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Curtis Klaassen

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Lillian C Becker; Donald V Belsito; Wilma F Bergfeld; Ronald A Hill; Curtis D Klaassen; Daniel Liebler; James G Marks; Ronald C Shank; Thomas J Slaga; Paul W Snyder; F Alan Andersen
Safety assessment of silylates and surface-modified siloxysilicates.
Monice M Fiume; Bart Heldreth; Ronald A Hill; Curtis D Klaassen; Daniel Liebler; James G Marks; Ronald C Shank; Thomas J Slaga; Paul W Snyder; Donald V Belsito; Wilma F Bergfeld; F Alan Andersen
Safety assessment of triethanolamine and triethanolamine-containing ingredients as used in cosmetics.
Monice M Fiume; Bart Heldreth; Ronald A Hill; Curtis D Klaassen; Daniel C Liebler; James G Marks; Ronald C Shank; Thomas J Slaga; Paul W Snyder; Donald V Belsito; Wilma F Bergfeld; F Alan Andersen
Safety assessment of diethanolamides as used in cosmetics.

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2013: Lillian C Becker; Donald V Belsito; Wilma F Bergfeld; Ronald A Hill; Curtis D Klaassen; Daniel Liebler; James G Marks; Ronald C Shank; Thomas J Slaga; Paul W Snyder; F Alan Andersen
Safety assessment of silylates and surface-modified siloxysilicates.
International journal of toxicology 2013;32(3 Suppl):5S-24S.
2013: Monice M Fiume; Bart Heldreth; Ronald A Hill; Curtis D Klaassen; Daniel Liebler; James G Marks; Ronald C Shank; Thomas J Slaga; Paul W Snyder; Donald V Belsito; Wilma F Bergfeld; F Alan Andersen
Safety assessment of triethanolamine and triethanolamine-containing ingredients as used in cosmetics.
International journal of toxicology 2013;32(3 Suppl):59S-83S.
2013: Monice M Fiume; Bart Heldreth; Ronald A Hill; Curtis D Klaassen; Daniel C Liebler; James G Marks; Ronald C Shank; Thomas J Slaga; Paul W Snyder; Donald V Belsito; Wilma F Bergfeld; F Alan Andersen
Safety assessment of diethanolamides as used in cosmetics.
International journal of toxicology 2013;32(3 Suppl):36S-58S.
2013: Christina L Burnett; Ronald A Hill; Curtis D Klaassen; Daniel Liebler; James G Marks; Ronald C Shank; Thomas J Slaga; Paul W Snyder; Donald V Belsito; Wilma F Bergfeld; F Alan Andersen
Safety assessment of 2-amino-4-hydroxyethylaminoanisole and 2-amino-4-hydroxyethylaminoanisole sulfate as used in cosmetics.
International journal of toxicology 2013;32(3 Suppl):25S-35S.
2013: Feng Li; Jie Lu; Tsutomu Matsubara; Laiyou Wang; Jie Cheng; Iván L Csanaky; Frank J Gonzalez; Curtis D Klaassen; Xiaochao Ma
Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy.
Nature medicine 2013;19(4):418-20.
2013: Hong Lu; Byunggil Yoo; Xiao-bo Zhong; Julia Y Cui; Sumedha Gunewardena; Curtis D Klaassen
RNA-sequencing quantification of hepatic ontogeny and tissue distribution of mRNAs of phase II enzymes in mice.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(4):844-57.
2013: Yu-Kun Jennifer Zhang; Hong Lu; Curtis D Klaassen
Expression of human CAR splicing variants in BAC-transgenic mice.
Toxicological sciences : an official journal of the Society of Toxicology 2013;132(1):142-50.
2013: Yu-Kun Jennifer Zhang; Kai Connie Wu; Curtis D Klaassen
Genetic activation of Nrf2 protects against fasting-induced oxidative stress in livers of mice.
PloS one 2013;8(3):e59122.
2012: Lauren M Aleksunes; Julia Yue Cui; Xia Wen; Ronnie L Yeager; Curtis D Klaassen
Repression of hepatobiliary transporters and differential regulation of classic and alternative bile acid pathways in mice during pregnancy.
Toxicological sciences : an official journal of the Society of Toxicology 2012;130(2):257-68.
2012: Lillian C 'Becker; Donald V Belsito; Wilma F Bergfeld; Ronald A Hill; Curtis D Klaassen; Daniel Liebler; James G Marks; Ronald C Shank; Thomas J Slaga; Paul W Snyder; F Alan Andersen
Safety assessment of alkyl benzoates as used in cosmetics.
International journal of toxicology 2012;31(6 Suppl):342S-72S.
2012: Lillian C Becker; Donald V Belsito; Wilma F Bergfeld; Ronald A Hill; Curtis D Klaassen; Daniel Liebler; James G Marks; Ronald C Shank; Thomas J Slaga; Paul W Snyder; F Alan Andersen
Safety assessment of trimoniums as used in cosmetics.
International journal of toxicology 2012;31(6 Suppl):296S-341S.
2012: Wilbur Johnson; Curtis D Klaassen; Daniel Liebler; James G Marks; Ronald C Shank; Thomas J Slaga; Paul W Snyder; Donald V Belsito; Wilma F Bergfeld; Ronald A Hill; F Alan Andersen
Safety assessment of isoparaffins as used in cosmetics.
International journal of toxicology 2012;31(6 Suppl):269S-95S.
2012: Yu-Kun Jennifer Zhang; Jie Liu; Kai Connie Wu; Curtis D Klaassen
Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet.
Toxicology and applied pharmacology 2012;264(3):305-14.
2012: Kai Connie Wu; Youcai Zhang; Curtis D Klaassen
Nrf2 protects against diquat-induced liver and lung injury.
Free radical research 2012;46(10):1220-9.
2012: Monice M Fiume; Ronald A Hill; Curtis D Klaassen; Daniel Liebler; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; Donald V Belsito; Wilma F Bergfeld; F Alan Andersen
Safety assessment of propylene glycol, tripropylene glycol, and PPGs as used in cosmetics.
International journal of toxicology 2012;31(5 Suppl):245S-60S.
2012: Monice M Fiume; Bart Heldreth; Ronald A Hill; Curtis D Klaassen; Daniel Liebler; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; Donald V Belsito; Wilma F Bergfeld; F Alan Andersen
Safety assessment of alkyl PEG ethers as used in cosmetics.
International journal of toxicology 2012;31(5 Suppl):169S-244S.
2012: Wilbur Johnson; Curtis D Klaassen; Daniel Liebler; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; Donald V Belsito; Wilma F Bergfeld; Ronald A Hill; F Alan Andersen
Safety assessment of 1,2-glycols as used in cosmetics.
International journal of toxicology 2012;31(5 Suppl):147S-68S.
2012: Monice M Fiume; Ronald A Hill; Curtis D Klaassen; Daniel Liebler; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; Donald V Belsito; Wilma F Bergfeld; F Alan Andersen
Safety assessment of stearyl heptanoate and related stearyl alkanoates as used in cosmetics.
International journal of toxicology 2012;31(5 Suppl):141S-6S.
2012: Xingguo Cheng; Curtis D Klaassen
Hormonal and chemical regulation of paraoxonases in mice.
The Journal of pharmacology and experimental therapeutics 2012;342(3):688-95.
2012: Bo Kong; Li Wang; Youcai Zhang; John Y L Chiang; Curtis D Klaassen; Grace L Guo
Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice.
Hepatology (Baltimore, Md.) 2012;56(3):1034-43.
2012: Kai C Wu; Jie J Liu; Curtis D Klaassen
Nrf2 activation prevents cadmium-induced acute liver injury.
Toxicology and applied pharmacology 2012;263(1):14-20.
2012: Kai Connie Wu; Jie Liu; Curtis D Klaassen
Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation.
Toxicology and applied pharmacology 2012;262(3):321-9.
2012: Christina L Burnett; Ronald A Hill; Curtis D Klaassen; Daniel Liebler; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; Donald V Belsito; Wilma F Bergfeld; F Alan Andersen
Final report of the Cosmetic Ingredient Review Expert Panel on the safety assessment of cocamidopropyl betaine (CAPB).
International journal of toxicology 2012;31(4 Suppl):77S-111S.
2012: Monice M Fiume; Ronald A Hill; Curtis D Klaassen; Daniel Liebler; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; Bart Heldreth; Donald V Belsito; Wilma F Bergfeld; Hbart Eldreth; F Alan Andersen
Final report of the Cosmetic Ingredient Review Expert Panel on the safety assessment of dicarboxylic acids, salts, and esters.
International journal of toxicology 2012;31(4 Suppl):5S-76S.
2012: Bart Heldreth; Ronald A Hill; Curtis D Klaassen; Daniel Liebler; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; Donald V Belsito; Wilma F Bergfeld; F Alan Andersen
Final report of the Cosmetic Ingredient Review Expert Panel on the safety assessment of methyl acetate.
International journal of toxicology 2012;31(4 Suppl):112S-36S.
2012: Lauren M Aleksunes; Curtis D Klaassen
Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(7):1366-79.
2012: Bo Kong; Xiaochao Ma; Meghan Patni; Scott Weir; Lauren M Aleksunes; Melinda Broward; Qi Chen; Iván Csanaky; Hartmut Jaeschke; Curtis D Klaassen; Grace L Guo
Gender-specific reduction of hepatic Mrp2 expression by high-fat diet protects female mice from ANIT toxicity.
Toxicology and applied pharmacology 2012;261(2):189-95.
2012: Youcai Zhang; Lois D Lehman-McKeeman; Xingguo Cheng; Iván Csanaky; Curtis D Klaassen
Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury.
Toxicological sciences : an official journal of the Society of Toxicology 2012;127(2):451-62.
2012: Julia Yue Cui; Sumedha S Gunewardena; Jie Liu; Hong Lu; Helen J Renaud; Byunggil Yoo; Xiao-bo Zhong; Curtis D Klaassen
RNA-Seq reveals different mRNA abundance of transporters and their alternative transcript isoforms during liver development.
Toxicological sciences : an official journal of the Society of Toxicology 2012;127(2):592-608.
2012: Julia Yue Cui; Helen J Renaud; Curtis D Klaassen
Ontogeny of novel cytochrome P450 gene isoforms during postnatal liver maturation in mice.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(6):1226-37.
2012: Zidong Donna Fu; Iván L Csanaky; Curtis D Klaassen
Effects of aging on mRNA profiles for drug-metabolizing enzymes and transporters in livers of male and female mice.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(6):1216-25.
2012: Lai Peng; Byunggil Yoo; Sumedha S Gunewardena; Curtis D Klaassen; Hong Lu; Xiao-bo Zhong
RNA sequencing reveals dynamic changes of mRNA abundance of cytochromes P450 and their alternative transcripts during mouse liver development.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(6):1198-209.
2012: Youcai Zhang; Lauren M Aleksunes; Xingguo Cheng; Curtis D Klaassen
Transcription factor-mediated regulation of carboxylesterase enzymes in livers of mice.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(6):1191-7.
2012: Julia Yue Cui; Zidong Donna Fu; Grace L Guo; Ying Guo; Hong Lu; Yuji Tanaka; Xiao-bo Zhong; Lauren M Aleksunes; Curtis D Klaassen
Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice.
American journal of physiology. Gastrointestinal and liver physiology 2012;302(9):G979-96.
2012: L A Martin; K R Reuhl; D T Wilson; M A Gallo; Curtis D Klaassen
Polychlorinated biphenyl congeners that increase the glucuronidation and biliary excretion of thyroxine are distinct from the congeners that enhance the serum disappearance of thyroxine.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(3):588-95.
2012: Cheryl E Rockwell; Mingcai Zhang; Patrick E Fields; Curtis D Klaassen
Th2 skewing by activation of Nrf2 in CD4(+) T cells.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(4):1630-7.
2012: Tiangang Li; Adrian Ochoa; Youcai Zhang; Shannon Boehme; Sandra K Erickson; Jessica M Francl; Curtis D Klaassen; John Y L Chiang
Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity.
The Journal of biological chemistry 2012;287(3):1861-73.
2012: Kai Connie Wu; Rathnam Chaguturu; Jie Jerry Liu; Peter R McDonald; Curtis D Klaassen
Implementation of a high-throughput screen for identifying small molecules to activate the Keap1-Nrf2-ARE pathway.
PloS one 2012;7(10):e44686.
