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Hiroshi Kiwada

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Ishihara Tsutomu; Takeda Miho; Sakamoto Haruka; Kimoto Ayumi; Kobayashi Chisa; Takasaki Naoko; Yuki Kanae; Tanaka Ken-ichiro; Takenaga Mitsuko; Igarashi Rie; Maeda Taishi; Yamakawa Naoki; Okamoto Yoshinari; Otsuka Masami; Ishida Tatsuhiro; Kiwada Hiroshi; Mizushima Yutaka; Mizushima Tohru
Accelerated blood clearance phenomenon upon repeated injection of PEG-modified PLA-nanoparticles.
Yamazaki Hiroyuki; Miyake Masateru; Nishibayashi Toru; Mukai Tadashi; Odomi Masaaki; Ishida Tatsuhiro; Kiwada Hiroshi
Effect of co-administration of tacrolimus on the pharmacokinetics of multiple subcutaneous administered interferon-alpha in rats.
Tagami Tatsuaki; Nakamura Kazuya; Shimizu Taro; Ishida Tatsuhiro; Kiwada Hiroshi
Effect of siRNA in PEG-coated siRNA-lipoplex on anti-PEG IgM production.

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All Publications

2009: Ishihara Tsutomu; Takeda Miho; Sakamoto Haruka; Kimoto Ayumi; Kobayashi Chisa; Takasaki Naoko; Yuki Kanae; Tanaka Ken-ichiro; Takenaga Mitsuko; Igarashi Rie; Maeda Taishi; Yamakawa Naoki; Okamoto Yoshinari; Otsuka Masami; Ishida Tatsuhiro; Kiwada Hiroshi; Mizushima Yutaka; Mizushima Tohru
Accelerated blood clearance phenomenon upon repeated injection of PEG-modified PLA-nanoparticles.
Pharmaceutical research 2009;26(10):2270-9.
2009: Yamazaki Hiroyuki; Miyake Masateru; Nishibayashi Toru; Mukai Tadashi; Odomi Masaaki; Ishida Tatsuhiro; Kiwada Hiroshi
Effect of co-administration of tacrolimus on the pharmacokinetics of multiple subcutaneous administered interferon-alpha in rats.
Pharmaceutical research 2009;26(8):1832-7.
2009: Tagami Tatsuaki; Nakamura Kazuya; Shimizu Taro; Ishida Tatsuhiro; Kiwada Hiroshi
Effect of siRNA in PEG-coated siRNA-lipoplex on anti-PEG IgM production.
Journal of controlled release : official journal of the Controlled Release Society 2009;137(3):234-40.
2009: Abu Lila Amr S; Kizuki Shinji; Doi Yusuke; Suzuki Takuya; Ishida Tatsuhiro; Kiwada Hiroshi
Oxaliplatin encapsulated in PEG-coated cationic liposomes induces significant tumor growth suppression via a dual-targeting approach in a murine solid tumor model.
Journal of controlled release : official journal of the Controlled Release Society 2009;137(1):8-14.
2009: Isakari Yoshimasa; Sogo Shinji; Ishida Tatsuhiro; Kawakami Takuma; Ono Toshihide; Taki Takao; Kiwada Hiroshi
Gene expression analysis during platelet-like particle production in phorbol myristate acetate-treated MEG-01 cells.
Biological & pharmaceutical bulletin 2009;32(3):354-8.
2009: Ishida Tatsuhiro; Shiraga Emi; Kiwada Hiroshi
Synergistic antitumor activity of metronomic dosing of cyclophosphamide in combination with doxorubicin-containing PEGylated liposomes in a murine solid tumor model.
Journal of controlled release : official journal of the Controlled Release Society 2009;134(3):194-200.
2009: Abu-Lila Amr; Suzuki Takuya; Doi Yusuke; Ishida Tatsuhiro; Kiwada Hiroshi
Oxaliplatin targeting to angiogenic vessels by PEGylated cationic liposomes suppresses the angiogenesis in a dorsal air sac mouse model.
Journal of controlled release : official journal of the Controlled Release Society 2009;134(1):18-25.
2008: Tagami Tatsuaki; Hirose Kiyomi; Barichello Jose Mario; Ishida Tatsuhiro; Kiwada Hiroshi
Global gene expression profiling in cultured cells is strongly influenced by treatment with siRNA-cationic liposome complexes.
Pharmaceutical research 2008;25(11):2497-504.
