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Ralf Kleene

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Thomas Theis; Maren von der Ohe; Perry J Blackshear; Gabriele Loers; Bibhudatta Mishra; Ole Pless; Maksymilian Prondzynski; Melitta Schachner; Ralf Kleene
Functional role of the interaction between polysialic acid and myristoylated alanine-rich C kinase substrate at the plasma membrane.
Nina Stemmer; Elena Strekalova; Friedrich Buck; Nevena Djogo; Gabriele Loers; David Lutz; Marek Michalak; Frank Plöger; Melitta Schachner; Ralf Kleene
Generation of Amyloid-β Is Reduced by the Interaction of Calreticulin with Amyloid Precursor Protein, Presenilin and Nicastrin.
David Lutz; Melitta Schachner; Gerrit Wolters-Eisfeld; Nevena Djogo; Igor Jakovcevski; Gunjan Joshi; Ralf Kleene
Generation and nuclear translocation of sumoylated transmembrane fragment of cell adhesion molecule L1.

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2013: Thomas Theis; Maren von der Ohe; Perry J Blackshear; Gabriele Loers; Bibhudatta Mishra; Ole Pless; Maksymilian Prondzynski; Melitta Schachner; Ralf Kleene
Functional role of the interaction between polysialic acid and myristoylated alanine-rich C kinase substrate at the plasma membrane.
The Journal of biological chemistry 2013;288(9):6726-42.
2013: Nina Stemmer; Elena Strekalova; Friedrich Buck; Nevena Djogo; Gabriele Loers; David Lutz; Marek Michalak; Frank Plöger; Melitta Schachner; Ralf Kleene
Generation of Amyloid-β Is Reduced by the Interaction of Calreticulin with Amyloid Precursor Protein, Presenilin and Nicastrin.
PloS one 2013;8(4):e61299.
2012: David Lutz; Melitta Schachner; Gerrit Wolters-Eisfeld; Nevena Djogo; Igor Jakovcevski; Gunjan Joshi; Ralf Kleene
Generation and nuclear translocation of sumoylated transmembrane fragment of cell adhesion molecule L1.
The Journal of biological chemistry 2012;287(21):17161-75.
2012: Gabriele Loers; Tatjana Makhina; Melitta Schachner; Ute Bork; Andrea Dörner; Ralf Kleene
The interaction between cell adhesion molecule L1, matrix metalloproteinase 14, and adenine nucleotide translocator at the plasma membrane regulates L1-mediated neurite outgrowth of murine cerebellar neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(11):3917-30.
2012: Yan Wang; Wei-Jiang Zhao; Guillaume Hebert; Julia Costa; Ricardo Gouveia; Ralf Kleene; Gabriele Loers; Hong-Chao Pan; Melitta Schachner
Antibody fragments directed against different portions of the human neural cell adhesion molecule L1 act as inhibitors or activators of L1 function.
PloS one 2012;7(12):e52404.
2011: Shiwei Wang; Gabriele Loers; Melitta Schachner; Michaela Schweizer; Fabio Benfenati; Friedrich Buck; Fabrizia Cesca; Ralf Kleene
Synapsin I is an oligomannose-carrying glycoprotein, acts as an oligomannose-binding lectin, and promotes neurite outgrowth and neuronal survival when released via glia-derived exosomes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(20):7275-90.
2010: Bibhudatta Mishra; Maren von der Ohe; Christian Schulze; Shan Bian; Tatjana Makhina; Gabriele Loers; Ralf Kleene; Melitta Schachner
Functional role of the interaction between polysialic acid and extracellular histone H1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(37):12400-13.
2010: Ralf Kleene; Claas Cassens; Robert Bähring; Thomas Theis; Mei-Fang Xiao; Alexander Dityatev; Claus Schafer-Nielsen; Frank Döring; Erhard Wischmeyer; Melitta Schachner
Functional consequences of the interactions among the neural cell adhesion molecule NCAM, the receptor tyrosine kinase TrkB, and the inwardly rectifying K+ channel KIR3.3.
The Journal of biological chemistry 2010;285(37):28968-79.
2010: Claas Cassens; Ralf Kleene; Mei-Fang Xiao; Claudia Friedrich; Galina Dityateva; Claus Schafer-Nielsen; Melitta Schachner
Binding of the receptor tyrosine kinase TrkB to the neural cell adhesion molecule (NCAM) regulates phosphorylation of NCAM and NCAM-dependent neurite outgrowth.
The Journal of biological chemistry 2010;285(37):28959-67.
2010: Ralf Kleene; Mounir Mzoughi; Gunjan Joshi; Ina Kalus; Ulrich Bormann; Christian Schulze; Mei-Fang Xiao; Alexander Dityatev; Melitta Schachner
NCAM-induced neurite outgrowth depends on binding of calmodulin to NCAM and on nuclear import of NCAM and fak fragments.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(32):10784-98.
2010: Nainesh Katagihallimath; Ali Mehanna; Daria Guseva; Ralf Kleene; Melitta Schachner
Identification and validation of a Lewis x glycomimetic peptide.
European journal of cell biology 2010;89(1):77-86.
2009: Mei-Fang Xiao; Jin-Chong Xu; Yuliya Tereshchenko; Daniel Novak; Melitta Schachner; Ralf Kleene
Neural cell adhesion molecule modulates dopaminergic signaling and behavior by regulating dopamine D2 receptor internalization.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(47):14752-63.
2009: Christina Bleckmann; Hildegard Geyer; Annika Lieberoth; Frauke Splittstoesser; Yan Liu; Ten Feizi; Melitta Schachner; Ralf Kleene; Vernon Reinhold; Rudolf Geyer
O-glycosylation pattern of CD24 from mouse brain.
