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Ludger Klein-Hitpass

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Oligonucleotide Array Sequence Analysis

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Physiology

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B-Cell Chronic Lymphocytic Leukemia

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Tea Berulava; Ludger Klein-Hitpass; Emil Mladenov; Ulrich Rüther; Jürgen Thomale; Matthias Ziehe; Bernhard Horsthemke
FTO levels affect RNA modification and the transcriptome.
Gloria Lutzny; Robert Oostendorp; Christian Peschel; Jan Dürig; Alexander Egle; Andrew J Finch; Claudia Haferlach; Ludger Klein-Hitpass; Thomas Kocher; Alexander Kohlmann; Toni Kuhnt; Benedikt Lampl; Michael Leitges; Martina Rudelius; Jürgen Ruland; Yvonne Schäfer; Marc Schmidt-Supprian; Susanne Schnittger; Marc Seifert; Michaela Wagner; Stefan Wanninger; Nadja Zaborsky; Ingo Ringshausen
Protein kinase c-β-dependent activation of NF-κB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo.
Jan J Molenaar; Alexander Schramm; Isabella Bray; Marloes Broekmans; Huib N Caron; Raquel Domingo-Fernández; Ksenija Drabek; Marli E Ebus; Angelika Eggert; Matthias Fischer; Franciska Haneveld; Lukas Heukamp; Kristina Kieckbusch; Ludger Klein-Hitpass; Jan Koster; Sven Lindner; Pieter Mestdagh; Frank Speleman; Annika Sprüssel; Raymond L Stallings; Theresa Thor; Linda J Valentijn; Johan van Nes; Max M van Noesel; Peter G van Sluis; Jo Vandesompele; Luigi Varesio; Rogier Versteeg; Richard Volckmann; Johannes H Schulte
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.

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All Publications

2013: Tea Berulava; Ludger Klein-Hitpass; Emil Mladenov; Ulrich Rüther; Jürgen Thomale; Matthias Ziehe; Bernhard Horsthemke
FTO levels affect RNA modification and the transcriptome.
European journal of human genetics : EJHG 2013;21(3):317-23.
2013: Gloria Lutzny; Robert Oostendorp; Christian Peschel; Jan Dürig; Alexander Egle; Andrew J Finch; Claudia Haferlach; Ludger Klein-Hitpass; Thomas Kocher; Alexander Kohlmann; Toni Kuhnt; Benedikt Lampl; Michael Leitges; Martina Rudelius; Jürgen Ruland; Yvonne Schäfer; Marc Schmidt-Supprian; Susanne Schnittger; Marc Seifert; Michaela Wagner; Stefan Wanninger; Nadja Zaborsky; Ingo Ringshausen
Protein kinase c-β-dependent activation of NF-κB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo.
Cancer cell 2013;23(1):77-92.
2012: Jan J Molenaar; Alexander Schramm; Isabella Bray; Marloes Broekmans; Huib N Caron; Raquel Domingo-Fernández; Ksenija Drabek; Marli E Ebus; Angelika Eggert; Matthias Fischer; Franciska Haneveld; Lukas Heukamp; Kristina Kieckbusch; Ludger Klein-Hitpass; Jan Koster; Sven Lindner; Pieter Mestdagh; Frank Speleman; Annika Sprüssel; Raymond L Stallings; Theresa Thor; Linda J Valentijn; Johan van Nes; Max M van Noesel; Peter G van Sluis; Jo Vandesompele; Luigi Varesio; Rogier Versteeg; Richard Volckmann; Johannes H Schulte
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.
Nature genetics 2012;44(11):1199-206.
2012: Regina Ebert; Lorenz C Hofbauer; Peggy Benad; Ludger Klein-Hitpass; Barbara Klotz; Jutta Meissner-Weigl; Tilman D Rachner; Maximilian Rudert; Sabine Zeck; Franz Jakob
Krüppel-like factors KLF2 and 6 and Ki-67 are direct targets of zoledronic acid in MCF-7 cells.