2012: Yi-Qiao Xu; Dan Zhang; Ding-Jun Cai; Tao Jin; Jie Liu; Yuanfu Lu; Qin Wu; Curtis D Klaassen
Diurnal variation of hepatic antioxidant gene expression in mice.
PloS one 2012;7(8):e44237.
2012: Kai Connie Wu; Julia Yue Cui; Curtis D Klaassen
Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver.
PloS one 2012;7(7):e39006.
2012: Youcai Zhang; Lois D Lehman-McKeeman; Pallavi B Limaye; Curtis D Klaassen
Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice.
PloS one 2012;7(4):e34522.
2012: Zidong Donna Fu; Iván L Csanaky; Curtis D Klaassen
Gender-divergent profile of bile acid homeostasis during aging of mice.
PloS one 2012;7(3):e32551.
2011: Wilma F Bergfeld; Ronald Hill; Curtis D Klaassen; Daniel Liebler; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; Donald V Belsito; F Alan Andersen
Safety assessment of xylene sulfonic acid, toluene sulfonic acid, and alkyl aryl sulfonate hydrotropes as used in cosmetics.
International journal of toxicology 2011;30(6 Suppl):270S-83S.
2011: Wilbur Johnson; Curtis D Klaassen; Daniel Liebler; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; Bart Heldreth; Donald V Belsito; Wilma F Bergfeld; Ronald Hill; F Alan Andersen
Final report of the Cosmetic Ingredient Review Expert Panel on the safety assessment of pelargonic acid (nonanoic acid) and nonanoate esters.
International journal of toxicology 2011;30(6 Suppl):228S-69S.
2011: Wilbur Johnson; Curtis D Klaassen; Daniel C Liebler; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; Donald V Belsito; Wilma F Bergfeld; Ronald A Hill; F Alan Andersen
Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane.
International journal of toxicology 2011;30(6 Suppl):149S-227S.
2011: Helen J Renaud; Julia Yue Cui; Mohammed Khan; Curtis D Klaassen
Tissue distribution and gender-divergent expression of 78 cytochrome P450 mRNAs in mice.
Toxicological sciences : an official journal of the Society of Toxicology 2011;124(2):261-77.
2011: Youcai Zhang; Lois D Lehman-McKeeman; Iván Csanaky; Curtis D Klaassen
Loss of organic anion transporting polypeptide 1a1 increases deoxycholic acid absorption in mice by increasing intestinal permeability.
Toxicological sciences : an official journal of the Society of Toxicology 2011;124(2):251-60.
2011: Erik Pacyniak; Bruno Hagenbuch; Curtis D Klaassen; Lois Lehman-McKeeman; Grace L Guo
Organic anion transporting polypeptides in the hepatic uptake of PBDE congeners in mice.
Toxicology and applied pharmacology 2011;257(1):23-31.
2011: Ying Guo; Feng Li; Xiaochao Ma; Honghao Zhou; Xingguo Cheng; Curtis D Klaassen
CYP2D plays a major role in berberine metabolism in liver of mice and humans.
Xenobiotica; the fate of foreign compounds in biological systems 2011;41(11):996-1005.
2011: Ying Guo; Chad Pope; Honghao Zhou; Xingguo Cheng; Curtis D Klaassen
Dose-response of berberine on hepatic cytochromes P450 mRNA expression and activities in mice.
Journal of ethnopharmacology 2011;138(1):111-8.
2011: Hong Lu; Wei Cui; Curtis D Klaassen
Nrf2 protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative injury and steatohepatitis.
Toxicology and applied pharmacology 2011;256(2):122-35.
2011: Christina L Burnett; Ronald A Hill; Curtis D Klaassen; Daniel C Liebler; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; Donald V Belsito; Wilma F Bergfeld; F Alan Andersen
Final report of the Amended Safety Assessment of PVM/MA copolymer and its related salts and esters as used in cosmetics.
International journal of toxicology 2011;30(5 Suppl):128S-44S.
2011: Kai Connie Wu; Julia Yue Cui; Curtis D Klaassen
Beneficial role of Nrf2 in regulating NADPH generation and consumption.
Toxicological sciences : an official journal of the Society of Toxicology 2011;123(2):590-600.
2011: Peizhen Song; Youcai Zhang; Curtis D Klaassen
Dose-response of five bile acids on serum and liver bile Acid concentrations and hepatotoxicty in mice.
Toxicological sciences : an official journal of the Society of Toxicology 2011;123(2):359-67.
2011: Lei Gong; Yong-Hae Han; Purnima Khandelwal; Curtis D Klaassen; Lloyd Lecureux; Nelly Aranibar; Vasanthi Bhaskaran; Youcai Zhang; Lois D Lehman-McKeeman
Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles.
Toxicological sciences : an official journal of the Society of Toxicology 2011;122(2):587-97.
2011: Curtis D Klaassen; Hong Lu; Julia Yue Cui
Epigenetic regulation of drug processing genes.
Toxicology mechanisms and methods 2011;21(4):312-24.
2011: Yazen Alnouti; Curtis D Klaassen
Mechanisms of gender-specific regulation of mouse sulfotransferases (Sults).
Xenobiotica; the fate of foreign compounds in biological systems 2011;41(3):187-97.
2011: Yu-Kun Jennifer Zhang; Grace L Guo; Curtis D Klaassen
Diurnal variations of mouse plasma and hepatic bile acid concentrations as well as expression of biosynthetic enzymes and transporters.
PloS one 2011;6(2):e16683.
2011: Iván Csanaky; Hong Lu; Youcai Zhang; Kenichiro Ogura; Supratim Choudhuri; Curtis D Klaassen
Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice.
Hepatology (Baltimore, Md.) 2011;53(1):272-81.
2010: Julia Yue Cui; Sumedha S Gunewardena; Cheryl E Rockwell; Curtis D Klaassen
ChIPing the cistrome of PXR in mouse liver.
Nucleic acids research 2010;38(22):7943-63.
2010: Lillian C Becker; Wilma F Bergfeld; Donald V Belsito; Ronald A Hill; Curtis D Klaassen; Daniel C Liebler; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; F Alan Andersen
Amended safety assessment of dodecylbenzenesulfonate, decylbenzenesulfonate, and tridecylbenzenesulfonate salts as used in cosmetics.
International journal of toxicology 2010;29(6 Suppl):288S-305.
2010: F Alan Andersen; Wilma F Bergfeld; Donald V Belsito; Ronald A Hill; Curtis D Klaassen; Daniel C Liebler; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder
Final amended safety assessment of hydroquinone as used in cosmetics.
International journal of toxicology 2010;29(6 Suppl):274S-87.
2010: Christina L Burnett; Wilma F Bergfeld; Donald V Belsito; Ronald A Hill; Curtis D Klaassen; Daniel C Liebler; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; F Alan Andersen
Final report of the safety assessment of Kojic acid as used in cosmetics.
International journal of toxicology 2010;29(6 Suppl):244S-73.
2010: F Alan Andersen; Wilma F Bergfeld; Donald V Belsito; Ronald A Hill; Curtis D Klaassen; Daniel C Liebler; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder
Final report of the Cosmetic Ingredient Review Expert Panel amended safety assessment of Calendula officinalis-derived cosmetic ingredients.
International journal of toxicology 2010;29(6 Suppl):221S-43.
2010: Youcai Zhang; Curtis D Klaassen
Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice.
Journal of lipid research 2010;51(11):3230-42.
2010: Terrilyn A Richardson; Curtis D Klaassen
Disruption of thyroid hormone homeostasis in Ugt1a-deficient Gunn rats by microsomal enzyme inducers is not due to enhanced thyroxine glucuronidation.
Toxicology and applied pharmacology 2010;248(1):38-44.
2010: Lauren M Aleksunes; Michael J Goedken; Cheryl E Rockwell; Juergen Thomale; José E Manautou; Curtis D Klaassen
Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity.
The Journal of pharmacology and experimental therapeutics 2010;335(1):2-12.
2010: Lori Martin; Curtis D Klaassen
Differential effects of polychlorinated biphenyl congeners on serum thyroid hormone levels in rats.
Toxicological sciences : an official journal of the Society of Toxicology 2010;117(1):36-44.
2010: Terrilyn A Richardson; Curtis D Klaassen
Role of UDP-glucuronosyltransferase (UGT) 2B2 in metabolism of triiodothyronine: effect of microsomal enzyme inducers in Sprague Dawley and UGT2B2-deficient Fischer 344 rats.
Toxicological sciences : an official journal of the Society of Toxicology 2010;116(2):413-21.
2010: Christina L Burnett; Wilma F Bergfeld; Donald V Belsito; Curtis D Klaassen; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; F Alan Andersen
Final report of the safety assessment of methylisothiazolinone.
International journal of toxicology 2010;29(4 Suppl):187S-213S.
2010: Lillian C Becker; Wilma F Bergfeld; Donald V Belsito; Ronald A Hill; Curtis D Klaassen; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; F Alan Andersen
Final report of the amended safety assessment of myristic acid and its salts and esters as used in cosmetics.
International journal of toxicology 2010;29(4 Suppl):162S-86S.
2010: Valerie C Robinson; Wilma F Bergfeld; Donald V Belsito; Ronald A Hill; Curtis D Klaassen; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; F Alan Andersen
Final report of the amended safety assessment of sodium laureth sulfate and related salts of sulfated ethoxylated alcohols.
International journal of toxicology 2010;29(4 Suppl):151S-61S.
2010: Catherine Diamante; Monice Zondlo Fiume; Wilma F Bergfeld; Donald V Belsito; Ronald A Hill; Curtis D Klaassen; Daniel C Liebler; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; F Alan Andersen
Final safety assessment of thiodipropionic acid and its dialkyl esters as used in cosmetics.
International journal of toxicology 2010;29(4 Suppl):137S-50S.
2010: Julia Yue Cui; Supratim Choudhuri; Tamara R Knight; Curtis D Klaassen
Genetic and epigenetic regulation and expression signatures of glutathione S-transferases in developing mouse liver.
Toxicological sciences : an official journal of the Society of Toxicology 2010;116(1):32-43.
2010: Yu-Kun Jennifer Zhang; Kurt W Saupe; Curtis D Klaassen
Energy restriction does not compensate for the reduced expression of hepatic drug-processing genes in mice with aging.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(7):1122-31.
2010: Supratim Choudhuri; Yue Cui; Curtis D Klaassen
Molecular targets of epigenetic regulation and effectors of environmental influences.
Toxicology and applied pharmacology 2010;245(3):378-93.
2010: Yu-Kun Jennifer Zhang; Ronnie L Yeager; Yuji Tanaka; Curtis D Klaassen
Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet.
Toxicology and applied pharmacology 2010;245(3):326-34.
2010: Monice Fiume; Wilma F Bergfeld; Donald V Belsito; Curtis D Klaassen; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; F Alan Andersen
Final report on the safety assessment of sodium cetearyl sulfate and related alkyl sulfates as used in cosmetics.
International journal of toxicology 2010;29(3 Suppl):115S-32S.
2010: Lillian C Becker; Wilma F Bergfeld; Donald V Belsito; Curtis D Klaassen; Ronald Hill; Daniel Leibler; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; F Alan Andersen
Final report of the amended safety assessment of Quaternium-15 as used in cosmetics.
International journal of toxicology 2010;29(3 Suppl):98S-114S.
2010: Lillian C Becker; Wilma F Bergfeld; Donald V Belsito; Curtis D Klaassen; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; F Alan Andersen
Final report of the safety assessment of allantoin and its related complexes.
International journal of toxicology 2010;29(3 Suppl):84S-97S.
2010: Christina L Burnett; Wilma F Bergfeld; Donald V Belsito; Curtis D Klaassen; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; F Alan Andersen
Final amended report of the safety assessment of toluene-2,5-diamine, toluene-2,5-diamine sulfate, and toluene-3,4-diamine as used in cosmetics.
International journal of toxicology 2010;29(3 Suppl):61S-83S.
2010: Bryan L Copple; Hartmut Jaeschke; Curtis D Klaassen
Oxidative stress and the pathogenesis of cholestasis.
Seminars in liver disease 2010;30(2):195-204.
2010: Curtis D Klaassen; Scott A Reisman
Nrf2 the rescue: effects of the antioxidative/electrophilic response on the liver.
Toxicology and applied pharmacology 2010;244(1):57-65.
2010: Lauren M Aleksunes; Scott A Reisman; Ronnie L Yeager; Michael J Goedken; Curtis D Klaassen
Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice.
