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Colin Kleanthous

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Escherichia coli

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TOP 3
Oliver E Farrance; Eleanore Hann; Nicholas G Housden; Renata Kaminska; Colin Kleanthous; Sheena E Radford; Sasha R Derrington; David J Brockwell
A force-activated trip switch triggers rapid dissociation of a colicin from its immunity protein.
Christopher N Penfold; Daniel Walker; Colin Kleanthous
How bugs kill bugs: progress and challenges in bacteriocin research.
Justyna Aleksandra Wojdyla; David Baker; Sarel J Fleishman; Colin Kleanthous
Structure of the ultra-high-affinity colicin E2 DNase--Im2 complex.

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All Publications

2013: Oliver E Farrance; Eleanore Hann; Nicholas G Housden; Renata Kaminska; Colin Kleanthous; Sheena E Radford; Sasha R Derrington; David J Brockwell
A force-activated trip switch triggers rapid dissociation of a colicin from its immunity protein.
PLoS biology 2013;11(2):e1001489.
2012: Christopher N Penfold; Daniel Walker; Colin Kleanthous
How bugs kill bugs: progress and challenges in bacteriocin research.
Biochemical Society transactions 2012;40(6):1433-7.
2012: Justyna Aleksandra Wojdyla; David Baker; Sarel J Fleishman; Colin Kleanthous
Structure of the ultra-high-affinity colicin E2 DNase--Im2 complex.
Journal of molecular biology 2012;417(1-2):79-94.
2012: Clare L Pashley; Arnout P Kalverda; Colin Kleanthous; Gareth J Morgan; Gary S Thompson; Sheena E Radford
Conformational properties of the unfolded state of Im7 in nondenaturing conditions.
Journal of molecular biology 2012;416(2):300-18.
2012: Grigorios Papadakos; Justyna A Wojdyla; Colin Kleanthous
Nuclease colicins and their immunity proteins.
Quarterly reviews of biophysics 2012;45(1):57-103.
2011: Nicholas G Housden; Colin Kleanthous
Thermodynamic dissection of colicin interactions.
Methods in enzymology 2011;488():123-45.
2010: Nicholas G Housden; Justyna A Wojdyla; Justyna Korczynska; Irina Grishkovskaya; Nadine Kirkpatrick; Andrzej M Brzozowski; Colin Kleanthous
Directed epitope delivery across the Escherichia coli outer membrane through the porin OmpF.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(50):21412-7.
2010: Colin Kleanthous
Swimming against the tide: progress and challenges in our understanding of colicin translocation.
Nature reviews. Microbiology 2010;8(12):843-8.
2010: C Leong Ng; Kathrin Lang; Nicola A G Meenan; Amit Sharma; Ann C Kelley; Colin Kleanthous; Venki Ramakrishnan
Structural basis for 16S ribosomal RNA cleavage by the cytotoxic domain of colicin E3.
Nature structural & molecular biology 2010;17(10):1241-6.
2010: Anne Marie Krachler; Amit Sharma; Colin Kleanthous
Self-association of TPR domains: Lessons learned from a designed, consensus-based TPR oligomer.
Proteins 2010;78(9):2131-43.
2010: Nicola A G Meenan; Amit Sharma; Sarel J Fleishman; Colin J Macdonald; Bertrand Morel; Ruth Boetzel; Geoffrey R Moore; David Baker; Colin Kleanthous
The structural and energetic basis for high selectivity in a high-affinity protein-protein interaction.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(22):10080-5.
2010: Colin Kleanthous
Translocator hunt comes full Cir-Col.
Molecular microbiology 2010;75(3):529-33.
2009: Daniel A Bonsor; Oliver Hecht; Mireille Vankemmelbeke; Amit Sharma; Anne Marie Krachler; Nicholas G Housden; Katie J Lilly; Richard James; Geoffrey R Moore; Colin Kleanthous
Allosteric beta-propeller signalling in TolB and its manipulation by translocating colicins.
The EMBO journal 2009;28(18):2846-57.
2009: Mireille Vankemmelbeke; Ying Zhang; Geoffrey R Moore; Colin Kleanthous; Christopher N Penfold; Richard James
Energy-dependent immunity protein release during tol-dependent nuclease colicin translocation.
The Journal of biological chemistry 2009;284(28):18932-41.
2008: Daniel A Bonsor; Nicola A Meenan; Colin Kleanthous
Colicins exploit native disorder to gain cell entry: a hitchhiker's guide to translocation.
