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Richard Klausner
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38
Rouault, Tracey
26
Bonifacino, Juan
22
Dancis, Andrew
19
Samelson, Lawrence
17
Linehan, Marston
15
Lippincott-Schwartz, Jennifer
13
Donaldson, Julie
13
Haile, David
12
Hentze, Matthias
11
Stearman, Robert
10
Pause, Arnim
10
Weissman, Allan
8
Yuan, Daniel
7
Gnarra, JR
7
Ashwell, Jonathan
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All Publications
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2006: Riss Joseph; Khanna Chand; Koo Seongjoon; Chandramouli Gadisetti V R; Yang Howard H; Hu Ying; Kleiner David E; Rosenwald Andreas; Schaefer Carl F; Ben-Sasson Shmuel A; Yang Liming; Powell John; Kane David W; Star Robert A; Aprelikova Olga; Bauer Kristin; Vasselli James R; Maranchie Jodi K; Kohn Kurt W; Buetow Ken H; Linehan W Marston; Weinstein John N; Lee Maxwell P; Klausner Richard D; Barrett J Carl
Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinoma.
Cancer research 2006;66(14):7216-24.
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2004: Maranchie Jodi K; Afonso Anoushka; Albert Paul S; Kalyandrug Sivaram; Phillips John L; Zhou Shubo; Peterson James; Ghadimi Bijan M; Hurley Katheen; Riss Joseph; Vasselli James R; Ried Thomas; Zbar Berton; Choyke Peter; Walther McClellan M; Klausner Richard D; Linehan W Marston
Solid renal tumor severity in von Hippel Lindau disease is related to germline deletion length and location.
Human mutation 2004;23(1):40-6.
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2003: Vasselli James R; Shih Joanna H; Iyengar Shuba R; Maranchie Jodi; Riss Joseph; Worrell Robert; Torres-Cabala Carlos; Tabios Ray; Mariotti Andra; Stearman Robert; Merino Maria; Walther McClellan M; Simon Richard; Klausner Richard D; Linehan W Marston
Predicting survival in patients with metastatic kidney cancer by gene-expression profiling in the primary tumor.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(12):6958-63.
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2002: Brower Christopher S; Sato Shigeo; Tomomori-Sato Chieri; Kamura Takumi; Pause Arnim; Stearman Robert; Klausner Richard D; Malik Sohail; Lane William S; Sorokina Irina; Roeder Robert G; Conaway Joan Weliky; Conaway Ronald C
Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10353-8.
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2002: Bindra Ranjit S; Vasselli James R; Stearman Robert; Linehan W Marston; Klausner Richard D
VHL-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells.
Cancer research 2002;62(11):3014-9.
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2002: Buetow Kenneth H; Klausner Richard D; Fine Howard; Kaplan Richard; Singer Dinah S; Strausberg Robert L
Cancer Molecular Analysis Project: weaving a rich cancer research tapestry.
Cancer cell 2002;1(4):315-8.
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2002: Maranchie Jodi K; Vasselli James R; Riss Joseph; Bonifacino Juan S; Linehan W Marston; Klausner Richard D
The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma.
Cancer cell 2002;1(3):247-55.
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2002: Klausner Richard D
The fabric of cancer cell biology-Weaving together the strands.
Cancer cell 2002;1(1):3-10.
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2002: Knight Simon A B; Lesuisse Emmanuel; Stearman Robert; Klausner Richard D; Dancis Andrew
Reductive iron uptake by Candida albicans: role of copper, iron and the TUP1 regulator.
Microbiology (Reading, England) 2002;148(Pt 1):29-40.
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2001: Phillips J L; Ghadimi B M; Wangsa D; Padilla-Nash H; Worrell R; Hewitt S; Walther M; Linehan W M; Klausner R D; Ried T
Molecular cytogenetic characterization of early and late renal cell carcinomas in von Hippel-Lindau disease.
Genes, chromosomes & cancer 2001;31(1):1-9.
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2001: Goldin D S; Dahl C A; Olsen K L; Ostrach L H; Klausner R D
Biomedicine. The NASA-NCI collaboration on biomolecular sensors.
Science (New York, N.Y.) 2001;292(5516):443-4.
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2001: de Paulsen N; Brychzy A; Fournier M C; Klausner R D; Gnarra J R; Pause A; Lee S
Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1387-92.
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2000: Strausberg R L; Buetow K H; Emmert-Buck M R; Klausner R D
The cancer genome anatomy project: building an annotated gene index.
Trends in genetics : TIG 2000;16(3):103-6.
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1999: Pack S D; Zbar B; Pak E; Ault D O; Humphrey J S; Pham T; Hurley K; Weil R J; Park W S; Kuzmin I; Stolle C; Glenn G; Liotta L A; Lerman M I; Klausner R D; Linehan W M; Zhuang Z
Constitutional von Hippel-Lindau (VHL) gene deletions detected in VHL families by fluorescence in situ hybridization.
Cancer research 1999;59(21):5560-4.
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1999: Iwai K; Yamanaka K; Kamura T; Minato N; Conaway R C; Conaway J W; Klausner R D; Pause A
Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12436-41.
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1999: Strausberg R L; Feingold E A; Klausner R D; Collins F S
The mammalian gene collection.
Science (New York, N.Y.) 1999;286(5439):455-7.
