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Curtis Klaassen

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Co-Publications
Name
59
Liu, Jie
34
Liu, Yaping
27
Cherrington, Nathan
24
Gregus, Zoltán
22
Slitt, Angela
21
Aleksunes, Lauren
20
Maher, Jonathan
16
Cheng, Xingguo
16
Tanaka, Yuji
14
Choudhuri, Supratim
13
Habeebu, Sultan
13
McKim, James
11
Chen, Chuan
10
Dieter, Matthew
9
Hartley, Dylan

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Publications

TOP 3
Cheng Xingguo; Klaassen Curtis D
Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys.
Yeager Ronnie L; Reisman Scott A; Aleksunes Lauren M; Klaassen Curtis D
Introducing the "TCDD-inducible AhR-Nrf2 gene battery".
Li Ye; Buckley David; Wang Shuang; Klaassen Curtis D; Zhong Xiao-bo
Genetic polymorphisms in the TATA box and upstream phenobarbital-responsive enhancer module of the UGT1A1 promoter have combined effects on UDP-glucuronosyltransferase 1A1 transcription mediated by constitutive androstane receptor, pregnane X receptor, or glucocorticoid receptor in human liver.

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All Publications

2009: Cheng Xingguo; Klaassen Curtis D
Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(11):2178-85.
2009: Yeager Ronnie L; Reisman Scott A; Aleksunes Lauren M; Klaassen Curtis D
Introducing the "TCDD-inducible AhR-Nrf2 gene battery".
Toxicological sciences : an official journal of the Society of Toxicology 2009;111(2):238-46.
2009: Li Ye; Buckley David; Wang Shuang; Klaassen Curtis D; Zhong Xiao-bo
Genetic polymorphisms in the TATA box and upstream phenobarbital-responsive enhancer module of the UGT1A1 promoter have combined effects on UDP-glucuronosyltransferase 1A1 transcription mediated by constitutive androstane receptor, pregnane X receptor, or glucocorticoid receptor in human liver.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(9):1978-86.
2009: Csanaky Iván L; Aleksunes Lauren M; Tanaka Yuji; Klaassen Curtis D
Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice.
American journal of physiology. Gastrointestinal and liver physiology 2009;297(3):G419-33.
2009: Cui Yue Julia; Yeager Ronnie L; Zhong Xiao-Bo; Klaassen Curtis D
Ontogenic expression of hepatic Ahr mRNA is associated with histone H3K4 di-methylation during mouse liver development.
Toxicology letters 2009;189(3):184-90.
2009: Klaassen Curtis D; Liu Jie; Diwan Bhalchandra A
Metallothionein protection of cadmium toxicity.
Toxicology and applied pharmacology 2009;238(3):215-20.
2009: Burnett Christina L; Bergfeld Wilma F; Belsito Donald V; Klaassen Curtis D; Marks James G; Shank Ronald C; Slaga Thomas J; Snyder Paul W; Andersen F Alan
Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl Thioglycolate, Isopropyl Thioglycolate, Magnesium Thioglycolate, Methyl Thioglycolate, Potassium Thioglycolate, Sodium Thioglycolate, and Thioglycolic Acid.
International journal of toxicology 2009;28(4 Suppl):68-133.
2009: Becker Lillian C; Bergfeld Wilma F; Belsito Donald V; Klaassen Curtis D; Marks James G; Shank Ronald C; Slaga Thomas J; Snyder Paul W; Andersen F Alan
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
International journal of toxicology 2009;28(4 Suppl):5-67.
2009: Aleksunes L M; Yeager R L; Klaassen C D
Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human livers.
Xenobiotica; the fate of foreign compounds in biological systems 2009;39(7):514-22.
2009: Beilke Lisa D; Aleksunes Lauren M; Olson Erik R; Besselsen David G; Klaassen Curtis D; Dvorak Katerina; Cherrington Nathan J
Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.
Toxicology letters 2009;188(1):38-44.
2009: Cui Yue J; Aleksunes Lauren M; Tanaka Yuji; Goedken Michael J; Klaassen Curtis D
Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice.
Toxicological sciences : an official journal of the Society of Toxicology 2009;110(1):47-60.
2009: Reisman Scott A; Csanaky Iván L; Aleksunes Lauren M; Klaassen Curtis D
Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice.
Toxicological sciences : an official journal of the Society of Toxicology 2009;109(1):31-40.
2009: Reisman Scott A; Csanaky Iván L; Yeager Ronnie L; Klaassen Curtis D
Nrf2 activation enhances biliary excretion of sulfobromophthalein by inducing glutathione-S-transferase activity.
Toxicological sciences : an official journal of the Society of Toxicology 2009;109(1):24-30.
2009: Beilke Lisa D; Aleksunes Lauren M; Holland Ricky D; Besselsen David G; Beger Rick D; Klaassen Curtis D; Cherrington Nathan J
Constitutive androstane receptor-mediated changes in bile acid composition contributes to hepatoprotection from lithocholic acid-induced liver injury in mice.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(5):1035-45.
2009: Li Ye; Cui Yue; Hart Steven N; Klaassen Curtis D; Zhong Xiao-bo
Dynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturation.
Molecular pharmacology 2009;75(5):1171-9.
2009: Yang Xiaoxia; Zhang Yu-Kun Jennifer; Esterly Noriko; Klaassen Curtis D; Wan Yu-Jui Yvonne
Gender disparity of hepatic lipid homoeostasis regulated by the circadian clock.
Journal of biochemistry 2009;145(5):609-23.
2009: Reisman Scott A; Buckley David B; Tanaka Yuji; Klaassen Curtis D
CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes.
Toxicology and applied pharmacology 2009;236(1):109-14.
2009: Reisman Scott A; Aleksunes Lauren M; Klaassen Curtis D
Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes.
Biochemical pharmacology 2009;77(7):1273-82.
2009: Lecureux Lloyd; Dieter Matthew Z; Nelson David M; Watson Linda; Wong Harvey; Gemzik Brian; Klaassen Curtis D; Lehman-McKeeman Lois D
Hepatobiliary disposition of thyroid hormone in Mrp2-deficient TR- rats: reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism.
Toxicological sciences : an official journal of the Society of Toxicology 2009;108(2):482-91.
2009: Tanaka Yuji; Aleksunes Lauren M; Cui Yue Julia; Klaassen Curtis D
ANIT-induced intrahepatic cholestasis alters hepatobiliary transporter expression via Nrf2-dependent and independent signaling.
Toxicological sciences : an official journal of the Society of Toxicology 2009;108(2):247-57.
2009: Buckley David B; Klaassen Curtis D
Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear factor erythroid 2-related factor 2.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(4):847-56.
2009: Buckley David B; Klaassen Curtis D
Mechanism of gender-divergent UDP-glucuronosyltransferase mRNA expression in mouse liver and kidney.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(4):834-40.
2009: Reisman Scott A; Yeager Ronnie L; Yamamoto Masayuki; Klaassen Curtis D
Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species.
Toxicological sciences : an official journal of the Society of Toxicology 2009;108(1):35-47.
2009: Gyamfi Maxwell Afari; Tanaka Yuji; He Lin; Klaassen Curtis D; Wan Yu-Jui Yvonne
Hepatic effects of a methionine-choline-deficient diet in hepatocyte RXRalpha-null mice.
Toxicology and applied pharmacology 2009;234(2):166-78.
2008: Maher Jonathan M; Aleksunes Lauren M; Dieter Matthew Z; Tanaka Yuji; Peters Jeffrey M; Manautou Jose E; Klaassen Curtis D
Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid.
Toxicological sciences : an official journal of the Society of Toxicology 2008;106(2):319-28.
2008: Knight Tamara R; Choudhuri Supratim; Klaassen Curtis D
Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers.
Toxicological sciences : an official journal of the Society of Toxicology 2008;106(2):329-38.
2008: Cheng Xingguo; Klaassen Curtis D
Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers.
Toxicological sciences : an official journal of the Society of Toxicology 2008;106(1):37-45.
2008: Cheng Xingguo; Klaassen Curtis D
Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors.
Toxicological sciences : an official journal of the Society of Toxicology 2008;106(1):29-36.
2008: Alnouti Yazen; Csanaky Iván L; Klaassen Curtis D
Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;873(2):209-17.
2008: Tanaka Yuji; Aleksunes Lauren M; Goedken Michael J; Chen Chuan; Reisman Scott A; Manautou José E; Klaassen Curtis D
Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity.
Toxicology and applied pharmacology 2008;231(3):364-73.
2008: Aleksunes Lauren M; Cui Yue; Klaassen Curtis D
Prominent expression of xenobiotic efflux transporters in mouse extraembryonic fetal membranes compared with placenta.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(9):1960-70.