The Journal of pharmacology and experimental therapeutics 2010;333(1):140-51.
2010: Jeff L Staudinger; Chenshu Xu; Yue J Cui; Curtis D Klaassen
Nuclear receptor-mediated regulation of carboxylesterase expression and activity.
Expert opinion on drug metabolism & toxicology 2010;6(3):261-71.
2010: Curtis D Klaassen; Lauren M Aleksunes
Xenobiotic, bile acid, and cholesterol transporters: function and regulation.
Pharmacological reviews 2010;62(1):1-96.
2010: Hongzu Ren; Lauren M Aleksunes; Carmen Wood; Beena Vallanat; Michael H George; Curtis D Klaassen; J Christopher Corton
Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor.
Toxicological sciences : an official journal of the Society of Toxicology 2010;113(1):45-59.
2009: Valerie Robinson; Wilma F Bergfeld; Donald V Belsito; Curtis D Klaassen; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; F Alan Andersen
Amended safety assessment of tall oil acid, sodium tallate, potassium tallate, and ammonium tallate.
International journal of toxicology 2009;28(6 Suppl 2):252S-8S.
2009: Christina L Burnett; Wilma F Bergfeld; Donald V Belsito; Curtis D Klaassen; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; F Alan Andersen
Final report on the safety assessment of amino nitrophenols as used in hair dyes.
International journal of toxicology 2009;28(6 Suppl 2):217S-51S.
2009: Lillian C Becker; Wilma F Bergfeld; Donald V Belsito; Curtis D Klaassen; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; F Alan Andersen
Amended safety assessment of sodium picramate and picramic acid.
International journal of toxicology 2009;28(6 Suppl 2):205S-16S.
2009: Catherine Diamante; Wilma F Bergfeld; Donald V Belsito; Curtis D Klaassen; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; F Alan Andersen
Final report on the safety assessment of Basic Violet 1, Basic Violet 3, and Basic Violet 4.
International journal of toxicology 2009;28(6 Suppl 2):193S-204S.
2009: Valerie Robinson; Wilma F Bergfeld; Donald V Belsito; Curtis D Klaassen; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; F Alan Andersen
Final report on the safety assessment of Piper methysticum leaf/root/stem extract and Piper methysticum root extract.
International journal of toxicology 2009;28(6 Suppl):175S-88S.
2009: Valerie Robinson; Wilma F Bergfeld; Donald V Belsito; Curtis D Klaassen; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; F Alan Andersen
Final report on the safety assessment of PPG-2 methyl ether, PPG-3 methyl ether, and PPG-2 methyl ether acetate.
International journal of toxicology 2009;28(6 Suppl):162S-74S.
2009: Christina L Burnett; Wilma F Bergfeld; Donald V Belsito; Curtis D Klaassen; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; F Alan Andersen
Final amended report on safety assessment on aminomethyl propanol and aminomethyl propanediol.
International journal of toxicology 2009;28(6 Suppl):141S-61S.
2009: Xingguo Cheng; Curtis D Klaassen
Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(11):2178-85.
2009: Ronnie L Yeager; Scott A Reisman; Lauren M Aleksunes; Curtis D Klaassen
Introducing the "TCDD-inducible AhR-Nrf2 gene battery".
Toxicological sciences : an official journal of the Society of Toxicology 2009;111(2):238-46.
2009: Yue Julia Cui; Ronnie L Yeager; Xiao-Bo Zhong; Curtis D Klaassen
Ontogenic expression of hepatic Ahr mRNA is associated with histone H3K4 di-methylation during mouse liver development.
Toxicology letters 2009;189(3):184-90.
2009: Ye Li; David Buckley; Shuang Wang; Curtis D Klaassen; Xiao-bo Zhong
Genetic polymorphisms in the TATA box and upstream phenobarbital-responsive enhancer module of the UGT1A1 promoter have combined effects on UDP-glucuronosyltransferase 1A1 transcription mediated by constitutive androstane receptor, pregnane X receptor, or glucocorticoid receptor in human liver.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(9):1978-86.
2009: Iván Csanaky; Lauren M Aleksunes; Yuji Tanaka; Curtis D Klaassen
Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice.
American journal of physiology. Gastrointestinal and liver physiology 2009;297(3):G419-33.
2009: Curtis D Klaassen; Jie Liu; Bhalchandra A Diwan
Metallothionein protection of cadmium toxicity.
Toxicology and applied pharmacology 2009;238(3):215-20.
2009: Lisa D Beilke; Lauren M Aleksunes; Erik R Olson; David G Besselsen; Curtis D Klaassen; Katerina Dvorak; Nathan J Cherrington
Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.
Toxicology letters 2009;188(1):38-44.
2009: Christina L Burnett; Wilma F Bergfeld; Donald V Belsito; Curtis D Klaassen; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; F Alan Andersen
Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl Thioglycolate, Isopropyl Thioglycolate, Magnesium Thioglycolate, Methyl Thioglycolate, Potassium Thioglycolate, Sodium Thioglycolate, and Thioglycolic Acid.
International journal of toxicology 2009;28(4 Suppl):68-133.
2009: Lillian C Becker; Wilma F Bergfeld; Donald V Belsito; Curtis D Klaassen; James G Marks; Ronald C Shank; Thomas Slaga; Paul W Snyder; F Alan Andersen
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
International journal of toxicology 2009;28(4 Suppl):5-67.
2009: Lauren M Aleksunes; R L Yeager; Curtis D Klaassen
Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human livers.
Xenobiotica; the fate of foreign compounds in biological systems 2009;39(7):514-22.
2009: Yue J Cui; Lauren M Aleksunes; Yuji Tanaka; Michael J Goedken; Curtis D Klaassen
Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice.
Toxicological sciences : an official journal of the Society of Toxicology 2009;110(1):47-60.
2009: Scott A Reisman; Iván Csanaky; Lauren M Aleksunes; Curtis D Klaassen
Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice.
Toxicological sciences : an official journal of the Society of Toxicology 2009;109(1):31-40.
2009: Scott A Reisman; Iván Csanaky; Ronnie L Yeager; Curtis D Klaassen
Nrf2 activation enhances biliary excretion of sulfobromophthalein by inducing glutathione-S-transferase activity.
Toxicological sciences : an official journal of the Society of Toxicology 2009;109(1):24-30.
2009: Lisa D Beilke; Lauren M Aleksunes; Ricky D Holland; David G Besselsen; Richard Beger; Curtis D Klaassen; Nathan J Cherrington
Constitutive androstane receptor-mediated changes in bile acid composition contributes to hepatoprotection from lithocholic acid-induced liver injury in mice.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(5):1035-45.
2009: Ye Li; Yue Cui; Steven N Hart; Curtis D Klaassen; Xiao-bo Zhong
Dynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturation.
Molecular pharmacology 2009;75(5):1171-9.
2009: Xiaoxia Yang; Yu-Kun Jennifer Zhang; Noriko Esterly; Curtis D Klaassen; Yu-Jui Yvonne Wan
Gender disparity of hepatic lipid homoeostasis regulated by the circadian clock.
Journal of biochemistry 2009;145(5):609-23.
2009: Scott A Reisman; David B Buckley; Yuji Tanaka; Curtis D Klaassen
CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes.
Toxicology and applied pharmacology 2009;236(1):109-14.
2009: Scott A Reisman; Lauren M Aleksunes; Curtis D Klaassen
Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes.
Biochemical pharmacology 2009;77(7):1273-82.
2009: Lloyd Lecureux; Matthew Z Dieter; David M Nelson; Linda Watson; Harvey Wong; Brian Gemzik; Curtis D Klaassen; Lois D Lehman-McKeeman
Hepatobiliary disposition of thyroid hormone in Mrp2-deficient TR- rats: reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism.
Toxicological sciences : an official journal of the Society of Toxicology 2009;108(2):482-91.
2009: Yuji Tanaka; Lauren M Aleksunes; Yue Julia Cui; Curtis D Klaassen
ANIT-induced intrahepatic cholestasis alters hepatobiliary transporter expression via Nrf2-dependent and independent signaling.
Toxicological sciences : an official journal of the Society of Toxicology 2009;108(2):247-57.
2009: David B Buckley; Curtis D Klaassen
Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear factor erythroid 2-related factor 2.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(4):847-56.
2009: David B Buckley; Curtis D Klaassen
Mechanism of gender-divergent UDP-glucuronosyltransferase mRNA expression in mouse liver and kidney.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(4):834-40.
2009: Scott A Reisman; Ronnie L Yeager; Masayuki Yamamoto; Curtis D Klaassen
Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species.
Toxicological sciences : an official journal of the Society of Toxicology 2009;108(1):35-47.
2009: Maxwell Afari Gyamfi; Yuji Tanaka; Lin He; Curtis D Klaassen; Yu-Jui Yvonne Wan
Hepatic effects of a methionine-choline-deficient diet in hepatocyte RXRalpha-null mice.
Toxicology and applied pharmacology 2009;234(2):166-78.
2008: Jonathan M Maher; Lauren M Aleksunes; Matthew Z Dieter; Yuji Tanaka; Jeffrey M Peters; José E Manautou; Curtis D Klaassen
Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid.
Toxicological sciences : an official journal of the Society of Toxicology 2008;106(2):319-28.
2008: Tamara R Knight; Supratim Choudhuri; Curtis D Klaassen
Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers.
Toxicological sciences : an official journal of the Society of Toxicology 2008;106(2):329-38.
2008: Xingguo Cheng; Curtis D Klaassen
Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers.
Toxicological sciences : an official journal of the Society of Toxicology 2008;106(1):37-45.
2008: Xingguo Cheng; Curtis D Klaassen
Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors.
Toxicological sciences : an official journal of the Society of Toxicology 2008;106(1):29-36.
2008: Yazen Alnouti; Iván Csanaky; Curtis D Klaassen
Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;873(2):209-17.
2008: Yuji Tanaka; Lauren M Aleksunes; Michael J Goedken; Chuan Chen; Scott A Reisman; José E Manautou; Curtis D Klaassen
Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity.
Toxicology and applied pharmacology 2008;231(3):364-73.
2008: Lauren M Aleksunes; Yue Cui; Curtis D Klaassen
Prominent expression of xenobiotic efflux transporters in mouse extraembryonic fetal membranes compared with placenta.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(9):1960-70.
2008: Matthew D Merrell; Jonathan P Jackson; Lisa M Augustine; Craig D Fisher; Angela L Slitt; Jonathan M Maher; Wendong Huang; David D Moore; Youcai Zhang; Curtis D Klaassen; Nathan J Cherrington
The Nrf2 activator oltipraz also activates the constitutive androstane receptor.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(8):1716-21.
2008: Andrew J Lickteig; Xingguo Cheng; Lisa M Augustine; Curtis D Klaassen; Nathan J Cherrington
Tissue distribution, ontogeny and induction of the transporters Multidrug and toxin extrusion (MATE) 1 and MATE2 mRNA expression levels in mice.
Life sciences 2008;83(1-2):59-64.
2008: Nick Plant; Curtis D Klaassen
Editorial overview. Xenobiotic and endobiotic transporters: structure, function and regulation.
Xenobiotica; the fate of foreign compounds in biological systems 2008;38(7-8):654-5.
2008: Hong Lu; Supratim Choudhuri; Kenichiro Ogura; Iván Csanaky; Xiaohong Lei; Xingguo Cheng; Pei-zhen Song; Curtis D Klaassen
Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR.
Toxicological sciences : an official journal of the Society of Toxicology 2008;103(1):35-45.
2008: Yuji Tanaka; Lauren M Aleksunes; Ronnie L Yeager; Maxwell Afari Gyamfi; Noriko Esterly; Grace L Guo; Curtis D Klaassen
NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet.
The Journal of pharmacology and experimental therapeutics 2008;325(2):655-64.
2008: Yazen Alnouti; Curtis D Klaassen
Regulation of sulfotransferase enzymes by prototypical microsomal enzyme inducers in mice.
The Journal of pharmacology and experimental therapeutics 2008;324(2):612-21.
2008: Curtis D Klaassen; Hong Lu
Xenobiotic transporters: ascribing function from gene knockout and mutation studies.
Toxicological sciences : an official journal of the Society of Toxicology 2008;101(2):186-96.
2008: Yazen Alnouti; Curtis D Klaassen
Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice.
Toxicological sciences : an official journal of the Society of Toxicology 2008;101(1):51-64.
