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Hiroshi Kiyono

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Hase Koji; Kawano Kazuya; Nochi Tomonori; Pontes Gemilson Soares; Fukuda Shinji; Ebisawa Masashi; Kadokura Kazunori; Tobe Toru; Fujimura Yumiko; Kawano Sayaka; Yabashi Atsuko; Waguri Satoshi; Nakato Gaku; Kimura Shunsuke; Murakami Takaya; Iimura Mitsutoshi; Hamura Kimiyo; Fukuoka Shin-Ichi; Lowe Anson W; Itoh Kikuji; Kiyono Hiroshi; Ohno Hiroshi
Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response.
Sato Ayuko; Kiyono Hiroshi
[The mucosal immune system: new strategy for the control of allergic diseases]
Nochi Tomonori; Yuki Yoshikazu; Katakai Yuko; Shibata Hiroaki; Tokuhara Daisuke; Mejima Mio; Kurokawa Shiho; Takahashi Yuko; Nakanishi Ushio; Ono Fumiko; Mimuro Hitomi; Sasakawa Chihiro; Takaiwa Fumio; Terao Keiji; Kiyono Hiroshi
A rice-based oral cholera vaccine induces macaque-specific systemic neutralizing antibodies but does not influence pre-existing intestinal immunity.

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All Publications

2009: Hase Koji; Kawano Kazuya; Nochi Tomonori; Pontes Gemilson Soares; Fukuda Shinji; Ebisawa Masashi; Kadokura Kazunori; Tobe Toru; Fujimura Yumiko; Kawano Sayaka; Yabashi Atsuko; Waguri Satoshi; Nakato Gaku; Kimura Shunsuke; Murakami Takaya; Iimura Mitsutoshi; Hamura Kimiyo; Fukuoka Shin-Ichi; Lowe Anson W; Itoh Kikuji; Kiyono Hiroshi; Ohno Hiroshi
Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response.
Nature 2009;462(7270):226-30.
2009: Sato Ayuko; Kiyono Hiroshi
[The mucosal immune system: new strategy for the control of allergic diseases]
Nippon rinsho. Japanese journal of clinical medicine 2009;67(11):2194-9.
2009: Nochi Tomonori; Yuki Yoshikazu; Katakai Yuko; Shibata Hiroaki; Tokuhara Daisuke; Mejima Mio; Kurokawa Shiho; Takahashi Yuko; Nakanishi Ushio; Ono Fumiko; Mimuro Hitomi; Sasakawa Chihiro; Takaiwa Fumio; Terao Keiji; Kiyono Hiroshi
A rice-based oral cholera vaccine induces macaque-specific systemic neutralizing antibodies but does not influence pre-existing intestinal immunity.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(10):6538-44.
2009: Nagatake Takahiro; Fukuyama Satoshi; Kim Dong-Young; Goda Kaoru; Igarashi Osamu; Sato Shintaro; Nochi Tomonori; Sagara Hiroshi; Yokota Yoshifumi; Jetten Anton M; Kaisho Tsuneyasu; Akira Shizuo; Mimuro Hitomi; Sasakawa Chihiro; Fukui Yoshinori; Fujihashi Kohtaro; Akiyama Taishin; Inoue Jun-ichiro; Penninger Josef M; Kunisawa Jun; Kiyono Hiroshi
Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity.
The Journal of experimental medicine 2009;206(11):2351-64.
2009: Yuki Yoshikazu; Tokuhara Daisuke; Nochi Tomonori; Yasuda Hiroshi; Mejima Mio; Kurokawa Shiho; Takahashi Yuko; Kataoka Nobuhiro; Nakanishi Ushio; Hagiwara Yukari; Fujihashi Kohtaro; Takaiwa Fumio; Kiyono Hiroshi
Oral MucoRice expressing double-mutant cholera toxin A and B subunits induces toxin-specific neutralising immunity.
Vaccine 2009;27(43):5982-8.
2009: Yuki Yoshikazu; Kiyono Hiroshi
Mucosal vaccines: novel advances in technology and delivery.
Expert review of vaccines 2009;8(8):1083-97.
2009: Fujihashi Kohtaro; Kiyono Hiroshi
Mucosal immunosenescence: new developments and vaccines to control infectious diseases.
Trends in immunology 2009;30(7):334-43.
2009: Kim Donghyun; Kim Seon Hee; Park Eun-Jin; Kim Jiyoung; Cho Sang-Heon; Kagawa Junko; Arai Naoko; Jun Kunisawa; Kiyono Hiroshi; Kim Sunyoung
Suppression of allergic diarrhea in murine ovalbumin-induced allergic diarrhea model by PG102, a water-soluble extract prepared from Actinidia arguta.
International archives of allergy and immunology 2009;150(2):164-71.
2008: Mestecky Jiri; Nguyen Huan; Czerkinsky Cecil; Kiyono Hiroshi
Oral immunization: an update.
Current opinion in gastroenterology 2008;24(6):713-9.
2008: Kunisawa Jun; Nochi Tomonori; Kiyono Hiroshi
Immunological commonalities and distinctions between airway and digestive immunity.
Trends in immunology 2008;29(11):505-13.
2008: Yuki Yoshikazu; Kiyono Hiroshi
[MucoRice: development of rice-based oral vaccine]
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 2008;31(5):369-74.
2008: Caipang Christopher Marlowe A; Verjan Noel; Ooi Ei Lin; Kondo Hidehiro; Hirono Ikuo; Aoki Takashi; Kiyono Hiroshi; Yuki Yoshikazu
Enhanced survival of shrimp, Penaeus (Marsupenaeus) japonicus from white spot syndrome disease after oral administration of recombinant VP28 expressed in Brevibacillus brevis.
Fish & shellfish immunology 2008;25(3):315-20.
2008: Uematsu Satoshi; Fujimoto Kosuke; Jang Myoung Ho; Yang Bo-Gie; Jung Yun-Jae; Nishiyama Mika; Sato Shintaro; Tsujimura Tohru; Yamamoto Masafumi; Yokota Yoshifumi; Kiyono Hiroshi; Miyasaka Masayuki; Ishii Ken J; Akira Shizuo
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.
Nature immunology 2008;9(7):769-76.
2008: Verjan Noel; Ooi Ei Lin; Nochi Tomonori; Kondo Hidehiro; Hirono Ikuo; Aoki Takashi; Kiyono Hiroshi; Yuki Yoshikazu
A soluble nonglycosylated recombinant infectious hematopoietic necrosis virus (IHNV) G-protein induces IFNs in rainbow trout (Oncorhynchus mykiss).
Fish & shellfish immunology 2008;25(1-2):170-80.
2008: Kobayashi Toshihiko; Takahashi Koichiro; Nagai Yoshinori; Shibata Takuma; Otani Masako; Izui Shozo; Akira Shizuo; Gotoh Yoshiyuki; Kiyono Hiroshi; Miyake Kensuke
Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice.
International immunology 2008;20(7):881-91.
2008: Terahara Kazutaka; Yoshida Masato; Igarashi Osamu; Nochi Tomonori; Pontes Gemilson Soares; Hase Koji; Ohno Hiroshi; Kurokawa Shiho; Mejima Mio; Takayama Naoko; Yuki Yoshikazu; Lowe Anson W; Kiyono Hiroshi
Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(12):7840-6.
2008: Momoi Fumiki; Hashizume Tomomi; Kurita-Ochiai Tomoko; Yuki Yoshikazu; Kiyono Hiroshi; Yamamoto Masafumi
Nasal vaccination with the 40-kilodalton outer membrane protein of Porphyromonas gingivalis and a nontoxic chimeric enterotoxin adjuvant induces long-term protective immunity with reduced levels of immunoglobulin E antibodies.
Infection and immunity 2008;76(6):2777-84.
2008: Ooi Ei Lin; Verjan Noel; Hirono Ikuo; Nochi Tomonori; Kondo Hidehiro; Aoki Takashi; Kiyono Hiroshi; Yuki Yoshikazu
Biological characterisation of a recombinant Atlantic salmon type I interferon synthesized in Escherichia coli.
Fish & shellfish immunology 2008;24(5):506-13.
2008: Kunisawa Jun; Gohda Masashi; Kurashima Yosuke; Ishikawa Izumi; Higuchi Morio; Kiyono Hiroshi
Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.
Blood 2008;111(9):4646-52.
2008: Gohda Masashi; Kunisawa Jun; Miura Fumi; Kagiyama Yuki; Kurashima Yosuke; Higuchi Morio; Ishikawa Izumi; Ogahara Ikuko; Kiyono Hiroshi
Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(8):5335-43.
2008: Chang Sun-Young; Cha Hye-Ran; Igarashi Osamu; Rennert Paul D; Kissenpfennig Adrien; Malissen Bernard; Nanno Masanobu; Kiyono Hiroshi; Kweon Mi-Na
Cutting edge: Langerin+ dendritic cells in the mesenteric lymph node set the stage for skin and gut immune system cross-talk.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):4361-5.
2008: Hashizume Tomomi; Togawa Atsushi; Nochi Tomonori; Igarashi Osamu; Kweon Mi-Na; Kiyono Hiroshi; Yamamoto Masafumi
Peyer's patches are required for intestinal immunoglobulin A responses to Salmonella spp.
Infection and immunity 2008;76(3):927-34.
2008: Kurashima Yosuke; Kunisawa Jun; Kiyono Hiroshi
[Applicable strategies for the mucosal immune system in the regulation of allergic diseases]
Arerugi = [Allergy] 2008;57(2):87-94.
2008: Ooi Ei Lin; Verjan Noel; Haraguchi Ikumi; Oshima Takeo; Kondo Hidehiro; Hirono Ikuo; Aoki Takashi; Kiyono Hiroshi; Yuki Yoshikazu
Innate immunomodulation with recombinant interferon-alpha enhances resistance of rainbow trout (Oncorhynchus mykiss) to infectious hematopoietic necrosis virus.
Developmental and comparative immunology 2008;32(10):1211-20.
2007: Nochi Tomonori; Yuki Yoshikazu; Matsumura Akiko; Mejima Mio; Terahara Kazutaka; Kim Dong-Young; Fukuyama Satoshi; Iwatsuki-Horimoto Kiyoko; Kawaoka Yoshihiro; Kohda Tomoko; Kozaki Shunji; Igarashi Osamu; Kiyono Hiroshi
A novel M cell-specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses.
The Journal of experimental medicine 2007;204(12):2789-96.
2007: Takamura Kaoru; Fukuyama Satoshi; Nagatake Takahiro; Kim Dong-Young; Kawamura Aya; Kawauchi Hideyuki; Kiyono Hiroshi
Regulatory role of lymphoid chemokine CCL19 and CCL21 in the control of allergic rhinitis.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):5897-906.
