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Nancy Kleckner

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
7
Zickler, Denise
4
Weiner, BM
4
Storlazzi, Aurora
4
Hunter, Neil
4
Schwacha, Anthony
4
Börner, Valentin
4
Boye, Erik
3
Gargano, Silvana
3
Guhathakurta, A
3
Jain, Chaitanya
3
Blat, Yuval
3
Burgess, Sean
2
Bates, David
2
Skarstad, Kirsten
2
Kwon, DS

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Publications

TOP 3
Danilowicz Claudia; Limouse Charles; Hatch Kristi; Conover Alyson; Coljee Vincent W; Kleckner Nancy; Prentiss Mara
The structure of DNA overstretched from the 5'5' ends differs from the structure of DNA overstretched from the 3'3' ends.
Weiner Beth M; Kleckner Nancy
Assaying chromosome pairing by FISH analysis of spread Saccharomyces cerevisiae nuclei.
Ping Liyan; Weiner Beth; Kleckner Nancy
Tsr-GFP accumulates linearly with time at cell poles, and can be used to differentiate 'old' versus 'new' poles, in Escherichia coli.

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All Publications

2009: Danilowicz Claudia; Limouse Charles; Hatch Kristi; Conover Alyson; Coljee Vincent W; Kleckner Nancy; Prentiss Mara
The structure of DNA overstretched from the 5'5' ends differs from the structure of DNA overstretched from the 3'3' ends.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(32):13196-201.
2009: Weiner Beth M; Kleckner Nancy
Assaying chromosome pairing by FISH analysis of spread Saccharomyces cerevisiae nuclei.
Methods in molecular biology (Clifton, N.J.) 2009;558():37-51.
2008: Ping Liyan; Weiner Beth; Kleckner Nancy
Tsr-GFP accumulates linearly with time at cell poles, and can be used to differentiate 'old' versus 'new' poles, in Escherichia coli.
Molecular microbiology 2008;69(6):1427-38.
2008: Koszul R; Kim K P; Prentiss M; Kleckner N; Kameoka S
Meiotic chromosomes move by linkage to dynamic actin cables with transduction of force through the nuclear envelope.
Cell 2008;133(7):1188-201.
2008: Storlazzi Aurora; Tesse Sophie; Ruprich-Robert Gwenael; Gargano Silvana; Pöggeler Stefanie; Kleckner Nancy; Zickler Denise
Coupling meiotic chromosome axis integrity to recombination.
Genes & development 2008;22(6):796-809.
2008: Börner G Valentin; Barot Aekam; Kleckner Nancy
Yeast Pch2 promotes domainal axis organization, timely recombination progression, and arrest of defective recombinosomes during meiosis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(9):3327-32.
2008: Molnar Monika; Kleckner Nancy
Examination of interchromosomal interactions in vegetatively growing diploid Schizosaccharomyces pombe cells by Cre/loxP site-specific recombination.
Genetics 2008;178(1):99-112.
2008: Wanat Jennifer J; Kim Keun P; Koszul Romain; Zanders Sarah; Weiner Beth; Kleckner Nancy; Alani Eric
Csm4, in collaboration with Ndj1, mediates telomere-led chromosome dynamics and recombination during yeast meiosis.
PLoS genetics 2008;4(9):e1000188.
2007: Terasawa Masahiro; Ogawa Hideyuki; Tsukamoto Yasumasa; Shinohara Miki; Shirahige Katsuhiko; Kleckner Nancy; Ogawa Tomoko
Meiotic recombination-related DNA synthesis and its implications for cross-over and non-cross-over recombinant formation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(14):5965-70.
2006: Kleckner Nancy
Chiasma formation: chromatin/axis interplay and the role(s) of the synaptonemal complex.
Chromosoma 2006;115(3):175-94.
2005: Perry Jason; Kleckner Nancy; Börner G Valentin
Bioinformatic analyses implicate the collaborating meiotic crossover/chiasma proteins Zip2, Zip3, and Spo22/Zip4 in ubiquitin labeling.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(49):17594-9.