Bone 2012;50(3):723-32.
2012: Peggy Benisch; Regina Ebert; Sönke P Frey; Michael Amling; Ludger Klein-Hitpass; Melanie Krug; Nadja Raaijmakers; Martina Regensburger; Tatjana Schilling; Thorsten Schinke; Lothar Seefried; Sabine Zeck; Franz Jakob
The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors.
PloS one 2012;7(9):e45142.
2012: Maher Hanoun; Andreas Hüttmann; Ludger Klein-Hitpass; René Scholtysik; Masako Suzuki; Semra Aydin; Ulrich Dührsen; Lewin Eisele; John M Greally; Jan Dürig
Epigenetic silencing of the circadian clock gene CRY1 is associated with an indolent clinical course in chronic lymphocytic leukemia.
PloS one 2012;7(3):e34347.
2011: Christian Schwerk; Barbara Spellerberg; Carolin Stump; Tobias Tenenbaum; Sascha Zink; Rüdiger Adam; Julia Borkowski; Ludger Klein-Hitpass; Michael Klenk; Dirk Koczan; Natascha Quednau; Anubha Sagar; Nicole Schmidt; Henriette Schneider; Horst Schroten
In vitro transcriptome analysis of porcine choroid plexus epithelial cells in response to Streptococcus suis: release of pro-inflammatory cytokines and chemokines.
Microbes and infection / Institut Pasteur 2011;13(11):953-62.
2011: Ingrid Saba; Lothar Vassen; Ludger Klein-Hitpass; Christian Kosan; Tarik Möröy
Miz-1 is required to coordinate the expression of TCRbeta and p53 effector genes at the pre-TCR "beta-selection" checkpoint.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(6):2982-92.
2011: Diana Mitter; Artur Muradyan; Katrin Ounap; Reinhard Ullmann; Deniz Kanber; Marc Kaulisch; Ludger Klein-Hitpass; Dietmar Lohmann
Genotype-phenotype correlations in patients with retinoblastoma and interstitial 13q deletions.
European journal of human genetics : EJHG 2011;19(9):947-58.
2011: Sebastian Gustmann; Ludger Klein-Hitpass; Harald Stephan; Susanne Weber; Norbert Bornfeld; Marc Kaulisch; Dietmar R Lohmann; Nicole Dünker
Loss at chromosome arm 16q in retinoblastoma: confirmation of the association with diffuse vitreous seeding and refinement of the recurrently deleted region.
Genes, chromosomes & cancer 2011;50(5):327-37.
2011: Jan Dürig; Ulrich Dührsen; Ludger Klein-Hitpass; J Worm; J B Rode Hansen; H Ørum; M Wissenbach
The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia.
Leukemia 2011;25(4):638-47.
2011: Andrea Wirsing; Sabine Senkel; Ludger Klein-Hitpass; Gerhart U Ryffel
A systematic analysis of the 3'UTR of HNF4A mRNA reveals an interplay of regulatory elements including miRNA target sites.
PloS one 2011;6(11):e27438.
2010: Ludger Sellmann; Rene Scholtysik; Markus Kreuz; Sandra Cyrull; Enrico Tiacci; Jens Stanelle; Alexander Carpinteiro; Holger Nückel; Tanja Boes; Stefan Gesk; Reiner Siebert; Ludger Klein-Hitpass; Ulrich Dührsen; Jan Dürig; Ralf Küppers
Gene dosage effects in chronic lymphocytic leukemia.
Cancer genetics and cytogenetics 2010;203(2):149-60.
2010: Adrien Daigeler; Ansgar M Chromik; Kathrin Haendschke; Sabine Emmelmann; Monica Siepmann; Karin Hensel; Georg Schmitz; Ludger Klein-Hitpass; Hans U Steinau; Marcus Lehnhardt; Joerg Hauser
Synergistic effects of sonoporation and taurolidin/TRAIL on apoptosis in human fibrosarcoma.
