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Hiroshi Kiyono

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Il Gyu Kong; Jun Kunisawa; Shiho Kurokawa; Mio Mejima; Tomonori Nochi; Kazunari Okada; Ayuko Sato; Shintaro Sato; Shinichi Sawada; Haruko Takahashi; Masafumi Yamamoto; Yoshikazu Yuki; Kazunari Akiyoshi; David E Briles; Yusuke Inoue; Hiroshi Kiyono
Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by Streptococcus pneumoniae.
Takashi Kusu; Yuichi Maeda; Masaaki Murakami; Jun-ichi Nishimura; Meinoshin Okumura; Ryu Okumura; Hiroyuki Saiga; Yasunobu Arima; Koji Atarashi; Yoshiyuki Goto; Kenya Honda; Kayo Ikeda; Seong Gyu Jeon; Hisako Kayama; Makoto Kinoshita; Hiroshi Kiyono; Jun Kunisawa; Takashi Kurakawa; Yoshiyasu Ueda; Masahiro Yamamoto; Kiyoshi Takeda
Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine.
Yoshiko Fukuyama; Rebekah S Gilbert; Kosuke Kataoka; Hiroshi Kiyono; Jun Kunisawa; Jerry R McGhee; Shinichi Sekine; Daisuke Tokuhara; Yuka Tokuhara; Masato Yamamoto; Yoshikazu Yuki; Kazuyoshi Aso; Julia Davydova; Keiko Fujihashi; Kohtaro Fujihashi
Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses.

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All Publications

2013: Il Gyu Kong; Jun Kunisawa; Shiho Kurokawa; Mio Mejima; Tomonori Nochi; Kazunari Okada; Ayuko Sato; Shintaro Sato; Shinichi Sawada; Haruko Takahashi; Masafumi Yamamoto; Yoshikazu Yuki; Kazunari Akiyoshi; David E Briles; Yusuke Inoue; Hiroshi Kiyono
Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by Streptococcus pneumoniae.
Infection and immunity 2013;81(5):1625-34.
2013: Takashi Kusu; Yuichi Maeda; Masaaki Murakami; Jun-ichi Nishimura; Meinoshin Okumura; Ryu Okumura; Hiroyuki Saiga; Yasunobu Arima; Koji Atarashi; Yoshiyuki Goto; Kenya Honda; Kayo Ikeda; Seong Gyu Jeon; Hisako Kayama; Makoto Kinoshita; Hiroshi Kiyono; Jun Kunisawa; Takashi Kurakawa; Yoshiyasu Ueda; Masahiro Yamamoto; Kiyoshi Takeda
Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(2):774-83.
2013: Yoshiko Fukuyama; Rebekah S Gilbert; Kosuke Kataoka; Hiroshi Kiyono; Jun Kunisawa; Jerry R McGhee; Shinichi Sekine; Daisuke Tokuhara; Yuka Tokuhara; Masato Yamamoto; Yoshikazu Yuki; Kazuyoshi Aso; Julia Davydova; Keiko Fujihashi; Kohtaro Fujihashi
Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses.
PloS one 2013;8(4):e60453.
2013: Jun Kunisawa; Hiroshi Kiyono
Immune regulation and monitoring at the epithelial surface of the intestine.
Drug discovery today 2013;18(1-2):87-92.
2012: Takuma Shibata; Naoki Takemura; Natsuko Tanimura; Satoshi Uematsu; Yuji Motoi; Sachiko Akashi-Takamura; Shizuo Akira; Yoshiyuki Goto; Kumi Izawa; Thangaraj Karuppuchamy; Toshio Kitamura; Jiro Kitaura; Hiroshi Kiyono; Jun Kunisawa; Xiaobing Li; Kensuke Miyake
PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells.
International immunology 2012;24(10):613-23.
2012: Makoto Kinoshita; Hiroshi Kiyono; Jun Kunisawa; Takashi Kusu; Shimon Sakaguchi; Hisako Kayama; Tomoyuki Yamaguchi; Kiyoshi Takeda
Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(6):2869-78.
2012: Yoshikazu Yuki; Tomoko Hiroiwa; Tomoko Kohda; Il Gyu Kong; Shunji Kozaki; Masaharu Kuroda; Shiho Kurokawa; Mio Mejima; Tomonori Nochi; Yoko Takahashi; Daisuke Tokuhara; Hiroshi Kiyono
RNAi suppression of rice endogenous storage proteins enhances the production of rice-based Botulinum neutrotoxin type A vaccine.
Vaccine 2012;30(28):4160-6.
2012: Shintaro Sato; Hiroshi Kiyono
The mucosal immune system of the respiratory tract.
Current opinion in virology 2012;2(3):225-32.
2012: Jun Kunisawa; Yukiko Kurashima; Hiroshi Kiyono
Gut-associated lymphoid tissues for the development of oral vaccines.
Advanced drug delivery reviews 2012;64(6):523-30.
2012: Dae-Yong Kim; S Fukuyama; I G Kong; Chul-Hee Lee; T Nagatake; K Takamura; Y Yokota; Hiroshi Kiyono
Implications of nasopharynx-associated lymphoid tissue (NALT) in the development of allergic responses in an allergic rhinitis mouse model.
Allergy 2012;67(4):502-9.
2012: Shinsuke Takagi; Satoshi Tanaka; Shuichi Taniguchi; Takashi Watanabe; Takanori Hasegawa; Atsushi Hijikata; Hiroshi Kiyono; Haruhiko Koseki; Jun Kunisawa; Shinobu Mochizuki; Osamu Ohara; Takashi Saito; Yoriko Saito; Leonard D Shultz; Fumihiko Ishikawa
Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation.
Blood 2012;119(12):2768-77.
2012: Jun Kunisawa; Hiroshi Kiyono
Immunological function of sphingosine 1-phosphate in the intestine.
Nutrients 2012;4(3):154-66.
2012: Yoshiko Fujkuyama; Rebekah S Gilbert; Kosuke Kataoka; Hiroshi Kiyono; Jerry R McGhee; Daisuke Tokuhara; Yoshikazu Yuki; Kohtaro Fujihashi
Novel vaccine development strategies for inducing mucosal immunity.
Expert review of vaccines 2012;11(3):367-79.
2012: Haruyo Nakajima-Adachi; Mamoru Totsuka; Yoshio Wakatsuki; Erika Hiraide; Hiroshi Kiyono; Emiko Koike; Satoshi Hachimura
Two distinct epitopes on the ovalbumin 323-339 peptide differentiating CD4⁺T cells into the Th2 or Th1 phenotype.
Bioscience, biotechnology, and biochemistry 2012;76(10):1979-81.
2012: Yukiko Kurashima; Sachiko Nakajima; Tomonori Nochi; Shintaro Sato; Hiroko Tsutsui; Takeaki Amiya; Kumiko Fujisawa; Takeshi Haraguchi; Hideo Iba; Hideki Iijima; Masato Kubo; Jun Kunisawa; Hiroshi Kiyono
Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors.
Nature communications 2012;3():1034.
2012: Seong Gyu Jeon; Hisako Kayama; Hiroshi Kiyono; Takashi Kusu; Ji Su Ma; Koji Nomoto; Ryu Okumura; Takuya Takahashi; Hirokazu Tsuji; Noriko M Tsuji; Yoshiyasu Ueda; Masahiro Yamamoto; Hiroki Yoshida; Takashi Asahara; Hiromitsu Hara; Kiyoshi Takeda
Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon.
PLoS pathogens 2012;8(5):e1002714.
2012: Jun Kunisawa; Hiroshi Kiyono
Alcaligenes is Commensal Bacteria Habituating in the Gut-Associated Lymphoid Tissue for the Regulation of Intestinal IgA Responses.
Frontiers in immunology 2012;3():65.
2012: Jun Kunisawa; Eri Hashimoto; Izumi Ishikawa; Hiroshi Kiyono
A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo.
PloS one 2012;7(2):e32094.
2011: Natsumi Takeyama; Yoshikazu Yuki; Hiroshi Kiyono
[Current progress in the development of mucosal vaccines].
Nihon rinsho. Japanese journal of clinical medicine 2011;69(9):1555-60.
2011: Ogawa Michinaga; Yuko Yoshikawa; Taira Kobayashi; Hitomi Mimuro; Makoto Fukumatsu; Kotaro Kiga; Zhenzi Piao; Hiroshi Ashida; Mitsutaka Yoshida; Shigeru Kakuta; Tomohiro Koyama; Yoshiyuki Goto; Takahiro Nagatake; Shinya Nagai; Hiroshi Kiyono; Magdalena Kawalec; Jean-Marc Reichhart; Chihiro Sasakawa
A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens.
Cell host & microbe 2011;9(5):376-89.
2011: Dong-Young Kim; Ayuko Sato; Satoshi Fukuyama; Hiroshi Sagara; Takahiro Nagatake; Il Gyu Kong; Kaoru Goda; Tomonori Nochi; Jun Kunisawa; Shintaro Sato; Yoshifumi Yokota; Chul Hee Lee; Hiroshi Kiyono
The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(7):4253-62.
2011: Yoshiyuki Goto; Hiroshi Kiyono
Epithelial cell microRNAs in gut immunity.
Nature immunology 2011;12(3):195-7.
2011: Jun Kunisawa; Hiroshi Kiyono
Peaceful mutualism in the gut: revealing key commensal bacteria for the creation and maintenance of immunological homeostasis.
Cell host & microbe 2011;9(2):83-4.
2011: Kazutaka Terahara; Tomonori Nochi; Masato Yoshida; Yuko Takahashi; Yoshiyuki Goto; Hirotsugu Hatai; Shiho Kurokawa; Myoung Ho Jang; Mi-Na Kweon; Steven E Domino; Takachika Hiroi; Yoshikazu Yuki; Yasuko Tsunetsugu-Yokota; Kazuo Kobayashi; Hiroshi Kiyono
Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress.
Biochemical and biophysical research communications 2011;404(3):822-8.
2011: Kazunari Okada; Tatsuya Yamasoba; Hiroshi Kiyono
Craniofacial mucosal immune system: importance of its unique organogenesis and function in the development of a mucosal vaccine.
Advances in oto-rhino-laryngology 2011;72():31-6.
2010: Yoshikazu Yuki; Tomonori Nochi; Norihiro Harada; Yuko Katakai; Hiroaki Shibata; Mio Mejima; Takashi Kohda; Daisuke Tokuhara; Shiho Kurokawa; Yuko Takahashi; Fumiko Ono; Shunji Kozaki; Keiji Terao; Hideo Tsukada; Hiroshi Kiyono
In vivo molecular imaging analysis of a nasal vaccine that induces protective immunity against botulism in nonhuman primates.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(9):5436-43.
2010: Daisuke Tokuhara; Yoshikazu Yuki; Tomonori Nochi; Toshio Kodama; Mio Mejima; Shiho Kurokawa; Yuko Takahashi; Masanobu Nanno; Ushio Nakanishi; Fumio Takaiwa; Takeshi Honda; Hiroshi Kiyono
Secretory IgA-mediated protection against V. cholerae and heat-labile enterotoxin-producing enterotoxigenic Escherichia coli by rice-based vaccine.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(19):8794-9.
2010: Jun Kunisawa; Hiroshi Kiyono
Aberrant interaction of the gut immune system with environmental factors in the development of food allergies.
Current allergy and asthma reports 2010;10(3):215-21.
2010: R Mavichak; T Takano; Hidehiro Kondo; Ikuo Hirono; S Wada; Kishio Hatai; H Inagawa; Y Takahashi; T Yoshimura; Hiroshi Kiyono; Y Yuki; Takashi Aoki
The effect of liposome-coated recombinant protein VP28 against white spot syndrome virus in kuruma shrimp, Marsupenaeus japonicus.
Journal of fish diseases 2010;33(1):69-74.
2009: Tsuyoshi Umehara; Jun Udagawa; Kaoru Takamura; Mitsuhiro Kimura; Ryotaro Ishimitsu; Hiroshi Kiyono; Hideyuki Kawauchi; Hiroki Otani
Role of interleukin-15 in the development of mouse olfactory nerve.
Congenital anomalies 2009;49(4):253-7.
2009: Tomonori Nochi; Yoshikazu Yuki; Yuko Katakai; Hiroaki Shibata; Daisuke Tokuhara; Mio Mejima; Shiho Kurokawa; Yuko Takahashi; Ushio Nakanishi; Fumiko Ono; Hitomi Mimuro; Chihiro Sasakawa; Fumio Takaiwa; Keiji Terao; Hiroshi Kiyono
A rice-based oral cholera vaccine induces macaque-specific systemic neutralizing antibodies but does not influence pre-existing intestinal immunity.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(10):6538-44.
2009: Koji Hase; Kazuya Kawano; Tomonori Nochi; Gemilson Soares Pontes; Shinji Fukuda; Masashi Ebisawa; Kazunori Kadokura; Toru Tobe; Yumiko Fujimura; Sayaka Kawano; Atsuko Yabashi; Satoshi Waguri; Gaku Nakato; Shunsuke Kimura; Takaya Murakami; Mitsutoshi Iimura; Kimiyo Hamura; Shin-Ichi Fukuoka; Anson W Lowe; Kikuji Itoh; Hiroshi Kiyono; Hiroshi Ohno
Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response.