2007: Kunisawa Jun; Kurashima Yosuke; Higuchi Morio; Gohda Masashi; Ishikawa Izumi; Ogahara Ikuko; Kim Namju; Shimizu Miki; Kiyono Hiroshi
Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium.
The Journal of experimental medicine 2007;204(10):2335-48.
2007: Yuki Yoshikazu; Nochi Tomonori; Kiyono Hiroshi
Progress towards an AIDS mucosal vaccine: an overview.
Tuberculosis (Edinburgh, Scotland) 2007;87 Suppl 1():S35-44.
2007: Kurashima Yosuke; Kunisawa Jun; Higuchi Morio; Gohda Masashi; Ishikawa Izumi; Takayama Naoko; Shimizu Miki; Kiyono Hiroshi
Sphingosine 1-phosphate-mediated trafficking of pathogenic Th2 and mast cells for the control of food allergy.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(3):1577-85.
2007: Ohka Seii; Igarashi Hiroko; Nagata Noriyo; Sakai Mai; Koike Satoshi; Nochi Tomonori; Kiyono Hiroshi; Nomoto Akio
Establishment of a poliovirus oral infection system in human poliovirus receptor-expressing transgenic mice that are deficient in alpha/beta interferon receptor.
Journal of virology 2007;81(15):7902-12.
2007: Nochi Tomonori; Takagi Hidenori; Yuki Yoshikazu; Yang Lijun; Masumura Takehiro; Mejima Mio; Nakanishi Ushio; Matsumura Akiko; Uozumi Akihiro; Hiroi Takachika; Morita Shigeto; Tanaka Kunisuke; Takaiwa Fumio; Kiyono Hiroshi
Rice-based mucosal vaccine as a global strategy for cold-chain- and needle-free vaccination.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(26):10986-91.
2007: Nagai Shigenori; Mimuro Hitomi; Yamada Taketo; Baba Yukiko; Moro Kazuyo; Nochi Tomonori; Kiyono Hiroshi; Suzuki Toshihiko; Sasakawa Chihiro; Koyasu Shigeo
Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(21):8971-6.
2007: Takayama Naoko; Igarashi Osamu; Kweon Mi-Na; Kiyono Hiroshi
Regulatory role of Peyer's patches for the inhibition of OVA-induced allergic diarrhea.
Clinical immunology (Orlando, Fla.) 2007;123(2):199-208.
2007: Tamagawa Hiroshi; Hiroi Takachika; Mizushima Tsunekazu; Ito Toshinori; Matsuda Hikaru; Kiyono Hiroshi
Therapeutic effects of roxithromycin in interleukin-10-deficient colitis.
Inflammatory bowel diseases 2007;13(5):547-56.
2007: Kunisawa Jun; Kurashima Yosuke; Gohda Masashi; Higuchi Morio; Ishikawa Izumi; Miura Fumi; Ogahara Ikuko; Kiyono Hiroshi
Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production.
Blood 2007;109(9):3749-56.
2007: Fukuyama Satoshi; Kiyono Hiroshi
Neuroregulator RET initiates Peyer's-patch tissue genesis.
Immunity 2007;26(4):393-5.
2007: Makita Shin; Kanai Takanori; Nemoto Yasuhiro; Totsuka Teruji; Okamoto Ryuichi; Tsuchiya Kiichiro; Yamamoto Masafumi; Kiyono Hiroshi; Watanabe Mamoru
Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):4937-46.
2007: McGhee Jerry R; Kunisawa Jun; Kiyono Hiroshi
Gut lymphocyte migration: we are halfway 'home'.
Trends in immunology 2007;28(4):150-3.
2007: Kim Namju; Kunisawa Jun; Kweon Mi-Na; Eog Ji Geun; Kiyono Hiroshi
Oral feeding of Bifidobacterium bifidum (BGN4) prevents CD4(+) CD45RB(high) T cell-mediated inflammatory bowel disease by inhibition of disordered T cell activation.
Clinical immunology (Orlando, Fla.) 2007;123(1):30-9.
2007: Kunisawa Jun; Takahashi Ichiro; Kiyono Hiroshi
Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine.
Immunological reviews 2007;215():136-53.
2007: Kunisawa Jun; Gohda Masashi; Kiyono Hiroshi
[Uniqueness of the mucosal immune system for the development of prospective mucosal vaccine]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2007;127(2):319-26.
2006: Maddaloni Massimo; Staats Herman F; Mierzejewska Dagmara; Hoyt Teri; Robinson Amy; Callis Gayle; Kozaki Shunji; Kiyono Hiroshi; McGhee Jerry R; Fujihashi Kohtaro; Pascual David W
Mucosal vaccine targeting improves onset of mucosal and systemic immunity to botulinum neurotoxin A.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5524-32.
2006: Fukuyama Satoshi; Nagatake Takahiro; Kim Dong-Young; Takamura Kaoru; Park Eun Jeong; Kaisho Tsuneyasu; Tanaka Norimitsu; Kurono Yuichi; Kiyono Hiroshi
Cutting edge: Uniqueness of lymphoid chemokine requirement for the initiation and maturation of nasopharynx-associated lymphoid tissue organogenesis.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(7):4276-80.
2006: Hagiwara Yukari; Kawamura Yuki I; Kataoka Kosuke; Rahima Bibi; Jackson Raymond J; Komase Katsuhiro; Dohi Taeko; Boyaka Prosper N; Takeda Yoshifumi; Kiyono Hiroshi; McGhee Jerry R; Fujihashi Kohtaro
A second generation of double mutant cholera toxin adjuvants: enhanced immunity without intracellular trafficking.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):3045-54.
2006: Duverger Alexandra; Jackson Raymond J; van Ginkel Frederick W; Fischer Romy; Tafaro Angela; Leppla Stephen H; Fujihashi Kohtaro; Kiyono Hiroshi; McGhee Jerry R; Boyaka Prosper N
Bacillus anthracis edema toxin acts as an adjuvant for mucosal immune responses to nasally administered vaccine antigens.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1776-83.
2006: Jang Myoung Ho; Sougawa Nagako; Tanaka Toshiyuki; Hirata Takako; Hiroi Takachika; Tohya Kazuo; Guo Zijin; Umemoto Eiji; Ebisuno Yukihiko; Yang Bo-Gie; Seoh Ju-Young; Lipp Martin; Kiyono Hiroshi; Miyasaka Masayuki
CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(2):803-10.
2006: Nochi Tomonori; Kiyono Hiroshi
Innate immunity in the mucosal immune system.
Current pharmaceutical design 2006;12(32):4203-13.
2005: Yuki Yoshikazu; Hara-Yakoyama Chisato; Guadiz Abigail A E; Udaka Shigezo; Kiyono Hiroshi; Chatterjee Subhendra
Production of a recombinant cholera toxin B subunit-insulin B chain peptide hybrid protein by Brevibacillus choshinensis expression system as a nasal vaccine against autoimmune diabetes.
Biotechnology and bioengineering 2005;92(7):803-9.
2005: Takagi Hidenori; Hiroi Takachika; Yang Lijun; Tada Yoshifumi; Yuki Yoshikazu; Takamura Kaoru; Ishimitsu Ryotaro; Kawauchi Hideyuki; Kiyono Hiroshi; Takaiwa Fumio
A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th2-mediated IgE responses.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(48):17525-30.
2005: Kunisawa Jun; Fukuyama Satoshi; Kiyono Hiroshi
Mucosa-associated lymphoid tissues in the aerodigestive tract: their shared and divergent traits and their importance to the orchestration of the mucosal immune system.
Current molecular medicine 2005;5(6):557-72.
2005: Ohmura Mari; Yamamoto Masafumi; Tomiyama-Miyaji Chikako; Yuki Yoshikazu; Takeda Yoshifumi; Kiyono Hiroshi
Nontoxic Shiga toxin derivatives from Escherichia coli possess adjuvant activity for the augmentation of antigen-specific immune responses via dendritic cell activation.
Infection and immunity 2005;73(7):4088-97.
2005: Kunisawa J; Kiyono H
A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense.
Cellular and molecular life sciences : CMLS 2005;62(12):1308-21.
2005: Hino Ayako; Fukuyama Satoshi; Kataoka Kosuke; Kweon Mi-Na; Fujihashi Kohtaro; Kiyono Hiroshi
Nasal IL-12p70 DNA prevents and treats intestinal allergic diarrhea.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):7423-32.
2005: Yamamoto Masafumi; Kiyono Hiroshi
[Host defence mechanisms offered by the mucosal immune system]
Nippon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 4():447-53.
2005: Nochi Tomonori; Kiyono Hiroshi
[Mucosal immunology]
Nippon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 4():14-9.
2005: Kai Yasuyuki; Takahashi Ichiro; Ishikawa Hiromichi; Hiroi Takachika; Mizushima Tsunekazu; Matsuda Chu; Kishi Daisuke; Hamada Hiromasa; Tamagawa Hiroshi; Ito Toshinori; Yoshizaki Kazuyuki; Kishimoto Tadamitsu; Matsuda Hikaru; Kiyono Hiroshi
Colitis in mice lacking the common cytokine receptor gamma chain is mediated by IL-6-producing CD4+ T cells.
Gastroenterology 2005;128(4):922-34.
2005: Kweon Mi-Na; Yamamoto Masafumi; Rennert Paul D; Park Eun Jeong; Lee Ah-Young; Chang Sun-Young; Hiroi Takachika; Nanno Masanobu; Kiyono Hiroshi
Prenatal blockage of lymphotoxin beta receptor and TNF receptor p55 signaling cascade resulted in the acceleration of tissue genesis for isolated lymphoid follicles in the large intestine.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):4365-72.
2005: Kobayashi Ryoki; Kohda Tomoko; Kataoka Kosuke; Ihara Hideshi; Kozaki Shunji; Pascual David W; Staats Herman F; Kiyono Hiroshi; McGhee Jerry R; Fujihashi Kohtaro
A novel neurotoxoid vaccine prevents mucosal botulism.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):2190-5.
2005: Nonaka Satoshi; Naito Tomoaki; Chen Hao; Yamamoto Masafumi; Moro Kazuyo; Kiyono Hiroshi; Hamada Hiromasa; Ishikawa Hiromichi
Intestinal gamma delta T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):1906-12.
2004: Yoshino Naoto; Lü Fabien X-S; Fujihashi Kohtaro; Hagiwara Yukari; Kataoka Kosuke; Lu Ding; Hirst Linda; Honda Mitsuo; van Ginkel Frederik W; Takeda Yoshifumi; Miller Christopher J; Kiyono Hiroshi; McGhee Jerry R
A novel adjuvant for mucosal immunity to HIV-1 gp120 in nonhuman primates.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):6850-7.
