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Hiroshi Kiwada

Research Profile

Chemicals & Drugs

Living Beings

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Metabolic Clearance Rate

Anatomy

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Injections, Intravenous

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Drug Delivery Systems

Physiology

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Publications

TOP 3
Kanae Ichikawa; Tatsuhiro Ishida; Hiroto Kawashima; Hiroshi Kiwada; Haruna Miyauchi; Kosuke Shimizu; Takeo Urakami; Sei Yonezawa; Tomohiro Asai; Naoto Oku
Suppression of immune response by antigen-modified liposomes encapsulating model agents: A novel strategy for the treatment of allergy.
Taro Shimizu; Tatsuhiro Ishida; Hiroshi Kiwada
Transport of PEGylated liposomes from the splenic marginal zone to the follicle in the induction phase of the accelerated blood clearance phenomenon.
Ai Nagao; Amr S Abu Lila; Amr Abu Lila; Hiroshi Kiwada
Abrogation of the accelerated blood clearance phenomenon by SOXL regimen: promise for clinical application.

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All Publications

2013: Kanae Ichikawa; Tatsuhiro Ishida; Hiroto Kawashima; Hiroshi Kiwada; Haruna Miyauchi; Kosuke Shimizu; Takeo Urakami; Sei Yonezawa; Tomohiro Asai; Naoto Oku
Suppression of immune response by antigen-modified liposomes encapsulating model agents: A novel strategy for the treatment of allergy.
Journal of controlled release : official journal of the Controlled Release Society 2013;167(3):284-9.
2013: Taro Shimizu; Tatsuhiro Ishida; Hiroshi Kiwada
Transport of PEGylated liposomes from the splenic marginal zone to the follicle in the induction phase of the accelerated blood clearance phenomenon.
Immunobiology 2013;218(5):725-32.
2013: Ai Nagao; Amr S Abu Lila; Amr Abu Lila; Hiroshi Kiwada
Abrogation of the accelerated blood clearance phenomenon by SOXL regimen: promise for clinical application.
International journal of pharmaceutics 2013;441(1-2):395-401.
2013: Tatsuhiro Ishida; Hiroshi Kiwada
Alteration of tumor microenvironment for improved delivery and intratumor distribution of nanocarriers.
Biological & pharmaceutical bulletin 2013;36(5):692-7.
2013: Tatsuhiro Ishida; Hiroshi Kiwada
[Development of siRNA delivery strategy by active control of tumor microenvironment].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2013;133(3):379-86.
2013: Amr Selim Abu Lila; Amr Abu Lila; Amr S Abu Lila; Naoto Moriyoshi; Hiroshi Kiwada
Anti-PEG IgM production via a PEGylated nano-carrier system for nucleic acid delivery.
Methods in molecular biology (Clifton, N.J.) 2013;948():35-47.
2012: Amr S Abu Lila; Noha Essam Eldin; Amr Selim Abu Lila; Amr Abu Lila; Hiroshi Kiwada
Multiple administration of PEG-coated liposomal oxaliplatin enhances its therapeutic efficacy: a possible mechanism and the potential for clinical application.
International journal of pharmaceutics 2012;438(1-2):176-83.
2012: Takuya Suzuki; Eiichi Yamamoto; Hiroshi Kiwada; Kenji Hyodo; Masako Ichihara; Tatsuhiro Ishida; Hiroshi Ishihara; Hiroshi Kikuchi
Accelerated blood clearance of PEGylated liposomes containing doxorubicin upon repeated administration to dogs.
International journal of pharmaceutics 2012;436(1-2):636-43.
2012: Amr Abu Lila; Amr Selim Abu Lila; Tatsuhiro Ishida; Haruna Matsumoto; Hiroyuki Nakamura; Hiroshi Kiwada
Tumor-type-dependent vascular permeability constitutes a potential impediment to the therapeutic efficacy of liposomal oxaliplatin.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2012;81(3):524-31.
2012: Jose Mario Barichello; Tatsuhiro Ishida; Hiroshi Kikuchi; Shinji Kizuki; Luiz Alberto Lira Soares; Tatsuaki Tagami; Hiroshi Kiwada
Agitation during lipoplex formation harmonizes the interaction of siRNA to cationic liposomes.
International journal of pharmaceutics 2012;430(1-2):359-65.
2012: Amr S Abu Lila; Amr Abu Lila; Amr Selim Abu Lila; Tatsuhiro Ishida; Tomoko Okada; Hiroshi Kiwada
Combination therapy with metronomic S-1 dosing and oxaliplatin-containing PEG-coated cationic liposomes in a murine colorectal tumor model: synergy or antagonism?
International journal of pharmaceutics 2012;426(1-2):263-70.
2012: Taro Shimizu; Yasuo Yoshioka; Masako Ichihara; Tatsuhiro Ishida; Shinsaku Nakagawa; Hiroshi Kiwada
Intravenous administration of polyethylene glycol-coated (PEGylated) proteins and PEGylated adenovirus elicits an anti-PEG immunoglobulin M response.
Biological & pharmaceutical bulletin 2012;35(8):1336-42.
