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Jørgen Kjems

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TOP 3
Thomas B Hansen; Trine I Jensen; Jesper B Bramsen; Bettina H Clausen; Christian K Damgaard; Bente Finsen; Jørgen Kjems
Natural RNA circles function as efficient microRNA sponges.
Zsuzsanna Sükösd; M Shel Swenson; Jørgen Kjems; Christine E Heitsch
Evaluating the accuracy of SHAPE-directed RNA secondary structure predictions.
Elaheh Farjami; Kurt V Gothelf; Jørgen Kjems; Jesper S Nielsen; Rui Campos; Elena E Ferapontova
RNA aptamer-based electrochemical biosensor for selective and label-free analysis of dopamine.

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All Publications

2013: Thomas B Hansen; Trine I Jensen; Jesper B Bramsen; Bettina H Clausen; Christian K Damgaard; Bente Finsen; Jørgen Kjems
Natural RNA circles function as efficient microRNA sponges.
Nature 2013;495(7441):384-8.
2013: Zsuzsanna Sükösd; M Shel Swenson; Jørgen Kjems; Christine E Heitsch
Evaluating the accuracy of SHAPE-directed RNA secondary structure predictions.
Nucleic acids research 2013;41(5):2807-16.
2013: Elaheh Farjami; Kurt V Gothelf; Jørgen Kjems; Jesper S Nielsen; Rui Campos; Elena E Ferapontova
RNA aptamer-based electrochemical biosensor for selective and label-free analysis of dopamine.
Analytical chemistry 2013;85(1):121-8.
2013: Frank Iversen; Jørgen Kjems; David H Schaffert; Chuanxu Yang; Frederik Dagnaes-Hansen; Shan Gao
Optimized siRNA-PEG conjugates for extended blood circulation and reduced urine excretion in mice.
Theranostics 2013;3(3):201-9.
2013: Borja Ballarín-González; Frederik Dagnaes-Hansen; Mingdong Dong; Robert A Fenton; Shan Gao; San Hein; Jørgen Kjems; Kenneth A Howard
Protection and Systemic Translocation of siRNA Following Oral Administration of Chitosan/siRNA Nanoparticles.
Molecular therapy. Nucleic acids 2013;2():e76.
2013: Zsuzsanna Sükösd; James W J Anderson; Jørgen Kjems; Bjarne Knudsen; Adám Novák; Christian N S Pedersen
Characterising RNA secondary structure space using information entropy.
BMC bioinformatics 2013;14 Suppl 2():S22.
2013: Jesper B Bramsen; Jørgen Kjems
Engineering small interfering RNAs by strategic chemical modification.
Methods in molecular biology (Clifton, N.J.) 2013;942():87-109.
2012: Reza M Zadegan; Anders H Okholm; David H Schaffert; Karen E Thomsen; Ebbe Sloth Andersen; Victoria Birkedal; Mette D E Jepsen; Jørgen Kjems
Construction of a 4 zeptoliters switchable 3D DNA box origami.
ACS nano 2012;6(11):10050-3.
2012: Zsuzsanna Sükösd; Jørgen Kjems; Bjarne Knudsen; Christian N S Pedersen
PPfold 3.0: fast RNA secondary structure prediction using phylogeny and auxiliary data.
Bioinformatics (Oxford, England) 2012;28(20):2691-2.
2012: Chammiran Daniel; Ylva Ekdahl; Jørgen Kjems; Morten T Venø; Marie Ohman
A distant cis acting intronic element induces site-selective RNA editing.
Nucleic acids research 2012;40(19):9876-86.
2012: Morten T Venø; Christian Bendixen; Jesper B Bramsen; Frank Panitz; Ida Elisabeth Holm; Marie Öhman; Jørgen Kjems
Spatio-temporal regulation of ADAR editing during development in porcine neural tissues.
RNA biology 2012;9(8):1054-65.
2012: Menglin Chen; Mingdong Dong; Shan Gao; Kenneth A Howard; Jørgen Kjems; Jie Song; Chuanxu Yang; Flemming Besenbacher
Chitosan/siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery.
ACS nano 2012;6(6):4835-44.
2012: Guy Wayne Novotny; Ewa Rajpert-De Meyts; Si Brask Sonne; John E Nielsen; Kristian Almstrup; Kirstine C Belling; Jette Bork-Jensen; Jesper Bertram Bramsen; Jørgen Kjems; Henrik Leffers
MicroRNA expression profiling of carcinoma in situ cells of the testis.
Endocrine-related cancer 2012;19(3):365-79.
2012: Brian Dall Schyth; Jesper Wengel; Malgorzata Maria Pakula; Jesper Bertram Bramsen; Jørgen Kjems; Sekar Larashati; Niels Lorenzen
In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important.
Nucleic acids research 2012;40(10):4653-65.
2012: Esben Kjær Unmack Larsen; Arcot R Lokanathan; Niels Chr Nielsen; Thomas Nielsen; Louise Munk Rydtoft; Thomas Wittenborn; Leif Ostergaard; Flemming Besenbacher; Line Hansen; Kenneth A Howard; Peter Kingshott; Jørgen Kjems
Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors.