Ultrasound in medicine & biology 2010;36(11):1893-906.
2010: P Johansson; L Eisele; Ludger Klein-Hitpass; Ludger Sellmann; Ulrich Dührsen; Jan Dürig; Holger Nückel
Percentage of smudge cells determined on routine blood smears is a novel prognostic factor in chronic lymphocytic leukemia.
Leukemia research 2010;34(7):892-8.
2010: Catarina Limbert; Regina Ebert; Tatjana Schilling; Gunter Path; Peggy Benisch; Ludger Klein-Hitpass; Jochen Seufert; Franz Jakob
Functional signature of human islet-derived precursor cells compared to bone marrow-derived mesenchymal stem cells.
Stem cells and development 2010;19(5):679-91.
2010: Corinna Schirling; Christiane Heseding; Franziska Heise; Dörthe Kesper; Ansgar Klebes; Ludger Klein-Hitpass; Andrea Vortkamp; Daniel Hoffmann; Harald Saumweber; Ann E Ehrenhofer-Murray
Widespread regulation of gene expression in the Drosophila genome by the histone acetyltransferase dTip60.
Chromosoma 2010;119(1):99-113.
2010: C Lanckohr; Alice Kasprzynski; Ludger Klein-Hitpass; H-H Homann; Marcus Lehnhardt; Oliver Müller; Cornelius Kuhnen; Peter Herter
[Identification of genes over-expressed in myxoid/round cell liposarcoma. DNA microarray analysis and immunohistochemical correlation].
Der Pathologe 2010;31(1):60-6.
2010: Anna Kosubek; Ludger Klein-Hitpass; Katrin Rademacher; Bernhard Horsthemke; Gerhart U Ryffel
Aging of Xenopus tropicalis eggs leads to deadenylation of a specific set of maternal mRNAs and loss of developmental potential.
PloS one 2010;5(10):e13532.
2009: Katja Specht; Nadia Harbeck; Jan Smida; Katja Annecke; Ulrike Reich; Joerg Naehrig; Rupert Langer; Joerg Mages; Raymonde Busch; Elisabeth Kruse; Ludger Klein-Hitpass; Manfred Schmitt; Marion Kiechle; Heinz Hoefler
Expression profiling identifies genes that predict recurrence of breast cancer after adjuvant CMF-based chemotherapy.
Breast cancer research and treatment 2009;118(1):45-56.
2009: Lewin Eisele; Robert Prinz; Ludger Klein-Hitpass; Holger Nückel; Kerstin Lowinski; Jürgen Thomale; Lars C Moeller; Ulrich Dührsen; Jan Dürig
Combined PER2 and CRY1 expression predicts outcome in chronic lymphocytic leukemia.
European journal of haematology 2009;83(4):320-7.
2009: Stefanie Bug; Jan Dürig; Florian Oyen; Ludger Klein-Hitpass; Jose I Martin-Subero; Lana Harder; Baudis Michael; Norbert Arnold; Uwe Kordes; Ulrich Dührsen; Reinhard Schneppenheim; Reiner Siebert
Recurrent loss, but lack of mutations, of the SMARCB1 tumor suppressor gene in T-cell prolymphocytic leukemia with TCL1A-TCRAD juxtaposition.
Cancer genetics and cytogenetics 2009;192(1):44-7.
2009: Johannes H Schulte; Soyoung Lim; Alexander Schramm; Nicolaus Friedrichs; Jan Koster; Rogier Versteeg; Ingrid Øra; Kristian Pajtler; Ludger Klein-Hitpass; Steffi Kuhfittig-Kulle; Eric Metzger; Roland Schüle; Angelika Eggert; Reinhard Buettner; Jutta Kirfel
Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy.
Cancer research 2009;69(5):2065-71.
