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Lynell Klassen

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Daniel R Anderson; Michael J Duryee; Robert P Garvin; Lynell W Klassen; Ted R Mikuls; Joseph T Poterucha; Scott W Shurmur; Geoffrey M Thiele
IL-6 and its receptors in coronary artery disease and acute myocardial infarction.
Robert P Garvin; Lynell W Klassen; Geoffrey M Thiele; Michael J Duryee; Daniel R Anderson
Ultrasound imaging in an animal model of vascular inflammation following balloon injury.
Geoffrey M Thiele; Dong Wang; Jordan P Lacy; Ted R Mikuls; James R O'Dell; Daniel R Anderson; Michael J Duryee; Anand Dusad; Carlos D Hunter; Lynell W Klassen
Citrullinated mouse collagen administered to DBA/1J mice in the absence of adjuvant initiates arthritis.

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2013: Daniel R Anderson; Michael J Duryee; Robert P Garvin; Lynell W Klassen; Ted R Mikuls; Joseph T Poterucha; Scott W Shurmur; Geoffrey M Thiele
IL-6 and its receptors in coronary artery disease and acute myocardial infarction.
Cytokine 2013;62(3):395-400.
2012: Robert P Garvin; Lynell W Klassen; Geoffrey M Thiele; Michael J Duryee; Daniel R Anderson
Ultrasound imaging in an animal model of vascular inflammation following balloon injury.
Ultrasound in medicine & biology 2012;38(9):1552-8.
2012: Geoffrey M Thiele; Dong Wang; Jordan P Lacy; Ted R Mikuls; James R O'Dell; Daniel R Anderson; Michael J Duryee; Anand Dusad; Carlos D Hunter; Lynell W Klassen
Citrullinated mouse collagen administered to DBA/1J mice in the absence of adjuvant initiates arthritis.
International immunopharmacology 2012;13(4):424-31.
2012: Maseeha S Khaleel; Lynell W Klassen; Geoffrey M Thiele; Walter D Bussey; Tracy A Dorheim; Harold E Durbin; Michael J Duryee; Robert P Garvin; Daniel R Anderson
High-pressure distention of the saphenous vein during preparation results in increased markers of inflammation: a potential mechanism for graft failure.
The Annals of thoracic surgery 2012;93(2):552-8.
2012: Daniel R Anderson; Michael D Boska; Michael J Duryee; Robert P Garvin; Geoffrey M Thiele; Lynell W Klassen
A method for the making and utility of gadolinium-labeled albumin microbubbles.
Magnetic resonance imaging 2012;30(1):96-103.
2010: Daniel R Anderson; Michael J Duryee; Rajeev K Anchan; Robert P Garvin; Michael D Johnston; Thomas R Porter; Geoffrey M Thiele; Lynell W Klassen
Albumin-based microbubbles bind up-regulated scavenger receptors following vascular injury.
The Journal of biological chemistry 2010;285(52):40645-53.
2010: Geoffrey M Thiele; Michael J Duryee; Monte Willis; Dean J Tuma; Stanley J Radio; Carlos D Hunter; Courtney S Schaffert; Lynell W Klassen
Autoimmune hepatitis induced by syngeneic liver cytosolic proteins biotransformed by alcohol metabolites.
Alcoholism, clinical and experimental research 2010;34(12):2126-36.
2010: Michael J Duryee; Lynell W Klassen; Courtney S Schaffert; Dean J Tuma; Carlos D Hunter; Robert P Garvin; Daniel R Anderson; Geoffrey M Thiele
Malondialdehyde-acetaldehyde adduct is the dominant epitope after MDA modification of proteins in atherosclerosis.
Free radical biology & medicine 2010;49(10):1480-6.
2010: Courtney S Schaffert; Michael J Duryee; Robert G Bennett; Amy L DeVeney; Dean J Tuma; Peter Olinga; Karen C Easterling; Geoffrey M Thiele; Lynell W Klassen
Exposure of precision-cut rat liver slices to ethanol accelerates fibrogenesis.
American journal of physiology. Gastrointestinal and liver physiology 2010;299(3):G661-8.
2009: Courtney S Schaffert; Michael J Duryee; Carlos D Hunter; Bartlett C Hamilton; Amy L DeVeney; Mary M Huerter; Lynell W Klassen; Geoffrey M Thiele
Alcohol metabolites and lipopolysaccharide: roles in the development and/or progression of alcoholic liver disease.
World journal of gastroenterology : WJG 2009;15(10):1209-18.