2005: Bates David; Epstein Jessica; Boye Erik; Fahrner Karen; Berg Howard; Kleckner Nancy
The Escherichia coli baby cell column: a novel cell synchronization method provides new insight into the bacterial cell cycle.
Molecular microbiology 2005;57(2):380-91.
2005: Bates David; Kleckner Nancy
Chromosome and replisome dynamics in E. coli: loss of sister cohesion triggers global chromosome movement and mediates chromosome segregation.
Cell 2005;121(6):899-911.
2004: Kleckner Nancy; Zickler Denise; Jones Gareth H; Dekker Job; Padmore Ruth; Henle Jim; Hutchinson John
A mechanical basis for chromosome function.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(34):12592-7.
2004: Börner G Valentin; Kleckner Nancy; Hunter Neil
Crossover/noncrossover differentiation, synaptonemal complex formation, and regulatory surveillance at the leptotene/zygotene transition of meiosis.
Cell 2004;117(1):29-45.
2003: Kleckner Nancy; Storlazzi Aurora; Zickler Denise
Coordinate variation in meiotic pachytene SC length and total crossover/chiasma frequency under conditions of constant DNA length.
Trends in genetics : TIG 2003;19(11):623-8.
2003: Storlazzi Aurora; Tessé Sophie; Gargano Silvana; James Françoise; Kleckner Nancy; Zickler Denise
Meiotic double-strand breaks at the interface of chromosome movement, chromosome remodeling, and reductional division.
Genes & development 2003;17(21):2675-87.
2003: Tessé Sophie; Storlazzi Aurora; Kleckner Nancy; Gargano Silvana; Zickler Denise
Localization and roles of Ski8p protein in Sordaria meiosis and delineation of three mechanistically distinct steps of meiotic homolog juxtaposition.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):12865-70.
2003: Nilssen Esben A; Synnes Marianne; Kleckner Nancy; Grallert Beáta; Boye Erik
Intra-G1 arrest in response to UV irradiation in fission yeast.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10758-63.
2003: Perry Jason; Kleckner Nancy
The ATRs, ATMs, and TORs are giant HEAT repeat proteins.
Cell 2003;112(2):151-5.
2002: Blat Yuval; Protacio Reine U; Hunter Neil; Kleckner Nancy
Physical and functional interactions among basic chromosome organizational features govern early steps of meiotic chiasma formation.
Cell 2002;111(6):791-802.
2002: Cha Rita S; Kleckner Nancy
ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones.
Science (New York, N.Y.) 2002;297(5581):602-6.
2002: Bachant Jeff; Alcasabas Annette; Blat Yuval; Kleckner Nancy; Elledge Stephen J
The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II.
Molecular cell 2002;9(6):1169-82.
2002: Dekker Job; Rippe Karsten; Dekker Martijn; Kleckner Nancy
Capturing chromosome conformation.
Science (New York, N.Y.) 2002;295(5558):1306-11.
2001: Hunter N; Kleckner N
The single-end invasion: an asymmetric intermediate at the double-strand break to double-holliday junction transition of meiotic recombination.
Cell 2001;106(1):59-70.
2001: Hunter N; Börner G V; Lichten M; Kleckner N
Gamma-H2AX illuminates meiosis.
Nature genetics 2001;27(3):236-8.
2000: Cha R S; Weiner B M; Keeney S; Dekker J; Kleckner N
Progression of meiotic DNA replication is modulated by interchromosomal interaction proteins, negatively by Spo11p and positively by Rec8p.
Genes & development 2000;14(4):493-503.
2000: Sakai J S; Kleckner N; Yang X; Guhathakurta A
Tn10 transpososome assembly involves a folded intermediate that must be unfolded for target capture and strand transfer.
The EMBO journal 2000;19(4):776-85.
1999: Blat Y; Kleckner N
Cohesins bind to preferential sites along yeast chromosome III, with differential regulation along arms versus the centric region.
Cell 1999;98(2):249-59.