2008: Merrell Matthew D; Jackson Jonathan P; Augustine Lisa M; Fisher Craig D; Slitt Angela L; Maher Jonathan M; Huang Wendong; Moore David D; Zhang Youcai; Klaassen Curtis D; Cherrington Nathan J
The Nrf2 activator oltipraz also activates the constitutive androstane receptor.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(8):1716-21.
2008: Plant Nick; Klaassen Curtis D
Editorial overview. Xenobiotic and endobiotic transporters: structure, function and regulation.
Xenobiotica; the fate of foreign compounds in biological systems 2008;38(7-8):654-5.
2008: Lickteig Andrew J; Cheng Xingguo; Augustine Lisa M; Klaassen Curtis D; Cherrington Nathan J
Tissue distribution, ontogeny and induction of the transporters Multidrug and toxin extrusion (MATE) 1 and MATE2 mRNA expression levels in mice.
Life sciences 2008;83(1-2):59-64.
2008: Lu Hong; Choudhuri Supratim; Ogura Kenichiro; Csanaky Iván L; Lei Xiaohong; Cheng Xingguo; Song Pei-zhen; Klaassen Curtis D
Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR.
Toxicological sciences : an official journal of the Society of Toxicology 2008;103(1):35-45.
2008: Tanaka Yuji; Aleksunes Lauren M; Yeager Ronnie L; Gyamfi Maxwell A; Esterly Noriko; Guo Grace L; Klaassen Curtis D
NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet.
The Journal of pharmacology and experimental therapeutics 2008;325(2):655-64.
2008: Alnouti Yazen; Klaassen Curtis D
Regulation of sulfotransferase enzymes by prototypical microsomal enzyme inducers in mice.
The Journal of pharmacology and experimental therapeutics 2008;324(2):612-21.
2008: Klaassen Curtis D; Lu Hong
Xenobiotic transporters: ascribing function from gene knockout and mutation studies.
Toxicological sciences : an official journal of the Society of Toxicology 2008;101(2):186-96.
2008: Alnouti Yazen; Klaassen Curtis D
Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice.
Toxicological sciences : an official journal of the Society of Toxicology 2008;101(1):51-64.
2008: Tanaka Yuji; Chen Chuan; Maher Jonathan M; Klaassen Curtis D
Ischemia-reperfusion of rat livers decreases liver and increases kidney multidrug resistance associated protein 2 (Mrp2).
Toxicological sciences : an official journal of the Society of Toxicology 2008;101(1):171-8.
2008: Aleksunes Lauren M; Slitt Angela L; Maher Jonathan M; Augustine Lisa M; Goedken Michael J; Chan Jefferson Y; Cherrington Nathan J; Klaassen Curtis D; Manautou José E
Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2.
Toxicology and applied pharmacology 2008;226(1):74-83.
2007: Cheng Xingguo; Buckley David; Klaassen Curtis D
Regulation of hepatic bile acid transporters Ntcp and Bsep expression.
Biochemical pharmacology 2007;74(11):1665-76.
2007: Knight Tamara Raphael; Choudhuri Supratim; Klaassen Curtis D
Constitutive mRNA expression of various glutathione S-transferase isoforms in different tissues of mice.
Toxicological sciences : an official journal of the Society of Toxicology 2007;100(2):513-24.
2007: Maher Jonathan M; Dieter Matthew Z; Aleksunes Lauren M; Slitt Angela L; Guo Grace; Tanaka Yuji; Scheffer George L; Chan Jefferson Y; Manautou Jose E; Chen Ying; Dalton Timothy P; Yamamoto Masayuki; Klaassen Curtis D
Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway.
Hepatology (Baltimore, Md.) 2007;46(5):1597-610.
2007: Petrick Jay S; Klaassen Curtis D
Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transport.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(10):1806-15.
2007: Fisher Craig D; Augustine Lisa M; Maher Jonathan M; Nelson David M; Slitt Angela L; Klaassen Curtis D; Lehman-McKeeman Lois D; Cherrington Nathan J
Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive androstane receptor and nuclear factor E2-related factor 2.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(6):995-1000.
2007: Pacyniak Erik K; Cheng Xingguo; Cunningham Michael L; Crofton Kevin; Klaassen Curtis D; Guo Grace L
The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators.
Toxicological sciences : an official journal of the Society of Toxicology 2007;97(1):94-102.
2007: Kim Dong-Won; Kim Ki-Young; Choi Byung-Sun; Youn Pilju; Ryu Doug-Young; Klaassen Curtis D; Park Jung-Duck
Regulation of metal transporters by dietary iron, and the relationship between body iron levels and cadmium uptake.
Archives of toxicology 2007;81(5):327-34.
2007: Chen Chuan; Cheng Xingguo; Dieter Matthew Z; Tanaka Yuji; Klaassen Curtis D
Activation of cAMP-dependent signaling pathway induces mouse organic anion transporting polypeptide 2 expression.
Molecular pharmacology 2007;71(4):1159-64.
2007: Tanaka Yuji; Maher Jonathan M; Chen Chuan; Klaassen Curtis D
Hepatic ischemia-reperfusion induces renal heme oxygenase-1 via NF-E2-related factor 2 in rats and mice.
Molecular pharmacology 2007;71(3):817-25.
2007: Slitt Angela L; Allen Katryn; Morrone Jennifer; Aleksunes Lauren M; Chen Chuan; Maher Jonathan M; Manautou José E; Cherrington Nathan J; Klaassen Curtis D
Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis.
Biochimica et biophysica acta 2007;1768(3):637-47.
2007: Nakamoto Kaori; Kidd Judith R; Jenison Robert D; Klaassen Curtis D; Wan Yu-Jui Yvonne; Kidd Kenneth K; Zhong Xiao-Bo
Genotyping and haplotyping of CYP2C19 functional alleles on thin-film biosensor chips.
Pharmacogenetics and genomics 2007;17(2):103-14.
2007: Moffit Jeffrey S; Aleksunes Lauren M; Kardas Michael J; Slitt Angela L; Klaassen Curtis D; Manautou José E
Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen.
Toxicology 2007;230(2-3):197-206.
2007: Alnouti Yazen M; Shelby Melinda K; Chen Chuan; Klaassen Curtis D
Influence of phenobarbital on morphine metabolism and disposition: LC-MS/MS determination of morphine (M) and morphine-3-glucuronide (M3G) in Wistar-Kyoto rat serum, bile, and urine.
Current drug metabolism 2007;8(1):79-89.
2007: Buckley David B; Klaassen Curtis D
Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(1):121-7.
2006: Cheng Xingguo; Klaassen Curtis D
Regulation of mRNA expression of xenobiotic transporters by the pregnane x receptor in mouse liver, kidney, and intestine.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(11):1863-7.
2006: Shelby M K; Klaassen C D
Induction of rat UDP-glucuronosyltransferases in liver and duodenum by microsomal enzyme inducers that activate various transcriptional pathways.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(10):1772-8.
2006: Cheng Xingguo; Maher Jonathan; Lu Hong; Klaassen Curtis D
Endocrine regulation of gender-divergent mouse organic anion-transporting polypeptide (Oatp) expression.
Molecular pharmacology 2006;70(4):1291-7.
2006: Alnouti Yazen; Klaassen Curtis D
Tissue distribution and ontogeny of sulfotransferase enzymes in mice.
Toxicological sciences : an official journal of the Society of Toxicology 2006;93(2):242-55.
2006: Maher J M; Slitt A L; Callaghan T N; Cheng X; Cheung C; Gonzalez F J; Klaassen C D
Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1alpha.
Biochemical pharmacology 2006;72(4):512-22.
2006: Tanaka Yuji; Chen Chuan; Maher Jonathan M; Klaassen Curtis D
Kupffer cell-mediated downregulation of hepatic transporter expression in rat hepatic ischemia-reperfusion.
Transplantation 2006;82(2):258-66.
2006: Choudhuri Supratim; Klaassen Curtis D
Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters.
International journal of toxicology 2006;25(4):231-59.
2006: Slitt A L; Cherrington N J; Fisher C D; Negishi M; Klaassen C D
Induction of genes for metabolism and transport by trans-stilbene oxide in livers of Sprague-Dawley and Wistar-Kyoto rats.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(7):1190-7.
2006: Maher J M; Cheng X; Tanaka Y; Scheffer G L; Klaassen C D
Hormonal regulation of renal multidrug resistance-associated proteins 3 and 4 (Mrp3 and Mrp4) in mice.
Biochemical pharmacology 2006;71(10):1470-8.
2006: Moffit Jeffrey S; Aleksunes Lauren M; Maher Jonathan M; Scheffer George L; Klaassen Curtis D; Manautou José E
Induction of hepatic transporters multidrug resistance-associated proteins (Mrp) 3 and 4 by clofibrate is regulated by peroxisome proliferator-activated receptor alpha.
The Journal of pharmacology and experimental therapeutics 2006;317(2):537-45.