2008: Johannes H Schulte; Steffi Kuhfittig-Kulle; Ludger Klein-Hitpass; Alexander Schramm; Denis S F Biard; Petra Pfeiffer; Angelika Eggert
Expression of the TrkA or TrkB receptor tyrosine kinase alters the double-strand break (DSB) repair capacity of SY5Y neuroblastoma cells.
DNA repair 2008;7(10):1757-64.
2008: Christina A Ortmann; Lewin Eisele; Holger Nückel; Ludger Klein-Hitpass; Anja Führer; Ulrich Dührsen; Michael Zeschnigk
Aberrant hypomethylation of the cancer-testis antigen PRAME correlates with PRAME expression in acute myeloid leukemia.
Annals of hematology 2008;87(10):809-18.
2008: J Edelmann; Ludger Klein-Hitpass; A Carpinteiro; Anja Führer; Ludger Sellmann; S Stilgenbauer; U Dührsen; Jan Dürig
Bone marrow fibroblasts induce expression of PI3K/NF-kappaB pathway genes and a pro-angiogenic phenotype in CLL cells.
Leukemia research 2008;32(10):1565-72.
2008: Annemiek W Nap; Patrick G Groothuis; Chamindie Punyadeera; Ludger Klein-Hitpass; Rik Kamps; Bert Delvoux; Gerard A J Dunselman
Oral contraceptives prevent the development of endometriosis in the chicken chorioallantoic membrane model.
Contraception 2008;78(3):257-65.
2008: Adrien Daigeler; Ansgar Michael Chromik; Anne Geisler; Daniel Bulut; Christoph Hilgert; Andreas Krieg; Ludger Klein-Hitpass; Marcus Lehnhardt; Waldemar Uhl; Ulrich Mittelkötter
Synergistic apoptotic effects of taurolidine and TRAIL on squamous carcinoma cells of the esophagus.
International journal of oncology 2008;32(6):1205-20.
2008: Roland S Croner; Thomas Förtsch; Wolfgang M Brückl; Franz Rödel; Claus Rödel; Thomas Papadopoulos; Thomas Brabletz; Thomas Kirchner; Martin Sachs; Jürgen Behrens; Ludger Klein-Hitpass; Michael Stürzl; Werner Hohenberger; berthold lausen
Molecular signature for lymphatic metastasis in colorectal carcinomas.
Annals of surgery 2008;247(5):803-10.
2008: Annica Vlad; Sonja Röhrs; Ludger Klein-Hitpass; Oliver Müller
The first five years of the Wnt targetome.
Cellular signalling 2008;20(5):795-802.
2008: Steffen W Schubert; Nicolas Lamoureux; Karin Kilian; Ludger Klein-Hitpass; Said Hashemolhosseini
Identification of integrin-alpha4, Rb1, and syncytin a as murine placental target genes of the transcription factor GCMa/Gcm1.
The Journal of biological chemistry 2008;283(9):5460-5.
2008: Karen Grigo; Andrea Wirsing; Belén Lucas; Ludger Klein-Hitpass; Gerhart U Ryffel
HNF4 alpha orchestrates a set of 14 genes to down-regulate cell proliferation in kidney cells.
Biological chemistry 2008;389(2):179-87.
2008: Johannes H Schulte; Sebastian Horn; Tobias Otto; Birgit Samans; Lukas Heukamp; Ursula-Christa Eilers; Michael Krause; Kathy Astrahantseff; Ludger Klein-Hitpass; Reinhard Buettner; Alexander Schramm; Holger Christiansen; Martin Eilers; Angelika Eggert; Bernd Berwanger
MYCN regulates oncogenic MicroRNAs in neuroblastoma.
International journal of cancer. Journal international du cancer 2008;122(3):699-704.
2008: Tatjana Schilling; Robert Küffner; Ludger Klein-Hitpass; Ralf Zimmer; Franz Jakob; Norbert Schütze
Microarray analyses of transdifferentiated mesenchymal stem cells.
Journal of cellular biochemistry 2008;103(2):413-33.