Nanoscale 2012;4(7):2352-61.
2012: Luisa Montanini; Alba Murgia; Chiara Novello; Laura Pazzaglia; Roberto Perris; Amalia Conti; Søren Peter Jonstrup; Jørgen Kjems; Lisa Lasagna; Valeria Barili; Maria Serena Benassi
MicroRNA cloning and sequencing in osteosarcoma cell lines: differential role of miR-93.
Cellular oncology (Dordrecht) 2012;35(1):29-41.
2012: Jesper B Bramsen; Jørgen Kjems
Development of Therapeutic-Grade Small Interfering RNAs by Chemical Engineering.
Frontiers in genetics 2012;3():154.
2012: Stig Mølgaard Rask Jensen; Jørgen Kjems; Finn Skou Pedersen; Alexander Schmitz; Jesper Bertram Bramsen
Functional selection of shRNA loops from randomized retroviral libraries.
PloS one 2012;7(8):e43095.
2011: Thomas B Hansen; Jesper B Bramsen; Susan J Clark; Aaron L Statham; Sune B Villadsen; Erik D Wiklund; Jørgen Kjems
miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA.
The EMBO journal 2011;30(21):4414-22.
2011: Miao Yu; Henkjan Gersen; Lev N Kantorovich; R E A Kelly; Jørgen Kjems; Erik Laegsgaard; Trolle R Linderoth; Qiang-qiang Meng; Manuela Mura; Ivan Stensgaard; Jianguo Wang; Wei Xu; Flemming Besenbacher
Homochiral xanthine quintet networks self-assembled on Au(111) surfaces.
ACS nano 2011;5(8):6651-60.
2011: Victoria Birkedal; Mingdong Dong; Monika M Golas; Kurt V Gothelf; Ebbe Sloth Andersen; Flemming Besenbacher; Bjoern Sander; Jørgen Kjems
Single molecule microscopy methods for the study of DNA origami structures.
Microscopy research and technique 2011;74(7):688-98.
2011: Thomas B Hansen; Jørgen Kjems; Jesper B Bramsen
Enhancing miRNA annotation confidence in miRBase by continuous cross dataset analysis.
RNA biology 2011;8(3):378-83.
2011: Kasper Jahn; Thomas Tørring; Niels Vinther Voigt; Rasmus Schøler Sørensen; Anne Louise Bank Kodal; Ebbe Sloth Andersen; Kurt V Gothelf; Jørgen Kjems
Functional patterning of DNA origami by parallel enzymatic modification.
Bioconjugate chemistry 2011;22(4):819-23.
2011: Zhao Zhang; Eva M Olsen; Mille Kryger; Niels V Voigt; Thomas Tørring; Eda Gültekin; Morten Nielsen; Reza MohammadZadegan; Ebbe Sloth Andersen; Morten Muhlig Nielsen; Jørgen Kjems; Victoria Birkedal; Kurt V Gothelf
A DNA tile actuator with eleven discrete states.
Angewandte Chemie (International ed. in English) 2011;50(17):3983-7.
2011: Erik D Wiklund; Jesper B Bramsen; Toby Hulf; Lars Dyrskjøt; Ramshanker Ramanathan; Thomas B Hansen; Sune B Villadsen; Shan Gao; Marie S Ostenfeld; Michael Borre; Marcus E Peter; Torben F Ørntoft; Jørgen Kjems; Susan J Clark
Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer.
International journal of cancer. Journal international du cancer 2011;128(6):1327-34.
2011: Kasper Jahn; Eva Maria Olsen; Morten Muhlig Nielsen; Thomas Tørring; Reza MohammadZadegan; Ebbe Sloth Andersen; Kurt V Gothelf; Jørgen Kjems
Site-specific chemical labeling of long RNA molecules.
Bioconjugate chemistry 2011;22(1):95-100.
2011: Erik D Wiklund; Vivi Bakholdt; Jesper B Bramsen; Susan J Clark; Daniela Elena Costea; Shan Gao; Toby Hulf; Annelise Krogdahl; Shalima Nair; Tennille Sibbritt; Jens Ahm Sørensen; Sune B Villadsen; Jørgen Kjems
MicroRNA alterations and associated aberrant DNA methylation patterns across multiple sample types in oral squamous cell carcinoma.
PloS one 2011;6(11):e27840.
2011: Zsuzsanna Sükösd; Bjarne Knudsen; Morten Vaerum; Jørgen Kjems; Ebbe S Andersen
Multithreaded comparative RNA secondary structure prediction using stochastic context-free grammars.
BMC bioinformatics 2011;12():103.
2011: Jesper B Bramsen; Jørgen Kjems
Chemical modification of small interfering RNA.
Methods in molecular biology (Clifton, N.J.) 2011;721():77-103.
2011: Martin Lützelberger; Jørgen Kjems
S1 nuclease analysis of alternatively spliced mRNA.
Methods in molecular biology (Clifton, N.J.) 2011;703():161-71.
