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Eugenie Kleinerman

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Krithi Rao-Bindal; John Stewart; Nadezhda V Koshkina; Eugenie S Kleinerman
The Histone Deacetylase Inhibitor, MS-275 (Entinostat), Downregulates c-FLIP, Sensitizes Osteosarcoma Cells to FasL, and Induces the Regression of Osteosarcoma Lung Metastases.
Krithi Rao-Bindal; Ling Yu; Chethan K Rao; Eugenie S Kleinerman
Expression of c-FLIP in pulmonary metastases in osteosarcoma patients and human xenografts.
Nadezhda V Koshkina; Ge Yang; Eugenie S Kleinerman
Inhibition of Cdc42-interacting protein 4 (CIP4) impairs osteosarcoma tumor progression.

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2013: Krithi Rao-Bindal; John Stewart; Nadezhda V Koshkina; Eugenie S Kleinerman
The Histone Deacetylase Inhibitor, MS-275 (Entinostat), Downregulates c-FLIP, Sensitizes Osteosarcoma Cells to FasL, and Induces the Regression of Osteosarcoma Lung Metastases.
Current cancer drug targets 2013;13(4):411-22.
2013: Krithi Rao-Bindal; Ling Yu; Chethan K Rao; Eugenie S Kleinerman
Expression of c-FLIP in pulmonary metastases in osteosarcoma patients and human xenografts.
Pediatric blood & cancer 2013;60(4):575-9.
2013: Nadezhda V Koshkina; Ge Yang; Eugenie S Kleinerman
Inhibition of Cdc42-interacting protein 4 (CIP4) impairs osteosarcoma tumor progression.
Current cancer drug targets 2013;13(1):48-56.
2012: Gangxiong Huang; Hua Wang; Zhichao Zhou; Eugenie S Kleinerman
CAPER-α alternative splicing regulates the expression of vascular endothelial growth factor₁₆₅ in Ewing sarcoma cells.
Cancer 2012;118(8):2106-16.
2012: Gangxiong Huang; Dennis Hughes; Kazumasa Nishimoto; Zhichao Zhou; Eugenie S Kleinerman
miR-20a encoded by the miR-17-92 cluster increases the metastatic potential of osteosarcoma cells by regulating Fas expression.
Cancer research 2012;72(4):908-16.
2011: Randala Hamdan; Zhichao Zhou; Eugenie S Kleinerman
SDF-1α induces PDGF-B expression and the differentiation of bone marrow cells into pericytes.
Molecular cancer research : MCR 2011;9(11):1462-70.
2011: Nadezhda V Koshkina; Krithi Rao-Bindal; Eugenie S Kleinerman
Effect of the histone deacetylase inhibitor SNDX-275 on Fas signaling in osteosarcoma cells and the feasibility of its topical application for the treatment of osteosarcoma lung metastases.
Cancer 2011;117(15):3457-67.
2011: Zhichao Zhou; Keri Schadler Stewart; Ling Yu; Eugenie S Kleinerman
Bone marrow cells participate in tumor vessel formation that supports the growth of Ewing's sarcoma in the lung.
Angiogenesis 2011;14(2):125-33.
2011: Keri Schadler Stewart; Zhichao Zhou; Patrick A Zweidler-McKay; Eugenie S Kleinerman
Delta-like ligand 4-Notch signaling regulates bone marrow-derived pericyte/vascular smooth muscle cell formation.
Blood 2011;117(2):719-26.
2011: Keri S Stewart; Eugenie S Kleinerman
Tumor Vessel Development and Expansion in Ewing's Sarcoma: A Review of the Vasculogenesis Process and Clinical Trials with Vascular-Targeting Agents.
Sarcoma 2011;2011():165837.
2011: Krithi Rao-Bindal; Eugenie S Kleinerman
Epigenetic regulation of apoptosis and cell cycle in osteosarcoma.
Sarcoma 2011;2011():679457.
2010: Yongxin Wang; Deendayal Mandal; Suizhau Wang; Eugenie S Kleinerman; Raphael E Pollock; Dina lev; Andrea Hayes-Jordan
Platelet-derived growth factor receptor beta inhibition increases tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitivity: imatinib and TRAIL dual therapy.
Cancer 2010;116(16):3892-902.
2010: Carola A S Arndt; Nadezhda V Koshkina; Carrie Y Inwards; Douglas S Hawkins; Mark Krailo; Doojduen Villaluna; Peter M Anderson; Allen M Goorin; Martin L Blakely; Mark Bernstein; Sharon A Bell; Kaylee Ray; Darryl C Grendahl; Neyssa M Marina; Eugenie S Kleinerman
Inhaled granulocyte-macrophage colony stimulating factor for first pulmonary recurrence of osteosarcoma: effects on disease-free survival and immunomodulation. a report from the Children's Oncology Group.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(15):4024-30.
2010: Nancy Gordon; Eugenie S Kleinerman
Aerosol therapy for the treatment of osteosarcoma lung metastases: targeting the Fas/FasL pathway and rationale for the use of gemcitabine.
Journal of aerosol medicine and pulmonary drug delivery 2010;23(4):189-96.
