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Lori Klaidman

Research Profile

Anatomy

Brain

Living Beings

Chemicals & Drugs

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Oxidation-Reduction

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Electron Spin Resonance Spectroscopy

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Publications

TOP 3
Lori K Klaidman; Jun Yang; Mei Ling Chang; James D Adams
Recent developments on the role of mitochondria in poly(ADP-ribose) polymerase inhibition.
Lori K Klaidman; Maria Morales; Seyha Kem; Jun Yang; Mei Ling Chang; James D Adams
Nicotinamide offers multiple protective mechanisms in stroke as a precursor for NAD+, as a PARP inhibitor and by partial restoration of mitochondrial function.
Lori K Klaidman; James D Adams; Robert Cross; Thomas L Pazdernik; Fred Samson
Alterations in brain glutathione homeostasis induced by the nerve gas soman.

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All Publications

2003: Lori K Klaidman; Jun Yang; Mei Ling Chang; James D Adams
Recent developments on the role of mitochondria in poly(ADP-ribose) polymerase inhibition.
Current medicinal chemistry 2003;10(24):2669-78.
2003: Lori K Klaidman; Maria Morales; Seyha Kem; Jun Yang; Mei Ling Chang; James D Adams
Nicotinamide offers multiple protective mechanisms in stroke as a precursor for NAD+, as a PARP inhibitor and by partial restoration of mitochondrial function.
Pharmacology 2003;69(3):150-7.
2003: Lori K Klaidman; James D Adams; Robert Cross; Thomas L Pazdernik; Fred Samson
Alterations in brain glutathione homeostasis induced by the nerve gas soman.
Neurotoxicity research 2003;5(3):177-82.
2002: Jun Yang; Lori K Klaidman; Artak Nalbandian; Jasmine Oliver; Mei Ling Chang; Pak H Chan; James D Adams
The effects of nicotinamide on energy metabolism following transient focal cerebral ischemia in Wistar rats.
Neuroscience letters 2002;333(2):91-4.
2002: Jun Yang; Lori K Klaidman; Mei Ling Chang; Seyha Kem; Taku Sugawara; Pak Chan; James D Adams
Nicotinamide therapy protects against both necrosis and apoptosis in a stroke model.
Pharmacology, biochemistry, and behavior 2002;73(4):901-10.
2002: James D Adams; Lori K Klaidman; Lakshmi Mishra; Betsy B Singh
Effects of guggul in a rat model of stroke.
Alternative therapies in health and medicine 2002;8(4):20-1.
2002: Mei Ling Chang; Jun Yang; Seyha Kem; Lori K Klaidman; Taku Sugawara; Pak H Chan; James D Adams
Nicotinamide and ketamine reduce infarct volume and DNA fragmentation in rats after brain ischemia and reperfusion.
Neuroscience letters 2002;322(3):137-40.
2002: Jun Yang; Lori K Klaidman; James D Adams
Medicinal chemistry of nicotinamide in the treatment of ischemia and reperfusion.
Mini reviews in medicinal chemistry 2002;2(2):125-34.
2001: James D Adams; Lori K Klaidman; Mei Ling Chang; Jun Yang
Brain oxidative stress--analytical chemistry and thermodynamics of glutathione and NADPH.
Current topics in medicinal chemistry 2001;1(6):473-82.
2001: James D Adams; Mei Ling Chang; Lori K Klaidman
Parkinson's disease--redox mechanisms.
Current medicinal chemistry 2001;8(7):809-14.
2001: Lori K Klaidman; SK Mukherjee; James D Adams
Oxidative changes in brain pyridine nucleotides and neuroprotection using nicotinamide.
Biochimica et biophysica acta 2001;1525(1-2):136-48.
1997: James D Adams; Lori K Klaidman; P Ribeiro
Tyrosine hydroxylase: mechanisms of oxygen radical formation.
Redox report : communications in free radical research 1997;3(5-6):273-9.
1997: J Grimsby; M Toth; Kevin Chen; T Kumazawa; Lori K Klaidman; James D Adams; F Karoum; J Gal; Jean C Shih
Increased stress response and beta-phenylethylamine in MAOB-deficient mice.
Nature genetics 1997;17(2):206-10.