2011: Amr Selim Abu Lila; Mariko Matsunaga; Amr Abu Lila; Yusuke Doi; Tatsuhiro Ishida; Hiroshi Kiwada
A double-modulation strategy in cancer treatment with a chemotherapeutic agent and siRNA.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(11):2040-7.
2011: Atsushi Saito; Hiroaki Shimizu; Yusuke Doi; Miki Fujimura; Takashi Inoue; Tatsuhiro Ishida; Hiroshi Kiwada; Teiji Tominaga
Immunoliposomal drug-delivery system targeting lectin-like oxidized low-density lipoprotein receptor-1 for carotid plaque lesions in rats.
Journal of neurosurgery 2011;115(4):720-7.
2011: Jose Mario Barichello; Shinji Kizuki; Tatsuaki Tagami; Tomohiro Asai; Tatsuhiro Ishida; Hiroshi Kikuchi; Naoto Oku; Hiroshi Kiwada
Agitation during lipoplex formation improves the gene knockdown effect of siRNA.
International journal of pharmaceutics 2011;410(1-2):153-60.
2011: Tatsuaki Tagami; Yumi Uehara; Naoto Moriyoshi; Tatsuhiro Ishida; Hiroshi Kiwada
Anti-PEG IgM production by siRNA encapsulated in a PEGylated lipid nanocarrier is dependent on the sequence of the siRNA.
Journal of controlled release : official journal of the Controlled Release Society 2011;151(2):149-54.
2010: Yusuke Doi; Tomoko Okada; Haruna Matsumoto; Masako Ichihara; Tatsuhiro Ishida; Hiroshi Kiwada
Combination therapy of metronomic S-1 dosing with oxaliplatin-containing polyethylene glycol-coated liposome improves antitumor activity in a murine colorectal tumor model.
Cancer science 2010;101(11):2470-5.
2010: Tsutomu Ishihara; Taishi Maeda; Haruka Sakamoto; Naoko Takasaki; Masao Shigyo; Tatsuhiro Ishida; Hiroshi Kiwada; Yutaka Mizushima; Tohru Mizushima
Evasion of the accelerated blood clearance phenomenon by coating of nanoparticles with various hydrophilic polymers.
Biomacromolecules 2010;11(10):2700-6.
2010: Amr Abu Lila; Amr Selim Abu Lila; Hiroshi Kiwada
Targeting anticancer drugs to tumor vasculature using cationic liposomes.
Pharmaceutical research 2010;27(7):1171-83.
2010: Hiroyuki Koide; Tomohiro Asai; Kentaro Hatanaka; Shuji Akai; Takayuki Ishii; Eriya Kenjo; Tatsuhiro Ishida; Hiroshi Kiwada; Hideo Tsukada; Naoto Oku
T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes.
International journal of pharmaceutics 2010;392(1-2):218-23.
2010: Amr Abu Lila; Amr Selim Abu Lila; Kazuya Nakamura; Tatsuhiro Ishida; Hiroshi Kiwada
Sequential administration with oxaliplatin-containing PEG-coated cationic liposomes promotes a significant delivery of subsequent dose into murine solid tumor.
Journal of controlled release : official journal of the Controlled Release Society 2010;142(2):167-73.
2010: Tatsuaki Tagami; Kazuya Nakamura; Taro Shimizu; Naoshi Yamazaki; Tatsuhiro Ishida; Hiroshi Kiwada
CpG motifs in pDNA-sequences increase anti-PEG IgM production induced by PEG-coated pDNA-lipoplexes.
Journal of controlled release : official journal of the Controlled Release Society 2010;142(2):160-6.
2010: Yusuke Eto; Yasuo Yoshioka; Tatsuhiro Ishida; Xinglei Yao; Tomohiro Morishige; Shogo Narimatsu; Hiroyuki Mizuguchi; Yohei Mukai; Naoki Okada; Hiroshi Kiwada; Shinsaku Nakagawa
Optimized PEGylated adenovirus vector reduces the anti-vector humoral immune response against adenovirus and induces a therapeutic effect against metastatic lung cancer.
Biological & pharmaceutical bulletin 2010;33(9):1540-4.
2010: Hiroyuki Yamazaki; Masateru Miyake; Naoki Kamada; Toru Nishibayashi; Tadashi Mukai; Masaaki Odomi; Tatsuhiro Ishida; Hiroshi Kiwada
Co-administration of tacrolimus suppresses pharmacokinetic modulation of multiple subcutaneously administered human interferon-alpha in Beagle dogs.
Drug metabolism and pharmacokinetics 2010;25(2):149-54.
2010: José Mario Barichello; Tatsuhiro Ishida; Hiroshi Kiwada
Complexation of siRNA and pDNA with cationic liposomes: the important aspects in lipoplex preparation.
Methods in molecular biology (Clifton, N.J.) 2010;605():461-72.
2009: Hiroyuki Koide; Tomohiro Asai; Kentaro Hatanaka; Kosuke Shimizu; Masayuki Yokoyama; Tatsuhiro Ishida; Hiroshi Kiwada; Naoto Oku
[Elucidation of accelerated blood clearance phenomenon caused by repeat injection of PEGylated nanocarriers].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2009;129(12):1445-51.