2008: Koide Hiroyuki; Asai Tomohiro; Hatanaka Kentaro; Urakami Takeo; Ishii Takayuki; Kenjo Eriya; Nishihara Masamichi; Yokoyama Masayuki; Ishida Tatsuhiro; Kiwada Hiroshi; Oku Naoto
Particle size-dependent triggering of accelerated blood clearance phenomenon.
International journal of pharmaceutics 2008;362(1-2):197-200.
2008: Barichello José Mario; Yamakawa Noriko; Kisyuku Masatoshi; Handa Hiroshi; Shibata Taiki; Ishida Tatsuhiro; Kiwada Hiroshi
Combined effect of liposomalization and addition of glycerol on the transdermal delivery of isosorbide 5-nitrate in rat skin.
International journal of pharmaceutics 2008;357(1-2):199-205.
2008: Matsumura-Takeda Kuniko; Ishida Tatsuhiro; Sogo Shinji; Isakari Yoshimasa; Taki Takao; Sudo Toshiki; Kiwada Hiroshi
Lactoferrin inhibits platelet production from human megakaryocytes in vitro.
Biological & pharmaceutical bulletin 2008;31(4):569-73.
2008: Asai Tomohiro; Suzuki Yuko; Matsushita Saori; Yonezawa Sei; Yokota Junichi; Katanasaka Yasufumi; Ishida Tatsuhiro; Dewa Takehisa; Kiwada Hiroshi; Nango Mamoru; Oku Naoto
Disappearance of the angiogenic potential of endothelial cells caused by Argonaute2 knockdown.
Biochemical and biophysical research communications 2008;368(2):243-8.
2008: Shiraga Emi; Barichello Jose Mario; Ishida Tatsuhiro; Kiwada Hiroshi
A metronomic schedule of cyclophosphamide combined with PEGylated liposomal doxorubicin has a highly antitumor effect in an experimental pulmonary metastatic mouse model.
International journal of pharmaceutics 2008;353(1-2):65-73.
2008: Ishida Tatsuhiro; Kiwada Hiroshi
Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes.
International journal of pharmaceutics 2008;354(1-2):56-62.
2008: Ishida Tatsuhiro; Kashima Syuntaro; Kiwada Hiroshi
The contribution of phagocytic activity of liver macrophages to the accelerated blood clearance (ABC) phenomenon of PEGylated liposomes in rats.
Journal of controlled release : official journal of the Controlled Release Society 2008;126(2):162-5.
2008: Ishida Tatsuhiro; Kiwada Hiroshi
[Accelerated blood clearance (ABC) phenomenon induced by administration of PEGylated liposome]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2008;128(2):233-43.
2007: Ishida Tatsuhiro; Wang Xinyu; Shimizu Taro; Nawata Kosuke; Kiwada Hiroshi
PEGylated liposomes elicit an anti-PEG IgM response in a T cell-independent manner.
Journal of controlled release : official journal of the Controlled Release Society 2007;122(3):349-55.
2007: Hatakeyama Hiroto; Akita Hidetaka; Ishida Emi; Hashimoto Koichi; Kobayashi Hideo; Aoki Takanori; Yasuda Junko; Obata Kenichi; Kikuchi Hiroshi; Ishida Tatsuhiro; Kiwada Hiroshi; Harashima Hideyoshi
Tumor targeting of doxorubicin by anti-MT1-MMP antibody-modified PEG liposomes.
International journal of pharmaceutics 2007;342(1-2):194-200.
2007: Wang XinYu; Ishida Tatsuhiro; Kiwada Hiroshi
Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes.
Journal of controlled release : official journal of the Controlled Release Society 2007;119(2):236-44.
2007: Isakari Yoshimasa; Harada Yasuo; Ishikawa Dai; Matsumura-Takeda Kuniko; Sogo Shinji; Ishida Tatsuhiro; Taki Takao; Kiwada Hiroshi
Efficient gene expression in megakaryocytic cell line using nucleofection.
International journal of pharmaceutics 2007;338(1-2):157-64.
2007: Atobe Kazutaka; Ishida Tatsuhiro; Ishida Emi; Hashimoto Kouichi; Kobayashi Hideo; Yasuda Jyunko; Aoki Takanori; Obata Ken-Ichi; Kikuchi Hiroshi; Akita Hidetaka; Asai Tomohiro; Harashima Hideyoshi; Oku Naoto; Kiwada Hiroshi
In vitro efficacy of a sterically stabilized immunoliposomes targeted to membrane type 1 matrix metalloproteinase (MT1-MMP).
