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Andres Klein-Szanto

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Anna Sukhanova; Louis M Weiner; Dong-Hua Yang; Hui Zheng; Yan Zhou; Gregory P Adams; Tetyana Bagnyukova; Barbara Burtness; Kathy Q Cai; David Cunningham; Brian L Egleston; Linara Gabitova; Erica A Golemis; Andrey Gorin; Gail E Herman; Richard I Kelley; Andres Klein-Szanto; Lisa Kratz; Hanqing Liu; Ranee Mehra; Anna Nikonova; Diana Restifo; Ilya G Serebriiskii; Igor Astsaturov
Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation.
Douglas B Stairs; Lauren J Bayne; Ben Rhoades; Maria E Vega; Todd J Waldron; Jiri Kalabis; Andres Klein-Szanto; Ju Seog Lee; Jonathan P Katz; J Alan Diehl; Albert B Reynolds; Robert H Vonderheide; Anil K Rustgi
Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene.
Amanda K Frank; Julia I-Ju Leu; Yan Zhou; Karthik Devarajan; Tatiana Nedelko; Andres Klein-Szanto; Monica Hollstein; Maureen E Murphy
The codon 72 polymorphism of p53 regulates interaction with NF-{kappa}B and transactivation of genes involved in immunity and inflammation.

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All Publications

2013: Anna Sukhanova; Louis M Weiner; Dong-Hua Yang; Hui Zheng; Yan Zhou; Gregory P Adams; Tetyana Bagnyukova; Barbara Burtness; Kathy Q Cai; David Cunningham; Brian L Egleston; Linara Gabitova; Erica A Golemis; Andrey Gorin; Gail E Herman; Richard I Kelley; Andres Klein-Szanto; Lisa Kratz; Hanqing Liu; Ranee Mehra; Anna Nikonova; Diana Restifo; Ilya G Serebriiskii; Igor Astsaturov
Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation.
Cancer discovery 2013;3(1):96-111.
2011: Douglas B Stairs; Lauren J Bayne; Ben Rhoades; Maria E Vega; Todd J Waldron; Jiri Kalabis; Andres Klein-Szanto; Ju Seog Lee; Jonathan P Katz; J Alan Diehl; Albert B Reynolds; Robert H Vonderheide; Anil K Rustgi
Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene.
Cancer cell 2011;19(4):470-83.
2011: Amanda K Frank; Julia I-Ju Leu; Yan Zhou; Karthik Devarajan; Tatiana Nedelko; Andres Klein-Szanto; Monica Hollstein; Maureen E Murphy
The codon 72 polymorphism of p53 regulates interaction with NF-{kappa}B and transactivation of genes involved in immunity and inflammation.
Molecular and cellular biology 2011;31(6):1201-13.
2010: Maria Soledad Sosa; Cynthia Lopez-Haber; Chengfeng Yang; Hongbin Wang; Mark A Lemmon; John M Busillo; Jiansong Luo; Jeffrey L Benovic; Andres Klein-Szanto; Hiroshi Yagi; J Silvio Gutkind; Ramon E Parsons; Marcelo G Kazanietz
Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.
Molecular cell 2010;40(6):877-92.
2010: Gregor M Balaburski; Rita C Dardes; Michael Johnson; Bassem Haddad; Fang Zhu; Eric A Ross; Surojeet Sengupta; Andres Klein-Szanto; Hong Liu; Eun Sook Lee; Helen Kim; V Craig Jordan
Raloxifene-stimulated experimental breast cancer with the paradoxical actions of estrogen to promote or prevent tumor growth: a unifying concept in anti-hormone resistance.
International journal of oncology 2010;37(2):387-98.
2010: Marie-Pier Tetreault; Yizeng Yang; Jenna Travis; Qian-Chun Yu; Andres Klein-Szanto; John W Tobias; Jonathan P Katz
Esophageal squamous cell dysplasia and delayed differentiation with deletion of krüppel-like factor 4 in murine esophagus.
Gastroenterology 2010;139(1):171-81.e9.
2010: Bridget A Quinn; Fang Xiao; Laura Bickel; Lainie Martin; Xiang Hua; Andres Klein-Szanto; Denise C Connolly
Development of a syngeneic mouse model of epithelial ovarian cancer.
Journal of ovarian research 2010;3():24.
