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Christoph Kleinschnitz

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Kim A Radermacher; Kirstin Wingler; Sebastian Altenhöfer; J J Rob Hermans; Martin Hrabe de Angelis; Pamela Kleikers; Christoph Kleinschnitz; Friederike Langhauser; Harald H H W Schmidt
Neuroprotection after stroke by targeting NOX4 as a source of oxidative stress.
Jens Minnerup; Christoph Kleinschnitz
No risk, no benefit: still true for antithrombotic stroke treatments?
Christiane Albert-Weißenberger; Anna-Leena Sirén; Christoph Kleinschnitz
Ischemic stroke and traumatic brain injury: the role of the kallikrein-kinin system.

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2013: Kim A Radermacher; Kirstin Wingler; Sebastian Altenhöfer; J J Rob Hermans; Martin Hrabe de Angelis; Pamela Kleikers; Christoph Kleinschnitz; Friederike Langhauser; Harald H H W Schmidt
Neuroprotection after stroke by targeting NOX4 as a source of oxidative stress.
Antioxidants & redox signaling 2013;18(12):1418-27.
2013: Jens Minnerup; Christoph Kleinschnitz
No risk, no benefit: still true for antithrombotic stroke treatments?
Future medicinal chemistry 2013;5(4):377-9.
2013: Christiane Albert-Weißenberger; Anna-Leena Sirén; Christoph Kleinschnitz
Ischemic stroke and traumatic brain injury: the role of the kallikrein-kinin system.
Progress in neurobiology 2013;101-102():65-82.
2013: Joseph Andronic; Stefan Bittner; Nicole Bobak; Thomas Budde; Petra Ehling; Alexander M Herrmann; Christoph Kleinschnitz; Sven G Meuth; Markus Sauer; Heinz Wiendl; Heiko Zimmermann; Vladimir Sukhorukov
Identification of two-pore domain potassium channels as potent modulators of osmotic volume regulation in human T lymphocytes.
Biochimica et biophysica acta 2013;1828(2):699-707.
2013: Christoph Kleinschnitz; Peter Kraft; Friederike Langhauser; Tim Magnus; Christian T Mayer; Sven G Meuth; Bernhard Nieswandt; Mirko Pham; Michael K Schuhmann; Tobias Schwarz; Tim D. Sparwasser; Guido Stoll; Csanad Varallyay; Martin Bendszus; Stefan Bittner; Marc Brede; Angela Dreykluft; Kerstin Göbel; Ina Hagedorn; Xavier Helluy; Yoichiro Iwakura; Peter Jakob; Alma Zernecke; Heinz Wiendl
Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature.
Blood 2013;121(4):679-91.
2013: Christian Geis; Ignaz Gunreben; Christoph Kleinschnitz
Acute tetraparesis secondary to bilateral precentral gyral cerebral ischemia: a case report.
Journal of medical case reports 2013;7(1):61.
2013: Petra Ehling; Christoph Kleinschnitz; Stefan Bittner; Nicole Bobak; Thomas Budde; Tobias Schwarz; Heinz Wiendl; Sven G Meuth
Correction: Two pore domain potassium channels in cerebral ischemia: a focus on K2P9.1 (TASK3, KCNK9).
Experimental & translational stroke medicine 2013;5(1):3.
2013: Stefanie Kristin Golombeck; Nico Melzer; Camelia-Maria Monoranu; Ansgar Schütz; Laszlo Solymosi; Carsten Wessig; Christoph Kleinschnitz
Fatal atypical reversible posterior leukoencephalopathy syndrome: a case report.
Journal of medical case reports 2013;7(1):14.
2012: Friederike Langhauser; Keith R McCrae; Sven G Meuth; Bernhard Nieswandt; Mirko Pham; Joachim Schmitt; Guido Stoll; Peter Kraft; Martin Bendszus; Marc Brede; Christian Geis; Eva Göb; Kerstin Göbel; Xavier Helluy; Peter Jakob; Christoph Kleinschnitz
Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation.
Blood 2012;120(19):4082-92.
2012: Christoph Kleinschnitz; N Plesnila
[Experimental therapy approaches for ischemic stroke].
