimentally induced arthritis without impairing the systemic immune response to the antigen].
Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology 2000;23(6):538-41.
2000: Kiyoshi Setoguchi; Yoshikata Misaki; Yasuto Araki; Keishi Fujio; Kimito Kawahata; Toshio Kitamura; Kazuhiko Yamamoto
Antigen-specific T cells transduced with IL-10 ameliorate experimentally induced arthritis without impairing the systemic immune response to the antigen.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5980-6.
2000: Toshiyuki Kawashima; Kenzo Hirose; T Satoh; Azusa Kaneko; Yasuo Ikeda; Yoshito Kaziro; Tetsuya Nosaka; Toshio Kitamura
MgcRacGAP is involved in the control of growth and differentiation of hematopoietic cells.
Blood 2000;96(6):2116-24.
2000: Nobuyuki Onai; Y y Zhang; Hiroyuki Yoneyama; Toshio Kitamura; S Ishikawa; Kouji Matsushima
Impairment of lymphopoiesis and myelopoiesis in mice reconstituted with bone marrow-hematopoietic progenitor cells expressing SDF-1-intrakine.
Blood 2000;96(6):2074-80.
2000: K Ariyoshi; Tetsuya Nosaka; K Yamada; M Onishi; Yoshitaka Oka; Atsushi Miyajima; Toshio Kitamura
Constitutive activation of STAT5 by a point mutation in the SH2 domain.
The Journal of biological chemistry 2000;275(32):24407-13.
2000: T Kojima; Y Morikawa; Neal G Copeland; D J Gilbert; N A Jenkins; E Senba; Toshio Kitamura
TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles.
The Journal of biological chemistry 2000;275(27):20742-7.
2000: Keishi Fujio; Yoshikata Misaki; Kiyoshi Setoguchi; S Morita; Kimito Kawahata; I Kato; Tetsuya Nosaka; Kazuhiko Yamamoto; Toshio Kitamura
Functional reconstitution of class II MHC-restricted T cell immunity mediated by retroviral transfer of the alpha beta TCR complex.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):528-32.
2000: Tetsuya Nosaka; Toshio Kitamura
Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) in hematopoietic cells.
International journal of hematology 2000;71(4):309-19.
2000: Hiromichi Tsuruga; Hidetoshi Kumagai; T Kojima; Toshio Kitamura
Identification of novel membrane and secreted proteins upregulated during adipocyte differentiation.
Biochemical and biophysical research communications 2000;272(1):293-7.
2000: Takumi Takeuchi; H Nishimatsu; T Ueki; T Kajiwara; H Fukuhara; T Ishida; Nobuo Moriyama; Toshio Kitamura
Differentially expressed mRNAs in androgen-independent but not androgen-dependent Shionogi carcinoma.
Urological research 2000;28(2):82-5.
2000: Keishi Fujio; Tetsuya Nosaka; T Kojima; Toshiyuki Kawashima; T Yahata; Neal G Copeland; D J Gilbert; N A Jenkins; Kazuhiko Yamamoto; T Nishimura; Toshio Kitamura
Molecular cloning of a novel type 1 cytokine receptor similar to the common gamma chain.
Blood 2000;95(7):2204-10.
2000: K Misawa; Tetsuya Nosaka; S Morita; A Kaneko; Tatsutoshi Nakahata; Shigetaka Asano; Toshio Kitamura
A method to identify cDNAs based on localization of green fluorescent protein fusion products.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3062-6.
2000: Atsushi Kato; Chie Sugimoto; Huai-Ying Zheng; Toshio Kitamura; Yoshiaki Yogo
Lack of disease-specific amino acid changes in the viral proteins of JC virus isolates from the brain with progressive multifocal leukoencephalopathy.
Archives of virology 2000;145(10):2173-82.
2000: K Misawa; Tetsuya Nosaka; T Kojima; Momoki Hirai; Toshio Kitamura
Molecular cloning and characterization of a mouse homolog of human TNFSF14, a member of the TNF superfamily.
Cytogenetics and cell genetics 2000;89(1-2):89-91.