2008: Yuji Tanaka; Chuan Chen; Jonathan M Maher; Curtis D Klaassen
Ischemia-reperfusion of rat livers decreases liver and increases kidney multidrug resistance associated protein 2 (Mrp2).
Toxicological sciences : an official journal of the Society of Toxicology 2008;101(1):171-8.
2008: Lauren M Aleksunes; Angela L Slitt; Jonathan M Maher; Lisa M Augustine; Michael Goedken; Jefferson Y Chan; Nathan J Cherrington; Curtis D Klaassen; José E Manautou
Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2.
Toxicology and applied pharmacology 2008;226(1):74-83.
2007: Xingguo Cheng; David Buckley; Curtis D Klaassen
Regulation of hepatic bile acid transporters Ntcp and Bsep expression.
Biochemical pharmacology 2007;74(11):1665-76.
2007: Tamara Raphael Knight; Supratim Choudhuri; Curtis D Klaassen
Constitutive mRNA expression of various glutathione S-transferase isoforms in different tissues of mice.
Toxicological sciences : an official journal of the Society of Toxicology 2007;100(2):513-24.
2007: Jonathan M Maher; Matthew Z Dieter; Lauren M Aleksunes; Angela L Slitt; Grace Guo; Yuji Tanaka; George L Scheffer; Jefferson Y Chan; José E Manautou; Ying Chen; Timothy P Dalton; Masayuki Yamamoto; Curtis D Klaassen
Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway.
Hepatology (Baltimore, Md.) 2007;46(5):1597-610.
2007: Jay S Petrick; Curtis D Klaassen
Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transport.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(10):1806-15.
2007: Craig D Fisher; Lisa M Augustine; Jonathan M Maher; David M Nelson; Angela L Slitt; Curtis D Klaassen; Lois D Lehman-McKeeman; Nathan J Cherrington
Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive androstane receptor and nuclear factor E2-related factor 2.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(6):995-1000.
2007: Erik K Pacyniak; Xingguo Cheng; Michael L Cunningham; Kevin Crofton; Curtis D Klaassen; Grace L Guo
The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators.
Toxicological sciences : an official journal of the Society of Toxicology 2007;97(1):94-102.
2007: Dong-Won Kim; Ki-Young Kim; Byung Sun Choi; Pilju Youn; Doug-Young Ryu; Curtis D Klaassen; Jung-Duck Park
Regulation of metal transporters by dietary iron, and the relationship between body iron levels and cadmium uptake.
Archives of toxicology 2007;81(5):327-34.
2007: Chuan Chen; Xingguo Cheng; Matthew Z Dieter; Yuji Tanaka; Curtis D Klaassen
Activation of cAMP-dependent signaling pathway induces mouse organic anion transporting polypeptide 2 expression.
Molecular pharmacology 2007;71(4):1159-64.
2007: Yuji Tanaka; Jonathan M Maher; Chuan Chen; Curtis D Klaassen
Hepatic ischemia-reperfusion induces renal heme oxygenase-1 via NF-E2-related factor 2 in rats and mice.
Molecular pharmacology 2007;71(3):817-25.
2007: Angela L Slitt; Katryn Allen; Jennifer Morrone; Lauren M Aleksunes; Chuan Chen; Jonathan M Maher; José E Manautou; Nathan J Cherrington; Curtis D Klaassen
Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis.
Biochimica et biophysica acta 2007;1768(3):637-47.
2007: Jeffrey S Moffit; Lauren M Aleksunes; Michael J Kardas; Angela L Slitt; Curtis D Klaassen; José E Manautou
Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen.
Toxicology 2007;230(2-3):197-206.
2007: Kaori Nakamoto; Judith R Kidd; Robert D Jenison; Curtis D Klaassen; Yu-Jui Yvonne Wan; Kenneth K Kidd; Xiao-bo Zhong
Genotyping and haplotyping of CYP2C19 functional alleles on thin-film biosensor chips.
Pharmacogenetics and genomics 2007;17(2):103-14.
2007: Yazen M Alnouti; Melinda K Shelby; Chuan Chen; Curtis D Klaassen
Influence of phenobarbital on morphine metabolism and disposition: LC-MS/MS determination of morphine (M) and morphine-3-glucuronide (M3G) in Wistar-Kyoto rat serum, bile, and urine.
Current drug metabolism 2007;8(1):79-89.
2007: David B Buckley; Curtis D Klaassen
Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(1):121-7.
2006: Xingguo Cheng; Curtis D Klaassen
Regulation of mRNA expression of xenobiotic transporters by the pregnane x receptor in mouse liver, kidney, and intestine.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(11):1863-7.
2006: Melinda K Shelby; Curtis D Klaassen
Induction of rat UDP-glucuronosyltransferases in liver and duodenum by microsomal enzyme inducers that activate various transcriptional pathways.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(10):1772-8.
2006: Xingguo Cheng; Jonathan Maher; Hong Lu; Curtis D Klaassen
Endocrine regulation of gender-divergent mouse organic anion-transporting polypeptide (Oatp) expression.
Molecular pharmacology 2006;70(4):1291-7.
2006: Yazen Alnouti; Curtis D Klaassen
Tissue distribution and ontogeny of sulfotransferase enzymes in mice.
Toxicological sciences : an official journal of the Society of Toxicology 2006;93(2):242-55.
2006: Jonathan M Maher; Angela L Slitt; T N Callaghan; Xingguo Cheng; C Cheung; F J Gonzalez; Curtis D Klaassen
Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1alpha.
Biochemical pharmacology 2006;72(4):512-22.
2006: Yuji Tanaka; Chuan Chen; Jonathan M Maher; Curtis D Klaassen
Kupffer cell-mediated downregulation of hepatic transporter expression in rat hepatic ischemia-reperfusion.
Transplantation 2006;82(2):258-66.
2006: Supratim Choudhuri; Curtis D Klaassen
Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters.
International journal of toxicology 2006;25(4):231-59.
2006: Angela L Slitt; Nathan J Cherrington; Craig D Fisher; M Negishi; Curtis D Klaassen
Induction of genes for metabolism and transport by trans-stilbene oxide in livers of Sprague-Dawley and Wistar-Kyoto rats.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(7):1190-7.
2006: Jonathan M Maher; Xingguo Cheng; Yuji Tanaka; George L Scheffer; Curtis D Klaassen
Hormonal regulation of renal multidrug resistance-associated proteins 3 and 4 (Mrp3 and Mrp4) in mice.
Biochemical pharmacology 2006;71(10):1470-8.
2006: Jeffrey S Moffit; Lauren M Aleksunes; Jonathan M Maher; George L Scheffer; Curtis D Klaassen; José E Manautou
Induction of hepatic transporters multidrug resistance-associated proteins (Mrp) 3 and 4 by clofibrate is regulated by peroxisome proliferator-activated receptor alpha.
The Journal of pharmacology and experimental therapeutics 2006;317(2):537-45.
2006: Angela L Slitt; Nathan J Cherrington; Matthew Z Dieter; Lauren M Aleksunes; George L Scheffer; W Huang; D D Moore; Curtis D Klaassen
trans-Stilbene oxide induces expression of genes involved in metabolism and transport in mouse liver via CAR and Nrf2 transcription factors.
Molecular pharmacology 2006;69(5):1554-63.
2006: Jonathan M Maher; Nathan J Cherrington; Angela L Slitt; Curtis D Klaassen
Tissue distribution and induction of the rat multidrug resistance-associated proteins 5 and 6.
Life sciences 2006;78(19):2219-25.
2006: Yazen Alnouti; Jay S Petrick; Curtis D Klaassen
Tissue distribution and ontogeny of organic cation transporters in mice.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(3):477-82.
2006: Elaine M Leslie; Jie Liu; Curtis D Klaassen; Michael P Waalkes
Acquired cadmium resistance in metallothionein-I/II(-/-) knockout cells: role of the T-type calcium channel Cacnalpha1G in cadmium uptake.
Molecular pharmacology 2006;69(2):629-39.
2006: Lauren M Aleksunes; Angela L Slitt; Jonathan M Maher; Matthew Z Dieter; Tamara R Knight; Michael Goedken; Nathan J Cherrington; Jefferson Y Chan; Curtis D Klaassen; José E Manautou
Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis.
Cell stress & chaperones 2006;11(4):356-63.
2006: Kaori Nakamoto; Shuang Wang; Robert D Jenison; Grace L Guo; Curtis D Klaassen; Yu-Jui Yvonne Wan; Xiao-bo Zhong
Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene.
BMC genetics 2006;7():29.
2005: Guoli Dai; Nathan Chou; Lin He; Maxwell Afari Gyamfi; Alphonse J Mendy; Angela L Slitt; Curtis D Klaassen; Yu-Jui Yvonne Wan
Retinoid X receptor alpha Regulates the expression of glutathione s-transferase genes and modulates acetaminophen-glutathione conjugation in mouse liver.
Molecular pharmacology 2005;68(6):1590-6.
2005: Chuan Chen; Angela L Slitt; Matthew Z Dieter; Yuji Tanaka; George L Scheffer; Curtis D Klaassen
Up-regulation of Mrp4 expression in kidney of Mrp2-deficient TR- rats.
Biochemical pharmacology 2005;70(7):1088-95.
2005: Xingguo Cheng; Jonathan Maher; Matthew Z Dieter; Curtis D Klaassen
Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(9):1276-82.
2005: Curtis D Klaassen; Angela L Slitt
Regulation of hepatic transporters by xenobiotic receptors.
Current drug metabolism 2005;6(4):309-28.
2005: Xingguo Cheng; Jonathan Maher; Chuan Chen; Curtis D Klaassen
Tissue distribution and ontogeny of mouse organic anion transporting polypeptides (Oatps).
Drug metabolism and disposition: the biological fate of chemicals 2005;33(7):1062-73.
2005: Jonathan M Maher; Xingguo Cheng; Angela L Slitt; Matthew Z Dieter; Curtis D Klaassen
Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(7):956-62.
2005: Jonathan M Maher; Angela L Slitt; Nathan J Cherrington; Xingguo Cheng; Curtis D Klaassen
Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(7):947-55.
2005: Yuji Tanaka; Angela L Slitt; Tyra M Leazer; Jonathan M Maher; Curtis D Klaassen
Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice.
Biochemical and biophysical research communications 2005;326(1):181-7.
2005: Lauren M Aleksunes; Angela M Slitt; Nathan J Cherrington; Michael S Thibodeau; Curtis D Klaassen; José E Manautou
Differential expression of mouse hepatic transporter genes in response to acetaminophen and carbon tetrachloride.
Toxicological sciences : an official journal of the Society of Toxicology 2005;83(1):44-52.
2005: Ning Li; Curtis D Klaassen
Lipopolysaccharide-induced down-regulation of organic anion transporting polypeptide 4 (Oatp4; Slc21a10) is independent of tumor necrosis factor-alpha, Interleukin-1beta, interleukin-6, or inducible nitric oxide synthase.
Toxicological sciences : an official journal of the Society of Toxicology 2005;83(1):197-203.
2004: Matthew Z Dieter; Jonathan M Maher; Xingguo Cheng; Curtis D Klaassen
Expression and regulation of the sterol half-transporter genes ABCG5 and ABCG8 in rats.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2004;139(4):209-18.
2004: Ning Li; Supratim Choudhuri; Nathan J Cherrington; Curtis D Klaassen
Down-regulation of mouse organic anion-transporting polypeptide 4 (Oatp4; Oatp1b2; Slc21a10) mRNA by lipopolysaccharide through the toll-like receptor 4 (TLR4).
Drug metabolism and disposition: the biological fate of chemicals 2004;32(11):1265-71.
2004: Ning Li; Curtis D Klaassen
Role of liver-enriched transcription factors in the down-regulation of organic anion transporting polypeptide 4 (oatp4; oatplb2; slc21a10) by lipopolysaccharide.
Molecular pharmacology 2004;66(3):694-701.
2004: Nichole R Vansell; Jagan R Muppidi; Sultan M Habeebu; Curtis D Klaassen
Promotion of thyroid tumors in rats by pregnenolone-16alpha-carbonitrile (PCN) and polychlorinated biphenyl (PCB).
Toxicological sciences : an official journal of the Society of Toxicology 2004;81(1):50-9.
2004: Doug-Young Ryu; Sung-Ja Lee; Duk Woong Park; Byung Sun Choi; Curtis D Klaassen; Jung-Duck Park
Dietary iron regulates intestinal cadmium absorption through iron transporters in rats.