Biochemical Society transactions 2008;36(Pt 6):1409-13.
2008: Lorna E Lancaster; Andreas Savelsbergh; Colin Kleanthous; Wolfgang Wintermeyer; Marina V Rodnina
Colicin E3 cleavage of 16S rRNA impairs decoding and accelerates tRNA translocation on Escherichia coli ribosomes.
Molecular microbiology 2008;69(2):390-401.
2008: Anthony H Keeble; Lukasz A Joachimiak; María Jesus Maté; Nicola Meenan; Nadine Kirkpatrick; David Baker; Colin Kleanthous
Experimental and computational analyses of the energetic basis for dual recognition of immunity proteins by colicin endonucleases.
Journal of molecular biology 2008;379(4):745-59.
2008: Adam M Cartwright; Eng-Kiat Lim; Colin Kleanthous; Dianna J Bowles
A kinetic analysis of regiospecific glucosylation by two glycosyltransferases of Arabidopsis thaliana: domain swapping to introduce new activities.
The Journal of biological chemistry 2008;283(23):15724-31.
2007: Marta Botër; Béatrice Amigues; Jack Peart; Christian Breuer; Yasuhiro Kadota; Catarina Casais; Geoffrey Moore; Colin Kleanthous; Francoise Ochsenbein; Ken Shirasu; raphael guerois
Structural and functional analysis of SGT1 reveals that its interaction with HSP90 is required for the accumulation of Rx, an R protein involved in plant immunity.
The Plant cell 2007;19(11):3791-804.
2007: Daniel Walker; Khédidja Mosbahi; Mireille Vankemmelbeke; Richard James; Colin Kleanthous
The role of electrostatics in colicin nuclease domain translocation into bacterial cells.
The Journal of biological chemistry 2007;282(43):31389-97.
2007: Afua Nyarko; Khédidja Mosbahi; Arthur J Rowe; Andrew P Leech; Marta Boter; Ken Shirasu; Colin Kleanthous
TPR-Mediated self-association of plant SGT1.
Biochemistry 2007;46(40):11331-41.
2007: Eleanore Hann; Nadine Kirkpatrick; Colin Kleanthous; D Alastair Smith; Sheena E Radford; David J Brockwell
The effect of protein complexation on the mechanical stability of Im9.
Biophysical journal 2007;92(9):L79-81.
2007: Daniel A Bonsor; Irina Grishkovskaya; Eleanor J Dodson; Colin Kleanthous
Molecular mimicry enables competitive recruitment by a natively disordered protein.
Journal of the American Chemical Society 2007;129(15):4800-7.
2007: Gaye F White; L Ottignon; Theonie Georgiou; Colin Kleanthous; Geoffrey R Moore; Andrew J Thomson; Vasily S Oganesyan
Analysis of nitroxide spin label motion in a protein-protein complex using multiple frequency EPR spectroscopy.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2007;185(2):191-203.
2007: Charles T Heise; Cécile S Le Duff; Marta Boter; Catarina Casais; Joanne E Airey; Andrew P Leech; Béatrice Amigues; raphael guerois; Geoffrey R Moore; Ken Shirasu; Colin Kleanthous
Biochemical characterization of RAR1 cysteine- and histidine-rich domains (CHORDs): a novel class of zinc-dependent protein-protein interaction modules.
Biochemistry 2007;46(6):1612-23.
2006: Steven R Loftus; Daniel Walker; Maria J Maté; Daniel A Bonsor; Richard James; Geoffrey R Moore; Colin Kleanthous
Competitive recruitment of the periplasmic translocation portal TolB by a natively disordered domain of colicin E9.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(33):12353-8.
2006: Konrad Zdanowski; Phillip Doughty; Piotr Jakimowicz; Liisa O'Hara; Mark J Buttner; Mark S B Paget; Colin Kleanthous
Assignment of the zinc ligands in RsrA, a redox-sensing ZAS protein from Streptomyces coelicolor.
Biochemistry 2006;45(27):8294-300.
2006: Anthony H Keeble; Nadine Kirkpatrick; Seishi Shimizu; Colin Kleanthous
Calorimetric dissection of colicin DNase--immunity protein complex specificity.
Biochemistry 2006;45(10):3243-54.