2006: Slitt A L; Cherrington N J; Dieter M Z; Aleksunes L M; Scheffer G L; Huang W; Moore D D; Klaassen C D
trans-Stilbene oxide induces expression of genes involved in metabolism and transport in mouse liver via CAR and Nrf2 transcription factors.
Molecular pharmacology 2006;69(5):1554-63.
2006: Maher J M; Cherrington N J; Slitt A L; Klaassen C D
Tissue distribution and induction of the rat multidrug resistance-associated proteins 5 and 6.
Life sciences 2006;78(19):2219-25.
2006: Alnouti Yazen; Petrick Jay S; Klaassen Curtis D
Tissue distribution and ontogeny of organic cation transporters in mice.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(3):477-82.
2006: Leslie Elaine M; Liu Jie; Klaassen Curtis D; Waalkes Michael P
Acquired cadmium resistance in metallothionein-I/II(-/-) knockout cells: role of the T-type calcium channel Cacnalpha1G in cadmium uptake.
Molecular pharmacology 2006;69(2):629-39.
2006: Aleksunes Lauren M; Slitt Angela L; Maher Jonathan M; Dieter Matthew Z; Knight Tamara R; Goedken Michael; Cherrington Nathan J; Chan Jefferson Y; Klaassen Curtis D; Manautou José E
Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis.
Cell stress & chaperones 2006;11(4):356-63.
2006: Nakamoto Kaori; Wang Shuang; Jenison Robert D; Guo Grace L; Klaassen Curtis D; Wan Yu-Jui Yvonne; Zhong Xiao-bo
Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene.
BMC genetics 2006;7():29.
2005: Dai Guoli; Chou Nathan; He Lin; Gyamfi Maxwell A; Mendy Alphonse J; Slitt Angela L; Klaassen Curtis D; Wan Yu-Jui Y
Retinoid X receptor alpha Regulates the expression of glutathione s-transferase genes and modulates acetaminophen-glutathione conjugation in mouse liver.
Molecular pharmacology 2005;68(6):1590-6.
2005: Chen Chuan; Slitt Angela L; Dieter Mathew Z; Tanaka Yuji; Scheffer George L; Klaassen Curtis D
Up-regulation of Mrp4 expression in kidney of Mrp2-deficient TR- rats.
Biochemical pharmacology 2005;70(7):1088-95.
2005: Cheng Xingguo; Maher Jonathan; Dieter Matthew Z; Klaassen Curtis D
Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(9):1276-82.
2005: Klaassen C D; Slitt A L
Regulation of hepatic transporters by xenobiotic receptors.
Current drug metabolism 2005;6(4):309-28.
2005: Cheng Xingguo; Maher Jonathan; Chen Chuan; Klaassen Curtis D
Tissue distribution and ontogeny of mouse organic anion transporting polypeptides (Oatps).
Drug metabolism and disposition: the biological fate of chemicals 2005;33(7):1062-73.
2005: Maher Jonathan M; Cheng Xingguo; Slitt Angela L; Dieter Matthew Z; Klaassen Curtis D
Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(7):956-62.
2005: Maher Jonathan M; Slitt Angela L; Cherrington Nathan J; Cheng Xingguo; Klaassen Curtis D
Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(7):947-55.
2005: Tanaka Yuji; Slitt Angela L; Leazer Tyra M; Maher Jonathan M; Klaassen Curtis D
Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice.
Biochemical and biophysical research communications 2005;326(1):181-7.
2005: Aleksunes Lauren M; Slitt Angela M; Cherrington Nathan J; Thibodeau Michael S; Klaassen Curtis D; Manautou José E
Differential expression of mouse hepatic transporter genes in response to acetaminophen and carbon tetrachloride.
Toxicological sciences : an official journal of the Society of Toxicology 2005;83(1):44-52.
2005: Li Ning; Klaassen Curtis D
Lipopolysaccharide-induced down-regulation of organic anion transporting polypeptide 4 (Oatp4; Slc21a10) is independent of tumor necrosis factor-alpha, Interleukin-1beta, interleukin-6, or inducible nitric oxide synthase.
Toxicological sciences : an official journal of the Society of Toxicology 2005;83(1):197-203.
2004: Dieter Matthew Z; Maher Jonathan M; Cheng Xingguo; Klaassen Curtis D
Expression and regulation of the sterol half-transporter genes ABCG5 and ABCG8 in rats.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2004;139(4):209-18.
2004: Li Ning; Choudhuri Supratim; Cherrington Nathan J; Klaassen Curtis D
Down-regulation of mouse organic anion-transporting polypeptide 4 (Oatp4; Oatp1b2; Slc21a10) mRNA by lipopolysaccharide through the toll-like receptor 4 (TLR4).
Drug metabolism and disposition: the biological fate of chemicals 2004;32(11):1265-71.
2004: Li Ning; Klaassen Curtis D
Role of liver-enriched transcription factors in the down-regulation of organic anion transporting polypeptide 4 (oatp4; oatplb2; slc21a10) by lipopolysaccharide.
Molecular pharmacology 2004;66(3):694-701.
2004: Vansell Nichole R; Muppidi Jagan R; Habeebu Sultan M; Klaassen Curtis D
Promotion of thyroid tumors in rats by pregnenolone-16alpha-carbonitrile (PCN) and polychlorinated biphenyl (PCB).
Toxicological sciences : an official journal of the Society of Toxicology 2004;81(1):50-9.
2004: Ryu Doug-Young; Lee Sung-Ja; Park Duk Woong; Choi Byung-Sun; Klaassen Curtis D; Park Jung-Duck
Dietary iron regulates intestinal cadmium absorption through iron transporters in rats.
Toxicology letters 2004;152(1):19-25.
2004: Cherrington Nathan J; Slitt Angela L; Li Ning; Klaassen Curtis D
Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(7):734-41.
2004: Buist Susan C N; Klaassen Curtis D
Rat and mouse differences in gender-predominant expression of organic anion transporter (Oat1-3; Slc22a6-8) mRNA levels.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(6):620-5.
2004: Heijne Wilbert H M; Slitt Angela L; van Bladeren Peter J; Groten John P; Klaassen Curtis D; Stierum Rob H; van Ommen Ben
Bromobenzene-induced hepatotoxicity at the transcriptome level.
Toxicological sciences : an official journal of the Society of Toxicology 2004;79(2):411-22.
2004: Chen Chuan; Klaassen Curtis D
Rat multidrug resistance protein 4 (Mrp4, Abcc4): molecular cloning, organ distribution, postnatal renal expression, and chemical inducibility.
Biochemical and biophysical research communications 2004;317(1):46-53.
2004: Xie Yaxiong; Liu Jie; Liu Yaping; Klaassen Curtis D; Waalkes Michael P
Toxicokinetic and genomic analysis of chronic arsenic exposure in multidrug-resistance mdr1a/1b(-/-) double knockout mice.
Molecular and cellular biochemistry 2004;255(1-2):11-8.
2003: Grasseschi Robert M; Ramaswamy Rajanna B; Levine Deborah J; Klaassen Curtis D; Wesselius Lewis J
Cadmium accumulation and detoxification by alveolar macrophages of cigarette smokers.
Chest 2003;124(5):1924-8.
2003: Choudhuri Supratim; Cherrington Nathan J; Li Ning; Klaassen Curtis D
Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(11):1337-45.
2003: Cherrington Nathan J; Slitt Angela L; Maher Jonathan M; Zhang Xiao-Xue; Zhang Jun; Huang Wendong; Wan Yu-Jui Yvonne; Moore David D; Klaassen Curtis D
Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(11):1315-9.
2003: Slitt A L; Cherrington N J; Maher J M; Klaassen C D
Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(9):1176-86.
2003: Chen Chuan; Staudinger Jeff L; Klaassen Curtis D
Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(7):908-15.
2003: Buist Susan C N; Cherrington Nathan J; Klaassen Curtis D
Endocrine regulation of rat organic anion transporters.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(5):559-64.
2003: Hood Alan; Allen Marcia L; Liu YaPing; Liu Jie; Klaassen Curtis D
Induction of T(4) UDP-GT activity, serum thyroid stimulating hormone, and thyroid follicular cell proliferation in mice treated with microsomal enzyme inducers.
Toxicology and applied pharmacology 2003;188(1):6-13.
2003: Shelby M K; Cherrington N J; Vansell N R; Klaassen C D
Tissue mRNA expression of the rat UDP-glucuronosyltransferase gene family.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(3):326-33.
2003: Leazer Tyra M; Klaassen Curtis D
The presence of xenobiotic transporters in rat placenta.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(2):153-67.
2002: Leazer Tyra M; Liu Yaping; Klaassen Curtis D
Cadmium absorption and its relationship to divalent metal transporter-1 in the pregnant rat.
Toxicology and applied pharmacology 2002;185(1):18-24.