Biological chemistry 2009;390(7):627-45.
2009: Tatjana Makhina; Gabriele Loers; Christian Schulze; Barbara Ueberle; Melitta Schachner; Ralf Kleene
Extracellular GAPDH binds to L1 and enhances neurite outgrowth.
Molecular and cellular neurosciences 2009;41(2):206-18.
2009: Annika Lieberoth; Frauke Splittstoesser; Nainesh Katagihallimath; Igor Jakovcevski; Gabriele Loers; Barbara Ranscht; Domna Karagogeos; Melitta Schachner; Ralf Kleene
Lewis(x) and alpha2,3-sialyl glycans and their receptors TAG-1, Contactin, and L1 mediate CD24-dependent neurite outgrowth.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(20):6677-90.
2007: Ralf Kleene; Gabriele Loers; Julia Langer; Yveline Frobert; Friedrich Buck; Melitta Schachner
Prion protein regulates glutamate-dependent lactate transport of astrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(45):12331-40.
2007: Alexander Dityatev; Gert Brückner; Galina Dityateva; Jens Grosche; Ralf Kleene; Melitta Schachner
Activity-dependent formation and functions of chondroitin sulfate-rich extracellular matrix of perineuronal nets.
Developmental neurobiology 2007;67(5):570-88.
2006: Ina Kalus; Ulrich Bormann; Mounir Mzoughi; Melitta Schachner; Ralf Kleene
Proteolytic cleavage of the neural cell adhesion molecule by ADAM17/TACE is involved in neurite outgrowth.
Journal of neurochemistry 2006;98(1):78-88.
2006: Helen Strekalova; Carsten Buhmann; Ralf Kleene; Christian Eggers; Jane Saffell; John Hemperly; Cornelius Weiller; Tomas Müller-Thomsen; Melitta Schachner
Elevated levels of neural recognition molecule L1 in the cerebrospinal fluid of patients with Alzheimer disease and other dementia syndromes.
Neurobiology of aging 2006;27(1):1-9.
2005: Thirumalini Vaithianathan; Kandiah Manivannan; Ralf Kleene; Ben A Bahr; Markus P Dey; Alexander Dityatev; Vishnu Suppiramaniam
Single channel recordings from synaptosomal AMPA receptors.
Cell biochemistry and biophysics 2005;42(1):75-85.
2004: Ralf Kleene; Melitta Schachner
Glycans and neural cell interactions.
Nature reviews. Neuroscience 2004;5(3):195-208.
2003: Ina Kalus; Birthe Schnegelsberg; Nabil G Seidah; Ralf Kleene; Melitta Schachner
The proprotein convertase PC5A and a metalloprotease are involved in the proteolytic processing of the neural adhesion molecule L1.
The Journal of biological chemistry 2003;278(12):10381-8.
2003: Annette Biederbick; Alexander Licht; Ralf Kleene
Serglycin proteoglycan is sorted into zymogen granules of rat pancreatic acinar cells.
European journal of cell biology 2003;82(1):19-29.
2002: Ina Kalus; Alois Hodel; Annett Koch; Ralf Kleene; J Michael Edwardson; Michael Schrader
Interaction of syncollin with GP-2, the major membrane protein of pancreatic zymogen granules, and association with lipid microdomains.
The Biochemical journal 2002;362(Pt 2):433-42.
2001: Ralf Kleene; Huibin Yang; Michael Kutsche; Melitta Schachner
The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth.
The Journal of biological chemistry 2001;276(24):21656-63.
2001: K Schmidt; Michael Schrader; HF Kern; Ralf Kleene
Regulated apical secretion of zymogens in rat pancreas. Involvement of the glycosylphosphatidylinositol-anchored glycoprotein GP-2, the lectin ZG16p, and cholesterol-glycosphingolipid-enriched microdomains.
The Journal of biological chemistry 2001;276(17):14315-23.
2000: Ralf Kleene; B Classen; J Zdzieblo; Michael Schrader
SH3 binding sites of ZG29p mediate an interaction with amylase and are involved in condensation-sorting in the exocrine rat pancreas.
Biochemistry 2000;39(32):9893-900.
2000: K Schmidt; H Dartsch; D Linder; HF Kern; Ralf Kleene
A submembranous matrix of proteoglycans on zymogen granule membranes is involved in granule formation in rat pancreatic acinar cells.
Journal of cell science 2000;113 ( Pt 12)():2233-42.
1999: Ralf Kleene; J Zdzieblo; K Wege; HF Kern
A novel zymogen granule protein (ZG29p) and the nuclear protein MTA1p are differentially expressed by alternative transcription initiation in pancreatic acinar cells of the rat.
Journal of cell science 1999;112 ( Pt 15)():2539-48.
1999: Ralf Kleene; Berthold Kastner; Ralf Rösser; HF Kern
Complex formation among rat pancreatic secretory proteins under mild alkaline pH conditions.
Digestion 1999;60(4):305-13.
1999: Ralf Kleene; H Dartsch; HF Kern
The secretory lectin ZG16p mediates sorting of enzyme proteins to the zymogen granule membrane in pancreatic acinar cells.
European journal of cell biology 1999;78(2):79-90.
1998: T Höfken; D Linder; Ralf Kleene; Burkhard Göke; Andreas C C Wagner
Membrane dipeptidase and glutathione are major components of pig pancreatic zymogen granules.
Experimental cell research 1998;244(2):481-90.
1998: H Dartsch; Ralf Kleene; HF Kern
In vitro condensation-sorting of enzyme proteins isolated from rat pancreatic acinar cells.
European journal of cell biology 1998;75(3):211-22.