Toxicology letters 2004;152(1):19-25.
2004: Nathan J Cherrington; Angela L Slitt; Ning Li; Curtis D Klaassen
Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(7):734-41.
2004: Susan C N Buist; Curtis D Klaassen
Rat and mouse differences in gender-predominant expression of organic anion transporter (Oat1-3; Slc22a6-8) mRNA levels.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(6):620-5.
2004: Wilbert H M Heijne; Angela L Slitt; Peter J van Bladeren; John P Groten; Curtis D Klaassen; Rob H Stierum; Ben van Ommen
Bromobenzene-induced hepatotoxicity at the transcriptome level.
Toxicological sciences : an official journal of the Society of Toxicology 2004;79(2):411-22.
2004: Chuan Chen; Curtis D Klaassen
Rat multidrug resistance protein 4 (Mrp4, Abcc4): molecular cloning, organ distribution, postnatal renal expression, and chemical inducibility.
Biochemical and biophysical research communications 2004;317(1):46-53.
2004: Yaxiong Xie; Jie Liu; Yaping Liu; Curtis D Klaassen; Michael P Waalkes
Toxicokinetic and genomic analysis of chronic arsenic exposure in multidrug-resistance mdr1a/1b(-/-) double knockout mice.
Molecular and cellular biochemistry 2004;255(1-2):11-8.
2003: Robert M Grasseschi; Rajanna B Ramaswamy; Deborah Levine; Curtis D Klaassen; Lewis J Wesselius
Cadmium accumulation and detoxification by alveolar macrophages of cigarette smokers.
Chest 2003;124(5):1924-8.
2003: Supratim Choudhuri; Nathan J Cherrington; Ning Li; Curtis D Klaassen
Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(11):1337-45.
2003: Nathan J Cherrington; Angela L Slitt; Jonathan M Maher; Xiao-Xue Zhang; Jun Zhang; Wendong Huang; Yu-Jui Yvonne Wan; David D Moore; Curtis D Klaassen
Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(11):1315-9.
2003: Angela L Slitt; Nathan J Cherrington; Jonathan M Maher; Curtis D Klaassen
Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(9):1176-86.
2003: Chuan Chen; Jeff L Staudinger; Curtis D Klaassen
Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(7):908-15.
2003: Susan C N Buist; Nathan J Cherrington; Curtis D Klaassen
Endocrine regulation of rat organic anion transporters.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(5):559-64.
2003: Alan Hood; Marcia L Allen; YaPing Liu; Jie Liu; Curtis D Klaassen
Induction of T(4) UDP-GT activity, serum thyroid stimulating hormone, and thyroid follicular cell proliferation in mice treated with microsomal enzyme inducers.
Toxicology and applied pharmacology 2003;188(1):6-13.
2003: Melinda K Shelby; Nathan J Cherrington; Nichole R Vansell; Curtis D Klaassen
Tissue mRNA expression of the rat UDP-glucuronosyltransferase gene family.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(3):326-33.
2003: Tyra M Leazer; Curtis D Klaassen
The presence of xenobiotic transporters in rat placenta.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(2):153-67.
2002: Tyra M Leazer; Yaping Liu; Curtis D Klaassen
Cadmium absorption and its relationship to divalent metal transporter-1 in the pregnant rat.
Toxicology and applied pharmacology 2002;185(1):18-24.
2002: David R Johnson; Grace L Guo; Curtis D Klaassen
Expression of rat Multidrug Resistance Protein 2 (Mrp2) in male and female rats during normal and pregnenolone-16alpha-carbonitrile (PCN)-induced postnatal ontogeny.
Toxicology 2002;178(3):209-19.
2002: Jung D Park; Nathan J Cherrington; Curtis D Klaassen
Intestinal absorption of cadmium is associated with divalent metal transporter 1 in rats.
Toxicological sciences : an official journal of the Society of Toxicology 2002;68(2):288-94.
2002: James M Brady; Nathan J Cherrington; Dylan P Hartley; Susan C N Buist; Ning Li; Curtis D Klaassen
Tissue distribution and chemical induction of multiple drug resistance genes in rats.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(7):838-44.
2002: Eric B Harstad; Curtis D Klaassen
iNOS-null mice are not resistant to cadmium chloride-induced hepatotoxicity.
Toxicology 2002;175(1-3):83-90.
2002: Eric B Harstad; Curtis D Klaassen
Analysis of strain difference in sensitivity to cadmium-induced hepatotoxicity in Fischer 344 and Sprague-Dawley rats.
Toxicological sciences : an official journal of the Society of Toxicology 2002;67(2):329-40.
2002: David R Johnson; Curtis D Klaassen
Regulation of rat multidrug resistance protein 2 by classes of prototypical microsomal enzyme inducers that activate distinct transcription pathways.
Toxicological sciences : an official journal of the Society of Toxicology 2002;67(2):182-9.
2002: Eric B Harstad; Curtis D Klaassen
Gadolinium chloride pretreatment prevents cadmium chloride-induced liver damage in both wild-type and MT-null mice.
Toxicology and applied pharmacology 2002;180(3):178-85.
2002: Ning Li; Dylan P Hartley; Nathan J Cherrington; Curtis D Klaassen
Tissue expression, ontogeny, and inducibility of rat organic anion transporting polypeptide 4.
The Journal of pharmacology and experimental therapeutics 2002;301(2):551-60.
2002: Supratim Choudhuri; Kenichiro Ogura; Curtis D Klaassen
Determination of transcription start site and analysis of promoter sequence, splice junction sites, intron sequence and codon usage bias of rat liver-specific organic anion transporter-1 (rlst-1/Oatp-4/Slc21a10) gene.
DNA sequence : the journal of DNA sequencing and mapping 2002;13(2):103-7.
2002: David R Johnson; Curtis D Klaassen
Role of rat multidrug resistance protein 2 in plasma and biliary disposition of dibromosulfophthalein after microsomal enzyme induction.
Toxicology and applied pharmacology 2002;180(1):56-63.
2002: Susan C N Buist; Nathan J Cherrington; Supratim Choudhuri; Dylan P Hartley; Curtis D Klaassen
Gender-specific and developmental influences on the expression of rat organic anion transporters.
The Journal of pharmacology and experimental therapeutics 2002;301(1):145-51.
2002: Grace L Guo; Jeff L Staudinger; Kenichiro Ogura; Curtis D Klaassen
Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha-carbonitrile is via interaction with pregnane X receptor.
Molecular pharmacology 2002;61(4):832-9.
2002: Jie Liu; Maria B Kadiiska; J Christopher Corton; Wei Qu; Michael P Waalkes; Ronald P Mason; Yaping Liu; Curtis D Klaassen
Acute cadmium exposure induces stress-related gene expression in wild-type and metallothionein-I/II-null mice.
Free radical biology & medicine 2002;32(6):525-35.
2002: Eric B Harstad; Curtis D Klaassen
Tumor necrosis factor-alpha-null mice are not resistant to cadmium chloride-induced hepatotoxicity.
Toxicology and applied pharmacology 2002;179(3):155-62.
2002: David R Johnson; Sultan S M Habeebu; Curtis D Klaassen
Increase in bile flow and biliary excretion of glutathione-derived sulfhydryls in rats by drug-metabolizing enzyme inducers is mediated by multidrug resistance protein 2.
Toxicological sciences : an official journal of the Society of Toxicology 2002;66(1):16-26.
2002: Grace L Guo; David R Johnson; Curtis D Klaassen
Postnatal expression and induction by pregnenolone-16alpha-carbonitrile of the organic anion-transporting polypeptide 2 in rat liver.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(3):283-8.
2002: Nichole R Vansell; Curtis D Klaassen
Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(3):240-6.
2002: Jung D Park; Sultan S M Habeebu; Curtis D Klaassen
Testicular toxicity of di-(2-ethylhexyl)phthalate in young Sprague-Dawley rats.
Toxicology 2002;171(2-3):105-15.
2002: Nichole R Vansell; Curtis D Klaassen
Effect of microsomal enzyme inducers on the biliary excretion of triiodothyronine (T(3)) and its metabolites.
Toxicological sciences : an official journal of the Society of Toxicology 2002;65(2):184-91.
2002: Angela L Slitt; Nathan J Cherrington; Dylan P Hartley; Tyra M Leazer; Curtis D Klaassen
Tissue distribution and renal developmental changes in rat organic cation transporter mRNA levels.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(2):212-9.
2002: Jie Liu; Yaping Liu; Douglas A Powell; Michael P Waalkes; Curtis D Klaassen
Multidrug-resistance mdr1a/1b double knockout mice are more sensitive than wild type mice to acute arsenic toxicity, with higher arsenic accumulation in tissues.
Toxicology 2002;170(1-2):55-62.
2002: Curtis D Klaassen
Xenobiotic transporters: another protective mechanism for chemicals.
International journal of toxicology 2002;21(1):7-12.
2002: Grace L Guo; Supratim Choudhuri; Curtis D Klaassen
Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways.
The Journal of pharmacology and experimental therapeutics 2002;300(1):206-12.
2002: Nathan J Cherrington; Dylan P Hartley; Ning Li; David R Johnson; Curtis D Klaassen
Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats.
The Journal of pharmacology and experimental therapeutics 2002;300(1):97-104.
2001: Sultan S M Habeebu; Yaping Liu; Jung D Park; Curtis D Klaassen
Strain differences in the toxicity of cadmium to trigeminal ganglia in mice.
Toxicology and applied pharmacology 2001;177(3):200-7.
2001: Nichole R Vansell; Curtis D Klaassen
Increased biliary excretion of thyroxine by microsomal enzyme inducers.
Toxicology and applied pharmacology 2001;176(3):187-94.
2001: Grace L Guo; Curtis D Klaassen
Protein kinase C suppresses rat organic anion transporting polypeptide 1- and 2-mediated uptake.
The Journal of pharmacology and experimental therapeutics 2001;299(2):551-7.
2001: Jeff L Staudinger; Yaping Liu; Ajay Madan; Sultan S M Habeebu; Curtis D Klaassen
Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(11):1467-72.
2001: Jie Liu; C Corton; D J Dix; Yaping Liu; M P Waalkes; Curtis D Klaassen
Genetic background but not metallothionein phenotype dictates sensitivity to cadmium-induced testicular injury in mice.
Toxicology and applied pharmacology 2001;176(1):1-9.
2001: Yaping Liu; Jie Liu; Curtis D Klaassen
Metallothionein-null and wild-type mice show similar cadmium absorption and tissue distribution following oral cadmium administration.
Toxicology and applied pharmacology 2001;175(3):253-9.
2001: Masufumi Takiguchi; Nathan J Cherrington; Dylan P Hartley; Curtis D Klaassen; Michael P Waalkes
Cyproterone acetate induces a cellular tolerance to cadmium in rat liver epithelial cells involving reduced cadmium accumulation.
Toxicology 2001;165(1):13-25.
2001: Jung D Park; Yaping Liu; Curtis D Klaassen
Protective effect of metallothionein against the toxicity of cadmium and other metals(1).
Toxicology 2001;163(2-3):93-100.
2001: L C Rausch-Derra; Dylan P Hartley; Peter Meier; Curtis D Klaassen
Differential effects of microsomal enzyme-inducing chemicals on the hepatic expression of rat organic anion transporters, OATP1 and OATP2.
Hepatology (Baltimore, Md.) 2001;33(6):1469-78.
2001: Jeff L Staudinger; Bryan Goodwin; Stacey A Jones; D Hawkins-Brown; K I MacKenzie; Anne M Latour; Yaping Liu; Curtis D Klaassen; K K Brown; J Reinhard; Timothy M Willson; Beverly H Koller; Steven A Kliewer
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3369-74.
2001: Kenichiro Ogura; Supratim Choudhuri; Curtis D Klaassen
Genomic organization and tissue-specific expression of splice variants of mouse organic anion transporting polypeptide 2.
Biochemical and biophysical research communications 2001;281(2):431-9.
2001: Supratim Choudhuri; Kenichiro Ogura; Curtis D Klaassen
Cloning, expression, and ontogeny of mouse organic anion-transporting polypeptide-5, a kidney-specific organic anion transporter.
Biochemical and biophysical research communications 2001;280(1):92-8.