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1999: Klausner R D
Studying cancer in the mouse.
Oncogene 1999;18(38):5249-52.
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1999: Koochekpour S; Jeffers M; Wang P H; Gong C; Taylor G A; Roessler L M; Stearman R; Vasselli J R; Stetler-Stevenson W G; Kaelin W G; Linehan W M; Klausner R D; Gnarra J R; Vande Woude G F
The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells.
Molecular and cellular biology 1999;19(9):5902-12.
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1999: Pause A; Peterson B; Schaffar G; Stearman R; Klausner R D
Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(17):9533-8.
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1999: Lee S; Neumann M; Stearman R; Stauber R; Pause A; Pavlakis G N; Klausner R D
Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein.
Molecular and cellular biology 1999;19(2):1486-97.
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1999: Klausner R D
Cancer, genomics, and the National Cancer Institute.
The Journal of clinical investigation 1999;104 Suppl():S15-7.
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1998: Liu E; Nealon E; Klausner R
Perspective from the National Cancer Institute (NCI).
Breast disease 1998;10(5-6):29-31.
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1998: Philpott C C; Rashford J; Yamaguchi-Iwai Y; Rouault T A; Dancis A; Klausner R D
Cell-cycle arrest and inhibition of G1 cyclin translation by iron in AFT1-1(up) yeast.
The EMBO journal 1998;17(17):5026-36.
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1998: Hochstenbach F; Klis F M; van den Ende H; van Donselaar E; Peters P J; Klausner R D
Identification of a putative alpha-glucan synthase essential for cell wall construction and morphogenesis in fission yeast.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9161-6.
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1998: Stearman R; Dancis A; Klausner R D
YIpDCE1 - an integrating plasmid for dual constitutive expression in yeast.
Gene 1998;212(2):197-202.
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1998: Klausner R
Breast disease. Foreword.
Breast disease 1998;10(1-2):1.
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1998: Iwai K; Drake S K; Wehr N B; Weissman A M; LaVaute T; Minato N; Klausner R D; Levine R L; Rouault T A
Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: implications for degradation of oxidized proteins.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(9):4924-8.
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1998: Gaxiola R A; Yuan D S; Klausner R D; Fink G R
The yeast CLC chloride channel functions in cation homeostasis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):4046-50.
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1998: Pause A; Lee S; Lonergan K M; Klausner R D
The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(3):993-8.
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1998: Stolle C; Glenn G; Zbar B; Humphrey J S; Choyke P; Walther M; Pack S; Hurley K; Andrey C; Klausner R; Linehan W M
Improved detection of germline mutations in the von Hippel-Lindau disease tumor suppressor gene.
Human mutation 1998;12(6):417-23.
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1997: Addess K J; Basilion J P; Klausner R D; Rouault T A; Pardi A
Structure and dynamics of the iron responsive element RNA: implications for binding of the RNA by iron regulatory binding proteins.
Journal of molecular biology 1997;274(1):72-83.
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1997: Yuan D S; Dancis A; Klausner R D
Restriction of copper export in Saccharomyces cerevisiae to a late Golgi or post-Golgi compartment in the secretory pathway.
The Journal of biological chemistry 1997;272(41):25787-93.
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1997: Kramer B S; Klausner R D
Grappling with cancer--defeatism versus the reality of progress.
The New England journal of medicine 1997;337(13):931-4; discussion 937-8.
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1997: Hung I H; Suzuki M; Yamaguchi Y; Yuan D S; Klausner R D; Gitlin J D
Biochemical characterization of the Wilson disease protein and functional expression in the yeast Saccharomyces cerevisiae.
The Journal of biological chemistry 1997;272(34):21461-6.
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1997: Gnarra J R; Ward J M; Porter F D; Wagner J R; Devor D E; Grinberg A; Emmert-Buck M R; Westphal H; Klausner R D; Linehan W M
Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9102-7.
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1997: Yamaguchi-Iwai Y; Serpe M; Haile D; Yang W; Kosman D J; Klausner R D; Dancis A
Homeostatic regulation of copper uptake in yeast via direct binding of MAC1 protein to upstream regulatory sequences of FRE1 and CTR1.
The Journal of biological chemistry 1997;272(28):17711-8.
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1997: Humphrey J S; Salim A; Erdos M R; Collins F S; Brody L C; Klausner R D
Human BRCA1 inhibits growth in yeast: potential use in diagnostic testing.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(11):5820-5.
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1997: Strausberg R L; Dahl C A; Klausner R D
New opportunities for uncovering the molecular basis of cancer.
Nature genetics 1997;15 Spec No():415-6.
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1997: Klomp L W; Lin S J; Yuan D S; Klausner R D; Culotta V C; Gitlin J D
Identification and functional expression of HAH1, a novel human gene involved in copper homeostasis.
The Journal of biological chemistry 1997;272(14):9221-6.
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1997: Pause A; Lee S; Worrell R A; Chen D Y; Burgess W H; Linehan W M; Klausner R D
The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2156-61.
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1997: Rouault T; Klausner R
Regulation of iron metabolism in eukaryotes.
Current topics in cellular regulation 1997;35():1-19.
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1996: Finegold A A; Shatwell K P; Segal A W; Klausner R D; Dancis A
Intramembrane bis-heme motif for transmembrane electron transport conserved in a yeast iron reductase and the human NADPH oxidase.