2006: Khédidja Mosbahi; Daniel Walker; Richard James; Geoffrey R Moore; Colin Kleanthous
Global structural rearrangement of the cell penetrating ribonuclease colicin E3 on interaction with phospholipid membranes.
Protein science : a publication of the Protein Society 2006;15(3):620-7.
2005: Nicholas G Housden; Steven R Loftus; Geoffrey R Moore; Richard James; Colin Kleanthous
Cell entry mechanism of enzymatic bacterial colicins: porin recruitment and the thermodynamics of receptor binding.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(39):13849-54.
2005: Anthony H Keeble; Colin Kleanthous
The kinetic basis for dual recognition in colicin endonuclease-immunity protein complexes.
Journal of molecular biology 2005;352(3):656-71.
2005: Kaeko Tozawa; Colin J Macdonald; Christopher N Penfold; Richard James; Colin Kleanthous; Nigel J Clayden; Geoffrey R Moore
Clusters in an intrinsically disordered protein create a protein-binding site: the TolB-binding region of colicin E9.
Biochemistry 2005;44(34):11496-507.
2005: Mireille Vankemmelbeke; Bryan Healy; Geoffrey R Moore; Colin Kleanthous; Christopher N Penfold; Richard James
Rapid detection of colicin E9-induced DNA damage using Escherichia coli cells carrying SOS promoter-lux fusions.
Journal of bacteriology 2005;187(14):4900-7.
2005: Ewald T J van den Bremer; Anthony H Keeble; Colin Kleanthous; albert heck
Metal induced selectivity in phosphate ion binding in E9 DNase.
Chemical communications (Cambridge, England) 2005;(9):1137-9.
2005: Nikki A Copeland; Colin Kleanthous
The role of an activating peptide in protease-mediated suicide of Escherichia coli K12.
The Journal of biological chemistry 2005;280(1):112-7.
2005: Robert H H van den Heuvel; Sara Gato; Cees Versluis; Pascal Gerbaux; Colin Kleanthous; albert heck
Real-time monitoring of enzymatic DNA hydrolysis by electrospray ionization mass spectrometry.
Nucleic acids research 2005;33(10):e96.
2004: Colin J Macdonald; Kaeko Tozawa; Emily Collins; Christopher N Penfold; Richard James; Colin Kleanthous; Nigel J Clayden; Geoffrey R Moore
Characterisation of a mobile protein-binding epitope in the translocation domain of colicin E9.
Journal of biomolecular NMR 2004;30(1):81-96.
2004: María J Maté; Colin Kleanthous
Structure-based analysis of the metal-dependent mechanism of H-N-H endonucleases.
The Journal of biological chemistry 2004;279(33):34763-9.
2004: Christopher N Penfold; Bryan Healy; Nicholas G Housden; Ruth Boetzel; Mireille Vankemmelbeke; Geoffrey R Moore; Colin Kleanthous; Richard James
Flexibility in the receptor-binding domain of the enzymatic colicin E9 is required for toxicity against Escherichia coli cells.
Journal of bacteriology 2004;186(14):4520-7.
2004: Nikki A Copeland; Ryan Bingham; Theonie Georgiou; Peter Cooper; Colin Kleanthous
Identification of essential residues within Lit, a cell death peptidase of Escherichia coli K-12.
Biochemistry 2004;43(24):7948-53.
2004: Daniel Walker; Lorna Lancaster; Richard James; Colin Kleanthous
Identification of the catalytic motif of the microbial ribosome inactivating cytotoxin colicin E3.
Protein science : a publication of the Protein Society 2004;13(6):1603-11.
2004: Khédidja Mosbahi; Daniel Walker; Edward J A Lea; Geoffrey R Moore; Richard James; Colin Kleanthous
Destabilization of the colicin E9 Endonuclease domain by interaction with negatively charged phospholipids: implications for colicin translocation into bacteria.
The Journal of biological chemistry 2004;279(21):22145-51.
2004: Ewald T J van den Bremer; Anthony H Keeble; Wim Jiskoot; Robin E J Spelbrink; Claudia S Maier; Arie van Hoek; Antonie J W G Visser; Richard James; Geoffrey R Moore; Colin Kleanthous; albert heck
Distinct conformational stability and functional activity of four highly homologous endonuclease colicins.
Protein science : a publication of the Protein Society 2004;13(5):1391-401.
