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Ronald Klabe

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Chemicals & Drugs

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Publications

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Brent Douty; Brian Wayland; Paul J Ala; Michael J Bower; James Pruitt; Lori Bostrom; Min Wei; Ronald Klabe; Lucie Gonneville; Richard Wynn; Timothy C Burn; Phillip C C Liu; Andrew P Combs; Eddy W Yue
Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines.
Min Wei; Richard Wynn; Gregory F Hollis; Boshan Liao; Alexander Margulis; Brian G Reid; Ronald Klabe; Phillip C C Liu; Mary Becker-Pasha; Mark J Rupar; Timothy C Burn; Dale E McCall; Yanlong Li
High-throughput determination of mode of inhibition in lead identification and optimization.
Paul J Ala; Lucie Gonneville; Milton C Hillman; Mary Becker-Pasha; Min Wei; Brian G Reid; Ronald Klabe; Eddy W Yue; Brian Wayland; Brent Douty; Padmaja Polam; Zelda R Wasserman; Michael Bower; Andrew P Combs; Timothy C Burn; Gregory F Hollis; Richard Wynn
Structural basis for inhibition of protein-tyrosine phosphatase 1B by isothiazolidinone heterocyclic phosphonate mimetics.

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All Publications

2008: Brent Douty; Brian Wayland; Paul J Ala; Michael J Bower; James Pruitt; Lori Bostrom; Min Wei; Ronald Klabe; Lucie Gonneville; Richard Wynn; Timothy C Burn; Phillip C C Liu; Andrew P Combs; Eddy W Yue
Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines.
Bioorganic & medicinal chemistry letters 2008;18(1):66-71.
2007: Min Wei; Richard Wynn; Gregory F Hollis; Boshan Liao; Alexander Margulis; Brian G Reid; Ronald Klabe; Phillip C C Liu; Mary Becker-Pasha; Mark J Rupar; Timothy C Burn; Dale E McCall; Yanlong Li
High-throughput determination of mode of inhibition in lead identification and optimization.
Journal of biomolecular screening 2007;12(2):220-8.
2006: Paul J Ala; Lucie Gonneville; Milton C Hillman; Mary Becker-Pasha; Min Wei; Brian G Reid; Ronald Klabe; Eddy W Yue; Brian Wayland; Brent Douty; Padmaja Polam; Zelda R Wasserman; Michael Bower; Andrew P Combs; Timothy C Burn; Gregory F Hollis; Richard Wynn
Structural basis for inhibition of protein-tyrosine phosphatase 1B by isothiazolidinone heterocyclic phosphonate mimetics.
The Journal of biological chemistry 2006;281(43):32784-95.
2003: Robert F Kaltenbach; Mona Patel; Robert E Waltermire; Gregory D Harris; Benjamin R P Stone; Ronald Klabe; Sena Garber; Lee Bacheler; Beverly C Cordova; Kelly Logue; Matthew R Wright; Susan Erickson-Viitanen; George L Trainor
Synthesis, antiviral activity and pharmacokinetics of P1/P1' substituted 3-aminoindazole cyclic urea HIV protease inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(4):605-8.
2003: Susan Erickson-Viitanen; Jing-Tao Wu; Guoen Shi; Steven Unger; Robert W King; Barbara Fish; Ronald Klabe; Romas Geleziunas; Karen Gallagher; Michael J Otto; Ray F Schinazi
Cellular pharmacology of D-d4FC, a nucleoside analogue active against drug-resistant HIV.
Antiviral chemistry & chemotherapy 2003;14(1):39-47.
2002: Robert W King; Ronald Klabe; Carol D Reid; Susan Erickson-Viitanen
Potency of nonnucleoside reverse transcriptase inhibitors (NNRTIs) used in combination with other human immunodeficiency virus NNRTIs, NRTIs, or protease inhibitors.
Antimicrobial agents and chemotherapy 2002;46(6):1640-6.