2000: Yaping Liu; Jie Liu; S M Habeebu; M P Waalkes; Curtis D Klaassen
Metallothionein-I/II null mice are sensitive to chronic oral cadmium-induced nephrotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2000;57(1):167-76.
2000: S H Jeong; Sultan S M Habeebu; Curtis D Klaassen
Cadmium decreases gap junctional intercellular communication in mouse liver.
Toxicological sciences : an official journal of the Society of Toxicology 2000;57(1):156-66.
2000: Supratim Choudhuri; Kenichiro Ogura; Curtis D Klaassen
Cloning of the full-length coding sequence of rat liver-specific organic anion transporter-1 (rlst-1) and a splice variant and partial characterization of the rat lst-1 gene.
Biochemical and biophysical research communications 2000;274(1):79-86.
2000: Jie Liu; L E Sendelbach; A Parkinson; Curtis D Klaassen
Endotoxin pretreatment protects against the hepatotoxicity of acetaminophen and carbon tetrachloride: role of cytochrome P450 suppression.
Toxicology 2000;147(3):167-76.
2000: Jie Liu; Yaping Liu; S M Habeebu; Michael P Waalkes; Curtis D Klaassen
Chronic combined exposure to cadmium and arsenic exacerbates nephrotoxicity, particularly in metallothionein-I/II null mice.
Toxicology 2000;147(3):157-66.
2000: Sultan S M Habeebu; Jie Liu; Yaping Liu; Curtis D Klaassen
Metallothionein-null mice are more susceptible than wild-type mice to chronic CdCl(2)-induced bone injury.
Toxicological sciences : an official journal of the Society of Toxicology 2000;56(1):211-9.
2000: Kenichiro Ogura; Supratim Choudhuri; Curtis D Klaassen
Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (lst-1).
Biochemical and biophysical research communications 2000;272(2):563-70.
2000: Sultan S M Habeebu; Jie Liu; Yaping Liu; Curtis D Klaassen
Metallothionein-null mice are more sensitive than wild-type mice to liver injury induced by repeated exposure to cadmium.
Toxicological sciences : an official journal of the Society of Toxicology 2000;55(1):223-32.
2000: Alan Hood; Curtis D Klaassen
Differential effects of microsomal enzyme inducers on in vitro thyroxine (T(4)) and triiodothyronine (T(3)) glucuronidation.
Toxicological sciences : an official journal of the Society of Toxicology 2000;55(1):78-84.
2000: Dylan P Hartley; Curtis D Klaassen
Detection of chemical-induced differential expression of rat hepatic cytochrome P450 mRNA transcripts using branched DNA signal amplification technology.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(5):608-16.
2000: JW Boles; Curtis D Klaassen
Effects of molybdate and pentachlorophenol on the sulfation of acetaminophen.
Toxicology 2000;146(1):23-35.
2000: Kolaja Kyle; D T Engelken; Curtis D Klaassen
Inhibition of gap-junctional-intercellular communication in intact rat liver by nongenotoxic hepatocarcinogens.
Toxicology 2000;146(1):15-22.
2000: RT Dunn; Curtis D Klaassen
Thyroid hormone modulation of rat sulphotransferase mRNA expression.
Xenobiotica; the fate of foreign compounds in biological systems 2000;30(4):345-57.
2000: Alan Hood; Curtis D Klaassen
Effects of microsomal enzyme inducers on outer-ring deiodinase activity toward thyroid hormones in various rat tissues.
Toxicology and applied pharmacology 2000;163(3):240-8.
2000: Kolaja Kyle; Jay S Petrick; Curtis D Klaassen
Inhibition of gap-junctional-intercellular communication in thyroid-follicular cells by propylthiouracil and low iodine diet.
Toxicology 2000;143(2):195-202.
1999: Alan Hood; R Hashmi; Curtis D Klaassen
Effects of microsomal enzyme inducers on thyroid-follicular cell proliferation, hyperplasia, and hypertrophy.
Toxicology and applied pharmacology 1999;160(2):163-70.
1999: P Rojas; Curtis D Klaassen
Metallothionein-I and -II knock-out mice are not more sensitive than control mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity.
Neuroscience letters 1999;273(2):113-6.
1999: Jie Liu; Yaping Liu; Sultan S M Habeebu; Curtis D Klaassen
Metallothionein-null mice are highly susceptible to the hematotoxic and immunotoxic effects of chronic CdCl2 exposure.
Toxicology and applied pharmacology 1999;159(2):98-108.
1999: Yaping Liu; Jie Liu; Sultan S M Habeebu; Curtis D Klaassen
Metallothionein protects against the nephrotoxicity produced by chronic CdMT exposure.
Toxicological sciences : an official journal of the Society of Toxicology 1999;50(2):221-7.
1999: Alan Hood; Jie Liu; Curtis D Klaassen
Effects of phenobarbital, pregnenolone-16alpha-carbonitrile, and propylthiouracil on thyroid follicular cell proliferation.
Toxicological sciences : an official journal of the Society of Toxicology 1999;50(1):45-53.
1999: RT Dunn; B A Gleason; Dylan P Hartley; Curtis D Klaassen
Postnatal ontogeny and hormonal regulation of sulfotransferase SULT1B1 in male and female rats.
The Journal of pharmacology and experimental therapeutics 1999;290(1):319-24.
1999: RT Dunn; Kolaja Kyle; Curtis D Klaassen
Effect of partial hepatectomy on the expression of seven rat sulphotransferase mRNAs.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(6):583-93.
1999: Alan Hood; Y P Liu; Vincent H Gattone; Curtis D Klaassen
Sensitivity of thyroid gland growth to thyroid stimulating hormone (TSH) in rats treated with antithyroid drugs.
Toxicological sciences : an official journal of the Society of Toxicology 1999;49(2):263-71.
1999: Kolaja Kyle; Alan Hood; Curtis D Klaassen
The UDP-glucuronyltransferase inducers, phenobarbital and pregnenolone-16alpha-carbonitrile, enhance thyroid-follicular cell apoptosis: association with TGF-beta1 expression.
Toxicology letters 1999;106(2-3):143-50.
1999: JW Boles; Curtis D Klaassen
Effects of molybdate and pentachlorophenol on the sulfation of alpha-naphthol.
Toxicology letters 1999;106(1):1-8.
1999: Jie Liu; Yaping Liu; D Hartley; Curtis D Klaassen; S E Shehin-Johnson; A Lucas; S D Cohen
Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity.
The Journal of pharmacology and experimental therapeutics 1999;289(1):580-6.
1999: Jie Liu; B F Kimler; Yaping Liu; Curtis D Klaassen
Metallothionein-I transgenic mice are not protected from gamma-radiation.
Toxicology letters 1999;104(3):183-7.
1999: Curtis D Klaassen; Jie Liu; Supratim Choudhuri
Metallothionein: an intracellular protein to protect against cadmium toxicity.
Annual review of pharmacology and toxicology 1999;39():267-94.
1998: Jie Liu; Yaping Liu; Sultan S M Habeebu; Curtis D Klaassen
Susceptibility of MT-null mice to chronic CdCl2-induced nephrotoxicity indicates that renal injury is not mediated by the CdMT complex.
Toxicological sciences : an official journal of the Society of Toxicology 1998;46(1):197-203.
1998: Kolaja Kyle; Curtis D Klaassen
Dose-response examination of UDP-glucuronosyltransferase inducers and their ability to increase both TGF-beta expression and thyroid follicular cell apoptosis.
Toxicological sciences : an official journal of the Society of Toxicology 1998;46(1):31-7.
1998: Jie Liu; Sultan S M Habeebu; Yaping Liu; Curtis D Klaassen
Acute CdMT injection is not a good model to study chronic Cd nephropathy: comparison of chronic CdCl2 and CdMT exposure with acute CdMT injection in rats.
Toxicology and applied pharmacology 1998;153(1):48-58.
1998: Curtis D Klaassen; Jie Liu
Metallothionein transgenic and knock-out mouse models in the study of cadmium toxicity.
The Journal of toxicological sciences 1998;23 Suppl 2():97-102.
1998: JW Boles; Curtis D Klaassen
Effects of molybdate and pentachlorophenol on the sulfation of dehydroepiandrosterone.
Toxicology and applied pharmacology 1998;151(1):105-9.
1998: RT Dunn; Curtis D Klaassen
Tissue-specific expression of rat sulfotransferase messenger RNAs.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(6):598-604.
1998: JW Boles; Curtis D Klaassen
Effects of molybdate on the sulfation of harmol and alpha-naphthol.
Toxicology 1998;127(1-3):121-7.
1998: Sultan S M Habeebu; Jie Liu; Curtis D Klaassen
Cadmium-induced apoptosis in mouse liver.
Toxicology and applied pharmacology 1998;149(2):203-9.
1998: Jie Liu; Yaping Liu; Sultan S M Habeebu; Curtis D Klaassen
Metallothionein (MT)-null mice are sensitive to cisplatin-induced hepatotoxicity.
Toxicology and applied pharmacology 1998;149(1):24-31.
1998: Curtis D Klaassen; L Liu; RT Dunn
Regulation of sulfotransferase mRNA expression in male and female rats of various ages.
Chemico-biological interactions 1998;109(1-3):299-313.
1998: Curtis D Klaassen; Jie Liu
Induction of metallothionein as an adaptive mechanism affecting the magnitude and progression of toxicological injury.
Environmental health perspectives 1998;106 Suppl 1():297-300.
1997: Curtis D Klaassen; JW Boles
Sulfation and sulfotransferases 5: the importance of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) in the regulation of sulfation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997;11(6):404-18.
1997: Curtis D Klaassen; Jie Liu
Role of metallothionein in cadmium-induced hepatotoxicity and nephrotoxicity.
Drug metabolism reviews 1997;29(1-2):79-102.
1996: Zoltán Gregus; T Fekete; E Halászi; Curtis D Klaassen
Does hepatic ATP depletion impair glycine conjugation in vivo?
Drug metabolism and disposition: the biological fate of chemicals 1996;24(12):1347-54.
1996: L Liu; Edward LeCluyse; Jie Liu; Curtis D Klaassen
Sulfotransferase gene expression in primary cultures of rat hepatocytes.
Biochemical pharmacology 1996;52(10):1621-30.
1996: K K Kramer; J T Zoelle; Curtis D Klaassen
Induction of metallothionein mRNA and protein in primary murine neuron cultures.
Toxicology and applied pharmacology 1996;141(1):1-7.
1996: H Zheng; Jie Liu; Yaping Liu; Curtis D Klaassen
Hepatocytes from metallothionein-I and II knock-out mice are sensitive to cadmium- and tert-butylhydroperoxide-induced cytotoxicity.
Toxicology letters 1996;87(2-3):139-45.
1996: L Liu; Curtis D Klaassen
Ontogeny and hormonal basis of female-dominant rat hepatic sulfotransferases.
The Journal of pharmacology and experimental therapeutics 1996;279(1):386-91.
1996: L Liu; Curtis D Klaassen
Ontogeny and hormonal basis of male-dominant rat hepatic sulfotransferases.
Molecular pharmacology 1996;50(3):565-72.
1996: L Liu; Curtis D Klaassen
Regulation of hepatic sulfotransferases by steroidal chemicals in rats.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(8):854-8.
1996: L Liu; Curtis D Klaassen
Different mechanism of saturation of acetaminophen sulfate conjugation in mice and rats.
Toxicology and applied pharmacology 1996;139(1):128-34.
1996: Zoltán Gregus; T Fekete; E Halászi; Curtis D Klaassen
Lipoic acid impairs glycine conjugation of benzoic acid and renal excretion of benzoylglycine.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(6):682-8.
1996: Y P Liu; Jie Liu; R D Palmiter; Curtis D Klaassen
Metallothionein-I-transgenic mice are not protected from acute cadmium-metallothionein-induced nephrotoxicity.
Toxicology and applied pharmacology 1996;137(2):307-15.
1996: Jie Liu; Yaping Liu; A E Michalska; K H Andy Choo; Curtis D Klaassen
Metallothionein plays less of a protective role in cadmium-metallothionein-induced nephrotoxicity than in cadmium chloride-induced hepatotoxicity.
The Journal of pharmacology and experimental therapeutics 1996;276(3):1216-23.
1996: S Choudhuri; W L Liu; Nancy E J Berman; Curtis D Klaassen
Cadmium accumulation and metallothionein expression in brain of mice at different stages of development.
Toxicology letters 1996;84(3):127-33.