2010: Carlos O Rodriguez; Torrie A Crabbs; Dennis W Wilson; Virginia A Cannan; Katherine A Skorupski; Nancy Gordon; Nadezhda V Koshkina; Eugenie S Kleinerman; Peter M Anderson
Aerosol gemcitabine: preclinical safety and in vivo antitumor activity in osteosarcoma-bearing dogs.
Journal of aerosol medicine and pulmonary drug delivery 2010;23(4):197-206.
2010: Ling Yu; Bing Su; Mario Hollomon; Yong Deng; Valeria Facchinetti; Eugenie S Kleinerman
Vasculogenesis driven by bone marrow-derived cells is essential for growth of Ewing's sarcomas.
Cancer research 2010;70(4):1334-43.
2010: Keri L Schadler; Patrick A Zweidler-McKay; Hui Guan; Eugenie S Kleinerman
Delta-like ligand 4 plays a critical role in pericyte/vascular smooth muscle cell formation during vasculogenesis and tumor vessel expansion in Ewing's sarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(3):848-56.
2009: Emmanuelle Pradelli; Babou Karimdjee-Soilihi; Jean-François Michiels; Jean-Ehrland Ricci; Marie-Ange Millet; Fanny Vandenbos; Timothy J Sullivan; Tassie L Collins; Michael G Johnson; Julio C Medina; Eugenie S Kleinerman; Annie Schmid-Alliana; Heidy Schmid-Antomarchi
Antagonism of chemokine receptor CXCR3 inhibits osteosarcoma metastasis to lungs.
International journal of cancer. Journal international du cancer 2009;125(11):2586-94.
2009: Alexander J Chou; Eugenie S Kleinerman; Mark Krailo; Zhengjia Chen; Donna L Betcher; John Healey; Ernest U Conrad; Michael L Nieder; Michael A Weiner; Robert J Wells; Richard B Womer; Paul A Meyers
Addition of muramyl tripeptide to chemotherapy for patients with newly diagnosed metastatic osteosarcoma: a report from the Children's Oncology Group.
Cancer 2009;115(22):5339-48.
2009: Nancy Gordon; Eugenie S Kleinerman
The role of Fas/FasL in the metastatic potential of osteosarcoma and targeting this pathway for the treatment of osteosarcoma lung metastases.
Cancer treatment and research 2009;152():497-508.
2009: Hui Guan; Zhichao Zhou; Ying Cao; Xiaoping Duan; Eugenie S Kleinerman
VEGF165 promotes the osteolytic bone destruction of ewing's sarcoma tumors by upregulating RANKL.
Oncology research 2009;18(2-3):117-25.
2009: Gangxiong Huang; Nadezhda V Koshkina; Eugenie S Kleinerman
Fas expression in metastatic osteosarcoma cells is not regulated by CpG island methylation.
Oncology research 2009;18(1):31-9.
2009: Xiaoping Duan; Hui Guan; Ying Cao; Eugenie S Kleinerman
Murine bone marrow-derived mesenchymal stem cells as vehicles for interleukin-12 gene delivery into Ewing sarcoma tumors.
Cancer 2009;115(1):13-22.
2008: Krishna Reddy; Zhichao Zhou; Shu-Fang Jia; Tim H Lee; Jaime Morales-Arias; Ying Cao; Eugenie S Kleinerman
Stromal cell-derived factor-1 stimulates vasculogenesis and enhances Ewing's sarcoma tumor growth in the absence of vascular endothelial growth factor.
International journal of cancer. Journal international du cancer 2008;123(4):831-7.
2008: Nidra I Rodriguez; W Keith Hoots; Nadezhda V Koshkina; Jaime A Morales-Arias; Carola A S Arndt; Carrie Y Inwards; Douglas S Hawkins; Mark F Munsell; Eugenie S Kleinerman
COX-2 expression correlates with survival in patients with osteosarcoma lung metastases.
Journal of pediatric hematology/oncology 2008;30(7):507-12.
2008: Hui Guan; Zhichao Zhou; Gary E Gallick; Shu-Fang Jia; Jaime Morales; Anil K Sood; Seth J Corey; Eugenie S Kleinerman
Targeting Lyn inhibits tumor growth and metastasis in Ewing's sarcoma.
Molecular cancer therapeutics 2008;7(7):1807-16.
2008: Krishna Reddy; Zhichao Zhou; Keri Schadler; Shu-Fang Jia; Eugenie S Kleinerman
Bone marrow subsets differentiate into endothelial cells and pericytes contributing to Ewing's tumor vessels.
Molecular cancer research : MCR 2008;6(6):929-36.
2008: Paul A Meyers; Cindy L Schwartz; Mark Krailo; John Healey; Mark L Bernstein; Donna Betcher; William Shay Ferguson; Mark C Gebhardt; Allen M Goorin; Michael B Harris; Eugenie S Kleinerman; Michael P Link; Helen Nadel; Michael Nieder; Gene P Siegal; Michael A Weiner; Robert J Wells; Richard B Womer; Holcombe E Grier
Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival--a report from the Children's Oncology Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(4):633-8.
