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Edward Baker
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59
Baker, Heather
34
Anderson, Bryan
27
Smith, Clyde
17
Arcus, Vickery
17
Lott, Shaun
12
Jameson, Geoffrey
11
Squire, Christopher
11
Tweedie, John
9
Proft, Thomas
8
Shewry, Steven
8
Mason, Anne
7
MacGillivray, Ross
7
Metcalf, Peter
7
Fraser, John
6
Kidd, Richard
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All Publications
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2009: Kang Hae Joo; Middleditch Martin; Proft Thomas; Baker Edward N
Isopeptide bonds in bacterial pili and their characterization by X-ray crystallography and mass spectrometry.
Biopolymers 2009;91(12):1126-34.
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2009: Kang Hae Joo; Paterson Neil G; Gaspar Andrew H; Ton-That Hung; Baker Edward N
The Corynebacterium diphtheriae shaft pilin SpaA is built of tandem Ig-like modules with stabilizing isopeptide and disulfide bonds.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(40):16967-71.
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2009: Linke Christian; Caradoc-Davies Tom T; Young Paul G; Proft Thomas; Baker Edward N
The laminin-binding protein Lbp from Streptococcus pyogenes is a zinc receptor.
Journal of bacteriology 2009;191(18):5814-23.
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2009: Kang Hae Joo; Paterson Neil G; Baker Edward N
Expression, purification, crystallization and preliminary crystallographic analysis of SpaA, a major pilin from Corynebacterium diphtheriae.
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 8):802-4.
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2009: Young Paul G; Walanj Rupa; Lakshmi Vendula; Byrnes Laura J; Metcalf Peter; Baker Edward N; Vakulenko Sergei B; Smith Clyde A
The crystal structures of substrate and nucleotide complexes of Enterococcus faecium aminoglycoside-2''-phosphotransferase-IIa [APH(2'')-IIa] provide insights into substrate selectivity in the APH(2'') subfamily.
Journal of bacteriology 2009;191(13):4133-43.
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2009: Zhang Zhening; Caradoc-Davies Tom T; Dickson James M; Baker Edward N; Squire Christopher J
Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery.
Journal of molecular biology 2009;389(4):722-33.
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2009: Zhang Zhening; Bulloch Esther M M; Bunker Richard D; Baker Edward N; Squire Christopher J
Structure and function of GlmU from Mycobacterium tuberculosis.
Acta crystallographica. Section D, Biological crystallography 2009;65(Pt 3):275-83.
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2009: Moreland Nicole J; Charlier Caroline; Dingley Andrew J; Baker Edward N; Lott J Shaun
Making sense of a missense mutation: characterization of MutT2, a Nudix hydrolase from Mycobacterium tuberculosis, and the G58R mutant encoded in W-Beijing strains of M. tuberculosis.
Biochemistry 2009;48(4):699-708.
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2009: Proft T; Baker E N
Pili in Gram-negative and Gram-positive bacteria - structure, assembly and their role in disease.
Cellular and molecular life sciences : CMLS 2009;66(4):613-35.
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2009: Baker Edward N; Baker Heather M
A structural framework for understanding the multifunctional character of lactoferrin.
Biochimie 2009;91(1):3-10.
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2008: Sharpe Miriam L; Gao Chen; Kendall Sharon L; Baker Edward N; Lott J Shaun
The structure and unusual protein chemistry of hypoxic response protein 1, a latency antigen and highly expressed member of the DosR regulon in Mycobacterium tuberculosis.
Journal of molecular biology 2008;383(4):822-36.
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2008: Watkins Harriet A; Baker Edward N
Cloning, expression, purification and preliminary crystallographic analysis of the RNase HI domain of the Mycobacterium tuberculosis protein Rv2228c as a maltose-binding protein fusion.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 8):746-9.
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2008: Young Paul G; Smith Clyde A; Metcalf Peter; Baker Edward N
Structures of Mycobacterium tuberculosis folylpolyglutamate synthase complexed with ADP and AMPPCP.
Acta crystallographica. Section D, Biological crystallography 2008;D64(Pt 7):745-53.
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2008: Bunker Richard D; McKenzie Joanna L; Baker Edward N; Arcus Vickery L
Crystal structure of PAE0151 from Pyrobaculum aerophilum, a PIN-domain (VapC) protein from a toxin-antitoxin operon.
Proteins 2008;72(1):510-8.
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2008: Bashiri Ghader; Squire Christopher J; Moreland Nicole J; Baker Edward N
Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding.
The Journal of biological chemistry 2008;283(25):17531-41.
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2008: Smaill Jeff B; Baker Edward N; Booth R John; Bridges Alexander J; Dickson James M; Dobrusin Ellen M; Ivanovic Ivan; Kraker Alan J; Lee Ho H; Lunney Elizabeth A; Ortwine Daniel F; Palmer Brian D; Quin John; Squire Christopher J; Thompson Andrew M; Denny William A
Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases.
European journal of medicinal chemistry 2008;43(6):1276-96.
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2008: Linke Christian; Caradoc-Davies Tom T; Proft Thomas; Baker Edward N
Purification, crystallization and preliminary crystallographic analysis of Streptococcus pyogenes laminin-binding protein Lbp.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 2):141-3.
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2008: Smaill Jeff B; Lee Ho H; Palmer Brian D; Thompson Andrew M; Squire Christopher J; Baker Edward N; Booth R John; Kraker Alan; Hook Ken; Denny William A
Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases.
Bioorganic & medicinal chemistry letters 2008;18(3):929-33.
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2008: Goldstone Rachael M; Moreland Nicole J; Bashiri Ghader; Baker Edward N; Shaun Lott J
A new Gateway vector and expression protocol for fast and efficient recombinant protein expression in Mycobacterium smegmatis.
