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Bruce Klein

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René M Roy; Ron Sorkness; Alana Sterkel; Marcel Wüthrich; David Gasper; Som G Nanjappa; Hugo C Paes; Bruce S Klein
Complement component 3C3 and C3a receptor are required in chitin-dependent allergic sensitization to Aspergillus fumigatus but dispensable in chitin-induced innate allergic inflammation.
Wenjun Li; Sharadha Sakthikumar; Thomas D Sullivan; Eric Walton; Anna Floyd Averette; Christina A Cuomo; Bruce S Klein; Joseph Heitman
Identification of the mating-type (MAT) locus that controls sexual reproduction of Blastomyces dermatitidis.
René M Roy; Marcel Wüthrich; Bruce S Klein
Chitin elicits CCL2 from airway epithelial cells and induces CCR2-dependent innate allergic inflammation in the lung.

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2013: René M Roy; Ron Sorkness; Alana Sterkel; Marcel Wüthrich; David Gasper; Som G Nanjappa; Hugo C Paes; Bruce S Klein
Complement component 3C3 and C3a receptor are required in chitin-dependent allergic sensitization to Aspergillus fumigatus but dispensable in chitin-induced innate allergic inflammation.
mBio 2013;4(2):.
2013: Wenjun Li; Sharadha Sakthikumar; Thomas D Sullivan; Eric Walton; Anna Floyd Averette; Christina A Cuomo; Bruce S Klein; Joseph Heitman
Identification of the mating-type (MAT) locus that controls sexual reproduction of Blastomyces dermatitidis.
Eukaryotic cell 2013;12(1):109-17.
2012: René M Roy; Marcel Wüthrich; Bruce S Klein
Chitin elicits CCL2 from airway epithelial cells and induces CCR2-dependent innate allergic inflammation in the lung.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(5):2545-52.
2012: René M Roy; Bruce S Klein
Dendritic cells in antifungal immunity and vaccine design.
Cell host & microbe 2012;11(5):436-46.
2012: Marcel Wüthrich; Thomas Sullivan; Karen Ersland; Kevin Galles; Bruce S Klein
Fungi subvert vaccine T cell priming at the respiratory mucosa by preventing chemokine-induced influx of inflammatory monocytes.
Immunity 2012;36(4):680-92.
2012: Marcel Wüthrich; Meghan B Brennan; Karen Ersland; Hanna I Filutowicz; Christopher A Frye; Benjamin H Gern; Keegan D Korthauer; Kevin O'Brien; John C Pick-Jacobs; Stacey Schultz-Cherry; Thomas D Sullivan; Bruce S Klein
Limited model antigen expression by transgenic fungi induces disparate fates during differentiation of adoptively transferred T cell receptor transgenic CD4+ T cells: robust activation and proliferation with weak effector function during recall.
Infection and immunity 2012;80(2):787-97.
2012: Som Gowda Nanjappa; Marcel Wüthrich; David Joseph Gasper; Erika Heninger; Bruce S Klein
Tc17 cells mediate vaccine immunity against lethal fungal pneumonia in immune deficient hosts lacking CD4+ T cells.
PLoS pathogens 2012;8(7):e1002771.
2012: Brad Tebbets; David Andes; Stephanie Lawry; Andre Nantel; Jeniel Nett; Douglas Stewart; Bruce S Klein
Identification and characterization of antifungal compounds using a Saccharomyces cerevisiae reporter bioassay.
PloS one 2012;7(5):e36021.
2011: Chiung-Yu Hung; Bruce S Klein; Marcel Wüthrich; Angel Gonzalez; Garry T Cole
Vaccine immunity to coccidioidomycosis occurs by early activation of three signal pathways of T helper cell response (Th1, Th2, and Th17).
Infection and immunity 2011;79(11):4511-22.
2011: Marcel Wüthrich; John C Pick-Jacobs; Garry T Cole; Hanna I Filutowicz; Kevin J Galles; Ben H Gern; Chiung Yu Hung; Bruce S Klein
A TCR transgenic mouse reactive with multiple systemic dimorphic fungi.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(3):1421-31.