2008: Gerardo Quezada; Nadezhda V Koshkina; Patrick A Zweidler-McKay; Zichao Zhou; Dimitrios P Kontoyiannis; Eugenie S Kleinerman
Intranasal granulocyte-macrophage colony-stimulating factor reduces the Aspergillus burden in an immunosuppressed murine model of pulmonary aspergillosis.
Antimicrobial agents and chemotherapy 2008;52(2):716-8.
2008: Shu-Fang Jia; Hui Guan; Xiaoping Duan; Eugenie S Kleinerman
VEGF165 is necessary to the metastatic potential of Fas(-) osteosarcoma cells but will not rescue the Fas(+) cells.
Journal of experimental therapeutics & oncology 2008;7(2):89-97.
2008: Krishna Reddy; Ying Cao; Zhichao Zhou; Ling Yu; Shu-Fang Jia; Eugenie S Kleinerman
VEGF165 expression in the tumor microenvironment influences the differentiation of bone marrow-derived pericytes that contribute to the Ewing's sarcoma vasculature.
Angiogenesis 2008;11(3):257-67.
2008: Ying Cao; Shu-Fang Jia; Geetika Chakravarty; Benoit de Crombrugghe; Eugenie S Kleinerman
The osterix transcription factor down-regulates interleukin-1 alpha expression in mouse osteosarcoma cells.
Molecular cancer research : MCR 2008;6(1):119-26.
2008: Harm C A Graat; Victor W van Beusechem; Frederik H E Schagen; M Adhiambo Witlox; Eugenie S Kleinerman; Marco N Helder; Winald Gerritsen; G J L Kaspers; Paul I J M Wuisman
Intravenous administration of the conditionally replicative adenovirus Ad5-Delta24RGD induces regression of osteosarcoma lung metastases.
Molecular cancer 2008;7():9.
2007: Nadezhda V Koshkina; Eugenie S Kleinerman; Guojun Li; Chong C Zhao; Qingyi Wei; Erich M Sturgis
Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients.
Journal of pediatric hematology/oncology 2007;29(12):815-21.
2007: Zhichao Zhou; Krishna Reddy; Hui Guan; Eugenie S Kleinerman
VEGF(165), but not VEGF(189), stimulates vasculogenesis and bone marrow cell migration into Ewing's sarcoma tumors in vivo.
Molecular cancer research : MCR 2007;5(11):1125-32.
2007: Nadezhda V Koshkina; Chand Khanna; Arnulfo Mendoza; Hui Guan; Lindsey DeLauter; Eugenie S Kleinerman
Fas-negative osteosarcoma tumor cells are selected during metastasis to the lungs: the role of the Fas pathway in the metastatic process of osteosarcoma.
Molecular cancer research : MCR 2007;5(10):991-9.
2007: Jaime Morales-Arias; Paul A Meyers; Marcela F Bolontrade; Nidra Rodriguez; Zhichao Zhou; Krishna Reddy; Alexander J Chou; Nadezhda V Koshkina; Eugenie S Kleinerman
Expression of granulocyte-colony-stimulating factor and its receptor in human Ewing sarcoma cells and patient tumor specimens: potential consequences of granulocyte-colony-stimulating factor administration.
Cancer 2007;110(7):1568-77.
2007: Zhichao Zhou; Marcela F Bolontrade; Krishna Reddy; Xiaoping Duan; Hui Guan; Ling Yu; Daniel J Hicklin; Eugenie S Kleinerman
Suppression of Ewing's sarcoma tumor growth, tumor vessel formation, and vasculogenesis following anti vascular endothelial growth factor receptor-2 therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(16):4867-73.
2007: Nancy Gordon; Nadezhda V Koshkina; Shu-Fang Jia; Chand Khanna; Arnulfo Mendoza; Laura L Worth; Eugenie S Kleinerman
Corruption of the Fas pathway delays the pulmonary clearance of murine osteosarcoma cells, enhances their metastatic potential, and reduces the effect of aerosol gemcitabine.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(15 Pt 1):4503-10.
2007: Gary Potikyan; Rupert O V Savene; Julie M Gaulden; Kelly A France; Zhichao Zhou; Eugenie S Kleinerman; Stephen L Lessnick; Christopher T Denny
EWS/FLI1 regulates tumor angiogenesis in Ewing's sarcoma via suppression of thrombospondins.
Cancer research 2007;67(14):6675-84.
2007: Guillermo De Angulo; Mike Hernandez; Jaime Morales-Arias; Cynthia E Herzog; Peter Anderson; Johannes Ernst Wolff; Eugenie S Kleinerman
Early lymphocyte recovery as a prognostic indicator for high-risk Ewing sarcoma.
Journal of pediatric hematology/oncology 2007;29(1):48-52.
2006: Shu-Fang Jia; Xiaoping Duan; Laura L Worth; Hui Guan; Eugenie S Kleinerman
Intratumor murine interleukin-12 gene therapy suppressed the growth of local and distant Ewing's sarcoma.
Cancer gene therapy 2006;13(10):948-57.
2006: Tim H Lee; Marcela F Bolontrade; Laura L Worth; Hui Guan; Lee M Ellis; Eugenie S Kleinerman
Production of VEGF165 by Ewing's sarcoma cells induces vasculogenesis and the incorporation of CD34+ stem cells into the expanding tumor vasculature.