Nature 2009;462(7270):226-30.
2009: Ayuko Sato; Hiroshi Kiyono
[The mucosal immune system: new strategy for the control of allergic diseases].
Nihon rinsho. Japanese journal of clinical medicine 2009;67(11):2194-9.
2009: Takahiro Nagatake; Satoshi Fukuyama; Dong-Young Kim; Kaoru Goda; Osamu Igarashi; Shintaro Sato; Tomonori Nochi; Hiroshi Sagara; Yoshifumi Yokota; Anton M Jetten; Tsuneyasu Kaisho; Shizuo Akira; Hitomi Mimuro; Chihiro Sasakawa; Yoshinori Fukui; Kohtaro Fujihashi; Taishin Akiyama; Jun-Ichiro Inoue; Josef M Penninger; Jun Kunisawa; Hiroshi Kiyono
Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity.
The Journal of experimental medicine 2009;206(11):2351-64.
2009: Yoshikazu Yuki; Daisuke Tokuhara; Tomonori Nochi; Hiroshi Yasuda; Mio Mejima; Shiho Kurokawa; Yuko Takahashi; Nobuhiro Kataoka; Ushio Nakanishi; Yukari Hagiwara; Kohtaro Fujihashi; Fumio Takaiwa; Hiroshi Kiyono
Oral MucoRice expressing double-mutant cholera toxin A and B subunits induces toxin-specific neutralising immunity.
Vaccine 2009;27(43):5982-8.
2009: Yoshikazu Yuki; Hiroshi Kiyono
Mucosal vaccines: novel advances in technology and delivery.
Expert review of vaccines 2009;8(8):1083-97.
2009: Kohtaro Fujihashi; Hiroshi Kiyono
Mucosal immunosenescence: new developments and vaccines to control infectious diseases.
Trends in immunology 2009;30(7):334-43.
2009: Donghyun Kim; SH Kim; Eun-Jin Park; Jiyoung Kim; Sang-Heon Cho; Junko Kagawa; Naoko Arai; Kunisawa Jun; Hiroshi Kiyono; Sunyoung Kim
Suppression of allergic diarrhea in murine ovalbumin-induced allergic diarrhea model by PG102, a water-soluble extract prepared from Actinidia arguta.
International archives of allergy and immunology 2009;150(2):164-71.
2008: Jiri Mestecky; Huan Nguyen; Cecil Czerkinsky; Hiroshi Kiyono
Oral immunization: an update.
Current opinion in gastroenterology 2008;24(6):713-9.
2008: Jun Kunisawa; Tomonori Nochi; Hiroshi Kiyono
Immunological commonalities and distinctions between airway and digestive immunity.
Trends in immunology 2008;29(11):505-13.
2008: Yoshikazu Yuki; Hiroshi Kiyono
[MucoRice: development of rice-based oral vaccine].
Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology 2008;31(5):369-74.
2008: Christopher Marlowe A Caipang; Noel Verjan Garcia; Ei Lin Ooi; Hidehiro Kondo; Ikuo Hirono; Takashi Aoki; Hiroshi Kiyono; Yoshikazu Yuki
Enhanced survival of shrimp, Penaeus (Marsupenaeus) japonicus from white spot syndrome disease after oral administration of recombinant VP28 expressed in Brevibacillus brevis.
Fish & shellfish immunology 2008;25(3):315-20.
2008: Satoshi Uematsu; Kosuke Fujimoto; Myoung Ho Jang; Bo-Gie Yang; Yun-Jae Jung; Mika Nishiyama; Shintaro Sato; Tohru Tsujimura; Masafumi Yamamoto; Yoshifumi Yokota; Hiroshi Kiyono; Masayuki Miyasaka; Ken J Ishii; Shizuo Akira
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.
Nature immunology 2008;9(7):769-76.
2008: Noel Verjan Garcia; Ei Lin Ooi; Tomonori Nochi; Hidehiro Kondo; Ikuo Hirono; Takashi Aoki; Hiroshi Kiyono; Yoshikazu Yuki
A soluble nonglycosylated recombinant infectious hematopoietic necrosis virus (IHNV) G-protein induces IFNs in rainbow trout (Oncorhynchus mykiss).
Fish & shellfish immunology 2008;25(1-2):170-80.
2008: Toshihiko Kobayashi; Koichiro Takahashi; Yoshinori Nagai; Takuma Shibata; Masako Otani; Shozo Izui; Shizuo Akira; Yoshiyuki Gotoh; Hiroshi Kiyono; Kensuke Miyake
Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice.
International immunology 2008;20(7):881-91.
2008: Kazutaka Terahara; Masato Yoshida; Osamu Igarashi; Tomonori Nochi; Gemilson Soares Pontes; Koji Hase; Hiroshi Ohno; Shiho Kurokawa; Mio Mejima; Naoko Takayama; Yoshikazu Yuki; Anson W Lowe; Hiroshi Kiyono
Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(12):7840-6.
2008: Fumiki Momoi; Tomomi Hashizume; Tomoko Kurita-Ochiai; Yoshikazu Yuki; Hiroshi Kiyono; Masafumi Yamamoto
Nasal vaccination with the 40-kilodalton outer membrane protein of Porphyromonas gingivalis and a nontoxic chimeric enterotoxin adjuvant induces long-term protective immunity with reduced levels of immunoglobulin E antibodies.
Infection and immunity 2008;76(6):2777-84.
2008: Ei Lin Ooi; Noel Verjan Garcia; Ikuo Hirono; Tomonori Nochi; Hidehiro Kondo; Takashi Aoki; Hiroshi Kiyono; Yoshikazu Yuki
Biological characterisation of a recombinant Atlantic salmon type I interferon synthesized in Escherichia coli.
Fish & shellfish immunology 2008;24(5):506-13.
2008: Jun Kunisawa; Masashi Gohda; Yukiko Kurashima; Izumi Ishikawa; Morio Higuchi; Hiroshi Kiyono
Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.
Blood 2008;111(9):4646-52.
2008: Masashi Gohda; Jun Kunisawa; Fumi Miura; Yuki Kagiyama; Yukiko Kurashima; Morio Higuchi; Izumi Ishikawa; Ikuko Ogahara; Hiroshi Kiyono
Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(8):5335-43.
2008: Sun-Young Chang; Hye-Ran Cha; Osamu Igarashi; Paul D Rennert; adrien kissenpfennig; Bernard Malissen; Masanobu Nanno; Hiroshi Kiyono; Mi-Na Kweon
Cutting edge: Langerin+ dendritic cells in the mesenteric lymph node set the stage for skin and gut immune system cross-talk.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):4361-5.
2008: Tomomi Hashizume; Atsushi Togawa; Tomonori Nochi; Osamu Igarashi; Mi-Na Kweon; Hiroshi Kiyono; Masafumi Yamamoto
Peyer's patches are required for intestinal immunoglobulin A responses to Salmonella spp.
Infection and immunity 2008;76(3):927-34.
2008: Yukiko Kurashima; Jun Kunisawa; Hiroshi Kiyono
[Applicable strategies for the mucosal immune system in the regulation of allergic diseases].
Arerugī = [Allergy] 2008;57(2):87-94.
2008: Ei Lin Ooi; Noel Verjan Garcia; Ikumi Haraguchi; Takeo Oshima; Hidehiro Kondo; Ikuo Hirono; Takashi Aoki; Hiroshi Kiyono; Yoshikazu Yuki
Innate immunomodulation with recombinant interferon-alpha enhances resistance of rainbow trout (Oncorhynchus mykiss) to infectious hematopoietic necrosis virus.
Developmental and comparative immunology 2008;32(10):1211-20.
2007: Tomonori Nochi; Yoshikazu Yuki; Akiko Matsumura; Mio Mejima; Kazutaka Terahara; Dong-Young Kim; Satoshi Fukuyama; Kiyoko Iwatsuki-Horimoto; Yoshihiro Kawaoka; Tomoko Kohda; Shunji Kozaki; Osamu Igarashi; Hiroshi Kiyono
A novel M cell-specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses.
The Journal of experimental medicine 2007;204(12):2789-96.
2007: Kaoru Takamura; Satoshi Fukuyama; Tsuyoshi Nagatake; Dong-Young Kim; Aya Kawamura; Hideyuki Kawauchi; Hiroshi Kiyono
Regulatory role of lymphoid chemokine CCL19 and CCL21 in the control of allergic rhinitis.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):5897-906.
2007: Jun Kunisawa; Yukiko Kurashima; Morio Higuchi; Masashi Gohda; Izumi Ishikawa; Ikuko Ogahara; Namju Kim; Miki Shimizu; Hiroshi Kiyono
Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium.
The Journal of experimental medicine 2007;204(10):2335-48.
2007: Yoshikazu Yuki; Tomonori Nochi; Hiroshi Kiyono
Progress towards an AIDS mucosal vaccine: an overview.
Tuberculosis (Edinburgh, Scotland) 2007;87 Suppl 1():S35-44.
2007: Yukiko Kurashima; Jun Kunisawa; Morio Higuchi; Masashi Gohda; Izumi Ishikawa; Naoko Takayama; Miki Shimizu; Hiroshi Kiyono
Sphingosine 1-phosphate-mediated trafficking of pathogenic Th2 and mast cells for the control of food allergy.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(3):1577-85.
2007: Seii Ohka; Hiroko Igarashi; Noriyo Nagata; Mai Sakai; Satoshi Koike; Tomonori Nochi; Hiroshi Kiyono; Akio Nomoto
Establishment of a poliovirus oral infection system in human poliovirus receptor-expressing transgenic mice that are deficient in alpha/beta interferon receptor.
Journal of virology 2007;81(15):7902-12.
2007: Tomonori Nochi; Hidenori Takagi; Yoshikazu Yuki; Lijun Yang; Takehiro Masumura; Mio Mejima; Ushio Nakanishi; Akiko Matsumura; Akihiro Uozumi; Takachika Hiroi; Shigeto Morita; Kunisuke Tanaka; Fumio Takaiwa; Hiroshi Kiyono
Rice-based mucosal vaccine as a global strategy for cold-chain- and needle-free vaccination.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(26):10986-91.
2007: Shigenori Nagai; Hitomi Mimuro; Taketo Yamada; Yukiko Baba; Kazuyo Moro; Tomonori Nochi; Hiroshi Kiyono; Toshihiko Suzuki; Chihiro Sasakawa; Shigeo Koyasu
Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(21):8971-6.
2007: Naoko Takayama; Osamu Igarashi; Mi-Na Kweon; Hiroshi Kiyono
Regulatory role of Peyer's patches for the inhibition of OVA-induced allergic diarrhea.
Clinical immunology (Orlando, Fla.) 2007;123(2):199-208.
2007: Hiroshi Tamagawa; Takachika Hiroi; Tsunekazu Mizushima; Toshinori Ito; Hikaru Matsuda; Hiroshi Kiyono
Therapeutic effects of roxithromycin in interleukin-10-deficient colitis.
Inflammatory bowel diseases 2007;13(5):547-56.
2007: Jun Kunisawa; Yukiko Kurashima; Masashi Gohda; Morio Higuchi; Izumi Ishikawa; Fumi Miura; Ikuko Ogahara; Hiroshi Kiyono
Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production.
Blood 2007;109(9):3749-56.
2007: Shin Makita; Takanori Kanai; Yasuhiro Nemoto; Teruji Totsuka; Ryuichi Okamoto; Kiichiro Tsuchiya; Masafumi Yamamoto; Hiroshi Kiyono; Mamoru Watanabe
Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):4937-46.
2007: Satoshi Fukuyama; Hiroshi Kiyono
Neuroregulator RET initiates Peyer's-patch tissue genesis.
Immunity 2007;26(4):393-5.
2007: Jerry R McGhee; Jun Kunisawa; Hiroshi Kiyono
Gut lymphocyte migration: we are halfway 'home'.
Trends in immunology 2007;28(4):150-3.
2007: Namju Kim; Jun Kunisawa; Mi-Na Kweon; Geun Eog Ji; Hiroshi Kiyono
Oral feeding of Bifidobacterium bifidum (BGN4) prevents CD4(+) CD45RB(high) T cell-mediated inflammatory bowel disease by inhibition of disordered T cell activation.
Clinical immunology (Orlando, Fla.) 2007;123(1):30-9.
2007: Jun Kunisawa; Ichiro Takahashi; Hiroshi Kiyono
Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine.
Immunological reviews 2007;215():136-53.
2007: Jun Kunisawa; Masashi Gohda; Hiroshi Kiyono
[Uniqueness of the mucosal immune system for the development of prospective mucosal vaccine].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2007;127(2):319-26.
2006: Massimo Maddaloni; Herman F Staats; Dagmara Mierzejewska; Teri Hoyt; Amy Robinson; Gayle Callis; Shunji Kozaki; Hiroshi Kiyono; Jerry R McGhee; Kohtaro Fujihashi; David W Pascual
Mucosal vaccine targeting improves onset of mucosal and systemic immunity to botulinum neurotoxin A.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5524-32.