Protein expression and purification 2008;57(1):81-7.
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2007: Kang Hae Joo; Coulibaly Fasséli; Clow Fiona; Proft Thomas; Baker Edward N
Stabilizing isopeptide bonds revealed in gram-positive bacterial pilus structure.
Science (New York, N.Y.) 2007;318(5856):1625-8.
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2007: Chung Matthew C; Wines Bruce D; Baker Heather; Langley Ries J; Baker Edward N; Fraser John D
The crystal structure of staphylococcal superantigen-like protein 11 in complex with sialyl Lewis X reveals the mechanism for cell binding and immune inhibition.
Molecular microbiology 2007;66(6):1342-55.
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2007: Baker Heather M; Basu Indira; Chung Matthew C; Caradoc-Davies Tom; Fraser John D; Baker Edward N
Crystal structures of the staphylococcal toxin SSL5 in complex with sialyl Lewis X reveal a conserved binding site that shares common features with viral and bacterial sialic acid binding proteins.
Journal of molecular biology 2007;374(5):1298-308.
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2007: Watson Randall P; Demmer Jerome; Baker Edward N; Arcus Vickery L
Three-dimensional structure and ligand binding properties of trichosurin, a metatherian lipocalin from the milk whey of the common brushtail possum Trichosurus vulpecula.
The Biochemical journal 2007;408(1):29-38.
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2007: Hyun Jae-Kyung; Coulibaly Fasséli; Turner Adrian P; Baker Edward N; Mercer Andrew A; Mitra Alok K
The structure of a putative scaffolding protein of immature poxvirus particles as determined by electron microscopy suggests similarity with capsid proteins of large icosahedral DNA viruses.
Journal of virology 2007;81(20):11075-83.
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2007: Baker Edward N
Structural genomics as an approach towards understanding the biology of tuberculosis.
Journal of structural and functional genomics 2007;8(2-3):57-65.
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2007: Bashiri Ghader; Squire Christopher J; Baker Edward N; Moreland Nicole J
Expression, purification and crystallization of native and selenomethionine labeled Mycobacterium tuberculosis FGD1 (Rv0407) using a Mycobacterium smegmatis expression system.
Protein expression and purification 2007;54(1):38-44.
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2007: Murillo A C; Li H Y; Alber T; Baker E N; Berger J M; Cherney L T; Cherney M M; Cho Yoon Song; Eisenberg D; Garen C R; Goulding C W; Hung L W; Ioerger T R; Jacobs W R; James M N G; Kim C; Krieger I; Lott J S; Sankaranarayanan R; Segelke B W; Terwilliger T C; Wang F; Wang S; Sacchettini J C
High throughput crystallography of TB drug targets.
Infectious disorders drug targets 2007;7(2):127-39.
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2007: Baker Heather M; Nurizzo Didier; Mason Anne B; Baker Edward N
Structures of two mutants that probe the role in iron release of the dilysine pair in the N-lobe of human transferrin.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 3):408-14.
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2007: Ileperuma Nadeesha R; Marshall Sean D G; Squire Christopher J; Baker Heather M; Oakeshott John G; Russell Robyn J; Plummer Kim M; Newcomb Richard D; Baker Edward N
High-resolution crystal structure of plant carboxylesterase AeCXE1, from Actinidia eriantha, and its complex with a high-affinity inhibitor paraoxon.
Biochemistry 2007;46(7):1851-9.
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2006: Deva Taru; Baker Edward N; Squire Christopher J; Smith Clyde A
Structure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC).
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 12):1466-74.
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2006: Brown Peter M; Caradoc-Davies Tom T; Dickson James M J; Cooper Garth J S; Loomes Kerry M; Baker Edward N
Crystal structure of a substrate complex of myo-inositol oxygenase, a di-iron oxygenase with a key role in inositol metabolism.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(41):15032-7.
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2006: Harrison Anthony J; Yu Minmin; Gårdenborg Therés; Middleditch Martin; Ramsay Rochelle J; Baker Edward N; Lott J Shaun
The structure of MbtI from Mycobacterium tuberculosis, the first enzyme in the biosynthesis of the siderophore mycobactin, reveals it to be a salicylate synthase.
Journal of bacteriology 2006;188(17):6081-91.
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2006: Brown Peter M; Caradoc-Davies Tom T; Dickson James M; Cooper Garth J S; Loomes Kerry M; Baker Edward N
Purification, crystallization and preliminary crystallographic analysis of mouse myo-inositol oxygenase.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 8):811-3.
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2006: Lott J Shaun; Paget Blake; Johnston Jodie M; Delbaere Louis T J; Sigrell-Simon Jill A; Banfield Mark J; Baker Edward N
The structure of an ancient conserved domain establishes a structural basis for stable histidine phosphorylation and identifies a new family of adenosine-specific kinases.
The Journal of biological chemistry 2006;281(31):22131-41.
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2006: Young P G; Smith C A; Sun X; Baker E N; Metcalf P
Purification, crystallization and preliminary X-ray analysis of Mycobacterium tuberculosisfolylpolyglutamate synthase (MtbFPGS).
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 6):579-82.
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2006: Watkins Harriet A; Baker Edward N
Structural and functional analysis of Rv3214 from Mycobacterium tuberculosis, a protein with conflicting functional annotations, leads to its characterization as a phosphatase.
Journal of bacteriology 2006;188(10):3589-99.
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2006: Arcus Vickery L; Lott J Shaun; Johnston Jodie M; Baker Edward N
The potential impact of structural genomics on tuberculosis drug discovery.
Drug discovery today 2006;11(1-2):28-34.