International journal of cancer. Journal international du cancer 2006;119(4):839-46.
2006: Xiaoping Duan; Shu-Fang Jia; Nadezhda V Koshkina; Eugenie S Kleinerman
Intranasal interleukin-12 gene therapy enhanced the activity of ifosfamide against osteosarcoma lung metastases.
Cancer 2006;106(6):1382-8.
2005: Zhichao Zhou; Elizabeth A Lafleur; Nadezhda V Koshkina; Laura L Worth; Malisa S Lester; Eugenie S Kleinerman
Interleukin-12 up-regulates Fas expression in human osteosarcoma and Ewing's sarcoma cells by enhancing its promoter activity.
Molecular cancer research : MCR 2005;3(12):685-91.
2005: Nancy Gordon; Carola A S Arndt; Douglas S Hawkins; Debra K Doherty; Carrie Y Inwards; Mark F Munsell; John Stewart; Nadezhda V Koshkina; Eugenie S Kleinerman
Fas expression in lung metastasis from osteosarcoma patients.
Journal of pediatric hematology/oncology 2005;27(11):611-5.
2005: Zhichao Zhou; Hui Guan; Xiaoping Duan; Eugenie S Kleinerman
Zoledronic acid inhibits primary bone tumor growth in Ewing sarcoma.
Cancer 2005;104(8):1713-20.
2005: Nadezhda V Koshkina; Eugenie S Kleinerman
Aerosol gemcitabine inhibits the growth of primary osteosarcoma and osteosarcoma lung metastases.
International journal of cancer. Journal international du cancer 2005;116(3):458-63.
2005: Zhichao Zhou; Hui Guan; Eugenie S Kleinerman
E1A specifically enhances sensitivity to topoisomerase IIalpha targeting anticancer drug by up-regulating the promoter activity.
Molecular cancer research : MCR 2005;3(5):271-5.
2005: Hui Guan; Zhichao Zhou; Hua Wang; Shu-Fang Jia; Wenbiao Liu; Eugenie S Kleinerman
A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(7):2662-9.
2005: Paul A Meyers; Cindy L Schwartz; Mark Krailo; Eugenie S Kleinerman; Donna Betcher; Mark L Bernstein; Ernest Conrad; William Shay Ferguson; Mark Gebhardt; Allen M Goorin; Michael B Harris; John Healey; Andrew G Huvos; Michael Link; Joseph F Montebello; Helen Nadel; Michael Nieder; Judith Sato; Gene Siegal; Michael Weiner; Robert Wells; Lester Wold; Richard B Womer; Holcombe E Grier
Osteosarcoma: a randomized, prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high-dose methotrexate.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(9):2004-11.
2005: Hui Guan; Shu-Fang Jia; Zhichao Zhou; John Stewart; Eugenie S Kleinerman
Herceptin down-regulates HER-2/neu and vascular endothelial growth factor expression and enhances taxol-induced cytotoxicity of human Ewing's sarcoma cells in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(5):2008-17.
2005: Ying Cao; Zhichao Zhou; Benoit de Crombrugghe; Kazuhisa Nakashima; Hui Guan; Xiaoping Duan; Shu-Fang Jia; Eugenie S Kleinerman
Osterix, a transcription factor for osteoblast differentiation, mediates antitumor activity in murine osteosarcoma.
Cancer research 2005;65(4):1124-8.
2005: Takeshi Asano; Eugenie S Kleinerman; Leonard A Zwelling; Zhichao Zhou; Yoshitaka Fukunaga
Adenovirus-mediated human topoisomerase IIalpha gene transfer increases the sensitivity of etoposide-resistant human and mouse breast cancer cells.
Acta oncologica (Stockholm, Sweden) 2005;44(3):240-7.
2004: Elizabeth A Lafleur; Nadezhda V Koshkina; John Stewart; Shu-Fang Jia; Laura L Worth; Xiaoping Duan; Eugenie S Kleinerman
Increased Fas expression reduces the metastatic potential of human osteosarcoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(23):8114-9.
2004: Xiaoping Duan; Zhichao Zhou; Shu-Fang Jia; Michael Colvin; Elizabeth A Lafleur; Eugenie S Kleinerman
Interleukin-12 enhances the sensitivity of human osteosarcoma cells to 4-hydroperoxycyclophosphamide by a mechanism involving the Fas/Fas-ligand pathway.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(2):777-83.
2004: Xiaoping Duan; Shu-Fang Jia; Zhichao Zhou; Robert R Langley; Marcela F Bolontrade; Eugenie S Kleinerman
Association of alphavbeta3 integrin expression with the metastatic potential and migratory and chemotactic ability of human osteosarcoma cells.
Clinical & experimental metastasis 2004;21(8):747-53.
2003: Zhichao Zhou; Rong-Rong Zhou; Hui Guan; Corazon D Bucana; Eugenie S Kleinerman
E1A gene therapy inhibits angiogenesis in a Ewing's sarcoma animal model.
Molecular cancer therapeutics 2003;2(12):1313-9.