2006: Satoshi Fukuyama; Tsuyoshi Nagatake; Dong-Young Kim; Kaoru Takamura; Eun Jeong Park; Tsuneyasu Kaisho; Norimitsu Tanaka; Yuichi Kurono; Hiroshi Kiyono
Cutting edge: Uniqueness of lymphoid chemokine requirement for the initiation and maturation of nasopharynx-associated lymphoid tissue organogenesis.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(7):4276-80.
2006: Yukari Hagiwara; Yuki I Kawamura; Kosuke Kataoka; Bibi Rahima; Raymond J Jackson; Katsuhiro Komase; Taeko Dohi; Prosper N Boyaka; Yoshifumi Takeda; Hiroshi Kiyono; Jerry R McGhee; Kohtaro Fujihashi
A second generation of double mutant cholera toxin adjuvants: enhanced immunity without intracellular trafficking.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):3045-54.
2006: Alexandra Duverger; Raymond J Jackson; Frederik W van Ginkel; Romy Fischer; Angela Tafaro; Stephen H Leppla; Kohtaro Fujihashi; Hiroshi Kiyono; Jerry R McGhee; Prosper N Boyaka
Bacillus anthracis edema toxin acts as an adjuvant for mucosal immune responses to nasally administered vaccine antigens.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1776-83.
2006: Myoung Ho Jang; Nagako Sougawa; Toshiyuki Tanaka; Takako Hirata; Takachika Hiroi; Kazuo Tohya; Zijin Guo; Eiji Umemoto; Yukihiko Ebisuno; Bo-Gie Yang; Ju-Young Seoh; Martin Lipp; Hiroshi Kiyono; Masayuki Miyasaka
CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(2):803-10.
2006: Tomonori Nochi; Hiroshi Kiyono
Innate immunity in the mucosal immune system.
Current pharmaceutical design 2006;12(32):4203-13.
2005: Yoshikazu Yuki; Chisato Hara-Yakoyama; Abigail A E Guadiz; Shigezo Udaka; Hiroshi Kiyono; Subhendra Chatterjee
Production of a recombinant cholera toxin B subunit-insulin B chain peptide hybrid protein by Brevibacillus choshinensis expression system as a nasal vaccine against autoimmune diabetes.
Biotechnology and bioengineering 2005;92(7):803-9.
2005: Hidenori Takagi; Takachika Hiroi; Lijun Yang; Yoshifumi Tada; Yoshikazu Yuki; Kaoru Takamura; Ryotaro Ishimitsu; Hideyuki Kawauchi; Hiroshi Kiyono; Fumio Takaiwa
A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th2-mediated IgE responses.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(48):17525-30.
2005: Jun Kunisawa; Satoshi Fukuyama; Hiroshi Kiyono
Mucosa-associated lymphoid tissues in the aerodigestive tract: their shared and divergent traits and their importance to the orchestration of the mucosal immune system.
Current molecular medicine 2005;5(6):557-72.
2005: Mari Ohmura; Masafumi Yamamoto; Chikako Tomiyama-Miyaji; Yoshikazu Yuki; Yoshifumi Takeda; Hiroshi Kiyono
Nontoxic Shiga toxin derivatives from Escherichia coli possess adjuvant activity for the augmentation of antigen-specific immune responses via dendritic cell activation.
Infection and immunity 2005;73(7):4088-97.
2005: Jun Kunisawa; Hiroshi Kiyono
A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense.
Cellular and molecular life sciences : CMLS 2005;62(12):1308-21.
2005: Ayako Hino; Satoshi Fukuyama; Kosuke Kataoka; Mi-Na Kweon; Kohtaro Fujihashi; Hiroshi Kiyono
Nasal IL-12p70 DNA prevents and treats intestinal allergic diarrhea.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):7423-32.
2005: Masafumi Yamamoto; Hiroshi Kiyono
[Host defence mechanisms offered by the mucosal immune system].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 4():447-53.
2005: Tomonori Nochi; Hiroshi Kiyono
[Mucosal immunology].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 4():14-9.
2005: Yasuyuki Kai; Ichiro Takahashi; Hiromichi Ishikawa; Takachika Hiroi; Tsunekazu Mizushima; Chu Matsuda; Daisuke Kishi; Hiromasa Hamada; Hiroshi Tamagawa; Toshinori Ito; Kazuyuki Yoshizaki; Tadamitsu Kishimoto; Hikaru Matsuda; Hiroshi Kiyono
Colitis in mice lacking the common cytokine receptor gamma chain is mediated by IL-6-producing CD4+ T cells.
Gastroenterology 2005;128(4):922-34.
2005: Mi-Na Kweon; Masafumi Yamamoto; Paul D Rennert; Eun Jeong Park; Ah-Young Lee; Sun-Young Chang; Takachika Hiroi; Masanobu Nanno; Hiroshi Kiyono
Prenatal blockage of lymphotoxin beta receptor and TNF receptor p55 signaling cascade resulted in the acceleration of tissue genesis for isolated lymphoid follicles in the large intestine.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):4365-72.
2005: Ryoki Kobayashi; Tomoko Kohda; Kosuke Kataoka; Hideshi Ihara; Shunji Kozaki; David W Pascual; Herman F Staats; Hiroshi Kiyono; Jerry R McGhee; Kohtaro Fujihashi
A novel neurotoxoid vaccine prevents mucosal botulism.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):2190-5.
2005: Satoshi Nonaka; Tomoaki Naito; Hao Chen; Masafumi Yamamoto; Kazuyo Moro; Hiroshi Kiyono; Hiromasa Hamada; Hiromichi Ishikawa
Intestinal gamma delta T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):1906-12.
2004: Naoto Yoshino; Fabien X-S Lü; Kohtaro Fujihashi; Yukari Hagiwara; Kosuke Kataoka; Ding Lu; Linda Hirst; Mitsuo Honda; Frederik W van Ginkel; Yoshifumi Takeda; Christopher J Miller; Hiroshi Kiyono; Jerry R McGhee
A novel adjuvant for mucosal immunity to HIV-1 gp120 in nonhuman primates.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):6850-7.
2004: Tomonori Nochi; Yoshikazu Yuki; Kazutaka Terahara; Ayako Hino; Jun Kunisawa; Mi-Na Kweon; Takahiro Yamaguchi; Hiroshi Kiyono
Biological role of Ep-CAM in the physical interaction between epithelial cells and lymphocytes in intestinal epithelium.
Clinical immunology (Orlando, Fla.) 2004;113(3):326-39.
2004: Mari Ohmura-Hoshino; Masafumi Yamamoto; Yoshikazu Yuki; Yoshifumi Takeda; Hiroshi Kiyono
Non-toxic Stx derivatives from Escherichia coli possess adjuvant activity for mucosal immunity.
Vaccine 2004;22(27-28):3751-61.
2004: Hiroshi Kiyono; Satoshi Fukuyama
NALT- versus Peyer's-patch-mediated mucosal immunity.
Nature reviews. Immunology 2004;4(9):699-710.
2004: Mayumi Ueta; Tomonori Nochi; Myoung Ho Jang; Eun Jeong Park; Osamu Igarashi; Ayako Hino; Satoshi Kawasaki; Takashi Shikina; Takachika Hiroi; Shigeru Kinoshita; Hiroshi Kiyono
Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):3337-47.
2004: Masafumi Yamamoto; Mi-Na Kweon; Paul D Rennert; Takachika Hiroi; Kohtaro Fujihashi; Jerry R McGhee; Hiroshi Kiyono
Role of gut-associated lymphoreticular tissues in antigen-specific intestinal IgA immunity.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):762-9.
2004: Takashi Shikina; Takachika Hiroi; Kouichi Iwatani; Myoung Ho Jang; Satoshi Fukuyama; Manabu Tamura; Takeshi Kubo; Hiromichi Ishikawa; Hiroshi Kiyono
IgA class switch occurs in the organized nasopharynx- and gut-associated lymphoid tissue, but not in the diffuse lamina propria of airways and gut.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6259-64.
2004: Tsunekazu Mizushima; Toshinori Ito; Daisuke Kishi; Yasuyuki Kai; Hiroshi Tamagawa; Riichiro Nezu; Hiroshi Kiyono; Hikaru Matsuda
Therapeutic effects of a new lymphocyte homing reagent FTY720 in interleukin-10 gene-deficient mice with colitis.
Inflammatory bowel diseases 2004;10(3):182-92.
2004: Myoung Ho Jang; Mi-Na Kweon; Kouichi Iwatani; Masafumi Yamamoto; Kazutaka Terahara; Chihiro Sasakawa; Toshihiko Suzuki; Tomonori Nochi; Yoshifumi Yokota; Paul D Rennert; Takachika Hiroi; Hiroshi Tamagawa; Hideki Iijima; Jun Kunisawa; Yoshikazu Yuki; Hiroshi Kiyono
Intestinal villous M cells: an antigen entry site in the mucosal epithelium.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):6110-5.
2004: Ayako Hino; Mi-Na Kweon; Kohtaro Fujihashi; Jerry R McGhee; Hiroshi Kiyono
Pathological role of large intestinal IL-12p40 for the induction of Th2-type allergic diarrhea.
The American journal of pathology 2004;164(4):1327-35.
2003: Eun Jeong Park; Ichiro Takahashi; Junko Ikeda; Kazuko Kawahara; Tetsuji Okamoto; Mi-Na Kweon; Satoshi Fukuyama; Veronika Groh; Thomas Spies; Yuichi Obata; Jun-Ichi Miyazaki; Hiroshi Kiyono
Clonal expansion of double-positive intraepithelial lymphocytes by MHC class I-related chain A expressed in mouse small intestinal epithelium.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4131-9.
2003: Yoshikazu Yuki; Hiroshi Kiyono
New generation of mucosal adjuvants for the induction of protective immunity.
Reviews in medical virology 2003;13(5):293-310.
2003: Hiroshi Tamagawa; Ichiro Takahashi; Mikio Furuse; Yuka Yoshitake-Kitano; Shoichiro Tsukita; Toshinori Ito; Hikaru Matsuda; Hiroshi Kiyono
Characteristics of claudin expression in follicle-associated epithelium of Peyer's patches: preferential localization of claudin-4 at the apex of the dome region.
Laboratory investigation; a journal of technical methods and pathology 2003;83(7):1045-53.
2003: Masaya Kobayashi; Mi-Na Kweon; Hirotaka Kuwata; Robert D Schreiber; Hiroshi Kiyono; Kiyoshi Takeda; Shizuo Akira
Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice.
The Journal of clinical investigation 2003;111(9):1297-308.
2003: Myoung Ho Jang; Mi-Na Kweon; Takachika Hiroi; Masafumi Yamamoto; Ichiro Takahashi; Hiroshi Kiyono
Induction of cytotoxic T lymphocyte responses by cholera toxin-treated bone marrow-derived dendritic cells.
Vaccine 2003;21(15):1613-9.
2003: Yukari Hagiwara; Jerry R McGhee; Kohtaro Fujihashi; Ryoki Kobayashi; Naoto Yoshino; Kosuke Kataoka; Yuri Etani; Mi-Na Kweon; Shinichi Tamura; Takeshi Kurata; Yoshifumi Takeda; Hiroshi Kiyono; Kohtaro Fujihashi
Protective mucosal immunity in aging is associated with functional CD4+ T cells in nasopharyngeal-associated lymphoreticular tissue.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):1754-62.
2003: Mi-Na Kweon; Hiroshi Kiyono
Eosinophilic gastroenteritis: a problem of the mucosal immune system?
Current allergy and asthma reports 2003;3(1):79-85.
2003: Yoshiko Okuda; Ichiro Takahashi; Jin-Kyung Kim; Noriyuki Ohta; Kouichi Iwatani; Hideki Iijima; Yasuyuki Kai; Hiroshi Tamagawa; Takachika Hiroi; Mi-Na Kweon; Sunao Kawano; Kiyoshi Takeda; Sizuo Akira; Yutaka Sasaki; Masatsugu Hori; Hiroshi Kiyono
Development of colitis in signal transducers and activators of transcription 6-deficient T-cell receptor alpha-deficient mice: a potential role of signal transducers and activators of transcription 6-independent interleukin-4 signaling for the generation of Th2-biased pathological CD4+ betabetaT cells.
The American journal of pathology 2003;162(1):263-71.
2003: Gaku Sakaue; Takachika Hiroi; Yoko Nakagawa; Kenji Someya; Kouichi Iwatani; Yoshiki Sawa; Hidemi Takahashi; Mitsuo Honda; Jun Kunisawa; Hiroshi Kiyono
HIV mucosal vaccine: nasal immunization with gp160-encapsulated hemagglutinating virus of Japan-liposome induces antigen-specific CTLs and neutralizing antibody responses.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):495-502.