1999: Burgess S M; Kleckner N
Collisions between yeast chromosomal loci in vivo are governed by three layers of organization.
Genes & development 1999;13(14):1871-83.
1999: Burgess S M; Kleckner N; Weiner B M
Somatic pairing of homologs in budding yeast: existence and modulation.
Genes & development 1999;13(12):1627-41.
1999: Burgess S M; Ajimura M; Kleckner N
GCN5-dependent histone H3 acetylation and RPD3-dependent histone H4 deacetylation have distinct, opposing effects on IME2 transcription, during meiosis and during vegetative growth, in budding yeast.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6835-40.
1999: Zickler D; Kleckner N
Meiotic chromosomes: integrating structure and function.
Annual review of genetics 1999;33():603-754.
1998: Kennedy A K; Guhathakurta A; Kleckner N; Haniford D B
Tn10 transposition via a DNA hairpin intermediate.
Cell 1998;95(1):125-34.
1998: Wold S; Boye E; Slater S; Kleckner N; Skarstad K
Effects of purified SeqA protein on oriC-dependent DNA replication in vitro.
The EMBO journal 1998;17(14):4158-65.
1998: Chalmers R; Guhathakurta A; Benjamin H; Kleckner N
IHF modulation of Tn10 transposition: sensory transduction of supercoiling status via a proposed protein/DNA molecular spring.
Cell 1998;93(5):897-908.
1998: Zickler D; Kleckner N
The leptotene-zygotene transition of meiosis.
Annual review of genetics 1998;32():619-97.
1997: Schwacha A; Kleckner N
Interhomolog bias during meiotic recombination: meiotic functions promote a highly differentiated interhomolog-only pathway.
Cell 1997;90(6):1123-35.
1997: McKee A H; Kleckner N
Mutations in Saccharomyces cerevisiae that block meiotic prophase chromosome metabolism and confer cell cycle arrest at pachytene identify two new meiosis-specific genes SAE1 and SAE3.
Genetics 1997;146(3):817-34.
1997: McKee A H; Kleckner N
A general method for identifying recessive diploid-specific mutations in Saccharomyces cerevisiae, its application to the isolation of mutants blocked at intermediate stages of meiotic prophase and characterization of a new gene SAE2.
Genetics 1997;146(3):797-816.
1997: Sakai J; Kleckner N
The Tn10 synaptic complex can capture a target DNA only after transposon excision.
Cell 1997;89(2):205-14.
1997: Keeney S; Giroux C N; Kleckner N
Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family.
Cell 1997;88(3):375-84.
1997: Xu L; Weiner B M; Kleckner N
Meiotic cells monitor the status of the interhomolog recombination complex.
Genes & development 1997;11(1):106-18.
1996: Sakai J; Kleckner N
Two classes of Tn10 transposase mutants that suppress mutations in the Tn10 terminal inverted repeat.
Genetics 1996;144(3):861-70.
1996: Chalmers R M; Kleckner N
IS10/Tn10 transposition efficiently accommodates diverse transposon end configurations.
The EMBO journal 1996;15(18):5112-22.
1996: Storlazzi A; Xu L; Schwacha A; Kleckner N
Synaptonemal complex (SC) component Zip1 plays a role in meiotic recombination independent of SC polymerization along the chromosomes.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):9043-8.
1996: Kleckner N
Meiosis: how could it work?
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8167-74.
1996: Keeney S; Kleckner N
Communication between homologous chromosomes: genetic alterations at a nuclease-hypersensitive site can alter mitotic chromatin structure at that site both in cis and in trans.
Genes to cells : devoted to molecular & cellular mechanisms 1996;1(5):475-89.
1996: Bolland S; Kleckner N
The three chemical steps of Tn10/IS10 transposition involve repeated utilization of a single active site.
Cell 1996;84(2):223-33.
1996: Kleckner N; Chalmers R M; Kwon D; Sakai J; Bolland S
Tn10 and IS10 transposition and chromosome rearrangements: mechanism and regulation in vivo and in vitro.
Current topics in microbiology and immunology 1996;204():49-82.