2003: Shu-Fang Jia; Laura L Worth; Charles L Densmore; Bo Xu; Xiaoping Duan; Eugenie S Kleinerman
Aerosol gene therapy with PEI: IL-12 eradicates osteosarcoma lung metastases.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(9):3462-8.
2003: Rex A W Marco; C Marcela Díaz-Montero; James N Wygant; Eugenie S Kleinerman; Bradley W McIntyre
Alpha 4 integrin increases anoikis of human osteosarcoma cells.
Journal of cellular biochemistry 2003;88(5):1038-47.
2003: Shu-Fang Jia; Rong-Rong Zhou; Eugenie S Kleinerman
Nude mouse lung metastases models of osteosarcoma and Ewing's sarcoma for evaluating new therapeutic strategies.
Methods in molecular medicine 2003;74():495-505.
2003: Ajay Gautam; J Clifford Waldrep; Eugenie S Kleinerman; Bo Xu; Yuen-Kai Fung; Anne T'Ang; Charles L Densmore
Aerosol gene therapy for metastatic lung cancer using PEI-p53 complexes.
Methods in molecular medicine 2003;75():607-18.
2002: Marcela F Bolontrade; Rong-Rong Zhou; Eugenie S Kleinerman
Vasculogenesis Plays a Role in the Growth of Ewing's Sarcoma in Vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(11):3622-7.
2002: Laura L Worth; Elizabeth A Lafleur; Shu-Fang Jia; Eugenie S Kleinerman
Fas expression inversely correlates with metastatic potential in osteosarcoma cells.
Oncology reports 2002;9(4):823-7.
2002: Rong-Rong Zhou; Shu-Fang Jia; Zhichao Zhou; Yunfang Wang; Corazon D Bucana; Eugenie S Kleinerman
Adenovirus-E1A gene therapy enhances the in vivo sensitivity of Ewing's sarcoma to VP-16.
Cancer gene therapy 2002;9(5):407-13.
2002: Shu-Fang Jia; Laura L Worth; Charles L Densmore; Bo Xu; Zhichao Zhou; Eugenie S Kleinerman
Eradication of osteosarcoma lung metastases following intranasal interleukin-12 gene therapy using a nonviral polyethylenimine vector.
Cancer gene therapy 2002;9(3):260-6.
2002: Shu-Fang Jia; Laura L Worth; Mustofo Turan; Xiao-ping Duan Xp; Eugenie S Kleinerman
Eradication of osteosarcoma lung metastasis using intranasal gemcitabine.
Anti-cancer drugs 2002;13(2):155-61.
2002: Shu-Fang Jia; Leonard A Zwelling; Amanda McWatters; Taeha An; Eugenie S Kleinerman
Interleukin-1 alpha increases the cytotoxic activity of etoposide against human osteosarcoma cells.
Journal of experimental therapeutics & oncology 2002;2(1):27-36.
2001: Charles L Densmore; Eugenie S Kleinerman; Ajay Gautam; Shu-Fang Jia; Bo Xu; Laura L Worth; J Clifford Waldrep; Yuen-Kai Fung; Anne T'Ang; Vernon Knight
Growth suppression of established human osteosarcoma lung metastases in mice by aerosol gene therapy with PEI-p53 complexes.
Cancer gene therapy 2001;8(9):619-27.
2001: Zhichao Zhou; Leonard A Zwelling; Ram Ganapathi; Eugenie S Kleinerman
Enhanced etoposide sensitivity following adenovirus-mediated human topoisomerase IIalpha gene transfer is independent of topoisomerase IIbeta.
British journal of cancer 2001;85(5):747-51.
2001: Laura L Worth; Sima Jeha; Eugenie S Kleinerman
Biologic response modifiers in pediatric cancer.
Hematology/oncology clinics of North America 2001;15(4):723-40, ix.
2001: Elizabeth A Lafleur; Shu-Fang Jia; Laura L Worth; Zhichao Zhou; Laurie B Owen-Schaub; Eugenie S Kleinerman
Interleukin (IL)-12 and IL-12 gene transfer up-regulate Fas expression in human osteosarcoma and breast cancer cells.
Cancer research 2001;61(10):4066-71.
2001: Zhichao Zhou; Shu-Fang Jia; Mien-Chie Hung; Eugenie S Kleinerman
E1A sensitizes HER2/neu-overexpressing Ewing's sarcoma cells to topoisomerase II-targeting anticancer drugs.
Cancer research 2001;61(8):3394-8.
2000: Laura L Worth; Shu-Fang Jia; Zhichao Zhou; L Chen; Eugenie S Kleinerman
Intranasal therapy with an adenoviral vector containing the murine interleukin-12 gene eradicates osteosarcoma lung metastases.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(9):3713-8.
2000: Nadezhda V Koshkina; Eugenie S Kleinerman; C Waidrep; Shu-Fang Jia; Laura L Worth; Brian E Gilbert; Vernon Knight
9-Nitrocamptothecin liposome aerosol treatment of melanoma and osteosarcoma lung metastases in mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(7):2876-80.
2000: Vernon Knight; Eugenie S Kleinerman; J Clifford Waldrep; Beppino C Giovanella; Brian E Gilbert; Nadezhda V Koshkina
9-Nitrocamptothecin liposome aerosol treatment of human cancer subcutaneous xenografts and pulmonary cancer metastases in mice.