Biological & pharmaceutical bulletin 2007;30(5):972-8.
2007: Nguyen Lap Thi; Atobe Kazutaka; Barichello Jose Mario; Ishida Tatsuhiro; Kiwada Hiroshi
Complex formation with plasmid DNA increases the cytotoxicity of cationic liposomes.
Biological & pharmaceutical bulletin 2007;30(4):751-7.
2007: Tagami Tatsuaki; Barichello Jose Mario; Kikuchi Hiroshi; Ishida Tatsuhiro; Kiwada Hiroshi
The gene-silencing effect of siRNA in cationic lipoplexes is enhanced by incorporating pDNA in the complex.
International journal of pharmaceutics 2007;333(1-2):62-9.
2007: Kobayashi Tomotaka; Ishida Tatsuhiro; Okada Yurie; Ise Saori; Harashima Hideyoshi; Kiwada Hiroshi
Effect of transferrin receptor-targeted liposomal doxorubicin in P-glycoprotein-mediated drug resistant tumor cells.
International journal of pharmaceutics 2007;329(1-2):94-102.
2006: Ishida Tatsuhiro; Atobe Kazutaka; Wang XingYu; Kiwada Hiroshi
Accelerated blood clearance of PEGylated liposomes upon repeated injections: effect of doxorubicin-encapsulation and high-dose first injection.
Journal of controlled release : official journal of the Controlled Release Society 2006;115(3):251-8.
2006: Ishida Tatsuhiro; Ichihara Masako; Wang XinYu; Kiwada Hiroshi
Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes.
Journal of controlled release : official journal of the Controlled Release Society 2006;115(3):243-50.
2006: Barichello José Mario; Handa Hiroshi; Kisyuku Masatoshi; Shibata Taiki; Ishida Tatsuhiro; Kiwada Hiroshi
Inducing effect of liposomalization on the transdermal delivery of hydrocortisone: creation of a drug supersaturated state.
Journal of controlled release : official journal of the Controlled Release Society 2006;115(1):94-102.
2006: Dang Fuquan; Li Wenhao; Zhang Lihua; Jabasini Mohammad; Ishida Tatsuhiro; Kiwada Hiroshi; Kaji Noritada; Tokeshi Manabu; Baba Yoshinobu
Electrophoretic behavior of plasmid DNA in the presence of various intercalating dyes.
Journal of chromatography. A 2006;1118(2):218-25.
2006: Ishida Tatsuhiro; Ichihara Masako; Wang XinYu; Yamamoto Kenji; Kimura Junji; Majima Eiji; Kiwada Hiroshi
Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes.
Journal of controlled release : official journal of the Controlled Release Society 2006;112(1):15-25.
2006: Ishida Tatsuhiro; Takanashi Yoshihiro; Kiwada Hiroshi
Safe and efficient drug delivery system with liposomes for intrathecal application of an antivasospastic drug, fasudil.
Biological & pharmaceutical bulletin 2006;29(3):397-402.
2006: Ishida Tatsuhiro; Li Wenhao; Liu Zhihui; Kiwada Hiroshi
Stimulatory effect of polyethylene glycol (PEG) on gene expression in mouse liver following hydrodynamics-based transfection.
The journal of gene medicine 2006;8(3):324-34.
2006: Ishida Tatsuhiro; Okada Yurie; Kobayashi Tomotaka; Kiwada Hiroshi
Development of pH-sensitive liposomes that efficiently retain encapsulated doxorubicin (DXR) in blood.
International journal of pharmaceutics 2006;309(1-2):94-100.
2005: Nguyen Lap Thi; Ishida Tatsuhiro; Kiwada Hiroshi
Gene expression in primary cultured mouse hepatocytes with a cationic liposomal vector, TFL-3: comparison with rat hepatocytes.
Biological & pharmaceutical bulletin 2005;28(8):1472-5.
2005: Ishida Tatsuhiro; Harada Masae; Wang Xin Yu; Ichihara Masako; Irimura Kenji; Kiwada Hiroshi
Accelerated blood clearance of PEGylated liposomes following preceding liposome injection: effects of lipid dose and PEG surface-density and chain length of the first-dose liposomes.
Journal of controlled release : official journal of the Controlled Release Society 2005;105(3):305-17.