1997: SK Mukherjee; Lori K Klaidman; R Yasharel; James D Adams
Increased brain NAD prevents neuronal apoptosis in vivo.
European journal of pharmacology 1997;330(1):27-34.
1997: Mei Ling Chang; Lori K Klaidman; James D Adams
The effects of oxidative stress on in vivo brain GSH turnover in young and mature mice.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1997;30(3):187-97.
1996: James D Adams; S K Mukherjee; Lori K Klaidman; Mei Ling Chang; R Yasharel
Apoptosis and oxidative stress in the aging brain.
Annals of the New York Academy of Sciences 1996;786():135-51.
1996: Lori K Klaidman; S K Mukherjee; T P Hutchin; James D Adams
Nicotinamide as a precursor for NAD+ prevents apoptosis in the mouse brain induced by tertiary-butylhydroperoxide.
Neuroscience letters 1996;206(1):5-8.
1995: Mei Ling Chang; Lori K Klaidman; James D Adams
Age-dependent effects of t-BuOOH on glutathione disulfide reductase, glutathione peroxidase, and malondialdehyde in the brain.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1995;26(2):95-106.
1995: Lori K Klaidman; A C Leung; James D Adams
High-performance liquid chromatography analysis of oxidized and reduced pyridine dinucleotides in specific brain regions.
Analytical biochemistry 1995;228(2):312-7.
1995: S K Mukherjee; R Yasharel; Lori K Klaidman; T P Hutchin; James D Adams
Apoptosis and DNA fragmentation as induced by tertiary butylhydroperoxide in the brain.
Brain research bulletin 1995;38(6):595-604.
1994: James D Adams; Lori K Klaidman; Y M Huang; J J Cheng; Z J Wang; M Nguyen; B Knüsel; A Kuda
The neuropathology of intracerebroventricular t-butylhydroperoxide.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1994;22(2):123-42.
1993: James D Adams; Lori K Klaidman
Acrolein-induced oxygen radical formation.
Free radical biology & medicine 1993;15(2):187-93.
1993: James D Adams; Lori K Klaidman; A C Leung
MPP+ and MPDP+ induced oxygen radical formation with mitochondrial enzymes.
Free radical biology & medicine 1993;15(2):181-6.
1993: Lori K Klaidman; James D Adams; A C Leung; S S Kim; Enrique Cadenas
Redox cycling of MPP+: evidence for a new mechanism involving hydride transfer with xanthine oxidase, aldehyde dehydrogenase, and lipoamide dehydrogenase.
Free radical biology & medicine 1993;15(2):169-79.
1993: James D Adams; B Wang; Lori K Klaidman; C P LeBel; I N Odunze; D Shah
New aspects of brain oxidative stress induced by tert-butylhydroperoxide.
Free radical biology & medicine 1993;15(2):195-202.
1993: Lori K Klaidman; J Tombran-Tink; James D Adams; Lincoln V Johnson
Effects of medium conditioned by retinal pigmented epithelial cells on neurotransmitter phenotype in retinoblastoma cells.
Cancer letters 1993;68(2-3):207-13.
1993: James D Adams; G S Jaresko; Stan Louie; Lori K Klaidman; D Kennedy; Om P Sharma; C T Boylen
Pneumocystis carinii pneumonia in HIV infected patients: effects of the diseases on glutathione and glutathione disulfide.
Journal of medicine 1993;24(6):337-52.
1992: James D Adams; Lori K Klaidman; Enrique Cadenas
MPP+ redox cycling: a new mechanism involving hydride transfer.
Annals of the New York Academy of Sciences 1992;648():239-40.
1991: James D Adams; Lori K Klaidman; I N Odunze; H C Shen; C A Miller
Alzheimer's and Parkinson's disease. Brain levels of glutathione, glutathione disulfide, and vitamin E.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1991;14(3):213-26.
1991: James D Adams; Lori K Klaidman; I N Odunze; J N Johannessen
Effects of MPTP on the cerebrovasculature.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1991;9(2):155-9.
1990: I N Odunze; Lori K Klaidman; James D Adams
MPTP toxicity in the mouse brain and vitamin E.
Neuroscience letters 1990;108(3):346-9.