2010: Wei Xu; Jian-Guo Wang; Mikkel F Jacobsen; Manuela Mura; Miao Yu; R E A Kelly; Qiang-Qiang Meng; Erik Laegsgaard; Ivan Stensgaard; Trolle R Linderoth; Jørgen Kjems; Lev N Kantorovich; Kurt V Gothelf; Flemming Besenbacher
Supramolecular porous network formed by molecular recognition between chemically modified nucleobases guanine and cytosine.
Angewandte Chemie (International ed. in English) 2010;49(49):9373-7.
2010: Erik D Wiklund; Jørgen Kjems; Susan J Clark
Epigenetic architecture and miRNA: reciprocal regulators.
Epigenomics 2010;2(6):823-40.
2010: Ulrik L Rahbek; Anne F Nielsen; Mingdong Dong; Yezi You; Anne Chauchereau; David Oupický; Flemming Besenbacher; Jørgen Kjems; Kenneth A Howard
Bioresponsive hyperbranched polymers for siRNA and miRNA delivery.
Journal of drug targeting 2010;18(10):812-20.
2010: Ebbe J B Nielsen; Jan M Nielsen; Daniel Becker; Alexander Karlas; Hridayesh Prakash; Sys Z Glud; Jonathan Merrison; Flemming Besenbacher; Thomas F Meyer; Jørgen Kjems; Kenneth A Howard
Pulmonary gene silencing in transgenic EGFP mice using aerosolised chitosan/siRNA nanoparticles.
Pharmaceutical research 2010;27(12):2520-7.
2010: Christophe K Mapendano; Søren Lykke-Andersen; Jørgen Kjems; Edouard Bertrand; Torben Heick Jensen
Crosstalk between mRNA 3' end processing and transcription initiation.
Molecular cell 2010;40(3):410-22.
2010: Morten Ø Andersen; Jens V Nygaard; Jorge S Burns; Merete K Raarup; Jens R Nyengaard; Cody Bünger; Flemming Besenbacher; Kenneth A Howard; Moustapha Kassem; Jørgen Kjems
siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(11):2018-27.
2010: Jesper B Bramsen; Malgorzata M Pakula; Thomas B Hansen; Claus Bus; Niels Langkjær; Dalibor Odadzic; Romualdas Smicius; Suzy L Wengel; Jyoti Chattopadhyaya; Joachim W Engels; Piet Herdewijn; Jesper Wengel; Jørgen Kjems
A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects.
Nucleic acids research 2010;38(17):5761-73.
2010: Jan Mollenhauer; Dimitrios Stamou; Allan Flyvbjerg; Jesper Wengel; Ulrik Gether; Jørgen Kjems; Thomas Bjørnholm; Flemming Besenbacher
David versus Goliath.
Nanomedicine : nanotechnology, biology, and medicine 2010;6(4):504-9.
2010: A C Krüger; M K Raarup; M M Nielsen; M Kristensen; Flemming Besenbacher; Jørgen Kjems; V Birkedal
Interaction of hnRNP A1 with telomere DNA G-quadruplex structures studied at the single molecule level.
European biophysics journal : EBJ 2010;39(9):1343-50.
2010: Morten Ø Andersen; Agata Lichawska; Ayyoob Arpanaei; Stig Møller Rask Jensen; Harpreet Kaur; David Oupický; Flemming Besenbacher; Peter Kingshott; Jørgen Kjems; Kenneth A Howard
Surface functionalisation of PLGA nanoparticles for gene silencing.
Biomaterials 2010;31(21):5671-7.
2010: Jeppe B Madsen; marc dupont; Thomas B Andersen; Anne F Nielsen; Lu Sang; Ditte M Brix; Jan K Jensen; Thomas Broos; Maarten L V Hendrickx; Anni Christensen; Jørgen Kjems; Peter A Andreasen
RNA aptamers as conformational probes and regulatory agents for plasminogen activator inhibitor-1.
Biochemistry 2010;49(19):4103-15.
2010: Maria B Laursen; Malgorzata M Pakula; Shan Gao; Kees Fluiter; Olaf R Mook; Frank Baas; Niels Langklaer; Suzy L Wengel; Jesper Wengel; Jørgen Kjems; Jesper B Bramsen
Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo.
Molecular bioSystems 2010;6(5):862-70.
2010: Niels V Voigt; Thomas Tørring; Alexandru Rotaru; Mikkel F Jacobsen; Jens B Ravnsbaek; Ramesh Subramani; Wael Mamdouh; Jørgen Kjems; Andriy Mokhir; Flemming Besenbacher; Kurt V Gothelf
Single-molecule chemical reactions on DNA origami.
Nature nanotechnology 2010;5(3):200-3.
2010: Martin Bjerregård Pedersen; Xingfei Zhou; Esben Kjaer Unmack Larsen; Uffe Skov Sørensen; Jørgen Kjems; Jens Vinge Nygaard; Jens Randel Nyengaard; Rikke Louise Meyer; Thomas Boesen; Thomas Vorup-Jensen
Curvature of synthetic and natural surfaces is an important target feature in classical pathway complement activation.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(4):1931-45.