2008: Adrien Daigeler; Christina Brenzel; Daniel Bulut; Anne Geisler; Christoph Hilgert; Marcus Lehnhardt; Hans U Steinau; Annegret Flier; Lars Steinstraesser; Ludger Klein-Hitpass; Ulrich Mittelkötter; Waldemar Uhl; Ansgar M Chromik
TRAIL and Taurolidine induce apoptosis and decrease proliferation in human fibrosarcoma.
Journal of experimental & clinical cancer research : CR 2008;27():82.
2008: Michael Koldehoff; Johannes L Zakrzewski; Ludger Klein-Hitpass; Dietrich W Beelen; Ahmet H Elmaagacli
Gene profiling of growth factor independence 1B gene (Gfi-1B) in leukemic cells.
International journal of hematology 2008;87(1):39-47.
2007: Denise Pargmann; Raif Yücel; Christian Kosan; Ingrid Saba; Ludger Klein-Hitpass; Simone Schimmer; Florian Heyd; Ulf Dittmer; Tarik Möröy
Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T lymphocyte function.
European journal of immunology 2007;37(12):3551-63.
2007: Hong Lu; Jian Chen; Laura Planko; Paola Zigrino; Ludger Klein-Hitpass; Thomas M Magin
Induction of inflammatory cytokines by a keratin mutation and their repression by a small molecule in a mouse model for EBS.
The Journal of investigative dermatology 2007;127(12):2781-9.
2007: Jan Dürig; S Bug; Ludger Klein-Hitpass; Tanja Boes; T Jöns; Jose I Martin-Subero; Lana Harder; Baudis Michael; Ulrich Dührsen; R Siebert
Combined single nucleotide polymorphism-based genomic mapping and global gene expression profiling identifies novel chromosomal imbalances, mechanisms and candidate genes important in the pathogenesis of T-cell prolymphocytic leukemia with inv(14)(q11q32).
Leukemia 2007;21(10):2153-63.
2007: Aurélie Hoppeler-Lebel; Claude Celati; Gemma Bellett; Mette M Mogensen; Ludger Klein-Hitpass; Michel Bornens; Anne-Marie Tassin
Centrosomal CAP350 protein stabilises microtubules associated with the Golgi complex.
Journal of cell science 2007;120(Pt 18):3299-308.
2007: Shirley K Knauer; Carolin Bier; Peter M Schlag; Johannes Fritzmann; Wolfgang Dietmaier; Franz Rödel; Ludger Klein-Hitpass; Adoriàn F Kovács; Claudia Döring; Martin-Leo Hansmann; Wolf-Karsten Hofmann; Martin Kunkel; Christoph Brochhausen; Knut Engels; Burkard M Lippert; Wolf Mann; Roland H Stauber
The survivin isoform survivin-3B is cytoprotective and can function as a chromosomal passenger complex protein.
Cell cycle (Georgetown, Tex.) 2007;6(12):1502-9.
2007: Tatjana Schilling; Ulrich Nöth; Ludger Klein-Hitpass; Franz Jakob; Norbert Schütze
Plasticity in adipogenesis and osteogenesis of human mesenchymal stem cells.
Molecular and cellular endocrinology 2007;271(1-2):1-17.
2007: Silke Erdmann; Sabine Senkel; Tanja Arndt; Belén Lucas; Jörn Lausen; Ludger Klein-Hitpass; Gerhart U Ryffel; Heike Thomas
Tissue-specific transcription factor HNF4alpha inhibits cell proliferation and induces apoptosis in the pancreatic INS-1 beta-cell line.
Biological chemistry 2007;388(1):91-106.
2007: Sandrine Gratias; Harald Rieder; Reinhard Ullmann; Ludger Klein-Hitpass; Stephanie Schneider; Réka Bölöni; Martin Kappler; Dietmar R Lohmann
Allelic loss in a minimal region on chromosome 16q24 is associated with vitreous seeding of retinoblastoma.