2005: Wang Xin Yu; Ishida Tatsuhiro; Ichihara Masako; Kiwada Hiroshi
Influence of the physicochemical properties of liposomes on the accelerated blood clearance phenomenon in rats.
Journal of controlled release : official journal of the Controlled Release Society 2005;104(1):91-102.
2005: Li Wenhao; Ishida Tatsuhiro; Okada Yurie; Oku Naoto; Kiwada Hiroshi
Increased gene expression by cationic liposomes (TFL-3) in lung metastases following intravenous injection.
Biological & pharmaceutical bulletin 2005;28(4):701-6.
2004: Li Wenhao; Ishida Tatsuhiro; Tachibana Rieko; Almofti Mohamad Radwan; Wang Xinyu; Kiwada Hiroshi
Cell type-specific gene expression, mediated by TFL-3, a cationic liposomal vector, is controlled by a post-transcription process of delivered plasmid DNA.
International journal of pharmaceutics 2004;276(1-2):67-74.
2004: Ishida Tatsuhiro; Ichikawa Takako; Ichihara Masako; Sadzuka Yasuyuki; Kiwada Hiroshi
Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice.
Journal of controlled release : official journal of the Controlled Release Society 2004;95(3):403-12.
2004: Tachibana Rieko; Ide Naoko; Shinohara Yasuo; Harashima Hideyoshi; Hunt C Anthony; Kiwada Hiroshi
An assessment of relative transcriptional availability from nonviral vectors.
International journal of pharmaceutics 2004;270(1-2):315-21.
2003: Nguyen Lap Thi; Ishida Tatsuhiro; Ukitsu Sachiko; Li Wen Hao; Tachibana Rieko; Kiwada Hiroshi
Culture time-dependent gene expression in isolated primary cultured rat hepatocytes by transfection with the cationic liposomal vector TFL-3.
Biological & pharmaceutical bulletin 2003;26(6):880-5.
2003: Ishida Tatsuhiro; Masuda Kaori; Ichikawa Takako; Ichihara Masako; Irimura Kenji; Kiwada Hiroshi
Accelerated clearance of a second injection of PEGylated liposomes in mice.
International journal of pharmaceutics 2003;255(1-2):167-74.
2003: Ishida Tatsuhiro; Maeda Ryuhei; Ichihara Masako; Irimura Kenji; Kiwada Hiroshi
Accelerated clearance of PEGylated liposomes in rats after repeated injections.
Journal of controlled release : official journal of the Controlled Release Society 2003;88(1):35-42.
2003: Almofti Mohamad Radwan; Harashima Hideyoshi; Shinohara Yasuo; Almofti Ammar; Baba Yoshinobu; Kiwada Hiroshi
Cationic liposome-mediated gene delivery: biophysical study and mechanism of internalization.
Archives of biochemistry and biophysics 2003;410(2):246-53.
2003: Almofti Mohamad Radwan; Harashima Hideyoshi; Shinohara Yasuo; Almofti Ammar; Li Wenhao; Kiwada Hiroshi
Lipoplex size determines lipofection efficiency with or without serum.
Molecular membrane biology 2003;20(1):35-43.
2003: Tachibana Rieko; Futaki Shiroh; Harashima Hideyoshi; Kiwada Hiroshi
pH-sensitive liposomes in nuclear targeting of macromolecules.
Methods in enzymology 2003;372():349-61.
2002: Ishida Tatsuhiro; Harashima Hideyoshi; Kiwada Hiroshi
Liposome clearance.
Bioscience reports 2002;22(2):197-224.
2002: Tachibana Rieko; Harashima Hideyoshi; Ide Naoko; Ukitsu Sachiko; Ohta Yasuko; Suzuki Norio; Kikuchi Hiroshi; Shinohara Yasuo; Kiwada Hiroshi
Quantitative analysis of correlation between number of nuclear plasmids and gene expression activity after transfection with cationic liposomes.
Pharmaceutical research 2002;19(4):377-81.
2002: Tachibana Rieko; Harashima Hideyoshi; Ishida Tatsuhiro; Shinohara Yasuo; Hino Mami; Terada Hiroshi; Baba Yoshinobu; Kiwada Hiroshi
Effect of cationic liposomes in an in vitro transcription and translation system.
Biological & pharmaceutical bulletin 2002;25(4):529-31.