Der Nervenarzt 2012;83(10):1275-81.
2012: Peter Kraft; Simon F De Meyer; Christoph Kleinschnitz
Next-generation antithrombotics in ischemic stroke: preclinical perspective on 'bleeding-free antithrombosis'.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2012;32(10):1831-40.
2012: Kirstin Wingler; Sebastian A Altenhoefer; Pamela W M Kleikers; Christoph Kleinschnitz; Kim A Radermacher; Harald H H W Schmidt
VAS2870 is a pan-NADPH oxidase inhibitor.
Cellular and molecular life sciences : CMLS 2012;69(18):3159-60.
2012: Nadine Heydenreich; Marion Hofmeister; Christiane Albert-Weissenberger; Marc Brede; Gerhard Dickneite; Eva Göb; Kerstin Göbel; Peter Kraft; Friederike Langhauser; Sven G Meuth; Bernhard Nieswandt; Marc W Nolte; Guido Stoll; Csanad Varallyay; Christoph Kleinschnitz
C1-inhibitor protects from brain ischemia-reperfusion injury by combined antiinflammatory and antithrombotic mechanisms.
Stroke; a journal of cerebral circulation 2012;43(9):2457-67.
2012: Christiane Albert-Weissenberger; Michael Bader; Kerstin Göbel; Sven G Meuth; Anna-Leena Sirén; Christian Stetter; Christoph Kleinschnitz
Blocking of bradykinin receptor B1 protects from focal closed head injury in mice by reducing axonal damage and astroglia activation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2012;32(9):1747-56.
2012: Roger van Kruchten; Edouard M Bevers; Attila Braun; Marion A H Feijge; Christoph Kleinschnitz; Peter Kraft; Marijke J E Kuijpers; Bernhard Nieswandt; Ronmy Rivera-Galdos; Guido Stoll; Johan W M Heemskerk
Antithrombotic potential of blockers of store-operated calcium channels in platelets.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(7):1717-23.
2012: Brad A Sutherland; Jens Minnerup; Francesco Arba; Joyce S Balami; Alastair M Buchan; Christoph Kleinschnitz
Neuroprotection for ischaemic stroke: translation from the bench to the bedside.
International journal of stroke : official journal of the International Stroke Society 2012;7(5):407-18.
2012: Harald H H W Schmidt; Kirstin Wingler; Christoph Kleinschnitz; Greg Dusting
NOX4 is a Janus-faced reactive oxygen species generating NADPH oxidase.
Circulation research 2012;111(1):e15-6; author reply e17-8.
2012: Tim Magnus; Heinz Wiendl; Christoph Kleinschnitz
Immune mechanisms of stroke.
Current opinion in neurology 2012;25(3):334-40.
2012: P Kraft; B Nieswandt; Guido Stoll; Christoph Kleinschnitz
[Acute ischemic stroke. New approaches to antithrombotic treatment].
Der Nervenarzt 2012;83(4):435-49.
2012: Simon F De Meyer; Guido Stoll; Denisa D Wagner; Christoph Kleinschnitz
von Willebrand factor: an emerging target in stroke therapy.
Stroke; a journal of cerebral circulation 2012;43(2):599-606.
2012: Mirko Pham; Guido Stoll; Martin Bendszus; Bernhard Nieswandt; Christoph Kleinschnitz
Blood coagulation factor XII--a neglected player in stroke pathophysiology.
Journal of molecular medicine (Berlin, Germany) 2012;90(2):119-26.
2012: Irina Pleines; Jolanda van Hengel; Stefan Offermanns; Cord Brakebusch; Lidija Chakarova; Shuchi Gupta; Ina Hagedorn; Christoph Kleinschnitz; Georg Krohne; Frauke May; Bernhard Nieswandt
Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis.
Blood 2012;119(4):1054-63.
2012: Furat Raslan; Saker Saker; Thomas Westermaier; Christiane Albert-Weißenberger; Christoph Kleinschnitz; Jin-Yul Lee
A modified double injection model of cisterna magna for the study of delayed cerebral vasospasm following subarachnoid hemorrhage in rats.