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2006: Lee Clare E; Goodfellow Catherine; Javid-Majd Farah; Baker Edward N; Shaun Lott J
The crystal structure of TrpD, a metabolic enzyme essential for lung colonization by Mycobacterium tuberculosis, in complex with its substrate phosphoribosylpyrophosphate.
Journal of molecular biology 2006;355(4):784-97.
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2005: Webby Celia J; Baker Heather M; Lott J Shaun; Baker Edward N; Parker Emily J
The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes.
Journal of molecular biology 2005;354(4):927-39.
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2005: Baker E N
Lactoferrin: a multi-tasking protein par excellence.
Cellular and molecular life sciences : CMLS 2005;62(22):2529-30.
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2005: Baker E N; Baker H M
Molecular structure, binding properties and dynamics of lactoferrin.
Cellular and molecular life sciences : CMLS 2005;62(22):2531-9.
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2005: Moreland Nicole; Ashton Rachael; Baker Heather M; Ivanovic Ivan; Patterson Sean; Arcus Vickery L; Baker Edward N; Lott J Shaun
A flexible and economical medium-throughput strategy for protein production and crystallization.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 10):1378-85.
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2005: Johnston Jodie M; Arcus Vickery L; Baker Edward N
Structure of naphthoate synthase (MenB) from Mycobacterium tuberculosis in both native and product-bound forms.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 9):1199-206.
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2005: Watkins Harriet A; Yu MinMin; Baker Edward N
Cloning, expression, purification and preliminary crystallographic data for Rv3214 (EntD), a predicted cofactor-dependent phosphoglycerate mutase from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 8):753-5.
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2005: Sharpe Miriam L; Baker Edward N; Lott J Shaun
Crystallization of a protein using dehydration without a precipitant.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 6):565-8.
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2005: Walanj Rupa; Young Paul; Baker Heather M; Baker Edward N; Metcalf Peter; Chow Joseph W; Lerner Stephen; Vakulenko Sergei; Smith Clyde A
Purification, crystallization and preliminary X-ray analysis of Enterococcus faecium aminoglycoside-2''-phosphotransferase-Ib [APH(2'')-Ib].
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 4):410-3.
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2005: Webby Celia J; Lott J Shaun; Baker Heather M; Baker Edward N; Parker Emily J
Crystallization and preliminary X-ray crystallographic analysis of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 4):403-6.
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2005: Squire Christopher J; Dickson James M; Ivanovic Ivan; Baker Edward N
Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation.
Structure (London, England : 1993) 2005;13(4):541-50.
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2005: Card Graeme L; Peterson Neil A; Smith Clyde A; Rupp Bernhard; Schick Brian M; Baker Edward N
The crystal structure of Rv1347c, a putative antibiotic resistance protein from Mycobacterium tuberculosis, reveals a GCN5-related fold and suggests an alternative function in siderophore biosynthesis.
The Journal of biological chemistry 2005;280(14):13978-86.
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2005: Li Simon; Peterson Neil A; Kim Min-Young; Kim Chang-Yub; Hung Li-Wei; Yu Minmin; Lekin Timothy; Segelke Brent W; Lott J Shaun; Baker Edward N
Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys peroxiredoxin.
Journal of molecular biology 2005;346(4):1035-46.
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2005: Goldstone David; Baker Edward N; Metcalf Peter
Crystallization and preliminary diffraction studies of the C-terminal domain of the DipZ homologue from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 2):243-5.
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2005: Harrison Anthony J; Ramsay Rochelle J; Baker Edward N; Lott J Shaun
Crystallization and preliminary X-ray crystallographic analysis of MbtI, a protein essential for siderophore biosynthesis in Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 1):121-3.
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2004: Baker Heather M; Proft Thomas; Webb Phillip D; Arcus Vickery L; Fraser John D; Baker Edward N
Crystallographic and mutational data show that the streptococcal pyrogenic exotoxin J can use a common binding surface for T-cell receptor binding and dimerization.
The Journal of biological chemistry 2004;279(37):38571-6.
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2004: Cornish Jillian; Callon Karen E; Naot Dorit; Palmano Kate P; Banovic Tatjana; Bava Usha; Watson Maureen; Lin Jian-Ming; Tong P C; Chen Qi; Chan Vincent A; Reid Helen E; Fazzalari Nick; Baker Heather M; Baker Edward N; Haggarty Neill W; Grey Andrew B; Reid Ian R
Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo.
Endocrinology 2004;145(9):4366-74.
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2004: Baker Heather M; Baker Edward N
Lactoferrin and iron: structural and dynamic aspects of binding and release.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2004;17(3):209-16.
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2004: Koon Nayden; Squire Christopher J; Baker Edward N
Crystallization and preliminary X-ray analysis of alpha-isopropylmalate synthase from Mycobacterium tuberculosis.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 6):1167-9.
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2004: Koon Nayden; Squire Christopher J; Baker Edward N
Crystal structure of LeuA from Mycobacterium tuberculosis, a key enzyme in leucine biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(22):8295-300.
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2004: Bäckbro Kristina; Roos Annette; Baker Edward N; Arcus Vickery L
Crystallization and preliminary X-ray analysis of a conserved hypothetical protein PAE2754 from Pyrobaculum aerophilum and of a double Leu-->Met mutant engineered for MAD phasing.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 4):733-5.
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2004: Arcus Vickery L; Bäckbro Kristina; Roos Annette; Daniel Emma L; Baker Edward N
Distant structural homology leads to the functional characterization of an archaeal PIN domain as an exonuclease.
The Journal of biological chemistry 2004;279(16):16471-8.
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2004: Lott J Shaun; Baker Edward N
Using structural genomics to understand Mycobacterium tuberculosis.
IUBMB life 2004;56(3):113-7.