1995: Xu L; Ajimura M; Padmore R; Klein C; Kleckner N
NDT80, a meiosis-specific gene required for exit from pachytene in Saccharomyces cerevisiae.
Molecular and cellular biology 1995;15(12):6572-81.
1995: Schwacha A; Kleckner N
Identification of double Holliday junctions as intermediates in meiotic recombination.
Cell 1995;83(5):783-91.
1995: Keeney S; Kleckner N
Covalent protein-DNA complexes at the 5' strand termini of meiosis-specific double-strand breaks in yeast.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(24):11274-8.
1995: Xu L; Kleckner N
Sequence non-specific double-strand breaks and interhomolog interactions prior to double-strand break formation at a meiotic recombination hot spot in yeast.
The EMBO journal 1995;14(20):5115-28.
1995: Sakai J; Chalmers R M; Kleckner N
Identification and characterization of a pre-cleavage synaptic complex that is an early intermediate in Tn10 transposition.
The EMBO journal 1995;14(17):4374-83.
1995: Slater S; Wold S; Lu M; Boye E; Skarstad K; Kleckner N
E. coli SeqA protein binds oriC in two different methyl-modulated reactions appropriate to its roles in DNA replication initiation and origin sequestration.
Cell 1995;82(6):927-36.
1995: Storlazzi A; Xu L; Cao L; Kleckner N
Crossover and noncrossover recombination during meiosis: timing and pathway relationships.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8512-6.
1995: Kwon D; Chalmers R M; Kleckner N
Structural domains of IS10 transposase and reconstitution of transposition activity from proteolytic fragments lacking an interdomain linker.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8234-8.
1995: Bolland S; Kleckner N
The two single-strand cleavages at each end of Tn10 occur in a specific order during transposition.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(17):7814-8.
1995: Signon L; Kleckner N
Negative and positive regulation of Tn10/IS10-promoted recombination by IHF: two distinguishable processes inhibit transposition off of multicopy plasmid replicons and activate chromosomal events that favor evolution of new transposons.
Genes & development 1995;9(9):1123-36.
1995: Kleckner N
Interactions between and along chromosomes during meiosis.
Harvey lectures 1995;91():21-45.
1994: Weiner B M; Kleckner N
Chromosome pairing via multiple interstitial interactions before and during meiosis in yeast.
Cell 1994;77(7):977-91.
1994: Lu M; Campbell J L; Boye E; Kleckner N
SeqA: a negative modulator of replication initiation in E. coli.
Cell 1994;77(3):413-26.
1994: Chalmers R M; Kleckner N
Tn10/IS10 transposase purification, activation, and in vitro reaction.
The Journal of biological chemistry 1994;269(11):8029-35.
1994: Schwacha A; Kleckner N
Identification of joint molecules that form frequently between homologs but rarely between sister chromatids during yeast meiosis.
Cell 1994;76(1):51-63.
1993: Raymond W E; Kleckner N
RAD50 protein of S.cerevisiae exhibits ATP-dependent DNA binding.
Nucleic acids research 1993;21(16):3851-6.
1993: Jain C; Kleckner N
Preferential cis action of IS10 transposase depends upon its mode of synthesis.
Molecular microbiology 1993;9(2):249-60.
1993: Jain C; Kleckner N
IS10 mRNA stability and steady state levels in Escherichia coli: indirect effects of translation and role of rne function.
Molecular microbiology 1993;9(2):233-47.
1993: Kleckner N; Weiner B M
Potential advantages of unstable interactions for pairing of chromosomes in meiotic, somatic, and premeiotic cells.
Cold Spring Harbor symposia on quantitative biology 1993;58():553-65.
1992: Bender J; Kleckner N
Tn10 insertion specificity is strongly dependent upon sequences immediately adjacent to the target-site consensus sequence.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(17):7996-8000.
1992: Mahillon J; Kleckner N
New IS10 transposition vectors based on a gram-positive replication origin.
Gene 1992;116(1):69-74.
1992: Bishop D K; Park D; Xu L; Kleckner N
DMC1: a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression.