2002: Ray F Schinazi; John Mellors; Holly Bazmi; Sharon Diamond; Sena Garber; Karen Gallagher; Romas Geleziunas; Ronald Klabe; James Michael Pierce; Marlene Rayner; Jing-Tao Wu; Hangchun Zhang; Jennifer Hammond; Lee Bacheler; Douglas J Manion; Michael J Otto; Lieven Stuyver; George L Trainor; Dennis C Liotta; Susan Erickson-Viitanen
DPC 817: a cytidine nucleoside analog with activity against zidovudine- and lamivudine-resistant viral variants.
Antimicrobial agents and chemotherapy 2002;46(5):1394-401.
2001: Chien-An Chen; Scott McN Sieburth; Athanasios Glekas; G W Hewitt; George L Trainor; Susan Erickson-Viitanen; Sena Garber; Beverly C Cordova; S Jeffry; Ronald Klabe
Drug design with a new transition state analog of the hydrated carbonyl: silicon-based inhibitors of the HIV protease.
Chemistry & biology 2001;8(12):1161-6.
2001: Robert F Kaltenbach; George L Trainor; D Getman; G Harris; Sena Garber; Beverly C Cordova; Lee Bacheler; S Jeffrey; Kelly Logue; P Cawood; Ronald Klabe; Sharon Diamond; M Davies; JA Saye; J Jona; Susan Erickson-Viitanen
DPC 681 and DPC 684: potent, selective inhibitors of human immunodeficiency virus protease active against clinically relevant mutant variants.
Antimicrobial agents and chemotherapy 2001;45(11):3021-8.
2001: Mona Patel; RJ McHugh; Beverly C Cordova; Ronald Klabe; Lee Bacheler; Susan Erickson-Viitanen; James D Rodgers
Synthesis and evaluation of novel quinolinones as HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(14):1943-5.
2001: AJ Cocuzza; DR Chidester; Beverly C Cordova; Ronald Klabe; S Jeffrey; Sharon Diamond; C A Weigelt; Soo S Ko; Lee Bacheler; Susan Erickson-Viitanen; James D Rodgers
4,1-Benzoxazepinone analogues of efavirenz (Sustiva) as HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(11):1389-92.
2001: Jay A Markwalder; David D Christ; Abdul E Mutlib; Beverly C Cordova; Ronald Klabe; Steven P Seitz
Synthesis and biological activities of potential metabolites of the non-nucleoside reverse transcriptase inhibitor efavirenz.
Bioorganic & medicinal chemistry letters 2001;11(5):619-22.
2001: Jeffrey W Corbett; K J Kresge; S Pan; Beverly C Cordova; Ronald Klabe; James D Rodgers; Susan Erickson-Viitanen
Trifluoromethyl-containing 3-alkoxymethyl- and 3-aryloxymethyl-2-pyridinones are potent inhibitors of HIV-1 non-nucleoside reverse transcriptase.
Bioorganic & medicinal chemistry letters 2001;11(3):309-12.
2001: L Wang; Y Duan; P Stouten; George V De Lucca; Ronald Klabe; Peter A Kollman
Does a diol cyclic urea inhibitor of HIV-1 protease bind tighter than its corresponding alcohol form? A study by free energy perturbation and continuum electrostatics calculations.
Journal of computer-aided molecular design 2001;15(2):145-56.
2001: Jeffrey W Corbett; S Pan; Jay A Markwalder; Beverly C Cordova; Ronald Klabe; Sena Garber; James D Rodgers; Susan Erickson-Viitanen
3,3a-Dihydropyrano[4,3,2-de]quinazolin-2(1H)-ones are potent non-nucleoside reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(2):211-4.
2000: Mona Patel; RJ McHugh; Beverly C Cordova; Ronald Klabe; Susan Erickson-Viitanen; George L Trainor; James D Rodgers
Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters 2000;10(15):1729-31.
2000: Jeffrey W Corbett; Soo S Ko; James D Rodgers; L A Gearhart; N A Magnus; Lee Bacheler; Sharon Diamond; S Jeffrey; Ronald Klabe; Beverly C Cordova; Sena Garber; Kelly Logue; George L Trainor; PS Anderson; Susan Erickson-Viitanen
Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry 2000;43(10):2019-30.