Annals of the New York Academy of Sciences 2000;922():151-63.
2000: Vernon Knight; Nadezhda V Koshkina; Clifford Waldrep; Beppino C Giovanella; Eugenie S Kleinerman; B Gilbert
Anti-cancer activity of 9-nitrocamptothecin liposome aerosol in mice.
Transactions of the American Clinical and Climatological Association 2000;111():135-45.
1999: Zhichao Zhou; Leonard A Zwelling; Y Kawakami; Taeha An; K Kobayashi; C Herzog; Eugenie S Kleinerman
Adenovirus-mediated human topoisomerase IIalpha gene transfer increases the sensitivity of etoposide-resistant human breast cancer cells.
Cancer research 1999;59(18):4618-24.
1999: Laura L Worth; Shu-Fang Jia; Taeha An; Eugenie S Kleinerman
ImmTher, a lipophilic disaccharide derivative of muramyl dipeptide, up-regulates specific monocyte cytokine genes and activates monocyte-mediated tumoricidal activity.
Cancer immunology, immunotherapy : CII 1999;48(6):312-20.
1999: Shu-Fang Jia; Taeha An; Laura L Worth; Eugenie S Kleinerman
Interferon-alpha enhances the sensitivity of human osteosarcoma cells to etoposide.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999;19(6):617-24.
1999: Shu-Fang Jia; Laura L Worth; Eugenie S Kleinerman
A nude mouse model of human osteosarcoma lung metastases for evaluating new therapeutic strategies.
Clinical & experimental metastasis 1999;17(6):501-6.
1998: MA Gianan; Eugenie S Kleinerman
Liposomal muramyl tripeptide (CGP 19835A lipid) therapy for resectable melanoma in patients who were at high risk for relapse: an update.
Cancer biotherapy & radiopharmaceuticals 1998;13(5):363-8.
1997: Laura L Worth; Norman Jaffe; Robert S Benjamin; Nicholas E Papadopoulos; Shreyaskumar Patel; A Kevin Raymond; Shu-Fang Jia; C Rodriguez; Jacalyn B Gano; MA Gianan; Eugenie S Kleinerman
Phase II study of recombinant interleukin 1alpha and etoposide in patients with relapsed osteosarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(10):1721-9.
1996: T Asano; Taeha An; J Mayes; Leonard A Zwelling; Eugenie S Kleinerman
Transfection of human topoisomerase II alpha into etoposide-resistant cells: transient increase in sensitivity followed by down-regulation of the endogenous gene.
The Biochemical journal 1996;319 ( Pt 1)():307-13.
1996: T Asano; Taeha An; Shu-Fang Jia; Eugenie S Kleinerman
Altered monocyte chemotactic and activating factor gene expression in human glioblastoma cell lines increased their susceptibility to cytotoxicity.
Journal of leukocyte biology 1996;59(6):916-24.
1996: T Asano; Leonard A Zwelling; Taeha An; A McWatters; Cynthia E Herzog; J Mayes; SM Loughlin; Eugenie S Kleinerman
Effect of transfection of a Drosophila topoisomerase II gene into a human brain tumour cell line intrinsically resistant to etoposide.
British journal of cancer 1996;73(11):1373-80.
1996: James L Murray; Eugenie S Kleinerman; Shu-Fang Jia; Michael G Rosenblum; Omar Eton; Antonio C Buzaid; Sewa S Legha; Merrick I Ross; L Thompson; K Mujoo; P T Rieger; M Saleh; M B Khazaeli; S Vadhan-Raj
Phase Ia/Ib trial of anti-GD2 chimeric monoclonal antibody 14.18 (ch14.18) and recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) in metastatic melanoma.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1996;19(3):206-17.
1996: T Asano; Taeha An; Leonard A Zwelling; H Takano; A T Fojo; Eugenie S Kleinerman
Transfection of a human topoisomerase II alpha gene into etoposide-resistant human breast tumor cells sensitizes the cells to etoposide.
Oncology research 1996;8(3):101-10.
1995: Cynthia E Herzog; Leonard A Zwelling; A McWatters; Eugenie S Kleinerman
Expression of topoisomerase II, bcl-2, and p53 in three human brain tumor cell lines and their possible relationship to intrinsic resistance to etoposide.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(11):1391-7.
1995: Eugenie S Kleinerman
Biologic therapy for osteosarcoma using liposome-encapsulated muramyl tripeptide.
Hematology/oncology clinics of North America 1995;9(4):927-38.
1995: Jacalyn B Gano; Eugenie S Kleinerman
Liposomal MTP-PE: a promising new biologic response modifier.
Oncology nursing forum 1995;22(5):809-16.
1995: Eugenie S Kleinerman; Jacalyn B Gano; D A Johnston; Robert S Benjamin; Norman Jaffe
Efficacy of liposomal muramyl tripeptide (CGP 19835A) in the treatment of relapsed osteosarcoma.
American journal of clinical oncology 1995;18(2):93-9.