2009: Eugene Izumchenko; Mahendra K Singh; Olga V Plotnikova; Nadezhda Tikhmyanova; Joy L Little; Ilya G Serebriiskii; Sachiko Seo; Mineo Kurokawa; Brian L Egleston; Andres Klein-Szanto; Elena N Pugacheva; Richard R Hardy; Marina Wolfson; Denise C Connolly; Erica A Golemis
NEDD9 promotes oncogenic signaling in mammary tumor development.
Cancer research 2009;69(18):7198-206.
2009: Yuwaraj Kadariya; Bu Yin; Baiqing Tang; Susan A Shinton; Eoin P Quinlivan; Xiang Hua; Andres Klein-Szanto; Tahseen Al-Saleem; Craig H Bassing; Richard R Hardy; warren kruger
Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma.
Cancer research 2009;69(14):5961-9.
2009: T R Hartman; Emmanuelle Nicolas; Andres Klein-Szanto; Tahseen Al-Saleem; T P Cash; M Celeste Simon; Elizabeth Petri Henske
The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis.
Oncogene 2009;28(13):1594-604.
2009: Sapna Gupta; Jirko Kühnisch; Aladdin Mustafa; Sarka Lhotak; Alexander Schlachterman; Michael J Slifker; Andres Klein-Szanto; Katherine A High; Richard C Austin; warren kruger
Mouse models of cystathionine beta-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(3):883-93.
2008: Mercedes Lioni; Kazuhiro Noma; Andrew R Snyder; Andres Klein-Szanto; J Alan Diehl; Anil K Rustgi; Meenhard Herlyn; Keiran Smalley
Bortezomib induces apoptosis in esophageal squamous cell carcinoma cells through activation of the p38 mitogen-activated protein kinase pathway.
Molecular cancer therapeutics 2008;7(9):2866-75.
2008: Douglas B Stairs; Hiroshi Nakagawa; Andres Klein-Szanto; Shukriyyah D Mitchell; Debra G Silberg; John W Tobias; John P Lynch; Anil K Rustgi
Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett's esophagus.
PloS one 2008;3(10):e3534.
2007: Ren-Huan Xu; Min Fang; Andres Klein-Szanto; Luis J Sigal
Memory CD8+ T cells are gatekeepers of the lymph node draining the site of viral infection.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(26):10992-7.
2007: Kenji Oyama; Takaomi Okawa; Hiroshi Nakagawa; Munenori Takaoka; Claudia D Andl; Seok-Hyun Kim; Andres Klein-Szanto; J Alan Diehl; Meenhard Herlyn; Wafik S El-Deiry; Anil K Rustgi
AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture.
Oncogene 2007;26(16):2353-64.
2007: Wan-Lin Yang; Kathy Qi Cai; Jennifer L Smedberg; Elizabeth Smith; Andres Klein-Szanto; Thomas C Hamilton; Xiangxi Xu
A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumor phenotype in Wv mice.
The American journal of pathology 2007;170(4):1325-36.
2007: Seiji Mabuchi; Deborah A Altomare; Denise C Connolly; Andres Klein-Szanto; Samuel Litwin; Matthew K Hoelzle; Harvey H Hensley; Thomas C Hamilton; Joseph R Testa
RAD001 (Everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer.
Cancer research 2007;67(6):2408-13.
2007: Leonard R Henry; Hyung-Ok Lee; John S Lee; Andres Klein-Szanto; Perry Watts; Eric A Ross; Wen-Tien Chen; Jonathan D Cheng
Clinical implications of fibroblast activation protein in patients with colon cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(6):1736-41.
2007: Nicole Yeager; Andres Klein-Szanto; Shioko Kimura; Antonio Di Cristofano
Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis.
Cancer research 2007;67(3):959-66.
2007: Edward R Sauter; Colette Wagner-Mann; Hormoz Ehya; Andres Klein-Szanto
Biologic markers of breast cancer in nipple aspirate fluid and nipple discharge are associated with clinical findings.
Cancer detection and prevention 2007;31(1):50-8.
2007: Martin G Belinsky; Ping Guo; Kun Lee; Feng Zhou; Elena Kotova; Alex Grinberg; Heiner Westphal; Irina Shchaveleva; Andres Klein-Szanto; James M Gallo; Gary Kruh
Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage.