2000: Jeffrey W Corbett; L A Gearhart; Soo S Ko; James D Rodgers; Beverly C Cordova; Ronald Klabe; Susan Erickson-Viitanen
Novel 2,2-dioxide-4,4-disubstituted-1,3-H-2,1,3-benzothiadiazines as non-nucleoside reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters 2000;10(2):193-5.
1999: Jeffrey W Corbett; Soo S Ko; James D Rodgers; S Jeffrey; Lee Bacheler; Ronald Klabe; Sharon Diamond; C M Lai; S R Rabel; JA Saye; S P Adams; George L Trainor; PS Anderson; Susan Erickson-Viitanen
Expanded-spectrum nonnucleoside reverse transcriptase inhibitors inhibit clinically relevant mutant variants of human immunodeficiency virus type 1.
Antimicrobial agents and chemotherapy 1999;43(12):2893-7.
1999: Mona Patel; RJ McHugh; Beverly C Cordova; Ronald Klabe; Susan Erickson-Viitanen; George L Trainor; Soo S Ko
Synthesis and evaluation of benzoxazinones as HIV-1 reverse transcriptase inhibitors. Analogs of Efavirenz (SUSTIVA).
Bioorganic & medicinal chemistry letters 1999;9(22):3221-4.
1999: Mona Patel; James D Rodgers; RJ McHugh; BL Johnson; Beverly C Cordova; Ronald Klabe; Lee Bacheler; Susan Erickson-Viitanen; Soo S Ko
Unsymmetrical cyclic ureas as HIV-1 protease inhibitors: novel biaryl indazoles as P2/P2' substituents.
Bioorganic & medicinal chemistry letters 1999;9(22):3217-20.
1999: Mona Patel; Soo S Ko; RJ McHugh; Jay A Markwalder; A S Srivastava; Beverly C Cordova; Ronald Klabe; Susan Erickson-Viitanen; George L Trainor; Steven P Seitz
Synthesis and evaluation of analogs of Efavirenz (SUSTIVA) as HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(19):2805-10.
1999: Robert F Kaltenbach; Ronald Klabe; Beverly C Cordova; Steven P Seitz
Increased antiviral activity of cyclic urea HIV protease inhibitors by modifying the P1/P1' substituents.
Bioorganic & medicinal chemistry letters 1999;9(15):2259-62.
1999: Joanna Trylska; Jan M Antosiewicz; Maciej Geller; Carl Nicholas Hodge; Ronald Klabe; M S Head; Michael K Gilson
Thermodynamic linkage between the binding of protons and inhibitors to HIV-1 protease.
Protein science : a publication of the Protein Society 1999;8(1):180-95.
1998: Robert F Kaltenbach; David A Nugiel; Patrick Y S Lam; Ronald Klabe; Steven P Seitz
Stereoisomers of cyclic urea HIV-1 protease inhibitors: synthesis and binding affinities.
Journal of medicinal chemistry 1998;41(25):5113-7.
1998: PJ Ala; EE Huston; Ronald Klabe; Prabhakar K Jadhav; Patrick Y S Lam; Chong-Hwan Chang
Counteracting HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with XV638 and SD146, cyclic urea amides with broad specificities.
Biochemistry 1998;37(43):15042-9.
1998: James D Rodgers; Patrick Y S Lam; BL Johnson; H Wang; R Li; Y Ru; Soo S Ko; Steven P Seitz; George L Trainor; PS Anderson; Ronald Klabe; Lee Bacheler; Beverly C Cordova; Sena Garber; C Reid; Matthew R Wright; Chong-Hwan Chang; Susan Erickson-Viitanen
Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors.
Chemistry & biology 1998;5(10):597-608.
1998: George V De Lucca; Ui Tae Kim; J Liang; Beverly C Cordova; Ronald Klabe; Sena Garber; Lee Bacheler; GN Lam; Matthew R Wright; Kelly Logue; Susan Erickson-Viitanen; Soo S Ko; George L Trainor
Nonsymmetric P2/P2' cyclic urea HIV protease inhibitors. Structure-activity relationship, bioavailability, and resistance profile of monoindazole-substituted P2 analogues.
Journal of medicinal chemistry 1998;41(13):2411-23.