The Journal of biological chemistry 1996;271(49):31021-4.
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1996: Gnarra J R; Zhou S; Merrill M J; Wagner J R; Krumm A; Papavassiliou E; Oldfield E H; Klausner R D; Linehan W M
Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):10589-94.
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1996: Kim H Y; LaVaute T; Iwai K; Klausner R D; Rouault T A
Identification of a conserved and functional iron-responsive element in the 5'-untranslated region of mammalian mitochondrial aconitase.
The Journal of biological chemistry 1996;271(39):24226-30.
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1996: Radhakrishna H; Klausner R D; Donaldson J G
Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase.
The Journal of cell biology 1996;134(4):935-47.
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1996: Ooi C E; Rabinovich E; Dancis A; Bonifacino J S; Klausner R D
Copper-dependent degradation of the Saccharomyces cerevisiae plasma membrane copper transporter Ctr1p in the apparent absence of endocytosis.
The EMBO journal 1996;15(14):3515-23.
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1996: Yamaguchi-Iwai Y; Stearman R; Dancis A; Klausner R D
Iron-regulated DNA binding by the AFT1 protein controls the iron regulon in yeast.
The EMBO journal 1996;15(13):3377-84.
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1996: Shatwell K P; Dancis A; Cross A R; Klausner R D; Segal A W
The FRE1 ferric reductase of Saccharomyces cerevisiae is a cytochrome b similar to that of NADPH oxidase.
The Journal of biological chemistry 1996;271(24):14240-4.
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1996: Rouault T A; Klausner R D
Iron-sulfur clusters as biosensors of oxidants and iron.
Trends in biochemical sciences 1996;21(5):174-7.
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1996: Butt J; Kim H Y; Basilion J P; Cohen S; Iwai K; Philpott C C; Altschul S; Klausner R D; Rouault T A
Differences in the RNA binding sites of iron regulatory proteins and potential target diversity.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):4345-9.
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1996: Lee S; Chen D Y; Humphrey J S; Gnarra J R; Linehan W M; Klausner R D
Nuclear/cytoplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell density.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(5):1770-5.
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1996: Gnarra J R; Duan D R; Weng Y; Humphrey J S; Chen D Y; Lee S; Pause A; Dudley C F; Latif F; Kuzmin I; Schmidt L; Duh F M; Stackhouse T; Chen F; Kishida T; Wei M H; Lerman M I; Zbar B; Klausner R D; Linehan W M
Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal carcinoma.
Biochimica et biophysica acta 1996;1242(3):201-10.
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1996: Stearman R; Yuan D S; Yamaguchi-Iwai Y; Klausner R D; Dancis A
A permease-oxidase complex involved in high-affinity iron uptake in yeast.
Science (New York, N.Y.) 1996;271(5255):1552-7.
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1996: Pause A; Aso T; Linehan W M; Conaway J W; Conaway R C; Klausner R D
Interaction of von Hippel-Lindau tumor suppressor gene product with elongin.
Methods in enzymology 1996;274():436-41.
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1996: Rouault T A; Klausner R D
The impact of oxidative stress on eukaryotic iron metabolism.
EXS 1996;77():183-97.
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1995: Iwai K; Klausner R D; Rouault T A
Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2.
The EMBO journal 1995;14(21):5350-7.
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1995: Duan D R; Pause A; Burgess W H; Aso T; Chen D Y; Garrett K P; Conaway R C; Conaway J W; Linehan W M; Klausner R D
Inhibition of transcription elongation by the VHL tumor suppressor protein.
Science (New York, N.Y.) 1995;269(5229):1402-6.
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1995: Duan D R; Humphrey J S; Chen D Y; Weng Y; Sukegawa J; Lee S; Gnarra J R; Linehan W M; Klausner R D
Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(14):6459-63.
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1995: DeRusso P A; Philpott C C; Iwai K; Mostowski H S; Klausner R D; Rouault T A
Expression of a constitutive mutant of iron regulatory protein 1 abolishes iron homeostasis in mammalian cells.
The Journal of biological chemistry 1995;270(26):15451-4.
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1995: Peters P J; Hsu V W; Ooi C E; Finazzi D; Teal S B; Oorschot V; Donaldson J G; Klausner R D
Overexpression of wild-type and mutant ARF1 and ARF6: distinct perturbations of nonoverlapping membrane compartments.
The Journal of cell biology 1995;128(6):1003-17.
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1995: Kim H Y; Klausner R D; Rouault T A
Translational repressor activity is equivalent and is quantitatively predicted by in vitro RNA binding for two iron-responsive element-binding proteins, IRP1 and IRP2.
The Journal of biological chemistry 1995;270(10):4983-6.
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1995: Yamaguchi-Iwai Y; Dancis A; Klausner R D
AFT1: a mediator of iron regulated transcriptional control in Saccharomyces cerevisiae.
The EMBO journal 1995;14(6):1231-9.
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1995: Yuan D S; Stearman R; Dancis A; Dunn T; Beeler T; Klausner R D
The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2632-6.
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1994: Samaniego F; Chin J; Iwai K; Rouault T A; Klausner R D
Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation.
The Journal of biological chemistry 1994;269(49):30904-10.