2004: Nochi Tomonori; Yuki Yoshikazu; Terahara Kazutaka; Hino Ayako; Kunisawa Jun; Kweon Mi-Na; Yamaguchi Takahiro; Kiyono Hiroshi
Biological role of Ep-CAM in the physical interaction between epithelial cells and lymphocytes in intestinal epithelium.
Clinical immunology (Orlando, Fla.) 2004;113(3):326-39.
2004: Kiyono Hiroshi; Fukuyama Satoshi
NALT- versus Peyer's-patch-mediated mucosal immunity.
Nature reviews. Immunology 2004;4(9):699-710.
2004: Ueta Mayumi; Nochi Tomonori; Jang Myoung-Ho; Park Eun Jeong; Igarashi Osamu; Hino Ayako; Kawasaki Satoshi; Shikina Takashi; Hiroi Takachika; Kinoshita Shigeru; Kiyono Hiroshi
Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):3337-47.
2004: Ohmura-Hoshino Mari; Yamamoto Masafumi; Yuki Yoshikazu; Takeda Yoshifumi; Kiyono Hiroshi
Non-toxic Stx derivatives from Escherichia coli possess adjuvant activity for mucosal immunity.
Vaccine 2004;22(27-28):3751-61.
2004: Yamamoto Masafumi; Kweon Mi-Na; Rennert Paul D; Hiroi Takachika; Fujihashi Kohtaro; McGhee Jerry R; Kiyono Hiroshi
Role of gut-associated lymphoreticular tissues in antigen-specific intestinal IgA immunity.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):762-9.
2004: Mizushima Tsunekazu; Ito Toshinori; Kishi Daisuke; Kai Yasuyuki; Tamagawa Hiroshi; Nezu Riichiro; Kiyono Hiroshi; Matsuda Hikaru
Therapeutic effects of a new lymphocyte homing reagent FTY720 in interleukin-10 gene-deficient mice with colitis.
Inflammatory bowel diseases 2004;10(3):182-92.
2004: Shikina Takashi; Hiroi Takachika; Iwatani Kohichi; Jang Myoung Ho; Fukuyama Satoshi; Tamura Manabu; Kubo Takeshi; Ishikawa Hiromichi; Kiyono Hiroshi
IgA class switch occurs in the organized nasopharynx- and gut-associated lymphoid tissue, but not in the diffuse lamina propria of airways and gut.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6259-64.
2004: Jang Myoung Ho; Kweon Mi-Na; Iwatani Koichi; Yamamoto Masafumi; Terahara Kazutaka; Sasakawa Chihiro; Suzuki Toshihiko; Nochi Tomonori; Yokota Yoshifumi; Rennert Paul D; Hiroi Takachika; Tamagawa Hiroshi; Iijima Hideki; Kunisawa Jun; Yuki Yoshikazu; Kiyono Hiroshi
Intestinal villous M cells: an antigen entry site in the mucosal epithelium.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):6110-5.
2004: Hino Ayako; Kweon Mi-Na; Fujihashi Kohtaro; McGhee Jerry R; Kiyono Hiroshi
Pathological role of large intestinal IL-12p40 for the induction of Th2-type allergic diarrhea.
The American journal of pathology 2004;164(4):1327-35.
2003: Park Eun Jeong; Takahashi Ichiro; Ikeda Junko; Kawahara Kazuko; Okamoto Tetsuji; Kweon Mi-Na; Fukuyama Satoshi; Groh Veronika; Spies Thomas; Obata Yuichi; Miyazaki Jun-Ichi; Kiyono Hiroshi
Clonal expansion of double-positive intraepithelial lymphocytes by MHC class I-related chain A expressed in mouse small intestinal epithelium.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4131-9.
2003: Yuki Yoshikazu; Kiyono Hiroshi
New generation of mucosal adjuvants for the induction of protective immunity.
Reviews in medical virology 2003;13(5):293-310.
2003: Tamagawa Hiroshi; Takahashi Ichiro; Furuse Mikio; Yoshitake-Kitano Yuka; Tsukita Shoichiro; Ito Toshinori; Matsuda Hikaru; Kiyono Hiroshi
Characteristics of claudin expression in follicle-associated epithelium of Peyer's patches: preferential localization of claudin-4 at the apex of the dome region.
Laboratory investigation; a journal of technical methods and pathology 2003;83(7):1045-53.
2003: Kobayashi Masaya; Kweon Mi-Na; Kuwata Hirotaka; Schreiber Robert D; Kiyono Hiroshi; Takeda Kiyoshi; Akira Shizuo
Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice.
The Journal of clinical investigation 2003;111(9):1297-308.
2003: Jang Myoung Ho; Kweon Mi Na; Hiroi Takachika; Yamamoto Masafumi; Takahashi Ichiro; Kiyono Hiroshi
Induction of cytotoxic T lymphocyte responses by cholera toxin-treated bone marrow-derived dendritic cells.
Vaccine 2003;21(15):1613-9.
2003: Hagiwara Yukari; McGhee Jerry R; Fujihashi Keiko; Kobayashi Ryoki; Yoshino Naoto; Kataoka Kosuke; Etani Yuri; Kweon Mi-Na; Tamura Shinichi; Kurata Takeshi; Takeda Yoshifumi; Kiyono Hiroshi; Fujihashi Kohtaro
Protective mucosal immunity in aging is associated with functional CD4+ T cells in nasopharyngeal-associated lymphoreticular tissue.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):1754-62.
2003: Kweon Mi-Na; Kiyono Hiroshi
Eosinophilic gastroenteritis: a problem of the mucosal immune system?
Current allergy and asthma reports 2003;3(1):79-85.
2003: Okuda Yoshiko; Takahashi Ichiro; Kim Jin-Kyung; Ohta Noriyuki; Iwatani Kouichi; Iijima Hideki; Kai Yasuyuki; Tamagawa Hiroshi; Hiroi Takachika; Kweon Mi-Na; Kawano Sunao; Takeda Kiyoshi; Akira Sizuo; Sasaki Yutaka; Hori Masatsugu; Kiyono Hiroshi
Development of colitis in signal transducers and activators of transcription 6-deficient T-cell receptor alpha-deficient mice: a potential role of signal transducers and activators of transcription 6-independent interleukin-4 signaling for the generation of Th2-biased pathological CD4+ betabetaT cells.
The American journal of pathology 2003;162(1):263-71.
2003: Sakaue Gaku; Hiroi Takachika; Nakagawa Yoko; Someya Kenji; Iwatani Kohich; Sawa Yoshiki; Takahashi Hidemi; Honda Mitsuo; Kunisawa Jun; Kiyono Hiroshi
HIV mucosal vaccine: nasal immunization with gp160-encapsulated hemagglutinating virus of Japan-liposome induces antigen-specific CTLs and neutralizing antibody responses.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):495-502.
2003: Boyaka Prosper N; Ohmura Mari; Fujihashi Kohtaro; Koga Toshiya; Yamamoto Masafumi; Kweon Mi-Na; Takeda Yoshifumi; Jackson Raymond J; Kiyono Hiroshi; Yuki Yoshikazu; McGhee Jerry R
Chimeras of labile toxin one and cholera toxin retain mucosal adjuvanticity and direct Th cell subsets via their B subunit.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):454-62.
2002: Kawahara Mamoru; Matsuo Kazuhiro; Nakasone Tadashi; Hiroi Takachika; Kiyono Hiroshi; Matsumoto Sohkichi; Yamada Takeshi; Yamamoto Naoki; Honda Mitsuo
Combined intrarectal/intradermal inoculation of recombinant Mycobacterium bovis bacillus Calmette-Guérin (BCG) induces enhanced immune responses against the inserted HIV-1 V3 antigen.
Vaccine 2002;21(3-4):158-66.
2002: Kinoshita Naotoshi; Hiroi Takachika; Ohta Noriyuki; Fukuyama Satoshi; Park Eun Jeong; Kiyono Hiroshi
Autocrine IL-15 mediates intestinal epithelial cell death via the activation of neighboring intraepithelial NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(11):6187-92.
2002: Kweon Mi-Na; Yamamoto Masafumi; Watanabe Fumiko; Tamura Shinichi; Van Ginkel Frederik W; Miyauchi Akira; Takagi Hiroaki; Takeda Yoshifumi; Hamabata Takashi; Fujihashi Kohtaro; McGhee Jerry R; Kiyono Hiroshi
A nontoxic chimeric enterotoxin adjuvant induces protective immunity in both mucosal and systemic compartments with reduced IgE antibodies.
The Journal of infectious diseases 2002;186(9):1261-9.
2002: Watanabe Izumi; Hagiwara Yukari; Kadowaki Shin-etsu; Yoshikawa Tomoki; Komase Katsuhiro; Aizawa Chikara; Kiyono Hiroshi; Takeda Yoshifumi; McGhee Jerry R; Chiba Joe; Sata Tetsutaro; Kurata Takeshi; Tamura Shin-ichi
Characterization of protective immune responses induced by nasal influenza vaccine containing mutant cholera toxin as a safe adjuvant (CT112K).
Vaccine 2002;20(29-30):3443-55.
2002: Yanagita Manabu; Shimabukuro Yoshio; Nozaki Takenori; Yoshimura Naoko; Watanabe Junko; Koide Hiroko; Terakura Mami; Saho Teruyuki; Takedachi Masahide; Jang Myoung-Ho; Kiyono Hiroshi; Murakami Shinya
IL-15 up-regulates iNOS expression and NO production by gingival epithelial cells.
Biochemical and biophysical research communications 2002;297(2):329-34.
2002: Kunisawa Jun; Takahashi Ichiro; Okudaira Akiko; Hiroi Takachika; Katayama Kazufumi; Ariyama Teruko; Tsutsumi Yasuo; Nakagawa Shinsaku; Kiyono Hiroshi; Mayumi Tadanori
Lack of antigen-specific immune responses in anti-IL-7 receptor alpha chain antibody-treated Peyer's patch-null mice following intestinal immunization with microencapsulated antigen.
European journal of immunology 2002;32(8):2347-55.
2002: Fukuyama Satoshi; Hiroi Takachika; Yokota Yoshifumi; Rennert Paul D; Yanagita Manabu; Kinoshita Naotoshi; Terawaki Seigo; Shikina Takashi; Yamamoto Masafumi; Kurono Yuichi; Kiyono Hiroshi
Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells.
Immunity 2002;17(1):31-40.
2002: Suenobu Noriko; Kweon Mi-Na; Kiyono Hiroshi
Nasal vaccination induces the ability to eliminate Candida colonization without influencing the pre-existing antigen-specific IgE Abs: a possibility for the control of Candida-related atopic dermatitis.
Vaccine 2002;20(23-24):2972-80.
2002: Ohta Noriyuki; Hiroi Takachika; Kweon Mi-Na; Kinoshita Naotoshi; Jang Myoung Ho; Mashimo Tadashi; Miyazaki Jun-Ichi; Kiyono Hiroshi
IL-15-dependent activation-induced cell death-resistant Th1 type CD8 alpha beta+NK1.1+ T cells for the development of small intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):460-8.