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2004: McCarthy Andrew A; Peterson Neil A; Knijff Rainer; Baker Edward N
Crystal structure of MshB from Mycobacterium tuberculosis, a deacetylase involved in mycothiol biosynthesis.
Journal of molecular biology 2004;335(4):1131-41.
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2003: McCarthy Andrew A; Knijff Rainer; Peterson Neil A; Baker Edward N
Crystallization and preliminary X-ray analysis of N-acetyl-1-D-myo-inosityl-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 12):2316-8.
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2003: Lott J Shaun; Banfield Mark J; Sigrell Jill; Baker Edward N
Making the most of two crystals: structural analysis of a conserved hypothetical protein using native gel screening and SAD phasing.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 12):2242-6.
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2003: Deva Taru; Pryor KellyAnn D; Leiting Barbara; Baker Edward N; Smith Clyde A
Purification, crystallization and preliminary X-ray analysis of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC).
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 8):1510-3.
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2003: Johnston Jodie M; Arcus Vickery L; Morton Craig J; Parker Michael W; Baker Edward N
Crystal structure of a putative methyltransferase from Mycobacterium tuberculosis: misannotation of a genome clarified by protein structural analysis.
Journal of bacteriology 2003;185(14):4057-65.
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2003: Baker Heather M; He Qing-Yu; Briggs Sara K; Mason Anne B; Baker Edward N
Structural and functional consequences of binding site mutations in transferrin: crystal structures of the Asp63Glu and Arg124Ala mutants of the N-lobe of human transferrin.
Biochemistry 2003;42(23):7084-9.
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2003: Baker Heather M; Anderson Bryan F; Baker Edward N
Dealing with iron: common structural principles in proteins that transport iron and heme.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):3579-83.
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2003: Nurizzo Didier; Shewry Steven C; Perlin Michael H; Brown Scott A; Dholakia Jaydev N; Fuchs Roy L; Deva Taru; Baker Edward N; Smith Clyde A
The crystal structure of aminoglycoside-3'-phosphotransferase-IIa, an enzyme responsible for antibiotic resistance.
Journal of molecular biology 2003;327(2):491-506.
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2003: Hendrixson D R; Qiu J; Shewry S C; Fink D L; Petty S; Baker E N; Plaut A G; St Geme J W
Human milk lactoferrin is a serine protease that cleaves Haemophilus surface proteins at arginine-rich sites.
Molecular microbiology 2003;47(3):607-17.
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2003: Baker Edward N; Arcus Vickery L; Lott J Shaun
Protein structure prediction and analysis as a tool for functional genomics.
Applied bioinformatics 2003;2(3 Suppl):S3-10.
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2002: Peterson Neil A; Arcus Vickery L; Anderson Bryan F; Tweedie John W; Jameson Geoffrey B; Baker Edward N
"Dilysine trigger" in transferrins probed by mutagenesis of lactoferrin: crystal structures of the R210G, R210E, and R210L mutants of human lactoferrin.
Biochemistry 2002;41(48):14167-75.
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2002: Arcus Vickery L; Langley Ries; Proft Thomas; Fraser John D; Baker Edward N
The Three-dimensional structure of a superantigen-like protein, SET3, from a pathogenicity island of the Staphylococcus aureus genome.
The Journal of biological chemistry 2002;277(35):32274-81.
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2002: Smith Clyde A; Baker Edward N
Aminoglycoside antibiotic resistance by enzymatic deactivation.
Current drug targets. Infectious disorders 2002;2(2):143-60.
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2002: Goulding Celia W; Apostol Marcin; Anderson Daniel H; Gill Harindarpal S; Smith Clare V; Kuo Mack R; Yang Jin Kuk; Waldo Geoffrey S; Suh Se Won; Chauhan Radha; Kale Avinash; Bachhawat Nandita; Mande Shekhar C; Johnston Jodie M; Lott J Shaun; Baker Edward N; Arcus Vickery L; Leys David; McLean Kirsty J; Munro Andrew W; Berendzen Joel; Sharma Vivek; Park Min S; Eisenberg David; Sacchettini James; Alber Tom; Rupp Bernhard; Jacobs William; Terwilliger Thomas C
The TB structural genomics consortium: providing a structural foundation for drug discovery.
Current drug targets. Infectious disorders 2002;2(2):121-41.
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2002: Jameson Geoffrey B; Anderson Bryan F; Breyer Wendy A; Day Catherine L; Tweedie John W; Baker Edward N
Structure of a domain-opened mutant (R121D) of the human lactoferrin N-lobe refined from a merohedrally twinned crystal form.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 6 Pt 2):955-62.
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2002: Brittain Thomas; Kidd Richard D; Baker Edward N
Electron transfer between cytochrome b(5) and some oxidised haemoglobins: the role of ionic strength.
Journal of inorganic biochemistry 2002;88(3-4):328-34.
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2002: Kidd Richard D; Baker Edward N; Brittain Thomas
A modeling study of the interaction and electron transfer between cytochrome b5 and some oxidized haemoglobins.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2002;7(1-2):23-30.
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2002: Baker Edward N; Baker Heather M; Kidd Richard D
Lactoferrin and transferrin: functional variations on a common structural framework.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2002;80(1):27-34.
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2001: Kidd R D; Russell J E; Watmough N J; Baker E N; Brittain T
The role of beta chains in the control of the hemoglobin oxygen binding function: chimeric human/mouse proteins, structure, and function.
Biochemistry 2001;40(51):15669-75.
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2001: Nurizzo D; Halbig D; Sprenger G A; Baker E N
Crystal structures of the precursor form of glucose-fructose oxidoreductase from Zymomonas mobilis and its complexes with bound ligands.
Biochemistry 2001;40(46):13857-67.
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2001: Banfield M J; Lott J S; Arcus V L; McCarthy A A; Baker E N
Structure of HisF, a histidine biosynthetic protein from Pyrobaculum aerophilum.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 11):1518-25.