1996: Jie Liu; Curtis D Klaassen
Absorption and distribution of cadmium in metallothionein-I transgenic mice.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1996;29(2):294-300.
1996: T Oguro; C Madhu; Jie Liu; Curtis D Klaassen
Molybdate impairs glycosaminoglycan sulfation in rat cartilage.
Toxicology and applied pharmacology 1996;136(2):354-60.
1996: Jie Liu; Yaping Liu; A E Michalska; K H Andy Choo; Curtis D Klaassen
Distribution and retention of cadmium in metallothionein I and II null mice.
Toxicology and applied pharmacology 1996;136(2):260-8.
1996: H Zheng; Jie Liu; K H Andy Choo; A E Michalska; Curtis D Klaassen
Metallothionein-I and -II knock-out mice are sensitive to cadmium-induced liver mRNA expression of c-jun and p53.
Toxicology and applied pharmacology 1996;136(2):229-35.
1996: K K Kramer; Jie Liu; S Choudhuri; Curtis D Klaassen
Induction of metallothionein mRNA and protein in murine astrocyte cultures.
Toxicology and applied pharmacology 1996;136(1):94-100.
1995: C Madhu; Zoltán Gregus; Curtis D Klaassen
Simple method for analysis of diquat in biological fluids and tissues by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical applications 1995;674(2):193-6.
1995: M B Iszard; Jie Liu; Curtis D Klaassen
Effect of several metallothionein inducers on oxidative stress defense mechanisms in rats.
Toxicology 1995;104(1-3):25-33.
1995: T N Thompson; Curtis D Klaassen
The effects of hepatic microsomal enzyme inducers on the pharmacokinetics of ouabain after portal and systemic administration to rats.
The Journal of pharmacy and pharmacology 1995;47(12A):1041-7.
1995: Yaping Liu; Jie Liu; M B Iszard; Glen K Andrews; R D Palmiter; Curtis D Klaassen
Transgenic mice that overexpress metallothionein-I are protected from cadmium lethality and hepatotoxicity.
Toxicology and applied pharmacology 1995;135(2):222-8.
1995: H J Kim; P Rozman; Curtis D Klaassen
Acetaminophen does not decrease hepatic 3'-phosphoadenosine 5'-phosphosulfate in mice.
The Journal of pharmacology and experimental therapeutics 1995;275(3):1506-11.
1995: Jie Liu; Yaping Liu; Andrew Parkinson; Curtis D Klaassen
Effect of oleanolic acid on hepatic toxicant-activating and detoxifying systems in mice.
The Journal of pharmacology and experimental therapeutics 1995;275(2):768-74.
1995: H J Kim; J H Cho; Curtis D Klaassen
Depletion of hepatic 3'-phosphoadenosine 5'-phosphosulfate (PAPS) and sulfate in rats by xenobiotics that are sulfated.
The Journal of pharmacology and experimental therapeutics 1995;275(2):654-8.
1995: Jie Liu; Yaping Liu; P Bullock; Curtis D Klaassen
Suppression of liver cytochrome P450 by alpha-hederin: relevance to hepatoprotection.
Toxicology and applied pharmacology 1995;134(1):124-31.
1995: M B Iszard; Jie Liu; Yaping Liu; Timothy P Dalton; Glen K Andrews; R D Palmiter; Curtis D Klaassen
Characterization of metallothionein-I-transgenic mice.
Toxicology and applied pharmacology 1995;133(2):305-12.
1995: H J Kim; C Madhu; J H Cho; Curtis D Klaassen
In vivo modification of 3'-phosphoadenosine 5'-phosphosulfate and sulfate by infusion of sodium sulfate, cysteine, and methionine.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(8):840-5.
1995: H Zheng; Nancy E J Berman; Curtis D Klaassen
Chemical modulation of metallothionein I and III mRNA in mouse brain.
Neurochemistry international 1995;27(1):43-58.
1995: Catherine Dorian; Curtis D Klaassen
Protection by zinc-metallothionein (ZnMT) against cadmium-metallothionein-induced nephrotoxicity.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1995;26(1):99-106.
1995: Jie Liu; Yaping Liu; R A Barter; Curtis D Klaassen
Alteration of thyroid homeostasis by UDP-glucuronosyltransferase inducers in rats: a dose-response study.
The Journal of pharmacology and experimental therapeutics 1995;273(2):977-85.
1995: S Choudhuri; K K Kramer; Nancy E J Berman; Timothy P Dalton; Glen K Andrews; Curtis D Klaassen
Constitutive expression of metallothionein genes in mouse brain.
Toxicology and applied pharmacology 1995;131(1):144-54.
1995: Jie Liu; Yaping Liu; Curtis D Klaassen
Protective effect of oleanolic acid against chemical-induced acute necrotic liver injury in mice.
Zhongguo yao li xue bao = Acta pharmacologica Sinica 1995;16(2):97-102.
1995: Catherine Dorian; Vincent H Gattone; Curtis D Klaassen
Discrepancy between the nephrotoxic potencies of cadmium-metallothionein and cadmium chloride and the renal concentration of cadmium in the proximal convoluted tubules.
Toxicology and applied pharmacology 1995;130(1):161-8.
1994: R B Henry; Jie Liu; S Choudhuri; Curtis D Klaassen
Species variation in hepatic metallothionein.
Toxicology letters 1994;74(1):23-33.
1994: Jie Liu; Yaping Liu; Curtis D Klaassen
Nephrotoxicity of CdCl2 and Cd-metallothionein in cultured rat kidney proximal tubules and LLC-PK1 cells.
Toxicology and applied pharmacology 1994;128(2):264-70.
1994: R A Barter; Curtis D Klaassen
Reduction of thyroid hormone levels and alteration of thyroid function by four representative UDP-glucuronosyltransferase inducers in rats.
Toxicology and applied pharmacology 1994;128(1):9-17.
1994: T Oguro; Zoltán Gregus; C Madhu; L Liu; Curtis D Klaassen
Molybdate depletes hepatic 3-phosphoadenosine 5-phosphosulfate and impairs the sulfation of acetaminophen in rats.
The Journal of pharmacology and experimental therapeutics 1994;270(3):1145-51.
1994: Curtis D Klaassen; S Choudhuri; James M McKim; L D Lehman-McKeeman; W C Kershaw
In vitro and in vivo studies on the degradation of metallothionein.
Environmental health perspectives 1994;102 Suppl 3():141-6.
1994: Zoltán Gregus; H J Kim; C Madhu; Y Liu; P Rozman; Curtis D Klaassen
Sulfation of acetaminophen and acetaminophen-induced alterations in sulfate and 3'-phosphoadenosine 5'-phosphosulfate homeostasis in rats with deficient dietary intake of sulfur.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(5):725-30.
1994: H Kreppel; Jie Liu; Yaping Liu; Franz-Xaver Reichl; Curtis D Klaassen
Zinc-induced arsenite tolerance in mice.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1994;23(1):32-7.
1994: Zoltán Gregus; T Oguro; Curtis D Klaassen
Nutritionally and chemically induced impairment of sulfate activation and sulfation of xenobiotics in vivo.
Chemico-biological interactions 1994;92(1-3):169-77.
1994: Jie Liu; Yaping Liu; Curtis D Klaassen
The effect of Chinese hepatoprotective medicines on experimental liver injury in mice.
Journal of ethnopharmacology 1994;42(3):183-91.
1994: S Choudhuri; James M McKim; Curtis D Klaassen
Induction of metallothionein by superantigenic bacterial exotoxin: probable involvement of the immune system.
Biochimica et biophysica acta 1994;1225(2):171-9.
1994: Jie Liu; Yaping Liu; Q Mao; Curtis D Klaassen
The effects of 10 triterpenoid compounds on experimental liver injury in mice.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1994;22(1):34-40.
1993: Zoltán Gregus; T Fekete; F Varga; Curtis D Klaassen
Effect of valproic acid on glycine conjugation of benzoic acid.
The Journal of pharmacology and experimental therapeutics 1993;267(3):1068-75.
1993: Jie Liu; Yaping Liu; C Madhu; Curtis D Klaassen
Protective effects of oleanolic acid on acetaminophen-induced hepatotoxicity in mice.
The Journal of pharmacology and experimental therapeutics 1993;266(3):1607-13.
1993: J W Bauman; Jie Liu; Curtis D Klaassen
Production of metallothionein and heat-shock proteins in response to metals.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1993;21(1):15-22.
1993: Jie Liu; S Choudhuri; Yaping Liu; H Kreppel; Glen K Andrews; Curtis D Klaassen
Induction of metallothionein by alpha-hederin.
Toxicology and applied pharmacology 1993;121(1):144-51.
1993: Yaping Liu; H Kreppel; Jie Liu; S Choudhuri; Curtis D Klaassen
Oleanolic acid protects against cadmium hepatotoxicity by inducing metallothionein.
The Journal of pharmacology and experimental therapeutics 1993;266(1):400-6.
1993: S Choudhuri; James M McKim; Curtis D Klaassen
Differential expression of the metallothionein gene in liver and brain of mice and rats.
Toxicology and applied pharmacology 1993;119(1):1-10.
1993: C Madhu; D Y Mitchell; Curtis D Klaassen
Effect of P-450 inducers on biliary excretion of glutathione and its hydrolysis products. Correlation between hepatic gamma-glutamyltranspeptidase activity and the proportion of glutathione hydrolysis products in bile.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(2):342-9.
1993: Zoltán Gregus; T Fekete; F Varga; Curtis D Klaassen
Dependence of glycine conjugation on availability of glycine: role of the glycine cleavage system.
Xenobiotica; the fate of foreign compounds in biological systems 1993;23(2):141-53.
1993: James M McKim; J M McKim; S Naumann; D E Hammermeister; A D Hoffman; Curtis D Klaassen
In vivo microdialysis sampling of phenol and phenyl glucuronide in the blood of unanesthetized rainbow trout: implications for toxicokinetic studies.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1993;20(2):190-8.
1993: H Kreppel; J W Bauman; Jie Liu; James M McKim; Curtis D Klaassen
Induction of metallothionein by arsenicals in mice.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1993;20(2):184-9.
1992: Catherine Dorian; Vincent H Gattone; Curtis D Klaassen
Accumulation and degradation of the protein moiety of cadmium-metallothionein (CdMT) in the mouse kidney.
Toxicology and applied pharmacology 1992;117(2):242-8.
1992: J W Bauman; C Madhu; James M McKim; Yaping Liu; Curtis D Klaassen
Induction of hepatic metallothionein by paraquat.
Toxicology and applied pharmacology 1992;117(2):233-41.
1992: J W Bauman; Y P Liu; Glen K Andrews; Curtis D Klaassen
Examination of potential mechanism(s) of metallothionein induction by diethyl maleate.
Toxicology and applied pharmacology 1992;117(2):226-32.
1992: C Madhu; Zoltán Gregus; Curtis D Klaassen
Marked interanimal differences in susceptibility of Sprague-Dawley rats to diquat-induced oxidative stress in the liver: correlation with hepatic uptake of diquat.
The Journal of pharmacology and experimental therapeutics 1992;263(3):1003-8.
1992: Jie Liu; W C Kershaw; Y P Liu; Curtis D Klaassen
Cadmium-induced hepatic endothelial cell injury in inbred strains of mice.
Toxicology 1992;75(1):51-62.
1992: James M McKim; S Choudhuri; Curtis D Klaassen
In vitro degradation of apo-, zinc-, and cadmium-metallothionein by cathepsins B, C, and D.
Toxicology and applied pharmacology 1992;116(1):117-24.
1992: C Madhu; Zoltán Gregus; C C Cheng; Curtis D Klaassen
Identification of the mixed disulfide of glutathione and cysteinylglycine in bile: dependence on gamma-glutamyl transferase and responsiveness to oxidative stress.
The Journal of pharmacology and experimental therapeutics 1992;262(3):896-900.
1992: R A Barter; Curtis D Klaassen
Rat liver microsomal UDP-glucuronosyltransferase activity toward thyroxine: characterization, induction, and form specificity.
Toxicology and applied pharmacology 1992;115(2):261-7.
1992: C Madhu; T Maziasz; Curtis D Klaassen
Effect of pregnenolone-16 alpha-carbonitrile and dexamethasone on acetaminophen-induced hepatotoxicity in mice.
Toxicology and applied pharmacology 1992;115(2):191-8.