2011: Nicole M Rocco; John C Carmen; Bruce S Klein
Blastomyces dermatitidis yeast cells inhibit nitric oxide production by alveolar macrophage inducible nitric oxide synthase.
Infection and immunity 2011;79(6):2385-95.
2011: John R Pfister; Kurt D Reed; Thomas D Sullivan; L Joseph Wheat; Jennifer L Anderson; John R Archer; Tammi Boers; Joshua W Burgess; Shelly Hersil; Bruce S Klein; Jennifer K Meece; Jeffrey P Davis
Non-rural point source blastomycosis outbreak near a yard waste collection site.
Clinical medicine & research 2011;9(2):57-65.
2011: Marcel Wüthrich; Theerapong Krajaejun; Valerie Shearn-Bochsler; Chris Bass; Hanna I Filutowicz; Alfred M Legendre; Bruce S Klein
Safety, tolerability, and immunogenicity of a recombinant, genetically engineered, live-attenuated vaccine against canine blastomycosis.
Clinical and vaccine immunology : CVI 2011;18(5):783-9.
2010: Karen Ersland; Marcel Wüthrich; Bruce S Klein
Dynamic interplay among monocyte-derived, dermal, and resident lymph node dendritic cells during the generation of vaccine immunity to fungi.
Cell host & microbe 2010;7(6):474-87.
2010: Theerapong Krajaejun; Marcel Wüthrich; Gregory M Gauthier; Thomas F Warner; Thomas D Sullivan; Bruce S Klein
Discordant influence of Blastomyces dermatitidis yeast-phase-specific gene BYS1 on morphogenesis and virulence.
Infection and immunity 2010;78(6):2522-8.
2010: Gregory M Gauthier; Thomas D Sullivan; Sergio S Gallardo; T Tristan Brandhorst; Amber J Vanden Wymelenberg; Christina A Cuomo; Garret Suen; Cameron R Currie; Bruce S Klein
SREB, a GATA transcription factor that directs disparate fates in Blastomyces dermatitidis including morphogenesis and siderophore biosynthesis.
PLoS pathogens 2010;6(4):e1000846.
2008: Nicole M Cooney; Bruce S Klein
Fungal adaptation to the mammalian host: it is a new world, after all.
Current opinion in microbiology 2008;11(6):511-6.
2007: Gregory M Gauthier; N Safdar; Bruce S Klein; D R Andes
Blastomycosis in solid organ transplant recipients.
Transplant infectious disease : an official journal of the Transplantation Society 2007;9(4):310-7.
2007: Bruce S Klein; Brad Tebbets
Dimorphism and virulence in fungi.
Current opinion in microbiology 2007;10(4):314-9.
2007: T Krajaejun; Gregory M Gauthier; C A Rappleye; Thomas D Sullivan; Bruce S Klein
Development and application of a green fluorescent protein sentinel system for identification of RNA interference in Blastomyces dermatitidis illuminates the role of septin in morphogenesis and sporulation.
Eukaryotic cell 2007;6(8):1299-309.
2007: Julie C Nemecek; Marcel Wüthrich; Bruce S Klein
Detection and measurement of two-component systems that control dimorphism and virulence in fungi.
Methods in enzymology 2007;422():465-87.
2007: Jim E Cutler; George S Deepe; Bruce S Klein
Advances in combating fungal diseases: vaccines on the threshold.
Nature reviews. Microbiology 2007;5(1):13-28.
2007: Marcel Wüthrich; Hanna I Filutowicz; Holly L Allen; George S Deepe; Bruce S Klein
V beta1+ J beta1.1+/V alpha2+ J alpha49+ CD4+ T cells mediate resistance against infection with Blastomyces dermatitidis.
Infection and immunity 2007;75(1):193-200.
2006: Marcel Wüthrich; Philip L Fisette; Hanna I Filutowicz; Bruce S Klein
Differential requirements of T cell subsets for CD40 costimulation in immunity to Blastomyces dermatitidis.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(9):5538-47.