2002: Johnson David R; Guo Grace L; Klaassen Curtis D
Expression of rat Multidrug Resistance Protein 2 (Mrp2) in male and female rats during normal and pregnenolone-16alpha-carbonitrile (PCN)-induced postnatal ontogeny.
Toxicology 2002;178(3):209-19.
2002: Park Jung D; Cherrington Nathan J; Klaassen Curtis D
Intestinal absorption of cadmium is associated with divalent metal transporter 1 in rats.
Toxicological sciences : an official journal of the Society of Toxicology 2002;68(2):288-94.
2002: Brady James M; Cherrington Nathan J; Hartley Dylan P; Buist Susan C; Li Ning; Klaassen Curtis D
Tissue distribution and chemical induction of multiple drug resistance genes in rats.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(7):838-44.
2002: Harstad Eric B; Klaassen Curtis D
iNOS-null mice are not resistant to cadmium chloride-induced hepatotoxicity.
Toxicology 2002;175(1-3):83-90.
2002: Harstad Eric B; Klaassen Curtis D
Analysis of strain difference in sensitivity to cadmium-induced hepatotoxicity in Fischer 344 and Sprague-Dawley rats.
Toxicological sciences : an official journal of the Society of Toxicology 2002;67(2):329-40.
2002: Johnson David R; Klaassen Curtis D
Regulation of rat multidrug resistance protein 2 by classes of prototypical microsomal enzyme inducers that activate distinct transcription pathways.
Toxicological sciences : an official journal of the Society of Toxicology 2002;67(2):182-9.
2002: Harstad Eric B; Klaassen Curtis D
Gadolinium chloride pretreatment prevents cadmium chloride-induced liver damage in both wild-type and MT-null mice.
Toxicology and applied pharmacology 2002;180(3):178-85.
2002: Li Ning; Hartley Dylan P; Cherrington Nathan J; Klaassen Curtis D
Tissue expression, ontogeny, and inducibility of rat organic anion transporting polypeptide 4.
The Journal of pharmacology and experimental therapeutics 2002;301(2):551-60.
2002: Choudhuri Supratim; Ogura Kenichiro; Klaassen Curtis D
Determination of transcription start site and analysis of promoter sequence, splice junction sites, intron sequence and codon usage bias of rat liver-specific organic anion transporter-1 (rlst-1/Oatp-4/Slc21a10) gene.
DNA sequence : the journal of DNA sequencing and mapping 2002;13(2):103-7.
2002: Johnson David R; Klaassen Curtis D
Role of rat multidrug resistance protein 2 in plasma and biliary disposition of dibromosulfophthalein after microsomal enzyme induction.
Toxicology and applied pharmacology 2002;180(1):56-63.
2002: Buist Susan C N; Cherrington Nathan J; Choudhuri Supratim; Hartley Dylan P; Klaassen Curtis D
Gender-specific and developmental influences on the expression of rat organic anion transporters.
The Journal of pharmacology and experimental therapeutics 2002;301(1):145-51.
2002: Guo Grace L; Staudinger Jeff; Ogura Kenichiro; Klaassen Curtis D
Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha-carbonitrile is via interaction with pregnane X receptor.
Molecular pharmacology 2002;61(4):832-9.
2002: Liu Jie; Kadiiska Maria B; Corton J Christopher; Qu Wei; Waalkes Michael P; Mason Ronald P; Liu Yaping; Klaassen Curtis D
Acute cadmium exposure induces stress-related gene expression in wild-type and metallothionein-I/II-null mice.
Free radical biology & medicine 2002;32(6):525-35.
2002: Harstad Eric B; Klaassen Curtis D
Tumor necrosis factor-alpha-null mice are not resistant to cadmium chloride-induced hepatotoxicity.
Toxicology and applied pharmacology 2002;179(3):155-62.
2002: Johnson David R; Habeebu Sultan S M; Klaassen Curtis D
Increase in bile flow and biliary excretion of glutathione-derived sulfhydryls in rats by drug-metabolizing enzyme inducers is mediated by multidrug resistance protein 2.
Toxicological sciences : an official journal of the Society of Toxicology 2002;66(1):16-26.
2002: Guo Grace L; Johnson David R; Klaassen Curtis D
Postnatal expression and induction by pregnenolone-16alpha-carbonitrile of the organic anion-transporting polypeptide 2 in rat liver.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(3):283-8.
2002: Vansell Nichole R; Klaassen Curtis D
Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(3):240-6.
2002: Park Jung D; Habeebu Sultan S M; Klaassen Curtis D
Testicular toxicity of di-(2-ethylhexyl)phthalate in young Sprague-Dawley rats.
Toxicology 2002;171(2-3):105-15.
2002: Vansell Nichole R; Klaassen Curtis D
Effect of microsomal enzyme inducers on the biliary excretion of triiodothyronine (T(3)) and its metabolites.
Toxicological sciences : an official journal of the Society of Toxicology 2002;65(2):184-91.
2002: Slitt A L; Cherrington N J; Hartley D P; Leazer T M; Klaassen C D
Tissue distribution and renal developmental changes in rat organic cation transporter mRNA levels.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(2):212-9.
2002: Klaassen Curtis D
Xenobiotic transporters: another protective mechanism for chemicals.
International journal of toxicology 2002;21(1):7-12.
2002: Guo Grace L; Choudhuri Supratim; Klaassen Curtis D
Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways.
The Journal of pharmacology and experimental therapeutics 2002;300(1):206-12.
2002: Cherrington Nathan J; Hartley Dylan P; Li Ning; Johnson David R; Klaassen Curtis D
Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats.
The Journal of pharmacology and experimental therapeutics 2002;300(1):97-104.
2002: Liu Jie; Liu Yaping; Powell Douglas A; Waalkes Michael P; Klaassen Curtis D
Multidrug-resistance mdr1a/1b double knockout mice are more sensitive than wild type mice to acute arsenic toxicity, with higher arsenic accumulation in tissues.
Toxicology 2002;170(1-2):55-62.
2001: Habeebu S S; Liu Y; Park J D; Klaassen C D
Strain differences in the toxicity of cadmium to trigeminal ganglia in mice.
Toxicology and applied pharmacology 2001;177(3):200-7.
2001: Vansell N R; Klaassen C D
Increased biliary excretion of thyroxine by microsomal enzyme inducers.
Toxicology and applied pharmacology 2001;176(3):187-94.
2001: Guo G L; Klaassen C D
Protein kinase C suppresses rat organic anion transporting polypeptide 1- and 2-mediated uptake.
The Journal of pharmacology and experimental therapeutics 2001;299(2):551-7.
2001: Staudinger J; Liu Y; Madan A; Habeebu S; Klaassen C D
Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(11):1467-72.
2001: Liu J; Corton C; Dix D J; Liu Y; Waalkes M P; Klaassen C D
Genetic background but not metallothionein phenotype dictates sensitivity to cadmium-induced testicular injury in mice.
Toxicology and applied pharmacology 2001;176(1):1-9.
2001: Liu Y; Liu J; Klaassen C D
Metallothionein-null and wild-type mice show similar cadmium absorption and tissue distribution following oral cadmium administration.
Toxicology and applied pharmacology 2001;175(3):253-9.
2001: Takiguchi M; Cherrington N J; Hartley D P; Klaassen C D; Waalkes M P
Cyproterone acetate induces a cellular tolerance to cadmium in rat liver epithelial cells involving reduced cadmium accumulation.
Toxicology 2001;165(1):13-25.
2001: Park J D; Liu Y; Klaassen C D
Protective effect of metallothionein against the toxicity of cadmium and other metals(1).
Toxicology 2001;163(2-3):93-100.
2001: Rausch-Derra L C; Hartley D P; Meier P J; Klaassen C D
Differential effects of microsomal enzyme-inducing chemicals on the hepatic expression of rat organic anion transporters, OATP1 and OATP2.
Hepatology (Baltimore, Md.) 2001;33(6):1469-78.
2001: Staudinger J L; Goodwin B; Jones S A; Hawkins-Brown D; MacKenzie K I; LaTour A; Liu Y; Klaassen C D; Brown K K; Reinhard J; Willson T M; Koller B H; Kliewer S A
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3369-74.
2001: Ogura K; Choudhuri S; Klaassen C D
Genomic organization and tissue-specific expression of splice variants of mouse organic anion transporting polypeptide 2.
Biochemical and biophysical research communications 2001;281(2):431-9.
2001: Choudhuri S; Ogura K; Klaassen C D
Cloning, expression, and ontogeny of mouse organic anion-transporting polypeptide-5, a kidney-specific organic anion transporter.
Biochemical and biophysical research communications 2001;280(1):92-8.
2000: Liu Y; Liu J; Habeebu S M; Waalkes M P; Klaassen C D
Metallothionein-I/II null mice are sensitive to chronic oral cadmium-induced nephrotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2000;57(1):167-76.