1992: D Goon; Curtis D Klaassen
Effects of microsomal enzyme inducers upon UDP-glucuronic acid concentration and UDP-glucuronosyltransferase activity in the rat intestine and liver.
Toxicology and applied pharmacology 1992;115(2):253-60.
1992: S Choudhuri; James M McKim; Curtis D Klaassen
Role of hepatic lysosomes in the degradation of metallothionein.
Toxicology and applied pharmacology 1992;115(1):64-71.
1992: J W Bauman; James M McKim; Jie Liu; Curtis D Klaassen
Induction of metallothionein by diethyl maleate.
Toxicology and applied pharmacology 1992;114(2):188-96.
1992: H J Kim; P Rozman; C Madhu; Curtis D Klaassen
Homeostasis of sulfate and 3'-phosphoadenosine 5'-phosphosulfate in rats after acetaminophen administration.
The Journal of pharmacology and experimental therapeutics 1992;261(3):1015-21.
1992: Jie Liu; James M McKim; Y P Liu; Curtis D Klaassen
Effects of butyrate homologues on metallothionein induction in rat primary hepatocyte cultures.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1992;28A(5):320-6.
1992: Zoltán Gregus; A F Stein; F Varga; Curtis D Klaassen
Effect of lipoic acid on biliary excretion of glutathione and metals.
Toxicology and applied pharmacology 1992;114(1):88-96.
1992: Y P Liu; Jie Liu; X S Jia; Q Mao; Curtis D Klaassen
Protective effects of fulvotomentosides on cadmium-induced hepatotoxicity.
Zhongguo yao li xue bao = Acta pharmacologica Sinica 1992;13(3):213-7.
1992: Y P Liu; Jie Liu; X S Jia; Q Mao; C Madhu; Curtis D Klaassen
Protective effects of fulvotomentosides on acetaminophen-induced hepatotoxicity.
Zhongguo yao li xue bao = Acta pharmacologica Sinica 1992;13(3):209-12.
1992: P Rozman; H J Kim; C Madhu; Zoltán Gregus; Curtis D Klaassen
Homeostasis of sulfate and 3'-phosphoadenosine 5'-phosphosulfate in rats with deficient dietary intake of sulfur.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(3):374-8.
1992: C Madhu; Curtis D Klaassen
Bromobenzene-glutathione excretion into bile reflects toxic activation of bromobenzene in rats.
Toxicology letters 1992;60(2):227-36.
1992: R A Barter; Curtis D Klaassen
UDP-glucuronosyltransferase inducers reduce thyroid hormone levels in rats by an extrathyroidal mechanism.
Toxicology and applied pharmacology 1992;113(1):36-42.
1992: Zoltán Gregus; T Fekete; F Varga; Curtis D Klaassen
Availability of glycine and coenzyme A limits glycine conjugation in vivo.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(2):234-40.
1992: P Rozman; H J Kim; C Madhu; Curtis D Klaassen
Tissue sulfate determination by ion chromatography.
Journal of chromatography 1992;574(1):146-9.
1992: L E Sendelbach; W C Kershaw; F Cuppage; Curtis D Klaassen
Cd-metallothionein nephrotoxicity in inbred strains of mice.
Journal of toxicology and environmental health 1992;35(2):115-26.
1992: James M McKim; Jie Liu; Y P Liu; Curtis D Klaassen
Distribution of cadmium chloride and cadmium-metallothionein to liver parenchymal, Kupffer, and endothelial cells: their relative ability to express metallothionein.
Toxicology and applied pharmacology 1992;112(2):324-30.
1992: James M McKim; Jie Liu; Y P Liu; Curtis D Klaassen
Induction of metallothionein by cadmium-metallothionein in rat liver: a proposed mechanism.
Toxicology and applied pharmacology 1992;112(2):318-23.
1992: W C Kershaw; Curtis D Klaassen
Degradation and metal composition of hepatic isometallothioneins in rats.
Toxicology and applied pharmacology 1992;112(1):24-31.
1992: Jie Liu; W C Kershaw; Curtis D Klaassen
Protective effects of zinc on cultured rat primary hepatocytes to metals with low affinity for metallothionein.
Journal of toxicology and environmental health 1992;35(1):51-62.
1991: T J Maziasz; Jie Liu; C Madhu; Curtis D Klaassen
The differential effects of hepatotoxicants on the sulfation pathway in rats.
Toxicology and applied pharmacology 1991;110(3):365-73.
1991: J W Bauman; Jie Liu; Y P Liu; Curtis D Klaassen
Increase in metallothionein produced by chemicals that induce oxidative stress.
Toxicology and applied pharmacology 1991;110(2):347-54.
1991: C Madhu; Curtis D Klaassen
Protective effect of pregnenolone-16 alpha-carbonitrile on acetaminophen-induced hepatotoxicity in hamsters.
Toxicology and applied pharmacology 1991;109(2):305-13.
1991: S R Howell; Curtis D Klaassen
Circadian variation of hepatic UDP-glucuronic acid and the glucuronidation of xenobiotics in mice.
Toxicology letters 1991;57(1):73-9.
1991: D Goon; Curtis D Klaassen
Intestinal biotransformation of harmol and 1-naphthol in the rat. Further evidence of dose-dependent phase-II conjugation in situ.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(2):340-7.
1991: W C Kershaw; Curtis D Klaassen
Cadmium-induced elevation of hepatic isometallothionein concentrations in inbred strains of mice.
Chemico-biological interactions 1991;78(3):269-82.
1991: Jie Liu; W C Kershaw; Curtis D Klaassen
The protective effect of metallothionein on the toxicity of various metals in rat primary hepatocyte culture.
Toxicology and applied pharmacology 1991;107(1):27-34.
1990: W C Kershaw; T Iga; Curtis D Klaassen
Ethanol decreases cadmium hepatotoxicity in rats: possible role of hepatic metallothionein induction.
Toxicology and applied pharmacology 1990;106(3):448-55.
1990: W C Kershaw; L D Lehman-McKeeman; Curtis D Klaassen
Hepatic isometallothioneins in mice: induction in adults and postnatal ontogeny.
Toxicology and applied pharmacology 1990;104(2):267-75.
1990: L E Sendelbach; C A White; S Howell; Zoltán Gregus; Curtis D Klaassen
Effect of sulfhydryl-deficient diets on hepatic metallothionein, glutathione, and adenosine 3'-phosphate 5'-phosphosulfate (PAPS) levels in rats.
Toxicology and applied pharmacology 1990;102(2):259-67.
1990: Jie Liu; W C Kershaw; Curtis D Klaassen
Rat primary hepatocyte cultures are a good model for examining metallothionein-induced tolerance to cadmium toxicity.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1990;26(1):75-9.
1990: D Goon; Curtis D Klaassen
Dose-dependent intestinal glucuronidation and sulfation of acetaminophen in the rat in situ.
The Journal of pharmacology and experimental therapeutics 1990;252(1):201-7.
1990: Zoltán Gregus; C Madhu; Curtis D Klaassen
Effect of microsomal enzyme inducers on biliary and urinary excretion of acetaminophen metabolites in rats. Decreased hepatobiliary and increased hepatovascular transport of acetaminophen-glucuronide after microsomal enzyme induction.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(1):10-9.
1989: D Goon; Curtis D Klaassen
Dosage-dependent absorption of cadmium in the rat intestine measured in situ.
Toxicology and applied pharmacology 1989;100(1):41-50.
1989: Curtis D Klaassen; L D Lehman-McKeeman
Regulation of the isoforms of metallothionein.
Biological trace element research 1989;21():119-29.
1989: L E Sendelbach; W M Bracken; Curtis D Klaassen
Comparisons of the toxicity of CdCl2 and Cd-metallothionein in isolated rat hepatocytes.
Toxicology 1989;55(1-2):83-91.
1989: C Madhu; Zoltán Gregus; Curtis D Klaassen
Biliary excretion of acetaminophen-glutathione as an index of toxic activation of acetaminophen: effect of chemicals that alter acetaminophen hepatotoxicity.
The Journal of pharmacology and experimental therapeutics 1989;248(3):1069-77.
1989: Zoltán Gregus; C Madhu; Curtis D Klaassen
Inducibility of glutathione S-transferases in hamsters.
Cancer letters 1989;44(2):89-94.
1988: Zoltán Gregus; C White; S Howell; Curtis D Klaassen
Effect of glutathione depletion on sulfate activation and sulfate ester formation in rats.
Biochemical pharmacology 1988;37(22):4307-12.
1988: Zoltán Gregus; C Madhu; D Goon; Curtis D Klaassen
Effect of galactosamine-induced hepatic UDP-glucuronic acid depletion on acetaminophen elimination in rats. Dispositional differences between hepatically and extrahepatically formed glucuronides of acetaminophen and other chemicals.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(4):527-33.
1988: A F Stein; Zoltán Gregus; Curtis D Klaassen
Species variations in biliary excretion of glutathione-related thiols and methylmercury.
Toxicology and applied pharmacology 1988;93(3):351-9.
1988: S R Howell; L A Kotkoskie; R L Dills; Curtis D Klaassen
3-Hydroxylation of salicylamide in mice.
Journal of pharmaceutical sciences 1988;77(4):309-13.
1988: Zoltán Gregus; Curtis D Klaassen
Effect of butylated hydroxyanisole on hepatic glucuronidation and biliary excretion of drugs in mice.
The Journal of pharmacy and pharmacology 1988;40(4):237-42.
1988: L D Lehman-McKeeman; Glen K Andrews; Curtis D Klaassen
Induction of hepatic metallothioneins determined at isoprotein and messenger RNA levels in glucocorticoid-treated rats.
The Biochemical journal 1988;249(2):429-33.
1988: T Maitani; F E Cuppage; Curtis D Klaassen
Nephrotoxicity of intravenously injected cadmium-metallothionein: critical concentration and tolerance.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1988;10(1):98-108.
1988: L E Sendelbach; Curtis D Klaassen
Kidney synthesizes less metallothionein than liver in response to cadmium chloride and cadmium-metallothionein.
Toxicology and applied pharmacology 1988;92(1):95-102.
1988: L D Lehman-McKeeman; Glen K Andrews; Curtis D Klaassen
Ontogeny and induction of hepatic isometallothioneins in immature rats.
Toxicology and applied pharmacology 1988;92(1):10-7.
1988: L D Lehman-McKeeman; Glen K Andrews; Curtis D Klaassen
Mechanisms of regulation of rat hepatic metallothionein-I and metallothionein-II levels following administration of zinc.
Toxicology and applied pharmacology 1988;92(1):1-9.
1988: Zoltán Gregus; C Madhu; Curtis D Klaassen
Species variation in toxication and detoxication of acetaminophen in vivo: a comparative study of biliary and urinary excretion of acetaminophen metabolites.
The Journal of pharmacology and experimental therapeutics 1988;244(1):91-9.
1988: G A Hazelton; Curtis D Klaassen
UDP-glucuronosyltransferase activity toward digitoxigenin-monodigitoxoside. Differences in activation and induction properties in rat and mouse liver.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(1):30-6.
1987: M P Arlotto; A J Sonderfan; Curtis D Klaassen; Andrew Parkinson
Studies on the pregnenolone-16 alpha-carbonitrile-inducible form of rat liver microsomal cytochrome P-450 and UDP-glucuronosyltransferase.
Biochemical pharmacology 1987;36(22):3859-66.
1987: Zoltán Gregus; A F Stein; Curtis D Klaassen
Effect of inhibition of gamma-glutamyltranspeptidase on biliary and urinary excretion of glutathione-derived thiols and methylmercury.
The Journal of pharmacology and experimental therapeutics 1987;242(1):27-32.
1987: Zoltán Gregus; A F Stein; Curtis D Klaassen
Age-dependent biliary excretion of glutathione-related thiols in rats: role of gamma-glutamyltransferase.
The American journal of physiology 1987;253(1 Pt 1):G86-92.
1987: R L Dills; S R Howell; Curtis D Klaassen
Hepatic UDP-glucose and UDP-glucuronic acid synthesis rates in rats during a reduced energy state.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(3):281-8.
1987: W M Bracken; Curtis D Klaassen
Induction of metallothionein in rat primary hepatocyte cultures: evidence for direct and indirect induction.
Journal of toxicology and environmental health 1987;22(2):163-74.
1987: Curtis D Klaassen; M P Waalkes
Cadmium-binding proteins in rat testes: characterization and apparent source of the low-molecular-weight protein.
Experientia. Supplementum 1987;52():273-80.