2006: Julie C Nemecek; Marcel Wüthrich; Bruce S Klein
Global control of dimorphism and virulence in fungi.
Science (New York, N.Y.) 2006;312(5773):583-8.
2006: Marcel Wüthrich; Beatriz Finkel-Jimenez; T Tristan Brandhorst; Hanna I Filutowicz; Thomas Warner; Bruce S Klein
Analysis of non-adhesive pathogenic mechanisms of BAD1 on Blastomyces dermatitidis.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2006;44(1):41-9.
2005: T Tristan Brandhorst; Gregory M Gauthier; Richard A Stein; Bruce S Klein
Calcium binding by the essential virulence factor BAD-1 of Blastomyces dermatitidis.
The Journal of biological chemistry 2005;280(51):42156-63.
2005: Marcel Wüthrich; Thomas Warner; Bruce S Klein
CD28 is required for optimal induction, but not maintenance, of vaccine-induced immunity to Blastomyces dermatitidis.
Infection and immunity 2005;73(11):7436-41.
2005: Marcel Wüthrich; Thomas Warner; Bruce S Klein
IL-12 is required for induction but not maintenance of protective, memory responses to Blastomyces dermatitidis: implications for vaccine development in immune-deficient hosts.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):5288-97.
2005: George S Deepe; Marcel Wüthrich; Bruce S Klein
Progress in vaccination for histoplasmosis and blastomycosis: coping with cellular immunity.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2005;43(5):381-9.
2004: T Tristan Brandhorst; Marcel Wüthrich; Beatriz Finkel-Jimenez; Thomas Warner; Bruce S Klein
Exploiting type 3 complement receptor for TNF-alpha suppression, immune evasion, and progressive pulmonary fungal infection.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(12):7444-53.
2004: Peggy J Rooney; Bruce S Klein
Sequence elements necessary for transcriptional activation of BAD1 in the yeast phase of Blastomyces dermatitidis.
Eukaryotic cell 2004;3(3):785-94.
2003: Marcel Wuthrich; Hanna I Filutowicz; Thomas Warner; George S Deepe; Bruce S Klein
Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells: implications for vaccine development in immune-deficient hosts.
The Journal of experimental medicine 2003;197(11):1405-16.
2002: Marcel Wüthrich; Hanna I Filutowicz; Thomas Warner; Bruce S Klein
Requisite elements in vaccine immunity to Blastomyces dermatitidis: plasticity uncovers vaccine potential in immune-deficient hosts.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(12):6969-76.
2002: Thomas D Sullivan; Peggy J Rooney; Bruce S Klein
Agrobacterium tumefaciens integrates transfer DNA into single chromosomal sites of dimorphic fungi and yields homokaryotic progeny from multinucleate yeast.
Eukaryotic cell 2002;1(6):895-905.
2002: Beatriz Finkel-Jimenez; Marcel Wüthrich; Bruce S Klein
BAD1, an essential virulence factor of Blastomyces dermatitidis, suppresses host TNF-alpha production through TGF-beta-dependent and -independent mechanisms.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(11):5746-55.
2002: Peggy J Rooney; Bruce S Klein
Linking fungal morphogenesis with virulence.
Cellular microbiology 2002;4(3):127-37.
2002: T Tristan Brandhorst; Peggy J Rooney; Thomas D Sullivan; Bruce S Klein
Using new genetic tools to study the pathogenesis of Blastomyces dermatitidis.
Trends in microbiology 2002;10(1):25-30.
2001: Mason X Zhang; T Tristan Brandhorst; Thomas R Kozel; Bruce S Klein
Role of glucan and surface protein BAD1 in complement activation by Blastomyces dermatitidis yeast.
Infection and immunity 2001;69(12):7559-64.
2001: Beatriz Finkel-Jimenez; Marcel Wüthrich; T Tristan Brandhorst; Bruce S Klein
The WI-1 adhesin blocks phagocyte TNF-alpha production, imparting pathogenicity on Blastomyces dermatitidis.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2665-73.