2008: Lynell W Klassen; Geoffrey M Thiele; Michael J Duryee; Courtney S Schaffert; Amy L DeVeney; Carlos D Hunter; Peter Olinga; Dean J Tuma
An in vitro method of alcoholic liver injury using precision-cut liver slices from rats.
Biochemical pharmacology 2008;76(3):426-36.
2008: Michael J Duryee; Lynell W Klassen; Bonnie L Jones; Monte Willis; Dean J Tuma; Geoffrey M Thiele
Increased immunogenicity to P815 cells modified with malondialdehyde and acetaldehyde.
International immunopharmacology 2008;8(8):1112-8.
2008: Geoffrey M Thiele; Lynell W Klassen; Dean J Tuma
Formation and immunological properties of aldehyde-derived protein adducts following alcohol consumption.
Methods in molecular biology (Clifton, N.J.) 2008;447():235-57.
2007: Michael J Duryee; Lynell W Klassen; Geoffrey M Thiele
Immunological response in alcoholic liver disease.
World journal of gastroenterology : WJG 2007;13(37):4938-46.
2005: Geoffrey M Thiele; Michael J Duryee; Thomas L Freeman; Michael F Sorrell; Monte Willis; Dean J Tuma; Lynell W Klassen
Rat sinusoidal liver endothelial cells (SECs) produce pro-fibrotic factors in response to adducts formed from the metabolites of ethanol.
Biochemical pharmacology 2005;70(11):1593-600.
2005: Michael J Duryee; Thomas L Freeman; Monte Willis; Carlos D Hunter; Bartlett C Hamilton; Hiroshi Suzuki; Dean J Tuma; Lynell W Klassen; Geoffrey M Thiele
Scavenger receptors on sinusoidal liver endothelial cells are involved in the uptake of aldehyde-modified proteins.
Molecular pharmacology 2005;68(5):1423-30.
2005: Jan B Hoek; Geoffrey M Thiele; Lynell W Klassen; Pranoti Mandrekar; Samir Zakhari; Robert T Cook; Nancy B Ray; Kyle I Happel; Jay K Kolls; Elizabeth J Kovacs; Gyongyi Szab
RSA 2004: combined basic research satellite symposium-mechanisms of alcohol-mediated organ and tissue damage: inflammation and immunity and alcohol and mitochondrial metabolism: at the crossroads of life and death session one: alcohol, cellular and organ damage.
Alcoholism, clinical and experimental research 2005;29(9):1735-43.
2005: Thomas L Freeman; Dean J Tuma; Geoffrey M Thiele; Lynell W Klassen; Simon Worrall; Onni Niemelä; Seppo Parkkila; Peter W Emery; Victor R Preedy
Recent advances in alcohol-induced adduct formation.
Alcoholism, clinical and experimental research 2005;29(7):1310-6.
2005: Thomas L Freeman; Alvin Haver; Michael J Duryee; Dean J Tuma; Lynell W Klassen; Frederick G Hamel; Ronda L White; Stephen I Rennard; Geoffrey M Thiele
Aldehydes in cigarette smoke react with the lipid peroxidation product malonaldehyde to form fluorescent protein adducts on lysines.
Chemical research in toxicology 2005;18(5):817-24.
2004: Michael J Duryee; Lynell W Klassen; Thomas L Freeman; Monte Willis; Dean J Tuma; Geoffrey M Thiele
Lipopolysaccharide is a cofactor for malondialdehyde-acetaldehyde adduct-mediated cytokine/chemokine release by rat sinusoidal liver endothelial and Kupffer cells.
Alcoholism, clinical and experimental research 2004;28(12):1931-8.
2004: Michael J Duryee; Monte Willis; Thomas L Freeman; Charles A Kuszynski; Dean J Tuma; Lynell W Klassen; Geoffrey M Thiele
Mechanisms of alcohol liver damage: aldehydes, scavenger receptors, and autoimmunity.
Frontiers in bioscience : a journal and virtual library 2004;9():3145-55.
2004: Geoffrey M Thiele; Thomas L Freeman; Lynell W Klassen
Immunologic mechanisms of alcoholic liver injury.
Seminars in liver disease 2004;24(3):273-87.
2004: Thomas L Freeman; Geoffrey M Thiele; Lynell W Klassen; B T Klassen; Mark E Mailliard
N-(methylamino)isobutyric acid inhibits proliferation of CFSC-2C hepatic stellate cells.
Biochemical pharmacology 2004;68(2):223-30.
2004: Monte Willis; Lynell W Klassen; Deborah L Carlson; Chad F Brouse; Geoffrey M Thiele
Malondialdehyde-acetaldehyde haptenated protein binds macrophage scavenger receptor(s) and induces lysosomal damage.