Experimental & translational stroke medicine 2012;4(1):23.
2012: Ralf A Linker; Tim Magnus; Sven G Meuth; Christoph Kleinschnitz; Thomas Korn
Report on the 4'th scientific meeting of the "Verein zur Förderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Motzen, Germany, Nov. 2'nd - Nov. 4'th, 2012.
Experimental & translational stroke medicine 2012;4(1):22.
2012: Jens Minnerup; Brad A Sutherland; Alastair M Buchan; Christoph Kleinschnitz
Neuroprotection for stroke: current status and future perspectives.
International journal of molecular sciences 2012;13(9):11753-72.
2012: Johannes Boltze; Christoph Kleinschnitz; Alexander Kranz; Dominik Michalski; Georg Reiser; Klaus G Reymann; Daniel-Christoph Wagner
Neurovascular pathophysiology in cerebral ischemia, dementia and the ageing brain - current trends in basic, translational and clinical research.
Experimental & translational stroke medicine 2012;4():14.
2012: Kim A Radermacher; Kirstin Wingler; Sebastian Altenhöfer; Johannes Jr Hermans; Pamela Kleikers; Christoph Kleinschnitz; Harald Hhw Schmidt
The 1027th target candidate in stroke: Will NADPH oxidase hold up?
Experimental & translational stroke medicine 2012;4(1):11.
2012: Furat Raslan; Christiane Albert-Weißenberger; Ralf-Ingo Ernestus; Christoph Kleinschnitz; Anna-Leena Sirén
Focal brain trauma in the cryogenic lesion model in mice.
Experimental & translational stroke medicine 2012;4():6.
2012: Christoph Kleinschnitz; Thomas Korn; Ralf A Linker; Tim Magnus; Sven G Meuth
Report on the 3'rd scientific meeting of the "Verein zur Förderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Motzen, Germany, Nov. 4'th - Nov. 6'th, 2011.
Experimental & translational stroke medicine 2012;4(1):2.
2012: Christiane Albert-Weißenberger; Christoph Kleinschnitz; Furat Raslan; Csanád Várrallyay; Anna-Leena Sirén
An experimental protocol for mimicking pathomechanisms of traumatic brain injury in mice.
Experimental & translational stroke medicine 2012;4():1.
2012: Stefan Braeuninger; Christoph Kleinschnitz; Bernhard Nieswandt; Guido Stoll
Focal cerebral ischemia.
Methods in molecular biology (Clifton, N.J.) 2012;788():29-42.
2011: Marc Brede; Lutz Hein; Friederike Langhauser; Norbert Roewer; Guido Stoll; Stefan Braeuninger; Christoph Kleinschnitz
α(2)-adrenoceptors do not mediate neuroprotection in acute ischemic stroke in mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2011;31(10):e1-7.
2011: S Bittner; K Göbel; K Höhn; Christoph Kleinschnitz; H Wiendl; Sven G Meuth
[Pregabalin and gabapentin in multiple sclerosis: clinical experiences and therapeutic implications].
Der Nervenarzt 2011;82(10):1273-80.
2011: Bernhard Nieswandt; Christoph Kleinschnitz; Guido Stoll
Ischaemic stroke: a thrombo-inflammatory disease?
The Journal of physiology 2011;589(Pt 17):4115-23.
2011: Jens Minnerup; Christoph Kleinschnitz
Visualization of clot composition in ischemic stroke: do we get what we see?
Stroke; a journal of cerebral circulation 2011;42(5):1193-4.
2011: Christoph Kleinschnitz; Kinga Blecharz; Timo Kahles; Tobias Schwarz; Peter Kraft; Kerstin Göbel; Sven G Meuth; Malgorzata Burek; Thomas Thum; Guido Stoll; Carola Förster
Glucocorticoid insensitivity at the hypoxic blood-brain barrier can be reversed by inhibition of the proteasome.
Stroke; a journal of cerebral circulation 2011;42(4):1081-9.