2009: Amr Abu Lila; Amr Selim Abu Lila; Hiroshi Kiwada
Recent advances in tumor vasculature targeting using liposomal drug delivery systems.
Expert opinion on drug delivery 2009;6(12):1297-309.
2009: Tsutomu Ishihara; Miho Takeda; Haruka Sakamoto; Ayumi Kimoto; Chisa Kobayashi; Naoko Takasaki; Kanae Yuki; Ken-ichiro Tanaka; Mitsuko Takenaga; Rie Igarashi; Taishi Maeda; Naoki Yamakawa; Yoshinari Okamoto; Masami Otsuka; Tatsuhiro Ishida; Hiroshi Kiwada; Yutaka Mizushima; Tohru Mizushima
Accelerated blood clearance phenomenon upon repeated injection of PEG-modified PLA-nanoparticles.
Pharmaceutical research 2009;26(10):2270-9.
2009: Tatsuaki Tagami; Kazuya Nakamura; Taro Shimizu; Tatsuhiro Ishida; Hiroshi Kiwada
Effect of siRNA in PEG-coated siRNA-lipoplex on anti-PEG IgM production.
Journal of controlled release : official journal of the Controlled Release Society 2009;137(3):234-40.
2009: Hiroyuki Yamazaki; Masateru Miyake; Toru Nishibayashi; Tadashi Mukai; Masaaki Odomi; Tatsuhiro Ishida; Hiroshi Kiwada
Effect of co-administration of tacrolimus on the pharmacokinetics of multiple subcutaneous administered interferon-alpha in rats.
Pharmaceutical research 2009;26(8):1832-7.
2009: Amr Abu Lila; Shinji Kizuki; Amr Selim Abu Lila; Takuya Suzuki; Tatsuhiro Ishida; Hiroshi Kiwada
Oxaliplatin encapsulated in PEG-coated cationic liposomes induces significant tumor growth suppression via a dual-targeting approach in a murine solid tumor model.
Journal of controlled release : official journal of the Controlled Release Society 2009;137(1):8-14.
2009: Tatsuhiro Ishida; Emi Shiraga; Hiroshi Kiwada
Synergistic antitumor activity of metronomic dosing of cyclophosphamide in combination with doxorubicin-containing PEGylated liposomes in a murine solid tumor model.
Journal of controlled release : official journal of the Controlled Release Society 2009;134(3):194-200.
2009: Yoshimasa Isakari; Shinji Sogo; Tatsuhiro Ishida; Takuma Kawakami; Toshihide Ono; Takao Taki; Hiroshi Kiwada
Gene expression analysis during platelet-like particle production in phorbol myristate acetate-treated MEG-01 cells.
Biological & pharmaceutical bulletin 2009;32(3):354-8.
2009: Amr Abu Lila; Takuya Suzuki; Amr Selim Abu Lila; Tatsuhiro Ishida; Hiroshi Kiwada
Oxaliplatin targeting to angiogenic vessels by PEGylated cationic liposomes suppresses the angiogenesis in a dorsal air sac mouse model.
Journal of controlled release : official journal of the Controlled Release Society 2009;134(1):18-25.
2008: Tatsuaki Tagami; Kiyomi Hirose; Jose Mario Barichello; Tatsuhiro Ishida; Hiroshi Kiwada
Global gene expression profiling in cultured cells is strongly influenced by treatment with siRNA-cationic liposome complexes.
Pharmaceutical research 2008;25(11):2497-504.
2008: Hiroyuki Koide; Tomohiro Asai; Kentaro Hatanaka; Takeo Urakami; Takayuki Ishii; Eriya Kenjo; Masamichi Nishihara; Masayuki Yokoyama; Tatsuhiro Ishida; Hiroshi Kiwada; Naoto Oku
Particle size-dependent triggering of accelerated blood clearance phenomenon.
International journal of pharmaceutics 2008;362(1-2):197-200.
2008: Jose Mario Barichello; Noriko Yamakawa; Masatoshi Kisyuku; Hiroshi Handa; Taiki Shibata; Tatsuhiro Ishida; Hiroshi Kiwada
Combined effect of liposomalization and addition of glycerol on the transdermal delivery of isosorbide 5-nitrate in rat skin.
International journal of pharmaceutics 2008;357(1-2):199-205.
2008: Tatsuhiro Ishida; Hiroshi Kiwada
Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes.
International journal of pharmaceutics 2008;354(1-2):56-62.
2008: Tomohiro Asai; Yuko Suzuki; Saori Matsushita; Sei Yonezawa; Junichi Yokota; Yasufumi Katanasaka; Tatsuhiro Ishida; Takehisa Dewa; Hiroshi Kiwada; Mamoru Nango; Naoto Oku
Disappearance of the angiogenic potential of endothelial cells caused by Argonaute2 knockdown.
Biochemical and biophysical research communications 2008;368(2):243-8.
2008: Emi Shiraga; Jose Mario Barichello; Tatsuhiro Ishida; Hiroshi Kiwada
A metronomic schedule of cyclophosphamide combined with PEGylated liposomal doxorubicin has a highly antitumor effect in an experimental pulmonary metastatic mouse model.