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1994: Klausner R D; Dancis A
A genetic approach to elucidating eukaryotic iron metabolism.
FEBS letters 1994;355(2):109-13.
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1994: Dancis A; Haile D; Yuan D S; Klausner R D
The Saccharomyces cerevisiae copper transport protein (Ctr1p). Biochemical characterization, regulation by copper, and physiologic role in copper uptake.
The Journal of biological chemistry 1994;269(41):25660-7.
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1994: Donaldson J G; Klausner R D
ARF: a key regulatory switch in membrane traffic and organelle structure.
Current opinion in cell biology 1994;6(4):527-32.
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1994: Philpott C C; Klausner R D; Rouault T A
The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):7321-5.
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1994: Basilion J P; Kennedy M C; Beinert H; Massinople C M; Klausner R D; Rouault T A
Overexpression of iron-responsive element-binding protein and its analytical characterization as the RNA-binding form, devoid of an iron-sulfur cluster.
Archives of biochemistry and biophysics 1994;311(2):517-22.
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1994: Finazzi D; Cassel D; Donaldson J G; Klausner R D
Aluminum fluoride acts on the reversibility of ARF1-dependent coat protein binding to Golgi membranes.
The Journal of biological chemistry 1994;269(18):13325-30.
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1994: Binder R; Horowitz J A; Basilion J P; Koeller D M; Klausner R D; Harford J B
Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3' UTR and does not involve poly(A) tail shortening.
The EMBO journal 1994;13(8):1969-80.
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1994: Teal S B; Hsu V W; Peters P J; Klausner R D; Donaldson J G
An activating mutation in ARF1 stabilizes coatomer binding to Golgi membranes.
The Journal of biological chemistry 1994;269(5):3135-8.
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1994: Dancis A; Yuan D S; Haile D; Askwith C; Eide D; Moehle C; Kaplan J; Klausner R D
Molecular characterization of a copper transport protein in S. cerevisiae: an unexpected role for copper in iron transport.
Cell 1994;76(2):393-402.
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1994: Basilion J P; Rouault T A; Massinople C M; Klausner R D; Burgess W H
The iron-responsive element-binding protein: localization of the RNA-binding site to the aconitase active-site cleft.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(2):574-8.
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1994: Anderson G J; Dancis A; Roman D G; Klausner R D
Ferric iron reduction and iron uptake in eucaryotes: studies with the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe.
Advances in experimental medicine and biology 1994;356():81-9.
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1993: Jaffrey S R; Haile D J; Klausner R D; Harford J B
The interaction between the iron-responsive element binding protein and its cognate RNA is highly dependent upon both RNA sequence and structure.
Nucleic acids research 1993;21(19):4627-31.
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1993: Philpott C C; Haile D; Rouault T A; Klausner R D
Modification of a free Fe-S cluster cysteine residue in the active iron-responsive element-binding protein prevents RNA binding.
The Journal of biological chemistry 1993;268(24):17655-8.
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1993: Roman D G; Dancis A; Anderson G J; Klausner R D
The fission yeast ferric reductase gene frp1+ is required for ferric iron uptake and encodes a protein that is homologous to the gp91-phox subunit of the human NADPH phagocyte oxidoreductase.
Molecular and cellular biology 1993;13(7):4342-50.
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1993: Shah N; Klausner R D
Brefeldin A reversibly inhibits secretion in Saccharomyces cerevisiae.
The Journal of biological chemistry 1993;268(8):5345-8.
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1993: Lankford S P; Cosson P; Bonifacino J S; Klausner R D
Transmembrane domain length affects charge-mediated retention and degradation of proteins within the endoplasmic reticulum.
The Journal of biological chemistry 1993;268(7):4814-20.
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1993: Klausner R D; Rouault T A
A double life: cytosolic aconitase as a regulatory RNA binding protein.
Molecular biology of the cell 1993;4(1):1-5.
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1993: Klausner R D; Rouault T A; Harford J B
Regulating the fate of mRNA: the control of cellular iron metabolism.
Cell 1993;72(1):19-28.
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1992: Samelson L E; Klausner R D
Tyrosine kinases and tyrosine-based activation motifs. Current research on activation via the T cell antigen receptor.
The Journal of biological chemistry 1992;267(35):24913-6.
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1992: Tang C K; Chin J; Harford J B; Klausner R D; Rouault T A
Iron regulates the activity of the iron-responsive element binding protein without changing its rate of synthesis or degradation.
The Journal of biological chemistry 1992;267(34):24466-70.
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1992: Haile D J; Rouault T A; Harford J B; Kennedy M C; Blondin G A; Beinert H; Klausner R D
Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high-affinity RNA binding.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(24):11735-9.
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1992: Donaldson J G; Finazzi D; Klausner R D
Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein.
Nature 1992;360(6402):350-2.
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1992: Rutledge T; Cosson P; Manolios N; Bonifacino J S; Klausner R D
Transmembrane helical interactions: zeta chain dimerization and functional association with the T cell antigen receptor.
The EMBO journal 1992;11(9):3245-54.
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1992: Haile D J; Rouault T A; Tang C K; Chin J; Harford J B; Klausner R D
Reciprocal control of RNA-binding and aconitase activity in the regulation of the iron-responsive element binding protein: role of the iron-sulfur cluster.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7536-40.