2010: Thomas Birkballe Hansen; Jesper Bertram Bramsen; Jørgen Kjems
Re-inspection of small RNA sequence datasets reveals several novel human miRNA genes.
PloS one 2010;5(6):e10961.
2009: Jesper Pallesen; Mingdong Dong; Flemming Besenbacher; Jørgen Kjems
Structure of the HIV-1 Rev response element alone and in complex with regulator of virion (Rev) studied by atomic force microscopy.
The FEBS journal 2009;276(15):4223-32.
2009: Esben K U Larsen; Thomas Nielsen; Thomas Wittenborn; Henrik Birkedal; Thomas Vorup-Jensen; Mogens H Jakobsen; Leif Ostergaard; Michael R Horsman; Flemming Besenbacher; Kenneth A Howard; Jørgen Kjems
Size-Dependent Accumulation of PEGylated Silane-Coated Magnetic Iron Oxide Nanoparticles in Murine Tumors.
ACS nano 2009;3(7):1947-51.
2009: Shan Gao; Frederik Dagnaes-Hansen; Ebbe Juel Bech Nielsen; Jesper Wengel; Flemming Besenbacher; Kenneth A Howard; Jørgen Kjems
The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(7):1225-33.
2009: Ebbe S Andersen; Mingdong Dong; Morten M Nielsen; Kasper Jahn; Ramesh Subramani; Wael Mamdouh; Monika M Golas; Bjoern Sander; Holger Stark; Cristiano L P Oliveira; Jan Skov Pedersen; Victoria Birkedal; Flemming Besenbacher; Kurt V Gothelf; Jørgen Kjems
Self-assembly of a nanoscale DNA box with a controllable lid.
Nature 2009;459(7243):73-6.
2009: Morten Østergaard Andersen; Kenneth Alan Howard; Jørgen Kjems
RNAi using a chitosan/siRNA nanoparticle system: in vitro and in vivo applications.
Methods in molecular biology (Clifton, N.J.) 2009;555():77-86.
2009: Kenneth A Howard; Søren R Paludan; Mark A Behlke; Flemming Besenbacher; Bent Deleuran; Jørgen Kjems
Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(1):162-8.
2008: Irina V Astakhova; Vladimir A Korshun; Kasper Jahn; Jørgen Kjems; Jesper Wengel
Perylene attached to 2'-amino-LNA: synthesis, incorporation into oligonucleotides, and remarkable fluorescence properties in vitro and in cell culture.
Bioconjugate chemistry 2008;19(10):1995-2007.
2008: J V Nygaard; Morten Ø Andersen; Kenneth A Howard; M Foss; Cody Bünger; Jørgen Kjems; Flemming Besenbacher
Investigation of particle-functionalized tissue engineering scaffolds using X-ray tomographic microscopy.
Biotechnology and bioengineering 2008;100(4):820-9.
2008: Ebbe S Andersen; Mingdong Dong; Morten M Nielsen; Kasper Jahn; Allan Lind-Thomsen; Wael Mamdouh; Kurt V Gothelf; Flemming Besenbacher; Jørgen Kjems
DNA origami design of dolphin-shaped structures with flexible tails.
ACS nano 2008;2(6):1213-8.
2008: Christian K Damgaard; Søren Kahns; Søren Lykke-Andersen; Anders Lade Nielsen; Torben Heick Jensen; Jørgen Kjems
A 5' splice site enhances the recruitment of basal transcription initiation factors in vivo.
Molecular cell 2008;29(2):271-8.
2008: Elfar Torarinsson; Zizhen Yao; Eric D Wiklund; Jesper B Bramsen; Claus Hansen; Jørgen Kjems; Niels Tommerup; Walter L Ruzzo; Jan Gorodkin
Comparative genomics beyond sequence-based alignments: RNA structures in the ENCODE regions.
Genome research 2008;18(2):242-51.
2008: Morten Ø Andersen; Kenneth A Howard; Søren R Paludan; Flemming Besenbacher; Jørgen Kjems
Delivery of siRNA from lyophilized polymeric surfaces.
Biomaterials 2008;29(4):506-12.
2008: Roberto Otero; Wei Xu; Maya Lukas; R E A Kelly; Erik Laegsgaard; Ivan Stensgaard; Jørgen Kjems; Lev N Kantorovich; Flemming Besenbacher
Specificity of watson-crick base pairing on a solid surface studied at the atomic scale.
Angewandte Chemie (International ed. in English) 2008;47(50):9673-6.
2008: Ulrik Lytt Rahbek; Kenneth A Howard; David Oupický; Devika S Manickam; Dong Mingdong; Anne F Nielsen; Thomas B Hansen; Flemming Besenbacher; Jørgen Kjems
Intracellular siRNA and precursor miRNA trafficking using bioresponsive copolypeptides.
The journal of gene medicine 2008;10(1):81-93.
2008: Dalibor Odadzic; Jesper B Bramsen; Romualdas Smicius; Claus Bus; Jørgen Kjems; Joachim W Engels
Synthesis of 2'-O-modified adenosine building blocks and application for RNA interference.
Bioorganic & medicinal chemistry 2008;16(1):518-29.