International journal of pharmaceutics 2008;353(1-2):65-73.
2008: Kuniko Matsumura-Takeda; Tatsuhiro Ishida; Shinji Sogo; Yoshimasa Isakari; Takao Taki; Toshiki Sudo; Hiroshi Kiwada
Lactoferrin inhibits platelet production from human megakaryocytes in vitro.
Biological & pharmaceutical bulletin 2008;31(4):569-73.
2008: Tatsuhiro Ishida; Syuntaro Kashima; Hiroshi Kiwada
The contribution of phagocytic activity of liver macrophages to the accelerated blood clearance (ABC) phenomenon of PEGylated liposomes in rats.
Journal of controlled release : official journal of the Controlled Release Society 2008;126(2):162-5.
2008: Tatsuhiro Ishida; Hiroshi Kiwada
[Accelerated blood clearance (ABC) phenomenon induced by administration of PEGylated liposome].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2008;128(2):233-43.
2007: Tatsuhiro Ishida; Xinyu Wang; Taro Shimizu; Kosuke Nawata; Hiroshi Kiwada
PEGylated liposomes elicit an anti-PEG IgM response in a T cell-independent manner.
Journal of controlled release : official journal of the Controlled Release Society 2007;122(3):349-55.
2007: Hiroto Hatakeyama; Hidetaka Akita; Emi Ishida; Koichi Hashimoto; Hideo Kobayashi; Takanori Aoki; Junko Yasuda; Kenichi Obata; Hiroshi Kikuchi; Tatsuhiro Ishida; Hiroshi Kiwada; Hideyoshi Harashima
Tumor targeting of doxorubicin by anti-MT1-MMP antibody-modified PEG liposomes.
International journal of pharmaceutics 2007;342(1-2):194-200.
2007: Yoshimasa Isakari; Yasuo Harada; Dai Ishikawa; Kuniko Matsumura-Takeda; Shinji Sogo; Tatsuhiro Ishida; Takao Taki; Hiroshi Kiwada
Efficient gene expression in megakaryocytic cell line using nucleofection.
International journal of pharmaceutics 2007;338(1-2):157-64.
2007: XinYu Wang; Tatsuhiro Ishida; Hiroshi Kiwada
Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes.
Journal of controlled release : official journal of the Controlled Release Society 2007;119(2):236-44.
2007: Kazutaka Atobe; Tatsuhiro Ishida; Emi Ishida; Kouichi Hashimoto; Hideo Kobayashi; Jyunko Yasuda; Takanori Aoki; Ken-Ichi Obata; Hiroshi Kikuchi; Hidetaka Akita; Tomohiro Asai; Hideyoshi Harashima; Naoto Oku; Hiroshi Kiwada
In vitro efficacy of a sterically stabilized immunoliposomes targeted to membrane type 1 matrix metalloproteinase (MT1-MMP).
Biological & pharmaceutical bulletin 2007;30(5):972-8.
2007: Lap Thi Nguyen; Kazutaka Atobe; Jose Mario Barichello; Tatsuhiro Ishida; Hiroshi Kiwada
Complex formation with plasmid DNA increases the cytotoxicity of cationic liposomes.
Biological & pharmaceutical bulletin 2007;30(4):751-7.
2007: Tatsuaki Tagami; Jose Mario Barichello; Hiroshi Kikuchi; Tatsuhiro Ishida; Hiroshi Kiwada
The gene-silencing effect of siRNA in cationic lipoplexes is enhanced by incorporating pDNA in the complex.
International journal of pharmaceutics 2007;333(1-2):62-9.
2007: Tomotaka Kobayashi; Tatsuhiro Ishida; Yurie Okada; Saori Ise; Hideyoshi Harashima; Hiroshi Kiwada
Effect of transferrin receptor-targeted liposomal doxorubicin in P-glycoprotein-mediated drug resistant tumor cells.
International journal of pharmaceutics 2007;329(1-2):94-102.
2006: Tatsuhiro Ishida; Kazutaka Atobe; XingYu Wang; Hiroshi Kiwada
Accelerated blood clearance of PEGylated liposomes upon repeated injections: effect of doxorubicin-encapsulation and high-dose first injection.
Journal of controlled release : official journal of the Controlled Release Society 2006;115(3):251-8.
2006: Tatsuhiro Ishida; Masako Ichihara; XinYu Wang; Hiroshi Kiwada
Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes.
Journal of controlled release : official journal of the Controlled Release Society 2006;115(3):243-50.
2006: Jose Mario Barichello; Hiroshi Handa; Masatoshi Kisyuku; Taiki Shibata; Tatsuhiro Ishida; Hiroshi Kiwada
Inducing effect of liposomalization on the transdermal delivery of hydrocortisone: creation of a drug supersaturated state.
Journal of controlled release : official journal of the Controlled Release Society 2006;115(1):94-102.
2006: Fuquan Dang; Wenhao Li; Lihua Zhang; Mohammad Jabasini; Tatsuhiro Ishida; Hiroshi Kiwada; Noritada Kaji; Manabu Tokeshi; Yoshinobu Baba
Electrophoretic behavior of plasmid DNA in the presence of various intercalating dyes.
Journal of chromatography. A 2006;1118(2):218-25.