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1992: Anderson G J; Lesuisse E; Dancis A; Roman D G; Labbe P; Klausner R D
Ferric iron reduction and iron assimilation in Saccharomyces cerevisiae.
Journal of inorganic biochemistry 1992;47(3-4):249-55.
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1992: McBride A A; Klausner R D; Howley P M
Conserved cysteine residue in the DNA-binding domain of the bovine papillomavirus type 1 E2 protein confers redox regulation of the DNA-binding activity in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7531-5.
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1992: Donaldson J G; Cassel D; Kahn R A; Klausner R D
ADP-ribosylation factor, a small GTP-binding protein, is required for binding of the coatomer protein beta-COP to Golgi membranes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6408-12.
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1992: Letourneur F; Klausner R D
A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains.
Cell 1992;69(7):1143-57.
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1992: Engel I; Ottenhoff T H; Klausner R D
High-efficiency expression and solubilization of functional T cell antigen receptor heterodimers.
Science (New York, N.Y.) 1992;256(5061):1318-21.
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1992: Dancis A; Roman D G; Anderson G J; Hinnebusch A G; Klausner R D
Ferric reductase of Saccharomyces cerevisiae: molecular characterization, role in iron uptake, and transcriptional control by iron.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(9):3869-73.
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1992: Hsu V W; Shah N; Klausner R D
A brefeldin A-like phenotype is induced by the overexpression of a human ERD-2-like protein, ELP-1.
Cell 1992;69(4):625-35.
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1992: Klausner R D; Donaldson J G; Lippincott-Schwartz J
Brefeldin A: insights into the control of membrane traffic and organelle structure.
The Journal of cell biology 1992;116(5):1071-80.
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1992: Hsu V W; Klausner R D; Fine J S; Kruisbeek A M; Baniyash M
Changes in the methylation pattern of the TCR zeta-chain gene correlate with its expression in T cells and developing thymocytes.
The New biologist 1992;4(2):166-71.
-
1992: Letourneur F; Klausner R D
Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon.
Science (New York, N.Y.) 1992;255(5040):79-82.
-
1992: Engel I; Letourneur F; Houston J T; Ottenhoff T H; Klausner R D
T cell receptor structure and function: analysis by expression of portions of isolated subunits.
Advances in experimental medicine and biology 1992;323():1-7.
-
1991: Donaldson J G; Kahn R A; Lippincott-Schwartz J; Klausner R D
Binding of ARF and beta-COP to Golgi membranes: possible regulation by a trimeric G protein.
Science (New York, N.Y.) 1991;254(5035):1197-9.
-
1991: Philpott C C; Rouault T A; Klausner R D
Sequence and expression of the murine iron-responsive element binding protein.
Nucleic acids research 1991;19(22):6333.
-
1991: Kaptain S; Downey W E; Tang C; Philpott C; Haile D; Orloff D G; Harford J B; Rouault T A; Klausner R D
A regulated RNA binding protein also possesses aconitase activity.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(22):10109-13.
-
1991: Lippincott-Schwartz J; Yuan L; Tipper C; Amherdt M; Orci L; Klausner R D
Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic.
Cell 1991;67(3):601-16.
-
1991: Bonifacino J S; Cosson P; Shah N; Klausner R D
Role of potentially charged transmembrane residues in targeting proteins for retention and degradation within the endoplasmic reticulum.
The EMBO journal 1991;10(10):2783-93.
-
1991: Letourneur F; Klausner R D
T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(20):8905-9.
-
1991: Koeller D M; Horowitz J A; Casey J L; Klausner R D; Harford J B
Translation and the stability of mRNAs encoding the transferrin receptor and c-fos.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(17):7778-82.
-
1991: Hsu V W; Yuan L C; Nuchtern J G; Lippincott-Schwartz J; Hammerling G J; Klausner R D
A recycling pathway between the endoplasmic reticulum and the Golgi apparatus for retention of unassembled MHC class I molecules.
Nature 1991;352(6334):441-4.
-
1991: Manolios N; Letourneur F; Bonifacino J S; Klausner R D
Pairwise, cooperative and inhibitory interactions describe the assembly and probable structure of the T-cell antigen receptor.
The EMBO journal 1991;10(7):1643-51.
-
1991: Suzuki C K; Bonifacino J S; Lin A Y; Davis M M; Klausner R D
Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP.
The Journal of cell biology 1991;114(2):189-205.
-
1991: Minami Y; Stafford F J; Lippincott-Schwartz J; Yuan L C; Klausner R D
Novel redistribution of an intracellular pool of CD45 accompanies T cell activation.
The Journal of biological chemistry 1991;266(14):9222-30.
-
1991: Cosson P; Lankford S P; Bonifacino J S; Klausner R D
Membrane protein association by potential intramembrane charge pairs.
Nature 1991;351(6325):414-6.
-
1991: Rouault T A; Stout C D; Kaptain S; Harford J B; Klausner R D
Structural relationship between an iron-regulated RNA-binding protein (IRE-BP) and aconitase: functional implications.
Cell 1991;64(5):881-3.
-
1991: Klausner R D; Samelson L E
T cell antigen receptor activation pathways: the tyrosine kinase connection.
Cell 1991;64(5):875-8.