1998: Ronald Klabe; Lee Bacheler; PJ Ala; Susan Erickson-Viitanen; J L Meek
Resistance to HIV protease inhibitors: a comparison of enzyme inhibition and antiviral potency.
Biochemistry 1998;37(24):8735-42.
1998: Mona Patel; Robert F Kaltenbach; David A Nugiel; RJ McHugh; Prabhakar K Jadhav; Lee Bacheler; Beverly C Cordova; Ronald Klabe; Susan Erickson-Viitanen; Sena Garber; C Reid; Steven P Seitz
The synthesis of symmetrical and unsymmetrical P1/P1' cyclic ureas as HIV protease inhibitors.
Bioorganic & medicinal chemistry letters 1998;8(9):1077-82.
1998: Mona Patel; Lee Bacheler; Marlene Rayner; Beverly C Cordova; Ronald Klabe; Susan Erickson-Viitanen; Steven P Seitz
The synthesis and evaluation of cyclic ureas as HIV protease inhibitors: modifications of the P1/P1' residues.
Bioorganic & medicinal chemistry letters 1998;8(7):823-8.
1998: James D Rodgers; BL Johnson; H Wang; Susan Erickson-Viitanen; Ronald Klabe; Lee Bacheler; Beverly C Cordova; Chong-Hwan Chang
Potent cyclic urea HIV protease inhibitors with 3-aminoindazole P2/P2' groups.
Bioorganic & medicinal chemistry letters 1998;8(7):715-20.
1997: George V De Lucca; J Liang; P E Aldrich; J Calabrese; Beverly C Cordova; Ronald Klabe; Marlene Rayner; Chong-Hwan Chang
Design, synthesis, and evaluation of tetrahydropyrimidinones as an example of a general approach to nonpeptide HIV protease inhibitors.
Journal of medicinal chemistry 1997;40(11):1707-9.
1997: David A Nugiel; K Jacobs; L Cornelius; Chong-Hwan Chang; Prabhakar K Jadhav; E R Holler; Ronald Klabe; Lee Bacheler; Beverly C Cordova; Sena Garber; C Reid; Kelly Logue; L J Gorey-Feret; GN Lam; Susan Erickson-Viitanen; Steven P Seitz
Improved P1/P1' substituents for cyclic urea based HIV-1 protease inhibitors: synthesis, structure-activity relationship, and X-ray crystal structure analysis.
Journal of medicinal chemistry 1997;40(10):1465-74.
1997: PJ Ala; EE Huston; Ronald Klabe; D D McCabe; JL Duke; CJ Rizzo; BD Korant; R J DeLoskey; Patrick Y S Lam; Carl Nicholas Hodge; Chong-Hwan Chang
Molecular basis of HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with cyclic urea inhibitors.
Biochemistry 1997;36(7):1573-80.
1996: Patrick Y S Lam; Y Ru; Prabhakar K Jadhav; P E Aldrich; G V DeLucca; C J Eyermann; Chong-Hwan Chang; G Emmett; E R Holler; W F Daneker; L Li; P N Confalone; RJ McHugh; Q Han; R Li; Jay A Markwalder; Steven P Seitz; T R Sharpe; Lee Bacheler; Marlene Rayner; Ronald Klabe; L Shum; D L Winslow; D M Kornhauser; Carl Nicholas Hodge
Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas.
Journal of medicinal chemistry 1996;39(18):3514-25.
1996: David A Nugiel; K Jacobs; Robert F Kaltenbach; T Worley; Mona Patel; D T Meyer; Prabhakar K Jadhav; George V De Lucca; T E Smyser; Ronald Klabe; Lee Bacheler; Marlene Rayner; Steven P Seitz
Preparation and structure-activity relationship of novel P1/P1'-substituted cyclic urea-based human immunodeficiency virus type-1 protease inhibitors.
Journal of medicinal chemistry 1996;39(11):2156-69.
1994: Susan Erickson-Viitanen; Ronald Klabe; P G Cawood; P L O'Neal; J L Meek
Potency and selectivity of inhibition of human immunodeficiency virus protease by a small nonpeptide cyclic urea, DMP 323.
Antimicrobial agents and chemotherapy 1994;38(7):1628-34.