2006: Tatsuhiro Ishida; Masako Ichihara; XinYu Wang; Kenji Yamamoto; Junji Kimura; Eiji Majima; Hiroshi Kiwada
Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes.
Journal of controlled release : official journal of the Controlled Release Society 2006;112(1):15-25.
2006: Tatsuhiro Ishida; Yoshihiro Takanashi; Hiroshi Kiwada
Safe and efficient drug delivery system with liposomes for intrathecal application of an antivasospastic drug, fasudil.
Biological & pharmaceutical bulletin 2006;29(3):397-402.
2006: Tatsuhiro Ishida; Wenhao Li; Zhihui Liu; Hiroshi Kiwada
Stimulatory effect of polyethylene glycol (PEG) on gene expression in mouse liver following hydrodynamics-based transfection.
The journal of gene medicine 2006;8(3):324-34.
2006: Tatsuhiro Ishida; Yurie Okada; Tomotaka Kobayashi; Hiroshi Kiwada
Development of pH-sensitive liposomes that efficiently retain encapsulated doxorubicin (DXR) in blood.
International journal of pharmaceutics 2006;309(1-2):94-100.
2005: Lap Thi Nguyen; Tatsuhiro Ishida; Hiroshi Kiwada
Gene expression in primary cultured mouse hepatocytes with a cationic liposomal vector, TFL-3: comparison with rat hepatocytes.
Biological & pharmaceutical bulletin 2005;28(8):1472-5.
2005: Tatsuhiro Ishida; Masae Harada; Xin Yu Wang; Masako Ichihara; Kenji Irimura; Hiroshi Kiwada
Accelerated blood clearance of PEGylated liposomes following preceding liposome injection: effects of lipid dose and PEG surface-density and chain length of the first-dose liposomes.
Journal of controlled release : official journal of the Controlled Release Society 2005;105(3):305-17.
2005: Xin Yu Wang; Tatsuhiro Ishida; Masako Ichihara; Hiroshi Kiwada
Influence of the physicochemical properties of liposomes on the accelerated blood clearance phenomenon in rats.
Journal of controlled release : official journal of the Controlled Release Society 2005;104(1):91-102.
2005: Wenhao Li; Tatsuhiro Ishida; Yurie Okada; Naoto Oku; Hiroshi Kiwada
Increased gene expression by cationic liposomes (TFL-3) in lung metastases following intravenous injection.
Biological & pharmaceutical bulletin 2005;28(4):701-6.
2004: Wenhao Li; Tatsuhiro Ishida; Rieko Tachibana; Mohamad Radwan Almofti; Xinyu Wang; Hiroshi Kiwada
Cell type-specific gene expression, mediated by TFL-3, a cationic liposomal vector, is controlled by a post-transcription process of delivered plasmid DNA.
International journal of pharmaceutics 2004;276(1-2):67-74.
2004: Tatsuhiro Ishida; Takako Ichikawa; Masako Ichihara; Yasuyuki Sadzuka; Hiroshi Kiwada
Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice.
Journal of controlled release : official journal of the Controlled Release Society 2004;95(3):403-12.
2004: Rieko Tachibana; Naoko Ide; Yasuo Shinohara; Hideyoshi Harashima; C Anthony Hunt; Hiroshi Kiwada
An assessment of relative transcriptional availability from nonviral vectors.
International journal of pharmaceutics 2004;270(1-2):315-21.
2003: Lap Thi Nguyen; Tatsuhiro Ishida; Sachiko Ukitsu; Wen Hao Li; Rieko Tachibana; Hiroshi Kiwada
Culture time-dependent gene expression in isolated primary cultured rat hepatocytes by transfection with the cationic liposomal vector TFL-3.
Biological & pharmaceutical bulletin 2003;26(6):880-5.
2003: Tatsuhiro Ishida; Kaori Masuda; Takako Ichikawa; Masako Ichihara; Kenji Irimura; Hiroshi Kiwada
Accelerated clearance of a second injection of PEGylated liposomes in mice.
International journal of pharmaceutics 2003;255(1-2):167-74.
2003: Mohamad Radwan Almofti; Hideyoshi Harashima; Yasuo Shinohara; Ammar Almofti; Yoshinobu Baba; Hiroshi Kiwada
Cationic liposome-mediated gene delivery: biophysical study and mechanism of internalization.
Archives of biochemistry and biophysics 2003;410(2):246-53.
2003: Tatsuhiro Ishida; Ryuhei Maeda; Masako Ichihara; Kenji Irimura; Hiroshi Kiwada
Accelerated clearance of PEGylated liposomes in rats after repeated injections.
Journal of controlled release : official journal of the Controlled Release Society 2003;88(1):35-42.
2003: Rieko Tachibana; Shiroh Futaki; Hideyoshi Harashima; Hiroshi Kiwada
pH-sensitive liposomes in nuclear targeting of macromolecules.
Methods in enzymology 2003;372():349-61.
2003: Mohamad Radwan Almofti; Hideyoshi Harashima; Yasuo Shinohara; Ammar Almofti; Wenhao Li; Hiroshi Kiwada
Lipoplex size determines lipofection efficiency with or without serum.