Cancer research 2007;67(1):262-8.
2006: Kathy Qi Cai; Andres Klein-Szanto; Devarajan Karthik; Mitchell I Edelson; Mary B Daly; Robert F Ozols; Henry T Lynch; Andrew K Godwin; Xiangxi Xu
Age-dependent morphological alterations of human ovaries from populations with and without BRCA mutations.
Gynecologic oncology 2006;103(2):719-28.
2006: Claudia D Andl; Brenton B Fargnoli; Takaomi Okawa; Mark Bowser; Munenori Takaoka; Hiroshi Nakagawa; Andres Klein-Szanto; Xianxin Hua; Meenhard Herlyn; Anil K Rustgi
Coordinated functions of E-cadherin and transforming growth factor beta receptor II in vitro and in vivo.
Cancer research 2006;66(20):9878-85.
2006: Dong-Hua Yang; Zia Fazili; Elizabeth Smith; Kathy Qi Cai; Andres Klein-Szanto; Cynthia Cohen; Ira R Horowitz; Xiangxi Xu
Disabled-2 heterozygous mice are predisposed to endometrial and ovarian tumorigenesis and exhibit sex-biased embryonic lethality in a p53-null background.
The American journal of pathology 2006;169(1):258-67.
2006: Anna Vilgelm; Zenglin Lian; Hong Wang; Stephen L Beauparlant; Andres Klein-Szanto; Lora Hedrick Ellenson; Antonio Di Cristofano
Akt-mediated phosphorylation and activation of estrogen receptor alpha is required for endometrial neoplastic transformation in Pten+/- mice.
Cancer research 2006;66(7):3375-80.
2005: Jay E Johnson; Robert J Varkonyi; Jaclyn Schwalm; Ryan Cragle; Andres Klein-Szanto; Arthur S Patchefsky; Edna Cukierman; Margaret von Mehren; Dominique Broccoli
Multiple mechanisms of telomere maintenance exist in liposarcomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(15):5347-55.
2005: Liqun Wang; Xulin Chen; Baiqing Tang; Xiang Hua; Andres Klein-Szanto; warren kruger
Expression of mutant human cystathionine beta-synthase rescues neonatal lethality but not homocystinuria in a mouse model.
Human molecular genetics 2005;14(15):2201-8.
2005: Martin G Belinsky; Paul A Dawson; Irina Shchaveleva; Lisa J Bain; Renxue Wang; Victor Ling; Zhe-Sheng Chen; Alex Grinberg; Heiner Westphal; Andres Klein-Szanto; Anthony Lerro; Gary Kruh
Analysis of the in vivo functions of Mrp3.
Molecular pharmacology 2005;68(1):160-8.
2005: Ying Yu; Yan Cheng; Jinjin Fan; Xin-Sheng Chen; Andres Klein-Szanto; garret fitzgerald; Colin D Funk
Differential impact of prostaglandin H synthase 1 knockdown on platelets and parturition.
The Journal of clinical investigation 2005;115(4):986-95.
2005: Hong Wu; Alan Barusevicius; James Babb; Andres Klein-Szanto; A Godwin; Rosalie Elenitsas; Joel M Gelfand; Stuart R Lessin; John T Seykora
Pleiotrophin expression correlates with melanocytic tumor progression and metastatic potential.
Journal of cutaneous pathology 2005;32(2):125-30.
2004: Sherri L Stewart; Troy D Querec; Alexander R Ochman; Briana N Gruver; Rudi Bao; James S Babb; Thang S Wong; Theodoros Koutroukides; Aaron D Pinnola; Andres Klein-Szanto; Thomas C Hamilton; Christos Patriotis
Characterization of a carcinogenesis rat model of ovarian preneoplasia and neoplasia.
Cancer research 2004;64(22):8177-83.
2004: Enkhtsetseg Purev; Dewei Cai; Eric Miller; Rolf Swoboda; Ted Mayer; Andres Klein-Szanto; Francesco M Marincola; Rosemarie Mick; Laszlo Otvos; William H Wunner; Brigitte Birebent; Rajasekharan Somasundaram; Carol J Wikstrand; Darell D Bigner; Angela DeMichele; Geza Acs; Jesse A Berlin; Dorothee Herlyn
Immune responses of breast cancer patients to mutated epidermal growth factor receptor (EGF-RvIII, Delta EGF-R, and de2-7 EGF-R).