2004: Ewald T J van den Bremer; Anthony H Keeble; Antonie J W G Visser; Arie van Hoek; Colin Kleanthous; albert heck; Wim Jiskoot
Ligand-induced changes in the conformational dynamics of a bacterial cytotoxic endonuclease.
Biochemistry 2004;43(14):4347-55.
2004: Wei Li; Anthony H Keeble; Catriona Giffard; Richard James; Geoffrey R Moore; Colin Kleanthous
Highly discriminating protein-protein interaction specificities in the context of a conserved binding energy hotspot.
Journal of molecular biology 2004;337(3):743-59.
2004: Daniel Walker; Matthew Rolfe; Arthur Thompson; Geoffrey R Moore; Richard James; Jay Hinton; Colin Kleanthous
Transcriptional profiling of colicin-induced cell death of Escherichia coli MG1655 identifies potential mechanisms by which bacteriocins promote bacterial diversity.
Journal of bacteriology 2004;186(3):866-9.
2003: Wei Li; Andrew Bottrill; Maureen J Bibb; Mark J Buttner; Mark S B Paget; Colin Kleanthous
The Role of zinc in the disulphide stress-regulated anti-sigma factor RsrA from Streptomyces coelicolor.
Journal of molecular biology 2003;333(2):461-72.
2003: Christopher J Law; Christopher N Penfold; Daniel C Walker; Geoffrey R Moore; Richard James; Colin Kleanthous
OmpF enhances the ability of BtuB to protect susceptible Escherichia coli cells from colicin E9 cytotoxicity.
FEBS letters 2003;545(2-3):127-32.
2003: Daniel Walker; Geoffrey R Moore; Richard James; Colin Kleanthous
Thermodynamic consequences of bipartite immunity protein binding to the ribosomal ribonuclease colicin E3.
Biochemistry 2003;42(14):4161-71.
2003: Ruth Boetzel; Emily Collins; Nigel J Clayden; Colin Kleanthous; Richard James; Geoffrey R Moore
Structural dynamics of the receptor-binding domain of colicin E9.
Faraday discussions 2003;122():145-62; discussion 171-90.
2002: Wei Li; Clare Stevenson; Nicolas Burton; Piotr Jakimowicz; Mark S B Paget; Mark J Buttner; David M Lawson; Colin Kleanthous
Identification and structure of the anti-sigma factor-binding domain of the disulphide-stress regulated sigma factor sigma(R) from Streptomyces coelicolor.
Journal of molecular biology 2002;323(2):225-36.
2002: Anthony H Keeble; Andrew M Hemmings; Richard James; Geoffrey R Moore; Colin Kleanthous
Multistep binding of transition metals to the H-N-H endonuclease toxin colicin E9.
Biochemistry 2002;41(32):10234-44.
2002: David C Walker; Theonie Georgiou; Ansgar J Pommer; Daniel Walker; Geoffrey R Moore; Colin Kleanthous; Richard James
Mutagenic scan of the H-N-H motif of colicin E9: implications for the mechanistic enzymology of colicins, homing enzymes and apoptotic endonucleases.
Nucleic acids research 2002;30(14):3225-34.
2002: Ewald T J van den Bremer; Wim Jiskoot; Richard James; Geoffrey R Moore; Colin Kleanthous; albert heck; Claudia S Maier
Probing metal ion binding and conformational properties of the colicin E9 endonuclease by electrospray ionization time-of-flight mass spectrometry.
Protein science : a publication of the Protein Society 2002;11(7):1738-52.
2002: Khédidja Mosbahi; Christelle Lemaître; Anthony H Keeble; Hamid Mobasheri; Bertrand Morel; Richard James; Geoffrey R Moore; Edward J A Lea; Colin Kleanthous
The cytotoxic domain of colicin E9 is a channel-forming endonuclease.
Nature structural biology 2002;9(6):476-84.
2002: Emily Collins; Sara B-M Whittaker; Kaeko Tozawa; Colin MacDonald; Ruth Boetzel; Christopher N Penfold; Ann Reilly; Nigel J Clayden; Michael J Osborne; Andrew M Hemmings; Colin Kleanthous; Richard James; Geoffrey R Moore
Structural dynamics of the membrane translocation domain of colicin E9 and its interaction with TolB.
Journal of molecular biology 2002;318(3):787-804.
2002: Olatomirin O Kolade; Stephen B Carr; Ulrike C Kühlmann; Ansgar J Pommer; Colin Kleanthous; Cristina A Bouchcinsky; Andrew M Hemmings
Structural aspects of the inhibition of DNase and rRNase colicins by their immunity proteins.