International immunopharmacology 2004;4(7):885-99.
2003: Monte Willis; Geoffrey M Thiele; Dean J Tuma; Lynell W Klassen
T cell proliferative responses to malondialdehyde-acetaldehyde haptenated protein are scavenger receptor mediated.
International immunopharmacology 2003;3(10-11):1381-99.
2003: Michael J Duryee; Lynell W Klassen; Thomas L Freeman; Monte Willis; Dean J Tuma; Geoffrey M Thiele
Chronic ethanol consumption impairs receptor-mediated endocytosis of MAA-modified albumin by liver endothelial cells.
Biochemical pharmacology 2003;66(6):1045-54.
2002: James R O'Dell; Robert Leff; Gail Paulsen; Claire Haire; Jack A Mallek; P James Eckhoff; Ana Fernandez; Kent Blakely; Steven Wees; Julie A Stoner; Stephen Hadley; Jeffrey Felt; William Palmer; Paul Waytz; Melvin Churchill; Lynell W Klassen; Gerald Moore
Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine, methotrexate and sulfasalazine, or a combination of the three medications: results of a two-year, randomized, double-blind, placebo-controlled trial.
Arthritis and rheumatism 2002;46(5):1164-70.
2002: Monte Willis; Lynell W Klassen; Dean J Tuma; Geoffrey M Thiele
Malondialdehyde-acetaldehyde-haptenated protein induces cell death by induction of necrosis and apoptosis in immune cells.
International immunopharmacology 2002;2(4):519-35.
2002: Monte Willis; Lynell W Klassen; Dean J Tuma; Michael F Sorrell; Geoffrey M Thiele
In vitro exposure to malondialdehyde-acetaldehyde adducted protein inhibits cell proliferation and viability.
Alcoholism, clinical and experimental research 2002;26(2):158-64.
2002: Monte Willis; Lynell W Klassen; Dean J Tuma; Michael F Sorrell; Geoffrey M Thiele
Adduction of soluble proteins with malondialdehyde-acetaldehyde (MAA) induces antibody production and enhances T-cell proliferation.
Alcoholism, clinical and experimental research 2002;26(1):94-106.
2001: James R O'Dell; K W Blakely; Jack A Mallek; P James Eckhoff; Robert Leff; Steven Wees; K M Sems; A M Fernandez; William Palmer; Lynell W Klassen; Gail Paulsen; Claire Haire; Gary F Moore
Treatment of early seropositive rheumatoid arthritis: a two-year, double-blind comparison of minocycline and hydroxychloroquine.
Arthritis and rheumatism 2001;44(10):2235-41.
2001: Lynell W Klassen
Intensive immunosuppression with autologous hematopoietic stem cell reconstitution as therapy for rheumatoid arthritis.
The Journal of rheumatology. Supplement 2001;64():3-4.
2001: Steven Z Pavletic; Lynell W Klassen; R Pope; James R O'Dell; A E Traynor; Claire Haire; F Graziano; Y Oyama; W Barr; R K Burt
Treatment of relapse after autologous blood stem cell transplantation for severe rheumatoid arthritis.
The Journal of rheumatology. Supplement 2001;64():28-31.
2001: Steven Z Pavletic; J R Odell; Samuel J Pirruccello; Mary Margaret Ursick; Claire Haire; J Graham Sharp; Anne Kessinger; Lynell W Klassen
Intensive immunoablation and autologous blood stem cell transplantation in patients with refractory rheumatoid arthritis: the University of Nebraska experience.
The Journal of rheumatology. Supplement 2001;64():13-20.
2001: Dean J Tuma; Mark Kearley; Geoffrey M Thiele; Simon Worrall; A Haver; Lynell W Klassen; Michael F Sorrell
Elucidation of reaction scheme describing malondialdehyde-acetaldehyde-protein adduct formation.
Chemical research in toxicology 2001;14(7):822-32.
2001: Geoffrey M Thiele; Simon Worrall; Dean J Tuma; Lynell W Klassen; Todd A Wyatt; N Nagata
The chemistry and biological effects of malondialdehyde-acetaldehyde adducts.
Alcoholism, clinical and experimental research 2001;25(5 Suppl ISBRA):218S-224S.
2000: Roberta Rolla; Daria Vay; Elisa Mottaran; M Parodi; Nicola Traverso; S Aricó; Massimo Sartori; Giorgio Bellomo; Lynell W Klassen; Geoffrey M Thiele; Dean J Tuma; Emanuele Albano
Detection of circulating antibodies against malondialdehyde-acetaldehyde adducts in patients with alcohol-induced liver disease.