2011: Kerstin Göbel; Susann Pankratz; Tilman Schneider-Hohendorf; Stefan Bittner; Michael K Schuhmann; Harald F Langer; Guido Stoll; Heinz Wiendl; Christoph Kleinschnitz; Sven G Meuth
Blockade of the kinin receptor B1 protects from autoimmune CNS disease by reducing leukocyte trafficking.
Journal of autoimmunity 2011;36(2):106-14.
2011: Mirko Pham; Xavier Helluy; Christoph Kleinschnitz; Peter Kraft; Andreas J Bartsch; Peter Jakob; Bernhard Nieswandt; Martin Bendszus; Guido Stoll
Sustained reperfusion after blockade of glycoprotein-receptor-Ib in focal cerebral ischemia: an MRI study at 17.6 Tesla.
PloS one 2011;6(4):e18386.
2011: Tim Magnus; Ralf A Linker; Sven G Meuth; Christoph Kleinschnitz; Thomas Korn
Report on the 2nd scientific meeting of the "Verein zur Förderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Motzen, Germany, Oct. 29'th - Oct. 31'st, 2010.
Experimental & translational stroke medicine 2011;3(1):3.
2011: Stefan Bittner; Nicole Bobak; Thomas Budde; Martin Feuchtenberger; Oliver Frey; Kerstin Göbel; Anker J Hansen; Alexander M Herrmann; Raimund W Kinne; Christoph Kleinschnitz; Hans-Peter Tony; Heinz Wiendl; Sven G Meuth
Expression of K2P5.1 potassium channels on CD4+ T lymphocytes correlates with disease activity in rheumatoid arthritis patients.
Arthritis research & therapy 2011;13(1):R21.
2010: Alexander M Herrmann; Kerstin Göbel; Ole J Simon; Nico Melzer; Michael K Schuhmann; Max-Philipp Stenner; Andreas Weishaupt; Christoph Kleinschnitz; Stefan Bittner; Patrick Meuth; Olaf Stuve; Thomas Budde; Bernd C Kieseier; Heinz Wiendl; Sven G Meuth
Glatiramer acetate attenuates pro-inflammatory T cell responses but does not directly protect neurons from inflammatory cell death.
The American journal of pathology 2010;177(6):3051-60.
2010: Guido Stoll; Christoph Kleinschnitz; Bernhard Nieswandt
Combating innate inflammation: a new paradigm for acute treatment of stroke?
Annals of the New York Academy of Sciences 2010;1207():149-54.
2010: Sven G Meuth; Stefan Bittner; Jochen C Ulzheimer; Christoph Kleinschnitz; Bernd C Kieseier; Heinz Wiendl
Therapeutic approaches to multiple sclerosis: an update on failed, interrupted, or inconclusive trials of neuroprotective and alternative treatment strategies.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2010;24(5):317-30.
2010: Simon F De Meyer; Tobias Schwarz; Hans Deckmyn; Cécile V Denis; Bernhard Nieswandt; Guido Stoll; Karen Vanhoorelbeke; Christoph Kleinschnitz
Binding of von Willebrand factor to collagen and glycoprotein Ibalpha, but not to glycoprotein IIb/IIIa, contributes to ischemic stroke in mice--brief report.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(10):1949-51.
2010: Guido Stoll; Christoph Kleinschnitz; Bernhard Nieswandt
The role of glycoprotein Ibalpha and von Willebrand factor interaction in stroke development.
Hämostaseologie 2010;30(3):136-8.
2010: Jochen C Ulzheimer; Sven G Meuth; Stefan Bittner; Christoph Kleinschnitz; Bernd C Kieseier; Heinz Wiendl
Therapeutic approaches to multiple sclerosis: an update on failed, interrupted, or inconclusive trials of immunomodulatory treatment strategies.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2010;24(4):249-74.
2010: Furat Raslan; Tobias Schwarz; Sven G Meuth; Madeleine Austinat; Michael Bader; Thomas Renné; Klaus Roosen; Guido Stoll; Anna-Leena Sirén; Christoph Kleinschnitz
Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010;30(8):1477-86.
2010: Christoph Kleinschnitz; Nicholas Schwab; Peter Kraft; Ina Hagedorn; Angela Dreykluft; Tobias Schwarz; Madeleine Austinat; Bernhard Nieswandt; Heinz Wiendl; Guido Stoll
Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation.