2000: Jeong S H; Habeebu S S; Klaassen C D
Cadmium decreases gap junctional intercellular communication in mouse liver.
Toxicological sciences : an official journal of the Society of Toxicology 2000;57(1):156-66.
2000: Liu J; Sendelbach L E; Parkinson A; Klaassen C D
Endotoxin pretreatment protects against the hepatotoxicity of acetaminophen and carbon tetrachloride: role of cytochrome P450 suppression.
Toxicology 2000;147(3):167-76.
2000: Liu J; Liu Y; Habeebu S M; Waalkes M P; Klaassen C D
Chronic combined exposure to cadmium and arsenic exacerbates nephrotoxicity, particularly in metallothionein-I/II null mice.
Toxicology 2000;147(3):157-66.
2000: Choudhuri S; Ogura K; Klaassen C D
Cloning of the full-length coding sequence of rat liver-specific organic anion transporter-1 (rlst-1) and a splice variant and partial characterization of the rat lst-1 gene.
Biochemical and biophysical research communications 2000;274(1):79-86.
2000: Habeebu S S; Liu J; Liu Y; Klaassen C D
Metallothionein-null mice are more susceptible than wild-type mice to chronic CdCl(2)-induced bone injury.
Toxicological sciences : an official journal of the Society of Toxicology 2000;56(1):211-9.
2000: Ogura K; Choudhuri S; Klaassen C D
Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (lst-1).
Biochemical and biophysical research communications 2000;272(2):563-70.
2000: Habeebu S S; Liu J; Liu Y; Klaassen C D
Metallothionein-null mice are more sensitive than wild-type mice to liver injury induced by repeated exposure to cadmium.
Toxicological sciences : an official journal of the Society of Toxicology 2000;55(1):223-32.
2000: Hood A; Klaassen C D
Differential effects of microsomal enzyme inducers on in vitro thyroxine (T(4)) and triiodothyronine (T(3)) glucuronidation.
Toxicological sciences : an official journal of the Society of Toxicology 2000;55(1):78-84.
2000: Hartley D P; Klaassen C D
Detection of chemical-induced differential expression of rat hepatic cytochrome P450 mRNA transcripts using branched DNA signal amplification technology.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(5):608-16.
2000: Dunn R T; Klaassen C D
Thyroid hormone modulation of rat sulphotransferase mRNA expression.
Xenobiotica; the fate of foreign compounds in biological systems 2000;30(4):345-57.
2000: Boles J W; Klaassen C D
Effects of molybdate and pentachlorophenol on the sulfation of acetaminophen.
Toxicology 2000;146(1):23-35.
2000: Kolaja K L; Engelken D T; Klaassen C D
Inhibition of gap-junctional-intercellular communication in intact rat liver by nongenotoxic hepatocarcinogens.
Toxicology 2000;146(1):15-22.
2000: Hood A; Klaassen C D
Effects of microsomal enzyme inducers on outer-ring deiodinase activity toward thyroid hormones in various rat tissues.
Toxicology and applied pharmacology 2000;163(3):240-8.
2000: Kolaja K L; Petrick J S; Klaassen C D
Inhibition of gap-junctional-intercellular communication in thyroid-follicular cells by propylthiouracil and low iodine diet.
Toxicology 2000;143(2):195-202.
1999: Hood A; Hashmi R; Klaassen C D
Effects of microsomal enzyme inducers on thyroid-follicular cell proliferation, hyperplasia, and hypertrophy.
Toxicology and applied pharmacology 1999;160(2):163-70.
1999: Rojas P; Klaassen C D
Metallothionein-I and -II knock-out mice are not more sensitive than control mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity.
Neuroscience letters 1999;273(2):113-6.
1999: Liu J; Liu Y; Habeebu S S; Klaassen C D
Metallothionein-null mice are highly susceptible to the hematotoxic and immunotoxic effects of chronic CdCl2 exposure.
Toxicology and applied pharmacology 1999;159(2):98-108.
1999: Liu Y; Liu J; Habeebu S S; Klaassen C D
Metallothionein protects against the nephrotoxicity produced by chronic CdMT exposure.
Toxicological sciences : an official journal of the Society of Toxicology 1999;50(2):221-7.
1999: Hood A; Liu J; Klaassen C D
Effects of phenobarbital, pregnenolone-16alpha-carbonitrile, and propylthiouracil on thyroid follicular cell proliferation.
Toxicological sciences : an official journal of the Society of Toxicology 1999;50(1):45-53.
1999: Dunn R T; Gleason B A; Hartley D P; Klaassen C D
Postnatal ontogeny and hormonal regulation of sulfotransferase SULT1B1 in male and female rats.
The Journal of pharmacology and experimental therapeutics 1999;290(1):319-24.
1999: Dunn R T; Kolaja K L; Klaassen C D
Effect of partial hepatectomy on the expression of seven rat sulphotransferase mRNAs.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(6):583-93.
1999: Hood A; Liu Y P; Gattone V H; Klaassen C D
Sensitivity of thyroid gland growth to thyroid stimulating hormone (TSH) in rats treated with antithyroid drugs.
Toxicological sciences : an official journal of the Society of Toxicology 1999;49(2):263-71.
1999: Kolaja K L; Hood A M; Klaassen C D
The UDP-glucuronyltransferase inducers, phenobarbital and pregnenolone-16alpha-carbonitrile, enhance thyroid-follicular cell apoptosis: association with TGF-beta1 expression.
Toxicology letters 1999;106(2-3):143-50.
1999: Boles J W; Klaassen C D
Effects of molybdate and pentachlorophenol on the sulfation of alpha-naphthol.
Toxicology letters 1999;106(1):1-8.
1999: Liu J; Liu Y; Hartley D; Klaassen C D; Shehin-Johnson S E; Lucas A; Cohen S D
Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity.
The Journal of pharmacology and experimental therapeutics 1999;289(1):580-6.
1999: Liu J; Kimler B F; Liu Y; Klaassen C D
Metallothionein-I transgenic mice are not protected from gamma-radiation.
Toxicology letters 1999;104(3):183-7.
1999: Klaassen C D; Liu J; Choudhuri S
Metallothionein: an intracellular protein to protect against cadmium toxicity.
Annual review of pharmacology and toxicology 1999;39():267-94.
1998: Liu J; Liu Y; Habeebu S S; Klaassen C D
Susceptibility of MT-null mice to chronic CdCl2-induced nephrotoxicity indicates that renal injury is not mediated by the CdMT complex.
Toxicological sciences : an official journal of the Society of Toxicology 1998;46(1):197-203.
1998: Kolaja K L; Klaassen C D
Dose-response examination of UDP-glucuronosyltransferase inducers and their ability to increase both TGF-beta expression and thyroid follicular cell apoptosis.
Toxicological sciences : an official journal of the Society of Toxicology 1998;46(1):31-7.
1998: Liu J; Habeebu S S; Liu Y; Klaassen C D
Acute CdMT injection is not a good model to study chronic Cd nephropathy: comparison of chronic CdCl2 and CdMT exposure with acute CdMT injection in rats.
Toxicology and applied pharmacology 1998;153(1):48-58.
1998: Klaassen C D; Liu J
Metallothionein transgenic and knock-out mouse models in the study of cadmium toxicity.
The Journal of toxicological sciences 1998;23 Suppl 2():97-102.
1998: Boles J W; Klaassen C D
Effects of molybdate and pentachlorophenol on the sulfation of dehydroepiandrosterone.
Toxicology and applied pharmacology 1998;151(1):105-9.
1998: Dunn R T; Klaassen C D
Tissue-specific expression of rat sulfotransferase messenger RNAs.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(6):598-604.
1998: Boles J W; Klaassen C D
Effects of molybdate on the sulfation of harmol and alpha-naphthol.
Toxicology 1998;127(1-3):121-7.
1998: Habeebu S S; Liu J; Klaassen C D
Cadmium-induced apoptosis in mouse liver.
Toxicology and applied pharmacology 1998;149(2):203-9.
1998: Liu J; Liu Y; Habeebu S S; Klaassen C D
Metallothionein (MT)-null mice are sensitive to cisplatin-induced hepatotoxicity.
Toxicology and applied pharmacology 1998;149(1):24-31.
1998: Klaassen C D; Liu L; Dunn R T
Regulation of sulfotransferase mRNA expression in male and female rats of various ages.
Chemico-biological interactions 1998;109(1-3):299-313.
1998: Klaassen C D; Liu J
Induction of metallothionein as an adaptive mechanism affecting the magnitude and progression of toxicological injury.
Environmental health perspectives 1998;106 Suppl 1():297-300.
1997: Klaassen C D; Boles J W
Sulfation and sulfotransferases 5: the importance of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) in the regulation of sulfation.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997;11(6):404-18.