2002: Takahashi Ichiro; Matsuda Jennifer; Gapin Laurent; DeWinter Hilde; Kai Yasuyuki; Tamagawa Hiroshi; Kronenberg Mitchell; Kiyono Hiroshi
Colitis-related public T cells are selected in the colonic lamina propria of IL-10-deficient mice.
Clinical immunology (Orlando, Fla.) 2002;102(3):237-48.
2002: Kweon M-N; Takahashi I; Yamamoto M; Jang M H; Suenobu N; Kiyono H
Development of antigen induced colitis in SCID mice reconstituted with spleen derived memory type CD4(+) CD45RB(+) T cells.
Gut 2002;50(3):299-306.
2002: Kweon Mi-Na; Kiyono Hiroshi
CD40L in autoimmunity and mucosally induced tolerance.
The Journal of clinical investigation 2002;109(2):171-3.
2002: Hamada Hiromasa; Hiroi Takachika; Nishiyama Yasuhiro; Takahashi Hidemi; Masunaga Yohei; Hachimura Satoshi; Kaminogawa Shuichi; Takahashi-Iwanaga Hiromi; Iwanaga Toshihiko; Kiyono Hiroshi; Yamamoto Hiroshi; Ishikawa Hiromichi
Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):57-64.
2001: Hiroi T; Goto H; Someya K; Yanagita M; Honda M; Yamanaka N; Kiyono H
HIV mucosal vaccine: nasal immunization with rBCG-V3J1 induces a long term V3J1 peptide-specific neutralizing immunity in Th1- and Th2-deficient conditions.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5862-7.
2001: Fujihashi K; Kato H; van Ginkel F W; Koga T; Boyaka P N; Jackson R J; Kato R; Hagiwara Y; Etani Y; Goma I; Fujihashi K; Kiyono H; McGhee J R
A revisit of mucosal IgA immunity and oral tolerance.
Acta odontologica Scandinavica 2001;59(5):301-8.
2001: Kim J K; Takahashi I; Kai Y; Kiyono H
Influence of enterotoxin on mucosal intranet: selective inhibition of extrathymic T cell development in intestinal intraepithelial lymphocytes by oral exposure to heat-labile toxin.
European journal of immunology 2001;31(10):2960-9.
2001: Yura M; Takahashi I; Terawaki S; Hiroi T; Kweon M N; Yuki Y; Kiyono H
Nasal administration of cholera toxin (CT) suppresses clinical signs of experimental autoimmune encephalomyelitis (EAE).
Vaccine 2001;20(1-2):134-9.
2001: Dohi T; Rennert P D; Fujihashi K; Kiyono H; Shirai Y; Kawamura Y I; Browning J L; McGhee J R
Elimination of colonic patches with lymphotoxin beta receptor-Ig prevents Th2 cell-type colitis.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2781-90.
2001: Yura M; Takahashi I; Serada M; Koshio T; Nakagami K; Yuki Y; Kiyono H
Role of MOG-stimulated Th1 type "light up" (GFP+) CD4+ T cells for the development of experimental autoimmune encephalomyelitis (EAE).
Journal of autoimmunity 2001;17(1):17-25.
2001: Kunisawa J; Nakanishi T; Takahashi I; Okudaira A; Tsutsumi Y; Katayama K; Nakagawa S; Kiyono H; Mayumi T
Sendai virus fusion protein mediates simultaneous induction of MHC class I/II-dependent mucosal and systemic immune responses via the nasopharyngeal-associated lymphoreticular tissue immune system.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1406-12.
2001: Sakaue G; Shimaoka M; Fukuoka T; Hiroi T; Inoue T; Hashimoto N; Sakaguchi T; Sawa Y; Morishita R; Kiyono H; Noguchi K; Mashimo T
NF-kappa B decoy suppresses cytokine expression and thermal hyperalgesia in a rat neuropathic pain model.
Neuroreport 2001;12(10):2079-84.
2001: Kim J K; Takahashi I; Okuda Y; Itakura M; McGhee J R; Kiyono H
T cell receptor dynamism of mucosal and systemic CD4+ T cells in the course of an immune response to Escherichia coli heat-labile enterotoxin.
The Journal of infectious diseases 2001;184(1):43-51.
2001: Yuki Y; Byun Y; Fujita M; Izutani W; Suzuki T; Udaka S; Fujihashi K; McGhee J R; Kiyono H
Production of a recombinant hybrid molecule of cholera toxin-B-subunit and proteolipid-protein-peptide for the treatment of experimental encephalomyelitis.
Biotechnology and bioengineering 2001;74(1):62-9.
2001: Kiyono H; Kweon M N; Hiroi T; Takahashi I
The mucosal immune system: from specialized immune defense to inflammation and allergy.
Acta odontologica Scandinavica 2001;59(3):145-53.
2001: Shimizu M; Minakuchi K; Tsuda A; Hiroi T; Tanaka N; Koga J; Kiyono H
Role of stem cell factor and c-kit signaling in regulation of fetal intestinal epithelial cell adhesion to fibronectin.
Experimental cell research 2001;266(2):311-22.
2001: Ohta N; Shimaoka M; Imanaka H; Nishimura M; Taenaka N; Kiyono H; Yoshiya I
Glucocorticoid suppresses neutrophil activation in ventilator-induced lung injury.
Critical care medicine 2001;29(5):1012-6.
2001: Iijima H; Takahashi I; Kiyono H
Mucosal immune network in the gut for the control of infectious diseases.
Reviews in medical virology 2001;11(2):117-33.
2001: Yamamoto M; McGhee J R; Hagiwara Y; Otake S; Kiyono H
Genetically manipulated bacterial toxin as a new generation mucosal adjuvant.
Scandinavian journal of immunology 2001;53(3):211-7.
2001: Fujihashi K; Dohi T; Rennert P D; Yamamoto M; Koga T; Kiyono H; McGhee J R
Peyer's patches are required for oral tolerance to proteins.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3310-5.
2001: Saito M; Otake S; Ohmura M; Hirasawa M; Takada K; Mega J; Takahashi I; Kiyono H; McGhee J R; Takeda Y; Yamamoto M
Protective immunity to Streptococcus mutans induced by nasal vaccination with surface protein antigen and mutant cholera toxin adjuvant.
The Journal of infectious diseases 2001;183(5):823-6.
2001: Byun Y; Ohmura M; Fujihashi K; Yamamoto S; McGhee J R; Udaka S; Kiyono H; Takeda Y; Kohsaka T; Yuki Y
Nasal immunization with E. coli verotoxin 1 (VT1)-B subunit and a nontoxic mutant of cholera toxin elicits serum neutralizing antibodies.
Vaccine 2001;19(15-16):2061-70.
2001: Kiyono H
Mucosal immune system: close encounter in the uncharted world of immunology.
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde 2001;215 Suppl 1():22-32.
2000: Kunisawa J; Sakaue G; Kiyono H
[NALT immune system for the development of AIDS mucosal vaccine]
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 2000;23(6):579-81.
2000: Boyaka P N; Wright P F; Marinaro M; Kiyono H; Johnson J E; Gonzales R A; Ikizler M R; Werkhaven J A; Jackson R J; Fujihashi K; Di Fabio S; Staats H F; McGhee J R
Human nasopharyngeal-associated lymphoreticular tissues. Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils.
The American journal of pathology 2000;157(6):2023-35.
2000: Kishi D; Takahashi I; Kai Y; Tamagawa H; Iijima H; Obunai S; Nezu R; Ito T; Matsuda H; Kiyono H
Alteration of V beta usage and cytokine production of CD4+ TCR beta beta homodimer T cells by elimination of Bacteroides vulgatus prevents colitis in TCR alpha-chain-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5891-9.
2000: Koga T; McGhee J R; Kato H; Kato R; Kiyono H; Fujihashi K
Evidence for early aging in the mucosal immune system.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):5352-9.
2000: Hiroi T; Yanagita M; Ohta N; Sakaue G; Kiyono H
IL-15 and IL-15 receptor selectively regulate differentiation of common mucosal immune system-independent B-1 cells for IgA responses.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(8):4329-37.
2000: Kunisawa J; Okudaira A; Tsutusmi Y; Takahashi I; Nakanishi T; Kiyono H; Mayumi T
Characterization of mucoadhesive microspheres for the induction of mucosal and systemic immune responses.
Vaccine 2000;19(4-5):589-94.
2000: Dohi T; Fujihashi K; Kiyono H; Elson C O; McGhee J R
Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis.
Gastroenterology 2000;119(3):724-33.
2000: Kweon M N; Yamamoto M; Kajiki M; Takahashi I; Kiyono H
Systemically derived large intestinal CD4(+) Th2 cells play a central role in STAT6-mediated allergic diarrhea.
The Journal of clinical investigation 2000;106(2):199-206.
2000: Yamamoto M; Kiyono H; Kweon M N; Yamamoto S; Fujihashi K; Kurazono H; Imaoka K; Bluethmann H; Takahashi I; Takeda Y; Azuma M; McGhee J R
Enterotoxin adjuvants have direct effects on T cells and antigen-presenting cells that result in either interleukin-4-dependent or -independent immune responses.
The Journal of infectious diseases 2000;182(1):180-90.
2000: Yamamoto M; Rennert P; McGhee J R; Kweon M N; Yamamoto S; Dohi T; Otake S; Bluethmann H; Fujihashi K; Kiyono H
Alternate mucosal immune system: organized Peyer's patches are not required for IgA responses in the gastrointestinal tract.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(10):5184-91.
2000: Saitoh-Inagawa W; Hiroi T; Yanagita M; Iijima H; Uchio E; Ohno S; Aoki K; Kiyono H
Unique characteristics of lacrimal glands as a part of mucosal immune network: high frequency of IgA-committed B-1 cells and NK1.1+ alphabeta T cells.
Investigative ophthalmology & visual science 2000;41(1):138-44.
1999: Fujihashi K; Dohi T; Kweon M N; McGhee J R; Koga T; Cooper M D; Tonegawa S; Kiyono H
gammadelta T cells regulate mucosally induced tolerance in a dose-dependent fashion.
International immunology 1999;11(12):1907-16.
1999: Pascual D W; Hone D M; Hall S; van Ginkel F W; Yamamoto M; Walters N; Fujihashi K; Powell R J; Wu S; Vancott J L; Kiyono H; McGhee J R
Expression of recombinant enterotoxigenic Escherichia coli colonization factor antigen I by Salmonella typhimurium elicits a biphasic T helper cell response.
Infection and immunity 1999;67(12):6249-56.