Blood 2010;115(18):3835-42.
2010: Ina Hagedorn; Stefan Schmidbauer; Irina Pleines; Christoph Kleinschnitz; Ulrich Kronthaler; Guido Stoll; Gerhard Dickneite; Bernhard Nieswandt
Factor XIIa inhibitor recombinant human albumin Infestin-4 abolishes occlusive arterial thrombus formation without affecting bleeding.
Circulation 2010;121(13):1510-7.
2010: Nurcan Üçeyler; Kerstin Göbel; Sven G Meuth; Sonja Ortler; Guido Stoll; Claudia Sommer; Heinz Wiendl; Christoph Kleinschnitz
Deficiency of the negative immune regulator B7-H1 enhances inflammation and neuropathic pain after chronic constriction injury of mouse sciatic nerve.
Experimental neurology 2010;222(1):153-60.
2010: M Pham; Christoph Kleinschnitz; X Helluy; Andreas Joachim Bartsch; M Austinat; V C Behr; Thomas Renné; Bernhard Nieswandt; Guido Stoll; Martin Bendszus
Enhanced cortical reperfusion protects coagulation factor XII-deficient mice from ischemic stroke as revealed by high-field MRI.
NeuroImage 2010;49(4):2907-14.
2010: Michael K Schuhmann; David Stegner; Alejandro Berna-Erro; Stefan Bittner; Attila Braun; Christoph Kleinschnitz; Guido Stoll; Heinz Wiendl; Sven G Meuth; Bernhard Nieswandt
Stromal interaction molecules 1 and 2 are key regulators of autoreactive T cell activation in murine autoimmune central nervous system inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(3):1536-42.
2010: Peter Kraft; Peter Michael Benz; Madeleine Austinat; Marc Brede; Kai Schuh; Ulrich Walter; Guido Stoll; Christoph Kleinschnitz
Deficiency of vasodilator-stimulated phosphoprotein (VASP) increases blood-brain-barrier damage and edema formation after ischemic stroke in mice.
PloS one 2010;5(12):e15106.
2010: Christoph Kleinschnitz; Henrike Grund; Kirstin Wingler; Melanie E Armitage; Emma Jones; Manish Mittal; David Barit; Tobias Schwarz; Christian Geis; Peter Kraft; Konstanze Barthel; Michael K Schuhmann; Alexander M Herrmann; Sven G Meuth; Guido Stoll; Sabine Meurer; Anja Schrewe; Lore Becker; Valérie Gailus-Durner; Helmut Fuchs; Thomas Klopstock; Martin Hrabé De Angelis; Karin Jandeleit-Dahm; Ajay M Shah; Norbert Weissmann; Harald Schmidt
Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration.
PLoS biology 2010;8(9):.
2010: Peter Kraft; Tobias Schwarz; Joost C M Meijers; Guido Stoll; Christoph Kleinschnitz
Thrombin-activatable fibrinolysis inhibitor (TAFI) deficient mice are susceptible to intracerebral thrombosis and ischemic stroke.
PloS one 2010;5(7):e11658.
2010: Petra Ehling; Stefan Bittner; Nicole Bobak; Tobias Schwarz; Heinz Wiendl; Thomas Budde; Christoph Kleinschnitz; Sven G Meuth
Two pore domain potassium channels in cerebral ischemia: a focus on K2P9.1 (TASK3, KCNK9).
Experimental & translational stroke medicine 2010;2(1):14.
2010: Peter Kraft; Tobias Schwarz; Lionel Pochet; Guido Stoll; Christoph Kleinschnitz
COU254, a specific 3-carboxamide-coumarin inhibitor of coagulation factor XII, does not protect mice from acute ischemic stroke.
Experimental & translational stroke medicine 2010;2(1):5.
2010: Mirko Pham; Xavier Helluy; Stefan Braeuninger; Peter Jakob; Guido Stoll; Christoph Kleinschnitz; Martin Bendszus
Outcome of experimental stroke in C57Bl/6 and Sv/129 mice assessed by multimodal ultra-high field MRI.