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2001: Baker H M; Mason A B; He Q Y; MacGillivray R T; Baker E N
Ligand variation in the transferrin family: the crystal structure of the H249Q mutant of the human transferrin N-lobe as a model for iron binding in insect transferrins.
Biochemistry 2001;40(39):11670-5.
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2001: Moore S A; Kingston R L; Loomes K M; Hernell O; Bläckberg L; Baker H M; Baker E N
The structure of truncated recombinant human bile salt-stimulated lipase reveals bile salt-independent conformational flexibility at the active-site loop and provides insights into heparin binding.
Journal of molecular biology 2001;312(3):511-23.
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2001: Haebel P W; Arcus V L; Baker E N; Metcalf P
LISA: an intranet-based flexible database for protein crystallography project management.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 9):1341-3.
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2001: Kidd R D; Baker H M; Mathews A J; Brittain T; Baker E N
Oligomerization and ligand binding in a homotetrameric hemoglobin: two high-resolution crystal structures of hemoglobin Bart's (gamma(4)), a marker for alpha-thalassemia.
Protein science : a publication of the Protein Society 2001;10(9):1739-49.
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2001: Sun X; Cross J A; Bognar A L; Baker E N; Smith C A
Folate-binding triggers the activation of folylpolyglutamate synthetase.
Journal of molecular biology 2001;310(5):1067-78.
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2001: McCarthy A A; Baker H M; Shewry S C; Patchett M L; Baker E N
Crystal structure of methylmalonyl-coenzyme A epimerase from P. shermanii: a novel enzymatic function on an ancient metal binding scaffold.
Structure (London, England : 1993) 2001;9(7):637-46.
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2001: Kidd R D; Mathews A; Baker H M; Brittain T; Baker E N
Subunit dissociation and reassociation leads to preferential crystallization of haemoglobin Bart's (gamma4) from solutions of human embryonic haemoglobin Portland (zeta2gamma2) at low pH.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 6):921-4.
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2001: Proft T; Arcus V L; Handley V; Baker E N; Fraser J D
Immunological and biochemical characterization of streptococcal pyrogenic exotoxins I and J (SPE-I and SPE-J) from Streptococcus pyogenes.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(11):6711-9.
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2001: McCarthy A A; Baker H M; Shewry S C; Kagawa T F; Saafi E; Patchett M L; Baker E N
Expression, crystallization and preliminary characterization of methylmalonyl coenzyme A epimerase from Propionibacterium shermanii.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 5):706-8.
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2001: Edwards R A; Whittaker M M; Whittaker J W; Baker E N; Jameson G B
Removing a hydrogen bond in the dimer interface of Escherichia coli manganese superoxide dismutase alters structure and reactivity.
Biochemistry 2001;40(15):4622-32.
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2001: Nurizzo D; Baker H M; He Q Y; MacGillivray R T; Mason A B; Woodworth R C; Baker E N
Crystal structures and iron release properties of mutants (K206A and K296A) that abolish the dilysine interaction in the N-lobe of human transferrin.
Biochemistry 2001;40(6):1616-23.
-
2001: Banfield M J; Salvucci M E; Baker E N; Smith C A
Crystal structure of the NADP(H)-dependent ketose reductase from Bemisia argentifolii at 2.3 A resolution.
Journal of molecular biology 2001;306(2):239-50.
-
2001: Edwards R A; Whittaker M M; Whittaker J W; Baker E N; Jameson G B
Outer sphere mutations perturb metal reactivity in manganese superoxide dismutase.
Biochemistry 2001;40(1):15-27.
-
2000: Baker H M; Baker C J; Smith C A; Baker E N
Metal substitution in transferrins: specific binding of cerium(IV) revealed by the crystal structure of cerium-substituted human lactoferrin.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2000;5(6):692-8.
-
2000: Lott J S; Halbig D; Baker H M; Hardman M J; Sprenger G A; Baker E N
Crystal structure of a truncated mutant of glucose-fructose oxidoreductase shows that an N-terminal arm controls tetramer formation.
Journal of molecular biology 2000;304(4):575-84.
-
2000: McCarthy A A; Morris D D; Bergquist P L; Baker E N
Structure of XynB, a highly thermostable beta-1,4-xylanase from Dictyoglomus thermophilum Rt46B.1, at 1.8 A resolution.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 11):1367-75.
-
2000: Sheng Y; Sun X; Shen Y; Bognar A L; Baker E N; Smith C A
Structural and functional similarities in the ADP-forming amide bond ligase superfamily: implications for a substrate-induced conformational change in folylpolyglutamate synthetase.
Journal of molecular biology 2000;302(2):427-40.
-
2000: Peterson N A; Anderson B F; Jameson G B; Tweedie J W; Baker E N
Crystal structure and iron-binding properties of the R210K mutant of the N-lobe of human lactoferrin: implications for iron release from transferrins.
Biochemistry 2000;39(22):6625-33.
-
2000: Arcus V L; Proft T; Sigrell J A; Baker H M; Fraser J D; Baker E N
Conservation and variation in superantigen structure and activity highlighted by the three-dimensional structures of two new superantigens from Streptococcus pyogenes.
Journal of molecular biology 2000;299(1):157-68.
-
2000: Kingston R L; Baker H M; Loomes K M; Bläckberg L; Hernell O; Baker E N
Crystallization and preliminary X-ray analysis of native and recombinant human bile-salt dependent lipase: strategies for improvement of diffraction quality.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 4):478-80.
-
2000: McCarthy A A; Haebel P W; Törrönen A; Rybin V; Baker E N; Metcalf P
Crystal structure of the protein disulfide bond isomerase, DsbC, from Escherichia coli.