Cell 1992;69(3):439-56.
1992: Benjamin H W; Kleckner N
Excision of Tn10 from the donor site during transposition occurs by flush double-strand cleavages at the transposon termini.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(10):4648-52.
1992: Bender J; Kleckner N
IS10 transposase mutations that specifically alter target site recognition.
The EMBO journal 1992;11(2):741-50.
1991: Padmore R; Cao L; Kleckner N
Temporal comparison of recombination and synaptonemal complex formation during meiosis in S. cerevisiae.
Cell 1991;66(6):1239-56.
1991: Bender J; Kuo J; Kleckner N
Genetic evidence against intramolecular rejoining of the donor DNA molecule following IS10 transposition.
Genetics 1991;128(4):687-94.
1991: Roberts D E; Ascherman D; Kleckner N
IS10 promotes adjacent deletions at low frequency.
Genetics 1991;128(1):37-43.
1991: Haniford D B; Benjamin H W; Kleckner N
Kinetic and structural analysis of a cleaved donor intermediate and a strand transfer intermediate in Tn10 transposition.
Cell 1991;64(1):171-9.
1991: Kleckner N; Padmore R; Bishop D K
Meiotic chromosome metabolism: one view.
Cold Spring Harbor symposia on quantitative biology 1991;56():729-43.
1990: Campbell J L; Kleckner N
E. coli oriC and the dnaA gene promoter are sequestered from dam methyltransferase following the passage of the chromosomal replication fork.
Cell 1990;62(5):967-79.
1990: Cao L; Alani E; Kleckner N
A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae.
Cell 1990;61(6):1089-101.
1990: Alani E; Padmore R; Kleckner N
Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination.
Cell 1990;61(3):419-36.
1989: Kittle J D; Simons R W; Lee J; Kleckner N
Insertion sequence IS10 anti-sense pairing initiates by an interaction between the 5' end of the target RNA and a loop in the anti-sense RNA.
Journal of molecular biology 1989;210(3):561-72.
1989: Haniford D B; Chelouche A R; Kleckner N
A specific class of IS10 transposase mutants are blocked for target site interactions and promote formation of an excised transposon fragment.
Cell 1989;59(2):385-94.
1989: Benjamin H W; Kleckner N
Intramolecular transposition by Tn10.
Cell 1989;59(2):373-83.
1989: Huisman O; Errada P R; Signon L; Kleckner N
Mutational analysis of IS10's outside end.
The EMBO journal 1989;8(7):2101-9.
1988: Campbell J L; Kleckner N
The rate of Dam-mediated DNA adenine methylation in Escherichia coli.
Gene 1988;74(1):189-90.
1988: Roberts D; Kleckner N
Tn10 transposition promotes RecA-dependent induction of a lambda prophage.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(16):6037-41.
1988: Sen J; Septak M; Jain C; Kleckner N
Translation start of IS10 transposase protein.
Nucleic acids research 1988;16(10):4730.
1987: Morisato D; Kleckner N
Tn10 transposition and circle formation in vitro.
Cell 1987;51(1):101-11.
1987: Alani E; Kleckner N
A new type of fusion analysis applicable to many organisms: protein fusions to the URA3 gene of yeast.
Genetics 1987;117(1):5-12.
1984: Way J C; Davis M A; Morisato D; Roberts D E; Kleckner N
New Tn10 derivatives for transposon mutagenesis and for construction of lacZ operon fusions by transposition.
Gene 1984;32(3):369-79.
1984: Morisato D; Kleckner N
Transposase promotes double strand breaks and single strand joints at Tn10 termini in vivo.
Cell 1984;39(1):181-90.
1984: Kleckner N; Morisato D; Roberts D; Bender J
Mechanism and regulation of Tn10 transposition.
Cold Spring Harbor symposia on quantitative biology 1984;49():235-44.
1983: Morisato D; Way J C; Kim H J; Kleckner N
Tn10 transposase acts preferentially on nearby transposon ends in vivo.
Cell 1983;32(3):799-807.

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