-
1991: Donaldson J G; Lippincott-Schwartz J; Klausner R D
Guanine nucleotides modulate the effects of brefeldin A in semipermeable cells: regulation of the association of a 110-kD peripheral membrane protein with the Golgi apparatus.
The Journal of cell biology 1991;112(4):579-88.
-
1991: Lippincott-Schwartz J; Glickman J; Donaldson J G; Robbins J; Kreis T E; Seamon K B; Sheetz M P; Klausner R D
Forskolin inhibits and reverses the effects of brefeldin A on Golgi morphology by a cAMP-independent mechanism.
The Journal of cell biology 1991;112(4):567-77.
-
1990: Donaldson J G; Lippincott-Schwartz J; Bloom G S; Kreis T E; Klausner R D
Dissociation of a 110-kD peripheral membrane protein from the Golgi apparatus is an early event in brefeldin A action.
The Journal of cell biology 1990;111(6 Pt 1):2295-306.
-
1990: Garcia-Morales P; Minami Y; Luong E; Klausner R D; Samelson L E
Tyrosine phosphorylation in T cells is regulated by phosphatase activity: studies with phenylarsine oxide.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(23):9255-9.
-
1990: Goossen B; Caughman S W; Harford J B; Klausner R D; Hentze M W
Translational repression by a complex between the iron-responsive element of ferritin mRNA and its specific cytoplasmic binding protein is position-dependent in vivo.
The EMBO journal 1990;9(12):4127-33.
-
1990: Bonifacino J S; Cosson P; Klausner R D
Colocalized transmembrane determinants for ER degradation and subunit assembly explain the intracellular fate of TCR chains.
Cell 1990;63(3):503-13.
-
1990: Rouault T A; Tang C K; Kaptain S; Burgess W H; Haile D J; Samaniego F; McBride O W; Harford J B; Klausner R D
Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(20):7958-62.
-
1990: Orloff D G; Ra C S; Frank S J; Klausner R D; Kinet J P
Family of disulphide-linked dimers containing the zeta and eta chains of the T-cell receptor and the gamma chain of Fc receptors.
Nature 1990;347(6289):189-91.
-
1990: Haile D J; Rouault T A; Harford J B; Klausner R D
The inhibition of the iron responsive element RNA-protein interaction by heme does not mimic in vivo iron regulation.
The Journal of biological chemistry 1990;265(22):12786-9.
-
1990: Klausner R D; Sitia R
Protein degradation in the endoplasmic reticulum.
Cell 1990;62(4):611-4.
-
1990: Antusch D; Bonifacino J S; Burgess W H; Klausner R D
The T cell receptor-associated protein is proteolytically cleaved in a pre-Golgi compartment.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(3):885-90.
-
1990: Frank S J; Niklinska B B; Orloff D G; Mercep M; Ashwell J D; Klausner R D
Structural mutations of the T cell receptor zeta chain and its role in T cell activation.
Science (New York, N.Y.) 1990;249(4965):174-7.
-
1990: Manolios N; Bonifacino J S; Klausner R D
Transmembrane helical interactions and the assembly of the T cell receptor complex.
Science (New York, N.Y.) 1990;249(4966):274-7.
-
1990: Samelson L E; Phillips A F; Luong E T; Klausner R D
Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(11):4358-62.
-
1990: Dancis A; Klausner R D; Hinnebusch A G; Barriocanal J G
Genetic evidence that ferric reductase is required for iron uptake in Saccharomyces cerevisiae.
Molecular and cellular biology 1990;10(5):2294-301.
-
1990: Nakhasi H L; Rouault T A; Haile D J; Liu T Y; Klausner R D
Specific high-affinity binding of host cell proteins to the 3' region of rubella virus RNA.
The New biologist 1990;2(3):255-64.
-
1990: Lippincott-Schwartz J; Donaldson J G; Schweizer A; Berger E G; Hauri H P; Yuan L C; Klausner R D
Microtubule-dependent retrograde transport of proteins into the ER in the presence of brefeldin A suggests an ER recycling pathway.
Cell 1990;60(5):821-36.
-
1990: Frank S J; Samelson L E; Klausner R D
The structure and signalling functions of the invariant T cell receptor components.
Seminars in immunology 1990;2(2):89-97.
-
1990: Bonifacino J S; McCarthy S A; Maguire J E; Nakayama T; Singer D S; Klausner R D; Singer A
Novel post-translational regulation of TCR expression in CD4+CD8+ thymocytes influenced by CD4.
Nature 1990;344(6263):247-51.
-
1990: Bonifacino J S; Suzuki C K; Klausner R D
A peptide sequence confers retention and rapid degradation in the endoplasmic reticulum.
Science (New York, N.Y.) 1990;247(4938):79-82.
-
1990: Nuchtern J G; Biddison W E; Klausner R D
Class II MHC molecules can use the endogenous pathway of antigen presentation.
Nature 1990;343(6253):74-6.
-
1990: Harford J B; Klausner R D
Coordinate post-transcriptional regulation of ferritin and transferrin receptor expression: the role of regulated RNA-protein interaction.
Enzyme 1990;44(1-4):28-41.
-
1989: Casey J L; Koeller D M; Ramin V C; Klausner R D; Harford J B
Iron regulation of transferrin receptor mRNA levels requires iron-responsive elements and a rapid turnover determinant in the 3' untranslated region of the mRNA.