Hepatology (Baltimore, Md.) 2000;31(4):878-84.
1999: James R O'Dell; Gail Paulsen; Claire Haire; Kent Blakely; William Palmer; Steven Wees; P James Eckhoff; Lynell W Klassen; Melvin Churchill; D Doud; A Weaver; Gary F Moore
Treatment of early seropositive rheumatoid arthritis with minocycline: four-year followup of a double-blind, placebo-controlled trial.
Arthritis and rheumatism 1999;42(8):1691-5.
1999: James R O'Dell; Gary F Moore; Lynell W Klassen
Combination therapy in rheumatoid arthritis: a comment.
Rheumatology (Oxford, England) 1999;38(6):577.
1999: Geoffrey M Thiele; J A Miller; Lynell W Klassen; Dean J Tuma
Chronic ethanol consumption impairs receptor-mediated endocytosis of formaldehyde-treated albumin by isolated rat liver endothelial cells.
Hepatology (Baltimore, Md.) 1999;29(5):1511-7.
1999: Lynell W Klassen; B L Jones; Michael F Sorrell; Dean J Tuma; Geoffrey M Thiele
Conversion of acetaldehyde-protein adduct epitopes from a nonreduced to a reduced phenotype by antigen processing cells.
Alcoholism, clinical and experimental research 1999;23(4):657-63.
1998: Geoffrey M Thiele; Dean J Tuma; JA Miller; K M Wegter; Thomas L McDonald; Lynell W Klassen
Monoclonal and polyclonal antibodies recognizing acetaldehyde-protein adducts.
Biochemical pharmacology 1998;56(11):1515-23.
1998: G E Hill; JA Miller; B Timothy Baxter; Lynell W Klassen; Michael J Duryee; Dean J Tuma; Geoffrey M Thiele
Association of malondialdehyde-acetaldehyde (MAA) adducted proteins with atherosclerotic-induced vascular inflammatory injury.
Atherosclerosis 1998;141(1):107-16.
1998: Geoffrey M Thiele; Dean J Tuma; Monte Willis; JA Miller; Thomas L McDonald; Michael F Sorrell; Lynell W Klassen
Soluble proteins modified with acetaldehyde and malondialdehyde are immunogenic in the absence of adjuvant.
Alcoholism, clinical and experimental research 1998;22(8):1731-9.
1998: D Xu; Geoffrey M Thiele; J L Beckenhauer; Lynell W Klassen; Michael F Sorrell; Dean J Tuma
Detection of circulating antibodies to malondialdehyde-acetaldehyde adducts in ethanol-fed rats.
Gastroenterology 1998;115(3):686-92.
1998: Lynell W Klassen; Geoffrey M Thiele
Immune reactivity to proteins biotransformed by alcohol metabolites.
Alcoholism, clinical and experimental research 1998;22(5 Suppl):204S-207S.
1998: James R O'Dell; BS Nepom; Claire Haire; Vivian H Gersuk; Lakshmi K Gaur; Gary F Moore; W Drymalski; William Palmer; P James Eckhoff; Lynell W Klassen; Steven Wees; Geoffrey M Thiele; Gerald Nepom
HLA-DRB1 typing in rheumatoid arthritis: predicting response to specific treatments.
Annals of the rheumatic diseases 1998;57(4):209-13.
1997: D Xu; Geoffrey M Thiele; Mark Kearley; M D Haugen; Lynell W Klassen; Michael F Sorrell; Dean J Tuma
Epitope characterization of malondialdehyde-acetaldehyde adducts using an enzyme-linked immunosorbent assay.
Chemical research in toxicology 1997;10(9):978-86.
1997: James R O'Dell; Claire Haire; William Palmer; W Drymalski; Steven Wees; Kent Blakely; Melvin Churchill; P James Eckhoff; A Weaver; D Doud; N Erikson; Frederick Dietz; Richard R. Olson; P Maloley; Lynell W Klassen; Gary F Moore
Treatment of early rheumatoid arthritis with minocycline or placebo: results of a randomized, double-blind, placebo-controlled trial.
Arthritis and rheumatism 1997;40(5):842-8.
1996: Geoffrey M Thiele; J A Miller; Lynell W Klassen; Dean J Tuma
Long-term ethanol administration alters the degradation of acetaldehyde adducts by liver endothelial cells.
Hepatology (Baltimore, Md.) 1996;24(3):643-8.