Cancer research 2007;67(1):408-16.
2007: Shirley K Knauer; Oliver H Krämer; Thomas Knösel; Knut Engels; Franz Rödel; Adorján F Kovács; Wolfgang Dietmaier; Ludger Klein-Hitpass; Negusse Habtemichael; Andrea Schweitzer; Jürgen Brieger; Claus Rödel; Wolf Mann; Iver Petersen; Thorsten Heinzel; Roland H Stauber
Nuclear export is essential for the tumor-promoting activity of survivin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(1):207-16.
2007: L Eisele; Ludger Klein-Hitpass; N Chatzimanolis; Bertram Opalka; Tanja Boes; Siegfried Seeber; Thomas Moritz; Michael Flasshove
Differential expression of drug-resistance-related genes between sensitive and resistant blasts in acute myeloid leukemia.
Acta haematologica 2007;117(1):8-15.
2006: Andreas Hüttmann; Ludger Klein-Hitpass; Jürgen Thomale; R Deenen; A Carpinteiro; Holger Nückel; Peter Ebeling; Anja Führer; J Edelmann; Ludger Sellmann; Ulrich Dührsen; Jan Dürig
Gene expression signatures separate B-cell chronic lymphocytic leukaemia prognostic subgroups defined by ZAP-70 and CD38 expression status.
Leukemia 2006;20(10):1774-82.
2006: Hannah J Welters; Sabine Senkel; Ludger Klein-Hitpass; Silke Erdmann; Heike Thomas; Lorna W Harries; Ewan R Pearson; Coralie Bingham; Andrew T Hattersley; Gerhart U Ryffel; Noel G Morgan
Conditional expression of hepatocyte nuclear factor-1beta, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic beta-cells.
The Journal of endocrinology 2006;190(1):171-81.
2006: Andreas Hüttmann; Ulrich Dührsen; Katja Heydarian; Ludger Klein-Hitpass; Tanja Boes; Andrew W Boyd; Chung-Leung Li
Gene expression profiles in murine hematopoietic stem cells revisited: analysis of cDNA libraries reveals high levels of translational and metabolic activities.
Stem cells (Dayton, Ohio) 2006;24(7):1719-27.
2006: Holger Nückel; Andreas Hüttmann; Ludger Klein-Hitpass; Roland Schroers; Anja Führer; Ludger Sellmann; Ulrich Dührsen; Jan Dürig
Lipoprotein lipase expression is a novel prognostic factor in B-cell chronic lymphocytic leukemia.
Leukemia & lymphoma 2006;47(6):1053-61.
2006: Tomke U Bracker; Bernd Giebel; Jan Spanholtz; Ursula R Sorg; Ludger Klein-Hitpass; Thomas Moritz; Jürgen Thomale
Stringent regulation of DNA repair during human hematopoietic differentiation: a gene expression and functional analysis.
Stem cells (Dayton, Ohio) 2006;24(3):722-30.
2005: Sabine Senkel; Belén Lucas; Ludger Klein-Hitpass; Gerhart U Ryffel
Identification of target genes of the transcription factor HNF1beta and HNF1alpha in a human embryonic kidney cell line.
Biochimica et biophysica acta 2005;1731(3):179-90.
2005: Alexander Schramm; Johannes H Schulte; Ludger Klein-Hitpass; Werner Havers; Hauke Sieverts; Bernd Berwanger; Holger Christiansen; Patrick Warnat; Benedikt Brors; Jürgen Eils; Roland Eils; Angelika Eggert
Prediction of clinical outcome and biological characterization of neuroblastoma by expression profiling.
Oncogene 2005;24(53):7902-12.
2005: Corinna Grasemann; Sandrine Gratias; Harald Stephan; Andreas Schüler; Alexander Schramm; Ludger Klein-Hitpass; Harald Rieder; Stephanie Schneider; Ferdinand Kappes; Angelika Eggert; Dietmar R Lohmann
Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma.