Experimental & translational stroke medicine 2010;2():6.
2010: Stefan Braeuninger; Christoph Kleinschnitz; Guido Stoll
Interleukin-18 does not influence infarct volume or functional outcome in the early stage after transient focal brain ischemia in mice.
Experimental & translational stroke medicine 2010;2():1.
2010: Margitta Elvers; David Stegner; Ina Hagedorn; Christoph Kleinschnitz; Attila Braun; Marijke E J Kuijpers; Michael Boesl; Qin Chen; Johan W M Heemskerk; Guido Stoll; Michael A Frohman; Bernhard Nieswandt
Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1.
Science signaling 2010;3(103):ra1.
2009: N Hansen; M Beck; S Leykamm; Christoph Kleinschnitz
[Arm and blood glucose out of control].
MMW Fortschritte der Medizin 2009;151(48):41-2.
2009: Christoph Kleinschnitz; Simon F De Meyer; Tobias Schwarz; Madeleine Austinat; Karen Vanhoorelbeke; Bernhard Nieswandt; Hans Deckmyn; Guido Stoll
Deficiency of von Willebrand factor protects mice from ischemic stroke.
Blood 2009;113(15):3600-3.
2009: Attila Braun; David Varga-Szabo; Christoph Kleinschnitz; Irina Pleines; Markus Bender; Madeleine Austinat; Michael Bösl; Guido Stoll; Bernhard Nieswandt
Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation.
Blood 2009;113(9):2056-63.
2009: Guido Stoll; Christoph Kleinschnitz; Sven G Meuth; Stefan Braeuninger; Chi Wang Ip; Carsten Wessig; Ingo Nölte; Martin Bendszus
Transient widespread blood-brain barrier alterations after cerebral photothrombosis as revealed by gadofluorine M-enhanced magnetic resonance imaging.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009;29(2):331-41.
2009: Stefan Braeuninger; Christoph Kleinschnitz
Rodent models of focal cerebral ischemia: procedural pitfalls and translational problems.
Experimental & translational stroke medicine 2009;1():8.
2009: Wolf-Rüdiger Schäbitz; Christoph Kleinschnitz
Time to overcome the translational roadblock: Introducing a new open access stroke journal.
Experimental & translational stroke medicine 2009;1():1.
2009: Alejandro Berna-Erro; Attila Braun; Robert Kraft; Christoph Kleinschnitz; Michael K Schuhmann; David Stegner; Thomas Wultsch; Jens Eilers; Sven G Meuth; Guido Stoll; Bernhard Nieswandt
STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death.
Science signaling 2009;2(93):ra67.
2009: Madeleine Austinat; Stefan Braeuninger; João B Pesquero; Marc Brede; Michael Bader; Guido Stoll; Thomas Renné; Christoph Kleinschnitz
Blockade of bradykinin receptor B1 but not bradykinin receptor B2 provides protection from cerebral infarction and brain edema.
Stroke; a journal of cerebral circulation 2009;40(1):285-93.
2008: Sven G Meuth; Christoph Kleinschnitz; Heinz Wiendl
Recent clinical trials and future therapies.
Journal of neurology 2008;255 Suppl 6():93-6.
2008: Guido Stoll; Christoph Kleinschnitz; Bernhard Nieswandt
Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment.
Blood 2008;112(9):3555-62.
2008: Christoph Kleinschnitz; Sven G Meuth; Heinz Wiendl
The trials and errors in MS therapy.
International MS journal / MS Forum 2008;15(3):79-90.
2008: Chi Wang Ip; Bianca Kohl; Christoph Kleinschnitz; Bernhard Reuss; Klaus-Armin Nave; Antje Kroner; Rudolf Martini
Origin of CD11b+ macrophage-like cells in the CNS of PLP-overexpressing mice: low influx of haematogenous macrophages and unchanged blood-brain-barrier in the optic nerve.
Molecular and cellular neurosciences 2008;38(4):489-94.
2008: David Varga-Szabo; Attila Braun; Christoph Kleinschnitz; Markus Bender; Irina Pleines; Mirko Pham; Thomas Renné; Guido Stoll; Bernhard Nieswandt
The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction.