The EMBO journal 1989;8(12):3693-9.
-
1989: Weissman A M; Frank S J; Orloff D G; Mercep M; Ashwell J D; Klausner R D
Role of the zeta chain in the expression of the T cell antigen receptor: genetic reconstitution studies.
The EMBO journal 1989;8(12):3651-6.
-
1989: Mercep M; Weissman A M; Frank S J; Klausner R D; Ashwell J D
Activation-driven programmed cell death and T cell receptor zeta eta expression.
Science (New York, N.Y.) 1989;246(4934):1162-5.
-
1989: Klausner R D; Harford J B
cis-trans models for post-transcriptional gene regulation.
Science (New York, N.Y.) 1989;246(4932):870-2.
-
1989: Haile D J; Hentze M W; Rouault T A; Harford J B; Klausner R D
Regulation of interaction of the iron-responsive element binding protein with iron-responsive RNA elements.
Molecular and cellular biology 1989;9(11):5055-61.
-
1989: Klausner R D
Architectural editing: determining the fate of newly synthesized membrane proteins.
The New biologist 1989;1(1):3-8.
-
1989: Orloff D G; Frank S J; Robey F A; Weissman A M; Klausner R D
Biochemical characterization of the eta chain of the T-cell receptor. A unique subunit related to zeta.
The Journal of biological chemistry 1989;264(25):14812-7.
-
1989: Baniyash M; Hsu V W; Seldin M F; Klausner R D
The isolation and characterization of the murine T cell antigen receptor zeta chain gene.
The Journal of biological chemistry 1989;264(22):13252-7.
-
1989: Hentze M W; Seuanez H N; O'Brien S J; Harford J B; Klausner R D
Chromosomal localization of nucleic acid-binding proteins by affinity mapping: assignment of the IRE-binding protein gene to human chromosome 9.
Nucleic acids research 1989;17(15):6103-8.
-
1989: Rouault T A; Hentze M W; Haile D J; Harford J B; Klausner R D
The iron-responsive element binding protein: a method for the affinity purification of a regulatory RNA-binding protein.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(15):5768-72.
-
1989: Bonifacino J S; Suzuki C K; Lippincott-Schwartz J; Weissman A M; Klausner R D
Pre-Golgi degradation of newly synthesized T-cell antigen receptor chains: intrinsic sensitivity and the role of subunit assembly.
The Journal of cell biology 1989;109(1):73-83.
-
1989: Hsi E D; Siegel J N; Minami Y; Luong E T; Klausner R D; Samelson L E
T cell activation induces rapid tyrosine phosphorylation of a limited number of cellular substrates.
The Journal of biological chemistry 1989;264(18):10836-42.
-
1989: Klausner R D
Sorting and traffic in the central vacuolar system.
Cell 1989;57(5):703-6.
-
1989: Nuchtern J G; Bonifacino J S; Biddison W E; Klausner R D
Brefeldin A implicates egress from endoplasmic reticulum in class I restricted antigen presentation.
Nature 1989;339(6221):223-6.
-
1989: Koeller D M; Casey J L; Hentze M W; Gerhardt E M; Chan L N; Klausner R D; Harford J B
A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(10):3574-8.
-
1989: Hentze M W; Rouault T A; Harford J B; Klausner R D
Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction.
Science (New York, N.Y.) 1989;244(4902):357-9.
-
1989: Lippincott-Schwartz J; Yuan L C; Bonifacino J S; Klausner R D
Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER.
Cell 1989;56(5):801-13.
-
1989: Klausner R D; Weissman A M; Baniyash M; Bonifacino J S; Samelson L E
The role of the zeta chain in the expression, structure and function of the T cell receptor.
Advances in experimental medicine and biology 1989;254():21-4.
-
1989: Weissman A M; Bonifacino J S; Klausner R D; Samelson L E; O'Shea J J
T cell antigen receptor: structure, assembly and function.
The Year in immunology 1989;4():74-93.
-
1988: Hentze M W; Caughman S W; Casey J L; Koeller D M; Rouault T A; Harford J B; Klausner R D
A model for the structure and functions of iron-responsive elements.
Gene 1988;72(1-2):201-8.
-
1988: Caughman S W; Hentze M W; Rouault T A; Harford J B; Klausner R D
The iron-responsive element is the single element responsible for iron-dependent translational regulation of ferritin biosynthesis. Evidence for function as the binding site for a translational repressor.
The Journal of biological chemistry 1988;263(35):19048-52.
-
1988: Baniyash M; Garcia-Morales P; Luong E; Samelson L E; Klausner R D
The T cell antigen receptor zeta chain is tyrosine phosphorylated upon activation.
The Journal of biological chemistry 1988;263(34):18225-30.
-
1988: Weissman A M; Hou D; Orloff D G; Modi W S; Seuanez H; O'Brien S J; Klausner R D
Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(24):9709-13.
-
1988: Chen C; Bonifacino J S; Yuan L C; Klausner R D
Selective degradation of T cell antigen receptor chains retained in a pre-Golgi compartment.
The Journal of cell biology 1988;107(6 Pt 1):2149-61.