Biochimie 2002;84(5-6):439-46.
2002: Richard James; Christopher N Penfold; Geoffrey R Moore; Colin Kleanthous
Killing of E coli cells by E group nuclease colicins.
Biochimie 2002;84(5-6):381-9.
2002: Andrew P Capaldi; Colin Kleanthous; Sheena E Radford
Im7 folding mechanism: misfolding on a path to the native state.
Nature structural biology 2002;9(3):209-16.
2001: Ansgar J Pommer; S Cal; Anthony H Keeble; Daniel Walker; S J Evans; Ulrike C Kühlmann; A Cooper; Bernard A Connolly; Andrew M Hemmings; Geoffrey R Moore; Richard James; Colin Kleanthous
Mechanism and cleavage specificity of the H-N-H endonuclease colicin E9.
Journal of molecular biology 2001;314(4):735-49.
2001: Colin Kleanthous; Daniel Walker
Immunity proteins: enzyme inhibitors that avoid the active site.
Trends in biochemical sciences 2001;26(10):624-31.
2001: S A Gorski; Andrew P Capaldi; Colin Kleanthous; Sheena E Radford
Acidic conditions stabilise intermediates populated during the folding of Im7 and Im9.
Journal of molecular biology 2001;312(4):849-63.
2001: N Ferguson; Wei Li; Andrew P Capaldi; Colin Kleanthous; Sheena E Radford
Using chimeric immunity proteins to explore the energy landscape for alpha-helical protein folding.
Journal of molecular biology 2001;307(1):393-405.
2001: Mark S B Paget; Jae-Bum Bae; Mi-Young Hahn; Wei Li; Colin Kleanthous; Jung-Hye Roe; Mark J Buttner
Mutational analysis of RsrA, a zinc-binding anti-sigma factor with a thiol-disulphide redox switch.
Molecular microbiology 2001;39(4):1036-47.
2001: Andrew P Capaldi; M C Ramachandra Shastry; Colin Kleanthous; Heinrich Roder; Sheena E Radford
Ultrarapid mixing experiments reveal that Im7 folds via an on-pathway intermediate.
Nature structural biology 2001;8(1):68-72.
2000: S Carr; Daniel Walker; Richard James; Colin Kleanthous; Andrew M Hemmings
Crystallization of the cytotoxic domain of a ribosome-inactivating colicin in complex with its immunity protein.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 12):1630-3.
2000: Christopher N Penfold; C Garinot-Schneider; Andrew M Hemmings; Geoffrey R Moore; Colin Kleanthous; Richard James
A 76-residue polypeptide of colicin E9 confers receptor specificity and inhibits the growth of vitamin B12-dependent Escherichia coli 113/3 cells.
Molecular microbiology 2000;38(3):639-49.
2000: S Carr; Daniel Walker; Richard James; Colin Kleanthous; Andrew M Hemmings
Inhibition of a ribosome-inactivating ribonuclease: the crystal structure of the cytotoxic domain of colicin E3 in complex with its immunity protein.
Structure (London, England : 1993) 2000;8(9):949-60.
2000: Ruth Boetzel; Michael Czisch; Robert Kaptein; Andrew M Hemmings; Richard James; Colin Kleanthous; Geoffrey R Moore
NMR investigation of the interaction of the inhibitor protein Im9 with its partner DNase.
Protein science : a publication of the Protein Society 2000;9(9):1709-18.
2000: Ulrike C Kühlmann; Ansgar J Pommer; Geoffrey R Moore; Richard James; Colin Kleanthous
Specificity in protein-protein interactions: the structural basis for dual recognition in endonuclease colicin-immunity protein complexes.
Journal of molecular biology 2000;301(5):1163-78.
2000: R Bingham; S I Ekunwe; S Falk; L Snyder; Colin Kleanthous
The major head protein of bacteriophage T4 binds specifically to elongation factor Tu.
The Journal of biological chemistry 2000;275(30):23219-26.
2000: JP Hannan; Sara B-M Whittaker; Andrew M Hemmings; Richard James; Colin Kleanthous; Geoffrey R Moore
NMR studies of metal ion binding to the Zn-finger-like HNH motif of colicin E9.
Journal of inorganic biochemistry 2000;79(1-4):365-70.