Nature structural biology 2000;7(3):196-9.
-
2000: MacGillivray R T; Bewley M C; Smith C A; He Q Y; Mason A B; Woodworth R C; Baker E N
Mutation of the iron ligand His 249 to Glu in the N-lobe of human transferrin abolishes the dilysine "trigger" but does not significantly affect iron release.
Biochemistry 2000;39(6):1211-6.
-
2000: Kagawa T F; Cooney J C; Baker H M; McSweeney S; Liu M; Gubba S; Musser J M; Baker E N
Crystal structure of the zymogen form of the group A Streptococcus virulence factor SpeB: an integrin-binding cysteine protease.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2235-40.
-
1999: Smith C A; Toogood H S; Baker H M; Daniel R M; Baker E N
Calcium-mediated thermostability in the subtilisin superfamily: the crystal structure of Bacillus Ak.1 protease at 1.8 A resolution.
Journal of molecular biology 1999;294(4):1027-40.
-
1999: Paoli M; Anderson B F; Baker H M; Morgan W T; Smith A; Baker E N
Crystal structure of hemopexin reveals a novel high-affinity heme site formed between two beta-propeller domains.
Nature structural biology 1999;6(10):926-31.
-
1999: Bewley M C; Jeffrey P D; Patchett M L; Kanyo Z F; Baker E N
Crystal structures of Bacillus caldovelox arginase in complex with substrate and inhibitors reveal new insights into activation, inhibition and catalysis in the arginase superfamily.
Structure (London, England : 1993) 1999;7(4):435-48.
-
1999: Sun X L; Baker H M; Shewry S C; Jameson G B; Baker E N
Structure of recombinant human lactoferrin expressed in Aspergillus awamori.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 2):403-7.
-
1999: Bewley M C; Tam B M; Grewal J; He S; Shewry S; Murphy M E; Mason A B; Woodworth R C; Baker E N; MacGillivray R T
X-ray crystallography and mass spectroscopy reveal that the N-lobe of human transferrin expressed in Pichia pastoris is folded correctly but is glycosylated on serine-32.
Biochemistry 1999;38(8):2535-41.
-
1999: Qin B Y; Bewley M C; Creamer L K; Baker E N; Jameson G B
Functional implications of structural differences between variants A and B of bovine beta-lactoglobulin.
Protein science : a publication of the Protein Society 1999;8(1):75-83.
-
1999: Breyer W A; Kingston R L; Anderson B F; Baker E N
On the molecular-replacement problem in the presence of merohedral twinning: structure of the N-terminal half-molecule of human lactoferrin.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 1):129-38.
-
1999: Moore S A; Baker H M; Blythe T J; Kitson K E; Kitson T M; Baker E N
A structural explanation for the retinal specificity of class 1 ALDH enzymes.
Advances in experimental medicine and biology 1999;463():27-38.
-
1998: Moore S A; Baker H M; Blythe T J; Kitson K E; Kitson T M; Baker E N
Sheep liver cytosolic aldehyde dehydrogenase: the structure reveals the basis for the retinal specificity of class 1 aldehyde dehydrogenases.
Structure (London, England : 1993) 1998;6(12):1541-51.
-
1998: Jameson G B; Anderson B F; Norris G E; Thomas D H; Baker E N
Structure of human apolactoferrin at 2.0 A resolution. Refinement and analysis of ligand-induced conformational change.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 6 Pt 2):1319-35.
-
1998: Qin B Y; Creamer L K; Baker E N; Jameson G B
12-Bromododecanoic acid binds inside the calyx of bovine beta-lactoglobulin.
FEBS letters 1998;438(3):272-8.
-
1998: Qiu J; Hendrixson D R; Baker E N; Murphy T F; St Geme J W; Plaut A G
Human milk lactoferrin inactivates two putative colonization factors expressed by Haemophilus influenzae.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12641-6.
-
1998: Qin B Y; Bewley M C; Creamer L K; Baker H M; Baker E N; Jameson G B
Structural basis of the Tanford transition of bovine beta-lactoglobulin.
Biochemistry 1998;37(40):14014-23.
-
1998: Jeffrey P D; Bewley M C; MacGillivray R T; Mason A B; Woodworth R C; Baker E N
Ligand-induced conformational change in transferrins: crystal structure of the open form of the N-terminal half-molecule of human transferrin.
Biochemistry 1998;37(40):13978-86.
-
1998: Sutherland-Smith A J; Baker H M; Hofmann O M; Brittain T; Baker E N
Crystal structure of a human embryonic haemoglobin: the carbonmonoxy form of gower II (alpha2 epsilon2) haemoglobin at 2.9 A resolution.
Journal of molecular biology 1998;280(3):475-84.
-
1998: Sun X; Bognar A L; Baker E N; Smith C A
Structural homologies with ATP- and folate-binding enzymes in the crystal structure of folylpolyglutamate synthetase.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6647-52.
-
1998: MacGillivray R T; Moore S A; Chen J; Anderson B F; Baker H; Luo Y; Bewley M; Smith C A; Murphy M E; Wang Y; Mason A B; Woodworth R C; Brayer G D; Baker E N
Two high-resolution crystal structures of the recombinant N-lobe of human transferrin reveal a structural change implicated in iron release.
Biochemistry 1998;37(22):7919-28.
-
1998: Baker E N; Anderson B F; Baker H M; MacGillivray R T; Moore S A; Peterson N A; Shewry S C; Tweedie J W
Three-dimensional structure of lactoferrin. Implications for function, including comparisons with transferrin.
Advances in experimental medicine and biology 1998;443():1-14.
-
1997: Moore S A; Anderson B F; Groom C R; Haridas M; Baker E N
Three-dimensional structure of diferric bovine lactoferrin at 2.8 A resolution.