The Journal of experimental medicine 2008;205(7):1583-91.
2008: Christoph Kleinschnitz; Madeleine Austinat; Michael Bader; Thomas Renné; Guido Stoll
Deficiency of bradykinin receptor B2 is not detrimental in experimental stroke.
Hypertension 2008;51(5):e41; author reply e42-3.
2008: Christoph Kleinschnitz; Stefan Braeuninger; Mirko Pham; Madeleine Austinat; Ingo Nölte; Thomas Renné; Bernhard Nieswandt; Martin Bendszus; Guido Stoll
Blocking of platelets or intrinsic coagulation pathway-driven thrombosis does not prevent cerebral infarctions induced by photothrombosis.
Stroke; a journal of cerebral circulation 2008;39(4):1262-8.
2008: Stefan Fischer; Christoph Kleinschnitz; Marcus Müller; Igor Kobsar; Chi Wang Ip; Barrett Rollins; Rudolf Martini
Monocyte chemoattractant protein-1 is a pathogenic component in a model for a hereditary peripheral neuropathy.
Molecular and cellular neurosciences 2008;37(2):359-66.
2007: Christoph Kleinschnitz; Sven G Meuth; Olaf Stüve; Bernd C Kieseier; Heinz Wiendl
Multiple sclerosis therapy: an update on recently finished trials.
Journal of neurology 2007;254(11):1473-90.
2007: Christoph Kleinschnitz; Sven G Meuth; Bernd C Kieseier; Heinz Wiendl
[Update on pathophysiologic and immunotherapeutic approaches for the treatment of multiple sclerosis].
Der Nervenarzt 2007;78(8):883-911.
2007: Christoph Kleinschnitz; Miroslava Pozgajova; Mirko Pham; Martin Bendszus; Bernhard Nieswandt; Guido Stoll
Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding.
Circulation 2007;115(17):2323-30.
2007: Martin Bendszus; Christoph Kleinschnitz; Guido Stoll
Iron-enhanced MRI in ischemic stroke: intravascular trapping versus cellular inflammation.
Stroke; a journal of cerebral circulation 2007;38(5):e12; author reply e13.
2007: Christoph Kleinschnitz; Sven G Meuth; Bernd C Kieseier; Heinz Wiendl
Immunotherapeutic approaches in MS: update on pathophysiology and emerging agents or strategies 2006.
Endocrine, metabolic & immune disorders drug targets 2007;7(1):35-63.
2007: Ines Siglienti; Andrew Chan; Christoph Kleinschnitz; Sebastian Jander; Klaus V Toyka; Ralf Gold; Guido Stoll
Downregulation of transforming growth factor-beta2 facilitates inflammation in the central nervous system by reciprocal astrocyte/microglia interactions.
Journal of neuropathology and experimental neurology 2007;66(1):47-56.
2006: Sven G Meuth; Christoph Kleinschnitz; M Frank; Carsten Wessig; Martin Bendszus; W Kress; H Wiendl
Why a positive genetic test for myotonic dystrophy type I does not always imply the right diagnosis.
Journal of neurology, neurosurgery, and psychiatry 2006;77(12):1381-2.
2006: Christoph Kleinschnitz; Harald H Hofstetter; Sven G Meuth; Stefan Braeuninger; Claudia Sommer; Guido Stoll
T cell infiltration after chronic constriction injury of mouse sciatic nerve is associated with interleukin-17 expression.
Experimental neurology 2006;200(2):480-5.
2006: Sven G Meuth; M Isabel Aller; Thomas Munsch; Thekla Schuhmacher; Thomas Seidenbecher; Patrick Meuth; Christoph Kleinschnitz; Hans-Christian Pape; Heinz Wiendl; william wisden; Thomas Budde
The contribution of TWIK-related acid-sensitive K+-containing channels to the function of dorsal lateral geniculate thalamocortical relay neurons.
Molecular pharmacology 2006;69(4):1468-76.
2006: Ines Siglienti; Martin Bendszus; Christoph Kleinschnitz; Guido Stoll
Cytokine profile of iron-laden macrophages: implications for cellular magnetic resonance imaging.