2000: Sara B-M Whittaker; Michael Czisch; Rainer Wechselberger; Robert Kaptein; Andrew M Hemmings; Richard James; Colin Kleanthous; Geoffrey R Moore
Slow conformational dynamics of an endonuclease persist in its complex with its natural protein inhibitor.
Protein science : a publication of the Protein Society 2000;9(4):713-20.
1999: Ulrike C Kühlmann; Geoffrey R Moore; Richard James; Colin Kleanthous; Andrew M Hemmings
Structural parsimony in endonuclease active sites: should the number of homing endonuclease families be redefined?
FEBS letters 1999;463(1-2):1-2.
1999: Ansgar J Pommer; Ulrike C Kühlmann; A Cooper; Andrew M Hemmings; Geoffrey R Moore; Richard James; Colin Kleanthous
Homing in on the role of transition metals in the HNH motif of colicin endonucleases.
The Journal of biological chemistry 1999;274(38):27153-60.
1999: JG Kang; Mark S B Paget; Yeong-Jae Seok; Mi-Young Hahn; Jae-Bum Bae; J S Hahn; Colin Kleanthous; Mark J Buttner; Jung-Hye Roe
RsrA, an anti-sigma factor regulated by redox change.
The EMBO journal 1999;18(15):4292-8.
1999: JP Hannan; Sara B-M Whittaker; Sharon L Davy; Ulrike C Kühlmann; Ansgar J Pommer; Andrew M Hemmings; Richard James; Colin Kleanthous; Geoffrey R Moore
NMR study of Ni2+ binding to the H-N-H endonuclease domain of colicin E9.
Protein science : a publication of the Protein Society 1999;8(8):1711-3.
1999: Sara B-M Whittaker; Ruth Boetzel; Colin MacDonald; LY Lian; Richard James; Colin Kleanthous; Geoffrey R Moore
Assignment of 1H, 13C and 15N signals of the DNase domain of colicin E9.
Journal of biomolecular NMR 1999;14(2):201-2.
1999: N Ferguson; Andrew P Capaldi; Richard James; Colin Kleanthous; Sheena E Radford
Rapid folding with and without populated intermediates in the homologous four-helix proteins Im7 and Im9.
Journal of molecular biology 1999;286(5):1597-608.
1999: Colin Kleanthous; Ulrike C Kühlmann; Ansgar J Pommer; N Ferguson; Sheena E Radford; Geoffrey R Moore; Richard James; Andrew M Hemmings
Structural and mechanistic basis of immunity toward endonuclease colicins.
Nature structural biology 1999;6(3):243-52.
1999: Colin Kleanthous; Richard James; Andrew M Hemmings; Geoffrey R Moore
Protein antibiotics and their inhibitors.
Biochemical Society transactions 1999;27(2):63-7.
1999: Barend Kraal; C Lippmann; Colin Kleanthous
Translational regulation by modifications of the elongation factor Tu.
Folia microbiologica 1999;44(2):131-41.
1999: Ulrike C Kühlmann; Colin Kleanthous; Richard James; Geoffrey R Moore; Andrew M Hemmings
Preliminary X-ray crystallographic analysis of the complex between the DNAase domain of colicin E9 and its cognate immunity protein.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 1):256-9.
1998: Ruth Boetzel; Michael Czisch; Colin J Macdonald; Robert Kaptein; Andrew M Hemmings; Richard James; Colin Kleanthous; Geoffrey R Moore
Assignment of 1H, 13C and 15N signals of the inhibitor protein Im9 bound to the DNase domain of colicin E9.
Journal of biomolecular NMR 1998;12(4):567-8.
1998: Ansgar J Pommer; R Wallis; Geoffrey R Moore; Richard James; Colin Kleanthous
Enzymological characterization of the nuclease domain from the bacterial toxin colicin E9 from Escherichia coli.
The Biochemical journal 1998;334 ( Pt 2)():387-92.
1998: Wei Li; S J Hamill; Andrew M Hemmings; Geoffrey R Moore; Richard James; Colin Kleanthous
Dual recognition and the role of specificity-determining residues in colicin E9 DNase-immunity protein interactions.
Biochemistry 1998;37(34):11771-9.
1998: Sara B-M Whittaker; Ruth Boetzel; Colin MacDonald; LY Lian; Ansgar J Pommer; Ann Reilly; Richard James; Colin Kleanthous; Geoffrey R Moore
NMR detection of slow conformational dynamics in an endonuclease toxin.