Oncogene 2005;24(42):6441-9.
2005: Belén Lucas; Karen Grigo; Silke Erdmann; Jörn Lausen; Ludger Klein-Hitpass; Gerhart U Ryffel
HNF4alpha reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma.
Oncogene 2005;24(42):6418-31.
2005: Roland S Croner; Andrea Peters; Wolfgang M Brueckl; Klaus E Matzel; Ludger Klein-Hitpass; Thomas Brabletz; Thomas Papadopoulos; Werner Hohenberger; Bertram Reingruber; berthold lausen
Microarray versus conventional prediction of lymph node metastasis in colorectal carcinoma.
Cancer 2005;104(2):395-404.
2005: Roland S Croner; Thomas Foertsch; Wolfgang M Brueckl; Klaus Guenther; Renate Siebenhaar; Christian Stremmel; Klaus E Matzel; Thomas Papadopoulos; Thomas Kirchner; Jürgen Behrens; Ludger Klein-Hitpass; Michael Stuerzl; Werner Hohenberger; Bertram Reingruber
Common denominator genes that distinguish colorectal carcinoma from normal mucosa.
International journal of colorectal disease 2005;20(4):353-62.
2005: Roland Schroers; Frank Griesinger; Lorenz Trümper; Detlef Haase; Bettina Kulle; Ludger Klein-Hitpass; Ludger Sellmann; Ulrich Dührsen; Jan Dürig
Combined analysis of ZAP-70 and CD38 expression as a predictor of disease progression in B-cell chronic lymphocytic leukemia.
Leukemia 2005;19(5):750-8.
2005: Slava Ziegler; Sonja Röhrs; Lara Tickenbrock; Tarik Möröy; Ludger Klein-Hitpass; Ingrid R Vetter; Oliver Müller
Novel target genes of the Wnt pathway and statistical insights into Wnt target promoter regulation.
The FEBS journal 2005;272(7):1600-15.
2005: Ahmet H Elmaagacli; Michael Koldehoff; Rudolf Peceny; Ludger Klein-Hitpass; Hellmut D Ottinger; Dietrich W Beelen; Bertram Opalka
WT1 and BCR-ABL specific small interfering RNA have additive effects in the induction of apoptosis in leukemic cells.
Haematologica 2005;90(3):326-34.
2005: Johannes H Schulte; Alexander Schramm; Ludger Klein-Hitpass; Michael Klenk; Hendrika Wessels; Berthold P Hauffa; Jürgen Eils; Roland Eils; Garrett M Brodeur; Lothar Schweigerer; Werner Havers; Angelika Eggert
Microarray analysis reveals differential gene expression patterns and regulation of single target genes contributing to the opposing phenotype of TrkA- and TrkB-expressing neuroblastomas.
Oncogene 2005;24(1):165-77.
2005: Oliver Raudies; Ralf-Jürgen Kuban; Frank Hamacher; Ludger Klein-Hitpass; Oleg I Tchernitsa; Christine Sers; Hanspeter Herzel; Reinhold Schäfer
Functional analysis and secondary expression profiling of candidate genes deregulated in conjunction with oncogenic Ras signaling.
Advances in enzyme regulation 2005;45():63-84.
2005: Marcus Lehnhardt; Ludger Klein-Hitpass; Cornelius Kuhnen; Heinz-Herbert Homann; Adrien Daigeler; Hans-Ulrich Steinau; Sonja Röhrs; Laura Schnoor; Lars Steinstraesser; Oliver Mueller
Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways.
BMC cancer 2005;5():74.
2004: Hui Zeng; Raif Yücel; Christian Kosan; Ludger Klein-Hitpass; Tarik Möröy
Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells.
The EMBO journal 2004;23(20):4116-25.