Journal of molecular biology 1997;274(2):222-36.
-
1997: Roussel A; Anderson B F; Baker H M; Fraser J D; Baker E N
Crystal structure of the streptococcal superantigen SPE-C: dimerization and zinc binding suggest a novel mode of interaction with MHC class II molecules.
Nature structural biology 1997;4(8):635-43.
-
1997: Nicholson H; Anderson B F; Bland T; Shewry S C; Tweedie J W; Baker E N
Mutagenesis of the histidine ligand in human lactoferrin: iron binding properties and crystal structure of the histidine-253-->methionine mutant.
Biochemistry 1997;36(2):341-6.
-
1996: Kingston R L; Scopes R K; Baker E N
The structure of glucose-fructose oxidoreductase from Zymomonas mobilis: an osmoprotective periplasmic enzyme containing non-dissociable NADP.
Structure (London, England : 1993) 1996;4(12):1413-28.
-
1996: Faber H R; Baker C J; Day C L; Tweedie J W; Baker E N
Mutation of arginine 121 in lactoferrin destabilizes iron binding by disruption of anion binding: crystal structures of R121S and R121E mutants.
Biochemistry 1996;35(46):14473-9.
-
1996: Baker H M; Anderson B F; Brodie A M; Shongwe M S; Smith C A; Baker E N
Anion binding by transferrins: importance of second-shell effects revealed by the crystal structure of oxalate-substituted diferric lactoferrin.
Biochemistry 1996;35(28):9007-13.
-
1996: Bewley M C; Lott J S; Baker E N; Patchett M L
The cloning, expression and crystallisation of a thermostable arginase.
FEBS letters 1996;386(2-3):215-8.
-
1996: Dobbs A J; Anderson B F; Faber H R; Baker E N
Three-dimensional structure of cytochrome c' from two Alcaligenes species and the implications for four-helix bundle structures.
Acta crystallographica. Section D, Biological crystallography 1996;52(Pt 2):356-68.
-
1996: Faber H R; Bland T; Day C L; Norris G E; Tweedie J W; Baker E N
Altered domain closure and iron binding in transferrins: the crystal structure of the Asp60Ser mutant of the amino-terminal half-molecule of human lactoferrin.
Journal of molecular biology 1996;256(2):352-63.
-
1996: Brown R L; Baker H M; Jameson G B; Scopes R K; Baker E N
Crystallization and preliminary X-ray diffraction studies of a cobalt-substituted derivative of the iron-dependent alcohol dehydrogenase from Zymomonas mobilis.
Acta crystallographica. Section D, Biological crystallography 1996;52(Pt 1):218-20.
-
1995: Smith C A; Pratchett M L; Baker E N
Crystallization and preliminary X-ray diffraction studies of arginase from a thermophilic organism Bacillus caldevelox.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 5):840-1.
-
1995: Haridas M; Anderson B F; Baker E N
Structure of human diferric lactoferrin refined at 2.2 A resolution.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 5):629-46.
-
1995: Faber H R; Groom C R; Baker H M; Morgan W T; Smith A; Baker E N
1.8 A crystal structure of the C-terminal domain of rabbit serum haemopexin.
Structure (London, England : 1993) 1995;3(6):551-9.
-
1995: Baker E N; Anderson B F; Dobbs A J; Dodson E J
Use of iron anomalous scattering with multiple models and data sets to identify and refine a weak molecular replacement solution: structure analysis of cytochrome c' from two bacterial species.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 3):282-9.
-
1995: Baker H M; Brown R L; Dobbs A J; Kitson K E; Kitson T M; Baker E N
Crystallization of sheep liver cytosolic aldehyde dehydrogenase in a form suitable for high resolution X-ray structural analysis.
Advances in experimental medicine and biology 1995;372():67-70.
-
1994: Norris G E; Stillman T J; Anderson B F; Baker E N
The three-dimensional structure of PNGase F, a glycosylasparaginase from Flavobacterium meningosepticum.
Structure (London, England : 1993) 1994;2(11):1049-59.
-
1994: Norris G E; Flaus A J; Moore C H; Baker E N
Purification and crystallization of the endoglycosidase PNGase F, a peptide:N-glycosidase from Flavobacterium meningosepticum.
Journal of molecular biology 1994;241(4):624-6.
-
1994: Baker H M; Brown R L; Dobbs A J; Blackwell L F; Buckley P D; Hardman M J; Hill J P; Kitson K E; Kitson T M; Baker E N
Crystallization and preliminary X-ray diffraction studies on cytosolic (class 1) aldehyde dehydrogenase from sheep liver.
Journal of molecular biology 1994;241(2):263-4.
-
1994: Kingston R L; Baker H M; Baker E N
Search designs for protein crystallization based on orthogonal arrays.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 4):429-40.
-
1994: Baker H M; Day C L; Norris G E; Baker E N
Enzymatic deglycosylation as a tool for crystallization of mammalian binding proteins.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 4):380-4.
-
1994: Smith C A; Anderson B F; Baker H M; Baker E N
Structure of copper- and oxalate-substituted human lactoferrin at 2.0 A resolution.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 3):302-16.
-
1994: Blackwell K A; Andersen B F; Baker E N
Metal substitution in a blue-copper protein: the crystal structure of cadmium-azurin at 1.8 A resolution.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 3):263-70.
-
1994: Brodie A M; Ainscough E W; Baker E N; Baker H M; Shongwe M S; Smith C A
Synergism and substitution in the lactoferrins.
Advances in experimental medicine and biology 1994;357():33-44.
-
1994: Smith C A; Baker H M; Shongwe M S; Anderson B F; Baker E N
Crystallographic studies on metal and anion substituted human lactoferrin.