1999: Tori M; Ito T; Yumiba T; Okawa A; Maeda A; Sawai T; Kiyomoto T; Akamaru Y; Miyasaka M; Kiyono H; Matsuda H; Nozawa M; Shirakura R
Proliferation of donor-derived NKR-P1+TCR alpha beta + (NKT) cells in the nonrecurrent spontaneous diabetic BB rats transplanted with pancreaticoduodenal grafts of Wistar-Furth donors.
Transplantation proceedings 1999;31(7):2741-2.
1999: Iijima H; Takahashi I; Kishi D; Kim J K; Kawano S; Hori M; Kiyono H
Alteration of interleukin 4 production results in the inhibition of T helper type 2 cell-dominated inflammatory bowel disease in T cell receptor alpha chain-deficient mice.
The Journal of experimental medicine 1999;190(5):607-15.
1999: Tori M; Ito T; Yumiba T; Ohkawa A; Maeda A; Sawai T; Kiyomoto T; Akamaru Y; Miyasaka M; Kiyono H; Matsuda H; Nozawa M; Shirakura R
IL-4 production in IDDM-nonrecurrent pancreas-transplanted BB rats with donor-derived NKR-P1+TCR alpha beta + (NKT) cells, but not in IDDM-recurrent BB rats.
Transplantation proceedings 1999;31(5):1940-1.
1999: van Ginkel F W; Wahl S M; Kearney J F; Kweon M N; Fujihashi K; Burrows P D; Kiyono H; McGhee J R
Partial IgA-deficiency with increased Th2-type cytokines in TGF-beta 1 knockout mice.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):1951-7.
1999: Yamamoto M; Kiyono H; Yamamoto S; Batanero E; Kweon M N; Otake S; Azuma M; Takeda Y; McGhee J R
Direct effects on antigen-presenting cells and T lymphocytes explain the adjuvanticity of a nontoxic cholera toxin mutant.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7015-21.
1999: McGhee J R; Kiyono H; Kubota M; Kawabata S; Miller C J; Lehner T; Imaoka K; Fujihashi K
Mucosal Th1- versus Th2-type responses for antibody- or cell-mediated immunity to simian immunodeficiency virus in rhesus macaques.
The Journal of infectious diseases 1999;179 Suppl 3():S480-4.
1999: Boyaka P N; Marinaro M; Vancott J L; Takahashi I; Fujihashi K; Yamamoto M; van Ginkel F W; Jackson R J; Kiyono H; McGhee J R
Strategies for mucosal vaccine development.
The American journal of tropical medicine and hygiene 1999;60(4 Suppl):35-45.
1999: Dohi T; Fujihashi K; Rennert P D; Iwatani K; Kiyono H; McGhee J R
Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses.
The Journal of experimental medicine 1999;189(8):1169-80.
1999: Yamamoto M; Kiyono H
Immunoregulatory functions of mucosal gammadelta T cells.
Microbes and infection / Institut Pasteur 1999;1(3):241-6.
1999: Yanagita M; Hiroi T; Kitagaki N; Hamada S; Ito H O; Shimauchi H; Murakami S; Okada H; Kiyono H
Nasopharyngeal-associated lymphoreticular tissue (NALT) immunity: fimbriae-specific Th1 and Th2 cell-regulated IgA responses for the inhibition of bacterial attachment to epithelial cells and subsequent inflammatory cytokine production.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3559-65.
1999: Kweon M N; Fujihashi K; Wakatsuki Y; Koga T; Yamamoto M; McGhee J R; Kiyono H
Mucosally induced systemic T cell unresponsiveness to ovalbumin requires CD40 ligand-CD40 interactions.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):1904-9.
1999: Takahashi I; Iijima H; Katashima R; Itakura M; Kiyono H
Clonal expansion of CD4+ TCRbetabeta+ T cells in TCR alpha-chain- deficient mice by gut-derived antigens.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1843-50.
1999: Nguyen H H; Moldoveanu Z; Novak M J; van Ginkel F W; Ban E; Kiyono H; McGhee J R; Mestecky J
Heterosubtypic immunity to lethal influenza A virus infection is associated with virus-specific CD8(+) cytotoxic T lymphocyte responses induced in mucosa-associated tissues.
Virology 1999;254(1):50-60.
1999: Sugimoto M; Shimaoka M; Taenaka N; Kiyono H; Yoshiya I
Lymphocyte activation is attenuated by stellate ganglion block.
Regional anesthesia and pain medicine 1999;24(1):30-5.
1999: Hiroi T; Yanagita M; Iijima H; Iwatani K; Yoshida T; Takatsu K; Kiyono H
Deficiency of IL-5 receptor alpha-chain selectively influences the development of the common mucosal immune system independent IgA-producing B-1 cell in mucosa-associated tissues.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):821-8.
1999: Boyaka P N; Marinaro M; Jackson R J; Menon S; Kiyono H; Jirillo E; McGhee J R
IL-12 is an effective adjuvant for induction of mucosal immunity.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):122-8.
1999: Marinaro M; Boyaka P N; Jackson R J; Finkelman F D; Kiyono H; Jirillo E; McGhee J R
Use of intranasal IL-12 to target predominantly Th1 responses to nasal and Th2 responses to oral vaccines given with cholera toxin.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):114-21.
1999: Takahashi I; Lijima H; Kishi D; Kiyono H
Oligoclonal Th2-biased betabeta T cells induce murine inflammatory bowel disease.
Immunologic research 1999;20(3):237-42.
1999: Tori M; Ito T; Yumiba T; Maeda A; Sawai T; Miyasaka M; Kiyono H; Matsuda H; Nozawa M; Shirakura R
Significant role of intragraft lymphoid tissues in preventing insulin-dependent diabetes mellitus recurrence in whole pancreaticoduodenal transplantation.
Microsurgery 1999;19(7):338-43.
1998: Kobayashi T; Yamamoto M; Hiroi T; McGhee J; Takeshita Y; Kiyono H
Arginine enhances induction of T helper 1 and T helper 2 cytokine synthesis by Peyer's patch alpha beta T cells and antigen-specific mucosal immune response.
Bioscience, biotechnology, and biochemistry 1998;62(12):2334-40.
1998: Shimaoka M; Hosotsubo K; Sugimoto M; Sakaue G; Taenaka N; Yoshiya I; Kiyono H
The influence of surgical stress on T cells: enhancement of early phase lymphocyte activation.
Anesthesia and analgesia 1998;87(6):1431-5.
1998: Imaoka K; Miller C J; Kubota M; McChesney M B; Lohman B; Yamamoto M; Fujihashi K; Someya K; Honda M; McGhee J R; Kiyono H
Nasal immunization of nonhuman primates with simian immunodeficiency virus p55gag and cholera toxin adjuvant induces Th1/Th2 help for virus-specific immune responses in reproductive tissues.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):5952-8.
1998: VanCott J L; Chatfield S N; Roberts M; Hone D M; Hohmann E L; Pascual D W; Yamamoto M; Kiyono H; McGhee J R
Regulation of host immune responses by modification of Salmonella virulence genes.
Nature medicine 1998;4(11):1247-52.
1998: Iijima H; Takahashi I; Hiroi T; Shimaoka M; Kawano S; Nagano K; Hori M; Kiyono H
Orally administered cholera toxin prevents murine intestinal T cells from staphylococcal enterotoxin B-induced anergy.
Gastroenterology 1998;115(5):1197-204.
1998: Harris P R; Ernst P B; Kawabata S; Kiyono H; Graham M F; Smith P D
Recombinant Helicobacter pylori urease activates primary mucosal macrophages.
The Journal of infectious diseases 1998;178(5):1516-20.
1998: Marinaro M; Boyaka P N; Kiyono H; McGhee J R
Novel approaches for the induction of T helper 1 (Th1)- or Th2-type mucosal and parenteral immune responses.
Expert opinion on investigational drugs 1998;7(10):1657-66.
1998: Hiroi T; Iwatani K; Iijima H; Kodama S; Yanagita M; Kiyono H
Nasal immune system: distinctive Th0 and Th1/Th2 type environments in murine nasal-associated lymphoid tissues and nasal passage, respectively.
European journal of immunology 1998;28(10):3346-53.
1998: Yamamoto M; Briles D E; Yamamoto S; Ohmura M; Kiyono H; McGhee J R
A nontoxic adjuvant for mucosal immunity to pneumococcal surface protein A.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(8):4115-21.
1998: Itoh M; Ishihara K; Hiroi T; Lee B O; Maeda H; Iijima H; Yanagita M; Kiyono H; Hirano T
Deletion of bone marrow stromal cell antigen-1 (CD157) gene impaired systemic thymus independent-2 antigen-induced IgG3 and mucosal TD antigen-elicited IgA responses.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(8):3974-83.
1998: Kawabata S; Boyaka P N; Coste M; Fujihashi K; Yamamoto M; McGhee J R; Kiyono H
Intraepithelial lymphocytes from villus tip and crypt portions of the murine small intestine show distinct characteristics.
Gastroenterology 1998;115(4):866-73.
1998: Nguyen H H; Boyaka P N; Moldoveanu Z; Novak M J; Kiyono H; McGhee J R; Mestecky J
Influenza virus-infected epithelial cells present viral antigens to antigen-specific CD8+ cytotoxic T lymphocytes.
Journal of virology 1998;72(5):4534-6.
1998: Yuki Y; Fujihashi K; Yamamoto M; McGhee J R; Kiyono H
Human milk proteins including secretory IgA fail to elicit tolerance after feeding.
International immunology 1998;10(4):537-45.
1998: Sugimoto M; Shimaoka M; Hosotsubo K; Tanigami H; Taenaka N; Kiyono H; Yoshiya I
Up-regulation of Fas ligand (FasL) mRNA expression in peripheral blood mononuclear cells (PBMC) after major surgery.
Clinical and experimental immunology 1998;112(1):120-5.
1998: Yamamoto M; Fujihashi K; Kawabata K; McGhee J R; Kiyono H
A mucosal intranet: intestinal epithelial cells down-regulate intraepithelial, but not peripheral, T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(5):2188-96.
1998: Kweon M N; Fujihashi K; VanCott J L; Higuchi K; Yamamoto M; McGhee J R; Kiyono H
Lack of orally induced systemic unresponsiveness in IFN-gamma knockout mice.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(4):1687-93.
1998: Kawabata S; Miller C J; Lehner T; Fujihashi K; Kubota M; McGhee J R; Imaoka K; Hiroi T; Kiyono H
Induction of Th2 cytokine expression for p27-specific IgA B cell responses after targeted lymph node immunization with simian immunodeficiency virus antigens in rhesus macaques.
The Journal of infectious diseases 1998;177(1):26-33.
1997: Yamada K; Shimaoka M; Nagayama K; Hiroi T; Kiyono H; Honda T
Bacterial invasion induces interleukin-7 receptor expression in colonic epithelial cell line, T84.