2003: Prosper N Boyaka; Mari Ohmura; Kohtaro Fujihashi; Toshiya Koga; Masafumi Yamamoto; Mi-Na Kweon; Yoshifumi Takeda; Raymond J Jackson; Hiroshi Kiyono; Yoshikazu Yuki; Jerry R McGhee
Chimeras of labile toxin one and cholera toxin retain mucosal adjuvanticity and direct Th cell subsets via their B subunit.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):454-62.
2002: Mamoru Kawahara; Kazuhiro Matsuo; Tadashi Nakasone; Takachika Hiroi; Hiroshi Kiyono; Sohkichi Matsumoto; Takeshi Yamada; Naoki Yamamoto; Mitsuo Honda
Combined intrarectal/intradermal inoculation of recombinant Mycobacterium bovis bacillus Calmette-Guérin (BCG) induces enhanced immune responses against the inserted HIV-1 V3 antigen.
Vaccine 2002;21(3-4):158-66.
2002: Naotoshi Kinoshita; Takachika Hiroi; Noriyuki Ohta; Satoshi Fukuyama; Eun Jeong Park; Hiroshi Kiyono
Autocrine IL-15 mediates intestinal epithelial cell death via the activation of neighboring intraepithelial NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(11):6187-92.
2002: Mi-Na Kweon; Masafumi Yamamoto; Fumiko Watanabe; Shinichi Tamura; Frederik W van Ginkel; Akira Miyauchi; Hiroaki Takagi; Yoshifumi Takeda; Takashi Hamabata; Kohtaro Fujihashi; Jerry R McGhee; Hiroshi Kiyono
A nontoxic chimeric enterotoxin adjuvant induces protective immunity in both mucosal and systemic compartments with reduced IgE antibodies.
The Journal of infectious diseases 2002;186(9):1261-9.
2002: Izumi Watanabe; Yukari Hagiwara; Shin-etsu Kadowaki; Tomoki Yoshikawa; Katsuhiro Komase; Chikara Aizawa; Hiroshi Kiyono; Yoshifumi Takeda; Jerry R McGhee; Joe Chiba; Tetsutaro Sata; Takeshi Kurata; Shin-ichi Tamura
Characterization of protective immune responses induced by nasal influenza vaccine containing mutant cholera toxin as a safe adjuvant (CT112K).
Vaccine 2002;20(29-30):3443-55.
2002: Masahiko Yanagita; Yoshio Shimabukuro; Takenori Nozaki; Naoko Yoshimura; Junko Watanabe; Hiroko Koide; Mami Terakura; Teruyuki Saho; Masahide Takedachi; Myoung Ho Jang; Hiroshi Kiyono; Shinya Murakami
IL-15 up-regulates iNOS expression and NO production by gingival epithelial cells.
Biochemical and biophysical research communications 2002;297(2):329-34.
2002: Jun Kunisawa; Ichiro Takahashi; Akiko Okudaira; Takachika Hiroi; Kazufumi Katayama; Teruko Ariyama; Yasuo Tsutsumi; Shinsaku Nakagawa; Hiroshi Kiyono; Tadanori Mayumi
Lack of antigen-specific immune responses in anti-IL-7 receptor alpha chain antibody-treated Peyer's patch-null mice following intestinal immunization with microencapsulated antigen.
European journal of immunology 2002;32(8):2347-55.
2002: Noriko Suenobu; Mi-Na Kweon; Hiroshi Kiyono
Nasal vaccination induces the ability to eliminate Candida colonization without influencing the pre-existing antigen-specific IgE Abs: a possibility for the control of Candida-related atopic dermatitis.
Vaccine 2002;20(23-24):2972-80.
2002: Satoshi Fukuyama; Takachika Hiroi; Yoshifumi Yokota; Paul D Rennert; Masahiko Yanagita; Naotoshi Kinoshita; Seigo Terawaki; Takashi Shikina; Masafumi Yamamoto; Yuichi Kurono; Hiroshi Kiyono
Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells.
Immunity 2002;17(1):31-40.
2002: Noriyuki Ohta; Takachika Hiroi; Mi-Na Kweon; Naotoshi Kinoshita; Myoung Ho Jang; Tadashi Mashimo; Jun-Ichi Miyazaki; Hiroshi Kiyono
IL-15-dependent activation-induced cell death-resistant Th1 type CD8 alpha beta+NK1.1+ T cells for the development of small intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):460-8.
2002: Ichiro Takahashi; Jennifer L Matsuda; Laurent Gapin; Hilde DeWinter; Yasuyuki Kai; Hiroshi Tamagawa; Mitchell Kronenberg; Hiroshi Kiyono
Colitis-related public T cells are selected in the colonic lamina propria of IL-10-deficient mice.
Clinical immunology (Orlando, Fla.) 2002;102(3):237-48.
2002: Mi-Na Kweon; Ichiro Takahashi; Masafumi Yamamoto; Myoung Ho Jang; N Suenobu; Hiroshi Kiyono
Development of antigen induced colitis in SCID mice reconstituted with spleen derived memory type CD4(+) CD45RB(+) T cells.
Gut 2002;50(3):299-306.
2002: Mi-Na Kweon; Hiroshi Kiyono
CD40L in autoimmunity and mucosally induced tolerance.
The Journal of clinical investigation 2002;109(2):171-3.
2002: Hiromasa Hamada; Takachika Hiroi; Yasuhiro Nishiyama; Hidemi Takahashi; Yohei Masunaga; Satoshi Hachimura; Shuichi Kaminogawa; Hiromi Takahashi-Iwanaga; Toshihiko Iwanaga; Hiroshi Kiyono; Hiroshi Yamamoto; Hiromichi Ishikawa
Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):57-64.
2001: Takachika Hiroi; H Goto; K Someya; Masahiko Yanagita; M Honda; N Yamanaka; Hiroshi Kiyono
HIV mucosal vaccine: nasal immunization with rBCG-V3J1 induces a long term V3J1 peptide-specific neutralizing immunity in Th1- and Th2-deficient conditions.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5862-7.
2001: M Yura; Ichiro Takahashi; S Terawaki; Takachika Hiroi; Mi-Na Kweon; Yoshikazu Yuki; Hiroshi Kiyono
Nasal administration of cholera toxin (CT) suppresses clinical signs of experimental autoimmune encephalomyelitis (EAE).
Vaccine 2001;20(1-2):134-9.
2001: Kohtaro Fujihashi; Hirotomo Kato; Frederik W van Ginkel; Toshiya Koga; Prosper N Boyaka; Raymond J Jackson; Rie Kato; Yukari Hagiwara; Yuri Etani; I Goma; K Fujihashi; Hiroshi Kiyono; Jerry R McGhee
A revisit of mucosal IgA immunity and oral tolerance.
Acta odontologica Scandinavica 2001;59(5):301-8.
2001: J K Kim; Ichiro Takahashi; Y Kai; Hiroshi Kiyono
Influence of enterotoxin on mucosal intranet: selective inhibition of extrathymic T cell development in intestinal intraepithelial lymphocytes by oral exposure to heat-labile toxin.
European journal of immunology 2001;31(10):2960-9.
2001: Taeko Dohi; Paul D Rennert; Kohtaro Fujihashi; Hiroshi Kiyono; Y Shirai; Yuki I Kawamura; Jeffrey L Browning; Jerry R McGhee
Elimination of colonic patches with lymphotoxin beta receptor-Ig prevents Th2 cell-type colitis.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2781-90.
2001: M Yura; Ichiro Takahashi; M Serada; T Koshio; K Nakagami; Yoshikazu Yuki; Hiroshi Kiyono
Role of MOG-stimulated Th1 type "light up" (GFP+) CD4+ T cells for the development of experimental autoimmune encephalomyelitis (EAE).
Journal of autoimmunity 2001;17(1):17-25.
2001: Jun Kunisawa; Tsuyoshi Nakanishi; Ichiro Takahashi; Akiko Okudaira; Yasuo Tsutsumi; Kazufumi Katayama; Shinsaku Nakagawa; Hiroshi Kiyono; Tadanori Mayumi
Sendai virus fusion protein mediates simultaneous induction of MHC class I/II-dependent mucosal and systemic immune responses via the nasopharyngeal-associated lymphoreticular tissue immune system.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1406-12.
2001: Gaku Sakaue; M Shimaoka; T Fukuoka; Takachika Hiroi; Tetsu Inoue; Nobuo Hashimoto; T Sakaguchi; Yoshiki Sawa; R Morishita; Hiroshi Kiyono; K Noguchi; Takashi Mashimo
NF-kappa B decoy suppresses cytokine expression and thermal hyperalgesia in a rat neuropathic pain model.
Neuroreport 2001;12(10):2079-84.
2001: Yoshikazu Yuki; Y Byun; M Fujita; W Izutani; T Suzuki; Shigezo Udaka; Kohtaro Fujihashi; Jerry R McGhee; Hiroshi Kiyono
Production of a recombinant hybrid molecule of cholera toxin-B-subunit and proteolipid-protein-peptide for the treatment of experimental encephalomyelitis.
Biotechnology and bioengineering 2001;74(1):62-9.
2001: J K Kim; Ichiro Takahashi; Y Okuda; M Itakura; Jerry R McGhee; Hiroshi Kiyono
T cell receptor dynamism of mucosal and systemic CD4+ T cells in the course of an immune response to Escherichia coli heat-labile enterotoxin.
The Journal of infectious diseases 2001;184(1):43-51.
2001: M Shimizu; K Minakuchi; A Tsuda; T Hiroi; N Tanaka; Junichi Koga; Hiroshi Kiyono
Role of stem cell factor and c-kit signaling in regulation of fetal intestinal epithelial cell adhesion to fibronectin.
Experimental cell research 2001;266(2):311-22.
2001: Hiroshi Kiyono; Mi-Na Kweon; Takachika Hiroi; Ichiro Takahashi
The mucosal immune system: from specialized immune defense to inflammation and allergy.
Acta odontologica Scandinavica 2001;59(3):145-53.
2001: N Ohta; M Shimaoka; Hideaki Imanaka; Masaji Nishimura; Nobuyuki Taenaka; Hiroshi Kiyono; Ikuto Yoshiya
Glucocorticoid suppresses neutrophil activation in ventilator-induced lung injury.
Critical care medicine 2001;29(5):1012-6.
2001: Kohtaro Fujihashi; Taeko Dohi; Paul D Rennert; M Yamamoto; T Koga; Hiroshi Kiyono; Jerry R McGhee
Peyer's patches are required for oral tolerance to proteins.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3310-5.
2001: Hideki Iijima; Ichiro Takahashi; Hiroshi Kiyono
Mucosal immune network in the gut for the control of infectious diseases.
Reviews in medical virology 2001;11(2):117-33.
2001: Masato Yamamoto; Jerry R McGhee; Y Hagiwara; S Otake; Hiroshi Kiyono
Genetically manipulated bacterial toxin as a new generation mucosal adjuvant.
Scandinavian journal of immunology 2001;53(3):211-7.
2001: M Saito; S Otake; M Ohmura; M Hirasawa; K Takada; J Mega; I Takahashi; Hiroshi Kiyono; Jerry R McGhee; Yoshifumi Takeda; Masato Yamamoto
Protective immunity to Streptococcus mutans induced by nasal vaccination with surface protein antigen and mutant cholera toxin adjuvant.
The Journal of infectious diseases 2001;183(5):823-6.
2001: Y Byun; Mari Ohmura; Kohtaro Fujihashi; S Yamamoto; Jerry R McGhee; Shigezo Udaka; Hiroshi Kiyono; Yoshifumi Takeda; T Kohsaka; Yoshikazu Yuki
Nasal immunization with E. coli verotoxin 1 (VT1)-B subunit and a nontoxic mutant of cholera toxin elicits serum neutralizing antibodies.
Vaccine 2001;19(15-16):2061-70.
2001: Hiroshi Kiyono
Mucosal immune system: close encounter in the uncharted world of immunology.
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde 2001;215 Suppl 1():22-32.
2000: Jun Kunisawa; Gaku Sakaue; Hiroshi Kiyono
[NALT immune system for the development of AIDS mucosal vaccine].
Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology 2000;23(6):579-81.
2000: Prosper N Boyaka; Peter F Wright; M Marinaro; Hiroshi Kiyono; Joyce E Johnson; Ricardo A Gonzales; Mine R Ikizler; Jay A Werkhaven; Raymond J Jackson; Kohtaro Fujihashi; S Di Fabio; Herman F Staats; Jerry R McGhee
Human nasopharyngeal-associated lymphoreticular tissues. Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils.
The American journal of pathology 2000;157(6):2023-35.
2000: Daisuke Kishi; Ichiro Takahashi; Yasuyuki Kai; Hiroshi Tamagawa; Hideki Iijima; S Obunai; Riichiro Nezu; Takashi Ito; Hikaru Matsuda; Hiroshi Kiyono
Alteration of V beta usage and cytokine production of CD4+ TCR beta beta homodimer T cells by elimination of Bacteroides vulgatus prevents colitis in TCR alpha-chain-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5891-9.
2000: Toshiya Koga; Jerry R McGhee; H Kato; R Kato; Hiroshi Kiyono; Kohtaro Fujihashi
Evidence for early aging in the mucosal immune system.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):5352-9.