Molecular membrane biology 2003;20(1):35-43.
2002: Sayaka Yamamoto; Tatsuhiro Ishida; Akiko Inoue; Junko Mikami; Masahiro Muraguchi; Yasukazu Ohmoto; Hiroshi Kiwada
HEPC-based liposomes trigger cytokine release from peripheral blood cells: effects of liposomal size, dose and lipid composition.
International journal of pharmaceutics 2002;236(1-2):125-33.
2002: Tatsuhiro Ishida; Hideyoshi Harashima; Hiroshi Kiwada
Liposome clearance.
Bioscience reports 2002;22(2):197-224.
2002: Rieko Tachibana; Hideyoshi Harashima; Naoko Ide; Sachiko Ukitsu; Yasuko Ohta; Norio Suzuki; Hiroshi Kikuchi; Yasuo Shinohara; Hiroshi Kiwada
Quantitative analysis of correlation between number of nuclear plasmids and gene expression activity after transfection with cationic liposomes.
Pharmaceutical research 2002;19(4):377-81.
2002: Rieko Tachibana; Hideyoshi Harashima; Tatsuhiro Ishida; Yasuo Shinohara; Mami Hino; Hiroshi Terada; Yoshinobu Baba; Hiroshi Kiwada
Effect of cationic liposomes in an in vitro transcription and translation system.
Biological & pharmaceutical bulletin 2002;25(4):529-31.
2002: Tatsuhiro Ishida; Yoshihiro Takanashi; Hisako Doi; Isao Yamamoto; Hiroshi Kiwada
Encapsulation of an antivasospastic drug, fasudil, into liposomes, and in vitro stability of the fasudil-loaded liposomes.
International journal of pharmaceutics 2002;232(1-2):59-67.
2002: Ryotaro Azuma; Masahito Komuro; Yasuro Kawaguchi; Kazuho Okudaira; Masahiro Hayashi; Hiroshi Kiwada
Comparative analysis of in vitro and in vivo pharmacokinetic parameters related to individual variability of GTS-21 in canine.
Drug metabolism and pharmacokinetics 2002;17(1):75-82.
2002: Hideyoshi Harashima; Tatsuhiro Ishida; Hiroyuki Kamiya; Hiroshi Kiwada
Pharmacokinetics of targeting with liposomes.
Critical reviews in therapeutic drug carrier systems 2002;19(3):235-75.
2002: Tatsuhiro Ishida; Ryuhei Maeda; Masako Ichihara; Yasuko Mukai; Yoko Motoki; Yoshie Manabe; Kenji Irimura; Hiroshi Kiwada
The accelerated clearance on repeated injection of pegylated liposomes in rats: laboratory and histopathological study.
Cellular & molecular biology letters 2002;7(2):286.
2001: Tatsuhiro Ishida; Hideyoshi Harashima; Hiroshi Kiwada
Interactions of liposomes with cells in vitro and in vivo: opsonins and receptors.
Current drug metabolism 2001;2(4):397-409.
2001: Rieko Tachibana; Hideyoshi Harashima; Yasuo Shinohara; Hiroshi Kiwada
Quantitative studies on the nuclear transport of plasmid DNA and gene expression employing nonviral vectors.
Advanced drug delivery reviews 2001;52(3):219-26.
2001: Ryotaro Azuma; T Hirota; H Manabe; Masahito Komuro; Hiroshi Kiwada
First-pass of GTS-21 on canine gut wall and liver determined by portal-systemic concentration difference.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2001;14(2):159-65.
2001: Tatsuhiro Ishida; K Yasukawa; H Kojima; Hideyoshi Harashima; Hiroshi Kiwada
Effect of cholesterol content in activation of the classical versus the alternative pathway of rat complement system induced by hydrogenated egg phosphatidylcholine-based liposomes.
International journal of pharmaceutics 2001;224(1-2):69-79.
2001: TM Huong; Tatsuhiro Ishida; Hideyoshi Harashima; Hiroshi Kiwada
Species difference in correlation between in vivo/in vitro liposome-complement interactions.
Biological & pharmaceutical bulletin 2001;24(4):439-41.
2001: Hideyoshi Harashima; Y Shinohara; Hiroshi Kiwada
Intracellular control of gene trafficking using liposomes as drug carriers.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2001;13(1):85-9.
2001: TM Huong; Tatsuhiro Ishida; Hideyoshi Harashima; Hiroshi Kiwada
The complement system enhances the clearance of phosphatidylserine (PS)-liposomes in rat and guinea pig.
International journal of pharmaceutics 2001;215(1-2):197-205.
2000: Tatsuhiro Ishida; H Kojima; Hideyoshi Harashima; Hiroshi Kiwada
Biodistribution of liposomes and C3 fragments associated with liposomes: evaluation of their relationship.
International journal of pharmaceutics 2000;205(1-2):183-93.
1999: Hideyoshi Harashima; S Iida; Yoshihito Urakami; M Tsuchihashi; Hiroshi Kiwada
Optimization of antitumor effect of liposomally encapsulated doxorubicin based on simulations by pharmacokinetic/pharmacodynamic modeling.
Journal of controlled release : official journal of the Controlled Release Society 1999;61(1-2):93-106.