European journal of immunology 1997;27(12):3456-60.
1997: Kawabata S; Boyaka P N; Coste M; Fujihashi K; Hamada S; McGhee J R; Kiyono H
A novel alkaline phosphatase-based isolation method allows characterization of intraepithelial lymphocytes from villi tip and crypt regions of murine small intestine.
Biochemical and biophysical research communications 1997;241(3):797-802.
1997: Pascual D W; Coste M; Boyaka P N; Kiyono H; McGhee J R
Spontaneously hypertensive rat: cholera toxin converts suppression to immunity through a Th2 cell-IL-4 pathway.
The American journal of physiology 1997;273(4 Pt 2):R1509-18.
1997: Fujihashi K; McGhee J R; Yamamoto M; Peschon J J; Kiyono H
An interleukin-7 internet for intestinal intraepithelial T cell development: knockout of ligand or receptor reveal differences in the immunodeficient state.
European journal of immunology 1997;27(9):2133-8.
1997: van Ginkel F W; McGhee J R; Liu C; Simecka J W; Yamamoto M; Frizzell R A; Sorscher E J; Kiyono H; Pascual D W
Adenoviral gene delivery elicits distinct pulmonary-associated T helper cell responses to the vector and to its transgene.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(2):685-93.
1997: Ban E M; van Ginkel F W; Simecka J W; Kiyono H; Robinson H L; McGhee J R
Mucosal immunization with DNA encoding influenza hemagglutinin.
Vaccine 1997;15(8):811-3.
1997: Yamamoto M; Kweon M N; Kiyono H
[The mechanisms of oral tolerance]
Nippon rinsho. Japanese journal of clinical medicine 1997;55(6):1444-9.
1997: Takahashi I; Kiyono H; Hamada S
CD4+ T-cell population mediates development of inflammatory bowel disease in T-cell receptor alpha chain-deficient mice.
Gastroenterology 1997;112(6):1876-86.
1997: Kubota M; Miller C J; Imaoka K; Kawabata S; Fujihashi K; McGhee J R; Kiyono H
Oral immunization with simian immunodeficiency virus p55gag and cholera toxin elicits both mucosal IgA and systemic IgG immune responses in nonhuman primates.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(11):5321-9.
1997: Yamamoto S; Kiyono H; Yamamoto M; Imaoka K; Fujihashi K; Van Ginkel F W; Noda M; Takeda Y; McGhee J R
A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5267-72.
1997: Yamamoto S; Takeda Y; Yamamoto M; Kurazono H; Imaoka K; Yamamoto M; Fujihashi K; Noda M; Kiyono H; McGhee J R
Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrheagenicity but retain adjuvanticity.
The Journal of experimental medicine 1997;185(7):1203-10.
1997: Vancott J L; Kweon M; Fujihashi K; Yamamoto M; Marinaro M; Kiyono H; McGhee J R
Helper T subsets and cytokines for mucosal immunity and tolerance.
Behring Institute Mitteilungen 1997;(98):44-52.
1997: Marinaro M; Boyaka P N; Finkelman F D; Kiyono H; Jackson R J; Jirillo E; McGhee J R
Oral but not parenteral interleukin (IL)-12 redirects T helper 2 (Th2)-type responses to an oral vaccine without altering mucosal IgA responses.
The Journal of experimental medicine 1997;185(3):415-27.
1997: Yanagita M; Hiroi T; Kiyono H
[Mucosal immune system and mucosal vaccine]
Nippon rinsho. Japanese journal of clinical medicine 1997;55(2):492-501.
1997: Yamamoto M; McDaniel L S; Kawabata K; Briles D E; Jackson R J; McGhee J R; Kiyono H
Oral immunization with PspA elicits protective humoral immunity against Streptococcus pneumoniae infection.
Infection and immunity 1997;65(2):640-4.
1997: Wallace M; Scharko A M; Pauza C D; Fisch P; Imaoka K; Kawabata S; Fujihashi K; Kiyono H; Tanaka Y; Bloom B R; Malkovsky M
Functional gamma delta T-lymphocyte defect associated with human immunodeficiency virus infections.
Molecular medicine (Cambridge, Mass.) 1997;3(1):60-71.
1997: Yamamoto M; Fujihashi K; Hiroi T; McGhee J R; Van Dyke T E; Kiyono H
Molecular and cellular mechanisms for periodontal diseases: role of Th1 and Th2 type cytokines in induction of mucosal inflammation.
Journal of periodontal research 1997;32(1 Pt 2):115-9.
1997: Fujihashi K; Kweon M N; Kiyono H; VanCott J L; van Ginkel F W; Yamamoto M; McGhee J R
A T cell/B cell/epithelial cell internet for mucosal inflammation and immunity.
Springer seminars in immunopathology 1997;18(4):477-94.
1996: Marinaro M; Boyaka P N; Jackson R J; Finkelman F D; Kiyono H; McGhee J R
Interleukin-12 alters helper T-cell subsets and antibody profiles induced by the mucosal adjuvant cholera toxin.
Annals of the New York Academy of Sciences 1996;795():361-5.
1996: Elson C O; Beagley K W; Sharmanov A T; Fujihashi K; Kiyono H; Tennyson G S; Cong Y; Black C A; Ridwan B W; McGhee J R
Hapten-induced model of murine inflammatory bowel disease: mucosa immune responses and protection by tolerance.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(5):2174-85.
1996: Nakagawa I; Takahashi I; Kiyono H; McGhee J R; Hamada S
Oral immunization with the B subunit of the heat-labile enterotoxin of Escherichia coli induces early Th1 and late Th2 cytokine expression in Peyer's patches.
The Journal of infectious diseases 1996;173(6):1428-36.
1996: Okahashi N; Yamamoto M; Vancott J L; Chatfield S N; Roberts M; Bluethmann H; Hiroi T; Kiyono H; McGhee J R
Oral immunization of interleukin-4 (IL-4) knockout mice with a recombinant Salmonella strain or cholera toxin reveals that CD4+ Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin A responses.
Infection and immunity 1996;64(5):1516-25.
1996: VanCott J L; Kobayashi T; Yamamoto M; Pillai S; McGhee J R; Kiyono H
Induction of pneumococcal polysaccharide-specific mucosal immune responses by oral immunization.
Vaccine 1996;14(5):392-8.
1996: Fujihashi K; McGhee J R; Kweon M N; Cooper M D; Tonegawa S; Takahashi I; Hiroi T; Mestecky J; Kiyono H
gamma/delta T cell-deficient mice have impaired mucosal immunoglobulin A responses.
The Journal of experimental medicine 1996;183(4):1929-35.
1996: Fujihashi K; Kawabata S; Hiroi T; Yamamoto M; McGhee J R; Nishikawa S; Kiyono H
Interleukin 2 (IL-2) and interleukin 7 (IL-7) reciprocally induce IL-7 and IL-2 receptors on gamma delta T-cell receptor-positive intraepithelial lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(8):3613-8.
1996: Jackson R J; Fujihashi K; Kiyono H; McGhee J R
Luminometry: a novel bioluminescent immunoassay enhances the quantitation of mucosal and systemic antibody responses.
Journal of immunological methods 1996;190(2):189-97.
1996: Takahashi I; Kiyono H; Jackson R J; Fujihashi K; Staats H F; Hamada S; Clements J D; Bost K L; McGhee J R
Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine.
Infection and immunity 1996;64(4):1290-8.
1996: Takahashi I; Marinaro M; Kiyono H; Jackson R J; Nakagawa I; Fujihashi K; Hamada S; Clements J D; Bost K L; McGhee J R
Mechanisms for mucosal immunogenicity and adjuvancy of Escherichia coli labile enterotoxin.
The Journal of infectious diseases 1996;173(3):627-35.
1996: Fujihashi K; Yamamoto M; Hiroi T; Bamberg T V; McGhee J R; Kiyono H
Selected Th1 and Th2 cytokine mRNA expression by CD4(+) T cells isolated from inflamed human gingival tissues.
Clinical and experimental immunology 1996;103(3):422-8.
1996: Shimaoka M; Hiroi T; Kiyono H
[The IgA immune system for mucosal vaccine: role of levels one and two Th2 cytokine producing T cells]
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 1996;19(1):114-8.
1996: Yamamoto M; Vancott J L; Okahashi N; Marinaro M; Kiyono H; Fujihashi K; Jackson R J; Chatfield S N; Bluethmann H; McGhee J R
The role of Th1 and Th2 cells for mucosal IgA responses.
Annals of the New York Academy of Sciences 1996;778():64-71.
1996: Fujihashi K; McGhee J R; Yamamoto M; Hiroi T; Kiyono H
Role of gamma delta T cells in the regulation of mucosal IgA response and oral tolerance.
Annals of the New York Academy of Sciences 1996;778():55-63.
1996: VanCott J L; Staats H F; Pascual D W; Roberts M; Chatfield S N; Yamamoto M; Coste M; Carter P B; Kiyono H; McGhee J R
Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(4):1504-14.
1996: Jackson R J; Marinaro M; VanCott J L; Yamamoto M; Okahashi N; Fujihashi K; Kiyono H; Chatfield S N; McGhee J R
Mucosal immunity: regulation by helper T cells and a novel method for detection.
Journal of biotechnology 1996;44(1-3):209-16.
1996: Yamamoto M; Kawabata K; Fujihashi K; McGhee J R; Van Dyke T E; Bamberg T V; Hiroi T; Kiyono H
Absence of exogenous interleukin-4-induced apoptosis of gingival macrophages may contribute to chronic inflammation in periodontal diseases.
The American journal of pathology 1996;148(1):331-9.
1995: Marinaro M; Staats H F; Hiroi T; Jackson R J; Coste M; Boyaka P N; Okahashi N; Yamamoto M; Kiyono H; Bluethmann H; Fujihashi K; McGhee J R
Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4621-9.
1995: Hiroi T; Fujihashi K; McGhee J R; Kiyono H
Polarized Th2 cytokine expression by both mucosal gamma delta and alpha beta T cells.
European journal of immunology 1995;25(10):2743-51.
1995: Van Ginkel F W; Liu C; Simecka J W; Dong J Y; Greenway T; Frizzell R A; Kiyono H; McGhee J R; Pascual D W
Intratracheal gene delivery with adenoviral vector induces elevated systemic IgG and mucosal IgA antibodies to adenovirus and beta-galactosidase.
Human gene therapy 1995;6(7):895-903.
1995: Pascual D W; Beagley K W; Kiyono H; McGhee J R
Substance P promotes Peyer's patch and splenic B cell differentiation.
Advances in experimental medicine and biology 1995;371A():55-9.
1995: Aicher W K; Eibel H; Fujihashi K; Boehm T; Beagley K W; McGhee J R; Kiyono H
Analysis of intestinal intraepithelial lymphocyte (IEL) T cells in mice expressing anti-CD8 immunoglobulin transgenes.