1996: James R O'Dell; Claire Haire; N Erikson; W Drymalski; William Palmer; P James Eckhoff; V Garwood; P Maloley; Lynell W Klassen; Steven Wees; H Klein; Gary F Moore
Treatment of rheumatoid arthritis with methotrexate alone, sulfasalazine and hydroxychloroquine, or a combination of all three medications.
The New England journal of medicine 1996;334(20):1287-91.
1996: J R Oʼdell; William Palmer; J Gilg; Claire Haire; Lynell W Klassen; G Moore
Pneumococcal vaccine in rheumatoid arthritis.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 1996;2(2):59-63.
1996: Dean J Tuma; Geoffrey M Thiele; D Xu; Lynell W Klassen; M F Sorrell
Acetaldehyde and malondialdehyde react together to generate distinct protein adducts in the liver during long-term ethanol administration.
Hepatology (Baltimore, Md.) 1996;23(4):872-80.
1996: James R O'Dell; Claire Haire; N Erikson; W Drymalski; William Palmer; P Maloley; Lynell W Klassen; Steven Wees; Gary F Moore
Efficacy of triple DMARD therapy in patients with RA with suboptimal response to methotrexate.
The Journal of rheumatology. Supplement 1996;44():72-4.
1995: Margaret A Tempero; Y Haga; C Sivinski; D Birt; Lynell W Klassen; G Thiele
Immunologic effects of levamisole in mice and humans: evidence for augmented antibody response without modulation of cellular cytotoxicity.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1995;17(1):47-57.
1994: Geoffrey M Thiele; K M Wegter; Michael F Sorrell; Dean J Tuma; Thomas L McDonald; Lynell W Klassen
Specificity of N-ethyl lysine of a monoclonal antibody to acetaldehyde-modified proteins prepared under reducing conditions.
Biochemical pharmacology 1994;48(1):183-9.
1994: Lynell W Klassen; Dean J Tuma; Michael F Sorrell; Thomas L McDonald; J M DeVasure; Geoffrey M Thiele
Detection of reduced acetaldehyde protein adducts using a unique monoclonal antibody.
Alcoholism, clinical and experimental research 1994;18(1):164-71.
1993: James R O'Dell; Lynell W Klassen; Gary F Moore
The use of outcome measures to evaluate clinical rheumatology curriculum changes.
The Journal of rheumatology 1993;20(6):1033-6.
1993: S W Braddock; H D Kay; D Maennle; Thomas L McDonald; Samuel J Pirruccello; A Masih; Lynell W Klassen; A R Sawka
Clinical and immunologic studies in reticular erythematous mucinosis and Jessner's lymphocytic infiltrate of skin.
Journal of the American Academy of Dermatology 1993;28(5 Pt 1):691-5.
1992: L H Anderson; Thomas L McDonald; Geoffrey M Thiele; Lynell W Klassen
Comparison of the use of bulk to micro culture of cell preparations for lymphokine-activated cytotoxicity assays.
Journal of clinical laboratory analysis 1992;6(3):113-8.
1991: James R O'Dell; S Lemley-Gillespie; W R Palmer; A L Weaver; Gary F Moore; Lynell W Klassen
Serum selenium concentrations in rheumatoid arthritis.
Annals of the rheumatic diseases 1991;50(6):376-8.
1990: Margaret A Tempero; C Sivinski; Z Steplewski; E Harvey; Lynell W Klassen; H D Kay
Phase II trial of interferon gamma and monoclonal antibody 17-1A in pancreatic cancer: biologic and clinical effects.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1990;8(12):2019-26.
1990: Lynell W Klassen; D S Xu; Dean J Tuma
Immune response to acetaldehyde adducts.
Progress in clinical and biological research 1990;325():333-40.
1989: H T Petrie; Lynell W Klassen; P S Klassen; James R O'Dell; H D Kay
Selenium and the immune response: 2. Enhancement of murine cytotoxic T-lymphocyte and natural killer cell cytotoxicity in vivo.
Journal of leukocyte biology 1989;45(3):215-20.
1989: H T Petrie; Lynell W Klassen; H D Kay
Selenium and the immune response: 1. Modulation of alloreactive human lymphocyte functions in vitro.
Journal of leukocyte biology 1989;45(3):207-14.
1988: James R O'Dell; J P McGivern; H D Kay; Lynell W Klassen
Improved survival in murine lupus as the result of selenium supplementation.
Clinical and experimental immunology 1988;73(2):322-7.
1986: H D Kay; Lynell W Klassen
Peripheral blood granulocytes as effectors of regulation for the human natural killer cell system. A review.
Natural immunity and cell growth regulation 1986;5(1):1-18.