Journal of neuroimmunology 2006;173(1-2):166-73.
2006: Christoph Kleinschnitz; Guido Stoll; Martin Bendszus; Kai Schuh; Hans-Ulrich Pauer; Peter Burfeind; Christoph Renné; David Gailani; Bernhard Nieswandt; Thomas Renné
Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis.
The Journal of experimental medicine 2006;203(3):513-8.
2006: María Rodríguez-Palmero; Angels Franch; Margarida Castell; Carme Pelegrí; Francisco J Pérez-Cano; Christoph Kleinschnitz; Guido Stoll; Thomas Hünig; Cristina Castellote
Effective treatment of adjuvant arthritis with a stimulatory CD28-specific monoclonal antibody.
The Journal of rheumatology 2006;33(1):110-8.
2005: Christoph Kleinschnitz; Ansgar Schütz; Ingo Nölte; Tanja Horn; Marco Frank; Laszlo Solymosi; Guido Stoll; Martin Bendszus
In vivo detection of developing vessel occlusion in photothrombotic ischemic brain lesions in the rat by iron particle enhanced MRI.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(11):1548-55.
2005: Christoph Kleinschnitz; Jörg Brinkhoff; Claudia Sommer; Guido Stoll
Contralateral cytokine gene induction after peripheral nerve lesions: dependence on the mode of injury and NMDA receptor signaling.
Brain research. Molecular brain research 2005;136(1-2):23-8.
2005: Martin Bendszus; Carsten Wessig; Ansgar Schütz; Tanja Horn; Christoph Kleinschnitz; Claudia Sommer; Bernd Misselwitz; Guido Stoll
Assessment of nerve degeneration by gadofluorine M-enhanced magnetic resonance imaging.
Annals of neurology 2005;57(3):388-95.
2004: Christoph Kleinschnitz; Michael Schroeter; Sebastian Jander; Guido Stoll
Induction of granulocyte colony-stimulating factor mRNA by focal cerebral ischemia and cortical spreading depression.
Brain research. Molecular brain research 2004;131(1-2):73-8.
2004: Annette George; Christoph Kleinschnitz; Marek Zelenka; Jörg Brinkhoff; Guido Stoll; Claudia Sommer
Wallerian degeneration after crush or chronic constriction injury of rodent sciatic nerve is associated with a depletion of endoneurial interleukin-10 protein.
Experimental neurology 2004;188(1):187-91.
2004: Christoph Kleinschnitz; Jörg Brinkhoff; M Zelenka; Claudia Sommer; Guido Stoll
The extent of cytokine induction in peripheral nerve lesions depends on the mode of injury and NMDA receptor signaling.
Journal of neuroimmunology 2004;149(1-2):77-83.
2004: Guido Stoll; Michael Schroeter; Sebastian Jander; Heike Siebert; Anja Wollrath; Christoph Kleinschnitz; Wolfgang Brück
Lesion-associated expression of transforming growth factor-beta-2 in the rat nervous system: evidence for down-regulating the phagocytic activity of microglia and macrophages.
Brain pathology (Zurich, Switzerland) 2004;14(1):51-8.
2003: Christoph Kleinschnitz; Martin Bendszus; Marco Frank; Laszlo Solymosi; Klaus V Toyka; Guido Stoll
In vivo monitoring of macrophage infiltration in experimental ischemic brain lesions by magnetic resonance imaging.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(11):1356-61.
2002: Pavel I Nedvetsky; Christoph Kleinschnitz; Harald Schmidt
Regional distribution of protein and activity of the nitric oxide receptor, soluble guanylyl cyclase, in rat brain suggests multiple mechanisms of regulation.
Brain research 2002;950(1-2):148-54.
2002: Ulrike Zabel; Christoph Kleinschnitz; Phil Oh; Pavel I Nedvetsky; Albert Smolenski; Helmut Müller; Petra Kronich; Peter Kugler; Ulrich Walter; Jan Schnitzer; Harald Schmidt
Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxide.
Nature cell biology 2002;4(4):307-11.