2000: Takachika Hiroi; Masahiko Yanagita; Noriyuki Ohta; Gaku Sakaue; Hiroshi Kiyono
IL-15 and IL-15 receptor selectively regulate differentiation of common mucosal immune system-independent B-1 cells for IgA responses.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(8):4329-37.
2000: Jun Kunisawa; Akiko Okudaira; Y Tsutusmi; Ichiro Takahashi; Tsuyoshi Nakanishi; Hiroshi Kiyono; Tadanori Mayumi
Characterization of mucoadhesive microspheres for the induction of mucosal and systemic immune responses.
Vaccine 2000;19(4-5):589-94.
2000: Taeko Dohi; Kohtaro Fujihashi; Hiroshi Kiyono; Charles O Elson; Jerry R McGhee
Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis.
Gastroenterology 2000;119(3):724-33.
2000: Mi-Na Kweon; Masafumi Yamamoto; M Kajiki; Ichiro Takahashi; Hiroshi Kiyono
Systemically derived large intestinal CD4(+) Th2 cells play a central role in STAT6-mediated allergic diarrhea.
The Journal of clinical investigation 2000;106(2):199-206.
2000: Masato Yamamoto; Hiroshi Kiyono; MN Kweon; S Yamamoto; Kohtaro Fujihashi; H Kurazono; K Imaoka; H Bluethmann; I Takahashi; Yoshifumi Takeda; M Azuma; Jerry R McGhee
Enterotoxin adjuvants have direct effects on T cells and antigen-presenting cells that result in either interleukin-4-dependent or -independent immune responses.
The Journal of infectious diseases 2000;182(1):180-90.
2000: Masato Yamamoto; Paul D Rennert; Jerry R McGhee; MN Kweon; S Yamamoto; Taeko Dohi; S Otake; H Bluethmann; Kohtaro Fujihashi; Hiroshi Kiyono
Alternate mucosal immune system: organized Peyer's patches are not required for IgA responses in the gastrointestinal tract.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(10):5184-91.
2000: W Saitoh-Inagawa; Takachika Hiroi; Masahiko Yanagita; Hideki Iijima; Eiichi Uchio; Shigeaki Ohno; K Aoki; Hiroshi Kiyono
Unique characteristics of lacrimal glands as a part of mucosal immune network: high frequency of IgA-committed B-1 cells and NK1.1+ alphabeta T cells.
Investigative ophthalmology & visual science 2000;41(1):138-44.
1999: Kohtaro Fujihashi; Taeko Dohi; Mi-Na Kweon; Jerry R McGhee; Toshiya Koga; Max D Cooper; Susumu Tonegawa; Hiroshi Kiyono
gammadelta T cells regulate mucosally induced tolerance in a dose-dependent fashion.
International immunology 1999;11(12):1907-16.
1999: David W Pascual; David Hone; S Hall; Frederik W van Ginkel; M Yamamoto; Nancy Walters; Kohtaro Fujihashi; R J Powell; Shaoguang Wu; John L VanCott; Hiroshi Kiyono; Jerry R McGhee
Expression of recombinant enterotoxigenic Escherichia coli colonization factor antigen I by Salmonella typhimurium elicits a biphasic T helper cell response.
Infection and immunity 1999;67(12):6249-56.
1999: Masayuki Tori; Takashi Ito; Takeyoshi Yumiba; A Okawa; Akira Maeda; T Sawai; Tetsuma Kiyomoto; Yusuke Akamaru; Masayuki Miyasaka; Hiroshi Kiyono; Hikaru Matsuda; Masumi Nozawa; Ryota Shirakura
Proliferation of donor-derived NKR-P1+TCR alpha beta + (NKT) cells in the nonrecurrent spontaneous diabetic BB rats transplanted with pancreaticoduodenal grafts of Wistar-Furth donors.
Transplantation proceedings 1999;31(7):2741-2.
1999: Hideki Iijima; Ichiro Takahashi; Daisuke Kishi; J K Kim; S Kawano; Masatsugu Hori; Hiroshi Kiyono
Alteration of interleukin 4 production results in the inhibition of T helper type 2 cell-dominated inflammatory bowel disease in T cell receptor alpha chain-deficient mice.
The Journal of experimental medicine 1999;190(5):607-15.
1999: Frederik W van Ginkel; S M Wahl; John F Kearney; Mi-Na Kweon; Kohtaro Fujihashi; P D Burrows; Hiroshi Kiyono; Jerry R McGhee
Partial IgA-deficiency with increased Th2-type cytokines in TGF-beta 1 knockout mice.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):1951-7.
1999: Masayuki Tori; Takashi Ito; Takeyoshi Yumiba; Atsushi Ohkawa; Akira Maeda; T Sawai; Tetsuma Kiyomoto; Yusuke Akamaru; Masayuki Miyasaka; Hiroshi Kiyono; Hikaru Matsuda; Masumi Nozawa; Ryota Shirakura
IL-4 production in IDDM-nonrecurrent pancreas-transplanted BB rats with donor-derived NKR-P1+TCR alpha beta + (NKT) cells, but not in IDDM-recurrent BB rats.
Transplantation proceedings 1999;31(5):1940-1.
1999: Masato Yamamoto; Hiroshi Kiyono; S Yamamoto; E Batanero; MN Kweon; S Otake; M Azuma; Yoshifumi Takeda; Jerry R McGhee
Direct effects on antigen-presenting cells and T lymphocytes explain the adjuvanticity of a nontoxic cholera toxin mutant.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7015-21.
1999: Jerry R McGhee; Hiroshi Kiyono; M Kubota; S Kawabata; Christopher J Miller; T Lehner; K Imaoka; Kohtaro Fujihashi
Mucosal Th1- versus Th2-type responses for antibody- or cell-mediated immunity to simian immunodeficiency virus in rhesus macaques.
The Journal of infectious diseases 1999;179 Suppl 3():S480-4.
1999: Taeko Dohi; Kohtaro Fujihashi; Paul D Rennert; Kouichi Iwatani; Hiroshi Kiyono; Jerry R McGhee
Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses.
The Journal of experimental medicine 1999;189(8):1169-80.
1999: Prosper N Boyaka; M Marinaro; John L VanCott; I Takahashi; Kohtaro Fujihashi; Masato Yamamoto; Frederik W van Ginkel; Raymond J Jackson; Hiroshi Kiyono; Jerry R McGhee
Strategies for mucosal vaccine development.
The American journal of tropical medicine and hygiene 1999;60(4 Suppl):35-45.
1999: Masahiko Yanagita; Takachika Hiroi; N Kitagaki; Shigeyuki Hamada; Hiroaki Ito; H Shimauchi; Shinya Murakami; Hiroshi Okada; Hiroshi Kiyono
Nasopharyngeal-associated lymphoreticular tissue (NALT) immunity: fimbriae-specific Th1 and Th2 cell-regulated IgA responses for the inhibition of bacterial attachment to epithelial cells and subsequent inflammatory cytokine production.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3559-65.
1999: Masafumi Yamamoto; Hiroshi Kiyono
Immunoregulatory functions of mucosal gammadelta T cells.
Microbes and infection / Institut Pasteur 1999;1(3):241-6.
1999: Mi-Na Kweon; Kohtaro Fujihashi; Y Wakatsuki; Toshiya Koga; M Yamamoto; Jerry R McGhee; Hiroshi Kiyono
Mucosally induced systemic T cell unresponsiveness to ovalbumin requires CD40 ligand-CD40 interactions.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):1904-9.
1999: Ichiro Takahashi; Hideki Iijima; R Katashima; M Itakura; Hiroshi Kiyono
Clonal expansion of CD4+ TCRbetabeta+ T cells in TCR alpha-chain- deficient mice by gut-derived antigens.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1843-50.
1999: Huan Nguyen; Zina Moldoveanu; Miroslav J Novak; Frederik W van Ginkel; EM Ban; Hiroshi Kiyono; Jerry R McGhee; Jiri Mestecky
Heterosubtypic immunity to lethal influenza A virus infection is associated with virus-specific CD8(+) cytotoxic T lymphocyte responses induced in mucosa-associated tissues.
Virology 1999;254(1):50-60.
1999: Takachika Hiroi; Masahiko Yanagita; Hideki Iijima; Kouichi Iwatani; Toshimi Yoshida; K Takatsu; Hiroshi Kiyono
Deficiency of IL-5 receptor alpha-chain selectively influences the development of the common mucosal immune system independent IgA-producing B-1 cell in mucosa-associated tissues.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):821-8.
1999: Ichiro Takahashi; H Lijima; Daisuke Kishi; Hiroshi Kiyono
Oligoclonal Th2-biased betabeta T cells induce murine inflammatory bowel disease.
Immunologic research 1999;20(3):237-42.
1999: Masayuki Tori; Takashi Ito; Takeyoshi Yumiba; Akira Maeda; T Sawai; Masayuki Miyasaka; Hiroshi Kiyono; Hikaru Matsuda; Masumi Nozawa; Ryota Shirakura
Significant role of intragraft lymphoid tissues in preventing insulin-dependent diabetes mellitus recurrence in whole pancreaticoduodenal transplantation.
Microsurgery 1999;19(7):338-43.
1999: Masahiro Sugimoto; M Shimaoka; Nobuyuki Taenaka; Hiroshi Kiyono; Ikuto Yoshiya
Lymphocyte activation is attenuated by stellate ganglion block.
Regional anesthesia and pain medicine 1999;24(1):30-5.
1999: Prosper N Boyaka; M Marinaro; Raymond J Jackson; S Menon; Hiroshi Kiyono; Emilio Jirillo; Jerry R McGhee
IL-12 is an effective adjuvant for induction of mucosal immunity.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):122-8.
1999: M Marinaro; Prosper N Boyaka; Raymond J Jackson; Fred D Finkelman; Hiroshi Kiyono; Emilio Jirillo; Jerry R McGhee
Use of intranasal IL-12 to target predominantly Th1 responses to nasal and Th2 responses to oral vaccines given with cholera toxin.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):114-21.
1998: T Kobayashi; Masato Yamamoto; T Hiroi; J McGhee; Y Takeshita; Hiroshi Kiyono
Arginine enhances induction of T helper 1 and T helper 2 cytokine synthesis by Peyer's patch alpha beta T cells and antigen-specific mucosal immune response.
Bioscience, biotechnology, and biochemistry 1998;62(12):2334-40.
1998: M Shimaoka; K Hosotsubo; M Sugimoto; Gaku Sakaue; Nobuyuki Taenaka; Ikuto Yoshiya; Hiroshi Kiyono
The influence of surgical stress on T cells: enhancement of early phase lymphocyte activation.
Anesthesia and analgesia 1998;87(6):1431-5.
1998: K Imaoka; Christopher J Miller; M Kubota; Michael B McChesney; B Lohman; Masato Yamamoto; Kohtaro Fujihashi; K Someya; M Honda; Jerry R McGhee; Hiroshi Kiyono
Nasal immunization of nonhuman primates with simian immunodeficiency virus p55gag and cholera toxin adjuvant induces Th1/Th2 help for virus-specific immune responses in reproductive tissues.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):5952-8.
1998: John L VanCott; S N Chatfield; M Roberts; David Hone; E L Hohmann; David W Pascual; M Yamamoto; Hiroshi Kiyono; Jerry R McGhee
Regulation of host immune responses by modification of Salmonella virulence genes.
Nature medicine 1998;4(11):1247-52.
1998: Hideki Iijima; Ichiro Takahashi; Takachika Hiroi; M Shimaoka; Sunao Kawano; K Nagano; Masatsugu Hori; Hiroshi Kiyono
Orally administered cholera toxin prevents murine intestinal T cells from staphylococcal enterotoxin B-induced anergy.
Gastroenterology 1998;115(5):1197-204.
1998: Paul R Harris; Peter B Ernst; S Kawabata; Hiroshi Kiyono; Martin F Graham; Phillip D Smith
Recombinant Helicobacter pylori urease activates primary mucosal macrophages.
The Journal of infectious diseases 1998;178(5):1516-20.
1998: Masato Yamamoto; D E Briles; S Yamamoto; M Ohmura; Hiroshi Kiyono; Jerry R McGhee
A nontoxic adjuvant for mucosal immunity to pneumococcal surface protein A.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(8):4115-21.
1998: Motoyuki Itoh; Katsuhiko Ishihara; Takachika Hiroi; B O Lee; H Maeda; Hideki Iijima; Masahiko Yanagita; Hiroshi Kiyono; Toshio Hirano
Deletion of bone marrow stromal cell antigen-1 (CD157) gene impaired systemic thymus independent-2 antigen-induced IgG3 and mucosal TD antigen-elicited IgA responses.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(8):3974-83.
1998: M Marinaro; Prosper N Boyaka; Hiroshi Kiyono; Jerry R McGhee
Novel approaches for the induction of T helper 1 (Th1)- or Th2-type mucosal and parenteral immune responses.
Expert opinion on investigational drugs 1998;7(10):1657-66.