2007: Kenneth A Howard; Jørgen Kjems
Polycation-based nanoparticle delivery for improved RNA interference therapeutics.
Expert opinion on biological therapy 2007;7(12):1811-22.
2007: Ebbe Sloth Andersen; Allan Lind-Thomsen; Bjarne Knudsen; Susie E Kristensen; Jakob H Havgaard; Elfar Torarinsson; Niels Larsen; Christian Zwieb; Peter Sestoft; Jørgen Kjems; Jan Gorodkin
Semiautomated improvement of RNA alignments.
RNA (New York, N.Y.) 2007;13(11):1850-9.
2007: Søren Lykke-Andersen; Serafín Piñol-Roma; Jørgen Kjems
Alternative splicing of the ADAR1 transcript in a region that functions either as a 5'-UTR or an ORF.
RNA (New York, N.Y.) 2007;13(10):1732-44.
2007: Sailong Xu; Dong Mingdong; Xiudong Liu; Kenneth A Howard; Jørgen Kjems; Flemming Besenbacher
Direct force measurements between siRNA and chitosan molecules using force spectroscopy.
Biophysical journal 2007;93(3):952-9.
2007: G W Novotny; Si Brask Sonne; John E Nielsen; Søren Peter Jonstrup; Martin A Hansen; Niels E Skakkebaek; Ewa Rajpert-De Meyts; Jørgen Kjems; Henrik Leffers
Translational repression of E2F1 mRNA in carcinoma in situ and normal testis correlates with expression of the miR-17-92 cluster.
Cell death and differentiation 2007;14(4):879-82.
2007: Karsten Bork Nielsen; Suzette Sørensen; Luca Cartegni; Thomas J Corydon; Thomas Koed Doktor; Lisbeth Dahl Schroeder; Line Sinnathamby Reinert; Orly Elpeleg; Adrian R Krainer; Niels Gregersen; Jørgen Kjems; Brage S Andresen
Seemingly neutral polymorphic variants may confer immunity to splicing-inactivating mutations: a synonymous SNP in exon 5 of MCAD protects from deleterious mutations in a flanking exonic splicing enhancer.
American journal of human genetics 2007;80(3):416-32.
2007: Xiudong Liu; Kenneth A Howard; Dong Mingdong; Morten Ø Andersen; Ulrik Lytt Rahbek; Mads G Johnsen; Ole C Hansen; Flemming Besenbacher; Jørgen Kjems
The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing.
Biomaterials 2007;28(6):1280-8.
2007: Jesper B Bramsen; Maria B Laursen; Christian K Damgaard; Suzy W Lena; B Ravindra Babu; Jesper Wengel; Jørgen Kjems
Improved silencing properties using small internally segmented interfering RNAs.
Nucleic acids research 2007;35(17):5886-97.
2007: Martin R Jakobsen; Martin Roelsgaard Jakobsen; Jesper Wengel; Ben Berkhout; Jørgen Kjems
Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites.
Retrovirology 2007;4():29.
2007: Kenneth A Howard; Dong Mingdong; David Oupický; Harender S Bisht; Claus Buss; Flemming Besenbacher; Jørgen Kjems
Nanocarrier stimuli-activated gene delivery.
Small (Weinheim an der Bergstrasse, Germany) 2007;3(1):54-7.
2006: Kenneth A Howard; Ulrik Lytt Rahbek; Xiudong Liu; Christian K Damgaard; Sys Zoffmann Glud; Morten Ø Andersen; Mads Bruun Hovgaard; Alexander Schmitz; Jens R Nyengaard; Flemming Besenbacher; Jørgen Kjems
RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(4):476-84.
2006: Søren Peter Jonstrup; Jørn Koch; Jørgen Kjems
A microRNA detection system based on padlock probes and rolling circle amplification.
RNA (New York, N.Y.) 2006;12(9):1747-52.
2006: Martin Lützelberger; Line S Reinert; Atze T Das; Ben Berkhout; Jørgen Kjems
A novel splice donor site in the gag-pol gene is required for HIV-1 RNA stability.
The Journal of biological chemistry 2006;281(27):18644-51.
2006: Rajesh Mohey; Martin Tolstrup; Louise B Jørgensen; Bjarne Møller; Finn T Black; Jørgen Kjems; Niels Obel
HIV-1 reverse transcriptase gene 103K/N and 184M/V combinations in tandem: detection and quantification of HIV-1 populations in the CD45RO+ T-cell compartment by a double-ARMS real-time PCR assay.
Journal of acquired immune deficiency syndromes (1999) 2006;41(2):160-7.
2006: Susanne Kammler; Marianne Otte; Ilona Hauber; Jørgen Kjems; Joachim Hauber; Heiner Schaal
The strength of the HIV-1 3' splice sites affects Rev function.
Retrovirology 2006;3():89.
2006: Rajesh Mohey; Terese L Katzenstein; Finn T Black; Jørgen Kjems; Niels Obel
Dynamics of proviral HIV-1 184M/V in circulating CD4+ T-cells: a 90 days follow-up study after initiation/switch of HAART.