2000: K Yamada; K Ariyoshi; M Onishi; Atsushi Miyajima; F Hayakawa; M Towatari; H Saito; Yoshitaka Oka; Shigetaka Asano; Tetsuya Nosaka; Toshio Kitamura
Constitutively active STAT5A and STAT5B in vitro and in vivo: mutation of STAT5 is not a frequent cause of leukemogenesis.
International journal of hematology 2000;71(1):46-54.
1999: Toshio Kitamura; Naomi Tanaka; J Watanabe; Shiro Kanegasaki; Yasuaki Yamada; Koh Nakata
Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte/macrophage colony-stimulating factor.
The Journal of experimental medicine 1999;190(6):875-80.
1999: Tetsuya Nosaka; Toshiyuki Kawashima; K Misawa; Kazuyoshi Ikuta; A L Mui; Toshio Kitamura
STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells.
The EMBO journal 1999;18(17):4754-65.
1999: T Kojima; Toshio Kitamura
A signal sequence trap based on a constitutively active cytokine receptor.
Nature biotechnology 1999;17(5):487-90.
1999: R Mukasa; T Homma; T Ohtsuki; Osamu Hosono; A Souta; Toshio Kitamura; M Fukuda; S Watanabe; Chikao Morimoto
Core 2-containing O-glycans on CD43 are preferentially expressed in the memory subset of human CD4 T cells.
International immunology 1999;11(2):259-68.
1999: Naomi Tanaka; J Watanabe; Toshio Kitamura; Yasuaki Yamada; Shiro Kanegasaki; Koh Nakata
Lungs of patients with idiopathic pulmonary alveolar proteinosis express a factor which neutralizes granulocyte-macrophage colony stimulating factor.
FEBS letters 1999;442(2-3):246-50.
1999: Tsutomu Takeuchi; T Ueki; Hiroaki Nishimatsu; T Kajiwara; T Ishida; Kou-ichi Jishage; Otoya Ueda; H Suzuki; B Li; N Moriyama; Toshio Kitamura
Accelerated rejection of Fas ligand-expressing heart grafts.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):518-22.
1998: Jing Guo; Chie Sugimoto; Toshio Kitamura; Hideki Ebihara; Atsushi Kato; Z Guo; J Liu; S P Zheng; Y L Wang; Y Q Na; Masashi Suzuki; Fumiaki Taguchi; Yoshiaki Yogo
Four geographically distinct genotypes of JC virus are prevalent in China and Mongolia: implications for the racial composition of modern China.
The Journal of general virology 1998;79 ( Pt 10)():2499-505.
1998: S Kameyama; S Yamazaki; Toshio Kitamura
[Surgical or medical castration with LH-RH analogue for prostatic cancer].
Nihon rinsho. Japanese journal of clinical medicine 1998;56(8):2114-8.
1998: Toshio Kitamura
New experimental approaches in retrovirus-mediated expression screening.
International journal of hematology 1998;67(4):351-9.
1998: M Onishi; Tetsuya Nosaka; Toshio Kitamura
Cytokine receptors: structures and signal transduction.
International reviews of immunology 1998;16(5-6):617-34.
1997: Chie Sugimoto; Toshio Kitamura; Jing Guo; Mohammed N Al-Ahdal; S N Shchelkunov; B Otova; P Ondrejka; J Y Chollet; S El-Safi; M Ettayebi; G Grésenguet; T Kocagöz; S Chaiyarasamee; Kyaw-Zin Thant; S Thein; K Moe; Nobuyoshi Kobayashi; Fumiaki Taguchi; Yoshiaki Yogo
Typing of urinary JC virus DNA offers a novel means of tracing human migrations.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9191-6.
1997: Toshio Kitamura; Chie Sugimoto; Atsushi Kato; Hideki Ebihara; Masashi Suzuki; Fumiaki Taguchi; K Kawabe; Yoshiaki Yogo
Persistent JC virus (JCV) infection is demonstrated by continuous shedding of the same JCV strains.
Journal of clinical microbiology 1997;35(5):1255-7.
1997: Atsushi Kato; Toshio Kitamura; Chie Sugimoto; Yoshihide Ogawa; K Nakazato; Kazuo Nagashima; W W Hall; K Kawabe; Yoshiaki Yogo
Lack of evidence for the transmission of JC polyomavirus between human populations.
Archives of virology 1997;142(5):875-82.