1998: Takachika Hiroi; Kouichi Iwatani; Hideki Iijima; S Kodama; Masahiko Yanagita; Hiroshi Kiyono
Nasal immune system: distinctive Th0 and Th1/Th2 type environments in murine nasal-associated lymphoid tissues and nasal passage, respectively.
European journal of immunology 1998;28(10):3346-53.
1998: S Kawabata; Prosper N Boyaka; M Coste; Kohtaro Fujihashi; Masato Yamamoto; Jerry R McGhee; Hiroshi Kiyono
Intraepithelial lymphocytes from villus tip and crypt portions of the murine small intestine show distinct characteristics.
Gastroenterology 1998;115(4):866-73.
1998: Huan Nguyen; Prosper N Boyaka; Zina Moldoveanu; Miroslav J Novak; Hiroshi Kiyono; Jerry R McGhee; Jiri Mestecky
Influenza virus-infected epithelial cells present viral antigens to antigen-specific CD8+ cytotoxic T lymphocytes.
Journal of virology 1998;72(5):4534-6.
1998: Yoshikazu Yuki; Kohtaro Fujihashi; Masato Yamamoto; Jerry R McGhee; Hiroshi Kiyono
Human milk proteins including secretory IgA fail to elicit tolerance after feeding.
International immunology 1998;10(4):537-45.
1998: M Sugimoto; M Shimaoka; K Hosotsubo; H Tanigami; Nobuyuki Taenaka; Hiroshi Kiyono; Ikuto Yoshiya
Up-regulation of Fas ligand (FasL) mRNA expression in peripheral blood mononuclear cells (PBMC) after major surgery.
Clinical and experimental immunology 1998;112(1):120-5.
1998: Masato Yamamoto; Kohtaro Fujihashi; K Kawabata; Jerry R McGhee; Hiroshi Kiyono
A mucosal intranet: intestinal epithelial cells down-regulate intraepithelial, but not peripheral, T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(5):2188-96.
1998: Mi-Na Kweon; Kohtaro Fujihashi; John L VanCott; K Higuchi; Masato Yamamoto; Jerry R McGhee; Hiroshi Kiyono
Lack of orally induced systemic unresponsiveness in IFN-gamma knockout mice.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(4):1687-93.
1998: S Kawabata; Christopher J Miller; T Lehner; Kohtaro Fujihashi; M Kubota; Jerry R McGhee; K Imaoka; T Hiroi; Hiroshi Kiyono
Induction of Th2 cytokine expression for p27-specific IgA B cell responses after targeted lymph node immunization with simian immunodeficiency virus antigens in rhesus macaques.
The Journal of infectious diseases 1998;177(1):26-33.
1997: S Kawabata; Prosper N Boyaka; M Coste; Kohtaro Fujihashi; S Hamada; Jerry R McGhee; Hiroshi Kiyono
A novel alkaline phosphatase-based isolation method allows characterization of intraepithelial lymphocytes from villi tip and crypt regions of murine small intestine.
Biochemical and biophysical research communications 1997;241(3):797-802.
1997: K Yamada; M Shimaoka; K Nagayama; Takachika Hiroi; Hiroshi Kiyono; T Honda
Bacterial invasion induces interleukin-7 receptor expression in colonic epithelial cell line, T84.
European journal of immunology 1997;27(12):3456-60.
1997: David W Pascual; M Coste; Prosper N Boyaka; Hiroshi Kiyono; Jerry R McGhee
Spontaneously hypertensive rat: cholera toxin converts suppression to immunity through a Th2 cell-IL-4 pathway.
The American journal of physiology 1997;273(4 Pt 2):R1509-18.
1997: Kohtaro Fujihashi; Jerry R McGhee; Masato Yamamoto; J J Peschon; Hiroshi Kiyono
An interleukin-7 internet for intestinal intraepithelial T cell development: knockout of ligand or receptor reveal differences in the immunodeficient state.
European journal of immunology 1997;27(9):2133-8.
1997: Frederik W van Ginkel; Jerry R McGhee; Cunren Liu; Jerry Simecka; Masato Yamamoto; R A Frizzell; Eric J Sorscher; Hiroshi Kiyono; David W Pascual
Adenoviral gene delivery elicits distinct pulmonary-associated T helper cell responses to the vector and to its transgene.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(2):685-93.
1997: EM Ban; Frederik W van Ginkel; Jerry Simecka; Hiroshi Kiyono; Harriet L Robinson; Jerry R McGhee
Mucosal immunization with DNA encoding influenza hemagglutinin.
Vaccine 1997;15(8):811-3.
1997: M Yamamoto; M N Kweon; Hiroshi Kiyono
[The mechanisms of oral tolerance].
Nihon rinsho. Japanese journal of clinical medicine 1997;55(6):1444-9.
1997: Ichiro Takahashi; Hiroshi Kiyono; S Hamada
CD4+ T-cell population mediates development of inflammatory bowel disease in T-cell receptor alpha chain-deficient mice.
Gastroenterology 1997;112(6):1876-86.
1997: M Kubota; Christopher J Miller; K Imaoka; S Kawabata; Kohtaro Fujihashi; Jerry R McGhee; Hiroshi Kiyono
Oral immunization with simian immunodeficiency virus p55gag and cholera toxin elicits both mucosal IgA and systemic IgG immune responses in nonhuman primates.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(11):5321-9.
1997: S Yamamoto; Hiroshi Kiyono; Masato Yamamoto; K Imaoka; Kohtaro Fujihashi; Frederik W van Ginkel; M Noda; Yoshifumi Takeda; Jerry R McGhee
A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5267-72.
1997: S Yamamoto; Yoshifumi Takeda; Masato Yamamoto; H Kurazono; K Imaoka; M Yamamoto; Kohtaro Fujihashi; M Noda; Hiroshi Kiyono; Jerry R McGhee
Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrheagenicity but retain adjuvanticity.
The Journal of experimental medicine 1997;185(7):1203-10.
1997: M Marinaro; Prosper N Boyaka; Fred D Finkelman; Hiroshi Kiyono; Raymond J Jackson; Emilio Jirillo; Jerry R McGhee
Oral but not parenteral interleukin (IL)-12 redirects T helper 2 (Th2)-type responses to an oral vaccine without altering mucosal IgA responses.
The Journal of experimental medicine 1997;185(3):415-27.
1997: John L VanCott; Mi-Na Kweon; Kohtaro Fujihashi; Masato Yamamoto; M Marinaro; Hiroshi Kiyono; Jerry R McGhee
Helper T subsets and cytokines for mucosal immunity and tolerance.
Behring Institute Mitteilungen 1997;(98):44-52.
1997: Masahiko Yanagita; Takachika Hiroi; Hiroshi Kiyono
[Mucosal immune system and mucosal vaccine].
Nihon rinsho. Japanese journal of clinical medicine 1997;55(2):492-501.
1997: Masato Yamamoto; Larry McDaniel; K Kawabata; David E Briles; Raymond J Jackson; Jerry R McGhee; Hiroshi Kiyono
Oral immunization with PspA elicits protective humoral immunity against Streptococcus pneumoniae infection.
Infection and immunity 1997;65(2):640-4.
1997: Kohtaro Fujihashi; Mi-Na Kweon; Hiroshi Kiyono; John L VanCott; Frederik W van Ginkel; Masato Yamamoto; Jerry R McGhee
A T cell/B cell/epithelial cell internet for mucosal inflammation and immunity.
Springer seminars in immunopathology 1997;18(4):477-94.
1997: Marianne Wallace; Alexander M Scharko; C. David Pauza; Paul Fisch; K Imaoka; S Kawabata; Kohtaro Fujihashi; Hiroshi Kiyono; Y Tanaka; B R Bloom; Miroslav Malkovsky
Functional gamma delta T-lymphocyte defect associated with human immunodeficiency virus infections.
Molecular medicine (Cambridge, Mass.) 1997;3(1):60-71.
1997: Masato Yamamoto; Kohtaro Fujihashi; T Hiroi; Jerry R McGhee; T E Van Dyke; Hiroshi Kiyono
Molecular and cellular mechanisms for periodontal diseases: role of Th1 and Th2 type cytokines in induction of mucosal inflammation.
Journal of periodontal research 1997;32(1 Pt 2):115-9.
1996: M Marinaro; Prosper N Boyaka; Raymond J Jackson; Fred D Finkelman; Hiroshi Kiyono; Jerry R McGhee
Interleukin-12 alters helper T-cell subsets and antibody profiles induced by the mucosal adjuvant cholera toxin.
Annals of the New York Academy of Sciences 1996;795():361-5.
1996: Charles O Elson; Ken Beagley; A T Sharmanov; Kohtaro Fujihashi; Hiroshi Kiyono; G S Tennyson; Yingzi Cong; CA Black; B W Ridwan; Jerry R McGhee
Hapten-induced model of murine inflammatory bowel disease: mucosa immune responses and protection by tolerance.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(5):2174-85.
1996: I Nakagawa; Ichiro Takahashi; Hiroshi Kiyono; J R McGhee; Shigeyuki Hamada
Oral immunization with the B subunit of the heat-labile enterotoxin of Escherichia coli induces early Th1 and late Th2 cytokine expression in Peyer's patches.
The Journal of infectious diseases 1996;173(6):1428-36.
1996: N Okahashi; Masato Yamamoto; John L VanCott; Steven N Chatfield; M Roberts; H Bluethmann; T Hiroi; Hiroshi Kiyono; Jerry R McGhee
Oral immunization of interleukin-4 (IL-4) knockout mice with a recombinant Salmonella strain or cholera toxin reveals that CD4+ Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin A responses.
Infection and immunity 1996;64(5):1516-25.
1996: Raymond J Jackson; Kohtaro Fujihashi; Hiroshi Kiyono; Jerry R McGhee
Luminometry: a novel bioluminescent immunoassay enhances the quantitation of mucosal and systemic antibody responses.
Journal of immunological methods 1996;190(2):189-97.
1996: Kohtaro Fujihashi; S Kawabata; T Hiroi; Masato Yamamoto; Jerry R McGhee; S Nishikawa; Hiroshi Kiyono
Interleukin 2 (IL-2) and interleukin 7 (IL-7) reciprocally induce IL-7 and IL-2 receptors on gamma delta T-cell receptor-positive intraepithelial lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(8):3613-8.
1996: John L VanCott; T Kobayashi; Masato Yamamoto; S Pillai; Jerry R McGhee; Hiroshi Kiyono
Induction of pneumococcal polysaccharide-specific mucosal immune responses by oral immunization.
Vaccine 1996;14(5):392-8.
1996: Kohtaro Fujihashi; Jerry R McGhee; Mi-Na Kweon; Max D Cooper; Susumu Tonegawa; I Takahashi; T Hiroi; J Mestecky; Hiroshi Kiyono
gamma/delta T cell-deficient mice have impaired mucosal immunoglobulin A responses.
The Journal of experimental medicine 1996;183(4):1929-35.
1996: I Takahashi; Hiroshi Kiyono; Raymond J Jackson; Kohtaro Fujihashi; H F Staats; S Hamada; John Clements; Kenneth L Bost; Jerry R McGhee
Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine.
Infection and immunity 1996;64(4):1290-8.
1996: I Takahashi; M Marinaro; Hiroshi Kiyono; Raymond J Jackson; I Nakagawa; Kohtaro Fujihashi; S Hamada; John Clements; Kenneth L Bost; Jerry R McGhee
Mechanisms for mucosal immunogenicity and adjuvancy of Escherichia coli labile enterotoxin.
The Journal of infectious diseases 1996;173(3):627-35.
1996: Kohtaro Fujihashi; Masato Yamamoto; T Hiroi; T V Bamberg; Jerry R McGhee; Hiroshi Kiyono
Selected Th1 and Th2 cytokine mRNA expression by CD4(+) T cells isolated from inflamed human gingival tissues.
Clinical and experimental immunology 1996;103(3):422-8.
1996: John L VanCott; H F Staats; David W Pascual; M Roberts; Steven N Chatfield; Masato Yamamoto; M Coste; P B Carter; Hiroshi Kiyono; Jerry R McGhee
Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(4):1504-14.
1996: Masato Yamamoto; John L VanCott; N Okahashi; M Marinaro; Hiroshi Kiyono; Kohtaro Fujihashi; Raymond J Jackson; Steven N Chatfield; H Bluethmann; Jerry R McGhee
The role of Th1 and Th2 cells for mucosal IgA responses.
Annals of the New York Academy of Sciences 1996;778():64-71.
1996: Kohtaro Fujihashi; Jerry R McGhee; Masato Yamamoto; T Hiroi; Hiroshi Kiyono
Role of gamma delta T cells in the regulation of mucosal IgA response and oral tolerance.
Annals of the New York Academy of Sciences 1996;778():55-63.
1996: M Shimaoka; Takachika Hiroi; Hiroshi Kiyono
[The IgA immune system for mucosal vaccine: role of levels one and two Th2 cytokine producing T cells].
Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology 1996;19(1):114-8.
1996: Raymond J Jackson; M Marinaro; John L VanCott; Masato Yamamoto; N Okahashi; Kohtaro Fujihashi; Hiroshi Kiyono; Steven N Chatfield; Jerry R McGhee
Mucosal immunity: regulation by helper T cells and a novel method for detection.