1999: M Tsuchihashi; Hideyoshi Harashima; Hiroshi Kiwada
Development of a pharmacokinetic/pharmacodynamic (PK/PD)-simulation system for doxorubicin in long circulating liposomes in mice using peritoneal P388.
Journal of controlled release : official journal of the Controlled Release Society 1999;61(1-2):9-19.
1999: TM Huong; Hideyoshi Harashima; Hiroshi Kiwada
In vivo studies on the role of complement in the clearance of liposomes in rats and guinea pigs.
Biological & pharmaceutical bulletin 1999;22(5):515-20.
1999: Masamichi Kuwajima; Hideyoshi Harashima; M Hayashi; S Ise; Masako Sei; K m Lu; Hiroshi Kiwada; Y Sugiyama; K Shima
Pharmacokinetic analysis of the cardioprotective effect of 3-(2,2, 2-trimethylhydrazinium) propionate in mice: inhibition of carnitine transport in kidney.
The Journal of pharmacology and experimental therapeutics 1999;289(1):93-102.
1998: Rieko Tachibana; Hideyoshi Harashima; Masayuki Shono; M Azumano; M Niwa; Shiroh Futaki; Hiroshi Kiwada
Intracellular regulation of macromolecules using pH-sensitive liposomes and nuclear localization signal: qualitative and quantitative evaluation of intracellular trafficking.
Biochemical and biophysical research communications 1998;251(2):538-44.
1998: TM Huong; Hideyoshi Harashima; Hiroshi Kiwada
Complement dependent and independent liposome uptake by peritoneal macrophages: cholesterol content dependency.
Biological & pharmaceutical bulletin 1998;21(9):969-73.
1998: M Yamada; Hideyoshi Harashima; Hiroshi Kiwada
Kinetic analysis of the interaction between liposomes and the complement system in rat serum: re-evaluation of size-dependency.
Biological & pharmaceutical bulletin 1998;21(9):964-8.
1998: S Liu; Tatsuhiro Ishida; Hiroshi Kiwada
Characterization of bovine serum factor triggering the lysis of liposomes via complement activation.
Biological & pharmaceutical bulletin 1998;21(4):390-7.
1997: S Liu; Tatsuhiro Ishida; Hiroshi Kiwada
Effect of serum components from different species on destabilizing hydrogenated phosphatidylcholine-based liposomes.
Biological & pharmaceutical bulletin 1997;20(8):874-80.
1996: Hideyoshi Harashima; TM Huong; Tatsuhiro Ishida; Y Manabe; H Matsuo; Hiroshi Kiwada
Synergistic effect between size and cholesterol content in the enhanced hepatic uptake clearance of liposomes through complement activation in rats.
Pharmaceutical research 1996;13(11):1704-9.
1996: K Yachi; Hideyoshi Harashima; H Kikuchi; R Sudo; H Yamauchi; K Ebihara; H Matsuo; K Funato; Hiroshi Kiwada
Biopharmaceutical evaluation of the liposomes prepared by rehydration of freeze-dried empty liposomes (FDELs) with an aqueous solution of a drug.
Biopharmaceutics & drug disposition 1996;17(7):589-605.
1996: Hideyoshi Harashima; S Komatsu; S Kojima; C Yanagi; Y Morioka; M Naito; Hiroshi Kiwada
Species difference in the disposition of liposomes among mice, rats, and rabbits: allometric relationship and species dependent hepatic uptake mechanism.
Pharmaceutical research 1996;13(7):1049-54.
1996: A J Ferdous; T Ishida; M Shinohara; Hideyoshi Harashima; Hiroshi Kiwada
Size-dependent release of carboxyfluorescein from cetylmannoside-modified liposomes in human plasma.
Biopharmaceutics & drug disposition 1996;17(2):145-54.
1995: H Matsuo; C Yamashita; K Akiyama; Hiroshi Kiwada
Effect of cetylmannoside modification on the alternative complement pathway activation by liposomes in rat serum.
Biological & pharmaceutical bulletin 1995;18(4):581-5.
1995: Hideyoshi Harashima; N Hirai; Hiroshi Kiwada
Kinetic modelling of liposome degradation in peritoneal macrophages.
Biopharmaceutics & drug disposition 1995;16(2):113-23.
1995: Hideyoshi Harashima; T Hiraiwa; Y Ochi; Hiroshi Kiwada
Size dependent liposome degradation in blood: in vivo/in vitro correlation by kinetic modeling.
Journal of drug targeting 1995;3(4):253-61.
1994: Y Matsuki; R Bandou; Hiroshi Kiwada; H Maeda; T Goromaru
Effects of ascorbic acid on iproniazid-induced hepatitis in phenobarbital-treated rats.
Biological & pharmaceutical bulletin 1994;17(8):1078-82.
1994: S Osaka; H Tsuji; Hiroshi Kiwada
Uptake of liposomes surface-modified with glycyrrhizin by primary cultured rat hepatocytes.
Biological & pharmaceutical bulletin 1994;17(7):940-3.
1994: Hideyoshi Harashima; Hiroshi Kiwada; J Kajita; S Kobayashi
Effects of benidipine hydrochloride (Coniel), a new calcium antagonist, on the cardiac output, regional blood flow and vascular resistance in conscious, spontaneously hypertensive rats.