2001: Peggy J Rooney; Thomas D Sullivan; Bruce S Klein
Selective expression of the virulence factor BAD1 upon morphogenesis to the pathogenic yeast form of Blastomyces dermatitidis: evidence for transcriptional regulation by a conserved mechanism.
Molecular microbiology 2001;39(4):875-89.
2000: Marcel Wüthrich; Hanna I Filutowicz; Bruce S Klein
Mutation of the WI-1 gene yields an attenuated blastomyces dermatitidis strain that induces host resistance.
The Journal of clinical investigation 2000;106(11):1381-9.
2000: Marcel Wüthrich; B E Finkel-Jiminez; Bruce S Klein
Interleukin 12 as an adjuvant to WI-1 adhesin immunization augments delayed-type hypersensitivity, shifts the subclass distribution of immunoglobulin G antibodies, and enhances protective immunity to Blastomyces dermatitidis infection.
Infection and immunity 2000;68(12):7172-4.
2000: Bruce S Klein
Microbiology. Turning up the heat on Histoplasma capsulatum.
Science (New York, N.Y.) 2000;290(5495):1311-2.
2000: Bruce S Klein
Molecular basis of pathogenicity in Blastomyces dermatitidis: the importance of adhesion.
Current opinion in microbiology 2000;3(4):339-43.
2000: Marcel Wüthrich; Bruce S Klein
Investigation of anti-WI-1 adhesin antibody-mediated protection in experimental pulmonary blastomycosis.
The Journal of infectious diseases 2000;181(5):1720-8.
2000: Bruce S Klein; R A Squires; J K Lloyd; D R Ruge; A M Legendre
Canine antibody response to Blastomyces dermatitidis WI-1 antigen.
American journal of veterinary research 2000;61(5):554-8.
2000: Wun-Ling Chang; R G Audet; B D Aizenstein; Laura H Hogan; R I DeMars; Bruce S Klein
T-Cell epitopes and human leukocyte antigen restriction elements of an immunodominant antigen of Blastomyces dermatitidis.
Infection and immunity 2000;68(2):502-10.
1998: Marcel Wüthrich; Wun-Ling Chang; Bruce S Klein
Immunogenicity and protective efficacy of the WI-1 adhesin of Blastomyces dermatitidis.
Infection and immunity 1998;66(11):5443-9.
1998: Wun-Ling Chang; Henri C Van Der Heyde; Bruce S Klein
Flow cytometric quantitation of yeast a novel technique for use in animal model work and in vitro immunologic assays.
Journal of immunological methods 1998;211(1-2):51-63.
1997: Bruce S Klein
Role of cell surface molecules of Blastomyces dermatitidis in the pathogenesis and immunobiology of blastomycosis.
Seminars in respiratory infections 1997;12(3):198-205.
1997: Bruce S Klein; B D Aizenstein; Laura H Hogan
African strains of Blastomyces dermatitidis that do not express surface adhesin WI-1.
Infection and immunity 1997;65(4):1505-9.
1997: Laura H Hogan; Bruce S Klein
Transforming DNA integrates at multiple sites in the dimorphic fungal pathogen Blastomyces dermatitidis.
Gene 1997;186(2):219-26.
1996: Laura H Hogan; Bruce S Klein; S M Levitz
Virulence factors of medically important fungi.
Clinical microbiology reviews 1996;9(4):469-88.
1996: Bruce S Klein; Simon L Newman
Role of cell-surface molecules of Blastomyces dermatitidis in host-pathogen interactions.
Trends in microbiology 1996;4(6):246-51.
1995: Laura H Hogan; S Josvai; Bruce S Klein
Genomic cloning, characterization, and functional analysis of the major surface adhesin WI-1 on Blastomyces dermatitidis yeasts.
The Journal of biological chemistry 1995;270(51):30725-32.
1995: Simon L Newman; S Chaturvedi; Bruce S Klein
The WI-1 antigen of Blastomyces dermatitidis yeasts mediates binding to human macrophage CD11b/CD18 (CR3) and CD14.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(2):753-61.