Journal of biotechnology 1996;44(1-3):209-16.
1996: Masato Yamamoto; K Kawabata; Kohtaro Fujihashi; Jerry R McGhee; T E Van Dyke; T V Bamberg; T Hiroi; Hiroshi Kiyono
Absence of exogenous interleukin-4-induced apoptosis of gingival macrophages may contribute to chronic inflammation in periodontal diseases.
The American journal of pathology 1996;148(1):331-9.
1995: M Marinaro; H F Staats; T Hiroi; Raymond J Jackson; M Coste; Prosper N Boyaka; N Okahashi; Masato Yamamoto; Hiroshi Kiyono; H Bluethmann; Kohtaro Fujihashi; Jerry R McGhee
Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4621-9.
1995: T Hiroi; Kohtaro Fujihashi; Jerry R McGhee; Hiroshi Kiyono
Polarized Th2 cytokine expression by both mucosal gamma delta and alpha beta T cells.
European journal of immunology 1995;25(10):2743-51.
1995: Frederik W van Ginkel; C Liu; Jerry Simecka; Jian-Yun Dong; TE Greenway; R A Frizzell; Hiroshi Kiyono; Jerry R McGhee; David W Pascual
Intratracheal gene delivery with adenoviral vector induces elevated systemic IgG and mucosal IgA antibodies to adenovirus and beta-galactosidase.
Human gene therapy 1995;6(7):895-903.
1995: David W Pascual; Ken Beagley; Hiroshi Kiyono; Jerry R McGhee
Substance P promotes Peyer's patch and splenic B cell differentiation.
Advances in experimental medicine and biology 1995;371A():55-9.
1995: Wilhelm K Aicher; Hermann Eibel; Kohtaro Fujihashi; T Boehm; Ken Beagley; Jerry R McGhee; Hiroshi Kiyono
Analysis of intestinal intraepithelial lymphocyte (IEL) T cells in mice expressing anti-CD8 immunoglobulin transgenes.
Advances in experimental medicine and biology 1995;371A():125-8.
1995: J Mega; Jerry R McGhee; Hiroshi Kiyono
Characterization of cytokine producing T cells, TCR expression, and IgA plasma cells in salivary gland-associated tissues.
Advances in experimental medicine and biology 1995;371B():1103-8.
1994: T Hiroi; Kohtaro Fujihashi; Jerry R McGhee; Hiroshi Kiyono
Characterization of cytokine-producing cells in mucosal effector sites: CD3+ T cells of Th1 and Th2 type in salivary gland-associated tissues.
European journal of immunology 1994;24(11):2653-8.
1994: Raymond J Jackson; H F Staats; J Xu-Amano; I Takahashi; Hiroshi Kiyono; M E Hudson; R M Gilley; Steven N Chatfield; Jerry R McGhee
Oral vaccine models: multiple delivery systems employing tetanus toxoid.
Annals of the New York Academy of Sciences 1994;730():217-34.
1994: J Xu-Amano; Raymond J Jackson; Kohtaro Fujihashi; Hiroshi Kiyono; H F Staats; Jerry R McGhee
Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxin.
Vaccine 1994;12(10):903-11.
1994: H F Staats; Raymond J Jackson; M Marinaro; I Takahashi; Hiroshi Kiyono; Jerry R McGhee
Mucosal immunity to infection with implications for vaccine development.
Current opinion in immunology 1994;6(4):572-83.
1994: David W Pascual; Hiroshi Kiyono; Jerry R McGhee
The enteric nervous and immune systems: interactions for mucosal immunity and inflammation.
ImmunoMethods 1994;5(1):56-72.
1994: Masato Yamamoto; Kohtaro Fujihashi; M Amano; Jerry R McGhee; Ken Beagley; Hiroshi Kiyono
Cytokine synthesis and apoptosis by intestinal intraepithelial lymphocytes: signaling of high density alpha beta T cell receptor+ and gamma delta T cell receptor+ T cells via T cell receptor-CD3 complex results in interferon-gamma and interleukin-5 production, while low density T cells undergo DNA fragmentation.
European journal of immunology 1994;24(6):1301-6.
1994: Jerry R McGhee; Hiroshi Kiyono
Effective mucosal immunity. Current concepts for vaccine delivery and immune response analysis.
International journal of technology assessment in health care 1994;10(1):93-106.
1994: S Di Fabio; Innocent N Mbawuike; Hiroshi Kiyono; Kohtaro Fujihashi; Robert B Couch; Jerry R McGhee
Quantitation of human influenza virus-specific cytotoxic T lymphocytes: correlation of cytotoxicity and increased numbers of IFN-gamma producing CD8+ T cells.
International immunology 1994;6(1):11-9.
1994: Kohtaro Fujihashi; Masato Yamamoto; Jerry R McGhee; Hiroshi Kiyono
Function of alpha beta TCR+ and gamma delta TCR+ IELs for the gastrointestinal immune response.
International reviews of immunology 1994;11(1):1-14.
1994: Jerry R McGhee; J Xu-Amano; Christopher J Miller; Raymond J Jackson; Kohtaro Fujihashi; H F Staats; Hiroshi Kiyono
The common mucosal immune system: from basic principles to enteric vaccines with relevance for the female reproductive tract.
Reproduction, fertility, and development 1994;6(3):369-79.
1993: Kohtaro Fujihashi; Masato Yamamoto; Jerry R McGhee; Hiroshi Kiyono
alpha beta T cell receptor-positive intraepithelial lymphocytes with CD4+, CD8- and CD4+, CD8+ phenotypes from orally immunized mice provide Th2-like function for B cell responses.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(12):6681-91.
1993: Kohtaro Fujihashi; Masato Yamamoto; Jerry R McGhee; Ken Beagley; Hiroshi Kiyono
Function of alpha beta TCR+ intestinal intraepithelial lymphocytes: Th1- and Th2-type cytokine production by CD4+CD8- and CD4+CD8+ T cells for helper activity.
International immunology 1993;5(11):1473-81.
1993: Raymond J Jackson; Kohtaro Fujihashi; J Xu-Amano; Hiroshi Kiyono; Charles O Elson; Jerry R McGhee
Optimizing oral vaccines: induction of systemic and mucosal B-cell and antibody responses to tetanus toxoid by use of cholera toxin as an adjuvant.
Infection and immunity 1993;61(10):4272-9.
1993: J Xu-Amano; Hiroshi Kiyono; Raymond J Jackson; H F Staats; Kohtaro Fujihashi; Peter D Burrows; Charles O Elson; S Pillai; Jerry R McGhee
Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues.
The Journal of experimental medicine 1993;178(4):1309-20.
1993: Jerry R McGhee; Kohtaro Fujihashi; J Xu-Amano; Raymond J Jackson; Charles O Elson; Ken Beagley; Hiroshi Kiyono
New perspectives in mucosal immunity with emphasis on vaccine development.
Seminars in hematology 1993;30(4 Suppl 4):3-12; discussion 13-5.
1993: Ken Beagley; Kohtaro Fujihashi; CA Black; A S Lagoo; M Yamamoto; Jerry R McGhee; Hiroshi Kiyono
The Mycobacterium tuberculosis 71-kDa heat-shock protein induces proliferation and cytokine secretion by murine gut intraepithelial lymphocytes.
European journal of immunology 1993;23(8):2049-52.
1993: Kohtaro Fujihashi; Y Kono; Ken Beagley; Masato Yamamoto; Jerry R McGhee; Jiri Mestecky; Hiroshi Kiyono
Cytokines and periodontal disease: immunopathological role of interleukins for B cell responses in chronic inflamed gingival tissues.
Journal of periodontology 1993;64(5 Suppl):400-6.
1993: Kohtaro Fujihashi; Jerry R McGhee; Ken Beagley; David T McPherson; S A McPherson; C M Huang; Hiroshi Kiyono
Cytokine-specific ELISPOT assay. Single cell analysis of IL-2, IL-4 and IL-6 producing cells.
Journal of immunological methods 1993;160(2):181-9.
1993: Kohtaro Fujihashi; Ken Beagley; Y Kono; Wilhelm K Aicher; Masato Yamamoto; S DiFabio; J Xu-Amano; Jerry R McGhee; Hiroshi Kiyono
Gingival mononuclear cells from chronic inflammatory periodontal tissues produce interleukin (IL)-5 and IL-6 but not IL-2 and IL-4.
The American journal of pathology 1993;142(4):1239-50.
1993: Jerry R McGhee; Hiroshi Kiyono
New perspectives in vaccine development: mucosal immunity to infections.
Infectious agents and disease 1993;2(2):55-73.
1993: Masato Yamamoto; Kohtaro Fujihashi; Ken Beagley; Jerry R McGhee; Hiroshi Kiyono
Cytokine synthesis by intestinal intraepithelial lymphocytes. Both gamma/delta T cell receptor-positive and alpha/beta T cell receptor-positive T cells in the G1 phase of cell cycle produce IFN-gamma and IL-5.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(1):106-14.
1992: Kohtaro Fujihashi; Y Kono; Hiroshi Kiyono
Effects of IL6 on B cells in mucosal immune response and inflammation.
Research in immunology 1992;143(7):744-9.
1992: Wilhelm K Aicher; Kohtaro Fujihashi; Masato Yamamoto; Hiroshi Kiyono; A M Pitts; Jerry R McGhee
Effects of the lpr/lpr mutation on T and B cell populations in the lamina propria of the small intestine, a mucosal effector site.
International immunology 1992;4(9):959-68.
1992: Tomohiko Ogawa; Yutaka Kusumoto; Hiroshi Kiyono; J R McGhee; Shigeyuki Hamada
Occurrence of antigen-specific B cells following oral or parenteral immunization with Porphyromonas gingivalis fimbriae.
International immunology 1992;4(9):1003-10.
1992: Jerry R McGhee; Masato Yamamoto; D W Kang; John H Eldridge; J Mestecky; Z Moldoveanu; Richard W Compans; Hiroshi Kiyono; Christopher J Miller; Marta L Marthas
Isotype of anti-SIV responses in infected rhesus macaques and in animals immunized by mucosal routes.
AIDS research and human retroviruses 1992;8(8):1389.
1992: Christopher J Miller; D W Kang; Marta L Marthas; Z Moldoveanu; Hiroshi Kiyono; Preston Marx; John H Eldridge; J Mestecky; Jerry R McGhee
Genital secretory immune response to chronic simian immunodeficiency virus (SIV) infection: a comparison between intravenously and genitally inoculated rhesus macaques.
Clinical and experimental immunology 1992;88(3):520-6.
1992: Wilhelm K Aicher; M L McGhee; Jerry R McGhee; Zina Moldoveanu; Vincent J Kidd; Milan Tomana; Jiri Mestecky; John H Eldridge; T F Meyer; Hiroshi Kiyono
Properties of IgA-binding receptors on murine T cells: relative importance of Fc alpha R, beta-galactosyltransferase and anti-secretory component reactive proteins (ASCP).
Scandinavian journal of immunology 1992;35(4):469-86.
1992: J Mega; Jerry R McGhee; Hiroshi Kiyono
Cytokine- and Ig-producing T cells in mucosal effector tissues: analysis of IL-5- and IFN-gamma-producing T cells, T cell receptor expression, and IgA plasma cells from mouse salivary gland-associated tissues.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(7):2030-9.
1992: J Xu-Amano; Wilhelm K Aicher; T Taguchi; Hiroshi Kiyono; Jerry R McGhee
Selective induction of Th2 cells in murine Peyer's patches by oral immunization.
International immunology 1992;4(4):433-45.
1992: Kohtaro Fujihashi; T Taguchi; Wilhelm K Aicher; Jerry R McGhee; J A Bluestone; John H Eldridge; Hiroshi Kiyono
Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help.
The Journal of experimental medicine 1992;175(3):695-707.
1992: C Lue; Hiroshi Kiyono; Kohtaro Fujihashi; Jerry R McGhee; Jiri Mestecky
The use of the hu-PBL-SCID mouse model to study lymphocyte homing and responsiveness to recall antigens.
Regional immunology 1992;4(2):86-90.
1992: Hiroshi Kiyono; john bienenstock; Jerry R McGhee; Peter B Ernst
The mucosal immune system: features of inductive and effector sites to consider in mucosal immunization and vaccine development.
Regional immunology 1992;4(2):54-62.
1992: David W Pascual; Kenneth L Bost; J Xu-Amano; Hiroshi Kiyono; Jerry R McGhee
The cytokine-like action of substance P upon B cell differentiation.
Regional immunology 1992;4(2):100-4.
1992: J Mega; Kohtaro Fujihashi; Hiroshi Kiyono
Regulation of mucosal immune responses by T lymphocytes: the effect of chronic CD4+ T cell deficiency on IgA synthesis.
Regional immunology 1992;4(2):70-8.