2004: Ioanna-Maria Karaguni; Eleni Gourzoulidou; Mercedes Carpintero; Anette Langerak; Ludger Klein-Hitpass; Tarik Möröy; Günther Winde; Herbert Waldmann; Oliver Müller
SMAF-1 inhibits the APC/beta-catenin pathway and shows properties similar to those of the tumor suppressor protein APC.
Chembiochem : a European journal of chemical biology 2004;5(9):1267-70.
2004: Alexandra Gellhaus; Xuesen Dong; Sven Propson; Karen Maass; Ludger Klein-Hitpass; Mark Kibschull; Otto Traub; Klaus Willecke; Bernard Perbal; Stephen J Lye; Elke Winterhager
Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells.
The Journal of biological chemistry 2004;279(35):36931-42.
2004: Karen Rother; Cindy Johne; Katja Spiesbach; Ulrike Haugwitz; Katrin Tschöp; Mark Wasner; Ludger Klein-Hitpass; Tarik Möröy; Joachim Mössner; Kurt Engeland
Identification of Tcf-4 as a transcriptional target of p53 signalling.
Oncogene 2004;23(19):3376-84.
2004: Oliver Müller; Eleni Gourzoulidou; Mercedes Carpintero; Ioanna-Maria Karaguni; Anette Langerak; Christian Herrmann; Tarik Möröy; Ludger Klein-Hitpass; Herbert Waldmann
Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening.
Angewandte Chemie (International ed. in English) 2004;43(4):450-4.
2004: Jie Chen; Christoph Röcken; Ludger Klein-Hitpass; Tobias Götze; Andreas Leodolter; Peter Malfertheiner; Matthias P A Ebert
Microarray analysis of gene expression in metastatic gastric cancer cells after incubation with the methylation inhibitor 5-aza-2'-deoxycytidine.
Clinical & experimental metastasis 2004;21(5):389-97.
2004: Heike Thomas; Sabine Senkel; Silke Erdmann; Tanja Arndt; Gülüzar Turan; Ludger Klein-Hitpass; Gerhart U Ryffel
Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4alpha and HNF1beta in a pancreatic beta-cell line.
Nucleic acids research 2004;32(19):e150.
2003: Jan Dürig; Holger Nückel; M Cremer; Anja Führer; Katja Halfmeyer; J Fandrey; Tarik Möröy; Ludger Klein-Hitpass; Ulrich Dührsen
ZAP-70 expression is a prognostic factor in chronic lymphocytic leukemia.
Leukemia 2003;17(12):2426-34.
2003: Johannes H Schulte; Alexander Schramm; T Pressel; Ludger Klein-Hitpass; Bernhard Kremens; Jürgen Eils; Werner Havers; Angelika Eggert
Microarray-analysis: a new approach to study the molecular mechanisms of thermo-chemotherapy.
Klinische Pädiatrie 2003;215(6):298-302.
2003: Bernhard Horsthemke; Hülya Nazlican; Johannes Hüsing; Ludger Klein-Hitpass; Uwe Claussen; Susanne Michel; Christina Lich; Gabriele Gillessen-Kaesbach; Karin Buiting
Somatic mosaicism for maternal uniparental disomy 15 in a girl with Prader-Willi syndrome: confirmation by cell cloning and identification of candidate downstream genes.
Human molecular genetics 2003;12(20):2723-32.
2003: Raif Yücel; Holger Karsunky; Ludger Klein-Hitpass; Tarik Möröy
The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus.
The Journal of experimental medicine 2003;197(7):831-44.
2003: Jan Dürig; Holger Nückel; Andreas Hüttmann; Elisabeth Kruse; Tanja Hölter; Katja Halfmeyer; Anja Führer; Roland Rudolph; Naser Kalhori; Arnd Nusch; Silvia Deaglio; Fabio Malavasi; Tarik Möröy; Ludger Klein-Hitpass; Ulrich Dührsen
Expression of ribosomal and translation-associated genes is correlated with a favorable clinical course in chronic lymphocytic leukemia.
Blood 2003;101(7):2748-55.