Journal of biomolecular NMR 1998;12(1):145-59.
1998: Caitriona Dennis; H Videler; Richard A Pauptit; R Wallis; Richard James; Geoffrey R Moore; Colin Kleanthous
A structural comparison of the colicin immunity proteins Im7 and Im9 gives new insights into the molecular determinants of immunity-protein specificity.
The Biochemical journal 1998;333 ( Pt 1)():183-91.
1998: Andrew P Leech; Ruth Boetzel; C McDonald; Annette K Shrive; Geoffrey R Moore; John R Coggins; Lindsay Sawyer; Colin Kleanthous
Re-evaluating the role of His-143 in the mechanism of type I dehydroquinase from Escherichia coli using two-dimensional 1H,13C NMR.
The Journal of biological chemistry 1998;273(16):9602-7.
1998: Colin Kleanthous; Andrew M Hemmings; Geoffrey R Moore; Richard James
Immunity proteins and their specificity for endonuclease colicins: telling right from wrong in protein-protein recognition.
Molecular microbiology 1998;28(2):227-33.
1998: Theonie Georgiou; Y N Yu; S Ekunwe; Mark J Buttner; AM Zuurmond; Barend Kraal; Colin Kleanthous; L Snyder
Specific peptide-activated proteolytic cleavage of Escherichia coli elongation factor Tu.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(6):2891-5.
1998: R Wallis; K Y Leung; Michael J Osborne; Richard James; Geoffrey R Moore; Colin Kleanthous
Specificity in protein-protein recognition: conserved Im9 residues are the major determinants of stability in the colicin E9 DNase-Im9 complex.
Biochemistry 1998;37(2):476-85.
1997: C Garinot-Schneider; Christopher N Penfold; Geoffrey R Moore; Colin Kleanthous; Richard James
Identification of residues in the putative TolA box which are essential for the toxicity of the endonuclease toxin colicin E9.
Microbiology (Reading, England) 1997;143 ( Pt 9)():2931-8.
1997: Wei Li; Caitriona Dennis; Geoffrey R Moore; Richard James; Colin Kleanthous
Protein-protein interaction specificity of Im9 for the endonuclease toxin colicin E9 defined by homologue-scanning mutagenesis.
The Journal of biological chemistry 1997;272(35):22253-8.
1997: Michael J Osborne; R Wallis; K Y Leung; G Williams; LY Lian; Richard James; Colin Kleanthous; Geoffrey R Moore
Identification of critical residues in the colicin E9 DNase binding region of the Im9 protein.
The Biochemical journal 1997;323 ( Pt 3)():823-31.
1996: J R Bottomley; C L Clayton; P A Chalk; Colin Kleanthous
Cloning, sequencing, expression, purification and preliminary characterization of a type II dehydroquinase from Helicobacter pylori.
The Biochemical journal 1996;319 ( Pt 2)():559-65.
1996: J M Harris; C Gonzalez-Bello; Colin Kleanthous; Alastair R Hawkins; J R Coggins; C Abell
Evidence from kinetic isotope studies for an enolate intermediate in the mechanism of type II dehydroquinases.
The Biochemical journal 1996;319 ( Pt 2)():333-6.
1996: J R Bottomley; Alastair R Hawkins; Colin Kleanthous
Conformational changes and the role of metals in the mechanism of type II dehydroquinase from Aspergillus nidulans.
The Biochemical journal 1996;319 ( Pt 1)():269-78.
1996: C Garinot-Schneider; Ansgar J Pommer; Geoffrey R Moore; Colin Kleanthous; Richard James
Identification of putative active-site residues in the DNase domain of colicin E9 by random mutagenesis.
Journal of molecular biology 1996;260(5):731-42.
1996: Michael J Osborne; A L Breeze; L Y Lian; Ann Reilly; Richard James; Colin Kleanthous; Geoffrey R Moore
Three-dimensional solution structure and 13C nuclear magnetic resonance assignments of the colicin E9 immunity protein Im9.
Biochemistry 1996;35(29):9505-12.
1996: Richard James; Colin Kleanthous; Geoffrey R Moore
The biology of E colicins: paradigms and paradoxes.
Microbiology (Reading, England) 1996;142 ( Pt 7)():1569-80.
1995: A P Leech; Richard James; J R Coggins; Colin Kleanthous
Mutagenesis of active site residues in type I dehydroquinase from Escherichia coli. Stalled catalysis in a histidine to alanine mutant.