2002: Yamamoto Sayaka; Ishida Tatsuhiro; Inoue Akiko; Mikami Junko; Muraguchi Masahiro; Ohmoto Yasukazu; Kiwada Hiroshi
HEPC-based liposomes trigger cytokine release from peripheral blood cells: effects of liposomal size, dose and lipid composition.
International journal of pharmaceutics 2002;236(1-2):125-33.
2002: Ishida Tatsuhiro; Takanashi Yoshihiro; Doi Hisako; Yamamoto Isao; Kiwada Hiroshi
Encapsulation of an antivasospastic drug, fasudil, into liposomes, and in vitro stability of the fasudil-loaded liposomes.
International journal of pharmaceutics 2002;232(1-2):59-67.
2002: Azuma Ryotaro; Komuro Masahito; Kawaguchi Yasuro; Okudaira Kazuho; Hayashi Masahiro; Kiwada Hiroshi
Comparative analysis of in vitro and in vivo pharmacokinetic parameters related to individual variability of GTS-21 in canine.
Drug metabolism and pharmacokinetics 2002;17(1):75-82.
2002: Harashima Hideyoshi; Ishida Tatsuhiro; Kamiya Hiroyuki; Kiwada Hiroshi
Pharmacokinetics of targeting with liposomes.
Critical reviews in therapeutic drug carrier systems 2002;19(3):235-75.
2002: Ishida Tatsuhiro; Maeda Ryuhei; Ichihara Masako; Mukai Yasuko; Motoki Yoko; Manabe Yoshie; Irimura Kenji; Kiwada Hiroshi
The accelerated clearance on repeated injection of pegylated liposomes in rats: laboratory and histopathological study.
Cellular & molecular biology letters 2002;7(2):286.
2001: Ishida T; Harashima H; Kiwada H
Interactions of liposomes with cells in vitro and in vivo: opsonins and receptors.
Current drug metabolism 2001;2(4):397-409.
2001: Tachibana R; Harashima H; Shinohara Y; Kiwada H
Quantitative studies on the nuclear transport of plasmid DNA and gene expression employing nonviral vectors.
Advanced drug delivery reviews 2001;52(3):219-26.
2001: Azuma R; Hirota T; Manabe H; Komuro M; Kiwada H
First-pass of GTS-21 on canine gut wall and liver determined by portal-systemic concentration difference.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2001;14(2):159-65.
2001: Ishida T; Yasukawa K; Kojima H; Harashima H; Kiwada H
Effect of cholesterol content in activation of the classical versus the alternative pathway of rat complement system induced by hydrogenated egg phosphatidylcholine-based liposomes.
International journal of pharmaceutics 2001;224(1-2):69-79.
2001: Huong T M; Ishida T; Harashima H; Kiwada H
Species difference in correlation between in vivo/in vitro liposome-complement interactions.
Biological & pharmaceutical bulletin 2001;24(4):439-41.
2001: Harashima H; Shinohara Y; Kiwada H
Intracellular control of gene trafficking using liposomes as drug carriers.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2001;13(1):85-9.
2001: Huong T M; Ishida T; Harashima H; Kiwada H
The complement system enhances the clearance of phosphatidylserine (PS)-liposomes in rat and guinea pig.
International journal of pharmaceutics 2001;215(1-2):197-205.
2000: Ishida T; Kojima H; Harashima H; Kiwada H
Biodistribution of liposomes and C3 fragments associated with liposomes: evaluation of their relationship.
International journal of pharmaceutics 2000;205(1-2):183-93.
1999: Harashima H; Iida S; Urakami Y; Tsuchihashi M; Kiwada H
Optimization of antitumor effect of liposomally encapsulated doxorubicin based on simulations by pharmacokinetic/pharmacodynamic modeling.
Journal of controlled release : official journal of the Controlled Release Society 1999;61(1-2):93-106.
1999: Tsuchihashi M; Harashima H; Kiwada H
Development of a pharmacokinetic/pharmacodynamic (PK/PD)-simulation system for doxorubicin in long circulating liposomes in mice using peritoneal P388.
Journal of controlled release : official journal of the Controlled Release Society 1999;61(1-2):9-19.
1999: Huong T M; Harashima H; Kiwada H
In vivo studies on the role of complement in the clearance of liposomes in rats and guinea pigs.
Biological & pharmaceutical bulletin 1999;22(5):515-20.