1992: Marta L Marthas; Christopher J Miller; S Sutjipto; Joanne Higgins; J Torten; B L Lohman; R E Unger; R A Ramos; Hiroshi Kiyono; Jerry R McGhee
Efficacy of live-attenuated and whole-inactivated simian immunodeficiency virus vaccines against vaginal challenge with virulent SIV.
Journal of medical primatology 1992;21(2-3):99-107.
1992: Jerry R McGhee; Jiri Mestecky; M T Dertzbaugh; John H Eldridge; M Hirasawa; Hiroshi Kiyono
The mucosal immune system: from fundamental concepts to vaccine development.
Vaccine 1992;10(2):75-88.
1992: Wilhelm K Aicher; Kohtaro Fujihashi; T Taguchi; Jerry R McGhee; Masato Yamamoto; John H Eldridge; S Gay; Hiroshi Kiyono
Intestinal intraepithelial lymphocyte T cells are resistant to lpr gene-induced T cell abnormalities.
European journal of immunology 1992;22(1):137-45.
1992: Jerry R McGhee; Hiroshi Kiyono
Mucosal immunity to vaccines: current concepts for vaccine development and immune response analysis.
Advances in experimental medicine and biology 1992;327():3-12.
1992: J Mega; Kohtaro Fujihashi; Masato Yamamoto; Jerry R McGhee; M Hirasawa; Hiroshi Kiyono
Cytokine production and T cell receptor expression by salivary gland T cells and intraepithelial T lymphocytes for the regulation of the IgA response.
Advances in experimental medicine and biology 1992;327():119-31.
1992: J Xu-Amano; Ken Beagley; J Mega; Kohtaro Fujihashi; Hiroshi Kiyono; Jerry R McGhee
Induction of T helper cells and cytokines for mucosal IgA responses.
Advances in experimental medicine and biology 1992;327():107-17.
1991: D W Pascual; Jerry R McGhee; Hiroshi Kiyono; Kenneth L Bost
Neuroimmune modulation of lymphocyte function--I. Substance P enhances immunoglobulin synthesis in lipopolysaccharide activated murine splenic B cell cultures.
International immunology 1991;3(12):1223-9.
1991: T Taguchi; Wilhelm K Aicher; Kohtaro Fujihashi; Masato Yamamoto; Jerry R McGhee; J A Bluestone; Hiroshi Kiyono
Novel function for intestinal intraepithelial lymphocytes. Murine CD3+, gamma/delta TCR+ T cells produce IFN-gamma and IL-5.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(11):3736-44.
1991: David W Pascual; Kenneth L Bost; J Xu-Amano; Hiroshi Kiyono; Jerry R McGhee
The regulation of antibody responses by mini-cytokines.
Acta neurologica 1991;13(4):343-9.
1991: Kohtaro Fujihashi; Jerry R McGhee; C Lue; Ken Beagley; T Taga; T Hirano; T Kishimoto; Jiri Mestecky; Hiroshi Kiyono
Human appendix B cells naturally express receptors for and respond to interleukin 6 with selective IgA1 and IgA2 synthesis.
The Journal of clinical investigation 1991;88(1):248-52.
1991: David W Pascual; J C Xu-Amano; Hiroshi Kiyono; Jerry R McGhee; Kenneth L Bost
Substance P acts directly upon cloned B lymphoma cells to enhance IgA and IgM production.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(7):2130-6.
1991: Y Kono; Ken Beagley; Kohtaro Fujihashi; Jerry R McGhee; T Taga; T Hirano; T Kishimoto; Hiroshi Kiyono
Cytokine regulation of localized inflammation. Induction of activated B cells and IL-6-mediated polyclonal IgG and IgA synthesis in inflamed human gingiva.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(6):1812-21.
1991: C Lue; Hiroshi Kiyono; Jerry R McGhee; Kohtaro Fujihashi; T Kishimoto; T Hirano; Jiri Mestecky
Recombinant human interleukin 6 (rhIL-6) promotes the terminal differentiation of in vivo-activated human B cells into antibody-secreting cells.
Cellular immunology 1991;132(2):423-32.
1991: T Ogawa; Y Kono; M L McGhee; Jerry R McGhee; J E Roberts; S Hamada; Hiroshi Kiyono
Porphyromonas gingivalis-specific serum IgG and IgA antibodies originate from immunoglobulin-secreting cells in inflamed gingiva.
Clinical and experimental immunology 1991;83(2):237-44.
1991: Jerry R McGhee; Kohtaro Fujihashi; Ken Beagley; Hiroshi Kiyono
Role of interleukin-6 in human and mouse mucosal IgA plasma cell responses.
Immunologic research 1991;10(3-4):418-22.
1991: Hiroshi Kiyono; Kohtaro Fujihashi; T Taguchi; Wilhelm K Aicher; Jerry R McGhee
Regulatory functions for murine intraepithelial lymphocytes in mucosal responses.
Immunologic research 1991;10(3-4):324-30.
1991: Jerry R McGhee; Kohtaro Fujihashi; C Lue; Ken Beagley; Jiri Mestecky; Hiroshi Kiyono
Role of IL-6 in human antigen-specific and polyclonal IgA responses.
Advances in experimental medicine and biology 1991;310():113-21.
1990: T Ogawa; Y Kusumoto; S Hamada; Jerry R McGhee; Hiroshi Kiyono
Bacteroides gingivalis-specific serum IgG and IgA subclass antibodies in periodontal diseases.
Clinical and experimental immunology 1990;82(2):318-25.
1990: Kohtaro Fujihashi; T Taguchi; Jerry R McGhee; John H Eldridge; M G Bruce; D R Green; Bhagirath Singh; Hiroshi Kiyono
Regulatory function for murine intraepithelial lymphocytes. Two subsets of CD3+, T cell receptor-1+ intraepithelial lymphocyte T cells abrogate oral tolerance.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(7):2010-9.
1990: Wilhelm K Aicher; M L McGhee; Jerry R McGhee; John H Eldridge; Ken Beagley; T F Meyer; Hiroshi Kiyono
Mouse IgA Fc receptor on CD3+ T cells. Molecular forms of IgA that bind to a 38-kDa Fc alpha R protein and development of an anti-Fc alpha R antisera.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(6):1745-53.
1990: T Taguchi; Jerry R McGhee; R L Coffman; Ken Beagley; John H Eldridge; K Takatsu; Hiroshi Kiyono
Analysis of Th1 and Th2 cells in murine gut-associated tissues. Frequencies of CD4+ and CD8+ T cells that secrete IFN-gamma and IL-5.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(1):68-77.
1990: A Tarkowski; C Lue; Zina Moldoveanu; Hiroshi Kiyono; Jerry R McGhee; Jiri Mestecky
Immunization of humans with polysaccharide vaccines induces systemic, predominantly polymeric IgA2-subclass antibody responses.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(10):3770-8.
1990: T Taguchi; Jerry R McGhee; R L Coffman; Ken Beagley; John H Eldridge; K Takatsu; Hiroshi Kiyono
Detection of individual mouse splenic T cells producing IFN-gamma and IL-5 using the enzyme-linked immunospot (ELISPOT) assay.
Journal of immunological methods 1990;128(1):65-73.
1990: D Char; Wilhelm K Aicher; Jerry R McGhee; John H Eldridge; Ken Beagley; Hiroshi Kiyono
Induction of Fc alpha receptor expression on T cells from murine Peyer's patch, spleen and thymus.
Regional immunology 1990;3(5):228-35.
1990: Wilhelm K Aicher; Jerry R McGhee; Hiroshi Kiyono
Candidates for the mouse Fc alpha R: beta-galactosyl transferase, secretory component and a 38-kDa protein.
Research in immunology 1990;141(1):90-4; discussion 105-8.
1989: Kohtaro Fujihashi; Hiroshi Kiyono; Wilhelm K Aicher; D R Green; Bhagirath Singh; John H Eldridge; Jerry R McGhee
Immunoregulatory function of CD3+, CD4-, and CD8- T cells. Gamma delta T cell receptor-positive T cells from nude mice abrogate oral tolerance.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(11):3415-22.
1989: Ken Beagley; John H Eldridge; F Lee; Hiroshi Kiyono; MP Everson; William J Koopman; T Hirano; T Kishimoto; Jerry R McGhee
Interleukins and IgA synthesis. Human and murine interleukin 6 induce high rate IgA secretion in IgA-committed B cells.
The Journal of experimental medicine 1989;169(6):2133-48.
1989: Jerry R McGhee; Jiri Mestecky; Charles O Elson; Hiroshi Kiyono
Regulation of IgA synthesis and immune response by T cells and interleukins.
Journal of clinical immunology 1989;9(3):175-99.
1989: T Ogawa; M L McGhee; Zina Moldoveanu; S Hamada; Jiri Mestecky; Jerry R McGhee; Hiroshi Kiyono
Bacteroides-specific IgG and IgA subclass antibody-secreting cells isolated from chronically inflamed gingival tissues.
Clinical and experimental immunology 1989;76(1):103-10.
1989: M L McGhee; T Ogawa; A M Pitts; Zina Moldoveanu; Jiri Mestecky; Jerry R McGhee; Hiroshi Kiyono
Cellular analysis of functional mononuclear cells from chronically inflamed gingival tissue.
Regional immunology 1989;2(2):103-10.
1989: T Ogawa; A Tarkowski; M L McGhee; Zina Moldoveanu; Jiri Mestecky; H Z Hirsch; W J Koopman; S Hamada; Jerry R McGhee; Hiroshi Kiyono
Analysis of human IgG and IgA subclass antibody-secreting cells from localized chronic inflammatory tissue.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(4):1150-8.
1989: A Tarkowski; C Lue; Zina Moldoveanu; Hiroshi Kiyono; J R McGhee; Josef T Prchal; N B Halpern; Jiri Mestecky
Systemic immunization for the induction of IgA responses.
Current topics in microbiology and immunology 1989;146():161-8.
1989: Ken Beagley; Kohtaro Fujihashi; Wilhelm K Aicher; J Xu; Hiroshi Kiyono; John H Eldridge; M G Bruce; T Taguchi; D R Green; B Singh
Mucosal homeostasis: role of interleukins, isotype-specific factors and contrasuppression in the IgA response.
Immunological investigations 1989;18(1-4):77-89.
1988: Ken Beagley; John H Eldridge; Hiroshi Kiyono; MP Everson; William J Koopman; T Honjo; Jerry R McGhee
Recombinant murine IL-5 induces high rate IgA synthesis in cycling IgA-positive Peyer's patch B cells.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(6):2035-42.
1988: Jerry R McGhee; John H Eldridge; Ken Beagley; Hiroshi Kiyono
The possible involvement of CD3+, CD4- and CD8- T cells in immune responses.
Annales de l'Institut Pasteur. Immunology 1988;139(2):193-9.
1988: K Kitamura; Hiroshi Kiyono; Kohtaro Fujihashi; J H Eldrige; Ken Beagley; Jerry R McGhee
Isotype-specific immunoregulation. Systemic antigen induces splenic T contrasuppressor cells which support IgM and IgG subclass but not IgA responses.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(5):1385-92.
1988: Kohtaro Fujihashi; Hiroshi Kiyono; Ken Beagley; John H Eldridge; Jerry R McGhee
Role of the galt contrasuppressor T cell circuit in isotype-specific immunoregulation.
Advances in experimental medicine and biology 1988;237():649-53.
1988: Hiroshi Kiyono; D R Green; Jerry R McGhee
Contrasuppression in the mucosal immune system.
Immunologic research 1988;7(1):67-81.
1987: K Kitamura; Hiroshi Kiyono; Kohtaro Fujihashi; John H Eldridge; D R Green; Jerry R McGhee
Contrasuppressor cells that break oral tolerance are antigen-specific T cells distinct from T helper (L3T4+), T suppressor (Lyt-2+), and B cells.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(10):3251-9.
1987: T Kurita; Hiroshi Kiyono; M L McGhee; Jerry R McGhee
Isotype specific immunoregulation: role of Fc alpha R+ T cells and IBF alpha in IgA responses.
Advances in experimental medicine and biology 1987;216A():81-7.
1987: John H Eldridge; Hiroshi Kiyono; I Suzuki; K Kitamura; T Kurita; Ken Beagley; M L McGhee; Suzanne M Michalek; D R Green; Jerry R McGhee
Regulatory T cell networks in the secretory immune system.
Advances in experimental medicine and biology 1987;216A():45-55.
1987: K Kitamura; I Suzuki; Hiroshi Kiyono; T Kurita; A K Berry; D R Green; Jerry R McGhee
Isotype-specific immunoregulation: T contrasuppressor cells protect IgA responses in oral tolerance.
Advances in experimental medicine and biology 1987;216A():143-8.
1987: Hiroshi Kiyono; Jerry R McGhee
Mucosal T cell networks: role of Fc alpha R+ T cells and Ig BF alpha in the regulation of the IgA response.
International reviews of immunology 1987;2(2):157-82.
1987: Ken Beagley; Hiroshi Kiyono; C D Alley; John H Eldridge; Jerry R McGhee
Isolation of Peyer's patch T cell subsets involved in isotype specific immunoregulation.
Advances in experimental medicine and biology 1987;216A():177-83.