1997: Klaassen C D; Liu J
Role of metallothionein in cadmium-induced hepatotoxicity and nephrotoxicity.
Drug metabolism reviews 1997;29(1-2):79-102.
1996: Gregus Z; Fekete T; Halászi E; Klaassen C D
Does hepatic ATP depletion impair glycine conjugation in vivo?
Drug metabolism and disposition: the biological fate of chemicals 1996;24(12):1347-54.
1996: Liu L; LeCluyse E L; Liu J; Klaassen C D
Sulfotransferase gene expression in primary cultures of rat hepatocytes.
Biochemical pharmacology 1996;52(10):1621-30.
1996: Kramer K K; Zoelle J T; Klaassen C D
Induction of metallothionein mRNA and protein in primary murine neuron cultures.
Toxicology and applied pharmacology 1996;141(1):1-7.
1996: Zheng H; Liu J; Liu Y; Klaassen C D
Hepatocytes from metallothionein-I and II knock-out mice are sensitive to cadmium- and tert-butylhydroperoxide-induced cytotoxicity.
Toxicology letters 1996;87(2-3):139-45.
1996: Liu L; Klaassen C D
Ontogeny and hormonal basis of female-dominant rat hepatic sulfotransferases.
The Journal of pharmacology and experimental therapeutics 1996;279(1):386-91.
1996: Liu L; Klaassen C D
Ontogeny and hormonal basis of male-dominant rat hepatic sulfotransferases.
Molecular pharmacology 1996;50(3):565-72.
1996: Liu L; Klaassen C D
Regulation of hepatic sulfotransferases by steroidal chemicals in rats.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(8):854-8.
1996: Liu L; Klaassen C D
Different mechanism of saturation of acetaminophen sulfate conjugation in mice and rats.
Toxicology and applied pharmacology 1996;139(1):128-34.
1996: Gregus Z; Fekete T; Halászi E; Klaassen C D
Lipoic acid impairs glycine conjugation of benzoic acid and renal excretion of benzoylglycine.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(6):682-8.
1996: Liu Y P; Liu J; Palmiter R D; Klaassen C D
Metallothionein-I-transgenic mice are not protected from acute cadmium-metallothionein-induced nephrotoxicity.
Toxicology and applied pharmacology 1996;137(2):307-15.
1996: Liu J; Liu Y; Michalska A E; Choo K H; Klaassen C D
Metallothionein plays less of a protective role in cadmium-metallothionein-induced nephrotoxicity than in cadmium chloride-induced hepatotoxicity.
The Journal of pharmacology and experimental therapeutics 1996;276(3):1216-23.
1996: Choudhuri S; Liu W L; Berman N E; Klaassen C D
Cadmium accumulation and metallothionein expression in brain of mice at different stages of development.
Toxicology letters 1996;84(3):127-33.
1996: Liu J; Klaassen C D
Absorption and distribution of cadmium in metallothionein-I transgenic mice.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1996;29(2):294-300.
1996: Oguro T; Madhu C; Liu J; Klaassen C D
Molybdate impairs glycosaminoglycan sulfation in rat cartilage.
Toxicology and applied pharmacology 1996;136(2):354-60.
1996: Liu J; Liu Y; Michalska A E; Choo K H; Klaassen C D
Distribution and retention of cadmium in metallothionein I and II null mice.
Toxicology and applied pharmacology 1996;136(2):260-8.
1996: Zheng H; Liu J; Choo K H; Michalska A E; Klaassen C D
Metallothionein-I and -II knock-out mice are sensitive to cadmium-induced liver mRNA expression of c-jun and p53.
Toxicology and applied pharmacology 1996;136(2):229-35.
1996: Kramer K K; Liu J; Choudhuri S; Klaassen C D
Induction of metallothionein mRNA and protein in murine astrocyte cultures.
Toxicology and applied pharmacology 1996;136(1):94-100.
1995: Thompson T N; Klaassen C D
The effects of hepatic microsomal enzyme inducers on the pharmacokinetics of ouabain after portal and systemic administration to rats.
The Journal of pharmacy and pharmacology 1995;47(12A):1041-7.
1995: Madhu C; Gregus Z; Klaassen C D
Simple method for analysis of diquat in biological fluids and tissues by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical applications 1995;674(2):193-6.
1995: Iszard M B; Liu J; Klaassen C D
Effect of several metallothionein inducers on oxidative stress defense mechanisms in rats.
Toxicology 1995;104(1-3):25-33.
1995: Liu Y; Liu J; Iszard M B; Andrews G K; Palmiter R D; Klaassen C D
Transgenic mice that overexpress metallothionein-I are protected from cadmium lethality and hepatotoxicity.
Toxicology and applied pharmacology 1995;135(2):222-8.
1995: Kim H J; Rozman P; Klaassen C D
Acetaminophen does not decrease hepatic 3'-phosphoadenosine 5'-phosphosulfate in mice.
The Journal of pharmacology and experimental therapeutics 1995;275(3):1506-11.
1995: Liu J; Liu Y; Parkinson A; Klaassen C D
Effect of oleanolic acid on hepatic toxicant-activating and detoxifying systems in mice.
The Journal of pharmacology and experimental therapeutics 1995;275(2):768-74.
1995: Kim H J; Cho J H; Klaassen C D
Depletion of hepatic 3'-phosphoadenosine 5'-phosphosulfate (PAPS) and sulfate in rats by xenobiotics that are sulfated.
The Journal of pharmacology and experimental therapeutics 1995;275(2):654-8.
1995: Liu J; Liu Y; Bullock P; Klaassen C D
Suppression of liver cytochrome P450 by alpha-hederin: relevance to hepatoprotection.
Toxicology and applied pharmacology 1995;134(1):124-31.
1995: Iszard M B; Liu J; Liu Y; Dalton T; Andrews G K; Palmiter R D; Klaassen C D
Characterization of metallothionein-I-transgenic mice.
Toxicology and applied pharmacology 1995;133(2):305-12.
1995: Kim H J; Madhu C; Cho J H; Klaassen C D
In vivo modification of 3'-phosphoadenosine 5'-phosphosulfate and sulfate by infusion of sodium sulfate, cysteine, and methionine.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(8):840-5.
1995: Zheng H; Berman N E; Klaassen C D
Chemical modulation of metallothionein I and III mRNA in mouse brain.
Neurochemistry international 1995;27(1):43-58.
1995: Dorian C; Klaassen C D
Protection by zinc-metallothionein (ZnMT) against cadmium-metallothionein-induced nephrotoxicity.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1995;26(1):99-106.
1995: Liu J; Liu Y; Barter R A; Klaassen C D
Alteration of thyroid homeostasis by UDP-glucuronosyltransferase inducers in rats: a dose-response study.
The Journal of pharmacology and experimental therapeutics 1995;273(2):977-85.
1995: Choudhuri S; Kramer K K; Berman N E; Dalton T P; Andrews G K; Klaassen C D
Constitutive expression of metallothionein genes in mouse brain.
Toxicology and applied pharmacology 1995;131(1):144-54.
1995: Liu J; Liu Y; Klaassen C D
Protective effect of oleanolic acid against chemical-induced acute necrotic liver injury in mice.
Zhongguo yao li xue bao = Acta pharmacologica Sinica 1995;16(2):97-102.
1995: Dorian C; Gattone V H; Klaassen C D
Discrepancy between the nephrotoxic potencies of cadmium-metallothionein and cadmium chloride and the renal concentration of cadmium in the proximal convoluted tubules.
Toxicology and applied pharmacology 1995;130(1):161-8.
1994: Henry R B; Liu J; Choudhuri S; Klaassen C D
Species variation in hepatic metallothionein.
Toxicology letters 1994;74(1):23-33.
1994: Liu J; Liu Y; Klaassen C D
Nephrotoxicity of CdCl2 and Cd-metallothionein in cultured rat kidney proximal tubules and LLC-PK1 cells.
Toxicology and applied pharmacology 1994;128(2):264-70.
1994: Barter R A; Klaassen C D
Reduction of thyroid hormone levels and alteration of thyroid function by four representative UDP-glucuronosyltransferase inducers in rats.
Toxicology and applied pharmacology 1994;128(1):9-17.
1994: Oguro T; Gregus Z; Madhu C; Liu L; Klaassen C D
Molybdate depletes hepatic 3-phosphoadenosine 5-phosphosulfate and impairs the sulfation of acetaminophen in rats.
The Journal of pharmacology and experimental therapeutics 1994;270(3):1145-51.
1994: Klaassen C D; Choudhuri S; McKim J M; Lehman-McKeeman L D; Kershaw W C
In vitro and in vivo studies on the degradation of metallothionein.
Environmental health perspectives 1994;102 Suppl 3():141-6.