Scandinavian journal of infectious diseases 2006;38(2):119-23.
2006: Saowakon Paca-Uccaralertkun; Christian K Damgaard; Prasert Auewarakul; Arunee Thitithanyanont; Pirada Suphaphiphat; Max Essex; Jørgen Kjems; Tun-Hou Lee
The Effect of a Single Nucleotide Substitution in the Splicing Silencer in the tat/rev Intron on HIV Type 1 Envelope Expression.
AIDS research and human retroviruses 2006;22(1):76-82.
2005: Rupa Mukhopadhyay; Vadim V Sumbayev; Martin Lorentzen; Jørgen Kjems; Peter A Andreasen; Flemming Besenbacher
Cantilever sensor for nanomechanical detection of specific protein conformations.
Nano letters 2005;5(12):2385-8.
2005: Rajesh Mohey; Louise B Jørgensen; Bjarne Møller; Finn T Black; Jørgen Kjems; Niels Obel
Detection and quantification of proviral HIV-1 184 M/V in circulating CD4(+) T cells of patients on HAART with a viremia less than 1,000 copies/ml.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2005;34(4):257-67.
2005: R Mukhopadhyay; M Lorentzen; Jørgen Kjems; Flemming Besenbacher
Nanomechanical sensing of DNA sequences using piezoresistive cantilevers.
Langmuir : the ACS journal of surfaces and colloids 2005;21(18):8400-8.
2005: Morten Nielsen; Vita Dauksaite; Jørgen Kjems; Kurt V Gothelf
DNA-directed coupling of organic modules by multiple parallel reductive aminations and subsequent cleavage of selected DNA sequences.
Bioconjugate chemistry 2005;16(4):981-5.
2005: Clemens Furnes; Thomas Arnesen; Peter Askjaer; Jørgen Kjems; Anne Marie Szilvay
HIV-1 Rev oligomerization is not obligatory in the presence of an extra basic domain.
Retrovirology 2005;2():39.
2005: Morten Hjuler Nielsen; Finn Skou Pedersen; Jørgen Kjems
Molecular strategies to inhibit HIV-1 replication.
Retrovirology 2005;2():10.
2004: Bjarne Knudsen; Ebbe Sloth Andersen; Christian K Damgaard; Jørgen Kjems; Jan Gorodkin
Evolutionary rate variation and RNA secondary structure prediction.
Computational biology and chemistry 2004;28(3):219-26.
2004: Ebbe Sloth Andersen; Sonia Antoranz Contera; Bjarne Knudsen; Christian K Damgaard; Flemming Besenbacher; Jørgen Kjems
Role of the trans-activation response element in dimerization of HIV-1 RNA.
The Journal of biological chemistry 2004;279(21):22243-9.
2004: Alan M Zahler; Christian K Damgaard; Jørgen Kjems; Massimo Caputi
SC35 and heterogeneous nuclear ribonucleoprotein A/B proteins bind to a juxtaposed exonic splicing enhancer/exonic splicing silencer element to regulate HIV-1 tat exon 2 splicing.
The Journal of biological chemistry 2004;279(11):10077-84.
2004: Christian K Damgaard; Ebbe Sloth Andersen; Bjarne Knudsen; Jan Gorodkin; Jørgen Kjems
RNA interactions in the 5' region of the HIV-1 genome.
Journal of molecular biology 2004;336(2):369-79.
2004: Martin R Jakobsen; Martin Roelsgaard Jakobsen; Ebbe Sloth Andersen; Anna J Podhajska; Jørgen Kjems
A genomic selection strategy to identify accessible and dimerization blocking targets in the 5'-UTR of HIV-1 RNA.
Nucleic acids research 2004;32(7):e67.
2003: Marcel Freund; Corinna Asang; Susanne Kammler; Carolin Konermann; Jörg Krummheuer; Marianne Hipp; Imke Meyer; Wolfram Gierling; Stephan Theiss; Thorsten Preuss; Detlev Schindler; Jørgen Kjems; Heiner Schaal
A novel approach to describe a U1 snRNA binding site.
Nucleic acids research 2003;31(23):6963-75.
2003: Mario Köster; Søren Lykke-Andersen; Yasser A Elnakady; Klaus Gerth; Peter Washausen; Gerhard Höfle; Florenz Sasse; Jørgen Kjems; Hansjörg Hauser
Ratjadones inhibit nuclear export by blocking CRM1/exportin 1.
Experimental cell research 2003;286(2):321-31.
2003: Ebbe Sloth Andersen; Rienk E Jeeninga; Christian K Damgaard; Ben Berkhout; Jørgen Kjems
Dimerization and template switching in the 5' untranslated region between various subtypes of human immunodeficiency virus type 1.
Journal of virology 2003;77(5):3020-30.
2002: Christian K Damgaard; Thomas Ostergaard Tange; Jørgen Kjems
hnRNP A1 controls HIV-1 mRNA splicing through cooperative binding to intron and exon splicing silencers in the context of a conserved secondary structure.
RNA (New York, N.Y.) 2002;8(11):1401-15.