-
1988: Weissman A M; Ross P; Luong E T; Garcia-Morales P; Jelachich M L; Biddison W E; Klausner R D; Samelson L E
Tyrosine phosphorylation of the human T cell antigen receptor zeta-chain: activation via CD3 but not CD2.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(10):3532-6.
-
1988: Mercep M; Bonifacino J S; Garcia-Morales P; Samelson L E; Klausner R D; Ashwell J D
T cell CD3-zeta eta heterodimer expression and coupling to phosphoinositide hydrolysis.
Science (New York, N.Y.) 1988;242(4878):571-4.
-
1988: Rouault T A; Hentze M W; Caughman S W; Harford J B; Klausner R D
Binding of a cytosolic protein to the iron-responsive element of human ferritin messenger RNA.
Science (New York, N.Y.) 1988;241(4870):1207-10.
-
1988: Bonifacino J S; Chen C; Lippincott-Schwartz J; Ashwell J D; Klausner R D
Subunit interactions within the T-cell antigen receptor: clues from the study of partial complexes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(18):6929-33.
-
1988: Kaldjian E; McCarthy S A; Sharrow S O; Littman D R; Klausner R D; Singer A
Nonequivalent effects of PKC activation by PMA on murine CD4 and CD8 cell-surface expression.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1988;2(12):2801-6.
-
1988: Lippincott-Schwartz J; Bonifacino J S; Yuan L C; Klausner R D
Degradation from the endoplasmic reticulum: disposing of newly synthesized proteins.
Cell 1988;54(2):209-20.
-
1988: Baniyash M; Garcia-Morales P; Bonifacino J S; Samelson L E; Klausner R D
Disulfide linkage of the zeta and eta chains of the T cell receptor. Possible identification of two structural classes of receptors.
The Journal of biological chemistry 1988;263(20):9874-8.
-
1988: Bonifacino J S; Lippincott-Schwartz J; Chen C; Antusch D; Samelson L E; Klausner R D
Association and dissociation of the murine T cell receptor associated protein (TRAP). Early events in the biosynthesis of a multisubunit receptor.
The Journal of biological chemistry 1988;263(18):8965-71.
-
1988: Casey J L; Hentze M W; Koeller D M; Caughman S W; Rouault T A; Klausner R D; Harford J B
Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation.
Science (New York, N.Y.) 1988;240(4854):924-8.
-
1988: Casey J L; Di Jeso B; Rao K; Klausner R D; Harford J B
Two genetic loci participate in the regulation by iron of the gene for the human transferrin receptor.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(6):1787-91.
-
1988: Weissman A M; Baniyash M; Hou D; Samelson L E; Burgess W H; Klausner R D
Molecular cloning of the zeta chain of the T cell antigen receptor.
Science (New York, N.Y.) 1988;239(4843):1018-21.
-
1988: Casey J L; Di Jeso B; Rao K K; Rouault T A; Klausner R D; Harford J B
Deletional analysis of the promoter region of the human transferrin receptor gene.
Nucleic acids research 1988;16(2):629-46.
-
1988: Sussman J J; Bonifacino J S; Lippincott-Schwartz J; Weissman A M; Saito T; Klausner R D; Ashwell J D
Failure to synthesize the T cell CD3-zeta chain: structure and function of a partial T cell receptor complex.
Cell 1988;52(1):85-95.
-
1988: Casey J L; Di Jeso B; Rao K; Rouault T A; Klausner R D; Harford J B
The promoter region of the human transferrin receptor gene.
Annals of the New York Academy of Sciences 1988;526():54-64.
-
1988: Samelson L E; Klausner R D
The T-cell antigen receptor. Structure and mechanism of activation.
Annals of the New York Academy of Sciences 1988;540():1-3.
-
1988: Bonifacino J S; Mercep M; Sussman J J; Klausner R D; Ashwell J D
The T-cell antigen receptor: a complex signal-transducing molecule.
Princess Takamatsu symposia 1988;19():87-104.
-
1987: Hentze M W; Caughman S W; Rouault T A; Barriocanal J G; Dancis A; Harford J B; Klausner R D
Identification of the iron-responsive element for the translational regulation of human ferritin mRNA.
Science (New York, N.Y.) 1987;238(4833):1570-3.
-
1987: O'Shea J J; Urdahl K B; Luong H T; Chused T M; Samelson L E; Klausner R D
Aluminum fluoride induces phosphatidylinositol turnover, elevation of cytoplasmic free calcium, and phosphorylation of the T cell antigen receptor in murine T cells.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(10):3463-9.
-
1987: Hentze M W; Rouault T A; Caughman S W; Dancis A; Harford J B; Klausner R D
A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(19):6730-4.
-
1987: Samelson L E; O'Shea J J; Luong H; Ross P; Urdahl K B; Klausner R D; Bluestone J
T cell antigen receptor phosphorylation induced by an anti-receptor antibody.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(8):2708-14.
-
1987: Minami Y; Samelson L E; Klausner R D
Internalization and cycling of the T cell antigen receptor. Role of protein kinase C.
The Journal of biological chemistry 1987;262(27):13342-7.
-
1987: Klausner R D; O'Shea J J; Luong H; Ross P; Bluestone J A; Samelson L E
T cell receptor tyrosine phosphorylation. Variable coupling for different activating ligands.
The Journal of biological chemistry 1987;262(26):12654-9.
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