1995: Eugenie S Kleinerman; Paul A Meyers; A Kevin Raymond; Jacalyn B Gano; Shu-Fang Jia; Norman Jaffe
Combination therapy with ifosfamide and liposome-encapsulated muramyl tripeptide: tolerability, toxicity, and immune stimulation.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1995;17(3):181-93.
1995: T Asano; Bradley W McIntyre; J L Bednarczyk; J N Wygant; Eugenie S Kleinerman
Liposomal muramyl tripeptide upregulates adhesion molecules on the surface of human monocytes.
Oncology research 1995;7(5):253-7.
1995: Diana Risin; Eugenie S Kleinerman; Y Umezu; R P Pizzini; Charles M Balch; Neal R Pellis
Impairment of lymphocyte locomotion in the tumor microenvironment and the effect of systemic immunotherapy with liposome-encapsulated muramyl-tripeptide-phosphatidylethanolamine.
Cancer immunology, immunotherapy : CII 1995;40(1):57-64.
1995: Jacalyn B Gano; Eugenie S Kleinerman
Administration of liposomal MTP-PE by the local physician: the role of the research nurse.
Cancer practice 1995;3(1):42-6.
1994: Jacalyn B Gano; Eugenie S Kleinerman
Liposomal MTP-PE.
Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses 1994;11(4):161-3.
1994: T Asano; A McWatters; Taeha An; K Matsushima; Eugenie S Kleinerman
Liposomal muramyl tripeptide up-regulates interleukin-1 alpha, interleukin-1 beta, tumor necrosis factor-alpha, interleukin-6 and interleukin-8 gene expression in human monocytes.
The Journal of pharmacology and experimental therapeutics 1994;268(2):1032-9.
1994: T Asano; K Matsushima; Eugenie S Kleinerman
Liposome-encapsulated muramyl tripeptide up-regulates monocyte chemotactic and activating factor gene expression in human monocytes at the transcriptional and post-transcriptional levels.
Cancer immunology, immunotherapy : CII 1994;38(1):16-22.
1993: T Asano; Eugenie S Kleinerman
Liposome-encapsulated MTP-PE: a novel biologic agent for cancer therapy.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1993;14(4):286-92.
1993: T Asano; W Fujimaki; A McWatters; Taeha An; K Matsushima; Eugenie S Kleinerman
Effect of Adriamycin on liposomal muramyl tripeptide's ability to up-regulate monocyte cytokine expression.
Cancer immunology, immunotherapy : CII 1993;37(6):408-11.
1993: M Maeda; T Asano; Eugenie S Kleinerman
Anti-(tumor necrosis factor) alters the response of human monocytes to liposomal muramyl tripeptide.
Cancer immunology, immunotherapy : CII 1993;37(3):203-8.
1993: Steven A Curley; M S Roh; Barry W Feig; C Oyedeji; Eugenie S Kleinerman; Jim Klostergaard
Mechanisms of Kupffer cell cytotoxicity in vitro against the syngeneic murine colon adenocarcinoma line MCA26.
Journal of leukocyte biology 1993;53(6):715-21.
1993: W Fujimaki; J R Griffin; Eugenie S Kleinerman
Effect of ibuprofen on monocyte activation by liposome-encapsulated muramyl tripeptide phosphatidylethanolamine (CGP 19835A): can ibuprofen reduce fever and chills without compromising immune stimulation?
Cancer immunology, immunotherapy : CII 1993;36(1):45-51.
1992: Eugenie S Kleinerman; Shu-Fang Jia; J Griffin; N L Seibel; Robert S Benjamin; Norman Jaffe
Phase II study of liposomal muramyl tripeptide in osteosarcoma: the cytokine cascade and monocyte activation following administration.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1992;10(8):1310-6.
1992: Eugenie S Kleinerman; A Kevin Raymond; Corazon D Bucana; Norman Jaffe; Michael B Harris; I H Krakoff; R Benjamin; Isaiah J Fidler
Unique histological changes in lung metastases of osteosarcoma patients following therapy with liposomal muramyl tripeptide (CGP 19835A lipid).
Cancer immunology, immunotherapy : CII 1992;34(4):211-20.
1992: Jerald J Killion; Eugenie S Kleinerman; M R Wilson; M Tanaka; Isaiah J Fidler
Sequential therapy with chemotherapeutic drugs and liposome-encapsulated muramyl tripeptide: determination of potential interactions between these agents.
Oncology research 1992;4(10):413-8.
1991: S F Jia; Eugenie S Kleinerman
Antitumor activity of TNF-alpha, IL-1, and IFN-gamma against three human osteosarcoma cell lines.
Lymphokine and cytokine research 1991;10(4):281-4.
1991: Eugenie S Kleinerman; J S Snyder; Norman Jaffe
Influence of chemotherapy administration on monocyte activation by liposomal muramyl tripeptide phosphatidylethanolamine in children with osteosarcoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1991;9(2):259-67.
1991: M Maeda; R D Knowles; Eugenie S Kleinerman
Muramyl tripeptide phosphatidylethanolamine encapsulated in liposomes stimulates monocyte production of tumor necrosis factor and interleukin-1 in vitro.
Cancer communications 1991;3(10-11):313-21.