Journal of immunology (Baltimore, Md. : 1950) 2004;173(10):6472-80.
2004: binaifer Balsara; Jianming Pei; Yasuhiro Mitsuuchi; Robert Page; Andres Klein-Szanto; Hao Wang; Michael Unger; Joseph R Testa
Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions.
Carcinogenesis 2004;25(11):2053-9.
2004: Edward R Sauter; Andres Klein-Szanto; Hormoz Ehya; Brenda MacGibbon
Ductoscopic cytology and image analysis to detect breast carcinoma.
Cancer 2004;101(6):1283-92.
2004: Rachel Krassenstein; Edward R Sauter; Essel Dulaimi; Cristina Battagli; Hormoz Ehya; Andres Klein-Szanto; Paul Cairns
Detection of breast cancer in nipple aspirate fluid by CpG island hypermethylation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(1 Pt 1):28-32.
2003: Daniel E Bassi; Haleh Mahloogi; Ricardo Lopez De Cicco; Andres Klein-Szanto
Increased furin activity enhances the malignant phenotype of human head and neck cancer cells.
The American journal of pathology 2003;162(2):439-47.
2003: Robert F Ozols; Mary B Daly; Andres Klein-Szanto; Thomas C Hamilton; Robert C Bast; Molly Brewer
Specific keynote: chemoprevention of ovarian cancer: the journey begins.
Gynecologic oncology 2003;88(1 Pt 2):S59-66; discussion S67-70.
2001: Govindasamy Amuthan; Gopa Biswas; S Y Zhang; Andres Klein-Szanto; Camasamudram Vijayasarathy; Narayan G Avadhani
Mitochondria-to-nucleus stress signaling induces phenotypic changes, tumor progression and cell invasion.
The EMBO journal 2001;20(8):1910-20.
2000: Nancy A Young; Hormoz Ehya; Andres Klein-Szanto; Samuel Litwin; Mitchell R Smith; Tahseen Al-Saleem
Differentiating large cell lymphoma from indolent small B-cell lymphoma in fine needle aspirates using p53, PCNA and transformed lymphocyte count.
Acta cytologica 2000;44(4):592-603.
1999: Edward R Sauter; Hormoz Ehya; James Babb; E Diamandis; Mary Daly; Andres Klein-Szanto; Elin R Sigurdson; J Hoffman; John Malick; Paul F Engstrom
Biological markers of risk in nipple aspirate fluid are associated with residual cancer and tumour size.
British journal of cancer 1999;81(7):1222-7.
1999: T L Plank; H Logginidou; Andres Klein-Szanto; Elizabeth Petri Henske
The expression of hamartin, the product of the TSC1 gene, in normal human tissues and in TSC1- and TSC2-linked angiomyolipomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1999;12(5):539-45.
1999: Edward R Sauter; M Nesbit; J C Watson; Andres Klein-Szanto; Samuel Litwin; Meenhard Herlyn
Vascular endothelial growth factor is a marker of tumor invasion and metastasis in squamous cell carcinomas of the head and neck.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(4):775-82.
1998: T Lifsted; TE Le Voyer; M Williams; W Muller; Andres Klein-Szanto; K H Buetow; Kent W Hunter
Identification of inbred mouse strains harboring genetic modifiers of mammary tumor age of onset and metastatic progression.
International journal of cancer. Journal international du cancer 1998;77(4):640-4.
1998: Jianguo Ma; Z L Fei; Andres Klein-Szanto; James M Gallo
Modulation of angiogenesis by human glioma xenograft models that differentially express vascular endothelial growth factor.
Clinical & experimental metastasis 1998;16(6):559-68.
1997: Raymond S Yeung; C D Katsetos; Andres Klein-Szanto
Subependymal astrocytic hamartomas in the Eker rat model of tuberous sclerosis.
The American journal of pathology 1997;151(5):1477-86.
1997: Edward R Sauter; Eric Ross; Mary Daly; Andres Klein-Szanto; Paul F Engstrom; A Sorling; John Malick; Hormoz Ehya
Nipple aspirate fluid: a promising non-invasive method to identify cellular markers of breast cancer risk.
British journal of cancer 1997;76(4):494-501.