Advances in experimental medicine and biology 1995;371A():125-8.
1995: Mega J; McGhee J R; Kiyono H
Characterization of cytokine producing T cells, TCR expression, and IgA plasma cells in salivary gland-associated tissues.
Advances in experimental medicine and biology 1995;371B():1103-8.
1994: Hiroi T; Fujihashi K; McGhee J R; Kiyono H
Characterization of cytokine-producing cells in mucosal effector sites: CD3+ T cells of Th1 and Th2 type in salivary gland-associated tissues.
European journal of immunology 1994;24(11):2653-8.
1994: Jackson R J; Staats H F; Xu-Amano J; Takahashi I; Kiyono H; Hudson M E; Gilley R M; Chatfield S N; McGhee J R
Oral vaccine models: multiple delivery systems employing tetanus toxoid.
Annals of the New York Academy of Sciences 1994;730():217-34.
1994: Xu-Amano J; Jackson R J; Fujihashi K; Kiyono H; Staats H F; McGhee J R
Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxin.
Vaccine 1994;12(10):903-11.
1994: Staats H F; Jackson R J; Marinaro M; Takahashi I; Kiyono H; McGhee J R
Mucosal immunity to infection with implications for vaccine development.
Current opinion in immunology 1994;6(4):572-83.
1994: Pascual D W; Kiyono H; McGhee J R
The enteric nervous and immune systems: interactions for mucosal immunity and inflammation.
ImmunoMethods 1994;5(1):56-72.
1994: Yamamoto M; Fujihashi K; Amano M; McGhee J R; Beagley K W; Kiyono H
Cytokine synthesis and apoptosis by intestinal intraepithelial lymphocytes: signaling of high density alpha beta T cell receptor+ and gamma delta T cell receptor+ T cells via T cell receptor-CD3 complex results in interferon-gamma and interleukin-5 production, while low density T cells undergo DNA fragmentation.
European journal of immunology 1994;24(6):1301-6.
1994: Di Fabio S; Mbawuike I N; Kiyono H; Fujihashi K; Couch R B; McGhee J R
Quantitation of human influenza virus-specific cytotoxic T lymphocytes: correlation of cytotoxicity and increased numbers of IFN-gamma producing CD8+ T cells.
International immunology 1994;6(1):11-9.
1994: McGhee J R; Kiyono H
Effective mucosal immunity. Current concepts for vaccine delivery and immune response analysis.
International journal of technology assessment in health care 1994;10(1):93-106.
1994: Fujihashi K; Yamamoto M; McGhee J R; Kiyono H
Function of alpha beta TCR+ and gamma delta TCR+ IELs for the gastrointestinal immune response.
International reviews of immunology 1994;11(1):1-14.
1994: McGhee J R; Xu-Amano J; Miller C J; Jackson R J; Fujihashi K; Staats H F; Kiyono H
The common mucosal immune system: from basic principles to enteric vaccines with relevance for the female reproductive tract.
Reproduction, fertility, and development 1994;6(3):369-79.
1993: Fujihashi K; Yamamoto M; McGhee J R; Kiyono H
alpha beta T cell receptor-positive intraepithelial lymphocytes with CD4+, CD8- and CD4+, CD8+ phenotypes from orally immunized mice provide Th2-like function for B cell responses.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(12):6681-91.
1993: Fujihashi K; Yamamoto M; McGhee J R; Beagley K W; Kiyono H
Function of alpha beta TCR+ intestinal intraepithelial lymphocytes: Th1- and Th2-type cytokine production by CD4+CD8- and CD4+CD8+ T cells for helper activity.
International immunology 1993;5(11):1473-81.
1993: Jackson R J; Fujihashi K; Xu-Amano J; Kiyono H; Elson C O; McGhee J R
Optimizing oral vaccines: induction of systemic and mucosal B-cell and antibody responses to tetanus toxoid by use of cholera toxin as an adjuvant.
Infection and immunity 1993;61(10):4272-9.
1993: Xu-Amano J; Kiyono H; Jackson R J; Staats H F; Fujihashi K; Burrows P D; Elson C O; Pillai S; McGhee J R
Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues.
The Journal of experimental medicine 1993;178(4):1309-20.
1993: McGhee J R; Fujihashi K; Xu-Amano J; Jackson R J; Elson C O; Beagley K W; Kiyono H
New perspectives in mucosal immunity with emphasis on vaccine development.
Seminars in hematology 1993;30(4 Suppl 4):3-12; discussion 13-5.
1993: Beagley K W; Fujihashi K; Black C A; Lagoo A S; Yamamoto M; McGhee J R; Kiyono H
The Mycobacterium tuberculosis 71-kDa heat-shock protein induces proliferation and cytokine secretion by murine gut intraepithelial lymphocytes.
European journal of immunology 1993;23(8):2049-52.
1993: Fujihashi K; Kono Y; Beagley K W; Yamamoto M; McGhee J R; Mestecky J; Kiyono H
Cytokines and periodontal disease: immunopathological role of interleukins for B cell responses in chronic inflamed gingival tissues.
Journal of periodontology 1993;64(5 Suppl):400-6.
1993: Fujihashi K; Beagley K W; Kono Y; Aicher W K; Yamamoto M; DiFabio S; Xu-Amano J; McGhee J R; Kiyono H
Gingival mononuclear cells from chronic inflammatory periodontal tissues produce interleukin (IL)-5 and IL-6 but not IL-2 and IL-4.
The American journal of pathology 1993;142(4):1239-50.
1993: Fujihashi K; McGhee J R; Beagley K W; McPherson D T; McPherson S A; Huang C M; Kiyono H
Cytokine-specific ELISPOT assay. Single cell analysis of IL-2, IL-4 and IL-6 producing cells.
Journal of immunological methods 1993;160(2):181-9.
1993: McGhee J R; Kiyono H
New perspectives in vaccine development: mucosal immunity to infections.
Infectious agents and disease 1993;2(2):55-73.
1993: Yamamoto M; Fujihashi K; Beagley K W; McGhee J R; Kiyono H
Cytokine synthesis by intestinal intraepithelial lymphocytes. Both gamma/delta T cell receptor-positive and alpha/beta T cell receptor-positive T cells in the G1 phase of cell cycle produce IFN-gamma and IL-5.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(1):106-14.
1992: Fujihashi K; Kono Y; Kiyono H
Effects of IL6 on B cells in mucosal immune response and inflammation.
Research in immunology 1992;143(7):744-9.
1992: Aicher W K; Fujihashi K; Yamamoto M; Kiyono H; Pitts A M; McGhee J R
Effects of the lpr/lpr mutation on T and B cell populations in the lamina propria of the small intestine, a mucosal effector site.
International immunology 1992;4(9):959-68.
1992: Ogawa T; Kusumoto Y; Kiyono H; McGhee J R; Hamada S
Occurrence of antigen-specific B cells following oral or parenteral immunization with Porphyromonas gingivalis fimbriae.
International immunology 1992;4(9):1003-10.
1992: McGhee J R; Yamamoto M; Kang D W; Eldridge J H; Mestecky J; Moldoveanu Z; Compans R; Kiyono H; Miller C; Marthas M
Isotype of anti-SIV responses in infected rhesus macaques and in animals immunized by mucosal routes.
AIDS research and human retroviruses 1992;8(8):1389.
1992: Miller C J; Kang D W; Marthas M; Moldoveanu Z; Kiyono H; Marx P; Eldridge J H; Mestecky J; McGhee J R
Genital secretory immune response to chronic simian immunodeficiency virus (SIV) infection: a comparison between intravenously and genitally inoculated rhesus macaques.
Clinical and experimental immunology 1992;88(3):520-6.
1992: Aicher W K; McGhee M L; McGhee J R; Moldoveanu Z; Kidd V J; Tomana M; Mestecky J; Eldridge J H; Meyer T F; Kiyono H
Properties of IgA-binding receptors on murine T cells: relative importance of Fc alpha R, beta-galactosyltransferase and anti-secretory component reactive proteins (ASCP).
Scandinavian journal of immunology 1992;35(4):469-86.
1992: Mega J; McGhee J R; Kiyono H
Cytokine- and Ig-producing T cells in mucosal effector tissues: analysis of IL-5- and IFN-gamma-producing T cells, T cell receptor expression, and IgA plasma cells from mouse salivary gland-associated tissues.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(7):2030-9.
1992: Xu-Amano J; Aicher W K; Taguchi T; Kiyono H; McGhee J R
Selective induction of Th2 cells in murine Peyer's patches by oral immunization.
International immunology 1992;4(4):433-45.
1992: Fujihashi K; Taguchi T; Aicher W K; McGhee J R; Bluestone J A; Eldridge J H; Kiyono H
Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help.
The Journal of experimental medicine 1992;175(3):695-707.
1992: Lue C; Kiyono H; Fujihashi K; McGhee J R; Mestecky J
The use of the hu-PBL-SCID mouse model to study lymphocyte homing and responsiveness to recall antigens.
Regional immunology 1992;4(2):86-90.
1992: Kiyono H; Bienenstock J; McGhee J R; Ernst P B
The mucosal immune system: features of inductive and effector sites to consider in mucosal immunization and vaccine development.
Regional immunology 1992;4(2):54-62.
1992: Pascual D W; Bost K L; Xu-Amano J; Kiyono H; McGhee J R
The cytokine-like action of substance P upon B cell differentiation.
Regional immunology 1992;4(2):100-4.
1992: Mega J; Fujihashi K; Kiyono H
Regulation of mucosal immune responses by T lymphocytes: the effect of chronic CD4+ T cell deficiency on IgA synthesis.
Regional immunology 1992;4(2):70-8.
1992: Marthas M L; Miller C J; Sutjipto S; Higgins J; Torten J; Lohman B L; Unger R E; Ramos R A; Kiyono H; McGhee J R
Efficacy of live-attenuated and whole-inactivated simian immunodeficiency virus vaccines against vaginal challenge with virulent SIV.
Journal of medical primatology 1992;21(2-3):99-107.
1992: Aicher W K; Fujihashi K; Taguchi T; McGhee J R; Yamamoto M; Eldridge J H; Gay S; Kiyono H
Intestinal intraepithelial lymphocyte T cells are resistant to lpr gene-induced T cell abnormalities.
European journal of immunology 1992;22(1):137-45.
1992: McGhee J R; Mestecky J; Dertzbaugh M T; Eldridge J H; Hirasawa M; Kiyono H
The mucosal immune system: from fundamental concepts to vaccine development.
Vaccine 1992;10(2):75-88.
1992: McGhee J R; Kiyono H
Mucosal immunity to vaccines: current concepts for vaccine development and immune response analysis.
Advances in experimental medicine and biology 1992;327():3-12.