1999: Kuwajima M; Harashima H; Hayashi M; Ise S; Sei M; Lu K m; Kiwada H; Sugiyama Y; Shima K
Pharmacokinetic analysis of the cardioprotective effect of 3-(2,2, 2-trimethylhydrazinium) propionate in mice: inhibition of carnitine transport in kidney.
The Journal of pharmacology and experimental therapeutics 1999;289(1):93-102.
1998: Tachibana R; Harashima H; Shono M; Azumano M; Niwa M; Futaki S; Kiwada H
Intracellular regulation of macromolecules using pH-sensitive liposomes and nuclear localization signal: qualitative and quantitative evaluation of intracellular trafficking.
Biochemical and biophysical research communications 1998;251(2):538-44.
1998: Huong T M; Harashima H; Kiwada H
Complement dependent and independent liposome uptake by peritoneal macrophages: cholesterol content dependency.
Biological & pharmaceutical bulletin 1998;21(9):969-73.
1998: Yamada M; Harashima H; Kiwada H
Kinetic analysis of the interaction between liposomes and the complement system in rat serum: re-evaluation of size-dependency.
Biological & pharmaceutical bulletin 1998;21(9):964-8.
1998: Liu S; Ishida T; Kiwada H
Characterization of bovine serum factor triggering the lysis of liposomes via complement activation.
Biological & pharmaceutical bulletin 1998;21(4):390-7.
1997: Liu S; Ishida T; Kiwada H
Effect of serum components from different species on destabilizing hydrogenated phosphatidylcholine-based liposomes.
Biological & pharmaceutical bulletin 1997;20(8):874-80.
1996: Harashima H; Huong T M; Ishida T; Manabe Y; Matsuo H; Kiwada H
Synergistic effect between size and cholesterol content in the enhanced hepatic uptake clearance of liposomes through complement activation in rats.
Pharmaceutical research 1996;13(11):1704-9.
1996: Yachi K; Harashima H; Kikuchi H; Sudo R; Yamauchi H; Ebihara K; Matsuo H; Funato K; Kiwada H
Biopharmaceutical evaluation of the liposomes prepared by rehydration of freeze-dried empty liposomes (FDELs) with an aqueous solution of a drug.
Biopharmaceutics & drug disposition 1996;17(7):589-605.
1996: Harashima H; Komatsu S; Kojima S; Yanagi C; Morioka Y; Naito M; Kiwada H
Species difference in the disposition of liposomes among mice, rats, and rabbits: allometric relationship and species dependent hepatic uptake mechanism.
Pharmaceutical research 1996;13(7):1049-54.
1996: Ferdous A J; Ishida T; Shinohara M; Harashima H; Kiwada H
Size-dependent release of carboxyfluorescein from cetylmannoside-modified liposomes in human plasma.
Biopharmaceutics & drug disposition 1996;17(2):145-54.
1995: Matsuo H; Yamashita C; Akiyama K; Kiwada H
Effect of cetylmannoside modification on the alternative complement pathway activation by liposomes in rat serum.
Biological & pharmaceutical bulletin 1995;18(4):581-5.
1995: Harashima H; Hirai N; Kiwada H
Kinetic modelling of liposome degradation in peritoneal macrophages.
Biopharmaceutics & drug disposition 1995;16(2):113-23.
1995: Harashima H; Hiraiwa T; Ochi Y; Kiwada H
Size dependent liposome degradation in blood: in vivo/in vitro correlation by kinetic modeling.
Journal of drug targeting 1995;3(4):253-61.
1994: Matsuki Y; Bandou R; Kiwada H; Maeda H; Goromaru T
Effects of ascorbic acid on iproniazid-induced hepatitis in phenobarbital-treated rats.
Biological & pharmaceutical bulletin 1994;17(8):1078-82.
1994: Osaka S; Tsuji H; Kiwada H
Uptake of liposomes surface-modified with glycyrrhizin by primary cultured rat hepatocytes.
Biological & pharmaceutical bulletin 1994;17(7):940-3.
1994: Harashima H; Kiwada H; Kajita J; Kobayashi S
Effects of benidipine hydrochloride (Coniel), a new calcium antagonist, on the cardiac output, regional blood flow and vascular resistance in conscious, spontaneously hypertensive rats.
Biopharmaceutics & drug disposition 1994;15(5):431-8.
1994: Harashima H; Ochi Y; Kiwada H
Kinetic modelling of liposome degradation in serum: effect of size and concentration of liposomes in vitro.
Biopharmaceutics & drug disposition 1994;15(3):217-25.