Biopharmaceutics & drug disposition 1994;15(5):431-8.
1994: Hideyoshi Harashima; Y Ochi; Hiroshi Kiwada
Kinetic modelling of liposome degradation in serum: effect of size and concentration of liposomes in vitro.
Biopharmaceutics & drug disposition 1994;15(3):217-25.
1994: Hideyoshi Harashima; K Sakata; K Funato; Hiroshi Kiwada
Enhanced hepatic uptake of liposomes through complement activation depending on the size of liposomes.
Pharmaceutical research 1994;11(3):402-6.
1994: K Funato; C Yamashita; J Kamada; S Tominaga; Hiroshi Kiwada
Plasma factor triggering alternative complement pathway activation by liposomes.
Pharmaceutical research 1994;11(3):372-6.
1994: H Matsuo; K Funato; Hideyoshi Harashima; Hiroshi Kiwada
The complement- but not mannose receptor-mediated phagocytosis is involved in the hepatic uptake of cetylmannoside-modified liposomes in situ.
Journal of drug targeting 1994;2(2):141-6.
1993: Hideyoshi Harashima; Y Midori; S Ohshima; K Yachi; H Kikuchi; Hiroshi Kiwada
Kinetic analysis of tissue distribution of doxorubicin incorporated in liposomes in rats (II).
Biopharmaceutics & drug disposition 1993;14(7):595-608.
1993: Hideyoshi Harashima; C Yamane; Y Kume; Hiroshi Kiwada
Kinetic analysis of AUC-dependent saturable clearance of liposomes: mathematical description of AUC dependency.
Journal of pharmacokinetics and biopharmaceutics 1993;21(3):299-308.
1993: Hideyoshi Harashima; Y Kume; C Yamane; Hiroshi Kiwada
Kinetic modeling of liposome degradation in blood circulation.
Biopharmaceutics & drug disposition 1993;14(3):265-70.
1993: Hideyoshi Harashima; K Sakata; Hiroshi Kiwada
Distinction between the depletion of opsonins and the saturation of uptake in the dose-dependent hepatic uptake of liposomes.
Pharmaceutical research 1993;10(4):606-10.
1992: Y Matsuki; Y Hongu; Y Noda; Hiroshi Kiwada; H Sakurai; T Goromaru
[Effects of ascorbic acid on the metabolic fate and the free radical formation of iproniazid].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1992;112(12):926-33.
1992: Hideyoshi Harashima; Y Ohnishi; Hiroshi Kiwada
In vivo evaluation of the effect of the size and opsonization on the hepatic extraction of liposomes in rats: an application of Oldendorf method.
Biopharmaceutics & drug disposition 1992;13(7):549-53.
1992: Hideyoshi Harashima; Y Kume; C Yamane; Hiroshi Kiwada
Non-Michaelis-Menten type hepatic uptake of liposomes in the rat.
The Journal of pharmacy and pharmacology 1992;44(9):707-12.
1992: Hideyoshi Harashima; S Ohshima; Y Midori; K Yachi; H Kikuchi; Hiroshi Kiwada
Kinetic analysis of tissue distribution of doxorubicin incorporated in liposomes in rats: I.
Biopharmaceutics & drug disposition 1992;13(3):155-70.
1992: K Funato; R Yoda; Hiroshi Kiwada
Contribution of complement system on destabilization of liposomes composed of hydrogenated egg phosphatidylcholine in rat fresh plasma.
Biochimica et biophysica acta 1992;1103(2):198-204.
1991: Y Matsuki; M Akazawa; K Tsuchiya; H Sakurai; Hiroshi Kiwada; T Goromaru
[Effects of ascorbic acid on the free radical formations of isoniazid and its metabolites].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1991;111(10):600-5.
1991: C Yamashita; Saburo Sone; T Ogura; Hiroshi Kiwada
Potential value of cetylmannoside-modified liposomes as carriers of macrophage activators to human blood monocytes.
Japanese journal of cancer research : Gann 1991;82(5):569-76.
1991: H Tsuji; S Osaka; Hiroshi Kiwada
Targeting of liposomes surface-modified with glycyrrhizin to the liver. I. Preparation and biological disposition.
Chemical & pharmaceutical bulletin 1991;39(4):1004-8.
1991: Y Kume; F Maeda; Hideyoshi Harashima; Hiroshi Kiwada
Saturable, non-Michaelis-Menten uptake of liposomes by the reticuloendothelial system.
The Journal of pharmacy and pharmacology 1991;43(3):162-6.
1991: Y Matsuki; Y Katakuse; H Matsuura; Hiroshi Kiwada; T Goromaru
Effects of glucose and ascorbic acid on absorption and first pass metabolism of isoniazid in rats.
Chemical & pharmaceutical bulletin 1991;39(2):445-8.
1989: K Tahara; M Hayashi; S Awazu; Y Kato; Hiroshi Kiwada
Effect of serum on dose- and temperature-dependent hepatic uptake of multilamellar vesicles (MLV).
Journal of pharmacobio-dynamics 1989;12(10):596-601.