1992: Mega J; Fujihashi K; Yamamoto M; McGhee J R; Hirasawa M; Kiyono H
Cytokine production and T cell receptor expression by salivary gland T cells and intraepithelial T lymphocytes for the regulation of the IgA response.
Advances in experimental medicine and biology 1992;327():119-31.
1992: Xu-Amano J; Beagley K W; Mega J; Fujihashi K; Kiyono H; McGhee J R
Induction of T helper cells and cytokines for mucosal IgA responses.
Advances in experimental medicine and biology 1992;327():107-17.
1991: Pascual D W; McGhee J R; Kiyono H; Bost K L
Neuroimmune modulation of lymphocyte function--I. Substance P enhances immunoglobulin synthesis in lipopolysaccharide activated murine splenic B cell cultures.
International immunology 1991;3(12):1223-9.
1991: Taguchi T; Aicher W K; Fujihashi K; Yamamoto M; McGhee J R; Bluestone J A; Kiyono H
Novel function for intestinal intraepithelial lymphocytes. Murine CD3+, gamma/delta TCR+ T cells produce IFN-gamma and IL-5.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(11):3736-44.
1991: Pascual D W; Bost K L; Xu-Amano J; Kiyono H; McGhee J R
The regulation of antibody responses by mini-cytokines.
Acta neurologica 1991;13(4):343-9.
1991: Fujihashi K; McGhee J R; Lue C; Beagley K W; Taga T; Hirano T; Kishimoto T; Mestecky J; Kiyono H
Human appendix B cells naturally express receptors for and respond to interleukin 6 with selective IgA1 and IgA2 synthesis.
The Journal of clinical investigation 1991;88(1):248-52.
1991: Pascual D W; Xu-Amano J C; Kiyono H; McGhee J R; Bost K L
Substance P acts directly upon cloned B lymphoma cells to enhance IgA and IgM production.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(7):2130-6.
1991: Kono Y; Beagley K W; Fujihashi K; McGhee J R; Taga T; Hirano T; Kishimoto T; Kiyono H
Cytokine regulation of localized inflammation. Induction of activated B cells and IL-6-mediated polyclonal IgG and IgA synthesis in inflamed human gingiva.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(6):1812-21.
1991: Lue C; Kiyono H; McGhee J R; Fujihashi K; Kishimoto T; Hirano T; Mestecky J
Recombinant human interleukin 6 (rhIL-6) promotes the terminal differentiation of in vivo-activated human B cells into antibody-secreting cells.
Cellular immunology 1991;132(2):423-32.
1991: Ogawa T; Kono Y; McGhee M L; McGhee J R; Roberts J E; Hamada S; Kiyono H
Porphyromonas gingivalis-specific serum IgG and IgA antibodies originate from immunoglobulin-secreting cells in inflamed gingiva.
Clinical and experimental immunology 1991;83(2):237-44.
1991: McGhee J R; Fujihashi K; Beagley K W; Kiyono H
Role of interleukin-6 in human and mouse mucosal IgA plasma cell responses.
Immunologic research 1991;10(3-4):418-22.
1991: Kiyono H; Fujihashi K; Taguchi T; Aicher W K; McGhee J R
Regulatory functions for murine intraepithelial lymphocytes in mucosal responses.
Immunologic research 1991;10(3-4):324-30.
1991: McGhee J R; Fujihashi K; Lue C; Beagley K W; Mestecky J; Kiyono H
Role of IL-6 in human antigen-specific and polyclonal IgA responses.
Advances in experimental medicine and biology 1991;310():113-21.
1990: Ogawa T; Kusumoto Y; Hamada S; McGhee J R; Kiyono H
Bacteroides gingivalis-specific serum IgG and IgA subclass antibodies in periodontal diseases.
Clinical and experimental immunology 1990;82(2):318-25.
1990: Fujihashi K; Taguchi T; McGhee J R; Eldridge J H; Bruce M G; Green D R; Singh B; Kiyono H
Regulatory function for murine intraepithelial lymphocytes. Two subsets of CD3+, T cell receptor-1+ intraepithelial lymphocyte T cells abrogate oral tolerance.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(7):2010-9.
1990: Aicher W K; McGhee M L; McGhee J R; Eldridge J H; Beagley K W; Meyer T F; Kiyono H
Mouse IgA Fc receptor on CD3+ T cells. Molecular forms of IgA that bind to a 38-kDa Fc alpha R protein and development of an anti-Fc alpha R antisera.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(6):1745-53.
1990: Taguchi T; McGhee J R; Coffman R L; Beagley K W; Eldridge J H; Takatsu K; Kiyono H
Analysis of Th1 and Th2 cells in murine gut-associated tissues. Frequencies of CD4+ and CD8+ T cells that secrete IFN-gamma and IL-5.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(1):68-77.
1990: Tarkowski A; Lue C; Moldoveanu Z; Kiyono H; McGhee J R; Mestecky J
Immunization of humans with polysaccharide vaccines induces systemic, predominantly polymeric IgA2-subclass antibody responses.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(10):3770-8.
1990: Taguchi T; McGhee J R; Coffman R L; Beagley K W; Eldridge J H; Takatsu K; Kiyono H
Detection of individual mouse splenic T cells producing IFN-gamma and IL-5 using the enzyme-linked immunospot (ELISPOT) assay.
Journal of immunological methods 1990;128(1):65-73.
1990: Aicher W K; McGhee J R; Kiyono H
Candidates for the mouse Fc alpha R: beta-galactosyl transferase, secretory component and a 38-kDa protein.
Research in immunology 1990;141(1):90-4; discussion 105-8.
1990: Char D; Aicher W K; McGhee J R; Eldridge J H; Beagley K W; Kiyono H
Induction of Fc alpha receptor expression on T cells from murine Peyer's patch, spleen and thymus.
Regional immunology 1990;3(5):228-35.
1989: Fujihashi K; Kiyono H; Aicher W K; Green D R; Singh B; Eldridge J H; McGhee J R
Immunoregulatory function of CD3+, CD4-, and CD8- T cells. Gamma delta T cell receptor-positive T cells from nude mice abrogate oral tolerance.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(11):3415-22.
1989: Beagley K W; Eldridge J H; Lee F; Kiyono H; Everson M P; Koopman W J; Hirano T; Kishimoto T; McGhee J R
Interleukins and IgA synthesis. Human and murine interleukin 6 induce high rate IgA secretion in IgA-committed B cells.
The Journal of experimental medicine 1989;169(6):2133-48.
1989: McGhee J R; Mestecky J; Elson C O; Kiyono H
Regulation of IgA synthesis and immune response by T cells and interleukins.
Journal of clinical immunology 1989;9(3):175-99.
1989: Ogawa T; McGhee M L; Moldoveanu Z; Hamada S; Mestecky J; McGhee J R; Kiyono H
Bacteroides-specific IgG and IgA subclass antibody-secreting cells isolated from chronically inflamed gingival tissues.
Clinical and experimental immunology 1989;76(1):103-10.
1989: McGhee M L; Ogawa T; Pitts A M; Moldoveanu Z; Mestecky J; McGhee J R; Kiyono H
Cellular analysis of functional mononuclear cells from chronically inflamed gingival tissue.
Regional immunology 1989;2(2):103-10.
1989: Ogawa T; Tarkowski A; McGhee M L; Moldoveanu Z; Mestecky J; Hirsch H Z; Koopman W J; Hamada S; McGhee J R; Kiyono H
Analysis of human IgG and IgA subclass antibody-secreting cells from localized chronic inflammatory tissue.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(4):1150-8.
1989: Beagley K W; Fujihashi K; Aicher W; Xu J; Kiyono H; Eldridge J H; Bruce M G; Taguchi T; Green D R; Singh B
Mucosal homeostasis: role of interleukins, isotype-specific factors and contrasuppression in the IgA response.
Immunological investigations 1989;18(1-4):77-89.
1989: Tarkowski A; Lue C; Moldoveanu Z; Kiyono H; McGhee J R; Prchal J T; Halpern N B; Mestecky J
Systemic immunization for the induction of IgA responses.
Current topics in microbiology and immunology 1989;146():161-8.
1988: Beagley K W; Eldridge J H; Kiyono H; Everson M P; Koopman W J; Honjo T; McGhee J R
Recombinant murine IL-5 induces high rate IgA synthesis in cycling IgA-positive Peyer's patch B cells.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(6):2035-42.
1988: McGhee J R; Eldridge J H; Beagley K W; Kiyono H
The possible involvement of CD3+, CD4- and CD8- T cells in immune responses.
Annales de l'Institut Pasteur. Immunology 1988;139(2):193-9.
1988: Kitamura K; Kiyono H; Fujihashi K; Eldrige J H; Beagley K W; McGhee J R
Isotype-specific immunoregulation. Systemic antigen induces splenic T contrasuppressor cells which support IgM and IgG subclass but not IgA responses.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(5):1385-92.
1988: Fujihashi K; Kiyono H; Beagley K W; Eldridge J H; McGhee J R
Role of the galt contrasuppressor T cell circuit in isotype-specific immunoregulation.
Advances in experimental medicine and biology 1988;237():649-53.
1988: Kiyono H; Green D R; McGhee J R
Contrasuppression in the mucosal immune system.
Immunologic research 1988;7(1):67-81.
1987: Kitamura K; Kiyono H; Fujihashi K; Eldridge J H; Green D R; McGhee J R
Contrasuppressor cells that break oral tolerance are antigen-specific T cells distinct from T helper (L3T4+), T suppressor (Lyt-2+), and B cells.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(10):3251-9.
1987: Kiyono H; McGhee J R
Mucosal T cell networks: role of Fc alpha R+ T cells and Ig BF alpha in the regulation of the IgA response.
International reviews of immunology 1987;2(2):157-82.
1987: Kurita T; Kiyono H; McGhee M L; McGhee J R
Isotype specific immunoregulation: role of Fc alpha R+ T cells and IBF alpha in IgA responses.
Advances in experimental medicine and biology 1987;216A():81-7.
1987: Eldridge J H; Kiyono H; Suzuki I; Kitamura K; Kurita T; Beagley K W; McGhee M L; Michalek S M; Green D R; McGhee J R
Regulatory T cell networks in the secretory immune system.
Advances in experimental medicine and biology 1987;216A():45-55.
1987: Kitamura K; Suzuki I; Kiyono H; Kurita T; Berry A K; Green D R; McGhee J R
Isotype-specific immunoregulation: T contrasuppressor cells protect IgA responses in oral tolerance.
Advances in experimental medicine and biology 1987;216A():143-8.
1987: Beagley K W; Kiyono H; Alley C D; Eldridge J H; McGhee J R
Isolation of Peyer's patch T cell subsets involved in isotype specific immunoregulation.
Advances in experimental medicine and biology 1987;216A():177-83.

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