The Journal of biological chemistry 1995;270(43):25827-36.
1995: R Wallis; K Y Leung; Ansgar J Pommer; H Videler; Geoffrey R Moore; Richard James; Colin Kleanthous
Protein-protein interactions in colicin E9 DNase-immunity protein complexes. 2. Cognate and noncognate interactions that span the millimolar to femtomolar affinity range.
Biochemistry 1995;34(42):13751-9.
1995: R Wallis; Geoffrey R Moore; Richard James; Colin Kleanthous
Protein-protein interactions in colicin E9 DNase-immunity protein complexes. 1. Diffusion-controlled association and femtomolar binding for the cognate complex.
Biochemistry 1995;34(42):13743-50.
1994: Michael J Osborne; L Y Lian; R Wallis; Ann Reilly; Richard James; Colin Kleanthous; Geoffrey R Moore
Sequential assignments and identification of secondary structure elements of the colicin E9 immunity protein in solution by homonuclear and heteronuclear NMR.
Biochemistry 1994;33(41):12347-55.
1994: R Wallis; Ann Reilly; K Barnes; C Abell; D G Campbell; Geoffrey R Moore; Richard James; Colin Kleanthous
Tandem overproduction and characterisation of the nuclease domain of colicin E9 and its cognate inhibitor protein Im9.
European journal of biochemistry / FEBS 1994;220(2):447-54.
1994: Ann Reilly; P Morgan; K Davis; S M Kelly; J Greene; A J Rowe; S E Harding; N C Price; J R Coggins; Colin Kleanthous
Product-induced stabilization of tertiary and quaternary structure in Escherichia coli dehydroquinase.
The Journal of biological chemistry 1994;269(8):5523-6.
1992: R Wallis; Geoffrey R Moore; Colin Kleanthous; Richard James
Molecular analysis of the protein-protein interaction between the E9 immunity protein and colicin E9.
European journal of biochemistry / FEBS 1992;210(3):923-30.
1992: R K Deka; Colin Kleanthous; John R Coggins
Identification of the essential histidine residue at the active site of Escherichia coli dehydroquinase.
The Journal of biological chemistry 1992;267(31):22237-42.
1992: C W Boys; S M Bury; Lindsay Sawyer; J D Moore; I G Charles; Alastair R Hawkins; R Deka; Colin Kleanthous; J R Coggins
Crystallization of a type I 3-dehydroquinase from Salmonella typhi.
Journal of molecular biology 1992;227(1):352-5.
1992: R Wallis; Ann Reilly; A Rowe; Geoffrey R Moore; Richard James; Colin Kleanthous
In vivo and in vitro characterization of overproduced colicin E9 immunity protein.
European journal of biochemistry / FEBS 1992;207(2):687-95.
1992: Colin Kleanthous; R Deka; K Davis; Sharon M Kelly; Alan Cooper; S E Harding; Nicholas C Price; Alastair R Hawkins; John R Coggins
A comparison of the enzymological and biophysical properties of two distinct classes of dehydroquinase enzymes.
The Biochemical journal 1992;282 ( Pt 3)():687-95.
1992: D P Baker; Colin Kleanthous; J N Keen; E Weinhold; C A Fewson
Mechanistic and active-site studies on D(--)-mandelate dehydrogenase from Rhodotorula graminis.
The Biochemical journal 1992;281 ( Pt 1)():211-8.
1991: Colin Kleanthous; M Reilly; Alan Cooper; S Kelly; Nicholas C Price; John R Coggins
Stabilization of the shikimate pathway enzyme dehydroquinase by covalently bound ligand.
The Journal of biological chemistry 1991;266(17):10893-8.
1990: Colin Kleanthous; John R Coggins
Reversible alkylation of an active site methionine residue in dehydroquinase.
The Journal of biological chemistry 1990;265(19):10935-9.
1990: Colin Kleanthous; D G Campbell; John R Coggins
Active site labeling of the shikimate pathway enzyme, dehydroquinase. Evidence for a common substrate binding site within dehydroquinase and dehydroquinate synthase.
The Journal of biological chemistry 1990;265(19):10929-34.
1989: Hugh G Nimmo; F Douglas; Colin Kleanthous; D G Campbell; C MacKintosh
Identification of a cysteine residue at the active site of Escherichia coli isocitrate lyase.
The Biochemical journal 1989;261(2):431-5.