1994: Harashima H; Sakata K; Funato K; Kiwada H
Enhanced hepatic uptake of liposomes through complement activation depending on the size of liposomes.
Pharmaceutical research 1994;11(3):402-6.
1994: Funato K; Yamashita C; Kamada J; Tominaga S; Kiwada H
Plasma factor triggering alternative complement pathway activation by liposomes.
Pharmaceutical research 1994;11(3):372-6.
1994: Matsuo H; Funato K; Harashima H; Kiwada H
The complement- but not mannose receptor-mediated phagocytosis is involved in the hepatic uptake of cetylmannoside-modified liposomes in situ.
Journal of drug targeting 1994;2(2):141-6.
1993: Harashima H; Midori Y; Ohshima S; Yachi K; Kikuchi H; Kiwada H
Kinetic analysis of tissue distribution of doxorubicin incorporated in liposomes in rats (II).
Biopharmaceutics & drug disposition 1993;14(7):595-608.
1993: Harashima H; Yamane C; Kume Y; Kiwada H
Kinetic analysis of AUC-dependent saturable clearance of liposomes: mathematical description of AUC dependency.
Journal of pharmacokinetics and biopharmaceutics 1993;21(3):299-308.
1993: Harashima H; Kume Y; Yamane C; Kiwada H
Kinetic modeling of liposome degradation in blood circulation.
Biopharmaceutics & drug disposition 1993;14(3):265-70.
1993: Harashima H; Sakata K; Kiwada H
Distinction between the depletion of opsonins and the saturation of uptake in the dose-dependent hepatic uptake of liposomes.
Pharmaceutical research 1993;10(4):606-10.
1992: Matsuki Y; Hongu Y; Noda Y; Kiwada H; Sakurai H; Goromaru T
[Effects of ascorbic acid on the metabolic fate and the free radical formation of iproniazid]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1992;112(12):926-33.
1992: Harashima H; Ohnishi Y; Kiwada H
In vivo evaluation of the effect of the size and opsonization on the hepatic extraction of liposomes in rats: an application of Oldendorf method.
Biopharmaceutics & drug disposition 1992;13(7):549-53.
1992: Harashima H; Kume Y; Yamane C; Kiwada H
Non-Michaelis-Menten type hepatic uptake of liposomes in the rat.
The Journal of pharmacy and pharmacology 1992;44(9):707-12.
1992: Harashima H; Ohshima S; Midori Y; Yachi K; Kikuchi H; Kiwada H
Kinetic analysis of tissue distribution of doxorubicin incorporated in liposomes in rats: I.
Biopharmaceutics & drug disposition 1992;13(3):155-70.
1992: Funato K; Yoda R; Kiwada H
Contribution of complement system on destabilization of liposomes composed of hydrogenated egg phosphatidylcholine in rat fresh plasma.
Biochimica et biophysica acta 1992;1103(2):198-204.
1991: Matsuki Y; Akazawa M; Tsuchiya K; Sakurai H; Kiwada H; Goromaru T
[Effects of ascorbic acid on the free radical formations of isoniazid and its metabolites]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1991;111(10):600-5.
1991: Yamashita C; Sone S; Ogura T; Kiwada H
Potential value of cetylmannoside-modified liposomes as carriers of macrophage activators to human blood monocytes.
Japanese journal of cancer research : Gann 1991;82(5):569-76.
1991: Tsuji H; Osaka S; Kiwada H
Targeting of liposomes surface-modified with glycyrrhizin to the liver. I. Preparation and biological disposition.
Chemical & pharmaceutical bulletin 1991;39(4):1004-8.
1991: Kume Y; Maeda F; Harashima H; Kiwada H
Saturable, non-Michaelis-Menten uptake of liposomes by the reticuloendothelial system.
The Journal of pharmacy and pharmacology 1991;43(3):162-6.
1991: Matsuki Y; Katakuse Y; Matsuura H; Kiwada H; Goromaru T
Effects of glucose and ascorbic acid on absorption and first pass metabolism of isoniazid in rats.
Chemical & pharmaceutical bulletin 1991;39(2):445-8.
1989: Tahara K; Hayashi M; Awazu S; Kato Y; Kiwada H
Effect of serum on dose- and temperature-dependent hepatic uptake of multilamellar vesicles (MLV).
Journal of pharmacobio-dynamics 1989;12(10):596-601.

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Hiroshi Kiwada

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