1990: M Wetzler; Moshe Talpaz; Eugenie S Kleinerman; A King; Y O Huh; Jordan U Gutterman; Razelle Kurzrock
A new familial immunodeficiency disorder characterized by severe neutropenia, a defective marrow release mechanism, and hypogammaglobulinemia.
The American journal of medicine 1990;89(5):663-72.
1990: Roberta Anne Gottlieb; Eugenie S Kleinerman; C A O'Brian; S Tsujimoto; G J Cianciolo; W J Lennarz
Inhibition of protein kinase C by a peptide conjugate homologous to a domain of the retroviral protein p15E.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(8):2566-70.
1990: M M Hudson; A B Markowitz; Jordan U Gutterman; R D Knowles; J S Snyder; Eugenie S Kleinerman
Effect of recombinant human interleukin 4 on human monocyte activity.
Cancer research 1990;50(11):3154-8.
1990: M Sarmiento; Eugenie S Kleinerman
Innate resistance to herpes simplex virus infection. Human lymphocyte and monocyte inhibition of viral replication.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(5):1942-53.
1990: Eugenie S Kleinerman; Norman Jaffe
Liposomal MTP-PE for the adjuvant therapy of osteosarcoma.
Progress in clinical and biological research 1990;343():263-79.
1990: Steven A Curley; M S Roh; Eugenie S Kleinerman; Jim Klostergaard
Human recombinant macrophage colony stimulating factor activates murine Kupffer cells to a cytotoxic state.
Lymphokine research 1990;9(3):355-63.
1990: Isaiah J Fidler; A Nii; T Utsugi; D Brown; O Bakouche; Eugenie S Kleinerman
Differential release of TNF-alpha, IL 1, and PGE2 by human blood monocytes subsequent to interaction with different bacterial derived agents.
Lymphokine research 1990;9(4):449-63.
1989: James L Murray; Eugenie S Kleinerman; Joan E. Cunningham; J R Tatom; K Andrejcio; J Lepe-Zuniga; L M Lamki; Michael G Rosenblum; H Frost; Jordan U Gutterman
Phase I trial of liposomal muramyl tripeptide phosphatidylethanolamine in cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1989;7(12):1915-25.
1989: Eugenie S Kleinerman; R D Knowles; M B Blick; L A Zwelling
Lithium chloride stimulates human monocytes to secrete tumor necrosis factor/cachectin.
Journal of leukocyte biology 1989;46(5):484-92.
1989: Eugenie S Kleinerman; James L Murray; J S Snyder; Joan E. Cunningham; Isaiah J Fidler
Activation of tumoricidal properties in monocytes from cancer patients following intravenous administration of liposomes containing muramyl tripeptide phosphatidylethanolamine.
Cancer research 1989;49(16):4665-70.
1989: Roberta Anne Gottlieb; W J Lennarz; R D Knowles; G J Cianciolo; C A Dinarello; L B Lachman; Eugenie S Kleinerman
Synthetic peptide corresponding to a conserved domain of the retroviral protein p15E blocks IL-1-mediated signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(12):4321-8.
1989: Isaiah J Fidler; A Nii; J Y Tsao; S Davis; Eugenie S Kleinerman
Activated human blood monocytes trigger the antitumor activity of blood polymorphonuclear cells.
Lymphokine research 1989;8(4):427-37.
1989: H Shimizu; D Wyatt; R D Knowles; C D Bucana; E J Stanbridge; Eugenie S Kleinerman
Human monocytes selectively bind to cells expressing the tumorigenic phenotype.
Cancer immunology, immunotherapy : CII 1989;28(3):185-92.
1988: M M Hudson; J S Snyder; Norman Jaffe; Eugenie S Kleinerman
In vitro and in vivo effect of adriamycin therapy on monocyte activation by liposome-encapsulated immunomodulators.
Cancer research 1988;48(18):5256-63.
1988: Eugenie S Kleinerman; R D Knowles; L B Lachman; Jordan U Gutterman
Effect of recombinant granulocyte/macrophage colony-stimulating factor on human monocyte activity in vitro and following intravenous administration.
Cancer research 1988;48(9):2604-9.
1988: O Bakouche; L B Lachman; R D Knowles; Eugenie S Kleinerman
Cytotoxic liposomes: membrane interleukin 1 presented in multilamellar vesicles.
Lymphokine research 1988;7(4):445-56.
1987: Eugenie S Kleinerman; L B Lachman; R D Knowles; R Snyderman; G J Cianciolo
A synthetic peptide homologous to the envelope proteins of retroviruses inhibits monocyte-mediated killing by inactivating interleukin 1.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(7):2329-37.
1987: L B Lachman; O Bakouche; Eugenie S Kleinerman
Contradictory action of interleukin-1: cell growth and tumour cell killing.
Annales de l'Institut Pasteur. Immunology 1987;138(3):500-4.
1986: Eugenie S Kleinerman; R Kurzrock; D Wyatt; J R Quesada; J U Gutterman; I J Fidler
Activation or suppression of the tumoricidal properties of monocytes from cancer patients following treatment with human recombinant gamma-interferon.
Cancer research 1986;46(10):5401-5.