2002: Dirk Daelemans; Elena Afonina; Jakob Nilsson; Gudrun Werner; Jørgen Kjems; Erik De Clercq; George Pavlakis; Anne-Mieke Vandamme
A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14440-5.
2002: Annette M G Dirac; Hendrik Huthoff; Jørgen Kjems; Ben Berkhout
Requirements for RNA heterodimerization of the human immunodeficiency virus type 1 (HIV-1) and HIV-2 genomes.
The Journal of general virology 2002;83(Pt 10):2533-42.
2002: Félicie Faucon Andersen; Thomas Ø Tange; Thayaline Sinnathamby; Jens R Olesen; Kirsten E Andersen; Ole Westergaard; Jørgen Kjems; Birgitta R Knudsen
The RNA splicing factor ASF/SF2 inhibits human topoisomerase I mediated DNA relaxation.
Journal of molecular biology 2002;322(4):677-86.
2002: Annette M G Dirac; Hendrik Huthoff; Jørgen Kjems; Ben Berkhout
Regulated HIV-2 RNA dimerization by means of alternative RNA conformations.
Nucleic acids research 2002;30(12):2647-55.
2002: Jakob Nilsson; Karsten Weis; Jørgen Kjems
The C-terminal extension of the small GTPase Ran is essential for defining the GDP-bound form.
Journal of molecular biology 2002;318(2):583-93.
2002: Susan Lindtner; Barbara K Felber; Jørgen Kjems
An element in the 3' untranslated region of human LINE-1 retrotransposon mRNA binds NXF1(TAP) and can function as a nuclear export element.
RNA (New York, N.Y.) 2002;8(3):345-56.
2002: Mette Lund; Jørgen Kjems
Defining a 5' splice site by functional selection in the presence and absence of U1 snRNA 5' end.
RNA (New York, N.Y.) 2002;8(2):166-79.
2001: H Poulsen; Jakob Nilsson; Christian K Damgaard; Jan Egebjerg; Jørgen Kjems
CRM1 mediates the export of ADAR1 through a nuclear export signal within the Z-DNA binding domain.
Molecular and cellular biology 2001;21(22):7862-71.
2001: Thomas Ostergaard Tange; Christian K Damgaard; S Guth; Juan Valcárcel; Jørgen Kjems
The hnRNP A1 protein regulates HIV-1 tat splicing via a novel intron silencer element.
The EMBO journal 2001;20(20):5748-58.
2001: Thomas Ø Tange; Jørgen Kjems
SF2/ASF binds to a splicing enhancer in the third HIV-1 tat exon and stimulates U2AF binding independently of the RS domain.
Journal of molecular biology 2001;312(4):649-62.
2001: Annette M G Dirac; Hendrik Huthoff; Jørgen Kjems; Ben Berkhout
The dimer initiation site hairpin mediates dimerization of the human immunodeficiency virus, type 2 RNA genome.
The Journal of biological chemistry 2001;276(34):32345-52.
2001: Susanne Kammler; Cordula Leurs; Marcel Freund; Jörg Krummheuer; K Seidel; Thomas Ostergaard Tange; M K Lund; Jørgen Kjems; A Scheid; Heiner Schaal
The sequence complementarity between HIV-1 5' splice site SD4 and U1 snRNA determines the steady-state level of an unstable env pre-mRNA.
RNA (New York, N.Y.) 2001;7(3):421-34.
2001: Annette M G Dirac; Jørgen Kjems
Mapping DNA-binding sites of HIV-1 integrase by protein footprinting.
European journal of biochemistry / FEBS 2001;268(3):743-51.
2001: Jakob Nilsson; Peter Askjaer; Jørgen Kjems
A role for the basic patch and the C terminus of RanGTP in regulating the dynamic interactions with importin beta, CRM1 and RanBP1.
Journal of molecular biology 2001;305(2):231-43.
2000: Peter Askjaer; R Rosendahl; Jørgen Kjems
Nuclear export of the DEAD box An3 protein by CRM1 is coupled to An3 helicase activity.
The Journal of biological chemistry 2000;275(16):11561-8.
2000: M Lund; Thomas Ostergaard Tange; H Dyhr-Mikkelsen; J Hansen; Jørgen Kjems
Characterization of human RNA splice signals by iterative functional selection of splice sites.
RNA (New York, N.Y.) 2000;6(4):528-44.
2000: Jørgen Kjems; Peter Askjaer
Rev protein and its cellular partners.
Advances in pharmacology (San Diego, Calif.) 2000;48():251-98.
1999: Peter Askjaer; A Bachi; Matthias Wilm; F Ralf Bischoff; D L Weeks; V Ogniewski; M Ohno; Christof Niehrs; Jørgen Kjems; Iain W Mattaj; Maarten Fornerod
RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase.
Molecular and cellular biology 1999;19(9):6276-85.
1998: Peter Askjaer; Torben Heick Jensen; Jakob Nilsson; L Englmeier; Jørgen Kjems
The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP.
The Journal of biological chemistry 1998;273(50):33414-22.