1994: Gregus Z; Kim H J; Madhu C; Liu Y; Rozman P; Klaassen C D
Sulfation of acetaminophen and acetaminophen-induced alterations in sulfate and 3'-phosphoadenosine 5'-phosphosulfate homeostasis in rats with deficient dietary intake of sulfur.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(5):725-30.
1994: Kreppel H; Liu J; Liu Y; Reichl F X; Klaassen C D
Zinc-induced arsenite tolerance in mice.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1994;23(1):32-7.
1994: Gregus Z; Oguro T; Klaassen C D
Nutritionally and chemically induced impairment of sulfate activation and sulfation of xenobiotics in vivo.
Chemico-biological interactions 1994;92(1-3):169-77.
1994: Liu J; Liu Y; Klaassen C D
The effect of Chinese hepatoprotective medicines on experimental liver injury in mice.
Journal of ethnopharmacology 1994;42(3):183-91.
1994: Choudhuri S; McKim J M; Klaassen C D
Induction of metallothionein by superantigenic bacterial exotoxin: probable involvement of the immune system.
Biochimica et biophysica acta 1994;1225(2):171-9.
1994: Liu J; Liu Y; Mao Q; Klaassen C D
The effects of 10 triterpenoid compounds on experimental liver injury in mice.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1994;22(1):34-40.
1993: Gregus Z; Fekete T; Varga F; Klaassen C D
Effect of valproic acid on glycine conjugation of benzoic acid.
The Journal of pharmacology and experimental therapeutics 1993;267(3):1068-75.
1993: Liu J; Liu Y; Madhu C; Klaassen C D
Protective effects of oleanolic acid on acetaminophen-induced hepatotoxicity in mice.
The Journal of pharmacology and experimental therapeutics 1993;266(3):1607-13.
1993: Bauman J W; Liu J; Klaassen C D
Production of metallothionein and heat-shock proteins in response to metals.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1993;21(1):15-22.
1993: Liu J; Choudhuri S; Liu Y; Kreppel H; Andrews G K; Klaassen C D
Induction of metallothionein by alpha-hederin.
Toxicology and applied pharmacology 1993;121(1):144-51.
1993: Liu Y; Kreppel H; Liu J; Choudhuri S; Klaassen C D
Oleanolic acid protects against cadmium hepatotoxicity by inducing metallothionein.
The Journal of pharmacology and experimental therapeutics 1993;266(1):400-6.
1993: Choudhuri S; McKim J M; Klaassen C D
Differential expression of the metallothionein gene in liver and brain of mice and rats.
Toxicology and applied pharmacology 1993;119(1):1-10.
1993: Madhu C; Mitchell D Y; Klaassen C D
Effect of P-450 inducers on biliary excretion of glutathione and its hydrolysis products. Correlation between hepatic gamma-glutamyltranspeptidase activity and the proportion of glutathione hydrolysis products in bile.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(2):342-9.
1993: Gregus Z; Fekete T; Varga F; Klaassen C D
Dependence of glycine conjugation on availability of glycine: role of the glycine cleavage system.
Xenobiotica; the fate of foreign compounds in biological systems 1993;23(2):141-53.
1993: McKim J M; McKim J M; Naumann S; Hammermeister D E; Hoffman A D; Klaassen C D
In vivo microdialysis sampling of phenol and phenyl glucuronide in the blood of unanesthetized rainbow trout: implications for toxicokinetic studies.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1993;20(2):190-8.
1993: Kreppel H; Bauman J W; Liu J; McKim J M; Klaassen C D
Induction of metallothionein by arsenicals in mice.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1993;20(2):184-9.
1992: Dorian C; Gattone V H; Klaassen C D
Accumulation and degradation of the protein moiety of cadmium-metallothionein (CdMT) in the mouse kidney.
Toxicology and applied pharmacology 1992;117(2):242-8.
1992: Bauman J W; Madhu C; McKim J M; Liu Y; Klaassen C D
Induction of hepatic metallothionein by paraquat.
Toxicology and applied pharmacology 1992;117(2):233-41.
1992: Bauman J W; Liu Y P; Andrews G K; Klaassen C D
Examination of potential mechanism(s) of metallothionein induction by diethyl maleate.
Toxicology and applied pharmacology 1992;117(2):226-32.
1992: Madhu C; Gregus Z; Klaassen C D
Marked interanimal differences in susceptibility of Sprague-Dawley rats to diquat-induced oxidative stress in the liver: correlation with hepatic uptake of diquat.
The Journal of pharmacology and experimental therapeutics 1992;263(3):1003-8.
1992: Liu J; Kershaw W C; Liu Y P; Klaassen C D
Cadmium-induced hepatic endothelial cell injury in inbred strains of mice.
Toxicology 1992;75(1):51-62.
1992: McKim J M; Choudhuri S; Klaassen C D
In vitro degradation of apo-, zinc-, and cadmium-metallothionein by cathepsins B, C, and D.
Toxicology and applied pharmacology 1992;116(1):117-24.
1992: Madhu C; Gregus Z; Cheng C C; Klaassen C D
Identification of the mixed disulfide of glutathione and cysteinylglycine in bile: dependence on gamma-glutamyl transferase and responsiveness to oxidative stress.
The Journal of pharmacology and experimental therapeutics 1992;262(3):896-900.
1992: Barter R A; Klaassen C D
Rat liver microsomal UDP-glucuronosyltransferase activity toward thyroxine: characterization, induction, and form specificity.
Toxicology and applied pharmacology 1992;115(2):261-7.
1992: Madhu C; Maziasz T; Klaassen C D
Effect of pregnenolone-16 alpha-carbonitrile and dexamethasone on acetaminophen-induced hepatotoxicity in mice.
Toxicology and applied pharmacology 1992;115(2):191-8.
1992: Goon D; Klaassen C D
Effects of microsomal enzyme inducers upon UDP-glucuronic acid concentration and UDP-glucuronosyltransferase activity in the rat intestine and liver.
Toxicology and applied pharmacology 1992;115(2):253-60.
1992: Choudhuri S; McKim J M; Klaassen C D
Role of hepatic lysosomes in the degradation of metallothionein.
Toxicology and applied pharmacology 1992;115(1):64-71.
1992: Bauman J W; McKim J M; Liu J; Klaassen C D
Induction of metallothionein by diethyl maleate.
Toxicology and applied pharmacology 1992;114(2):188-96.
1992: Kim H J; Rozman P; Madhu C; Klaassen C D
Homeostasis of sulfate and 3'-phosphoadenosine 5'-phosphosulfate in rats after acetaminophen administration.
The Journal of pharmacology and experimental therapeutics 1992;261(3):1015-21.
1992: Liu J; McKim J M; Liu Y P; Klaassen C D
Effects of butyrate homologues on metallothionein induction in rat primary hepatocyte cultures.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1992;28A(5):320-6.
1992: Gregus Z; Stein A F; Varga F; Klaassen C D
Effect of lipoic acid on biliary excretion of glutathione and metals.
Toxicology and applied pharmacology 1992;114(1):88-96.
1992: Liu Y P; Liu J; Jia X S; Mao Q; Klaassen C D
Protective effects of fulvotomentosides on cadmium-induced hepatotoxicity.
Zhongguo yao li xue bao = Acta pharmacologica Sinica 1992;13(3):213-7.
1992: Liu Y P; Liu J; Jia X S; Mao Q; Madhu C; Klaassen C D
Protective effects of fulvotomentosides on acetaminophen-induced hepatotoxicity.
Zhongguo yao li xue bao = Acta pharmacologica Sinica 1992;13(3):209-12.
1992: Rozman P; Kim H J; Madhu C; Gregus Z; Klaassen C D
Homeostasis of sulfate and 3'-phosphoadenosine 5'-phosphosulfate in rats with deficient dietary intake of sulfur.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(3):374-8.
1992: Madhu C; Klaassen C D
Bromobenzene-glutathione excretion into bile reflects toxic activation of bromobenzene in rats.
Toxicology letters 1992;60(2):227-36.
1992: Barter R A; Klaassen C D
UDP-glucuronosyltransferase inducers reduce thyroid hormone levels in rats by an extrathyroidal mechanism.
Toxicology and applied pharmacology 1992;113(1):36-42.
1992: Gregus Z; Fekete T; Varga F; Klaassen C D
Availability of glycine and coenzyme A limits glycine conjugation in vivo.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(2):234-40.
1992: Rozman P; Kim H J; Madhu C; Klaassen C D
Tissue sulfate determination by ion chromatography.
Journal of chromatography 1992;574(1):146-9.
1992: Sendelbach L E; Kershaw W C; Cuppage F; Klaassen C D
Cd-metallothionein nephrotoxicity in inbred strains of mice.
Journal of toxicology and environmental health 1992;35(2):115-26.
1992: McKim J M; Liu J; Liu Y P; Klaassen C D
Distribution of cadmium chloride and cadmium-metallothionein to liver parenchymal, Kupffer, and endothelial cells: their relative ability to express metallothionein.