Advances in experimental medicine and biology 1994;357():265-9.
-
1994: Sheth B; Stowell K M; Day C L; Baker E N; Tweedie J W
Cloning and expression of the C-terminal lobe of human lactoferrin.
Advances in experimental medicine and biology 1994;357():259-63.
-
1994: Haridas M; Anderson B F; Baker H M; Norris G E; Baker E N
X-ray structural analysis of bovine lactoferrin at 2.5 A resolution.
Advances in experimental medicine and biology 1994;357():235-8.
-
1994: Anderson B F; Norris G E; Rumball S V; Thomas D H; Baker E N
A comparison of the three-dimensional structures of human lactoferrin in its iron free and iron saturated forms.
Advances in experimental medicine and biology 1994;357():227-30.
-
1994: Baker E N; Anderson B F; Baker H M; Day C L; Haridas M; Norris G E; Rumball S V; Smith C A; Thomas D H
Three-dimensional structure of lactoferrin in various functional states.
Advances in experimental medicine and biology 1994;357():1-12.
-
1993: Gerstein M; Anderson B F; Norris G E; Baker E N; Lesk A M; Chothia C
Domain closure in lactoferrin. Two hinges produce a see-saw motion between alternative close-packed interfaces.
Journal of molecular biology 1993;234(2):357-72.
-
1993: Day C L; Anderson B F; Tweedie J W; Baker E N
Structure of the recombinant N-terminal lobe of human lactoferrin at 2.0 A resolution.
Journal of molecular biology 1993;232(4):1084-100.
-
1993: Shepard W E; Kingston R L; Anderson B F; Baker E N
Structure of apo-azurin from Alcaligenes denitrificans at 1.8 A resolution.
Acta crystallographica. Section D, Biological crystallography 1993;49(Pt 3):331-43.
-
1993: Baker H M; Norris G E; Morgan W T; Smith A; Baker E N
Crystallization of the C-terminal domain of rabbit serum hemopexin.
Journal of molecular biology 1993;229(1):251-2.
-
1992: Day C L; Norris G E; Anderson B F; Tweedie J W; Baker E N
Preliminary crystallographic studies of the amino terminal half of human lactoferrin in its iron-saturated and iron-free forms.
Journal of molecular biology 1992;228(3):973-4.
-
1992: Day C L; Stowell K M; Baker E N; Tweedie J W
Studies of the N-terminal half of human lactoferrin produced from the cloned cDNA demonstrate that interlobe interactions modulate iron release.
The Journal of biological chemistry 1992;267(20):13857-62.
-
1992: Smith C A; Anderson B F; Baker H M; Baker E N
Metal substitution in transferrins: the crystal structure of human copper-lactoferrin at 2.1-A resolution.
Biochemistry 1992;31(18):4527-33.
-
1992: Shongwe M S; Smith C A; Ainscough E W; Baker H M; Brodie A M; Baker E N
Anion binding by human lactoferrin: results from crystallographic and physicochemical studies.
Biochemistry 1992;31(18):4451-8.
-
1992: Baker E N; Baker H M; Smith C A; Stebbins M R; Kahn M; Hellström K E; Hellström I
Human melanotransferrin (p97) has only one functional iron-binding site.
FEBS letters 1992;298(2-3):215-8.
-
1991: Norris G E; Anderson B F; Baker E N
Molecular replacement solution of the structure of apolactoferrin, a protein displaying large-scale conformational change.
Acta crystallographica. Section B, Structural science 1991;47 ( Pt 6)():998-1004.
-
1991: Baker E N; Anderson B F; Baker H M; Haridas M; Jameson G B; Norris G E; Rumball S V; Smith C A
Structure, function and flexibility of human lactoferrin.
International journal of biological macromolecules 1991;13(3):122-9.
-
1991: Smith C A; Baker H M; Baker E N
Preliminary crystallographic studies of copper(II)- and oxalate-substituted human lactoferrin.
Journal of molecular biology 1991;219(2):155-9.
-
1990: Anderson B F; Baker H M; Norris G E; Rumball S V; Baker E N
Apolactoferrin structure demonstrates ligand-induced conformational change in transferrins.
Nature 1990;344(6268):784-7.
-
1989: Anderson B F; Baker H M; Norris G E; Rice D W; Baker E N
Structure of human lactoferrin: crystallographic structure analysis and refinement at 2.8 A resolution.
Journal of molecular biology 1989;209(4):711-34.
-
1989: Norris G E; Baker H M; Baker E N
Preliminary crystallographic studies on human apo-lactoferrin in its native and deglycosylated forms.
Journal of molecular biology 1989;209(2):329-31.
-
1988: Baker E N
Structure of azurin from Alcaligenes denitrificans refinement at 1.8 A resolution and comparison of the two crystallographically independent molecules.
Journal of molecular biology 1988;203(4):1071-95.
-
1987: Anderson B F; Baker H M; Dodson E J; Norris G E; Rumball S V; Waters J M; Baker E N
Structure of human lactoferrin at 3.2-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(7):1769-73.
-
1987: Ainscough E W; Bingham A G; Brodie A M; Ellis W R; Gray H B; Loehr T M; Plowman J E; Norris G E; Baker E N
Spectrochemical studies on the blue copper protein azurin from Alcaligenes denitrificans.
Biochemistry 1987;26(1):71-82.
-
1986: Norris G E; Anderson B F; Baker E N; Baker H M; Gärtner A L; Ward J; Rumball S V
Preliminary crystallographic studies on bovine lactoferrin.
Journal of molecular biology 1986;191(1):143-5.
-
1983: Norris G E; Anderson B F; Baker E N
Structure of azurin from Alcaligenes denitrificans at 2.5 A resolution.
Journal of molecular biology 1983;165(3):501-21.
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