1998: Christian K Damgaard; H Dyhr-Mikkelsen; Jørgen Kjems
Mapping the RNA binding sites for human immunodeficiency virus type-1 gag and NC proteins within the complete HIV-1 and -2 untranslated leader regions.
Nucleic acids research 1998;26(16):3667-76.
1998: Peter Askjaer; Jørgen Kjems
Mapping of multiple RNA binding sites of human T-cell lymphotropic virus type I rex protein within 5'- and 3'-Rex response elements.
The Journal of biological chemistry 1998;273(19):11463-71.
1998: Jørgen Kjems; Jan Egebjerg
Modern methods for probing RNA structure.
Current opinion in biotechnology 1998;9(1):59-65.
1998: A Jensen; Torben Heick Jensen; Jørgen Kjems
HIV-1 rev nuclear export signal binding peptides isolated by phage display.
Journal of molecular biology 1998;283(1):245-54.
1997: Torben Heick Jensen; A Jensen; Anne Marie Szilvay; Jørgen Kjems
Probing the structure of HIV-1 Rev by protein footprinting of multiple monoclonal antibody-binding sites.
FEBS letters 1997;414(1):50-4.
1996: Jens Lykke-Andersen; Roger A Garrett; Jørgen Kjems
Protein footprinting approach to mapping DNA binding sites of two archaeal homing enzymes: evidence for a two-domain protein structure.
Nucleic acids research 1996;24(20):3982-9.
1996: T O Tange; Torben Heick Jensen; Jørgen Kjems
In vitro interaction between human immunodeficiency virus type 1 Rev protein and splicing factor ASF/SF2-associated protein, p32.
The Journal of biological chemistry 1996;271(17):10066-72.
1995: H Dyhr-Mikkelsen; Jørgen Kjems
Inefficient spliceosome assembly and abnormal branch site selection in splicing of an HIV-1 transcript in vitro.
The Journal of biological chemistry 1995;270(41):24060-6.
1995: Torben Heick Jensen; A Jensen; Jørgen Kjems
Tools for the production and purification of full-length, N- or C-terminal 32P-labeled protein, applied to HIV-1 Gag and Rev.
Gene 1995;162(2):235-7.
1995: Torben Heick Jensen; H Leffers; Jørgen Kjems
Intermolecular binding sites of human immunodeficiency virus type 1 Rev protein determined by protein footprinting.
The Journal of biological chemistry 1995;270(23):13777-84.
1993: Jørgen Kjems; Phillip A Sharp
The basic domain of Rev from human immunodeficiency virus type 1 specifically blocks the entry of U4/U6.U5 small nuclear ribonucleoprotein in spliceosome assembly.
Journal of virology 1993;67(8):4769-76.
1991: Jørgen Kjems; Roger A Garrett
Ribosomal RNA introns in archaea and evidence for RNA conformational changes associated with splicing.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(2):439-43.
1991: Roger A Garrett; J Dalgaard; N Larsen; Jørgen Kjems; Alexander S Mankin
Archaeal rRNA operons.
Trends in biochemical sciences 1991;16(1):22-6.
1990: Jørgen Kjems; Roger A Garrett
Secondary structural elements exclusive to the sequences flanking ribosomal RNAs lend support to the monophyletic nature of the archaebacteria.
Journal of molecular evolution 1990;31(1):25-32.
1989: Jørgen Kjems; H Leffers; T Olesen; Roger A Garrett
A unique tRNA intron in the variable loop of the extreme thermophile Thermofilum pendens and its possible evolutionary implications.
The Journal of biological chemistry 1989;264(30):17834-7.
1989: Jørgen Kjems; J Jensen; T Olesen; Roger A Garrett
Comparison of transfer RNA and ribosomal RNA intron splicing in the extreme thermophile and archaebacterium Desulfurococcus mobilis.
Canadian journal of microbiology 1989;35(1):210-4.
1988: Jørgen Kjems; Roger A Garrett
Novel splicing mechanism for the ribosomal RNA intron in the archaebacterium Desulfurococcus mobilis.
Cell 1988;54(5):693-703.
1987: Jørgen Kjems; Roger A Garrett
Novel expression of the ribosomal RNA genes in the extreme thermophile and archaebacterium Desulfurococcus mobilis.
The EMBO journal 1987;6(11):3521-30.
1987: Jørgen Kjems; H Leffers; Roger A Garrett; G Wich; W Leinfelder; A Böck
Gene organization, transcription signals and processing of the single ribosomal RNA operon of the archaebacterium Thermoproteus tenax.
Nucleic acids research 1987;15(12):4821-35.
1987: H Leffers; Jørgen Kjems; L Ostergaard; N Larsen; Roger A Garrett
Evolutionary relationships amongst archaebacteria. A comparative study of 23 S ribosomal RNAs of a sulphur-dependent extreme thermophile, an extreme halophile and a thermophilic methanogen.
Journal of molecular biology 1987;195(1):43-61.
1985: Jørgen Kjems; S O Olesen; Roger A Garrett
Comparison of eubacterial and eukaryotic 5S RNA structures: a chemical modification study.
Biochemistry 1985;24(2):241-50.