1994: Bruce S Klein; J M Jones
Purification and characterization of the major antigen WI-1 from Blastomyces dermatitidis yeasts and immunological comparison with A antigen.
Infection and immunity 1994;62(9):3890-900.
1994: Laura H Hogan; Bruce S Klein
Altered expression of surface alpha-1,3-glucan in genetically related strains of Blastomyces dermatitidis that differ in virulence.
Infection and immunity 1994;62(8):3543-6.
1994: Bruce S Klein; S Chaturvedi; Laura H Hogan; J M Jones; Simon L Newman
Altered expression of surface protein WI-1 in genetically related strains of Blastomyces dermatitidis that differ in virulence regulates recognition of yeasts by human macrophages.
Infection and immunity 1994;62(8):3536-42.
1993: Bruce S Klein; Laura H Hogan; J M Jones
Immunologic recognition of a 25-amino acid repeat arrayed in tandem on a major antigen of Blastomyces dermatitidis.
The Journal of clinical investigation 1993;92(1):330-7.
1992: Bruce S Klein; Paul M Sondel; J M Jones
WI-1, a novel 120-kilodalton surface protein on Blastomyces dermatitidis yeast cells, is a target antigen of cell-mediated immunity in human blastomycosis.
Infection and immunity 1992;60(10):4291-300.
1991: Dennis G Maki; Bruce S Klein; R D McCormick; C J Alvarado; M A Zilz; S M Stolz; C A Hassemer; J Gould; A R Liegel
Nosocomial Pseudomonas pickettii bacteremias traced to narcotic tampering. A case for selective drug screening of health care personnel.
JAMA : the journal of the American Medical Association 1991;265(8):981-6.
1990: Bruce S Klein; R W Bradsher; J M Vergeront; Jeffrey P Davis
Development of long-term specific cellular immunity after acute Blastomyces dermatitidis infection: assessments following a large point-source outbreak in Wisconsin.
The Journal of infectious diseases 1990;161(1):97-101.
1990: Bruce S Klein; J M Jones
Isolation, purification, and radiolabeling of a novel 120-kD surface protein on Blastomyces dermatitidis yeasts to detect antibody in infected patients.
The Journal of clinical investigation 1990;85(1):152-61.
1989: Bruce S Klein; W H Perloff; Dennis G Maki
Reduction of nosocomial infection during pediatric intensive care by protective isolation.
The New England journal of medicine 1989;320(26):1714-21.
1987: Bruce S Klein; J M Vergeront; A F DiSalvo; L Kaufman; Jeffrey P Davis
Two outbreaks of blastomycosis along rivers in Wisconsin. Isolation of Blastomyces dermatitidis from riverbank soil and evidence of its transmission along waterways.
The American review of respiratory disease 1987;136(6):1333-8.
1987: Bruce S Klein; J M Vergeront; L Kaufman; R W Bradsher; U N Kumar; G Mathai; B Varkey; Jeffrey P Davis
Serological tests for blastomycosis: assessments during a large point-source outbreak in Wisconsin.
The Journal of infectious diseases 1987;155(2):262-8.
1986: Bruce S Klein; J M Vergeront; Jeffrey P Davis
Epidemiologic aspects of blastomycosis, the enigmatic systemic mycosis.
Seminars in respiratory infections 1986;1(1):29-39.
1986: Bruce S Klein; J M Vergeront; R J Weeks; U N Kumar; G Mathai; B Varkey; L Kaufman; R W Bradsher; J F Stoebig; Jeffrey P Davis
Isolation of Blastomyces dermatitidis in soil associated with a large outbreak of blastomycosis in Wisconsin.
The New England journal of medicine 1986;314(9):529-34.
1986: Bruce S Klein; J M Vergeront; Martin Blaser; P Edmonds; D J Brenner; D Janssen; Jeffrey P Davis
Campylobacter infection associated with raw milk. An outbreak of gastroenteritis due to Campylobacter jejuni and thermotolerant Campylobacter fetus subsp fetus.
JAMA : the journal of the American Medical Association 1986;255(3):361-4.