Toxicology and applied pharmacology 1992;112(2):324-30.
1992: McKim J M; Liu J; Liu Y P; Klaassen C D
Induction of metallothionein by cadmium-metallothionein in rat liver: a proposed mechanism.
Toxicology and applied pharmacology 1992;112(2):318-23.
1992: Kershaw W C; Klaassen C D
Degradation and metal composition of hepatic isometallothioneins in rats.
Toxicology and applied pharmacology 1992;112(1):24-31.
1992: Liu J; Kershaw W C; Klaassen C D
Protective effects of zinc on cultured rat primary hepatocytes to metals with low affinity for metallothionein.
Journal of toxicology and environmental health 1992;35(1):51-62.
1991: Maziasz T J; Liu J; Madhu C; Klaassen C D
The differential effects of hepatotoxicants on the sulfation pathway in rats.
Toxicology and applied pharmacology 1991;110(3):365-73.
1991: Bauman J W; Liu J; Liu Y P; Klaassen C D
Increase in metallothionein produced by chemicals that induce oxidative stress.
Toxicology and applied pharmacology 1991;110(2):347-54.
1991: Madhu C; Klaassen C D
Protective effect of pregnenolone-16 alpha-carbonitrile on acetaminophen-induced hepatotoxicity in hamsters.
Toxicology and applied pharmacology 1991;109(2):305-13.
1991: Howell S R; Klaassen C
Circadian variation of hepatic UDP-glucuronic acid and the glucuronidation of xenobiotics in mice.
Toxicology letters 1991;57(1):73-9.
1991: Goon D; Klaassen C D
Intestinal biotransformation of harmol and 1-naphthol in the rat. Further evidence of dose-dependent phase-II conjugation in situ.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(2):340-7.
1991: Liu J; Kershaw W C; Klaassen C D
The protective effect of metallothionein on the toxicity of various metals in rat primary hepatocyte culture.
Toxicology and applied pharmacology 1991;107(1):27-34.
1991: Kershaw W C; Klaassen C D
Cadmium-induced elevation of hepatic isometallothionein concentrations in inbred strains of mice.
Chemico-biological interactions 1991;78(3):269-82.
1990: Kershaw W C; Iga T; Klaassen C D
Ethanol decreases cadmium hepatotoxicity in rats: possible role of hepatic metallothionein induction.
Toxicology and applied pharmacology 1990;106(3):448-55.
1990: Kershaw W C; Lehman-McKeeman L D; Klaassen C D
Hepatic isometallothioneins in mice: induction in adults and postnatal ontogeny.
Toxicology and applied pharmacology 1990;104(2):267-75.
1990: Sendelbach L E; White C A; Howell S; Gregus Z; Klaassen C D
Effect of sulfhydryl-deficient diets on hepatic metallothionein, glutathione, and adenosine 3'-phosphate 5'-phosphosulfate (PAPS) levels in rats.
Toxicology and applied pharmacology 1990;102(2):259-67.
1990: Liu J; Kershaw W C; Klaassen C D
Rat primary hepatocyte cultures are a good model for examining metallothionein-induced tolerance to cadmium toxicity.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1990;26(1):75-9.
1990: Goon D; Klaassen C D
Dose-dependent intestinal glucuronidation and sulfation of acetaminophen in the rat in situ.
The Journal of pharmacology and experimental therapeutics 1990;252(1):201-7.
1990: Gregus Z; Madhu C; Klaassen C D
Effect of microsomal enzyme inducers on biliary and urinary excretion of acetaminophen metabolites in rats. Decreased hepatobiliary and increased hepatovascular transport of acetaminophen-glucuronide after microsomal enzyme induction.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(1):10-9.
1989: Goon D; Klaassen C D
Dosage-dependent absorption of cadmium in the rat intestine measured in situ.
Toxicology and applied pharmacology 1989;100(1):41-50.
1989: Klaassen C D; Lehman-McKeeman L D
Regulation of the isoforms of metallothionein.
Biological trace element research 1989;21():119-29.
1989: Sendelbach L E; Bracken W M; Klaassen C D
Comparisons of the toxicity of CdCl2 and Cd-metallothionein in isolated rat hepatocytes.
Toxicology 1989;55(1-2):83-91.
1989: Madhu C; Gregus Z; Klaassen C D
Biliary excretion of acetaminophen-glutathione as an index of toxic activation of acetaminophen: effect of chemicals that alter acetaminophen hepatotoxicity.
The Journal of pharmacology and experimental therapeutics 1989;248(3):1069-77.
1989: Gregus Z; Madhu C; Klaassen C D
Inducibility of glutathione S-transferases in hamsters.
Cancer letters 1989;44(2):89-94.
1988: Gregus Z; White C; Howell S; Klaassen C D
Effect of glutathione depletion on sulfate activation and sulfate ester formation in rats.
Biochemical pharmacology 1988;37(22):4307-12.
1988: Gregus Z; Madhu C; Goon D; Klaassen C D
Effect of galactosamine-induced hepatic UDP-glucuronic acid depletion on acetaminophen elimination in rats. Dispositional differences between hepatically and extrahepatically formed glucuronides of acetaminophen and other chemicals.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(4):527-33.
1988: Stein A F; Gregus Z; Klaassen C D
Species variations in biliary excretion of glutathione-related thiols and methylmercury.
Toxicology and applied pharmacology 1988;93(3):351-9.
1988: Howell S R; Kotkoskie L A; Dills R L; Klaassen C D
3-Hydroxylation of salicylamide in mice.
Journal of pharmaceutical sciences 1988;77(4):309-13.
1988: Gregus Z; Klaassen C D
Effect of butylated hydroxyanisole on hepatic glucuronidation and biliary excretion of drugs in mice.
The Journal of pharmacy and pharmacology 1988;40(4):237-42.
1988: Maitani T; Cuppage F E; Klaassen C D
Nephrotoxicity of intravenously injected cadmium-metallothionein: critical concentration and tolerance.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1988;10(1):98-108.
1988: Lehman-McKeeman L D; Andrews G K; Klaassen C D
Induction of hepatic metallothioneins determined at isoprotein and messenger RNA levels in glucocorticoid-treated rats.
The Biochemical journal 1988;249(2):429-33.
1988: Sendelbach L E; Klaassen C D
Kidney synthesizes less metallothionein than liver in response to cadmium chloride and cadmium-metallothionein.
Toxicology and applied pharmacology 1988;92(1):95-102.
1988: Lehman-McKeeman L D; Andrews G K; Klaassen C D
Ontogeny and induction of hepatic isometallothioneins in immature rats.
Toxicology and applied pharmacology 1988;92(1):10-7.
1988: Lehman-McKeeman L D; Andrews G K; Klaassen C D
Mechanisms of regulation of rat hepatic metallothionein-I and metallothionein-II levels following administration of zinc.
Toxicology and applied pharmacology 1988;92(1):1-9.
1988: Gregus Z; Madhu C; Klaassen C D
Species variation in toxication and detoxication of acetaminophen in vivo: a comparative study of biliary and urinary excretion of acetaminophen metabolites.
The Journal of pharmacology and experimental therapeutics 1988;244(1):91-9.
1988: Hazelton G A; Klaassen C D
UDP-glucuronosyltransferase activity toward digitoxigenin-monodigitoxoside. Differences in activation and induction properties in rat and mouse liver.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(1):30-6.
1987: Arlotto M P; Sonderfan A J; Klaassen C D; Parkinson A
Studies on the pregnenolone-16 alpha-carbonitrile-inducible form of rat liver microsomal cytochrome P-450 and UDP-glucuronosyltransferase.
Biochemical pharmacology 1987;36(22):3859-66.
1987: Gregus Z; Stein A F; Klaassen C D
Effect of inhibition of gamma-glutamyltranspeptidase on biliary and urinary excretion of glutathione-derived thiols and methylmercury.
The Journal of pharmacology and experimental therapeutics 1987;242(1):27-32.
1987: Gregus Z; Stein A F; Klaassen C D
Age-dependent biliary excretion of glutathione-related thiols in rats: role of gamma-glutamyltransferase.
The American journal of physiology 1987;253(1 Pt 1):G86-92.
1987: Dills R L; Howell S R; Klaassen C D
Hepatic UDP-glucose and UDP-glucuronic acid synthesis rates in rats during a reduced energy state.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(3):281-8.
1987: Bracken W M; Klaassen C D
Induction of metallothionein in rat primary hepatocyte cultures: evidence for direct and indirect induction.
Journal of toxicology and environmental health 1987;22(2):163-74.
1987: Klaassen C D; Waalkes M P
Cadmium-binding proteins in rat testes: characterization and apparent source of the low-molecular-weight protein.
Experientia. Supplementum 1987;52():273-80.

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